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BBC3

BCL2 binding component 3
General Information
Name BCL2 binding component 3
Alias
  • bcl-2-binding component 3
  • p53 up-regulated modulator of apoptosis
  • p53-upregulated modulator of apoptosis
Gene_family MicroRNA protein coding host genes|BCL2 homology region 3 (BH3) only
organism Homo sapiens
entrez_id 27113
location 19q13.32
transcript_count 7
exon_count 8
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
    Stringdb Bcl-2-binding component 3; Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity; BCL2 homology region 3 only
    nextProt Does not affect cell growth.
    nextProt Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
BBC3 BioGRID BCL2L13 GeneID BioGRID Negative Genetic
BBC3 BioGRID BNIP3 GeneID BioGRID Negative Genetic
BBC3 BioGRID BAD GeneID BioGRID Negative Genetic
BBC3 BioGRID FBXL20 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BBC3 BioGRID BAX GeneID BioGRID Affinity Capture-Western
BBC3 BioGRID CHCHD2 GeneID BioGRID Affinity Capture-MS
BBC3 BioGRID MCL1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Protein-peptide; Reconstituted Complex; Two-hybrid
BBC3 BioGRID BCL2L2 GeneID BioGRID Affinity Capture-MS
BBC3 BioGRID BCL2L1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide
BBC3 BioGRID BCL2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Protein-peptide
BBC3 BioGRID SREBF2 GeneID BioGRID Negative Genetic
BBC3 BioGRID LDLR GeneID BioGRID Negative Genetic
BBC3 BioGRID HSD17B13 GeneID BioGRID Two-hybrid
BBC3 BioGRID MYPOP GeneID BioGRID Two-hybrid
BBC3 BioGRID ZNF438 GeneID BioGRID Two-hybrid
BBC3 BioGRID UBASH3B GeneID BioGRID Two-hybrid
BBC3 BioGRID WDR5 GeneID BioGRID Two-hybrid
BBC3 BioGRID FHL5 GeneID BioGRID Two-hybrid
BBC3 BioGRID HGS GeneID BioGRID Two-hybrid
BBC3 BioGRID NDUFAB1 GeneID BioGRID Two-hybrid
BBC3 BioGRID NOL3 GeneID BioGRID Affinity Capture-Western
BBC3 BioGRID FOXO3 GeneID BioGRID Co-localization
BBC3 BioGRID CHUK GeneID BioGRID Affinity Capture-Western; Biochemical Activity
BBC3 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western
BBC3 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
BBC3 BioGRID TNIP2 GeneID BioGRID Affinity Capture-RNA
BBC3 BioGRID TP53 GeneID BioGRID Co-localization
BBC3 BioGRID SET GeneID BioGRID Co-localization
BBC3 BioGRID H3-3A GeneID BioGRID Co-localization
BBC3 BioGRID EP300 GeneID BioGRID Co-localization
BBC3 BioGRID CREBBP GeneID BioGRID Co-localization
BBC3 BioGRID EGFR GeneID BioGRID Affinity Capture-Western
BBC3 BioGRID BCL2A1 GeneID BioGRID Protein-peptide
BBC3 BioGRID ALB GeneID BioGRID Affinity Capture-MS
BBC3 Protein MCL1 GeneID HPRD
BBC3 Protein BCL2L2 GeneID HPRD
BBC3 Protein BCL2A1 GeneID HPRD
BBC3 Protein BAX GeneID HPRD
BBC3 Protein BCL2L1 GeneID HPRD
BBC3 Protein BCL2 GeneID HPRD
BBC3 Protein BCL2A1 GeneID BIND Puma interacts with A1. This interaction was modelled on a demonstrated interaction between human Puma and mouse A1.
BBC3 Protein BNC1 GeneID BIND Puma interacts with Mcl-1. This interaction was modelled on a demonstrated interaction between human Puma and mouse Mcl-1.
BBC3 Protein BCL2L1 GeneID BIND Puma interacts with Bcl-XL.
BBC3 Protein BCL2 GeneID BIND Puma interacts with Bcl-2.
BBC3 Protein BCL2L2 GeneID BIND Puma interacts with Bcl-w.
BBC3 Protein BCL2L1 GeneID BIND PUMA interacts with Bcl-xL.
BBC3 Protein BCL2 GeneID BIND PUMA interacts with Bcl-2.
BBC3 Protein BAX GeneID BIND Bax interacts with PUMA.
BBC3 Protein MCL1 GeneID BIND Mcl-1 interacts with Puma. This interaction was modelled on a demonstrated interaction between Mcl-1 from an unspecified species and human Puma.
BBC3 Protein BCL2L1 GeneID BIND Bcl-XL interacts with Puma. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Puma.
BBC3 Protein BCL2 GeneID BIND PUMA-beta interacts with Bcl-2.
BBC3 Protein BCL2 GeneID BIND PUMA-alpha interacts with Bcl-2.
StringDB
A B experiments database textmining combined score hadb nhadb
BBC3 TRAF4 0 0 156 181 1 1
BBC3 PIDD1 0 0 384 401 1 1
BBC3 HIST1H4F 0 0 164 163 1 1
BBC3 SRC 0 0 150 181 1 2
BBC3 NOTCH1 0 0 224 252 1 2
BBC3 SCO2 0 0 183 202 1 1
BBC3 MTOR 0 0 294 294 1 2
BBC3 RAD51 0 0 213 213 1 2
BBC3 FOXO3 273 900 426 954 1 2
BBC3 DCTN2 0 0 306 306 1 1
BBC3 E2F2 0 0 174 173 1 1
BBC3 PIK3C3 0 0 181 181 1 2
BBC3 TP53INP1 0 0 451 451 1 2
BBC3 EIF2AK3 0 0 400 400 1 2
BBC3 IL6 0 0 232 231 1 2
BBC3 ENDOG 0 0 334 358 1 1
BBC3 BCL2L2-PABPN1 0 0 560 560 1 1
BBC3 BIRC6 0 0 160 159 1 1
BBC3 BNIP1 0 0 204 204 1 2
BBC3 TNFRSF1A 0 0 262 262 1 1
BBC3 CDKN3 0 0 261 261 1 1
BBC3 EIF2S1 0 0 282 282 1 2
BBC3 MT1E 0 0 230 229 1 1
BBC3 HIF1A 0 0 245 244 1 2
BBC3 SIRT5 0 0 164 163 1 1
BBC3 PRRC2A 0 0 291 308 1 1
BBC3 SP1 0 0 167 167 1 2
BBC3 IL1B 0 0 212 212 1 2
BBC3 TCHP 0 0 383 382 1 1
BBC3 CXCL8 0 0 161 161 1 2
BBC3 HIST1H4D 0 0 164 163 1 1
BBC3 HMOX1 0 0 181 204 1 2
BBC3 CTNNB1 0 0 264 264 1 2
BBC3 USP7 0 0 322 321 1 1
BBC3 MAP1LC3A 270 0 82 301 1 2
BBC3 HRAS 0 0 265 283 1 2
BBC3 CDK2 0 0 261 261 1 2
BBC3 CDKN1B 0 0 322 321 1 2
BBC3 EGR1 0 0 170 169 1 2
BBC3 RIPK3 0 0 182 181 1 2
BBC3 PDCD7 0 0 184 183 1 1
BBC3 TSC2 0 0 171 171 1 2
BBC3 PPM1D 0 0 342 342 1 1
BBC3 VDAC1 0 0 182 181 1 2
BBC3 BNIP3L 0 0 235 235 1 2
BBC3 CAPRIN2 0 0 178 177 1 1
BBC3 ATF4 0 0 256 256 1 2
BBC3 CASP6 0 0 270 270 1 1
BBC3 FAS 0 0 369 369 1 2
BBC3 RPL13 0 0 153 177 1 1
BBC3 ZMAT3 0 0 469 469 1 1
BBC3 RELA 0 0 181 204 1 2
BBC3 AKT1 0 0 420 436 1 2
BBC3 BCL2L1 894 900 872 998 1 2
BBC3 HIST1H4C 0 0 164 163 1 1
BBC3 PPP1R13L 0 0 211 211 1 1
BBC3 TLR4 0 0 155 154 1 2
BBC3 ASNS 0 0 184 183 1 1
BBC3 XIAP 0 0 391 390 1 2
BBC3 PPP2R4 0 0 162 161 1 1
BBC3 BNIPL 0 0 157 156 1 1
BBC3 TNFRSF25 0 0 170 169 1 1
BBC3 GAPDH 0 0 370 370 1 2
BBC3 DROSHA 0 0 228 227 1 1
BBC3 TRIAP1 0 0 273 398 1 1
BBC3 ATF6 0 0 324 323 1 2
BBC3 IKBKB 0 0 151 150 1 2
BBC3 ABL1 0 0 202 202 1 1
BBC3 HIST4H4 0 0 164 163 1 1
BBC3 MAP2K7 0 0 293 293 1 1
BBC3 BIRC8 0 0 218 218 1 1
BBC3 USP25 0 0 439 439 1 1
BBC3 CREBBP 273 0 123 335 1 1
BBC3 FOXO4 0 0 141 172 1 1
BBC3 DGCR8 0 0 180 179 1 1
BBC3 BCL6 0 0 155 154 1 1
BBC3 BIRC2 0 0 246 245 1 1
BBC3 BIRC5 0 0 282 282 1 2
BBC3 SIRT4 0 0 167 167 1 1
BBC3 CCNG2 0 0 211 211 1 1
BBC3 CREB1 0 0 167 167 1 2
BBC3 ZNF761 0 0 286 286 1 1
BBC3 ANXA5 0 0 454 454 1 2
BBC3 CCNB1 0 0 261 261 1 1
BBC3 FOXF2 0 0 155 154 1 1
BBC3 RPS27L 0 0 310 309 1 1
BBC3 ERBB2 0 0 380 385 1 2
BBC3 MGMT 0 0 167 167 1 2
BBC3 PERP 0 0 294 294 1 1
BBC3 SIRT2 0 0 161 161 1 2
BBC3 PLK1 0 0 144 168 1 2
BBC3 CCNE2 0 0 351 351 1 1
BBC3 BCL2A1 696 900 468 982 1 1
BBC3 HIST1H4L 0 0 164 163 1 1
BBC3 SMAD4 0 0 161 161 1 2
BBC3 NOL3 270 0 90 307 1 1
BBC3 BMF 0 0 606 615 1 1
BBC3 HOXB3 0 0 307 307 1 1
BBC3 RELB 0 0 173 245 1 2
BBC3 DRAM1 0 0 406 448 1 2
BBC3 NUPR1 0 0 218 218 1 2
BBC3 ZNF697 0 0 167 167 1 1
BBC3 CASP10 0 0 174 173 1 1
BBC3 MOAP1 0 0 330 330 1 1
BBC3 IER5 0 0 279 305 1 1
BBC3 HIST1H4H 0 0 164 163 1 1
BBC3 EZH1 0 0 398 398 1 1
BBC3 NFE2L2 0 0 184 183 1 2
BBC3 SOCS1 0 0 123 162 1 1
BBC3 VWCE 0 0 213 213 1 1
BBC3 PPP1R13B 0 900 193 915 1 1
BBC3 IGF1 0 0 189 189 1 2
BBC3 GET4 0 0 390 390 1 1
BBC3 GLTSCR2 0 0 123 153 1 1
BBC3 BRCA1 0 0 285 284 1 2
BBC3 SLC25A25 0 0 160 159 1 1
BBC3 ATF3 0 0 263 284 1 2
BBC3 CHAC1 0 0 261 261 1 1
BBC3 PHLDA3 0 0 370 370 1 1
BBC3 GADD45A 0 0 561 571 1 1
BBC3 PPIF 0 0 167 167 1 1
BBC3 RPS19BP1 0 0 294 294 1 1
BBC3 CDKN2D 0 0 142 160 1 1
BBC3 AEN 0 0 321 337 1 1
BBC3 CASP2 0 0 358 358 1 1
BBC3 MYC 0 0 401 400 1 2
BBC3 ASNA1 0 0 415 414 1 1
BBC3 LIG4 0 0 108 308 1 1
BBC3 IGF1R 0 0 235 235 1 2
BBC3 C22orf29 0 0 681 681 1 1
BBC3 TNF 0 0 310 309 1 2
BBC3 PPP1R15A 0 0 324 343 1 2
BBC3 GLS2 0 0 189 189 1 1
BBC3 LRP5L 0 0 135 156 1 1
BBC3 CES1 0 0 327 327 1 1
BBC3 BAK1 0 0 608 622 1 2
BBC3 SETD8 0 0 389 388 1 1
BBC3 BCL2 873 900 342 990 1 2
BBC3 HIST2H4B 0 0 164 163 1 1
BBC3 BRD7 270 0 46 273 1 1
BBC3 APAF1 0 0 561 561 1 2
BBC3 DDIT4 0 0 217 239 1 2
BBC3 HUWE1 0 0 203 203 1 1
BBC3 BAG6 0 0 309 326 1 1
BBC3 NR4A1 0 0 155 154 1 2
BBC3 TP53I3 0 0 493 504 1 1
BBC3 DFFA 0 0 193 193 1 1
BBC3 PPARD 0 0 70 563 1 1
BBC3 ERN1 0 0 325 325 1 2
BBC3 CAT 0 0 205 205 1 2
BBC3 STAT3 0 0 255 254 1 2
BBC3 CCNE1 0 0 165 165 1 1
BBC3 HRK 0 0 633 633 1 1
BBC3 EZH2 0 0 164 163 1 2
BBC3 TXN 0 0 161 161 1 1
BBC3 TP53 494 900 710 984 1 2
BBC3 MDM2 0 0 611 611 1 2
BBC3 UBL4A 0 0 357 370 1 1
BBC3 FDXR 0 0 561 599 1 1
BBC3 SESN1 0 0 460 485 1 1
BBC3 HIST1H4B 0 0 164 163 1 1
BBC3 FADD 0 0 342 361 1 2
BBC3 CDK1 0 0 261 261 1 2
BBC3 PRKDC 0 0 220 220 1 2
BBC3 SERPINE1 0 0 162 161 1 1
BBC3 SLC2A1 0 0 151 150 1 2
BBC3 CDK4 0 0 248 248 1 2
BBC3 EGFR 270 0 475 600 1 2
BBC3 CFLAR 0 0 309 309 1 2
BBC3 HIST1H4I 0 0 164 163 1 1
BBC3 BAD 0 0 518 518 1 2
BBC3 RRM2B 0 0 253 252 1 1
BBC3 DDB2 0 0 469 469 1 1
BBC3 RPRM 0 0 193 193 1 1
BBC3 CCND1 0 0 323 323 1 2
BBC3 BCL2L2 733 0 605 890 1 1
BBC3 DDIT3 0 900 503 948 1 2
BBC3 ATR 0 0 215 215 1 2
BBC3 FAM96A 0 0 167 167 1 1
BBC3 MAP1A 0 0 241 240 1 2
BBC3 CRADD 0 0 167 167 1 1
BBC3 HIST1H4E 0 0 164 163 1 1
BBC3 SIRT6 0 0 160 207 1 2
BBC3 MDM4 0 0 318 317 1 1
BBC3 CDK6 0 0 233 232 1 2
BBC3 TNFRSF10C 0 0 141 327 1 1
BBC3 BCL2L13 0 0 193 193 1 2
BBC3 IGF2 0 0 182 192 1 1
BBC3 CDH1 0 0 231 230 1 2
BBC3 BCL2L10 0 0 413 412 1 1
BBC3 ATM 0 0 465 465 1 2
BBC3 SNAI1 0 0 201 220 1 1
BBC3 H3F3B 273 0 0 273 1 1
BBC3 NR3C2 0 0 0 303 1 1
BBC3 ATG7 0 0 218 218 1 2
BBC3 H2AFX 0 0 282 302 1 1
BBC3 TRADD 0 0 219 248 1 1
BBC3 GDF15 0 0 334 355 1 1
BBC3 BTG2 0 0 394 409 1 1
BBC3 DNM1L 0 0 241 240 1 2
BBC3 SNAI2 0 0 270 270 1 1
BBC3 ALB 0 0 181 181 1 2
BBC3 CASP8 0 0 501 501 1 2
BBC3 VEGFA 0 0 216 216 1 2
BBC3 CASP7 0 0 342 342 1 1
BBC3 USP28 0 0 501 501 1 1
BBC3 PTEN 0 0 414 414 1 2
BBC3 TIMP3 0 0 181 181 1 1
BBC3 EP300 273 0 212 402 1 2
BBC3 KAT5 0 0 181 181 1 1
BBC3 HIST1H4K 0 0 164 163 1 1
BBC3 TP53BP2 0 900 267 923 1 2
BBC3 BAG1 0 0 134 188 1 2
BBC3 E2F3 0 0 194 194 1 1
BBC3 HIST1H4A 0 0 164 163 1 1
BBC3 MAPK10 0 0 164 163 1 2
BBC3 C9orf84 0 0 175 175 1 1
BBC3 BIRC3 0 0 265 270 1 1
BBC3 COMMD3-BMI1 0 0 204 204 1 1
BBC3 TNFRSF10A 0 0 324 323 1 1
BBC3 KIT 0 0 166 165 1 2
BBC3 ERO1L 0 0 294 294 1 1
BBC3 TP53AIP1 0 0 454 454 1 1
BBC3 C12orf5 0 0 361 361 1 1
BBC3 MAP3K5 0 0 255 254 1 1
BBC3 CASP9 0 0 560 560 1 2
BBC3 ESR1 0 0 240 240 1 2
BBC3 MAPK9 0 0 231 230 1 2
BBC3 CYCS 0 0 610 610 1 2
BBC3 PLK2 0 0 270 290 1 1
BBC3 CHEK2 0 0 324 323 1 1
BBC3 GADD45B 0 0 234 256 1 1
BBC3 CTF1 0 0 291 290 1 1
BBC3 EGF 0 0 162 161 1 2
BBC3 SETD7 0 0 326 325 1 1
BBC3 TP53BP1 0 0 242 241 1 1
BBC3 MCL1 879 900 827 997 1 2
BBC3 SIRT1 0 0 318 317 1 2
BBC3 XBP1 0 0 269 269 1 2
BBC3 YAP1 0 0 307 307 1 2
BBC3 HSPA4 0 0 210 210 1 1
BBC3 HIPK2 0 0 240 239 1 2
BBC3 TP63 0 900 154 911 1 2
BBC3 CDKN1C 0 0 234 234 1 1
BBC3 DICER1 0 0 234 234 1 1
BBC3 PDCD4 0 0 216 216 1 2
BBC3 XPO5 0 0 174 173 1 1
BBC3 HSPB3 0 0 167 167 1 1
BBC3 HTATIP2 0 0 173 173 1 1
BBC3 ATG5 0 0 245 244 1 2
BBC3 BCL2L14 0 0 284 284 1 1
BBC3 PPARA 0 0 95 295 1 2
BBC3 TNS1 0 0 160 159 1 1
BBC3 DFFB 0 0 210 210 1 1
BBC3 MAP1LC3B 0 0 181 181 1 2
BBC3 HIST2H3PS2 0 0 181 181 1 1
BBC3 DIABLO 0 0 423 422 1 2
BBC3 SESN2 0 0 358 402 1 2
BBC3 HSPB1 0 0 151 150 1 2
BBC3 IKBKG 0 0 112 154 1 1
BBC3 ZNF79 0 0 181 198 1 1
BBC3 MAPK8 0 0 283 282 1 2
BBC3 E4F1 0 0 358 382 1 1
BBC3 PLK3 0 0 299 377 1 1
BBC3 ULK1 0 0 210 234 1 2
BBC3 HSPA5 0 0 307 307 1 2
BBC3 IGFBP3 0 0 171 171 1 2
BBC3 E2F1 0 900 161 914 1 2
BBC3 BIK 0 0 605 605 1 2
BBC3 KRAS 0 0 233 232 1 2
BBC3 FOXO1 0 900 193 915 1 2
BBC3 SOD2 0 0 242 241 1 2
BBC3 MMP2 0 0 160 159 1 2
BBC3 FOS 0 0 171 171 1 2
BBC3 FASLG 0 0 391 390 1 1
BBC3 TICAM1 0 0 107 157 1 2
BBC3 SOCS3 0 0 160 159 1 1
BBC3 CCDC9 0 0 161 191 1 1
BBC3 CDC25C 0 0 182 181 1 2
BBC3 STAT5A 0 0 171 171 1 1
BBC3 BMI1 0 0 211 211 1 1
BBC3 BIRC7 0 0 166 165 1 1
BBC3 TNIP2 118 0 0 150 1 1
BBC3 BCL2L15 0 0 257 256 1 1
BBC3 INTS6 0 0 255 254 1 1
BBC3 BCL2L11 0 800 707 938 1 2
BBC3 CDC25A 0 0 224 224 1 1
BBC3 JUN 0 0 392 392 1 2
BBC3 BECN1 0 0 358 358 1 2
BBC3 ABCB1 0 0 158 157 1 2
BBC3 IGFL3 0 0 181 181 1 1
BBC3 DNTT 0 0 270 270 1 1
BBC3 CHEK1 0 0 287 286 1 2
BBC3 CCNA2 0 0 164 163 1 1
BBC3 CASP1 0 0 173 173 1 2
BBC3 ABCC1 0 0 170 169 1 1
BBC3 MAPK11 0 0 143 174 1 1
BBC3 PMAIP1 0 800 759 949 1 2
BBC3 TNFSF10 0 0 374 374 1 2
BBC3 BOK 0 0 503 503 1 1
BBC3 FUT8 0 0 73 325 1 1
BBC3 STUB1 0 0 134 159 1 2
BBC3 TNFRSF10B 0 0 504 518 1 2
BBC3 INS 0 0 216 216 1 2
BBC3 ACTB 0 0 373 373 1 2
BBC3 ATG12 0 0 195 195 1 2
BBC3 HIST1H4J 0 0 164 163 1 1
BBC3 EDA2R 0 0 181 195 1 1
BBC3 TFDP1 0 900 0 900 1 1
BBC3 BNIP3 0 0 340 340 1 2
BBC3 SQSTM1 270 0 171 368 1 2
BBC3 KEAP1 0 0 170 169 1 2
BBC3 MAPK3 0 0 195 195 1 2
BBC3 SIRT3 0 0 154 153 1 2
BBC3 ARL2BP 0 0 371 371 1 1
BBC3 TRIB3 0 0 241 268 1 2
BBC3 HSP90AA1 0 0 170 169 1 2
BBC3 ZSCAN20 0 0 235 235 1 1
BBC3 TP73 0 900 293 926 1 2
BBC3 DAXX 0 0 167 167 1 1
BBC3 COX4I1 0 0 181 181 1 1
BBC3 CASP3 0 0 602 602 1 2
BBC3 SET 273 0 0 273 1 1
BBC3 PTGS2 0 0 157 156 1 2
BBC3 HTRA2 0 0 261 261 1 1
BBC3 PHPT1 0 0 370 370 1 1
BBC3 CEBPB 0 0 125 185 1 2
BBC3 TOMM22 0 0 204 204 1 1
BBC3 RIPK1 0 0 213 213 1 2
BBC3 SIRT7 0 0 166 165 1 2
BBC3 IQCB1 0 0 388 388 1 1
BBC3 ZEB1 0 0 167 167 1 2
BBC3 HDAC1 0 0 151 150 1 2
BBC3 SFN 0 0 282 282 1 2
BBC3 BID 0 800 616 919 1 2
BBC3 CASP4 0 0 166 165 1 2
BBC3 PARP1 0 0 294 294 1 2
BBC3 CDKN2A 0 0 346 345 1 2
BBC3 CDKN1A 0 0 605 624 1 2
BBC3 CCNG1 0 0 395 394 1 1
BBC3 BAX 213 0 666 739 1 2
BBC3 ZNF302 0 0 155 154 1 1
BBC3 FAM212B 0 0 170 169 1 1
BBC3 KIFAP3 0 0 260 260 1 1
BBC3 CHUK 270 0 141 346 1 1
BBC3 HIST2H4A 0 0 164 163 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0051117 Molecular Function ATPase binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IBA
GO:0006915 Biological Process apoptotic process involved_in IMP
GO:0097194 Biological Process execution phase of apoptosis involved_in IBA
GO:0070059 Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress involved_in IBA
GO:2001244 Biological Process positive regulation of intrinsic apoptotic signaling pathway involved_in ISS
GO:1900740 Biological Process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway involved_in IBA
GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in IBA
GO:0001836 Biological Process release of cytochrome c from mitochondria involved_in IBA
GO:0005764 Cellular Component lysosome colocalizes_with IDA
GO:0005739 Cellular Component mitochondrion is_active_in IBA
GO:0005739 Cellular Component mitochondrion located_in TAS
Pathways
Name DB ID
Apoptosis Reactome R-HSA-109581
Intrinsic Pathway for Apoptosis Reactome R-HSA-109606
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Reactome R-HSA-111453
Activation of BH3-only proteins Reactome R-HSA-114452
Activation of PUMA and translocation to mitochondria Reactome R-HSA-139915
Generic Transcription Pathway Reactome R-HSA-212436
Transcriptional Regulation by TP53 Reactome R-HSA-3700989
Programmed Cell Death Reactome R-HSA-5357801
TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome R-HSA-6803204
RNA Polymerase II Transcription Reactome R-HSA-73857
Gene expression (Transcription) Reactome R-HSA-74160
FOXO-mediated transcription Reactome R-HSA-9614085
FOXO-mediated transcription of cell death genes Reactome R-HSA-9614657
Integrated cancer pathway (WP1971) WikiPathways WP1971_r117762
p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
Chromosomal and microsatellite instability in colorectal cancer (WP4216) WikiPathways WP4216_r123363
Measles virus infection (WP4630) WikiPathways WP4630_r123414
miRNA regulation of p53 pathway in prostate cancer (WP3982) WikiPathways WP3982_r108115
DNA damage response (only ATM dependent) (WP710) WikiPathways WP710_r116542
Unfolded protein response (WP4925) WikiPathways WP4925_r123438
Host-pathogen interaction of human coronaviruses - apoptosis (WP4864) WikiPathways WP4864_r124634
DNA damage response (WP707) WikiPathways WP707_r124174
TP53 network (WP1742) WikiPathways WP1742_r116592
Apoptosis (WP254) WikiPathways WP254_r118382
Nonalcoholic fatty liver disease (WP4396) WikiPathways WP4396_r123350
Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
Photodynamic therapy-induced unfolded protein response (WP3613) WikiPathways WP3613_r106539
miRNA regulation of DNA damage response (WP1530) WikiPathways WP1530_r124175
Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_006723141 4 mRNA transcript variant X3 NC_000019 Reference
NM_001127242 3 mRNA transcript variant 3 NC_000019 Reference
NM_001127241 3 mRNA transcript variant 2 NC_000019 Reference
NM_001127240 3 mRNA transcript variant 1 NC_000019 Reference
XM_047438606 1 mRNA transcript variant X1 NC_000019 Reference
NM_014417 5 mRNA transcript variant 4 NC_000019 Reference
XM_011526722 3 mRNA transcript variant X2 NC_000019 Reference