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TAB2

TGF-beta activated kinase 1 (MAP3K7) binding protein 2
General Information
Name TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Alias
  • TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
  • TAK1-binding protein 2
  • mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Gene_family Zinc fingers RANBP2-type
organism Homo sapiens
entrez_id 23118
location 6q25.1
transcript_count 13
exon_count 18
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Stringdb TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development; Zinc fingers RANBP2-type
    nextProt Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TAB2 BioGRID M GeneID BioGRID Proximity Label-MS
TAB2 BioGRID TRIM45 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TAB2 BioGRID PRNP GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
TAB2 BioGRID YWHAZ GeneID BioGRID Proximity Label-MS; Two-hybrid
TAB2 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
TAB2 BioGRID YWHAG GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
TAB2 BioGRID YWHAE GeneID BioGRID Proximity Label-MS
TAB2 BioGRID YWHAQ GeneID BioGRID Proximity Label-MS
TAB2 BioGRID SFN GeneID BioGRID Proximity Label-MS
TAB2 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TAB2 BioGRID EPHB2 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID ROR2 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID TRIM38 GeneID BioGRID Affinity Capture-Western; Co-localization
TAB2 BioGRID TRAF6 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TAB2 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID IRAK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TAB2 BioGRID TBX5 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID BAP1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID ORF6 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID TAB1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TAB2 BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID ISG15 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID SNX27 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID ANKRD10 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID RNF43 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID UBC GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
TAB2 BioGRID TRIM27 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TAB3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID EMILIN1 GeneID BioGRID Affinity Capture-MS; Two-hybrid
TAB2 BioGRID KCNE3 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID SCRN1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID BAG2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID AKAP1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
TAB2 BioGRID PRPS2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID CAMK2A GeneID BioGRID Affinity Capture-MS; Two-hybrid
TAB2 BioGRID RFPL4B GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID NOMO3 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID TMEM74 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID CARNMT1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID PKD1L2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID IL17RC GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID VPS33A GeneID BioGRID Proximity Label-MS
TAB2 BioGRID PCDHGB2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID MANSC1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID HSPA14 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID AGO2 GeneID BioGRID Affinity Capture-RNA
TAB2 BioGRID CARD8 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID TNF GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID SYNE3 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID SQSTM1 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID ZYX GeneID BioGRID Proximity Label-MS
TAB2 BioGRID VIM GeneID BioGRID Proximity Label-MS; Two-hybrid
TAB2 BioGRID PRPH GeneID BioGRID Proximity Label-MS
TAB2 BioGRID POLR2C GeneID BioGRID Proximity Label-MS
TAB2 BioGRID CLTA GeneID BioGRID Proximity Label-MS
TAB2 BioGRID NR3C1 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID TMEM192 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID TRIM25 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID Apc2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID FBXO42 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID ENTR1 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID TTN GeneID BioGRID Two-hybrid
TAB2 BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-RNA
TAB2 BioGRID USP15 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID CYLD GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
TAB2 BioGRID TRIM29 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID MIB1 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID KRT85 GeneID BioGRID Two-hybrid
TAB2 BioGRID ZFP64 GeneID BioGRID Two-hybrid
TAB2 BioGRID HSF2BP GeneID BioGRID Two-hybrid
TAB2 BioGRID FOSL1 GeneID BioGRID Two-hybrid
TAB2 BioGRID ZNF143 GeneID BioGRID Two-hybrid
TAB2 BioGRID TPM3 GeneID BioGRID Two-hybrid
TAB2 BioGRID VPS52 GeneID BioGRID Two-hybrid
TAB2 BioGRID BICD2 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID BICD1 GeneID BioGRID Proximity Label-MS
TAB2 BioGRID TNFRSF1A GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID SHARPIN GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID PPIL3 GeneID BioGRID Affinity Capture-Western; Protein-peptide; Reconstituted Complex
TAB2 BioGRID USP14 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID SNAI1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID RIPK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID RNF31 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID RNF4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID UBE2M GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID NLRP6 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID LMP-1 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TNIK GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID ESR1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TAB2 BioGRID AR GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID CCDC102B GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID CTDSP1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID USP18 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID F2R GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID MAPK14 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID MALT1 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID MCM2 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID LITAF GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID ARRB2 GeneID BioGRID Co-localization
TAB2 BioGRID CNTROB GeneID BioGRID Proximity Label-MS
TAB2 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID DBN1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID APP GeneID BioGRID Reconstituted Complex
TAB2 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TAB2 BioGRID Map3k7 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TAB2 BioGRID PIAS3 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID UBE2I GeneID BioGRID Biochemical Activity
TAB2 BioGRID SIK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID SIK3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TAB2 BioGRID TRIM22 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID NPM1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID CST9L GeneID BioGRID Two-hybrid
TAB2 BioGRID SLC19A3 GeneID BioGRID Two-hybrid
TAB2 BioGRID env GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID NUMBL GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TAB2 BioGRID ZBTB16 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TAB2 BioGRID TGM2 GeneID BioGRID Two-hybrid
TAB2 BioGRID PPP2CB GeneID BioGRID Two-hybrid
TAB2 BioGRID IKBKB GeneID BioGRID Biochemical Activity
TAB2 BioGRID GTF2I GeneID BioGRID Two-hybrid
TAB2 BioGRID FN1 GeneID BioGRID Two-hybrid
TAB2 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID BST2 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID DYNC2I2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TAB2 BioGRID MAP3K8 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TRIM5 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TBL1XR1 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID MBD3 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID NLK GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TAB2 BioGRID SIN3A GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID ATG13 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID NCOR1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TAB2 BioGRID ATG5 GeneID BioGRID Co-localization
TAB2 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western; Co-localization
TAB2 BioGRID NR2C2 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TGFBR1 GeneID BioGRID Affinity Capture-Luminescence
TAB2 BioGRID EDARADD GeneID BioGRID Affinity Capture-Western; Two-hybrid
TAB2 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID SMAD7 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TANK GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID PDLIM7 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID BNIP3P6 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID Trim30a GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID RBCK1 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TLR3 GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID ERBB4 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TAB2 BioGRID CHUK GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID TIRAP GeneID BioGRID Affinity Capture-MS
TAB2 BioGRID TRAF3IP1 GeneID BioGRID Two-hybrid
TAB2 BioGRID PPP6C GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID RIPK2 GeneID BioGRID Affinity Capture-Western
TAB2 Protein HDAC3 GeneID HPRD
TAB2 Protein TNFRSF11A GeneID HPRD
TAB2 Protein TAB1 GeneID HPRD
TAB2 Protein MAP3K7 GeneID HPRD
TAB2 Protein TRAF6 GeneID HPRD
TAB2 Protein TRAF2 GeneID HPRD
TAB2 Protein NR2C2 GeneID HPRD
TAB2 Protein IRAK1 GeneID HPRD
TAB2 Protein XIAP GeneID HPRD
TAB2 Protein EIF2AK2 GeneID HPRD
TAB2 BioGRID TAB2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TAB2 BioGRID TNFRSF11A GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID XIAP GeneID BioGRID Affinity Capture-Western
TAB2 BioGRID HDAC5 GeneID BioGRID Reconstituted Complex
TAB2 BioGRID HDAC3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TAB2 BioGRID TBL1X GeneID BioGRID Reconstituted Complex
TAB2 BioGRID NFKB1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TAB2 BioGRID HDAC1 GeneID BioGRID Reconstituted Complex
TAB2 BioGRID CS GeneID BioGRID Affinity Capture-MS
TAB2 None None None BIND An unspecified isoform of MAP3K7IP2 (TAB2) interacts with the CD82 (KAI1) promoter.
StringDB
A B experiments database textmining combined score hadb nhadb
TAB2 PPARG 0 0 156 169 1 2
TAB2 UBE3A 0 0 184 201 1 1
TAB2 AKT1 0 0 323 370 1 2
TAB2 IRAK1BP1 0 0 261 292 1 1
TAB2 CSF2 0 0 161 161 1 1
TAB2 LY96 0 600 336 723 1 1
TAB2 SUMO1 0 0 156 155 1 1
TAB2 FAS 0 0 129 152 1 2
TAB2 CARD8 273 0 0 282 1 1
TAB2 CD4 0 0 261 261 1 2
TAB2 INPP5D 0 0 276 276 1 1
TAB2 ENSG00000279392 0 0 181 189 1 1
TAB2 IKBKB 270 900 694 986 1 2
TAB2 NLRC4 0 0 233 232 1 2
TAB2 DROSHA 0 0 166 165 1 1
TAB2 KCNJ6 0 0 143 175 1 1
TAB2 XIAP 270 900 370 952 1 2
TAB2 C9orf89 0 0 112 266 1 1
TAB2 MYOF 0 0 66 426 1 1
TAB2 WWOX 0 0 113 151 1 1
TAB2 TMEM9B 0 0 194 194 1 1
TAB2 UBQLN1 0 0 146 176 1 1
TAB2 BCL6 0 0 141 162 1 1
TAB2 OTUD7A 0 0 44 209 1 1
TAB2 GSK3A 0 0 0 179 1 1
TAB2 PDLIM2 0 0 181 187 1 1
TAB2 MALT1 486 600 580 908 1 1
TAB2 CXCL10 0 0 166 165 1 2
TAB2 USP25 0 0 240 259 1 1
TAB2 BTBD2 0 0 0 270 1 1
TAB2 CYLD 114 900 606 966 1 1
TAB2 PIKFYVE 0 0 74 173 1 2
TAB2 PHF20 0 0 825 830 1 1
TAB2 MAP3K1 0 0 490 502 1 1
TAB2 PYCARD 0 0 181 181 1 2
TAB2 TRIM10 0 0 81 215 1 1
TAB2 IMMP1L 0 0 90 185 1 1
TAB2 TLR9 0 0 407 427 1 2
TAB2 IRF3 0 0 503 506 1 2
TAB2 UBA7 0 0 94 150 1 1
TAB2 EMILIN1 265 0 0 265 1 1
TAB2 USP2 0 900 207 919 1 1
TAB2 TNFSF11 0 0 358 358 1 2
TAB2 KDM6A 0 0 55 247 1 1
TAB2 RABEP2 0 0 74 274 1 1
TAB2 IL36B 0 0 43 191 1 1
TAB2 BBOX1 0 0 291 335 1 1
TAB2 STAMBP 0 0 211 211 1 1
TAB2 IRF8 0 0 155 154 1 1
TAB2 PINX1 0 0 67 175 1 1
TAB2 SRC 0 0 451 487 1 2
TAB2 ZRANB2 0 0 109 151 1 1
TAB2 SIN3B 0 0 0 183 1 1
TAB2 CDC42 0 0 134 159 1 2
TAB2 SMURF2 0 0 166 202 1 1
TAB2 USP8 0 0 130 173 1 1
TAB2 TLR3 270 600 513 867 1 2
TAB2 TRIM28 0 0 141 309 1 2
TAB2 SH3RF3 0 0 0 272 1 1
TAB2 ENAH 0 0 270 270 1 1
TAB2 PPP4R1 0 0 327 327 1 1
TAB2 WWP2 0 0 127 251 1 1
TAB2 AKIRIN1 0 0 75 153 1 1
TAB2 TP53INP1 0 0 89 168 1 2
TAB2 TRIM14 0 0 103 568 1 1
TAB2 DCAF11 0 0 73 326 1 1
TAB2 NRG1 0 0 384 384 1 2
TAB2 TBK1 0 0 458 582 1 2
TAB2 TICAM2 0 600 204 701 1 1
TAB2 CD82 0 0 605 605 1 1
TAB2 PIAS4 0 0 289 316 1 1
TAB2 STX17 0 0 0 173 1 2
TAB2 JAK1 0 0 122 241 1 2
TAB2 SKP1 0 0 193 194 1 2
TAB2 F2R 270 0 391 536 1 1
TAB2 TRIM29 270 0 202 598 1 1
TAB2 TGFB1 0 900 66 904 1 2
TAB2 ECI2 0 0 53 269 1 1
TAB2 STAT5B 0 0 144 177 1 1
TAB2 TRRAP 0 0 310 322 1 1
TAB2 HACE1 0 0 97 229 1 1
TAB2 RIPK3 0 0 425 470 1 2
TAB2 IFIT1 0 0 97 200 1 1
TAB2 RB1 0 0 72 168 1 2
TAB2 PPIL3 270 0 73 294 1 1
TAB2 PITPNB 0 0 94 150 1 1
TAB2 USP7 0 0 203 241 1 1
TAB2 RBM25 0 0 49 193 1 1
TAB2 FDFT1 0 0 45 412 1 1
TAB2 MAP2K2 0 0 74 156 1 1
TAB2 TMEM189-UBE2V1 0 0 0 181 1 1
TAB2 SMAD6 0 900 163 912 1 1
TAB2 BMPR2 0 900 73 915 1 1
TAB2 NUMBL 413 0 800 878 1 1
TAB2 MAP4K3 0 0 74 171 1 1
TAB2 TRAF3IP2 0 0 180 179 1 1
TAB2 UBB 800 650 108 936 1 1
TAB2 PDPK1 0 600 0 609 1 2
TAB2 AGTR1 0 0 46 159 1 1
TAB2 NKIRAS1 0 0 61 204 1 1
TAB2 MRPS18A 0 0 91 190 1 1
TAB2 NCOR1 486 900 988 999 1 1
TAB2 ERC1 0 900 485 946 1 1
TAB2 CBL 0 0 155 154 1 1
TAB2 PDLIM7 270 0 49 276 1 1
TAB2 IRAK2 0 600 604 855 1 1
TAB2 UBE2I 270 0 166 371 1 1
TAB2 ZNF569 0 0 323 323 1 1
TAB2 JUND 0 0 113 203 1 1
TAB2 IFNAR1 0 0 134 152 1 1
TAB2 MAP4K1 0 0 93 202 1 1
TAB2 MAP3K14 0 900 250 921 1 1
TAB2 TNFAIP3 0 900 392 946 1 2
TAB2 IREB2 0 0 193 232 1 1
TAB2 NFKB2 0 0 456 616 1 1
TAB2 TCP1 0 0 0 187 1 1
TAB2 RELB 0 0 455 455 1 2
TAB2 GPS2 0 0 397 396 1 1
TAB2 RFPL4B 273 0 0 287 1 1
TAB2 USP19 0 0 150 185 1 1
TAB2 STRN 0 0 61 414 1 1
TAB2 MAPK1 0 0 155 169 1 2
TAB2 IRF7 0 0 419 423 1 1
TAB2 RNF41 0 0 155 272 1 1
TAB2 SOCS1 0 0 422 434 1 1
TAB2 BTK 0 0 208 260 1 1
TAB2 NEDD4L 0 0 150 198 1 1
TAB2 TNF 686 900 517 984 1 2
TAB2 RNF4 486 0 108 521 1 1
TAB2 TANK 270 0 414 589 1 2
TAB2 TIRAP 157 0 556 636 1 1
TAB2 COL8A1 0 0 0 388 1 1
TAB2 MEF2C 0 0 132 181 1 1
TAB2 VPS36 0 0 160 159 1 1
TAB2 USP5 0 0 194 194 1 1
TAB2 SIN3A 270 0 0 378 1 1
TAB2 UBE2W 0 0 124 234 1 1
TAB2 HIPK3 0 0 0 183 1 1
TAB2 CASP2 0 0 113 168 1 1
TAB2 STRN3 0 0 0 161 1 1
TAB2 NAIP 0 0 147 181 1 1
TAB2 NFAT5 0 0 108 151 1 1
TAB2 RNF135 0 0 187 203 1 1
TAB2 USP14 270 0 159 361 1 2
TAB2 DDX3X 0 0 74 255 1 1
TAB2 ITCH 0 0 325 354 1 1
TAB2 NXPE4 0 0 118 180 1 1
TAB2 CCNT2 0 0 271 573 1 1
TAB2 PDZRN3 0 0 0 174 1 1
TAB2 SPI1 0 0 294 294 1 1
TAB2 LYN 0 0 134 209 1 1
TAB2 CTSK 0 0 180 179 1 2
TAB2 UBE2D2 0 0 181 237 1 1
TAB2 COPS5 0 0 184 183 1 1
TAB2 ESR1 675 0 800 933 1 2
TAB2 TOR3A 0 0 90 182 1 1
TAB2 IFNB1 0 0 459 460 1 1
TAB2 IRF5 0 0 341 352 1 1
TAB2 HMGB1 0 0 162 192 1 2
TAB2 MAP3K5 0 0 294 333 1 1
TAB2 OPTN 0 0 282 282 1 2
TAB2 SMAD7 270 900 834 986 1 1
TAB2 CACTIN 0 0 181 237 1 1
TAB2 TNIK 270 0 75 340 1 1
TAB2 TLR8 0 0 325 337 1 1
TAB2 EDAR 0 0 307 307 1 1
TAB2 CALCOCO2 0 0 155 346 1 2
TAB2 MAP2K6 0 900 464 950 1 1
TAB2 ATG5 273 0 164 395 1 2
TAB2 IRF1 0 0 204 204 1 2
TAB2 C2orf68 0 0 151 212 1 1
TAB2 SP3 0 0 0 165 1 1
TAB2 HIPK2 0 900 63 922 1 2
TAB2 DYRK1A 0 0 0 234 1 1
TAB2 USP18 270 0 123 340 1 1
TAB2 TGFBR1 270 900 447 959 1 1
TAB2 NFKBIB 0 0 325 367 1 1
TAB2 ADAM17 0 0 138 157 1 1
TAB2 SLC15A3 0 0 112 150 1 1
TAB2 UBC 981 650 252 995 1 2
TAB2 PIAS3 270 0 181 414 1 1
TAB2 BTBD1 0 0 87 310 1 1
TAB2 STX7 0 0 0 195 1 2
TAB2 LATS1 0 0 96 172 1 1
TAB2 ATP8A1 0 0 0 296 1 1
TAB2 MAP3K12 0 0 73 190 1 1
TAB2 OSBPL9 0 0 60 159 1 1
TAB2 FN1 131 0 160 238 1 2
TAB2 PSMD14 0 0 135 153 1 1
TAB2 IKBKG 653 900 954 998 1 1
TAB2 MAP4K4 0 900 166 921 1 1
TAB2 PWP1 0 0 74 326 1 1
TAB2 ATM 0 0 240 250 1 2
TAB2 TRIM32 0 0 142 291 1 1
TAB2 TYRO3 0 0 66 167 1 1
TAB2 AXIN1 0 0 66 159 1 1
TAB2 LITAF 270 0 74 295 1 1
TAB2 SIK3 270 0 365 517 1 1
TAB2 TRIM26 0 0 125 179 1 1
TAB2 ARFGEF1 0 0 0 152 1 1
TAB2 DYRK1B 0 0 0 157 1 1
TAB2 AREL1 0 0 52 151 1 1
TAB2 TRAIP 0 0 124 176 1 1
TAB2 HIVEP2 0 0 124 253 1 1
TAB2 FAIM2 0 0 55 156 1 1
TAB2 TGFBR2 0 900 94 912 1 1
TAB2 OTUD5 0 0 246 262 1 1
TAB2 TRAT1 0 0 390 390 1 1
TAB2 NPM1 270 0 0 270 1 1
TAB2 IRAK4 0 800 681 942 1 1
TAB2 METTL15 0 0 120 197 1 1
TAB2 GFAP 0 900 47 900 1 2
TAB2 STRAP 0 900 48 900 1 1
TAB2 IL10 0 0 283 282 1 2
TAB2 UBE2S 0 0 235 254 1 1
TAB2 PTEN 0 0 155 173 1 2
TAB2 BMPR1A 0 900 0 906 1 1
TAB2 DSTYK 0 0 73 226 1 1
TAB2 NLRP6 270 0 166 365 1 1
TAB2 IRF4 0 0 161 161 1 1
TAB2 BST2 270 0 124 514 1 1
TAB2 TRAFD1 0 0 193 193 1 1
TAB2 TNFRSF11A 270 0 84 302 1 1
TAB2 MAPK7 0 0 250 263 1 1
TAB2 CD200 0 0 270 270 1 1
TAB2 NFATC1 0 0 260 260 1 2
TAB2 TRAF7 0 0 288 387 1 1
TAB2 SDCCAG3 196 0 0 196 1 1
TAB2 UBE2M 270 0 45 273 1 1
TAB2 SYK 0 0 193 246 1 2
TAB2 NFKBIA 0 650 603 871 1 2
TAB2 MAP3K3 0 900 391 936 1 1
TAB2 CD164 0 0 0 237 1 1
TAB2 NLK 270 900 248 946 1 1
TAB2 BMP4 0 900 53 902 1 1
TAB2 ZC3H12A 0 0 251 268 1 1
TAB2 PPP1R9A 0 0 322 321 1 1
TAB2 UBA52 800 650 0 927 1 1
TAB2 MAPK10 0 0 96 220 1 2
TAB2 UIMC1 0 0 287 286 1 1
TAB2 CNTN2 0 0 411 411 1 1
TAB2 KAT5 0 0 537 545 1 1
TAB2 MAPK14 270 900 307 947 1 2
TAB2 NR2C2 678 0 573 894 1 1
TAB2 ENSG00000268643 0 0 0 179 1 1
TAB2 RNF151 0 0 0 174 1 1
TAB2 TRIM56 0 0 289 354 1 1
TAB2 TRIM22 270 0 218 517 1 1
TAB2 CREBRF 0 0 93 156 1 1
TAB2 EDA2R 0 0 94 150 1 1
TAB2 PRKCQ 0 600 151 654 1 2
TAB2 ATG12 0 0 140 199 1 2
TAB2 PPM1B 0 0 95 167 1 1
TAB2 TNFSF13B 0 0 246 245 1 1
TAB2 PTGS2 0 0 161 161 1 2
TAB2 SMURF1 0 0 167 203 1 1
TAB2 CASP3 0 0 232 241 1 2
TAB2 PGLYRP1 0 0 394 421 1 1
TAB2 NLRP3 0 0 257 256 1 2
TAB2 LNX1 0 0 0 174 1 1
TAB2 REL 0 0 418 479 1 2
TAB2 CXCL1 0 0 134 170 1 2
TAB2 UBE2V1 0 900 736 975 1 1
TAB2 HDAC1 270 0 95 311 1 2
TAB2 MAP3K10 0 0 54 153 1 1
TAB2 RIPK1 835 900 987 999 1 2
TAB2 TRIM68 0 0 118 189 1 1
TAB2 DTX3L 0 0 49 308 1 1
TAB2 CSF1 0 0 170 169 1 1
TAB2 LTBR 0 0 234 234 1 1
TAB2 TMEM115 0 0 0 193 1 1
TAB2 ZRANB3 0 0 181 181 1 1
TAB2 IFIT1B 0 0 0 150 1 1
TAB2 CEBPB 0 0 202 202 1 2
TAB2 ATG16L1 0 0 181 197 1 2
TAB2 CIITA 0 0 129 150 1 1
TAB2 ECSIT 0 0 363 529 1 1
TAB2 NOD2 0 600 415 758 1 2
TAB2 CHUK 270 900 734 988 1 1
TAB2 ZZEF1 0 0 107 197 1 1
TAB2 IL1RAP 0 0 218 218 1 1
TAB2 NPLOC4 0 0 661 711 1 1
TAB2 GSK3B 0 0 89 269 1 2
TAB2 SIK1 270 0 43 271 1 1
TAB2 CDC34 0 0 126 169 1 1
TAB2 S100B 0 900 0 900 1 1
TAB2 ARRB2 393 0 74 474 1 1
TAB2 BMPR1B 0 900 0 906 1 1
TAB2 STAMBPL1 0 0 310 309 1 1
TAB2 PPP6C 270 0 416 555 1 1
TAB2 RPS27A 927 650 212 978 1 1
TAB2 TAPBPL 0 0 73 488 1 1
TAB2 BTRC 0 0 322 340 1 1
TAB2 TIFA 0 600 0 602 1 1
TAB2 FAF1 0 0 102 261 1 1
TAB2 TNIP1 0 0 279 363 1 1
TAB2 IRAK3 0 0 456 491 1 1
TAB2 TNIP2 0 0 315 315 1 1
TAB2 BIRC7 0 0 66 295 1 1
TAB2 STAT5A 0 0 166 199 1 1
TAB2 APLP1 0 0 66 166 1 1
TAB2 TTLL5 0 0 72 355 1 1
TAB2 FOS 0 0 282 287 1 2
TAB2 TTLL4 0 0 0 173 1 1
TAB2 NOD1 0 600 403 755 1 2
TAB2 CARD11 0 600 391 753 1 1
TAB2 SHARPIN 128 0 560 603 1 1
TAB2 PGLYRP3 0 0 0 207 1 1
TAB2 TBKBP1 0 0 205 205 1 1
TAB2 USP20 0 0 201 220 1 1
TAB2 TRAF3 0 800 599 929 1 2
TAB2 LRRK2 0 0 85 167 1 2
TAB2 TM9SF2 0 0 74 150 1 1
TAB2 TOLLIP 0 0 456 549 1 1
TAB2 PIAS1 0 0 96 168 1 1
TAB2 PIK3CB 0 0 101 152 1 1
TAB2 TLR2 0 0 425 435 1 2
TAB2 MAPK11 0 900 164 916 1 1
TAB2 DUSP1 0 0 217 217 1 1
TAB2 CCDC170 0 0 207 207 1 1
TAB2 TLR6 0 0 325 354 1 1
TAB2 IL2 0 0 174 173 1 1
TAB2 VSIG4 0 0 0 388 1 1
TAB2 OTUD7B 0 900 391 947 1 1
TAB2 AKIRIN2 0 0 90 190 1 1
TAB2 BECN1 486 0 833 927 1 2
TAB2 WRNIP1 0 0 134 253 1 1
TAB2 RELA 0 650 468 805 1 2
TAB2 TRAF3IP1 272 0 0 277 1 1
TAB2 BCL2L1 0 0 206 206 1 2
TAB2 C1R 0 0 0 286 1 1
TAB2 NFKB1 270 650 322 864 1 2
TAB2 TAB3 608 800 989 938 1 1
TAB2 TLR10 0 0 227 270 1 1
TAB2 ZRANB1 0 0 391 587 1 1
TAB2 ENSG00000250349 0 0 579 579 1 1
TAB2 ZAP70 0 0 123 180 1 1
TAB2 TRIM25 0 0 360 389 1 1
TAB2 ATP8A2 0 0 59 309 1 1
TAB2 PELI2 0 0 122 310 1 1
TAB2 MAP2K7 0 900 149 932 1 1
TAB2 UBE2V2 0 0 335 623 1 1
TAB2 RGMB 0 900 0 900 1 1
TAB2 CD14 0 600 71 617 1 1
TAB2 POTEE 0 0 430 430 1 1
TAB2 GAPDH 0 0 235 235 1 2
TAB2 ATG14 0 0 123 153 1 2
TAB2 RHNO1 0 0 90 229 1 1
TAB2 SMAD2 0 0 217 230 1 2
TAB2 PML 0 0 162 178 1 2
TAB2 TLR4 0 600 519 804 1 2
TAB2 CREB1 0 0 202 219 1 2
TAB2 USP9X 0 0 115 184 1 1
TAB2 TGFB3 0 900 67 902 1 1
TAB2 CCL5 0 0 181 181 1 2
TAB2 IFNG 0 0 112 192 1 2
TAB2 BIRC2 0 600 718 911 1 1
TAB2 GZMM 0 0 325 325 1 1
TAB2 KHDRBS1 0 0 165 165 1 1
TAB2 WWP1 0 0 142 230 1 1
TAB2 CTDSPL2 0 0 0 357 1 1
TAB2 CREBBP 0 0 156 185 1 1
TAB2 TRIM9 0 0 122 211 1 1
TAB2 UBE2D3 0 0 351 417 1 1
TAB2 RSPO2 0 0 0 250 1 1
TAB2 ACO2 0 0 0 397 1 1
TAB2 HDDC2 0 0 144 234 1 1
TAB2 TRIP12 0 0 0 154 1 1
TAB2 POLR2A 0 0 0 256 1 1
TAB2 NRG2 0 0 242 241 1 1
TAB2 RPS3 0 0 181 186 1 1
TAB2 KCNG4 0 0 56 157 1 1
TAB2 MYT1L 0 0 191 241 1 1
TAB2 JARID2 0 0 195 261 1 1
TAB2 RAD23A 0 0 181 195 1 1
TAB2 MTOR 0 0 134 243 1 2
TAB2 NLRP1 0 0 181 181 1 1
TAB2 ARAF 0 0 59 159 1 1
TAB2 CD40LG 0 0 230 229 1 1
TAB2 NOTCH1 0 0 211 211 1 2
TAB2 USP21 0 900 74 904 1 1
TAB2 TRAF4 0 0 320 523 1 1
TAB2 PIDD1 0 0 180 192 1 1
TAB2 HFE2 0 900 0 900 1 1
TAB2 TNFRSF1A 678 900 668 988 1 1
TAB2 TRIM71 0 0 96 251 1 1
TAB2 TRIM37 0 0 95 352 1 1
TAB2 STAT1 0 0 245 244 1 2
TAB2 WDR34 270 0 438 572 1 1
TAB2 IL6 0 0 416 416 1 2
TAB2 TBL1XR1 270 0 384 541 1 1
TAB2 NLRC3 0 0 166 180 1 1
TAB2 SUMO4 0 0 537 538 1 1
TAB2 NUDCD1 270 0 0 270 1 1
TAB2 PPP1R12A 0 0 0 157 1 1
TAB2 PPP4C 0 0 294 294 1 1
TAB2 CXorf57 0 0 91 192 1 1
TAB2 NFKBID 0 0 261 261 1 1
TAB2 SULF2 0 0 0 185 1 1
TAB2 OTUD3 0 0 97 159 1 1
TAB2 SEC24B 0 0 0 215 1 1
TAB2 MAPK13 0 650 123 686 1 1
TAB2 CXCL8 0 0 323 323 1 2
TAB2 RNF11 0 0 180 186 1 1
TAB2 F11 0 0 294 294 1 1
TAB2 IL1B 0 0 504 504 1 2
TAB2 ZFP64 215 0 0 215 1 1
TAB2 TRIM27 0 0 323 341 1 1
TAB2 NEDD4 0 0 164 182 1 2
TAB2 TRAF5 0 600 601 856 1 1
TAB2 CNPY4 0 0 185 185 1 1
TAB2 NXPE2 0 0 134 198 1 1
TAB2 PRKCB 0 0 167 186 1 2
TAB2 IKBKE 0 0 270 465 1 1
TAB2 ACSL5 0 0 0 192 1 1
TAB2 ERBB2IP 0 0 95 171 1 1
TAB2 TRIM4 0 0 140 195 1 1
TAB2 TRIM13 0 0 170 273 1 1
TAB2 APP 0 0 439 439 1 2
TAB2 SOCS7 0 0 0 189 1 1
TAB2 CTNNB1 0 0 202 202 1 2
TAB2 HRAS 0 0 134 172 1 2
TAB2 CRYL1 0 0 66 321 1 1
TAB2 HUWE1 0 0 169 310 1 1
TAB2 CALM3 117 0 62 150 1 1
TAB2 TRIM6-TRIM34 0 0 81 175 1 1
TAB2 PDCD6 0 0 96 238 1 1
TAB2 G3BP2 0 0 81 256 1 1
TAB2 APAF1 0 0 128 150 1 2
TAB2 JAK2 0 0 47 186 1 2
TAB2 NLRC5 0 0 147 177 1 1
TAB2 VAMP8 0 0 67 161 1 2
TAB2 TRIM8 0 0 181 337 1 1
TAB2 STAT3 0 0 241 257 1 2
TAB2 ST18 0 0 137 269 1 1
TAB2 AGO2 0 0 134 175 1 2
TAB2 MKKS 0 0 292 544 1 1
TAB2 TAOK2 0 0 322 337 1 1
TAB2 SIVA1 0 0 108 158 1 1
TAB2 TRIM23 0 0 242 264 1 1
TAB2 MYD88 0 600 803 941 1 2
TAB2 MAP3K13 0 0 88 179 1 1
TAB2 EGFR 0 0 166 165 1 2
TAB2 CFLAR 0 0 378 399 1 2
TAB2 NEDD8 0 0 162 176 1 2
TAB2 SARM1 0 0 325 442 1 1
TAB2 FADD 0 0 503 506 1 2
TAB2 GPM6B 0 0 150 316 1 1
TAB2 TRIM24 0 0 82 177 1 1
TAB2 BTBD6 0 0 0 188 1 1
TAB2 MYH14 0 0 0 248 1 1
TAB2 MDM2 0 0 181 199 1 2
TAB2 TP53 0 0 260 260 1 2
TAB2 NFKBIZ 0 0 268 268 1 1
TAB2 EDA 0 0 60 321 1 1
TAB2 EDARADD 270 0 624 714 1 1
TAB2 ZBP1 0 0 125 161 1 1
TAB2 ZNF44 0 0 324 323 1 1
TAB2 MAP3K7 913 900 987 999 1 2
TAB2 NLRP4 0 0 142 158 1 1
TAB2 RREB1 0 0 108 266 1 1
TAB2 TTLL10 0 0 70 230 1 1
TAB2 TRAF1 0 0 555 658 1 1
TAB2 CARD9 0 0 241 240 1 1
TAB2 SNAP23 0 0 94 159 1 1
TAB2 RAF1 0 0 81 161 1 2
TAB2 IRAK1 875 900 803 997 1 1
TAB2 NCOR2 0 0 277 731 1 1
TAB2 UBD 0 0 342 353 1 1
TAB2 ZNF501 0 0 324 323 1 1
TAB2 TAX1BP1 0 0 340 368 1 2
TAB2 HECA 0 0 0 198 1 1
TAB2 IL17RC 130 0 90 174 1 1
TAB2 HDAC5 270 0 0 270 1 1
TAB2 UBA1 0 0 165 251 1 1
TAB2 CCNT1 0 0 0 211 1 1
TAB2 TNFRSF12A 0 0 172 171 1 1
TAB2 FLNA 131 0 112 195 1 1
TAB2 PDZRN4 0 0 0 174 1 1
TAB2 HDAC3 270 0 55 280 1 2
TAB2 SMAD4 0 0 182 203 1 2
TAB2 MAP2K1 0 0 164 238 1 1
TAB2 MAP3K8 270 0 324 489 1 1
TAB2 CARD10 0 0 95 158 1 1
TAB2 DHX58 0 0 213 213 1 1
TAB2 RBCK1 270 0 518 653 1 1
TAB2 NLRP12 0 0 163 163 1 1
TAB2 SERINC1 0 0 0 151 1 1
TAB2 TLR1 0 0 376 392 1 1
TAB2 CDC14A 0 0 386 386 1 1
TAB2 UBE2D1 0 0 325 363 1 1
TAB2 IGF1R 0 0 95 154 1 2
TAB2 TRIM33 0 0 71 178 1 1
TAB2 IL36G 0 0 0 189 1 1
TAB2 COG1 0 0 74 340 1 1
TAB2 IFNA1 0 0 289 288 1 1
TAB2 WNT5A 0 0 170 171 1 2
TAB2 IL18 0 0 283 282 1 2
TAB2 HIPK1 0 0 0 166 1 1
TAB2 IKBKAP 0 0 49 369 1 1
TAB2 RNF125 0 0 150 172 1 1
TAB2 MYC 0 0 266 266 1 2
TAB2 IL1R1 0 0 518 520 1 1
TAB2 UBXN7 0 0 0 189 1 1
TAB2 CTDSP1 131 0 0 281 1 1
TAB2 EVA1B 0 0 139 283 1 1
TAB2 RUVBL2 94 0 306 344 1 1
TAB2 USP15 270 0 234 468 1 1
TAB2 GLDC 0 0 44 412 1 1
TAB2 SLC15A4 0 0 115 166 1 1
TAB2 TRAF2 835 900 601 996 1 2
TAB2 OFD1 0 0 0 190 1 2
TAB2 TAB1 897 900 989 999 1 1
TAB2 RNF168 0 0 107 196 1 1
TAB2 AP4M1 0 0 52 324 1 1
TAB2 MEFV 0 0 253 267 1 1
TAB2 PELI1 0 900 310 943 1 1
TAB2 PCSK1 0 0 193 196 1 1
TAB2 ETS1 0 0 120 175 1 1
TAB2 SOS2 0 0 0 156 1 1
TAB2 SENP1 0 0 135 156 1 1
TAB2 IL17A 0 0 287 286 1 2
TAB2 RGMA 0 900 0 900 1 1
TAB2 BMP2 0 900 48 901 1 1
TAB2 EGF 0 0 152 151 1 2
TAB2 TLR7 0 0 421 436 1 2
TAB2 MAPK9 0 0 231 335 1 2
TAB2 ZNF7 0 0 289 288 1 1
TAB2 TRAF6 898 900 989 999 1 2
TAB2 XPO5 0 0 135 159 1 1
TAB2 PDCD4 0 0 181 198 1 2
TAB2 TRIM5 270 0 801 852 1 1
TAB2 DICER1 0 0 204 221 1 1
TAB2 ALPK1 0 600 0 600 1 1
TAB2 CISH 0 0 180 179 1 1
TAB2 ZNF316 0 0 181 217 1 1
TAB2 FBXO11 0 0 46 218 1 1
TAB2 TDP2 0 0 56 181 1 1
TAB2 HBZ 0 0 141 235 1 1
TAB2 IFIH1 0 0 294 306 1 1
TAB2 DIABLO 0 0 285 284 1 2
TAB2 SPATA2 0 0 252 252 1 1
TAB2 OTUB1 0 0 249 248 1 1
TAB2 IL1F10 0 0 108 246 1 1
TAB2 MAP2K4 0 900 290 933 1 1
TAB2 USP36 0 0 139 228 1 1
TAB2 CD79B 0 0 99 161 1 1
TAB2 MUT 0 0 123 156 1 1
TAB2 CTDSPL 0 0 82 241 1 1
TAB2 MAPK8 0 0 391 474 1 2
TAB2 SKP2 0 0 86 335 1 2
TAB2 CBFA2T3 0 0 181 181 1 1
TAB2 SH3RF1 0 0 225 412 1 1
TAB2 MB21D1 0 0 184 183 1 1
TAB2 VCPIP1 0 0 0 196 1 1
TAB2 NRG4 0 0 295 295 1 1
TAB2 WAC 0 0 82 542 1 1
TAB2 BCL2L13 0 0 90 229 1 2
TAB2 ZNF763 0 0 324 323 1 1
TAB2 TRIM21 0 0 323 354 1 1
TAB2 FKBP4 0 0 85 358 1 1
TAB2 CDK6 0 0 134 156 1 2
TAB2 DDX58 0 0 427 426 1 1
TAB2 AIM2 0 0 205 205 1 2
TAB2 DDX41 0 0 166 165 1 1
TAB2 MAPKAPK2 0 0 183 200 1 1
TAB2 MAP3K9 0 0 123 215 1 1
TAB2 CRX 0 0 0 158 1 1
TAB2 WNT1 0 900 67 902 1 2
TAB2 TRADD 0 900 653 966 1 1
TAB2 MAVS 0 800 342 862 1 2
TAB2 SRGN 0 0 0 410 1 1
TAB2 IL1A 0 0 261 261 1 1
TAB2 LGALS4 0 0 327 327 1 1
TAB2 ZNF365 0 0 234 234 1 1
TAB2 RNF31 123 0 610 644 1 1
TAB2 MAP3K11 0 0 84 180 1 1
TAB2 BBS10 0 0 0 187 1 1
TAB2 CUL1 0 0 166 185 1 1
TAB2 ZNF436 0 0 324 323 1 1
TAB2 CASP8 0 0 457 464 1 2
TAB2 RC3H1 0 0 120 169 1 1
TAB2 CCL2 0 0 219 219 1 2
TAB2 TRIM62 0 0 193 225 1 1
TAB2 OTULIN 0 0 377 381 1 1
TAB2 NEK10 0 0 125 166 1 1
TAB2 BIRC3 0 600 367 800 1 1
TAB2 SMAD3 0 0 170 202 1 2
TAB2 RAP1B 0 0 90 182 1 1
TAB2 IL4 0 0 194 194 1 1
TAB2 EP300 0 0 161 191 1 2
TAB2 MAPK3 0 0 232 245 1 2
TAB2 SQSTM1 0 0 195 195 1 2
TAB2 TRAM1 0 0 96 192 1 1
TAB2 ATG13 270 0 67 289 1 2
TAB2 C9orf41 274 0 0 274 1 1
TAB2 ACTB 0 0 223 223 1 2
TAB2 CD40 0 0 367 371 1 2
TAB2 NLRX1 0 0 246 245 1 2
TAB2 RFK 0 0 161 161 1 1
TAB2 SOX2 0 0 347 446 1 2
TAB2 PSEN1 0 0 296 296 1 2
TAB2 SETDB1 0 0 155 154 1 1
TAB2 HSP90AA1 196 0 181 313 1 2
TAB2 FOSL1 130 0 62 156 1 1
TAB2 SCML4 0 0 95 157 1 1
TAB2 ENSG00000258724 0 0 0 188 1 1
TAB2 ENOSF1 0 0 74 151 1 1
TAB2 RNF8 0 0 172 191 1 1
TAB2 MID1 0 0 171 204 1 1
TAB2 ZNF711 0 0 252 252 1 1
TAB2 UNC93B1 0 0 184 183 1 1
TAB2 SMDT1 0 0 211 231 1 1
TAB2 MLKL 0 0 391 440 1 2
TAB2 BCL10 0 600 532 806 1 1
TAB2 TRIM31 0 0 124 163 1 1
TAB2 TMEM244 0 0 181 181 1 1
TAB2 BTBD3 0 0 0 188 1 1
TAB2 SLC15A1 0 0 394 394 1 1
TAB2 TLR5 0 0 346 371 1 1
TAB2 CDKN2AIPNL 0 0 155 154 1 1
TAB2 N4BP1 0 0 90 195 1 1
TAB2 UBE2N 0 900 725 981 1 1
TAB2 IL36A 0 0 0 190 1 1
TAB2 HNRNPH1 373 0 0 373 1 1
TAB2 MBD3 270 0 0 270 1 1
TAB2 PARP1 0 0 140 158 1 2
TAB2 AR 486 0 103 526 1 2
TAB2 UBE2L3 0 0 181 189 1 1
TAB2 FBXO36 0 0 114 293 1 1
TAB2 TNFRSF13C 0 0 225 224 1 1
TAB2 ATP1B3 0 0 71 429 1 1
TAB2 RIPK2 270 800 558 934 1 2
TAB2 CD8A 0 0 210 210 1 1
TAB2 BMP6 0 0 45 193 1 1
TAB2 APBB1 0 0 609 609 1 1
TAB2 P2RY1 0 0 226 226 1 1
TAB2 PUM2 0 0 75 218 1 1
TAB2 EIF2AK2 213 0 108 277 1 2
TAB2 SULF1 0 0 0 188 1 1
TAB2 LRIF1 0 0 91 162 1 1
TAB2 IL36RN 0 0 53 200 1 1
TAB2 IL37 0 0 63 207 1 1
TAB2 LTA 0 0 82 152 1 1
TAB2 TBL1X 270 0 357 521 1 1
TAB2 USP4 0 900 268 933 1 1
TAB2 LCK 0 0 124 181 1 1
TAB2 IL17RA 0 0 181 181 1 1
TAB2 UBXN8 0 0 92 183 1 1
TAB2 PELI3 0 0 124 306 1 1
TAB2 NFKBIE 0 0 259 258 1 1
TAB2 TICAM1 0 600 413 758 1 2
TAB2 ABI1 0 0 0 183 1 1
TAB2 TRIM11 0 0 143 350 1 1
TAB2 ZNF629 0 0 324 323 1 1
TAB2 TMEM173 0 0 130 179 1 1
TAB2 TNIP3 0 0 194 204 1 1
TAB2 JUN 0 0 456 512 1 2
TAB2 AMFR 0 0 307 307 1 1
TAB2 MAPK12 0 650 151 701 1 1
TAB2 ENSG00000173366 0 0 404 424 1 1
TAB2 UBA6 0 0 74 169 1 1
TAB2 MYH7B 0 0 0 248 1 1
TAB2 TRIM17 0 0 279 368 1 1
TAB2 RC3H2 0 0 108 159 1 1
TAB2 MAP2K3 0 900 406 944 1 1
TAB2 JAK3 0 0 0 179 1 1
TAB2 ERBB4 270 900 950 996 1 1
TAB2 TNFSF10 0 0 155 154 1 2
TAB2 HSPA1A 116 0 89 160 1 1
TAB2 CASP1 0 0 283 291 1 2
TAB2 RLF 0 0 123 625 1 1
TAB2 TRIM38 270 0 578 685 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0070530 Molecular Function K63-linked polyubiquitin modification-dependent protein binding enables IBA
GO:0070530 Molecular Function K63-linked polyubiquitin modification-dependent protein binding enables IDA
GO:0060090 Molecular Function molecular adaptor activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0043130 Molecular Function ubiquitin binding enables IEA
GO:0008270 Molecular Function zinc ion binding enables IDA
GO:0042742 Biological Process defense response to bacterium involved_in IDA
GO:0007507 Biological Process heart development involved_in IMP
GO:0006954 Biological Process inflammatory response involved_in IDA
GO:0010507 Biological Process negative regulation of autophagy involved_in TAS
GO:0038061 Biological Process non-canonical NF-kappaB signal transduction involved_in IDA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IEP
GO:0045860 Biological Process positive regulation of protein kinase activity involved_in IBA
GO:0045860 Biological Process positive regulation of protein kinase activity involved_in IDA
GO:0032496 Biological Process response to lipopolysaccharide involved_in IDA
GO:0005737 Cellular Component cytoplasm is_active_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0010008 Cellular Component endosome membrane located_in TAS
GO:0005765 Cellular Component lysosomal membrane located_in IEA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005886 Cellular Component plasma membrane located_in TAS
Pathways
Name DB ID
Signaling by ERBB4 Reactome R-HSA-1236394
Nuclear signaling by ERBB4 Reactome R-HSA-1251985
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Adaptive Immune System Reactome R-HSA-1280218
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Reactome R-HSA-166058
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade Reactome R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade Reactome R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade Reactome R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade Reactome R-HSA-168188
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
NOD1/2 Signaling Pathway Reactome R-HSA-168638
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
Toll-like Receptor Cascades Reactome R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade Reactome R-HSA-181438
TCR signaling Reactome R-HSA-202403
Downstream TCR signaling Reactome R-HSA-202424
Fc epsilon receptor (FCERI) signaling Reactome R-HSA-2454202
FCERI mediated NF-kB activation Reactome R-HSA-2871837
TAK1-dependent IKK and NF-kappa-B activation Reactome R-HSA-445989
Interleukin-1 family signaling Reactome R-HSA-446652
Interleukin-17 signaling Reactome R-HSA-448424
Signaling by Interleukins Reactome R-HSA-449147
MAP kinase activation Reactome R-HSA-450294
activated TAK1 mediates p38 MAPK activation Reactome R-HSA-450302
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Reactome R-HSA-450321
TNFR1-induced NF-kappa-B signaling pathway Reactome R-HSA-5357956
CLEC7A (Dectin-1) signaling Reactome R-HSA-5607764
C-type lectin receptors (CLRs) Reactome R-HSA-5621481
Infectious disease Reactome R-HSA-5663205
Death Receptor Signaling Reactome R-HSA-73887
TNF signaling Reactome R-HSA-75893
Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
TICAM1,TRAF6-dependent induction of TAK1 complex Reactome R-HSA-9014325
Interleukin-1 signaling Reactome R-HSA-9020702
IRAK2 mediated activation of TAK1 complex Reactome R-HSA-937042
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
TRAF6-mediated induction of TAK1 complex within TLR4 complex Reactome R-HSA-937072
Alpha-protein kinase 1 signaling pathway Reactome R-HSA-9645460
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-2 Infection Reactome R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
SARS-CoV-2-host interactions Reactome R-HSA-9705683
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Reactome R-HSA-975163
MyD88 cascade initiated on plasma membrane Reactome R-HSA-975871
Viral Infection Pathways Reactome R-HSA-9824446
TLR4 signaling and tolerance (WP3851) WikiPathways WP3851_r121712
Measles virus infection (WP4630) WikiPathways WP4630_r123414
Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
IL-1 signaling pathway (WP195) WikiPathways WP195_r120702
miRNAs involvement in the immune response in sepsis (WP4329) WikiPathways WP4329_r123505
MAPK signaling pathway (WP382) WikiPathways WP382_r119087
Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
Interleukin-1 (IL-1) structural pathway (WP2637) WikiPathways WP2637_r117962
TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
RANKL/RANK signaling pathway (WP2018) WikiPathways WP2018_r120672
Exercise-induced circadian regulation (WP410) WikiPathways WP410_r117108
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_125861 2 miscRNA transcript variant 5 NC_000006 Reference
NM_001292035 3 mRNA transcript variant 4 NC_000006 Reference
NM_001369506 1 mRNA transcript variant 6 NC_000006 Reference
NM_001292034 3 mRNA transcript variant 3 NC_000006 Reference
NM_015093 6 mRNA transcript variant 1 NC_000006 Reference
XM_011535633 3 mRNA transcript variant X7 NC_000006 Reference
XM_047418487 1 mRNA transcript variant X3 NC_000006 Reference
XM_047418489 1 mRNA transcript variant X5 NC_000006 Reference
XM_047418486 1 mRNA transcript variant X2 NC_000006 Reference
XM_047418488 1 mRNA transcript variant X4 NC_000006 Reference
XM_017010592 3 mRNA transcript variant X6 NC_000006 Reference
XM_047418485 1 mRNA transcript variant X1 NC_000006 Reference
XM_047418490 1 mRNA transcript variant X8 NC_000006 Reference