GFAP

glial fibrillary acidic protein

General Information

Name	glial fibrillary acidic protein
Alias	glial fibrillary acidic protein
Gene_family	Intermediate filaments Type III
organism	Homo sapiens
entrez_id	2670
location	17q21.31
transcript_count	4
exon_count	10

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Stringdb Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells

nextProt GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Interactions

NCBI

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GFAP	BioGRID	EZH2	GeneID	BioGRID	Affinity Capture-MS
GFAP	BioGRID	FOXO1	GeneID	BioGRID	Proximity Label-MS
GFAP	BioGRID	TRIM67	GeneID	BioGRID	Affinity Capture-MS
GFAP	BioGRID	ACE2	GeneID	BioGRID	Affinity Capture-MS
GFAP	BioGRID	PRKN	GeneID	BioGRID	Affinity Capture-MS
GFAP	BioGRID	MYCN	GeneID	BioGRID	Affinity Capture-MS
GFAP	BioGRID	NEIL3	GeneID	BioGRID	Protein-RNA
GFAP	BioGRID	GBA1	GeneID	BioGRID	Affinity Capture-MS
GFAP	BioGRID	APP	GeneID	BioGRID	Affinity Capture-MS; Reconstituted Complex
GFAP	BioGRID	UBALD2	GeneID	BioGRID	Affinity Capture-MS

Showing 1 to 10 of 233 entries

StringDB

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GFAP	RIC8B	0	423	422	1	1
GFAP	HIST2H2BE	0	181	181	1	1
GFAP	ACY3	0	0	196	1	1
GFAP	CHMP4B	270	0	270	1	2
GFAP	SCG3	0	81	234	1	1
GFAP	OLIG2	0	858	939	1	1
GFAP	HEY1	0	212	246	1	1
GFAP	YWHAQ	0	259	396	1	1
GFAP	DRP2	0	0	150	1	1
GFAP	LHB	0	297	297	1	1

Showing 1 to 10 of 2,247 entries

Ontologies

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GO:0005178	Molecular Function	integrin binding	enables	IEA
GO:0005200	Molecular Function	structural constituent of cytoskeleton	enables	IBA
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0005737	Cellular Component	cytoplasm	is_active_in	IBA
GO:0005737	Cellular Component	cytoplasm	located_in	IDA
GO:0005764	Cellular Component	lysosome	colocalizes_with	ISS
GO:0005829	Cellular Component	cytosol	located_in	TAS
GO:0005882	Cellular Component	intermediate filament	is_active_in	IBA
GO:0006886	Biological Process	intracellular protein transport	involved_in	IEA
GO:0010467	Biological Process	gene expression	involved_in	IEA

Showing 1 to 10 of 33 entries

Pathways

Name	DB	ID
Signaling by ERBB4	Reactome	R-HSA-1236394
Nuclear signaling by ERBB4	Reactome	R-HSA-1251985
Signal Transduction	Reactome	R-HSA-162582
Signaling by Receptor Tyrosine Kinases	Reactome	R-HSA-9006934
Autophagy	Reactome	R-HSA-9612973
Chaperone Mediated Autophagy	Reactome	R-HSA-9613829
Neural crest differentiation (WP2064)	WikiPathways	WP2064_r117162
Neuroinflammation and glutamatergic signaling (WP5083)	WikiPathways	WP5083_r120385
Spinal cord injury (WP2431)	WikiPathways	WP2431_r120812

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_002055	5	mRNA	transcript variant 1	NC_000017	Reference
NM_001363846	2	mRNA	transcript variant 4	NC_000017	Reference
NM_001131019	3	mRNA	transcript variant 2	NC_000017	Reference
NM_001242376	3	mRNA	transcript variant 3	NC_000017	Reference