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ATG4B

autophagy related 4B cysteine peptidase
General Information
Name autophagy related 4B cysteine peptidase
Alias
  • cysteine protease ATG4B
  • APG4 autophagy 4 homolog B
  • ATG4 autophagy related 4 homolog B
  • AUT-like 1 cysteine endopeptidase
  • autophagin-1
  • autophagy-related cysteine endopeptidase 1
  • autophagy-related protein 4 homolog B
  • hAPG4B
Gene_family Autophagy related
organism Homo sapiens
entrez_id 23192
location 2q37.3
transcript_count 8
exon_count 15
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Stringdb Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms
    nextProt Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:26378241, PubMed:29232556, PubMed:28821708, PubMed:30443548, PubMed:30661429, PubMed:22302004, PubMed:27527864, PubMed:28633005, PubMed:30076329). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:20818167, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28633005, PubMed:29458288, PubMed:30661429, PubMed:28287329). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989, PubMed:19322194). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:29458288, PubMed:32686895, PubMed:33909989, PubMed:19322194). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
ATG4B BioGRID CNPY3 GeneID BioGRID Proximity Label-MS
ATG4B BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID CCNF GeneID BioGRID Proximity Label-MS
ATG4B BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID PRKN GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID C9orf78 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID FAS GeneID BioGRID Proximity Label-MS
ATG4B BioGRID CCDC124 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID ZCCHC3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID NUFIP2 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID DCP1A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID COA4 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF3K GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID PABPC1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID GABARAPL1 GeneID BioGRID Affinity Capture-MS; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid
ATG4B BioGRID RPL13A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID PRRC2C GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RRP1B GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID NUP50 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID SMC2 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID NCAPD2 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID PSMD6 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL23 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID AIMP1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID USP10 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID H1-10 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID PABPC4 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF3J GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF3H GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF3B GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF3A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID STAM GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID TOP2A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID STAU1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID SRP54 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS26 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS25 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS23 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS19 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS16 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS15A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS15 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS13 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS12 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS9 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS8 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS7 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS5 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS4X GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS3A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPS3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPLP0 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL38 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL34 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL32 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL31 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL28 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL30 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL27 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL24 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL22 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL19 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL17 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL11 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL10 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL9 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL6 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RPL3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID KTN1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID ILF3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID GLUD1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF4E GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF4A1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID EIF2S3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID DHX9 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID KAT6A GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID MAP1LC3B2 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID MGME1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID FANK1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID GABARAPL2 GeneID BioGRID Affinity Capture-MS; Biochemical Activity; Reconstituted Complex; Two-hybrid
ATG4B BioGRID GABARAP GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
ATG4B BioGRID DDX3Y GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID STK16 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID KDM5C GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID GTF2F2 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID GTF2F1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID CSNK1E GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID CSNK1D GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
ATG4B BioGRID MAP1LC3C GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ATG4B BioGRID PRNP GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
ATG4B BioGRID ENG GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-MS; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid
ATG4B BioGRID SLC27A4 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
ATG4B BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID OGT GeneID BioGRID Affinity Capture-Western
ATG4B BioGRID RAB7B GeneID BioGRID Affinity Capture-Western
ATG4B BioGRID MYC GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID TES GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID SYNE3 GeneID BioGRID Two-hybrid
ATG4B BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
ATG4B BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
ATG4B BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
ATG4B BioGRID BAG3 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS
ATG4B BioGRID ATG8 GeneID BioGRID Two-hybrid
ATG4B BioGRID YWHAB GeneID BioGRID Co-fractionation
ATG4B BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
ATG4B BioGRID ATG10 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID ATG3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID AMBRA1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID CAMKK2 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID ATG12 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID ULK1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID STK3 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID KRT4 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID ANXA1 GeneID BioGRID Affinity Capture-MS
ATG4B BioGRID FBXW11 GeneID BioGRID Affinity Capture-MS
ATG4B Protein C14orf139 protein None HPRD
ATG4B Protein GABARAPL2 GeneID HPRD
ATG4B Protein MAP1LC3B GeneID HPRD
ATG4B Protein GABARAP GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
ATG4B LRRC29 0 0 0 163 1 1
ATG4B PRKAA1 0 0 253 396 1 2
ATG4B CHMP4B 0 0 104 324 1 2
ATG4B PPP2CA 0 0 0 199 1 1
ATG4B TP53INP2 0 0 170 169 1 2
ATG4B STX8 0 0 113 187 1 2
ATG4B FBXL4 0 0 0 163 1 1
ATG4B ABCG5 0 0 0 235 1 1
ATG4B TXN 0 0 113 150 1 1
ATG4B INF2 0 0 0 165 1 1
ATG4B CAPRIN1 0 0 0 208 1 1
ATG4B CHIT1 0 0 0 188 1 1
ATG4B TECPR1 0 0 216 501 1 1
ATG4B TUBA1A 0 0 0 217 1 1
ATG4B PITPNM2 0 0 0 150 1 1
ATG4B RHEB 0 0 166 277 1 2
ATG4B CHMP2A 0 0 55 305 1 1
ATG4B WDR45B 0 0 233 439 1 1
ATG4B COA8 0 0 0 162 1 1
ATG4B VCL 0 0 134 165 1 1
ATG4B RRS1 0 0 0 210 1 1
ATG4B IGBP1 0 0 0 206 1 1
ATG4B CAP1 0 0 0 232 1 1
ATG4B TUBB4B 0 0 0 240 1 1
ATG4B LIG4 0 0 0 226 1 1
ATG4B TECPR2 0 0 113 316 1 2
ATG4B NYAP1 0 0 0 286 1 1
ATG4B HTR2C 0 0 0 231 1 1
ATG4B VPS51 0 0 0 162 1 1
ATG4B CASP2 0 0 61 400 1 1
ATG4B RNF185 0 0 154 270 1 1
ATG4B RAB3GAP1 0 0 122 192 1 1
ATG4B WDR45 0 0 194 411 1 2
ATG4B ANAPC2 0 0 75 284 1 1
ATG4B IGF1 0 0 180 180 1 2
ATG4B WDFY3 0 0 283 373 1 2
ATG4B FNBP1L 0 0 124 571 1 1
ATG4B PLEKHA4 270 0 0 270 1 1
ATG4B ITSN2 0 0 0 155 1 1
ATG4B DUS1L 0 0 0 290 1 1
ATG4B ITM2B 0 0 56 163 1 1
ATG4B TGFBI 0 0 0 175 1 1
ATG4B PDE4B 0 0 0 183 1 1
ATG4B GOSR1 0 0 604 606 1 1
ATG4B GBAS 0 0 112 222 1 1
ATG4B ZNF408 0 0 0 265 1 1
ATG4B FBXO25 0 0 241 273 1 1
ATG4B UBA7 0 0 0 205 1 1
ATG4B TUBAL3 0 0 0 162 1 1
ATG4B CTSO 0 0 0 189 1 1
ATG4B PINK1 0 0 340 408 1 2
ATG4B UBQLN1 0 0 138 275 1 1
ATG4B PPP3CA 0 0 0 266 1 1
ATG4B PDE5A 0 0 0 165 1 1
ATG4B EIF4EBP1 0 0 150 169 1 2
ATG4B PEX6 0 0 0 182 1 1
ATG4B NLRC4 0 0 166 182 1 2
ATG4B PARL 0 0 107 178 1 1
ATG4B VMP1 0 0 294 477 1 2
ATG4B TMEM74 0 0 261 285 1 2
ATG4B FBXL14 0 0 0 163 1 1
ATG4B NOX4 0 0 125 157 1 2
ATG4B WBP11 0 0 96 192 1 1
ATG4B CPT1A 0 0 61 263 1 1
ATG4B CTDP1 0 0 0 247 1 1
ATG4B RAB7B 270 0 425 629 1 1
ATG4B KBTBD6 0 0 183 234 1 1
ATG4B VDAC1 0 0 143 187 1 2
ATG4B VAMP7 0 0 134 242 1 2
ATG4B PITPNB 0 0 0 150 1 1
ATG4B FBXL22 0 0 0 163 1 1
ATG4B FAM155A 0 0 0 230 1 1
ATG4B MRPS2 0 0 0 160 1 1
ATG4B TBK1 0 0 213 259 1 2
ATG4B ATG2B 0 0 427 727 1 2
ATG4B TUBB2A 0 0 0 362 1 1
ATG4B LRCH2 0 0 0 151 1 1
ATG4B RGS19 0 0 181 251 1 2
ATG4B RAB11A 0 0 117 177 1 2
ATG4B XPNPEP3 0 0 0 211 1 1
ATG4B BNIP1 0 0 194 211 1 2
ATG4B ATG3 278 0 883 985 1 2
ATG4B ENSG00000250232 0 0 117 355 1 1
ATG4B FOXO3 0 0 405 420 1 2
ATG4B CNNM3 0 0 0 194 1 1
ATG4B ATP6V1C1 0 0 136 190 1 1
ATG4B FBXL7 0 0 0 163 1 1
ATG4B FAM204A 0 0 203 203 1 1
ATG4B PDE6C 0 0 0 165 1 1
ATG4B CUL3 0 0 112 318 1 2
ATG4B PI4K2A 0 0 103 161 1 1
ATG4B STAMBPL1 0 0 0 185 1 1
ATG4B TUBE1 0 0 0 190 1 1
ATG4B ATG4D 0 0 684 211 1 2
ATG4B FCHSD1 0 0 0 186 1 1
ATG4B PITPNM3 0 0 0 150 1 1
ATG4B DBI 0 0 145 244 1 1
ATG4B PLEKHM1 0 0 295 319 1 1
ATG4B PSMC4 0 0 108 217 1 1
ATG4B FGF22 0 0 66 164 1 1
ATG4B ATG12 220 0 808 949 1 2
ATG4B PEA15 0 0 126 179 1 1
ATG4B TLR2 0 0 142 160 1 2
ATG4B LRRK2 0 0 123 204 1 2
ATG4B STK38L 0 0 0 437 1 1
ATG4B ADCY10 0 0 0 241 1 1
ATG4B SUFU 0 0 0 303 1 1
ATG4B SNAPIN 0 0 123 196 1 1
ATG4B SPC25 0 0 120 360 1 1
ATG4B ANKRD40 0 0 154 196 1 1
ATG4B FOXO1 0 0 261 327 1 2
ATG4B SLC44A5 0 0 0 172 1 1
ATG4B PDE7B 0 0 0 165 1 1
ATG4B PDE6A 0 0 0 165 1 1
ATG4B DNM1 0 0 0 171 1 1
ATG4B HSPA5 0 0 108 201 1 2
ATG4B CNNM4 0 0 0 194 1 1
ATG4B TFE3 0 0 101 185 1 2
ATG4B SNX2 0 0 0 186 1 1
ATG4B SEC61B 0 0 113 174 1 1
ATG4B SEC22B 0 0 81 283 1 1
ATG4B RLBP1 0 0 56 162 1 1
ATG4B RANBP1 0 0 95 151 1 1
ATG4B ATG10 314 0 681 853 1 2
ATG4B WDFY4 0 0 0 162 1 1
ATG4B ATG5 0 0 759 895 1 2
ATG4B KSR1 270 0 0 287 1 1
ATG4B NIPSNAP1 0 0 122 229 1 1
ATG4B DUS3L 0 0 0 264 1 1
ATG4B FAM179A 0 0 0 185 1 1
ATG4B XBP1 0 0 184 185 1 2
ATG4B TP63 0 0 72 167 1 2
ATG4B HIPK2 0 0 45 166 1 2
ATG4B UFM1 0 0 113 150 1 1
ATG4B CTSB 0 0 323 359 1 2
ATG4B SIRT1 0 0 243 295 1 2
ATG4B TUBB 0 0 0 222 1 1
ATG4B MAP3K5 0 0 81 178 1 1
ATG4B HMGB1 0 0 191 208 1 2
ATG4B CTSK 0 0 150 236 1 2
ATG4B PDIK1L 0 0 0 471 1 1
ATG4B ATAD2B 0 0 0 152 1 1
ATG4B ONECUT2 0 0 0 165 1 1
ATG4B ENSG00000258947 0 0 0 220 1 1
ATG4B MAPK14 0 0 119 154 1 2
ATG4B GABARAP 626 900 869 999 1 2
ATG4B SOGA1 0 0 123 216 1 1
ATG4B PTEN 0 0 211 284 1 2
ATG4B RHBDD1 0 0 0 343 1 1
ATG4B PI4KB 0 0 69 191 1 1
ATG4B DNM1L 0 0 73 209 1 2
ATG4B WIPI1 0 0 562 819 1 2
ATG4B KIAA0226 0 0 310 344 1 1
ATG4B PRKAA2 0 0 225 373 1 2
ATG4B ATG7 0 0 839 943 1 2
ATG4B SLC44A1 0 0 0 172 1 1
ATG4B FMN1 0 0 0 560 1 1
ATG4B LRCH3 0 0 0 151 1 1
ATG4B ZNF821 0 0 0 152 1 1
ATG4B NICN1 0 0 150 170 1 1
ATG4B CTSD 0 0 342 396 1 2
ATG4B TRIM63 0 0 236 254 1 1
ATG4B VTI1B 0 0 606 621 1 2
ATG4B CTSA 0 0 88 280 1 1
ATG4B LMF1 0 0 0 183 1 1
ATG4B MAP1A 0 0 422 539 1 2
ATG4B STK36 0 0 120 172 1 1
ATG4B BCAS3 0 0 0 287 1 1
ATG4B SLC26A11 0 0 123 194 1 1
ATG4B LAMP1 0 0 403 494 1 2
ATG4B NEDD8 0 0 117 167 1 2
ATG4B CFLAR 0 0 89 190 1 2
ATG4B EGFR 0 0 134 224 1 2
ATG4B HTT 0 0 194 277 1 2
ATG4B TP53 0 0 268 268 1 2
ATG4B IRGQ 0 0 0 392 1 1
ATG4B TGM2 0 0 113 209 1 2
ATG4B CNNM2 0 0 0 194 1 1
ATG4B EIF2AK4 0 0 112 173 1 2
ATG4B CPVL 0 0 0 205 1 1
ATG4B CD300C 0 0 502 502 1 1
ATG4B NDUFS1 0 0 0 158 1 1
ATG4B CISD2 0 0 218 224 1 2
ATG4B C7orf25 0 0 157 156 1 1
ATG4B VAMP8 0 0 164 193 1 2
ATG4B FBXL15 0 0 0 163 1 1
ATG4B HDAC6 0 0 232 257 1 2
ATG4B CASC5 0 0 0 179 1 1
ATG4B TUBA3D 0 0 0 212 1 1
ATG4B ACP5 0 0 83 226 1 1
ATG4B ENSG00000261832 0 0 120 184 1 1
ATG4B DVL1 0 0 0 179 1 1
ATG4B AMN1 0 0 0 163 1 1
ATG4B PPARGC1A 0 0 174 173 1 2
ATG4B PCK1 0 0 0 300 1 1
ATG4B UBE2H 0 0 0 246 1 1
ATG4B TM9SF1 0 0 260 334 1 2
ATG4B LGMN 0 0 0 156 1 1
ATG4B PARK2 0 0 269 302 1 1
ATG4B STK11 0 0 182 277 1 2
ATG4B KRT4 154 0 0 153 1 1
ATG4B BOLA2 0 0 181 256 1 1
ATG4B RB1CC1 0 0 604 768 1 2
ATG4B ACTA1 0 0 174 192 1 1
ATG4B FBXL16 0 0 0 163 1 1
ATG4B SRGAP2 0 0 0 193 1 1
ATG4B TBCB 0 0 76 159 1 1
ATG4B FBXO24 0 0 0 312 1 1
ATG4B SIRT2 0 0 134 190 1 2
ATG4B GRID2IP 0 0 0 160 1 1
ATG4B MAP1LC3B2 0 0 247 601 1 1
ATG4B TMBIM4 0 0 0 183 1 1
ATG4B GAPDH 0 0 268 271 1 2
ATG4B FCHSD2 0 0 0 186 1 1
ATG4B RAB33B 0 0 194 364 1 2
ATG4B FYCO1 0 0 294 320 1 2
ATG4B ARHGAP4 0 0 0 186 1 1
ATG4B KIF3B 0 0 53 174 1 1
ATG4B POLH 0 0 0 158 1 1
ATG4B DNM3 0 0 0 171 1 1
ATG4B HRAS 0 0 126 184 1 2
ATG4B MFN2 0 0 170 252 1 2
ATG4B UBE2G1 0 0 0 197 1 1
ATG4B CTSL 0 0 262 302 1 2
ATG4B BAG3 270 0 134 454 1 2
ATG4B POSTN 0 0 0 175 1 1
ATG4B NEDD4 0 0 140 241 1 2
ATG4B FBXL12 0 0 0 163 1 1
ATG4B RAB5A 0 0 255 323 1 2
ATG4B NUDT22 0 0 180 179 1 1
ATG4B SCPEP1 0 0 0 210 1 1
ATG4B SLC44A3 0 0 0 172 1 1
ATG4B CLK3 0 0 0 171 1 1
ATG4B ACAN 0 0 0 165 1 1
ATG4B PIK3C3 0 0 681 853 1 2
ATG4B PIRT 0 0 170 169 1 1
ATG4B MTOR 0 0 465 509 1 2
ATG4B FLAD1 0 0 0 189 1 1
ATG4B CARS 0 0 0 415 1 1
ATG4B TRAPPC8 0 0 97 151 1 1
ATG4B TMEM184C 0 0 0 164 1 1
ATG4B MAN2C1 0 0 0 265 1 1
ATG4B ZNF740 0 0 0 163 1 1
ATG4B SNX8 0 0 0 186 1 1
ATG4B ATG9A 0 0 566 816 1 2
ATG4B VPS16 0 0 167 202 1 1
ATG4B PLEKHF2 0 0 113 227 1 1
ATG4B MUL1 0 0 131 158 1 2
ATG4B ASS1 0 0 0 188 1 1
ATG4B HSP90AA1 0 0 142 189 1 2
ATG4B PCK2 0 0 0 198 1 1
ATG4B SQSTM1 270 0 720 814 1 2
ATG4B BNIP3 0 0 519 572 1 2
ATG4B UTP15 0 0 0 188 1 1
ATG4B STK38 0 0 0 437 1 1
ATG4B ABCG1 0 0 0 235 1 2
ATG4B GBP7 0 0 795 808 1 1
ATG4B TES 270 0 0 315 1 1
ATG4B NLRX1 0 0 103 169 1 2
ATG4B ATG13 0 0 610 780 1 2
ATG4B PHF12 0 0 0 160 1 1
ATG4B PIK3CG 0 0 141 234 1 1
ATG4B GPSM2 0 0 180 205 1 1
ATG4B YKT6 0 0 0 155 1 1
ATG4B DAPK1 0 0 218 251 1 2
ATG4B UBA6 0 0 0 228 1 1
ATG4B BSN 0 0 0 165 1 2
ATG4B NCOA4 0 0 157 222 1 2
ATG4B UBXN8 0 0 0 173 1 1
ATG4B NFKBIE 0 0 0 176 1 1
ATG4B CTSF 0 0 654 690 1 1
ATG4B ALG6 0 0 0 206 1 1
ATG4B PRKACB 0 0 0 209 1 1
ATG4B SLC44A2 0 0 0 172 1 1
ATG4B WBSCR16 0 0 0 169 1 1
ATG4B EIF2AK2 0 0 81 238 1 2
ATG4B MFN1 0 0 82 173 1 2
ATG4B ATP6V0D2 0 0 66 166 1 1
ATG4B PLD1 0 0 49 249 1 2
ATG4B PTK2 0 0 135 154 1 2
ATG4B MAPK8 0 0 193 213 1 2
ATG4B COL4A1 0 0 0 208 1 1
ATG4B MAP1S 0 0 220 268 1 2
ATG4B PPP2CB 0 0 0 199 1 1
ATG4B TUFM 0 0 81 150 1 2
ATG4B KDM2A 0 0 0 163 1 1
ATG4B PSMD11 0 0 83 169 1 1
ATG4B SESN2 0 0 143 174 1 2
ATG4B PDE6B 0 0 0 165 1 1
ATG4B DNPEP 0 0 0 228 1 1
ATG4B ENDOU 0 0 58 274 1 1
ATG4B TUBD1 0 0 0 165 1 1
ATG4B TSR2 0 0 0 345 1 1
ATG4B PITPNC1 0 0 0 150 1 1
ATG4B CTSH 0 0 54 172 1 1
ATG4B LPIN3 0 0 46 228 1 1
ATG4B DICER1 0 0 0 210 1 1
ATG4B SH3GLB1 0 0 321 321 1 2
ATG4B TMEM207 0 0 180 179 1 1
ATG4B PCSK1 0 0 57 160 1 1
ATG4B BFAR 0 0 113 223 1 1
ATG4B TRAF6 0 0 210 236 1 2
ATG4B FNBP1 0 0 0 438 1 1
ATG4B CYCS 0 0 150 165 1 2
ATG4B CAMKK1 0 0 0 200 1 1
ATG4B ONECUT1 0 0 0 204 1 1
ATG4B GGH 0 0 108 200 1 1
ATG4B DRAM2 0 0 243 244 1 2
ATG4B STK35 0 0 0 471 1 1
ATG4B LGALS8 0 0 218 218 1 1
ATG4B CASP7 0 0 90 261 1 1
ATG4B PITPNM1 0 0 0 150 1 1
ATG4B ALB 0 0 167 179 1 2
ATG4B GBP1 0 0 178 215 1 1
ATG4B MAP1B 0 0 233 313 1 2
ATG4B PAX6 0 0 0 160 1 1
ATG4B ATG16L2 0 0 468 595 1 2
ATG4B PDE4A 0 0 0 183 1 1
ATG4B NUP35 0 0 69 176 1 1
ATG4B CAP2 0 0 0 237 1 1
ATG4B SIRT6 0 0 143 233 1 2
ATG4B SGK494 0 0 0 227 1 1
ATG4B PDE4D 0 0 0 183 1 1
ATG4B DVL2 0 0 0 196 1 2
ATG4B PAXIP1 0 0 0 188 1 1
ATG4B EPG5 0 0 205 499 1 2
ATG4B ABCG2 0 0 0 235 1 1
ATG4B ULK3 0 0 155 687 1 2
ATG4B STBD1 0 0 133 162 1 1
ATG4B FAM179B 0 0 0 185 1 1
ATG4B RPS6KB1 0 0 260 316 1 2
ATG4B IRS1 0 0 103 196 1 2
ATG4B TRMT2A 0 0 0 237 1 1
ATG4B SESN1 0 0 157 157 1 1
ATG4B GUCY2F 0 0 0 161 1 1
ATG4B DDI2 0 0 0 152 1 1
ATG4B FAF2 0 0 0 227 1 1
ATG4B ATG2A 0 0 459 746 1 2
ATG4B CANX 0 0 140 160 1 2
ATG4B KLC2 0 0 0 182 1 1
ATG4B SLC27A4 270 0 419 567 1 1
ATG4B CAT 0 0 150 203 1 2
ATG4B BAK1 0 0 161 204 1 2
ATG4B ANKRD10 0 0 0 348 1 1
ATG4B PITPNA 0 0 0 180 1 1
ATG4B ITSN1 0 0 0 150 1 1
ATG4B DDIT4 0 0 260 260 1 2
ATG4B WIPI2 0 0 519 809 1 2
ATG4B FIS1 0 0 123 273 1 2
ATG4B VPS11 0 0 134 233 1 1
ATG4B RSC1A1 0 0 0 152 1 1
ATG4B NFYC 0 0 0 163 1 1
ATG4B TNF 0 0 180 179 1 2
ATG4B NBR1 0 0 520 636 1 2
ATG4B LPIN2 0 0 0 224 1 1
ATG4B CHIA 0 0 0 188 1 1
ATG4B CCPG1 0 0 154 153 1 1
ATG4B TLDC2 0 0 0 257 1 1
ATG4B UVRAG 0 0 563 753 1 2
ATG4B DOCK6 0 0 0 154 1 1
ATG4B TXNIP 0 0 260 276 1 2
ATG4B ENSG00000267157 0 0 0 228 1 1
ATG4B RAB7A 0 0 455 640 1 2
ATG4B DRAM1 0 0 414 454 1 2
ATG4B SNX7 0 0 0 367 1 1
ATG4B SRGAP3 0 0 0 186 1 1
ATG4B ENSA 0 0 82 159 1 1
ATG4B FBXL17 0 0 0 205 1 1
ATG4B ERBB2 0 0 134 300 1 2
ATG4B VPS37A 0 0 0 238 1 1
ATG4B SIRT4 0 0 134 218 1 1
ATG4B FEM1A 0 0 0 167 1 1
ATG4B LRCH1 0 0 0 185 1 1
ATG4B ATF6 0 0 203 203 1 2
ATG4B CARS2 0 0 0 306 1 1
ATG4B ABCG8 0 0 0 235 1 1
ATG4B AKT1 0 0 358 428 1 2
ATG4B GBP2 0 0 150 188 1 1
ATG4B C2orf27A 0 0 218 218 1 1
ATG4B ENSG00000260272 0 0 0 214 1 1
ATG4B ATF4 0 0 152 157 1 2
ATG4B TUBA3C 0 0 0 212 1 1
ATG4B UBA5 0 0 48 263 1 1
ATG4B HECTD1 0 0 134 181 1 1
ATG4B TSC2 0 0 213 336 1 2
ATG4B BNIP3L 0 0 468 488 1 2
ATG4B STK3 300 0 0 370 1 1
ATG4B CDKN1B 0 0 124 161 1 2
ATG4B WDR83 0 0 0 166 1 1
ATG4B CAMK1G 0 0 55 164 1 1
ATG4B ZFYVE1 0 0 379 498 1 2
ATG4B PDE9A 0 0 0 165 1 1
ATG4B FBXL6 0 0 0 188 1 1
ATG4B FBXL13 0 0 0 163 1 1
ATG4B EIF2S1 0 0 125 154 1 2
ATG4B OXR1 0 0 0 291 1 1
ATG4B STX17 0 0 392 510 1 2
ATG4B UBA3 0 0 82 239 1 1
ATG4B TUBB8 0 0 0 233 1 1
ATG4B RABGEF1 0 0 0 183 1 1
ATG4B PLSCR1 0 0 95 161 1 1
ATG4B LGALS3 0 0 120 160 1 2
ATG4B ACLY 0 0 47 531 1 1
ATG4B TUBB8B 0 0 0 218 1 1
ATG4B EIF2AK3 0 0 220 233 1 2
ATG4B STK25 0 0 81 152 1 1
ATG4B YWHAB 271 0 0 310 1 1
ATG4B PCSK9 0 0 44 186 1 1
ATG4B CUX2 0 0 0 171 1 1
ATG4B USP2 0 0 53 155 1 1
ATG4B EEA1 0 0 217 243 1 2
ATG4B TUBA1C 0 0 53 245 1 1
ATG4B ATG4C 0 0 707 226 1 2
ATG4B STAMBP 0 0 0 203 1 1
ATG4B CDC34 0 0 0 293 1 1
ATG4B TUBG1 0 0 0 166 1 1
ATG4B LRCH4 0 0 0 275 1 1
ATG4B TUBA8 0 0 0 162 1 1
ATG4B MORF4L1 0 0 0 158 1 1
ATG4B SCRIB 0 0 0 155 1 1
ATG4B NOD2 0 0 231 247 1 2
ATG4B FBXO39 0 0 0 163 1 1
ATG4B ATG16L1 0 0 710 858 1 2
ATG4B NYAP2 0 0 0 378 1 1
ATG4B TUBB6 0 0 0 190 1 1
ATG4B CASP3 0 0 314 338 1 2
ATG4B TUBB2B 0 0 0 269 1 1
ATG4B SMURF1 0 0 166 248 1 1
ATG4B DUS4L 0 0 0 270 1 1
ATG4B NLRP3 0 0 213 219 1 2
ATG4B KLC1 0 0 0 151 1 1
ATG4B ATG101 0 0 561 745 1 2
ATG4B CYBB 0 0 396 469 1 2
ATG4B UBA2 0 0 46 339 1 1
ATG4B CTSS 0 0 159 216 1 1
ATG4B UFSP2 0 0 211 211 1 1
ATG4B TRIP10 0 0 0 259 1 1
ATG4B ATXN3 0 0 92 150 1 2
ATG4B BECN1 0 0 739 914 1 2
ATG4B FBXL19 0 0 0 184 1 1
ATG4B ANXA1 308 0 0 307 1 1
ATG4B SCAMP5 0 0 90 182 1 1
ATG4B SNX4 0 0 67 208 1 2
ATG4B RBBP8 0 0 0 208 1 1
ATG4B LPIN1 0 0 81 256 1 2
ATG4B TUBG2 0 0 0 166 1 1
ATG4B ACADVL 0 0 0 284 1 1
ATG4B SEC62 0 0 87 175 1 1
ATG4B DEPTOR 0 0 194 202 1 2
ATG4B UFSP1 0 0 166 165 1 1
ATG4B FAF1 0 0 0 191 1 1
ATG4B WDR59 0 0 0 166 1 1
ATG4B ONECUT3 0 0 0 165 1 1
ATG4B KRAS 0 0 113 189 1 2
ATG4B TMEM218 0 0 149 167 1 1
ATG4B JMJD6 0 0 0 196 1 1
ATG4B C18orf8 0 0 137 155 1 1
ATG4B TBC1D25 0 0 158 246 1 1
ATG4B KDM2B 0 0 0 163 1 1
ATG4B MLST8 0 0 139 313 1 1
ATG4B ULK1 341 0 623 904 1 2
ATG4B TSG101 0 0 72 183 1 2
ATG4B NCF2 0 0 103 508 1 1
ATG4B MAP1LC3B 972 900 919 999 1 2
ATG4B AGFG1 0 0 112 269 1 1
ATG4B WDR11 0 0 0 362 1 1
ATG4B SLC24A5 0 0 0 356 1 1
ATG4B CALCOCO2 0 0 469 472 1 2
ATG4B MIB1 0 0 0 226 1 1
ATG4B ENSG00000100926 0 0 260 335 1 1
ATG4B OPTN 0 0 391 408 1 2
ATG4B PIM2 0 0 81 190 1 1
ATG4B PDE10A 0 0 0 165 1 1
ATG4B AMBRA1 129 0 560 618 1 2
ATG4B GOPC 0 0 106 200 1 2
ATG4B MAEA 0 0 0 256 1 1
ATG4B UQCR10 0 0 0 199 1 1
ATG4B SNX30 0 0 0 367 1 1
ATG4B UBE2S 0 0 306 367 1 1
ATG4B GUCY2D 0 0 0 161 1 1
ATG4B OGT 270 0 0 286 1 2
ATG4B TRIM54 0 0 140 186 1 1
ATG4B ENG 270 0 0 270 1 2
ATG4B CNNM1 0 0 0 194 1 1
ATG4B PRKACG 0 0 0 209 1 1
ATG4B PRKX 0 0 0 209 1 1
ATG4B FADD 0 0 147 173 1 2
ATG4B TUBA4A 0 0 579 656 1 1
ATG4B DDX54 0 0 101 160 1 1
ATG4B STAT3 0 0 136 157 1 2
ATG4B RAB9A 0 0 0 188 1 2
ATG4B SNX12 0 0 0 162 1 1
ATG4B GMPPA 0 0 0 176 1 1
ATG4B ERN1 0 0 180 215 1 2
ATG4B CAMKK2 65 0 137 298 1 2
ATG4B CYBA 0 0 122 645 1 1
ATG4B HGS 0 0 97 212 1 2
ATG4B THAP4 0 0 181 237 1 1
ATG4B HOOK3 0 0 0 325 1 1
ATG4B SETD8 0 0 0 231 1 1
ATG4B RNF126 0 0 0 182 1 1
ATG4B MX1 0 0 66 170 1 1
ATG4B PPP3CB 0 0 0 266 1 1
ATG4B TUBA3E 0 0 0 212 1 1
ATG4B NPC1 0 0 109 174 1 2
ATG4B FANK1 476 0 0 490 1 1
ATG4B TBC1D24 0 0 0 218 1 1
ATG4B IRGM 0 0 417 416 1 2
ATG4B MYC 66 0 161 241 1 2
ATG4B EHMT2 0 0 122 155 1 2
ATG4B NCOA7 0 0 0 425 1 1
ATG4B ACAD9 0 0 0 168 1 1
ATG4B RNF214 0 0 0 386 1 1
ATG4B ENSG00000272772 0 0 0 172 1 1
ATG4B UBE2K 0 0 351 413 1 1
ATG4B TAX1BP1 0 0 149 171 1 2
ATG4B FBXL3 0 0 0 163 1 1
ATG4B PPP3CC 0 0 0 266 1 1
ATG4B UBA1 0 0 58 219 1 1
ATG4B USP43 0 0 0 161 1 1
ATG4B ANXA5 0 0 150 168 1 2
ATG4B PDE11A 0 0 0 165 1 1
ATG4B PDE4C 0 0 0 174 1 1
ATG4B FBXO32 0 0 292 292 1 2
ATG4B TUBB1 0 0 0 190 1 1
ATG4B IFNG 0 0 90 226 1 2
ATG4B SLC22A4 0 0 0 150 1 1
ATG4B PRKACA 0 0 0 209 1 1
ATG4B LRSAM1 0 0 195 233 1 2
ATG4B ARF1 0 0 134 196 1 1
ATG4B PHRF1 0 0 0 187 1 1
ATG4B GABARAPL2 677 900 864 998 1 2
ATG4B CDK10 0 0 0 155 1 1
ATG4B ATG14 0 0 657 789 1 2
ATG4B AGFG2 0 0 0 271 1 1
ATG4B BCL2L1 0 0 262 292 1 2
ATG4B ANAPC5 0 0 60 287 1 1
ATG4B TUBB4A 0 0 0 218 1 1
ATG4B PIK3R4 0 0 518 775 1 2
ATG4B LONRF2 0 0 0 175 1 1
ATG4B FGGY 0 0 0 260 1 1
ATG4B TMEM184A 0 0 0 242 1 1
ATG4B SRGAP2C 0 0 0 186 1 1
ATG4B MAP1LC3A 874 900 764 999 1 2
ATG4B PDE7A 0 0 0 165 1 1
ATG4B UBE2R2 0 0 0 364 1 1
ATG4B CLN3 0 0 126 190 1 2
ATG4B HIF1A 0 0 170 188 1 2
ATG4B SIRT5 0 0 139 204 1 1
ATG4B GLT1D1 0 0 151 150 1 1
ATG4B NAE1 0 0 0 205 1 1
ATG4B IL1B 0 0 217 217 1 2
ATG4B DOCK7 0 0 0 154 1 1
ATG4B CCNF 0 0 43 151 1 1
ATG4B FRAT2 0 0 0 259 1 1
ATG4B GPR37 0 0 52 217 1 1
ATG4B IL6 0 0 164 163 1 2
ATG4B MTMR3 0 0 229 363 1 2
ATG4B CCNC 0 0 43 176 1 1
ATG4B MAST1 0 0 0 249 1 1
ATG4B TMEM184B 0 0 0 258 1 1
ATG4B GUCY1A3 0 0 54 160 1 1
ATG4B HSPA8 0 0 193 243 1 2
ATG4B EIF4G1 0 0 82 168 1 2
ATG4B RAB24 0 0 391 447 1 2
ATG4B ABCG4 0 0 0 235 1 1
ATG4B GABARAPL1 793 900 926 999 1 2
ATG4B TUBA1B 0 0 0 216 1 1
ATG4B SIRT7 0 0 113 171 1 2
ATG4B PROSC 0 0 0 156 1 1
ATG4B STK4 0 0 73 201 1 1
ATG4B SLC44A4 0 0 0 172 1 1
ATG4B TFEB 0 0 401 418 1 2
ATG4B RNF5 0 0 460 491 1 1
ATG4B KEAP1 0 0 181 246 1 2
ATG4B SIRT3 0 0 134 197 1 2
ATG4B INS 0 0 181 181 1 2
ATG4B ACTB 0 0 320 334 1 2
ATG4B MST4 0 0 321 365 1 1
ATG4B MAP2K3 0 0 48 169 1 1
ATG4B ULK2 0 0 610 852 1 2
ATG4B SNCA 0 0 166 169 1 2
ATG4B SNAP29 0 0 243 335 1 2
ATG4B MOCS3 0 0 0 205 1 1
ATG4B CASP1 0 0 235 262 1 2
ATG4B TEX264 0 0 213 219 1 1
ATG4B UBE3C 0 0 0 158 1 1
ATG4B TMEM173 0 0 76 179 1 1
ATG4B DVL3 0 0 0 154 1 1
ATG4B SNX1 0 0 0 186 1 1
ATG4B MIB2 0 0 0 246 1 1
ATG4B RBM33 0 0 0 190 1 1
ATG4B GRN 0 0 81 184 1 1
ATG4B GOLGA2 0 0 150 169 1 1
ATG4B LAMP2 0 0 344 397 1 2
ATG4B ACAP1 0 0 0 207 1 1
ATG4B NEMF 0 0 0 351 1 1
ATG4B CAPN2 0 0 194 236 1 2
ATG4B ATF7IP 0 0 180 179 1 1
ATG4B EI24 0 0 67 183 1 2
ATG4B SRGAP2B 0 0 0 186 1 1
ATG4B FUNDC1 0 0 283 282 1 2
ATG4B SAE1 0 0 0 208 1 1
ATG4B TGIF2-C20orf24 0 0 0 265 1 1
ATG4B USP36 0 0 113 346 1 1
ATG4B E4F1 0 0 0 175 1 1
ATG4B ACAP2 0 0 0 212 1 1
ATG4B GNPTAB 0 0 0 189 1 1
ATG4B USP24 0 0 0 259 1 1
ATG4B VANGL2 0 0 0 185 1 1
ATG4B TRAPPC11 0 0 66 279 1 1
ATG4B GRINA 0 0 0 160 1 1
ATG4B CPT1B 0 0 46 305 1 1
ATG4B ACAP3 0 0 0 245 1 1
ATG4B VPS18 0 0 156 240 1 1
ATG4B TBC1D5 0 0 160 190 1 2
ATG4B ZUFSP 0 0 125 235 1 1
ATG4B RPTOR 0 0 212 278 1 2
ATG4B PSMD4 0 0 108 165 1 1
ATG4B SRGAP1 0 0 0 186 1 1
ATG4B STK16 229 0 0 228 1 1
ATG4B PDE2A 0 0 0 165 1 1
ATG4B ATPAF2 0 0 0 449 1 1
ATG4B RAB8B 0 0 124 151 1 2
ATG4B CASP9 0 0 140 181 1 2
ATG4B ITPR1 0 0 122 156 1 2
ATG4B DUS2 0 0 0 308 1 1
ATG4B TBC1D15 0 0 64 165 1 1
ATG4B FAM155B 0 0 0 230 1 1
ATG4B TUBB3 0 0 43 226 1 1
ATG4B CHRAC1 0 0 0 163 1 1
ATG4B ANKRD46 0 0 0 413 1 1
ATG4B SNPH 0 0 94 156 1 1
ATG4B ZMIZ2 0 0 120 165 1 1
ATG4B CASP8 0 0 183 221 1 2
ATG4B MAP1LC3C 488 900 814 994 1 2
ATG4B CUX1 0 0 0 171 1 1
ATG4B DNM2 0 0 0 189 1 1
ATG4B BOLA2B 0 0 97 172 1 1
ATG4B FICD 0 0 0 188 1 1
ATG4B RAB3GAP2 0 0 107 184 1 1
ATG4B RAB9B 0 0 0 188 1 1
ATG4B DDX58 0 0 142 174 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004197 Molecular Function cysteine-type endopeptidase activity enables IDA
GO:0004197 Molecular Function cysteine-type endopeptidase activity enables TAS
GO:0008234 Molecular Function cysteine-type peptidase activity enables IDA
GO:0004175 Molecular Function endopeptidase activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0019786 Molecular Function protein-phosphatidylethanolamide deconjugating activity enables IDA
GO:0097110 Molecular Function scaffold protein binding enables IPI
GO:0000045 Biological Process autophagosome assembly involved_in IDA
GO:0006914 Biological Process autophagy involved_in IDA
GO:0016236 Biological Process macroautophagy involved_in TAS
GO:0016237 Biological Process microautophagy involved_in IDA
GO:0000423 Biological Process mitophagy involved_in IMP
GO:0031173 Biological Process otolith mineralization completed early in development involved_in ISS
GO:0051697 Biological Process protein delipidation acts_upstream_of_or_within IDA
GO:0051697 Biological Process protein delipidation involved_in IDA
GO:0034497 Biological Process protein localization to phagophore assembly site involved_in IMP
GO:0015031 Biological Process protein transport involved_in IEA
GO:0006508 Biological Process proteolysis involved_in IDA
GO:0000421 Cellular Component autophagosome membrane is_active_in IDA
GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005783 Cellular Component endoplasmic reticulum located_in IEA
GO:0005739 Cellular Component mitochondrion located_in IEA
Pathways
Name DB ID
Macroautophagy Reactome R-HSA-1632852
Autophagy Reactome R-HSA-9612973
2q37 copy number variation syndrome (WP5224) WikiPathways WP5224_r122740
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_005246992 5 mRNA transcript variant X1 NC_000002 Reference
NM_178326 3 mRNA transcript variant 2 NC_000002 Reference
NM_013325 5 mRNA transcript variant 1 NC_000002 Reference
XM_047443738 1 mRNA transcript variant X2 NC_000002 Reference
XM_047443739 1 mRNA transcript variant X3 NC_000002 Reference
XM_047443741 1 mRNA transcript variant X5 NC_000002 Reference
XM_047443742 1 mRNA transcript variant X6 NC_000002 Reference
XM_047443740 1 mRNA transcript variant X4 NC_000002 Reference