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PELP1

proline, glutamate and leucine rich protein 1
General Information
Name proline, glutamate and leucine rich protein 1
Alias
  • proline-, glutamic acid- and leucine-rich protein 1
  • modulator of non-genomic activity of estrogen receptor
  • proline and glutamic acid rich nuclear protein
  • transcription factor HMX3
Gene_family Large ribosomal subunit biogenesis complex|Armadillo like helical domain containing
organism Homo sapiens
entrez_id 27043
location 17p13.2
transcript_count 2
exon_count 19
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
    Stringdb Proline-, glutamic acid- and leucine-rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/ [...]
    nextProt Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
PELP1 BioGRID NUP43 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID SNRNP40 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID USP11 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID MYC GeneID BioGRID Proximity Label-MS
PELP1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID USP7 GeneID BioGRID Reconstituted Complex
PELP1 BioGRID SPPL3 GeneID BioGRID Positive Genetic
PELP1 BioGRID LAS1L GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PELP1 BioGRID WDR18 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Proximity Label-MS; Reconstituted Complex
PELP1 BioGRID TEX10 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
PELP1 BioGRID SENP3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PELP1 BioGRID CHTOP GeneID BioGRID Affinity Capture-Western
PELP1 BioGRID Tex10 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
PELP1 BioGRID Wdr18 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
PELP1 BioGRID Senp3 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
PELP1 BioGRID Las1l GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
PELP1 BioGRID Pelp1 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID Nol9 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID STIP1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CCNF GeneID BioGRID Proximity Label-MS
PELP1 BioGRID DOT1L GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SRPK3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID PRKD3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SYK GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SRPK2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SRPK1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID EIF2AK2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID MEN1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CSNK2A2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID ZMYND11 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CHD8 GeneID BioGRID Co-fractionation
PELP1 BioGRID PRPF40A GeneID BioGRID Co-fractionation
PELP1 BioGRID PRPF31 GeneID BioGRID Co-fractionation
PELP1 BioGRID MGA GeneID BioGRID Co-fractionation
PELP1 BioGRID WDR5 GeneID BioGRID Co-fractionation
PELP1 BioGRID RUVBL2 GeneID BioGRID Co-fractionation
PELP1 BioGRID ASH2L GeneID BioGRID Co-fractionation
PELP1 BioGRID RUVBL1 GeneID BioGRID Co-fractionation
PELP1 BioGRID TAF7 GeneID BioGRID Co-fractionation
PELP1 BioGRID RBBP5 GeneID BioGRID Co-fractionation
PELP1 BioGRID MAX GeneID BioGRID Co-fractionation
PELP1 BioGRID HSPA4 GeneID BioGRID Co-fractionation
PELP1 BioGRID HCFC1 GeneID BioGRID Co-fractionation
PELP1 BioGRID C9orf78 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID TP53 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
PELP1 BioGRID METAP2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RACK1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SRP68 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SRP9 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPL5 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID KRAS GeneID BioGRID Negative Genetic
PELP1 BioGRID EGFR GeneID BioGRID Negative Genetic
PELP1 BioGRID CALM3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SIRT6 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RCHY1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID BRD4 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NBR1 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID TOP3B GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID IFITM1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID TMPRSS2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CTSL GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CLEC4D GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID TMPRSS11B GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H2AB1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H1-7 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID ZNF467 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID ZC3H10 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RBM4B GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H2AB3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NOL9 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
PELP1 BioGRID ZBTB2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NEUROG3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CBX6 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NPM3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID FGFBP1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H2AC17 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H2AC4 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID FSCN1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPLP0 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPL13 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPL10 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPL3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NPM1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID IPO5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
PELP1 BioGRID H2AC8 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID EP300 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PELP1 BioGRID ATG3 GeneID BioGRID Phenotypic Suppression
PELP1 BioGRID ATG7 GeneID BioGRID Phenotypic Suppression
PELP1 BioGRID DDRGK1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID UFL1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID POLR1G GeneID BioGRID Proximity Label-MS
PELP1 BioGRID Apc2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID HULC GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SUMO2 GeneID BioGRID Reconstituted Complex
PELP1 BioGRID PYHIN1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CHMP4C GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID ANLN GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CIT GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID KIF20A GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID KIF23 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID MNDA GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID LDLR GeneID BioGRID Positive Genetic
PELP1 BioGRID IFI16 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID PTEN GeneID BioGRID Reconstituted Complex
PELP1 BioGRID FANCD2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID BIRC3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H4C1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
PELP1 BioGRID TCF7L2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H2AX GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPS6 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID CGAS GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID EZH2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RNF4 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID H3-3A GeneID BioGRID Reconstituted Complex
PELP1 BioGRID NR3C1 GeneID BioGRID Affinity Capture-Western
PELP1 BioGRID CHD3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID EFTUD2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID K4.1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
PELP1 BioGRID RPS2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID PHF19 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID FOXQ1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID MCM5 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID Eif3i GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID HERC2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID EWSR1 GeneID BioGRID Proximity Label-MS
PELP1 BioGRID HTATSF1 GeneID BioGRID Co-fractionation
PELP1 BioGRID NOLC1 GeneID BioGRID Co-fractionation
PELP1 BioGRID AP3B1 GeneID BioGRID Co-fractionation
PELP1 BioGRID PIP5K1A GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CDK11A GeneID BioGRID Co-fractionation
PELP1 BioGRID H2BC1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID BCAS3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
PELP1 BioGRID OBSL1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID CUL7 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID LGR4 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPA3 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPA2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPA1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RNF2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID NFKB1 GeneID BioGRID Reconstituted Complex
PELP1 BioGRID SOX2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID RPL26 GeneID BioGRID Affinity Capture-Western
PELP1 BioGRID RPL11 GeneID BioGRID Co-fractionation
PELP1 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID SMAD9 GeneID BioGRID Two-hybrid
PELP1 BioGRID FN1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID ESR1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex
PELP1 BioGRID ECT2 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID MDN1 GeneID BioGRID Co-fractionation
PELP1 BioGRID SNCA GeneID BioGRID Protein-peptide
PELP1 BioGRID SRC GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
PELP1 BioGRID HGS GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PELP1 BioGRID SIRT7 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID BLOC1S1 GeneID BioGRID Two-hybrid
PELP1 BioGRID SMARCAD1 GeneID BioGRID Affinity Capture-MS
PELP1 BioGRID AR GeneID BioGRID Affinity Capture-Western
PELP1 BioGRID KDM1A GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
PELP1 BioGRID H3C1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
PELP1 BioGRID H2BC21 GeneID BioGRID Reconstituted Complex
PELP1 BioGRID H2AC20 GeneID BioGRID Reconstituted Complex
PELP1 BioGRID STAT3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PELP1 BioGRID SRF GeneID BioGRID Co-localization
PELP1 BioGRID HDAC2 GeneID BioGRID Affinity Capture-Western; Co-localization
PELP1 BioGRID H1-1 GeneID BioGRID Reconstituted Complex
PELP1 BioGRID NR4A1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PELP1 Protein TOM1L1 GeneID HPRD
PELP1 Protein HGS GeneID HPRD
PELP1 Protein SMAD9 GeneID HPRD
PELP1 Protein EP300 GeneID HPRD
PELP1 Protein CREBBP GeneID HPRD
PELP1 Protein RB1 GeneID HPRD
PELP1 Protein BAG6 GeneID HPRD
PELP1 Protein ESR1 GeneID HPRD
PELP1 BioGRID TOM1L1 GeneID BioGRID Two-hybrid
PELP1 BioGRID BAG6 GeneID BioGRID Two-hybrid
PELP1 BioGRID CREBBP GeneID BioGRID Affinity Capture-Western
PELP1 BioGRID RB1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
PELP1 Protein RB1 GeneID BIND PELP1 interacts with pRb.
StringDB
A B experiments database textmining combined score hadb nhadb
PELP1 NUDT13 0 0 164 194 1 1
PELP1 BRCA1 0 0 142 173 1 2
PELP1 PRPF8 0 0 66 203 1 1
PELP1 STK11 0 0 95 255 1 2
PELP1 LSG1 0 0 116 154 1 1
PELP1 TAF7 0 900 0 900 1 1
PELP1 HNRNPU 0 0 134 181 1 1
PELP1 HIST1H2AE 270 0 82 301 1 1
PELP1 IGF1 0 900 384 935 1 2
PELP1 WDFY3 0 0 435 435 1 2
PELP1 STRN 0 0 568 605 1 1
PELP1 NCOA7 0 0 212 212 1 1
PELP1 LMTK3 0 0 203 218 1 1
PELP1 POLR2F 0 0 103 306 1 1
PELP1 NGDN 0 0 72 162 1 1
PELP1 THAP7 0 0 146 178 1 1
PELP1 HIST1H1A 270 0 0 270 1 1
PELP1 RPS25 0 0 108 182 1 1
PELP1 SOS1 0 900 0 909 1 1
PELP1 FHL2 0 0 725 729 1 1
PELP1 TOMM5 0 0 103 159 1 1
PELP1 MTA1 0 0 608 627 1 1
PELP1 ANP32A 0 0 137 162 1 1
PELP1 IFI16 486 0 0 521 1 1
PELP1 HDAC3 0 0 57 156 1 2
PELP1 RPRD2 0 0 58 157 1 1
PELP1 SRSF2 0 0 155 258 1 1
PELP1 C1orf64 0 0 180 179 1 1
PELP1 KMT2A 0 900 0 900 1 1
PELP1 PLEKHA4 270 0 0 270 1 1
PELP1 LEO1 0 0 134 289 1 1
PELP1 DDX17 0 0 97 191 1 1
PELP1 LAS1L 870 900 958 999 1 1
PELP1 NRIP1 0 0 247 246 1 1
PELP1 NEURL2 0 0 0 159 1 1
PELP1 PIK3CA 0 900 0 903 1 2
PELP1 TBX5 0 0 0 181 1 1
PELP1 FOLR4 0 0 100 194 1 1
PELP1 SLC9A5 0 0 0 174 1 1
PELP1 C14orf142 0 0 169 188 1 1
PELP1 NOL10 0 0 174 262 1 1
PELP1 RUVBL2 0 900 0 908 1 1
PELP1 OBSL1 270 0 0 274 1 1
PELP1 EFTUD2 240 0 0 327 1 1
PELP1 SLC7A1 0 0 277 277 1 1
PELP1 PSG5 0 0 218 218 1 1
PELP1 RNF4 270 0 61 335 1 1
PELP1 H1F0 0 0 444 444 1 1
PELP1 YBX1 0 0 82 182 1 1
PELP1 BCAS2 0 0 433 607 1 1
PELP1 PI3 0 0 163 163 1 2
PELP1 BLOC1S1 192 0 142 277 1 1
PELP1 VPS11 0 0 0 183 1 1
PELP1 TCERG1 0 0 81 155 1 1
PELP1 IL36G 0 0 68 278 1 1
PELP1 IGF1R 0 900 294 927 1 2
PELP1 PTMA 0 0 0 154 1 1
PELP1 DDX51 0 0 146 172 1 1
PELP1 ATXN7L3 0 0 141 182 1 1
PELP1 KIF18A 0 0 91 156 1 1
PELP1 HERC2 270 0 0 270 1 1
PELP1 DDX27 0 0 124 168 1 1
PELP1 CBX5 0 0 66 231 1 1
PELP1 ILK 0 0 846 846 1 1
PELP1 POLR2G 0 0 93 335 1 1
PELP1 FCGR1B 0 0 154 153 1 1
PELP1 PNRC2 0 0 638 652 1 1
PELP1 WDR12 0 600 107 645 1 1
PELP1 CHIA 0 0 431 431 1 1
PELP1 MYBBP1A 0 0 112 279 1 1
PELP1 PPRC1 0 0 72 246 1 1
PELP1 CHMP4C 270 0 0 270 1 1
PELP1 MYC 0 0 195 212 1 2
PELP1 STAT3 270 0 852 887 1 2
PELP1 EML2 0 0 95 342 1 1
PELP1 ERH 0 0 122 212 1 1
PELP1 NCOA1 0 0 433 439 1 1
PELP1 EXOSC10 0 0 93 162 1 1
PELP1 AGO2 270 0 0 270 1 2
PELP1 DDX5 0 0 93 166 1 1
PELP1 NR2F1 0 0 134 162 1 1
PELP1 CAT 0 0 294 294 1 2
PELP1 SLC9A4 0 0 0 158 1 1
PELP1 PAFAH1B3 0 0 122 180 1 1
PELP1 MDM1 0 0 0 258 1 1
PELP1 DYNLL1 0 0 357 357 1 1
PELP1 RBP2 0 0 77 443 1 1
PELP1 XRCC6 0 0 113 155 1 1
PELP1 PRPF31 0 900 0 902 1 1
PELP1 EXOSC7 0 0 95 252 1 1
PELP1 NR4A1 270 0 326 539 1 2
PELP1 HGS 270 0 852 891 1 2
PELP1 PCP4L1 0 0 62 165 1 1
PELP1 VPRBP 0 0 244 294 1 1
PELP1 EML1 0 0 67 321 1 1
PELP1 SRSF1 0 0 74 150 1 1
PELP1 MTA3 0 0 379 379 1 1
PELP1 KIF23 270 0 0 270 1 1
PELP1 MDN1 489 0 263 616 1 1
PELP1 AHCY 0 0 97 159 1 1
PELP1 JAK2 0 0 72 178 1 2
PELP1 C6orf57 0 0 0 303 1 1
PELP1 BCAS3 270 0 447 616 1 1
PELP1 HDAC2 270 0 716 797 1 1
PELP1 FGFR1OP 0 0 108 201 1 1
PELP1 GREB1 0 0 150 181 1 1
PELP1 BOP1 282 600 0 736 1 1
PELP1 GNL3 0 900 0 905 1 1
PELP1 SMTNL2 0 0 158 157 1 1
PELP1 SRPR 0 0 90 338 1 1
PELP1 AIMP1 0 0 74 174 1 1
PELP1 TTLL10 0 0 134 603 1 1
PELP1 CCND1 0 0 298 313 1 2
PELP1 NCOR2 0 0 231 261 1 1
PELP1 NOS3 0 0 167 167 1 2
PELP1 C1orf85 0 0 206 206 1 1
PELP1 LMNA 0 0 322 328 1 2
PELP1 TCOF1 0 0 108 202 1 1
PELP1 EGFR 0 0 508 508 1 2
PELP1 CDK4 0 0 478 490 1 2
PELP1 DMTF1 0 0 93 158 1 1
PELP1 KAT2B 0 0 166 176 1 1
PELP1 PGR 0 0 368 712 1 1
PELP1 LYZL6 0 0 218 266 1 1
PELP1 MUC1 0 0 437 437 1 1
PELP1 NCOR1 0 0 374 383 1 1
PELP1 DHX30 0 0 167 196 1 1
PELP1 HIST2H2BE 270 0 44 272 1 1
PELP1 TRIM24 0 0 183 216 1 1
PELP1 DDX54 0 0 142 247 1 1
PELP1 HTATSF1 272 0 0 272 1 1
PELP1 TP53 270 0 248 434 1 2
PELP1 MGA 0 900 0 906 1 1
PELP1 GART 0 0 75 193 1 1
PELP1 SKIV2L2 0 0 74 179 1 1
PELP1 UXT 0 0 90 282 1 1
PELP1 TAF9 0 900 0 900 1 1
PELP1 RPS6 129 0 0 159 1 2
PELP1 TRIM28 0 0 86 178 1 2
PELP1 E2F6 0 900 0 900 1 1
PELP1 SRSF12 0 0 170 201 1 1
PELP1 UBE2A 0 0 70 192 1 1
PELP1 LGALS3 0 0 320 319 1 2
PELP1 C9orf64 0 0 182 219 1 1
PELP1 RTF1 0 0 155 182 1 1
PELP1 LGR4 270 0 0 270 1 1
PELP1 MCRS1 0 900 0 902 1 1
PELP1 FGFBP2 0 0 112 173 1 1
PELP1 PIP 0 0 135 157 1 1
PELP1 ELP5 0 0 142 338 1 1
PELP1 DCXR 0 0 95 395 1 1
PELP1 EWSR1 114 0 67 179 1 1
PELP1 MYO1E 0 0 329 329 1 1
PELP1 TAF4 0 900 0 903 1 1
PELP1 DDX21 0 900 161 916 1 1
PELP1 POTEF 0 0 397 396 1 1
PELP1 MTOR 0 0 111 248 1 2
PELP1 SMARCAD1 270 0 0 270 1 1
PELP1 BRIX1 0 0 0 220 1 1
PELP1 C17orf49 0 900 0 900 1 1
PELP1 PDCD5 0 0 94 181 1 1
PELP1 RBM14-RBM4 0 0 183 183 1 1
PELP1 SRC 678 900 984 999 1 2
PELP1 PRMT1 0 0 261 298 1 1
PELP1 ABCD2 0 0 119 254 1 1
PELP1 STIL 0 0 72 170 1 1
PELP1 CDC42 0 0 73 167 1 2
PELP1 NOC2L 0 0 181 360 1 1
PELP1 RAD54L2 0 0 163 163 1 1
PELP1 HIST1H4F 486 0 0 485 1 1
PELP1 TENM2 0 0 0 189 1 1
PELP1 NOL9 872 600 364 965 1 1
PELP1 NOC3L 0 0 0 162 1 1
PELP1 STAT5B 0 0 107 176 1 1
PELP1 RHO 0 0 0 212 1 2
PELP1 BAZ1A 0 0 94 250 1 1
PELP1 POLR2B 0 0 126 237 1 1
PELP1 RB1 270 0 447 579 1 2
PELP1 DCAF6 0 0 261 261 1 1
PELP1 CTNNB1 0 0 134 152 1 2
PELP1 GTF2B 0 0 61 265 1 1
PELP1 HRAS 0 900 95 909 1 2
PELP1 MAP1LC3A 270 0 0 285 1 2
PELP1 CDK2 0 0 691 723 1 2
PELP1 MOV10L1 0 0 120 215 1 1
PELP1 PAX2 0 0 242 241 1 1
PELP1 CHTOP 0 0 317 535 1 1
PELP1 SUMO2 486 0 448 723 1 1
PELP1 CFAP20 0 0 107 187 1 1
PELP1 SP1 0 0 240 239 1 2
PELP1 RAC2 0 0 0 244 1 1
PELP1 RPL11 270 0 0 305 1 1
PELP1 RRP1B 270 0 124 410 1 1
PELP1 HIF1A 0 650 73 661 1 2
PELP1 RNF2 0 900 0 900 1 1
PELP1 CNTROB 0 0 124 429 1 1
PELP1 PTBP1 0 0 74 176 1 2
PELP1 NEURL1B 0 0 0 176 1 1
PELP1 MAP2K7 0 0 117 156 1 1
PELP1 SNW1 114 0 73 154 1 1
PELP1 ATRX 0 0 63 166 1 1
PELP1 GPR3 0 0 160 188 1 1
PELP1 PRDM4 0 0 115 151 1 1
PELP1 AKT1 0 900 391 938 1 2
PELP1 CARM1 0 0 934 940 1 2
PELP1 RPL13 128 0 0 162 1 1
PELP1 COPG1 0 0 114 187 1 1
PELP1 SF3A1 0 0 67 161 1 1
PELP1 SUMO1 0 0 141 201 1 1
PELP1 SAFB 0 0 140 227 1 1
PELP1 FOXA1 0 0 167 167 1 1
PELP1 SLC9A1 0 0 0 158 1 1
PELP1 RPL26 270 0 0 298 1 1
PELP1 BCAS4 0 0 161 161 1 1
PELP1 CUL7 270 0 0 270 1 1
PELP1 AP3B1 678 0 0 678 1 1
PELP1 ERBB2 0 0 392 392 1 2
PELP1 RPS3 0 0 97 194 1 1
PELP1 POLR2A 0 0 93 237 1 1
PELP1 ILF2 0 0 127 181 1 1
PELP1 RNASET2 0 0 92 169 1 1
PELP1 RRN3 0 0 54 313 1 1
PELP1 EFR3B 0 0 134 223 1 1
PELP1 GSG2 0 0 0 506 1 1
PELP1 SSRP1 0 0 150 222 1 1
PELP1 SUPT16H 0 0 123 183 1 1
PELP1 RALY 0 0 123 154 1 1
PELP1 CREB1 0 0 141 164 1 2
PELP1 PNPO 0 0 108 262 1 1
PELP1 NVL 0 0 194 194 1 1
PELP1 HIST2H2AC 270 0 123 332 1 1
PELP1 DHX9 0 0 126 187 1 1
PELP1 SIRT4 0 0 47 217 1 1
PELP1 JHDM3C 0 0 141 157 1 1
PELP1 DDX56 0 0 161 208 1 1
PELP1 PSMA1 0 0 93 165 1 1
PELP1 CREBBP 270 900 134 942 1 1
PELP1 RBBP5 0 900 54 903 1 1
PELP1 GPR18 0 0 74 158 1 1
PELP1 WDR3 0 0 0 154 1 1
PELP1 PHF20 0 900 46 900 1 1
PELP1 HNRNPUL2 0 0 138 229 1 1
PELP1 ESRRA 0 0 425 438 1 1
PELP1 NOP2 0 0 0 177 1 1
PELP1 OR8I2 0 0 194 194 1 1
PELP1 ATAD3A 0 0 0 165 1 1
PELP1 MYO1C 0 0 328 342 1 1
PELP1 SUCLG2 0 0 779 793 1 1
PELP1 STAT5A 0 0 127 224 1 1
PELP1 TEX10 878 900 956 999 1 1
PELP1 TTLL5 0 0 0 267 1 1
PELP1 PRPF40A 0 0 0 229 1 1
PELP1 PTK6 0 900 134 911 1 2
PELP1 MNDA 270 0 97 359 1 1
PELP1 LCK 0 0 0 315 1 1
PELP1 RPL10 128 0 124 278 1 1
PELP1 PSMD1 0 0 81 174 1 1
PELP1 MAX 0 900 0 900 1 2
PELP1 GRB2 0 900 78 903 1 1
PELP1 FOS 0 0 181 216 1 2
PELP1 BSX 0 0 0 150 1 1
PELP1 SVIL 0 0 81 181 1 1
PELP1 NCOA3 0 0 566 577 1 1
PELP1 PKN2 0 0 73 215 1 1
PELP1 EBNA1BP2 0 900 0 911 1 1
PELP1 EPAS1 0 800 0 800 1 2
PELP1 RPS21 0 0 92 155 1 1
PELP1 ENSG00000257767 0 0 0 202 1 1
PELP1 E2F1 0 0 134 165 1 2
PELP1 SRA1 0 0 95 153 1 1
PELP1 ADAM15 0 0 67 151 1 1
PELP1 YBX2 0 0 94 329 1 1
PELP1 TM9SF2 0 0 150 292 1 1
PELP1 CHAF1A 0 0 0 224 1 1
PELP1 SSB 0 0 62 161 1 1
PELP1 ZNF232 0 0 71 282 1 1
PELP1 CCDC170 0 0 295 295 1 1
PELP1 SRF 273 0 82 423 1 1
PELP1 CAV1 0 0 544 572 1 2
PELP1 STXBP1 0 0 54 153 1 1
PELP1 ASH2L 0 360 0 386 1 1
PELP1 CCNA2 0 0 170 169 1 1
PELP1 NCOA2 0 0 324 374 1 1
PELP1 MAOB 0 0 113 150 1 1
PELP1 NAP1L4 0 0 106 161 1 1
PELP1 PPAN 0 0 134 230 1 1
PELP1 TAF1 0 900 74 914 1 1
PELP1 FBL 282 0 0 333 1 2
PELP1 ACAD11 0 0 125 368 1 1
PELP1 TTLL4 0 0 379 501 1 1
PELP1 PLCG1 0 0 293 310 1 1
PELP1 HNRNPAB 0 0 95 202 1 1
PELP1 JUN 0 0 146 209 1 2
PELP1 CCT8 0 0 90 173 1 1
PELP1 PES1 0 600 0 662 1 1
PELP1 HNRNPH3 0 0 0 153 1 1
PELP1 CYP19A1 0 0 423 427 1 2
PELP1 GRIN2C 0 0 54 221 1 1
PELP1 SRD5A1 0 0 112 193 1 1
PELP1 MED1 0 0 171 175 1 1
PELP1 RBMX 0 0 67 195 1 1
PELP1 WDR5 270 900 139 945 1 1
PELP1 SOX2 270 0 67 289 1 2
PELP1 KANSL1 0 900 0 900 1 1
PELP1 KAT8 0 900 0 900 1 1
PELP1 PRPF40B 0 0 0 256 1 1
PELP1 PSMA2 0 0 81 155 1 1
PELP1 KRI1 0 0 0 199 1 1
PELP1 DAXX 0 0 170 169 1 1
PELP1 RANGAP1 0 0 74 165 1 1
PELP1 INTS5 0 0 136 215 1 1
PELP1 INO80B 0 0 0 234 1 1
PELP1 SETDB1 0 0 436 541 1 1
PELP1 HSP90AA1 0 0 122 160 1 2
PELP1 SLC9A3 0 0 0 158 1 1
PELP1 ESRRG 0 0 235 246 1 1
PELP1 ARPC5 0 0 86 179 1 1
PELP1 MMP9 0 0 143 158 1 2
PELP1 MAPK3 0 0 234 234 1 2
PELP1 ANLN 270 0 0 270 1 1
PELP1 BMS1 0 0 113 230 1 1
PELP1 KHSRP 0 0 52 175 1 1
PELP1 TAF6 0 900 0 903 1 1
PELP1 INTS1 0 0 0 169 1 1
PELP1 INS 0 0 147 169 1 2
PELP1 ENSG00000267140 0 900 0 900 1 1
PELP1 AK6 68 900 0 902 1 1
PELP1 CIT 270 0 0 296 1 1
PELP1 GPER1 0 0 469 472 1 2
PELP1 BCAR1 0 900 294 932 1 1
PELP1 HEATR6 0 0 341 356 1 1
PELP1 RPS2 239 0 0 288 1 1
PELP1 NOLC1 272 0 0 275 1 1
PELP1 SLC9A2 0 0 0 158 1 1
PELP1 HNRNPM 0 0 188 234 1 1
PELP1 TLR5 0 0 294 294 1 1
PELP1 KDM1A 270 0 808 854 1 2
PELP1 WDR74 0 0 126 167 1 1
PELP1 RBM14 0 0 171 222 1 1
PELP1 RPL24 0 0 92 170 1 1
PELP1 KIAA1324 0 0 134 325 1 1
PELP1 EXOSC3 0 0 81 176 1 1
PELP1 GNA12 0 0 90 168 1 1
PELP1 XRCC5 0 0 101 178 1 1
PELP1 MYH1 0 0 306 306 1 1
PELP1 GSK3B 0 0 74 229 1 2
PELP1 EIF3A 0 0 74 154 1 1
PELP1 ETV4 0 0 202 219 1 1
PELP1 GNRH1 0 0 294 294 1 1
PELP1 ANKRD49 0 0 167 251 1 1
PELP1 AR 462 900 983 999 1 2
PELP1 ALX3 0 0 96 342 1 1
PELP1 PDCD11 0 0 125 230 1 1
PELP1 HABP4 0 0 134 195 1 1
PELP1 SIRT7 270 0 0 278 1 2
PELP1 HDAC1 0 0 184 230 1 2
PELP1 ZEB1 0 0 140 200 1 2
PELP1 NOP14 0 0 0 165 1 1
PELP1 SF3B2 0 0 82 180 1 1
PELP1 SORBS2 0 0 74 153 1 1
PELP1 CHD8 0 900 0 900 1 1
PELP1 WDR61 0 0 140 216 1 1
PELP1 ESR2 196 0 668 727 1 1
PELP1 ACTG1 0 0 325 325 1 1
PELP1 RCL1 0 0 101 171 1 1
PELP1 CCNL1 0 0 139 229 1 1
PELP1 ROCK2 0 0 103 154 1 1
PELP1 RSL1D1 0 0 123 201 1 1
PELP1 IPCEF1 0 0 150 241 1 1
PELP1 KIF20A 270 0 0 270 1 1
PELP1 H2AFX 270 0 0 312 1 1
PELP1 NOC4L 0 0 0 207 1 1
PELP1 GMNN 0 0 48 150 1 1
PELP1 NPM1 382 0 70 435 1 1
PELP1 TAF1L 0 0 60 170 1 1
PELP1 PTK7 0 0 56 172 1 1
PELP1 SNAI1 0 0 154 189 1 1
PELP1 CDK7 0 0 117 154 1 1
PELP1 MATR3 0 0 61 177 1 1
PELP1 RRP1 0 0 0 168 1 1
PELP1 H3F3B 486 0 0 518 1 1
PELP1 ARVCF 0 0 175 195 1 1
PELP1 MYOC 0 0 54 153 1 1
PELP1 KDM4C 0 0 141 157 1 1
PELP1 PA2G4 0 0 103 215 1 1
PELP1 WAC 0 0 0 210 1 1
PELP1 SHC1 0 900 553 954 1 1
PELP1 ATM 0 0 123 217 1 2
PELP1 ARGLU1 0 0 108 212 1 1
PELP1 TBL3 0 0 0 168 1 1
PELP1 POLI 0 0 108 159 1 1
PELP1 MSH3 0 0 358 358 1 1
PELP1 NEURL4 0 0 138 617 1 1
PELP1 RTCA 0 0 150 223 1 1
PELP1 IPO5 270 0 0 298 1 1
PELP1 HCFC1 0 900 74 908 1 1
PELP1 NPM3 274 0 0 274 1 1
PELP1 LMNB2 0 0 45 154 1 1
PELP1 PRMT6 0 0 260 295 1 1
PELP1 EP300 270 900 583 967 1 2
PELP1 INO80C 0 900 0 900 1 1
PELP1 ZNF326 0 0 143 173 1 1
PELP1 PTEN 0 0 108 167 1 2
PELP1 RPL10A 0 0 93 172 1 1
PELP1 ERI1 0 0 107 462 1 1
PELP1 HERC4 0 0 113 168 1 1
PELP1 LRRC6 0 0 118 250 1 1
PELP1 VPS8 0 0 96 161 1 1
PELP1 HOOK1 0 0 95 187 1 1
PELP1 HIST1H3A 675 0 54 699 1 1
PELP1 ILF3 0 0 95 189 1 1
PELP1 FNDC3A 0 0 113 193 1 1
PELP1 RPS20 0 0 67 168 1 1
PELP1 SUGP2 0 0 161 167 1 1
PELP1 HCFC2 0 360 0 360 1 1
PELP1 CTR9 0 0 122 235 1 1
PELP1 AGO1 270 0 0 270 1 1
PELP1 MMS19 0 0 96 177 1 1
PELP1 NUDT1 0 0 74 156 1 1
PELP1 WDR18 870 800 707 992 1 1
PELP1 NEURL1 0 0 0 176 1 1
PELP1 MT-ND1 0 0 0 189 1 1
PELP1 ARL6IP5 0 0 96 152 1 1
PELP1 ACAD10 0 0 0 207 1 1
PELP1 PIK3R1 0 900 267 934 1 1
PELP1 PGRMC1 0 0 134 188 1 1
PELP1 FASN 0 0 398 430 1 2
PELP1 SOS2 0 0 67 151 1 1
PELP1 SYCE3 0 0 134 226 1 1
PELP1 EGF 0 0 218 296 1 2
PELP1 RNF19A 0 0 0 152 1 1
PELP1 ESR1 557 900 986 999 1 2
PELP1 RAC3 0 0 0 273 1 2
PELP1 WDR36 0 0 0 187 1 1
PELP1 NCL 0 0 123 184 1 2
PELP1 TEKT3 0 0 134 225 1 1
PELP1 OGG1 0 0 307 307 1 1
PELP1 NSD1 0 0 96 161 1 1
PELP1 SENP3 873 900 954 999 1 1
PELP1 H2AFY 0 0 248 248 1 1
PELP1 NANOG 0 0 43 183 1 2
PELP1 PYHIN1 486 0 113 557 1 1
PELP1 PCDH1 0 0 82 218 1 1
PELP1 ZC3H18 0 0 272 315 1 1
PELP1 DACH1 0 0 721 721 1 1
PELP1 NR2E1 0 0 90 196 1 1
PELP1 NEURL3 0 0 0 159 1 1
PELP1 EML3 0 0 64 166 1 1
PELP1 EXOSC2 0 0 115 215 1 1
PELP1 RUVBL1 272 900 0 929 1 1
PELP1 GPX1 0 0 396 396 1 1
PELP1 RRP9 0 0 0 189 1 1
PELP1 NR3C1 462 600 210 820 1 1
PELP1 CSK 0 0 150 181 1 1
PELP1 HNRNPA2B1 0 0 88 175 1 1
PELP1 P2RX7 0 0 73 171 1 2
PELP1 ZNF148 0 0 151 157 1 1
PELP1 PXN 0 0 146 238 1 1
PELP1 HIST2H3PS2 0 0 672 672 1 1
PELP1 TTLL12 0 0 54 193 1 1
PELP1 NFKBIB 0 0 72 231 1 1
PELP1 CDK11A 681 0 0 688 1 1
PELP1 UBR7 0 0 150 239 1 1
PELP1 CHD3 270 0 73 415 1 1
PELP1 TFF1 0 0 398 398 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0003723 Molecular Function RNA binding enables HDA
GO:0032183 Molecular Function SUMO binding enables IMP
GO:0003682 Molecular Function chromatin binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0071391 Biological Process cellular response to estrogen stimulus involved_in IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0006364 Biological Process rRNA processing involved_in IBA
GO:0071339 Cellular Component MLL1 complex part_of IDA
GO:0005737 Cellular Component cytoplasm located_in IEA
GO:0000791 Cellular Component euchromatin part_of IDA
GO:0005730 Cellular Component nucleolus located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus located_in IDA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Major pathway of rRNA processing in the nucleolus and cytosol Reactome R-HSA-6791226
rRNA processing Reactome R-HSA-72312
Signaling by PTK6 Reactome R-HSA-8848021
PTK6 Expression Reactome R-HSA-8849473
rRNA processing in the nucleus and cytosol Reactome R-HSA-8868773
Metabolism of RNA Reactome R-HSA-8953854
Signaling by Non-Receptor Tyrosine Kinases Reactome R-HSA-9006927
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_014389 3 mRNA transcript variant 1 NC_000017 Reference
NM_001278241 2 mRNA transcript variant 2 NC_000017 Reference