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ARC

activity regulated cytoskeleton associated protein
General Information
Name activity regulated cytoskeleton associated protein
Alias
  • activity-regulated cytoskeleton-associated protein
  • ARC/ARG3.1
  • activity-regulated gene 3.1 protein homolog
Gene_family Gag like LTR retrotransposon derived genes
organism Homo sapiens
entrez_id 23237
location 8q24.3
transcript_count 2
exon_count 2
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Predicted to enable mRNA binding activity. Involved in cell migration; cytoskeleton organization; and regulation of cell morphogenesis. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration; Gag like LTR retrotransposon derived genes
    nextProt Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
ARC BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
ARC BioGRID EGFR GeneID BioGRID Proximity Label-MS
ARC BioGRID INSYN1 GeneID BioGRID Affinity Capture-MS
ARC BioGRID FAM83B GeneID BioGRID Affinity Capture-MS
ARC BioGRID PIP4P2 GeneID BioGRID Affinity Capture-MS
ARC BioGRID NDE1 GeneID BioGRID Affinity Capture-MS
ARC BioGRID RIN2 GeneID BioGRID Affinity Capture-MS
ARC BioGRID STUB1 GeneID BioGRID Affinity Capture-Western
ARC BioGRID ITPRID2 GeneID BioGRID Affinity Capture-MS
ARC BioGRID GSK3B GeneID BioGRID Affinity Capture-Western
ARC BioGRID FER GeneID BioGRID Affinity Capture-MS
ARC BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
ARC BioGRID KRAS GeneID BioGRID Proximity Label-MS
ARC BioGRID RET GeneID BioGRID Proximity Label-MS
ARC BioGRID SH2D4A GeneID BioGRID Two-hybrid
ARC BioGRID TBX18 GeneID BioGRID Two-hybrid
ARC BioGRID S100P GeneID BioGRID Two-hybrid
ARC BioGRID CSRP2 GeneID BioGRID Two-hybrid
ARC BioGRID SPTBN4 GeneID BioGRID Reconstituted Complex
ARC BioGRID SUMO1 GeneID BioGRID Affinity Capture-Western
ARC BioGRID SUMO2 GeneID BioGRID Affinity Capture-Western
ARC BioGRID SUMO3 GeneID BioGRID Affinity Capture-Western
ARC BioGRID RNF216 GeneID BioGRID Affinity Capture-Western
ARC BioGRID UBE3A GeneID BioGRID Reconstituted Complex
ARC Protein KRT15 GeneID HPRD
ARC BioGRID KRT15 GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
ARC TBR1 0 0 154 172 1 1
ARC GRIPAP1 0 0 213 213 1 1
ARC GABRA1 0 0 74 154 1 1
ARC OXT 0 0 138 198 1 1
ARC ANKRD13D 0 0 75 189 1 1
ARC EGR4 0 0 326 390 1 1
ARC MTOR 0 0 256 266 1 2
ARC CDC37L1 0 0 222 364 1 1
ARC PRRT1 0 0 119 185 1 1
ARC ZNF606 0 0 178 339 1 1
ARC PSEN2 0 0 113 415 1 1
ARC CDC42 0 0 142 165 1 2
ARC MPP1 0 0 0 163 1 1
ARC HCN2 0 0 0 156 1 1
ARC GRIP1 0 0 325 362 1 1
ARC DLGAP4 0 0 69 204 1 1
ARC SRC 0 0 170 189 1 2
ARC ADAM22 0 0 421 453 1 1
ARC GRM8 0 0 112 515 1 1
ARC DBNL 0 0 0 156 1 1
ARC BEND6 0 0 82 179 1 1
ARC CAMK2D 0 0 0 313 1 1
ARC TFPI2 0 0 0 189 1 1
ARC RPS6 0 0 204 204 1 2
ARC CXXC1 0 0 72 441 1 1
ARC GAD1 0 0 289 335 1 1
ARC HTR2A 0 0 157 177 1 1
ARC MPP5 0 0 0 163 1 1
ARC GRM7 0 0 91 343 1 1
ARC ZBTB24 0 0 95 247 1 1
ARC DCX 0 0 240 239 1 1
ARC SUMO2 270 0 124 355 1 1
ARC SLC17A7 0 0 218 263 1 1
ARC PPP1R18 0 0 137 324 1 1
ARC BAI3 0 0 91 172 1 1
ARC GRIK3 0 0 60 219 1 1
ARC WNT7A 0 0 155 154 1 1
ARC ZNF841 0 0 261 261 1 1
ARC SEMA3F 0 0 113 165 1 1
ARC DLG2 0 0 341 525 1 1
ARC SPINT2 0 0 0 189 1 1
ARC DNM3 0 0 257 442 1 1
ARC CACNA1C 0 0 125 156 1 1
ARC IQSEC2 0 0 248 284 1 1
ARC LYNX1 0 0 156 197 1 1
ARC HAP1 0 0 137 175 1 1
ARC APLP2 0 0 0 341 1 1
ARC CLSTN3 0 0 0 207 1 1
ARC GRM6 0 0 57 237 1 1
ARC EGR1 0 900 632 964 1 2
ARC APP 0 0 418 735 1 2
ARC GRIK1 0 0 0 162 1 1
ARC NAB1 0 0 120 152 1 1
ARC UBE3A 270 0 413 565 1 1
ARC PPP1R9B 0 0 322 380 1 1
ARC AKT1 0 0 260 260 1 2
ARC IMPA1 0 0 108 160 1 1
ARC SEMA7A 0 0 108 202 1 1
ARC PRKCG 0 0 247 301 1 1
ARC SYT4 0 0 109 215 1 1
ARC SUMO1 270 0 157 430 1 1
ARC CARD14 0 0 0 183 1 1
ARC LHFPL4 0 0 57 202 1 1
ARC ADCYAP1 0 0 136 188 1 1
ARC DDN 0 0 242 321 1 1
ARC GPR3 0 0 74 215 1 1
ARC KCNB1 0 0 113 155 1 2
ARC NTRK2 0 0 468 504 1 1
ARC CX3CL1 0 0 83 175 1 1
ARC DLG1 0 0 231 428 1 1
ARC CCDC85A 0 0 142 163 1 1
ARC RNF216 486 0 262 640 1 1
ARC GAPDH 0 0 246 245 1 2
ARC EGR3 0 900 267 928 1 1
ARC DISC1 0 0 134 173 1 1
ARC CCK 0 0 90 164 1 1
ARC GRM5 0 0 504 534 1 1
ARC PCDH8 0 0 66 154 1 1
ARC CREB1 0 900 564 955 1 2
ARC NLGN3 0 0 139 185 1 1
ARC CALB2 0 0 119 158 1 1
ARC ARHGEF15 0 0 344 343 1 1
ARC LGI2 0 0 160 204 1 1
ARC EIF4EBP1 0 0 134 152 1 2
ARC GRIK4 0 0 81 237 1 1
ARC CREBBP 0 0 248 264 1 1
ARC MOV10 0 0 108 152 1 1
ARC COTL1 0 0 0 156 1 1
ARC CREM 0 0 101 162 1 1
ARC GRIK2 0 0 170 282 1 1
ARC SYNGAP1 0 0 224 407 1 1
ARC NCS1 0 0 109 194 1 1
ARC SYNGR1 0 0 109 183 1 1
ARC RELN 0 0 261 262 1 1
ARC TH 0 0 156 157 1 2
ARC GRIA4 0 0 325 430 1 1
ARC WASL 0 0 95 157 1 1
ARC GRIA2 0 0 520 624 1 1
ARC CLPTM1 0 0 106 560 1 1
ARC NGF 0 0 261 286 1 2
ARC CYFIP1 0 0 342 451 1 1
ARC HIST1H1A 0 0 194 194 1 1
ARC CACNG2 0 0 350 425 1 1
ARC SHANK1 0 0 321 355 1 1
ARC SYNPO 0 0 179 196 1 1
ARC CAMKV 0 0 81 186 1 1
ARC NGDN 0 0 220 225 1 1
ARC BMF 0 0 0 302 1 1
ARC MEF2D 0 900 90 905 1 2
ARC SH3GL3 0 800 729 945 1 1
ARC SLC6A1 0 0 113 159 1 1
ARC ZBTB39 0 0 181 263 1 1
ARC REST 0 0 113 194 1 2
ARC FGF2 0 0 117 152 1 2
ARC NPY 0 0 314 335 1 1
ARC CYB5D1 0 0 181 181 1 1
ARC GRIN3B 0 0 66 272 1 1
ARC CASK 0 0 45 385 1 1
ARC NRN1 0 0 274 300 1 1
ARC CNR1 0 0 248 252 1 1
ARC ZNF442 0 0 0 209 1 1
ARC CARD10 0 0 0 183 1 1
ARC EPB41L1 0 0 167 197 1 1
ARC WFDC8 0 0 0 189 1 1
ARC MECP2 0 0 294 304 1 1
ARC SYNE1 0 0 276 290 1 1
ARC EHMT2 0 0 134 156 1 2
ARC GRIA3 0 0 278 369 1 1
ARC DAB2IP 0 0 0 213 1 2
ARC TBX18 240 0 0 239 1 1
ARC PPP1R1B 0 0 261 294 1 1
ARC FAM151B 0 0 234 247 1 1
ARC SRR 0 0 211 211 1 1
ARC NLGN2 0 0 156 222 1 1
ARC KALRN 0 0 210 257 1 1
ARC MPP3 0 0 0 187 1 1
ARC TPH1 0 0 82 241 1 1
ARC GABRG2 0 0 87 211 1 1
ARC ZNF268 0 0 181 181 1 1
ARC TNF 0 0 112 150 1 2
ARC SNAP25 0 0 147 210 1 1
ARC SLC1A3 0 0 66 187 1 1
ARC IP6K1 0 0 122 154 1 1
ARC PFN4 0 0 180 185 1 1
ARC DLGAP2 0 0 96 219 1 1
ARC KCND2 0 0 169 210 1 1
ARC HTR2C 0 0 156 195 1 1
ARC NR4A2 0 0 181 221 1 1
ARC BDNF 0 0 686 710 1 2
ARC SLC6A4 0 0 166 184 1 1
ARC NCSTN 0 0 61 199 1 1
ARC WFDC13 0 0 0 189 1 1
ARC SYN2 0 0 95 168 1 1
ARC HHIP 0 0 0 189 1 1
ARC NR4A3 0 0 101 175 1 1
ARC EEF2 0 0 469 478 1 2
ARC FNIP2 0 0 95 236 1 1
ARC MAP2 0 0 359 419 1 2
ARC PPP1R15A 0 0 139 192 1 2
ARC RBFOX3 0 0 377 390 1 1
ARC FMR1 0 0 517 534 1 1
ARC GRM4 0 0 134 268 1 1
ARC GRID1 0 0 49 208 1 2
ARC BRS3 0 0 0 183 1 1
ARC NLGN1 0 0 170 188 1 1
ARC DLGAP3 0 0 457 532 1 1
ARC STMN4 0 0 66 197 1 1
ARC TMEM243 0 0 166 165 1 1
ARC CTBP2 0 0 108 244 1 1
ARC VGF 0 0 217 296 1 1
ARC LIMD1 0 0 107 180 1 1
ARC NR4A1 0 0 285 421 1 2
ARC MRPS23 0 0 125 213 1 1
ARC MDGA1 0 0 0 238 1 1
ARC HPCA 0 0 54 186 1 1
ARC CACNA1D 0 0 49 153 1 1
ARC RHEB 0 0 123 163 1 2
ARC KCNJ4 0 0 212 285 1 1
ARC SEMA3B 0 0 49 267 1 1
ARC FAM65B 0 0 90 169 1 1
ARC DLGAP1 0 0 322 443 1 1
ARC EIF2AK4 0 0 86 166 1 2
ARC GRIK5 0 0 137 305 1 1
ARC INADL 0 0 0 183 1 1
ARC GSE1 0 0 108 217 1 1
ARC HMHA1 0 0 108 300 1 1
ARC ENSG00000267748 0 0 0 189 1 1
ARC STAU2 0 0 181 249 1 1
ARC GRIA1 0 0 667 723 1 1
ARC RASA1 0 0 0 151 1 1
ARC SLC39A8 0 0 0 432 1 1
ARC GDNF 0 0 161 161 1 2
ARC PTK2B 0 0 90 154 1 1
ARC TRIL 0 0 107 219 1 1
ARC STAU1 0 0 143 167 1 1
ARC HOMER2 0 0 183 200 1 1
ARC EIF4E 0 0 322 321 1 2
ARC RAPGEF5 0 0 0 188 1 1
ARC HTT 0 0 134 195 1 2
ARC RPS6KB1 0 0 232 248 1 2
ARC EGR2 0 900 233 932 1 1
ARC NPFF 0 0 91 178 1 1
ARC MAOA 0 0 122 176 1 1
ARC DRD1 0 0 218 338 1 1
ARC SGK1 0 0 134 175 1 2
ARC MPP6 0 0 0 231 1 1
ARC KCNA1 0 0 143 193 1 1
ARC PRDM10 0 0 103 245 1 1
ARC ZNF823 0 0 69 367 1 1
ARC GUK1 0 0 61 169 1 1
ARC GABRA5 0 0 123 189 1 1
ARC NGEF 0 0 124 164 1 1
ARC HDAC2 0 0 195 196 1 1
ARC AKAP5 0 0 137 171 1 1
ARC ARPC2 0 0 0 228 1 1
ARC JUND 0 900 63 904 1 1
ARC FAM26E 0 0 218 218 1 1
ARC NRXN3 0 0 143 163 1 1
ARC RNF149 0 0 108 171 1 1
ARC MPP7 0 0 0 163 1 1
ARC LRGUK 0 0 0 151 1 1
ARC AMPH 0 0 163 219 1 1
ARC AGR3 0 0 213 269 1 1
ARC ZNF862 0 0 194 194 1 1
ARC IGF2BP1 0 0 212 212 1 1
ARC NTF4 0 0 109 151 1 1
ARC GAD2 0 0 242 291 1 1
ARC NRXN1 0 0 243 261 1 1
ARC NRGN 0 0 374 612 1 1
ARC NEFL 0 0 67 184 1 1
ARC CA4 0 0 120 198 1 1
ARC ELFN2 0 0 151 316 1 1
ARC MAGI3 0 0 0 152 1 1
ARC DNM2 0 800 530 919 1 1
ARC FOSB 0 900 271 926 1 1
ARC MAP1B 0 0 505 536 1 2
ARC TFPI 0 0 0 189 1 1
ARC HTR1A 0 0 128 178 1 1
ARC BTG2 0 0 81 167 1 1
ARC ZDHHC22 0 0 0 153 1 1
ARC DLG4 270 0 733 935 1 2
ARC CLTB 0 0 90 201 1 1
ARC DRD2 0 0 230 272 1 1
ARC GFAP 0 0 208 239 1 2
ARC OPHN1 0 0 315 362 1 1
ARC SPINT3 0 0 0 189 1 1
ARC PVALB 0 0 346 392 1 1
ARC SPTBN4 270 0 92 353 1 1
ARC MBP 0 0 202 446 1 2
ARC NPAS1 0 0 95 213 1 1
ARC CYFIP2 0 0 0 173 1 1
ARC DNM1L 0 0 0 151 1 2
ARC CLPTM1L 0 0 0 260 1 1
ARC TFPT 0 0 0 175 1 1
ARC QDPR 0 0 0 248 1 1
ARC NTRK3 0 0 95 476 1 1
ARC KIF17 0 0 120 194 1 1
ARC ALB 0 0 171 185 1 2
ARC SORCS3 0 0 160 182 1 1
ARC CD200 0 0 66 209 1 1
ARC DBN1 0 0 0 224 1 1
ARC PLXNC1 0 0 108 169 1 1
ARC AMBP 0 0 0 189 1 1
ARC SH3GL1 0 0 802 810 1 1
ARC VAMP2 0 0 164 191 1 1
ARC NPTX2 0 0 373 450 1 1
ARC CDK5 0 0 336 340 1 2
ARC CFL1 0 0 370 370 1 1
ARC SLC17A6 0 0 113 153 1 1
ARC RASAL2 0 0 0 184 1 1
ARC NGFR 0 0 143 181 1 1
ARC RGS2 0 0 210 217 1 1
ARC NRXN2 0 0 139 209 1 1
ARC PPFIA3 0 0 131 199 1 1
ARC ZNF432 0 0 160 159 1 1
ARC IER2 0 0 150 206 1 1
ARC PTCHD2 0 0 118 228 1 1
ARC RASAL3 0 0 0 151 1 1
ARC EIF4A3 0 0 178 208 1 1
ARC ITPR1 0 0 166 165 1 2
ARC MPP2 0 0 195 398 1 1
ARC SLC1A2 0 0 108 186 1 1
ARC HOMER1 0 0 636 644 1 1
ARC BACE1 0 0 257 256 1 2
ARC RPS6KA3 0 0 125 156 1 1
ARC GADD45B 0 0 183 183 1 1
ARC CTXN1 0 0 0 184 1 1
ARC PLK2 0 0 257 256 1 1
ARC MAPK9 0 0 0 208 1 2
ARC ADCY8 0 0 181 228 1 1
ARC FMNL2 0 0 92 187 1 1
ARC ATAD1 0 0 112 152 1 1
ARC NES 0 0 119 159 1 2
ARC DLG5 0 0 0 183 1 1
ARC CAMK2G 0 0 0 345 1 1
ARC SYP 0 0 376 393 1 1
ARC GRIN1 0 0 294 755 1 1
ARC ACHE 0 0 123 155 1 2
ARC CRH 0 0 218 240 1 1
ARC PDZD2 0 0 0 183 1 1
ARC GRM2 0 0 211 265 1 1
ARC EPPIN 0 0 0 189 1 1
ARC SLC6A3 0 0 171 189 1 1
ARC CRHR1 0 0 81 167 1 1
ARC WFDC6 0 0 0 189 1 1
ARC GPHN 0 0 171 172 1 1
ARC CPEB1 0 0 166 184 1 1
ARC HNRNPA2B1 0 0 224 249 1 1
ARC GRIP2 0 0 150 169 1 1
ARC PIGY 0 0 0 189 1 1
ARC LRFN2 0 0 95 208 1 1
ARC KCNV1 0 0 134 201 1 1
ARC SNAP91 0 0 125 167 1 1
ARC HOMER3 0 0 215 232 1 1
ARC ZFP14 0 0 181 181 1 1
ARC GRM3 0 0 142 187 1 1
ARC STOX2 0 0 150 316 1 1
ARC S100P 237 0 0 237 1 1
ARC HIST2H3PS2 0 0 244 243 1 1
ARC ARL4D 0 0 139 181 1 1
ARC KCTD13 0 0 141 212 1 1
ARC STMN1 0 0 86 160 1 1
ARC LRRC4C 0 0 75 172 1 1
ARC CAMK2A 0 0 324 649 1 2
ARC SHANK2 0 0 242 258 1 1
ARC FBXO40 0 0 72 171 1 1
ARC ADAM11 0 0 0 153 1 1
ARC SUMO3 270 0 67 313 1 1
ARC ZNF594 0 0 201 201 1 1
ARC RASL11B 0 0 108 243 1 1
ARC KRAS 128 0 0 150 1 2
ARC RASD1 0 0 57 163 1 1
ARC GRIN2D 0 0 90 292 1 1
ARC DTNBP1 0 0 159 158 1 1
ARC CHRNB4 0 0 113 174 1 1
ARC CSRP2 272 0 0 272 1 1
ARC DNM1 0 0 101 271 1 1
ARC FER 273 0 0 273 1 1
ARC PDYN 0 0 278 334 1 1
ARC UPF1 0 0 167 167 1 1
ARC CAMK4 0 0 234 251 1 1
ARC ARHGAP44 0 0 108 201 1 1
ARC GAP43 0 0 124 188 1 1
ARC APBB1 0 0 53 413 1 1
ARC KIAA0020 0 0 150 373 1 1
ARC FRMPD1 0 0 167 186 1 1
ARC BSN 0 0 90 162 1 2
ARC ZNF490 0 0 163 189 1 1
ARC KCNG1 0 0 141 168 1 1
ARC FAM83B 179 0 0 179 1 1
ARC PENK 0 0 170 205 1 1
ARC FOS 0 900 652 966 1 2
ARC GRIN2A 0 0 459 584 1 1
ARC FYN 0 0 210 216 1 1
ARC TET3 0 0 150 181 1 1
ARC APLP1 0 0 0 317 1 1
ARC TMUB1 0 0 95 194 1 1
ARC JUN 0 0 247 279 1 2
ARC STMN3 0 0 52 186 1 1
ARC CARD11 0 0 0 183 1 1
ARC GRID2 0 0 57 206 1 2
ARC GABBR1 0 0 150 194 1 1
ARC NPTXR 0 0 147 228 1 1
ARC KIAA1147 0 0 181 181 1 1
ARC CALB1 0 0 134 172 1 1
ARC GRIN2C 0 0 100 316 1 1
ARC NAB2 0 0 136 216 1 1
ARC MPP4 0 0 0 163 1 1
ARC HRH3 0 0 49 272 1 1
ARC ENSG00000256825 0 0 193 193 1 1
ARC SRF 0 900 288 927 1 1
ARC CHRNA7 0 0 136 171 1 1
ARC PICK1 0 0 451 451 1 1
ARC GRIN2B 0 0 643 775 1 1
ARC FBXL19 0 0 0 169 1 1
ARC TEX2 0 0 136 171 1 1
ARC CAMK2B 0 0 152 617 1 1
ARC SNCA 0 0 150 207 1 2
ARC MAPT 0 0 182 218 1 2
ARC EIF4EBP2 0 0 217 217 1 1
ARC COLQ 0 0 90 230 1 1
ARC SPINT1 0 0 0 189 1 1
ARC RTN4R 0 0 45 157 1 1
ARC EEF2K 0 0 298 303 1 2
ARC EIF2AK1 0 0 71 278 1 1
ARC TET1 0 0 183 188 1 1
ARC DLG3 0 0 254 436 1 1
ARC SPINT4 0 0 0 189 1 1
ARC KCNF1 0 0 0 172 1 1
ARC JUNB 0 900 82 908 1 1
ARC GABRD 0 0 87 162 1 1
ARC MAPK3 0 0 296 302 1 2
ARC ACR 0 0 119 208 1 1
ARC GRM1 0 0 415 445 1 1
ARC STK38 0 0 67 161 1 1
ARC SARAF 0 0 92 247 1 1
ARC TMEM59L 0 0 0 171 1 1
ARC BAIAP2 0 0 134 165 1 1
ARC WAP7 0 0 0 189 1 1
ARC DNMT1 0 0 181 181 1 2
ARC CAMK2N2 0 0 181 255 1 1
ARC PTPN5 0 0 377 422 1 1
ARC PHACTR2 0 0 122 265 1 1
ARC GPR6 0 0 0 153 1 1
ARC NDE1 129 0 66 151 1 1
ARC RASGRF1 0 0 139 203 1 1
ARC SLC1A1 0 0 66 230 1 1
ARC ZFP28 0 0 152 286 1 1
ARC SLITRK3 0 0 100 219 1 1
ARC ACTB 0 0 283 292 1 2
ARC SH3GL2 0 0 171 230 1 1
ARC MYO5B 0 0 150 160 1 1
ARC LIMK1 0 0 195 223 1 1
ARC CNTNAP3 0 0 134 169 1 1
ARC PSEN1 0 0 323 672 1 2
ARC SYT1 0 0 123 188 1 1
ARC PTGS2 0 0 130 168 1 2
ARC C2CD4C 0 0 167 393 1 1
ARC EEF1A1 0 0 180 197 1 1
ARC CHRNB3 0 0 123 153 1 1
ARC ZDHHC2 0 0 157 185 1 1
ARC SLITRK1 0 0 90 241 1 1
ARC ZNF804A 0 0 134 180 1 1
ARC GABRB3 0 0 167 185 1 1
ARC FOSL1 0 900 75 903 1 1
ARC HIC2 0 0 124 261 1 1
ARC NPAS4 0 0 566 605 1 1
ARC MEF2A 0 0 150 181 1 1
ARC MRPL18 0 0 194 195 1 1
ARC APBB2 0 0 0 219 1 1
ARC SYN1 0 0 414 458 1 1
ARC STX1A 0 0 96 186 1 1
ARC EIF4G1 0 0 180 179 1 2
ARC SST 0 0 180 201 1 1
ARC SLC32A1 0 0 161 207 1 1
ARC GRIN3A 0 0 209 425 1 1
ARC SIK1 0 0 112 167 1 1
ARC GSK3B 0 0 139 192 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0003729 Molecular Function mRNA binding enables ISS
GO:0005515 Molecular Function protein binding enables IPI
GO:0009952 Biological Process anterior/posterior pattern specification involved_in IEA
GO:0016477 Biological Process cell migration involved_in IMP
GO:0007010 Biological Process cytoskeleton organization involved_in IBA
GO:0007010 Biological Process cytoskeleton organization involved_in IMP
GO:0060997 Biological Process dendritic spine morphogenesis involved_in TAS
GO:0006897 Biological Process endocytosis involved_in IEA
GO:0007492 Biological Process endoderm development involved_in IEA
GO:0007612 Biological Process learning involved_in IEA
GO:0007616 Biological Process long-term memory involved_in ISS
GO:0007616 Biological Process long-term memory involved_in TAS
GO:0060291 Biological Process long-term synaptic potentiation involved_in TAS
GO:0051028 Biological Process mRNA transport involved_in ISS
GO:0050804 Biological Process modulation of chemical synaptic transmission involved_in ISS
GO:2000969 Biological Process positive regulation of AMPA receptor activity involved_in IBA
GO:0051260 Biological Process protein homooligomerization involved_in ISS
GO:0022604 Biological Process regulation of cell morphogenesis involved_in IMP
GO:0061001 Biological Process regulation of dendritic spine morphogenesis involved_in ISS
GO:1900452 Biological Process regulation of long-term synaptic depression involved_in ISS
GO:1900271 Biological Process regulation of long-term synaptic potentiation involved_in IBA
GO:1900271 Biological Process regulation of long-term synaptic potentiation involved_in ISS
GO:0048168 Biological Process regulation of neuronal synaptic plasticity involved_in IBA
GO:0099149 Biological Process regulation of postsynaptic neurotransmitter receptor internalization involved_in IEA
GO:0110077 Biological Process vesicle-mediated intercellular transport involved_in ISS
GO:0001669 Cellular Component acrosomal vesicle located_in IEA
GO:0015629 Cellular Component actin cytoskeleton is_active_in IBA
GO:0005938 Cellular Component cell cortex located_in IEA
GO:0030665 Cellular Component clathrin-coated vesicle membrane located_in IEA
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0043197 Cellular Component dendritic spine located_in ISS
GO:0031901 Cellular Component early endosome membrane located_in IEA
GO:1903561 Cellular Component extracellular vesicle located_in ISS
GO:0098978 Cellular Component glutamatergic synapse located_in IEA
GO:0045121 Cellular Component membrane raft located_in ISS
GO:0043025 Cellular Component neuronal cell body located_in TAS
GO:0071598 Cellular Component neuronal ribonucleoprotein granule located_in IEA
GO:0005886 Cellular Component plasma membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0098839 Cellular Component postsynaptic density membrane located_in IEA
GO:0098845 Cellular Component postsynaptic endosome located_in IEA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Signaling by NTRKs Reactome R-HSA-166520
Signaling by NTRK1 (TRKA) Reactome R-HSA-187037
Nuclear Events (kinase and transcription factor activation) Reactome R-HSA-198725
Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
NGF-stimulated transcription Reactome R-HSA-9031628
Neuroinflammation and glutamatergic signaling (WP5083) WikiPathways WP5083_r120385
Serotonin and anxiety-related events (WP3944) WikiPathways WP3944_r120596
Fragile X syndrome (WP4549) WikiPathways WP4549_r124287
Disruption of postsynaptic signaling by CNV (WP4875) WikiPathways WP4875_r116427
BDNF-TrkB signaling (WP3676) WikiPathways WP3676_r116809
Synaptic signaling pathways associated with autism spectrum disorder (WP4539) WikiPathways WP4539_r113659
Serotonin and anxiety (WP3947) WikiPathways WP3947_r106483
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_015193 5 mRNA transcript variant 1 NC_000008 Reference
NM_001412852 1 mRNA transcript variant 2 NC_000008 Reference