HAdb 2.0 is available now!

DENND3

DENN domain containing 3
General Information
Name DENN domain containing 3
Alias
  • DENN domain-containing protein 3
  • DENN/MADD domain containing 3
Gene_family WD repeat domain containing|DENN domain containing
organism Homo sapiens
entrez_id 22898
location 8q24.3
transcript_count 31
exon_count 31
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular protein catabolic process; endosome to lysosome transport; and regulation of Rab protein signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...]
    nextProt Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
DENND3 BioGRID DVL2 GeneID BioGRID Affinity Capture-MS
DENND3 BioGRID H4C1 GeneID BioGRID Proximity Label-MS
DENND3 BioGRID H3-4 GeneID BioGRID Proximity Label-MS
DENND3 BioGRID CBR1 GeneID BioGRID Affinity Capture-MS
StringDB
A B experiments database textmining combined score hadb nhadb
DENND3 RAB27A 0 0 108 265 1 1
DENND3 PCDH7 0 0 157 244 1 1
DENND3 LIMK2 0 0 151 181 1 1
DENND3 PLCH2 0 0 246 251 1 1
DENND3 GALNT16 0 0 270 320 1 1
DENND3 ARHGEF16 0 0 233 232 1 1
DENND3 RABL2A 0 0 0 176 1 1
DENND3 CENPE 0 0 97 153 1 1
DENND3 MGST3 0 0 0 231 1 1
DENND3 NRG3 0 0 142 161 1 1
DENND3 FUT2 0 0 142 232 1 1
DENND3 ZNF132 0 0 138 152 1 1
DENND3 DENND1A 0 0 0 200 1 1
DENND3 OR5J2 0 0 455 573 1 1
DENND3 AIF1 0 0 0 171 1 2
DENND3 MSMO1 0 0 139 192 1 1
DENND3 OLFM1 0 0 181 181 1 1
DENND3 CUL9 0 0 219 219 1 1
DENND3 GNA14 0 0 193 344 1 1
DENND3 FAT3 0 0 152 153 1 1
DENND3 TSPYL2 0 0 209 258 1 1
DENND3 PSD4 0 0 282 311 1 1
DENND3 SYT6 0 0 0 188 1 1
DENND3 BACE2 0 0 52 168 1 1
DENND3 NCLN 0 0 557 756 1 1
DENND3 TFEB 0 0 103 150 1 2
DENND3 SBF1 0 0 206 373 1 1
DENND3 GPR153 0 0 175 175 1 1
DENND3 MYO1G 0 0 71 168 1 1
DENND3 PTPRC 0 0 0 218 1 1
DENND3 RAB35 0 0 174 251 1 1
DENND3 RAB24 0 0 264 274 1 2
DENND3 DENND4B 0 0 372 333 1 1
DENND3 AKTIP 0 0 195 276 1 1
DENND3 RAB9B 0 0 96 199 1 1
DENND3 RAB6C 0 0 0 151 1 1
DENND3 RIC1 0 0 108 263 1 1
DENND3 PHYHIPL 0 0 155 156 1 1
DENND3 TBC1D2 0 0 165 212 1 1
DENND3 TBC1D22A 0 0 307 322 1 1
DENND3 ZBTB25 0 0 108 153 1 1
DENND3 MTERF1 0 0 205 219 1 1
DENND3 PRAF2 0 0 289 398 1 1
DENND3 MARCH2 0 0 95 159 1 1
DENND3 TMUB2 0 0 466 480 1 1
DENND3 CKAP2L 0 0 285 563 1 1
DENND3 PPP6R2 0 0 103 171 1 1
DENND3 GNB5 0 0 160 182 1 1
DENND3 ENPP2 0 0 103 159 1 1
DENND3 ARSG 0 0 108 169 1 1
DENND3 PPAPDC1B 0 0 269 314 1 1
DENND3 MADD 0 0 506 474 1 1
DENND3 INPP1 0 0 243 287 1 1
DENND3 ABT1 0 0 270 337 1 1
DENND3 PRM3 0 0 293 293 1 1
DENND3 RNF19A 0 0 212 428 1 1
DENND3 CLTC 0 0 113 155 1 1
DENND3 TBC1D5 0 0 136 158 1 2
DENND3 TBC1D9B 0 0 122 153 1 1
DENND3 NAP1L5 0 0 211 271 1 1
DENND3 CLDN11 0 0 112 175 1 1
DENND3 VEZF1 0 0 0 432 1 1
DENND3 RFPL3 0 0 310 309 1 1
DENND3 HSDL2 0 0 261 261 1 1
DENND3 SH3RF1 0 0 193 223 1 1
DENND3 RAB6A 0 0 72 179 1 1
DENND3 BCL11A 0 0 0 220 1 1
DENND3 OR1N2 0 0 526 526 1 1
DENND3 RAB36 0 0 0 151 1 1
DENND3 TRIM16L 0 0 381 381 1 1
DENND3 GOLGA3 0 0 73 212 1 1
DENND3 C9orf72 0 0 162 161 1 2
DENND3 GCDH 0 0 218 218 1 1
DENND3 SCUBE3 0 0 90 451 1 1
DENND3 RXFP2 0 0 167 181 1 1
DENND3 ACOT11 0 0 243 319 1 1
DENND3 KALRN 0 0 143 154 1 1
DENND3 CAMSAP2 0 0 279 453 1 1
DENND3 RAB3B 0 0 234 281 1 1
DENND3 DENND1C 0 0 304 403 1 1
DENND3 YTHDF2 0 0 50 236 1 1
DENND3 ZNF25 0 0 129 172 1 1
DENND3 ENSG00000267179 0 0 391 402 1 1
DENND3 CAMKMT 0 0 139 434 1 1
DENND3 FRY 0 0 0 151 1 1
DENND3 ZSCAN1 0 0 146 160 1 1
DENND3 ALKBH3 0 0 66 308 1 1
DENND3 AQP7 0 0 113 174 1 1
DENND3 EXT1 0 0 134 199 1 1
DENND3 RAB8A 0 0 181 222 1 2
DENND3 RASGRP3 0 0 55 283 1 1
DENND3 RAB9A 0 0 124 184 1 2
DENND3 PPP1R12C 0 0 47 242 1 1
DENND3 EBPL 0 0 324 395 1 1
DENND3 RASGRP1 0 0 0 183 1 1
DENND3 RNF40 0 0 182 200 1 1
DENND3 ANKFY1 0 0 0 155 1 1
DENND3 AADAT 0 0 204 247 1 1
DENND3 TOR1A 0 0 0 191 1 1
DENND3 SFXN1 0 0 243 242 1 1
DENND3 HPDL 0 0 0 202 1 1
DENND3 SCUBE2 0 0 0 187 1 1
DENND3 DENND4C 0 0 451 311 1 1
DENND3 ZBTB26 0 0 123 172 1 1
DENND3 KLHL8 0 0 370 381 1 1
DENND3 LCP2 0 0 0 186 1 1
DENND3 PLP1 0 0 0 175 1 1
DENND3 RAB10 0 0 218 364 1 1
DENND3 PDE8B 0 0 208 383 1 1
DENND3 DENND2D 0 0 113 254 1 1
DENND3 RAB12 0 900 652 969 1 2
DENND3 SCAF11 0 0 210 298 1 1
DENND3 SLC45A4 0 0 335 346 1 1
DENND3 MT1E 0 0 146 162 1 1
DENND3 MFAP1 0 0 108 152 1 1
DENND3 RAB5A 0 0 170 182 1 2
DENND3 CHM 0 900 0 900 1 2
DENND3 ADAP2 0 0 93 158 1 1
DENND3 RAB6B 0 0 0 151 1 1
DENND3 SLC1A7 0 0 164 163 1 1
DENND3 MAP1LC3A 180 0 0 179 1 2
DENND3 DCAF16 0 0 323 323 1 1
DENND3 RAB17 0 0 135 266 1 1
DENND3 MVB12B 0 0 294 342 1 1
DENND3 ZCCHC12 0 0 249 283 1 1
DENND3 SCUBE1 0 0 0 187 1 1
DENND3 TLL1 0 0 181 192 1 1
DENND3 RAB33B 0 0 137 159 1 2
DENND3 LMOD1 0 0 215 637 1 1
DENND3 TBC1D25 0 0 194 199 1 1
DENND3 FANCG 0 0 112 178 1 1
DENND3 RAB39B 0 0 265 310 1 1
DENND3 YTHDF1 0 0 54 239 1 1
DENND3 RAB30 0 0 85 177 1 1
DENND3 MON1A 0 0 218 341 1 1
DENND3 MCF2L 0 0 213 223 1 1
DENND3 RAB11B 0 0 0 176 1 1
DENND3 RASL10B 0 0 107 153 1 1
DENND3 FHAD1 0 0 362 535 1 1
DENND3 RAB3D 0 0 201 210 1 1
DENND3 RHOBTB3 0 0 72 181 1 1
DENND3 DNAJB9 0 0 129 192 1 2
DENND3 SPINT1 0 0 164 163 1 1
DENND3 RUFY2 0 0 0 158 1 1
DENND3 NCAPD2 0 0 0 167 1 1
DENND3 NELL1 0 0 180 231 1 1
DENND3 GDI1 0 900 0 900 1 1
DENND3 COMTD1 0 0 134 173 1 1
DENND3 NRSN1 0 0 292 304 1 1
DENND3 HEPHL1 0 0 310 468 1 1
DENND3 RAB2B 0 0 81 161 1 1
DENND3 PIK3CD 0 0 95 165 1 1
DENND3 ZNF385D 0 0 0 207 1 1
DENND3 C15orf39 0 0 421 442 1 1
DENND3 WDR41 0 0 391 447 1 1
DENND3 DENND5B 0 0 322 657 1 1
DENND3 RET 0 0 66 209 1 1
DENND3 ZNF359 0 0 141 182 1 1
DENND3 RAB41 0 0 0 151 1 1
DENND3 GFRA1 0 0 123 156 1 1
DENND3 RASGEF1C 0 0 376 418 1 1
DENND3 ST5 0 0 73 566 1 1
DENND3 THSD7B 0 0 270 474 1 1
DENND3 PLP2 0 0 49 196 1 1
DENND3 CSF3R 0 0 0 151 1 1
DENND3 SLC36A4 0 0 391 404 1 1
DENND3 RAB27B 0 0 155 348 1 1
DENND3 CHD2 0 0 274 285 1 1
DENND3 NUP98 0 0 258 333 1 1
DENND3 QRICH2 0 0 167 167 1 1
DENND3 KIF3A 0 0 112 175 1 1
DENND3 SMCR8 0 0 375 408 1 1
DENND3 UGGT2 0 0 263 427 1 1
DENND3 IQSEC1 0 0 202 219 1 1
DENND3 NECAP1 0 0 315 320 1 1
DENND3 KIAA0368 0 0 229 347 1 1
DENND3 ENSG00000279765 0 0 273 284 1 1
DENND3 DCAF17 0 0 120 424 1 1
DENND3 MYO1F 0 0 0 182 1 1
DENND3 WDFY4 0 0 0 224 1 1
DENND3 TXNL4B 0 0 211 278 1 1
DENND3 AGL 0 0 161 176 1 1
DENND3 ALKBH5 0 0 46 178 1 1
DENND3 PTBP3 0 0 193 193 1 1
DENND3 ZSWIM3 0 0 153 160 1 1
DENND3 DENND2A 0 0 155 379 1 1
DENND3 TBC1D14 0 0 194 195 1 2
DENND3 ULK1 0 900 164 918 1 2
DENND3 RAB7A 0 0 146 175 1 2
DENND3 ATN1 0 0 180 186 1 1
DENND3 NR0B1 0 0 0 219 1 1
DENND3 YTHDF3 0 0 0 157 1 1
DENND3 TFRC 0 0 166 165 1 1
DENND3 RFX3 0 0 194 318 1 1
DENND3 PRPF38B 0 0 125 153 1 1
DENND3 WDFY3 0 0 0 166 1 2
DENND3 CAMSAP1 0 0 0 155 1 1
DENND3 TCEANC2 0 0 400 486 1 1
DENND3 INTS9 0 0 283 398 1 1
DENND3 GPRASP2 0 0 246 309 1 1
DENND3 RAB3GAP1 0 0 181 242 1 1
DENND3 CHIA 0 0 210 239 1 1
DENND3 SYT10 0 0 155 384 1 1
DENND3 HSPA13 0 0 202 270 1 1
DENND3 RABL2B 0 0 0 176 1 1
DENND3 TAF7L 0 0 228 244 1 1
DENND3 DOCK5 0 0 183 201 1 1
DENND3 TMEM189-UBE2V1 0 0 180 179 1 1
DENND3 RBM25 0 0 73 156 1 1
DENND3 RAB34 0 0 66 174 1 1
DENND3 PHOX2B 0 0 112 174 1 1
DENND3 TBATA 0 0 565 698 1 1
DENND3 ZNF507 0 0 120 170 1 1
DENND3 INADL 0 0 134 205 1 1
DENND3 MOB3A 0 0 327 343 1 1
DENND3 HPD 0 0 82 193 1 1
DENND3 L3MBTL2 0 0 210 310 1 1
DENND3 DENND4A 0 0 283 298 1 1
DENND3 MICAL3 0 0 233 340 1 1
DENND3 REXO4 0 0 290 380 1 1
DENND3 ZNF512 0 0 108 163 1 1
DENND3 RAB44 0 0 131 215 1 1
DENND3 SARDH 0 0 204 205 1 1
DENND3 LRRC38 0 0 329 485 1 1
DENND3 DENND1B 0 0 73 211 1 1
DENND3 NCF1 0 0 0 222 1 1
DENND3 SMIM8 0 0 226 225 1 1
DENND3 RAB25 0 0 49 183 1 2
DENND3 DENND5A 0 0 285 653 1 1
DENND3 ZFPM2 0 0 132 241 1 1
DENND3 DENND2C 0 0 140 343 1 1
DENND3 ENSG00000167377 0 0 141 182 1 1
DENND3 ROBO2 0 0 107 195 1 1
DENND3 DNAJB11 0 0 155 155 1 1
DENND3 RBM11 0 0 273 338 1 1
DENND3 CCZ1 0 0 260 340 1 1
DENND3 CHML 0 900 0 900 1 1
DENND3 INPP5J 0 0 241 307 1 1
DENND3 RAB11A 0 0 96 223 1 2
DENND3 METTL14 0 0 46 155 1 1
DENND3 RAB28 0 0 213 450 1 1
DENND3 RAB7B 0 0 136 155 1 1
DENND3 RASGRF2 0 0 193 193 1 1
DENND3 HCRTR2 0 0 0 183 1 1
DENND3 SBF2 0 0 233 344 1 1
DENND3 ALKBH8 0 0 74 326 1 1
DENND3 GNAL 0 0 113 168 1 1
DENND3 LYPLAL1 0 0 187 242 1 1
DENND3 AP2M1 0 0 0 171 1 1
DENND3 VMP1 0 0 0 173 1 2
DENND3 GMFG 0 0 91 151 1 1
DENND3 AVL9 0 0 125 221 1 1
DENND3 TEX30 0 0 211 211 1 1
DENND3 SWAP70 0 0 170 221 1 1
DENND3 MZF1 0 0 127 195 1 1
DENND3 GDI2 0 900 0 900 1 1
DENND3 ISG20L2 0 0 135 243 1 1
DENND3 P4HA1 0 0 241 247 1 1
DENND3 UMODL1 0 0 263 483 1 1
DENND3 CCZ1B 0 0 259 339 1 1
DENND3 ZMYM1 0 0 140 161 1 1
DENND3 UBA7 0 0 0 171 1 1
DENND3 ILF2 0 0 0 179 1 1
DENND3 GPR33 0 0 124 157 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity enables IDA
GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity enables TAS
GO:0008333 Biological Process endosome to lysosome transport involved_in ISS
GO:0030163 Biological Process protein catabolic process involved_in ISS
GO:0032483 Biological Process regulation of Rab protein signal transduction involved_in IBA
GO:0031410 Cellular Component cytoplasmic vesicle is_active_in IBA
GO:0005829 Cellular Component cytosol located_in TAS
Pathways
Name DB ID
Membrane Trafficking Reactome R-HSA-199991
Vesicle-mediated transport Reactome R-HSA-5653656
RAB GEFs exchange GTP for GDP on RABs Reactome R-HSA-8876198
Rab regulation of trafficking Reactome R-HSA-9007101
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_148197 3 miscRNA transcript variant 4 NC_000008 Reference
XR_007060719 1 miscRNA transcript variant X17 NC_000008 Reference
XR_007060720 1 miscRNA transcript variant X20 NC_000008 Reference
XR_928312 4 miscRNA transcript variant X24 NC_000008 Reference
XR_007060722 1 miscRNA transcript variant X26 NC_000008 Reference
XR_007060721 1 miscRNA transcript variant X25 NC_000008 Reference
NM_001362798 2 mRNA transcript variant 5 NC_000008 Reference
XM_011516933 3 mRNA transcript variant X1 NC_000008 Reference
XM_011516934 4 mRNA transcript variant X6 NC_000008 Reference
NM_001352890 3 mRNA transcript variant 1 NC_000008 Reference
XM_047421591 1 mRNA transcript variant X3 NC_000008 Reference
XM_047421595 1 mRNA transcript variant X10 NC_000008 Reference
XM_005250841 5 mRNA transcript variant X4 NC_000008 Reference
XM_047421592 1 mRNA transcript variant X7 NC_000008 Reference
XM_047421598 1 mRNA transcript variant X13 NC_000008 Reference
XM_047421593 1 mRNA transcript variant X8 NC_000008 Reference
XM_047421597 1 mRNA transcript variant X12 NC_000008 Reference
NM_014957 5 mRNA transcript variant 2 NC_000008 Reference
XM_005250840 6 mRNA transcript variant X2 NC_000008 Reference
XM_005250842 5 mRNA transcript variant X5 NC_000008 Reference
XM_047421594 1 mRNA transcript variant X9 NC_000008 Reference
XM_047421596 1 mRNA transcript variant X11 NC_000008 Reference
XM_047421599 1 mRNA transcript variant X14 NC_000008 Reference
XM_011516937 3 mRNA transcript variant X16 NC_000008 Reference
NM_001352891 3 mRNA transcript variant 3 NC_000008 Reference
XM_017013242 2 mRNA transcript variant X15 NC_000008 Reference
XM_047421600 1 mRNA transcript variant X19 NC_000008 Reference
XM_011516938 4 mRNA transcript variant X18 NC_000008 Reference
XM_047421601 1 mRNA transcript variant X23 NC_000008 Reference
XM_011516939 4 mRNA transcript variant X21 NC_000008 Reference
XM_011516940 3 mRNA transcript variant X22 NC_000008 Reference