FN1

fibronectin 1

General Information

Name	fibronectin 1
Alias	fibronectin cold-insoluble globulin epididymis secretory sperm binding protein lnc-ABCA12-8 migration-stimulating factor
Gene_family	Fibronectin type III domain containing\|Receptor ligands
organism	Homo sapiens
entrez_id	2335
location	2q35
transcript_count	18
exon_count	47

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

Stringdb Fibronectin type III domain containing; Endogenous ligands

nextProt Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Interactions

NCBI

Show entries

Search:


FN1	BioGRID	TLE2	GeneID	BioGRID	Proximity Label-MS
FN1	BioGRID	PAFAH1B1	GeneID	BioGRID	Proximity Label-MS
FN1	BioGRID	HDLBP	GeneID	BioGRID	Affinity Capture-MS
FN1	BioGRID	RAF1	GeneID	BioGRID	Affinity Capture-MS
FN1	BioGRID	TLR4	GeneID	BioGRID	Reconstituted Complex
FN1	BioGRID	COL9A1	GeneID	BioGRID	Reconstituted Complex; Two-hybrid
FN1	BioGRID	ZRANB1	GeneID	BioGRID	Affinity Capture-MS
FN1	BioGRID	ARL6	GeneID	BioGRID	Proximity Label-MS
FN1	BioGRID	ITGB1	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
FN1	BioGRID	ARF1	GeneID	BioGRID	Proximity Label-MS

Showing 1 to 10 of 883 entries

StringDB

Show entries

Search:


FN1	PLCE1	0	0	123	155	1	1
FN1	SLC16A8	0	0	457	457	1	1
FN1	ETV2	0	0	167	167	1	1
FN1	SEMA4G	0	0	391	390	1	1
FN1	MYO1B	0	0	107	199	1	1
FN1	ATP2A2	0	0	244	274	1	1
FN1	WIPF1	0	0	167	167	1	1
FN1	MYH2	0	900	261	922	1	1
FN1	PHOX2B	0	0	160	166	1	1
FN1	PSMA7	74	0	164	192	1	1

Showing 1 to 10 of 3,501 entries

Ontologies

Show entries

Search:


GO:0001525	Biological Process	angiogenesis	involved_in	IEA
GO:0001932	Biological Process	regulation of protein phosphorylation	involved_in	IDA
GO:0002020	Molecular Function	protease binding	enables	IPI
GO:0005102	Molecular Function	signaling receptor binding	enables	IDA
GO:0005178	Molecular Function	integrin binding	enables	IBA
GO:0005178	Molecular Function	integrin binding	enables	IDA
GO:0005178	Molecular Function	integrin binding	enables	IMP
GO:0005178	Molecular Function	integrin binding	enables	IPI
GO:0005201	Molecular Function	extracellular matrix structural constituent	enables	HDA
GO:0005201	Molecular Function	extracellular matrix structural constituent	enables	ISS

Showing 1 to 10 of 66 entries

Pathways

Show entries

Search:


ALK mutants bind TKIs	Reactome	R-HSA-9700645
Burn wound healing (WP5055)	WikiPathways	WP5055_r122621
CCL18 signaling pathway (WP5097)	WikiPathways	WP5097_r119075
Cell surface interactions at the vascular wall	Reactome	R-HSA-202733
Cytokine Signaling in Immune system	Reactome	R-HSA-1280215
Degradation of the extracellular matrix	Reactome	R-HSA-1474228
Disease	Reactome	R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers	Reactome	R-HSA-5663202
ECM proteoglycans	Reactome	R-HSA-3000178
Elastic fibre formation	Reactome	R-HSA-1566948

Showing 1 to 10 of 76 entries

Transcripts

Show entries

Search:


NM_001306129	2	mRNA	transcript variant 8	NC_000002	Reference
NM_001306130	2	mRNA	transcript variant 9	NC_000002	Reference
NM_001306131	2	mRNA	transcript variant 10	NC_000002	Reference
NM_001306132	2	mRNA	transcript variant 11	NC_000002	Reference
NM_001365517	2	mRNA	transcript variant 12	NC_000002	Reference
NM_001365518	2	mRNA	transcript variant 13	NC_000002	Reference
NM_001365519	2	mRNA	transcript variant 14	NC_000002	Reference
NM_001365520	2	mRNA	transcript variant 15	NC_000002	Reference
NM_001365521	2	mRNA	transcript variant 16	NC_000002	Reference
NM_001365522	2	mRNA	transcript variant 17	NC_000002	Reference

Showing 1 to 10 of 18 entries