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GLA

galactosidase alpha
General Information
Name galactosidase alpha
Alias
  • alpha-galactosidase A
  • agalsidase alfa
  • alpha-D-galactosidase A
  • alpha-D-galactoside galactohydrolase 1
  • alpha-gal A
  • galactosylgalactosylglucosylceramidase GLA
  • melibiase
Gene_family Galactosidases alpha
organism Homo sapiens
entrez_id 2717
location Xq22.1
transcript_count 8
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]
    Stringdb Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family
    nextProt Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
GLA BioGRID ORF10 GeneID BioGRID Proximity Label-MS
GLA BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
GLA BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
GLA BioGRID ARHGAP24 GeneID BioGRID Affinity Capture-MS
GLA BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
GLA BioGRID NTRK3 GeneID BioGRID Affinity Capture-MS
GLA BioGRID MET GeneID BioGRID Proximity Label-MS
GLA BioGRID INSR GeneID BioGRID Affinity Capture-MS
GLA BioGRID IGF1R GeneID BioGRID Affinity Capture-MS
GLA BioGRID TYRO3 GeneID BioGRID Affinity Capture-MS
GLA BioGRID PRKN GeneID BioGRID Affinity Capture-MS
GLA BioGRID DDX17 GeneID BioGRID Co-fractionation
GLA BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
GLA BioGRID RNPEP GeneID BioGRID Co-fractionation
GLA BioGRID orf3 GeneID BioGRID Affinity Capture-MS
GLA BioGRID G3BP2 GeneID BioGRID Affinity Capture-MS
GLA BioGRID CANX GeneID BioGRID Affinity Capture-MS
GLA BioGRID TMEM106B GeneID BioGRID Proximity Label-MS
GLA BioGRID TMPRSS4 GeneID BioGRID Affinity Capture-MS
GLA BioGRID TMPRSS2 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
GLA BioGRID DPP4 GeneID BioGRID Affinity Capture-MS
GLA BioGRID TMPRSS11B GeneID BioGRID Affinity Capture-MS
GLA BioGRID RDH14 GeneID BioGRID Affinity Capture-MS
GLA BioGRID RC3H2 GeneID BioGRID Affinity Capture-MS
GLA BioGRID NPRL2 GeneID BioGRID Affinity Capture-MS
GLA BioGRID DEPDC5 GeneID BioGRID Affinity Capture-MS
GLA BioGRID NPRL3 GeneID BioGRID Affinity Capture-MS
GLA BioGRID HLA-DRA GeneID BioGRID Affinity Capture-MS
GLA BioGRID ALG11 GeneID BioGRID Affinity Capture-MS
GLA BioGRID TMEM205 GeneID BioGRID Affinity Capture-MS
GLA BioGRID RC3H1 GeneID BioGRID Affinity Capture-MS
GLA BioGRID MARCHF4 GeneID BioGRID Affinity Capture-MS
GLA BioGRID FBXO6 GeneID BioGRID Affinity Capture-MS
GLA BioGRID SEC61B GeneID BioGRID Proximity Label-MS
GLA BioGRID OGT GeneID BioGRID Reconstituted Complex
GLA BioGRID FAM20C GeneID BioGRID Affinity Capture-MS
GLA BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
GLA BioGRID LRRK2 GeneID BioGRID Affinity Capture-MS
GLA BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
GLA BioGRID LAMP1 GeneID BioGRID Affinity Capture-MS
GLA BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
GLA BioGRID RIPK4 GeneID BioGRID Affinity Capture-MS
GLA BioGRID ORF47 GeneID BioGRID Affinity Capture-MS
GLA BioGRID CNOT6 GeneID BioGRID Affinity Capture-MS
GLA BioGRID CNOT11 GeneID BioGRID Affinity Capture-MS
GLA BioGRID CNOT2 GeneID BioGRID Affinity Capture-MS
GLA BioGRID PTPN18 GeneID BioGRID Affinity Capture-MS
GLA BioGRID ZNF622 GeneID BioGRID Co-fractionation
GLA BioGRID CNDP2 GeneID BioGRID Co-fractionation
GLA BioGRID MAT2B GeneID BioGRID Co-fractionation
GLA BioGRID EIF4H GeneID BioGRID Co-fractionation
GLA BioGRID PGD GeneID BioGRID Co-fractionation
GLA BioGRID GNS GeneID BioGRID Co-fractionation
GLA BioGRID GBP2 GeneID BioGRID Co-fractionation
GLA BioGRID G6PD GeneID BioGRID Co-fractionation
GLA BioGRID EIF5 GeneID BioGRID Co-fractionation
GLA BioGRID CAPN1 GeneID BioGRID Co-fractionation
GLA BioGRID ALDH7A1 GeneID BioGRID Co-fractionation
GLA BioGRID TERT GeneID BioGRID Two-hybrid
GLA BioGRID OTUD4 GeneID BioGRID Affinity Capture-MS
GLA Protein GLA GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
GLA FAM26D 0 0 0 177 1 1
GLA VDAC1 0 0 0 181 1 2
GLA PIK3C2A 0 0 181 181 1 1
GLA DDB1 0 0 0 202 1 1
GLA LGALS9C 0 0 0 154 1 1
GLA SPINT2 0 0 538 538 1 1
GLA ZBTB7C 0 0 157 156 1 1
GLA ALG2 0 0 0 207 1 1
GLA MAP3K6 0 0 158 157 1 1
GLA EIF4H 244 0 0 243 1 1
GLA PGA3 0 0 0 222 1 1
GLA OXCT1 0 0 0 260 1 1
GLA PDLIM3 0 0 0 173 1 1
GLA PDE9A 0 0 0 188 1 1
GLA MDH2 0 0 46 155 1 1
GLA ANPEP 0 0 95 209 1 1
GLA LDHB 0 0 120 211 1 1
GLA SKP1 0 0 809 814 1 2
GLA POC1B-GALNT4 0 0 171 177 1 1
GLA CUBN 0 0 96 172 1 1
GLA FLT1 0 0 81 176 1 1
GLA HEXA 0 900 284 956 1 1
GLA NAGLU 0 0 200 272 1 1
GLA LGALS3 0 0 96 201 1 2
GLA MAN1C1 0 0 0 205 1 1
GLA DNAJB11 0 0 0 151 1 1
GLA TNPO2 0 0 0 202 1 1
GLA SYNPO2L 0 0 0 173 1 1
GLA NEXN 0 0 0 187 1 1
GLA VDAC3 0 0 0 181 1 1
GLA DNAJC5 0 0 86 186 1 1
GLA PCSK9 0 0 134 166 1 1
GLA IL25 0 0 0 169 1 1
GLA F2 0 0 90 185 1 1
GLA PODXL 0 0 193 193 1 1
GLA ADA 0 0 96 164 1 1
GLA TMED9 0 0 0 158 1 1
GLA TLR9 0 0 134 223 1 2
GLA NEU4 0 900 0 906 1 1
GLA FUCA1 0 0 299 609 1 1
GLA MGAM 0 900 605 965 1 1
GLA CLCA1 0 0 44 217 1 1
GLA CD1D 0 0 683 683 1 1
GLA IGF2R 270 0 134 340 1 1
GLA GLYATL3 0 0 92 283 1 1
GLA ERBB2 0 0 183 213 1 2
GLA TCAP 0 0 181 232 1 1
GLA ADH4 0 0 0 240 1 1
GLA SDR16C5 0 0 125 152 1 1
GLA TOR4A 0 0 244 243 1 1
GLA PDLIM2 0 0 0 173 1 1
GLA LGALS9B 0 0 0 154 1 1
GLA SLCO1A2 0 0 0 814 1 1
GLA TXNDC15 0 0 0 214 1 1
GLA ENSG00000248235 0 0 0 173 1 1
GLA ALOX5AP 0 0 205 205 1 1
GLA SCN5A 0 0 141 204 1 1
GLA SCGB2A1 0 0 193 193 1 1
GLA INSL5 0 0 69 164 1 1
GLA CST3 0 0 281 281 1 1
GLA GRIK1 0 0 500 499 1 1
GLA CAPN1 129 0 0 183 1 2
GLA GBP2 244 0 0 254 1 1
GLA SCN9A 0 0 161 161 1 1
GLA CD4 0 0 181 203 1 2
GLA ATP2A3 0 0 0 635 1 1
GLA ALDH7A1 129 0 0 203 1 1
GLA IFI30 0 0 0 150 1 1
GLA PGM5 0 0 0 165 1 1
GLA IGBP1 0 0 87 251 1 1
GLA MDH1 0 0 0 216 1 1
GLA PAH 0 0 211 322 1 1
GLA XIRP2 0 0 0 216 1 1
GLA NMB 0 0 103 299 1 1
GLA XYLB 0 0 167 176 1 1
GLA LCT 0 900 0 906 1 1
GLA TNF 0 0 150 211 1 2
GLA PDLIM5 0 0 0 173 1 1
GLA C6orf47 0 0 0 349 1 1
GLA PGM1 0 0 49 171 1 1
GLA ITPA 0 0 89 351 1 1
GLA PGK2 0 0 397 396 1 1
GLA IFI35 0 0 0 269 1 1
GLA CNOT6 251 0 0 250 1 1
GLA THBS2 0 0 81 179 1 1
GLA RNF41 0 0 0 189 1 1
GLA APOB 0 0 327 327 1 2
GLA APOL1 0 0 193 193 1 2
GLA TNNT2 0 0 391 390 1 1
GLA ATP12A 0 0 174 180 1 1
GLA TFRC 0 0 380 380 1 1
GLA CD63 0 0 100 338 1 2
GLA CD2AP 0 0 125 150 1 1
GLA SH3GL3 0 0 0 159 1 1
GLA ZNF22 0 0 52 215 1 1
GLA ADH5 0 0 164 163 1 1
GLA PDLIM7 0 0 0 173 1 1
GLA MYL2 0 0 241 271 1 1
GLA ATP2B2 0 0 0 539 1 1
GLA CALCB 0 0 67 271 1 1
GLA PPT2 0 0 0 170 1 1
GLA NOS3 0 0 431 431 1 2
GLA HEXB 0 900 261 956 1 1
GLA IDUA 0 0 607 607 1 1
GLA SCG3 0 0 134 369 1 1
GLA STX8 0 0 0 161 1 2
GLA ADRB2 0 0 166 165 1 1
GLA PGC 0 0 125 231 1 1
GLA GALM 0 900 181 927 1 1
GLA MYOZ2 0 0 194 194 1 1
GLA LIPA 0 0 341 355 1 1
GLA OSBPL10 0 0 0 155 1 1
GLA ENSG00000264813 0 0 505 505 1 1
GLA AGPAT3 0 0 0 158 1 1
GLA CANX 114 0 175 260 1 2
GLA ZC3H12D 0 0 234 234 1 1
GLA NPHS2 0 0 161 161 1 2
GLA GLB1L 0 0 0 441 1 1
GLA ZNF334 0 0 161 161 1 1
GLA GBA 0 0 635 651 1 1
GLA A3GALT2 0 0 517 537 1 1
GLA ATP2A2 0 0 0 456 1 1
GLA CHIT1 0 0 310 338 1 1
GLA RPA1 0 0 510 510 1 1
GLA GPAM 0 0 0 171 1 1
GLA HPRT1 0 0 538 538 1 1
GLA ZNF778 0 0 0 186 1 1
GLA MAN1A2 0 0 120 271 1 1
GLA SH3GL1 0 0 0 156 1 1
GLA GBA2 0 0 174 182 1 1
GLA B3GALNT1 0 900 0 914 1 1
GLA MGEA5 0 0 392 392 1 1
GLA NDUFA9 0 0 0 461 1 1
GLA LPXN 0 0 0 173 1 1
GLA CFL1 0 0 94 162 1 1
GLA VEGFA 0 0 157 156 1 2
GLA LTA4H 0 0 180 189 1 1
GLA RAB5C 0 0 134 170 1 1
GLA CERK 0 0 151 150 1 1
GLA PCMT1 0 0 0 491 1 1
GLA ACTG1 0 0 0 165 1 1
GLA TNPO1 0 0 0 202 1 1
GLA M6PR 0 0 640 648 1 1
GLA CTSD 0 0 263 355 1 2
GLA G6PD 244 0 82 337 1 1
GLA CWC25 0 0 47 651 1 1
GLA CSRP3 0 0 112 212 1 1
GLA MRI1 0 0 114 250 1 1
GLA GALP 0 0 234 300 1 1
GLA OSBPL8 0 0 0 274 1 1
GLA HEMK1 0 0 0 298 1 1
GLA RALA 0 0 259 305 1 1
GLA FN1 0 0 181 181 1 2
GLA GAL 0 0 203 325 1 1
GLA OSBPL9 0 0 0 155 1 1
GLA ZFPM1 0 0 57 441 1 1
GLA GALC 0 900 560 955 1 1
GLA CORT 0 0 59 159 1 1
GLA ZNF560 0 0 0 186 1 1
GLA KCNN4 0 0 218 218 1 1
GLA AGPAT4 0 0 0 155 1 1
GLA ATP2B1 0 0 0 566 1 1
GLA CYB5D2 0 0 0 261 1 1
GLA TERT 192 0 67 227 1 2
GLA ALPK3 0 0 123 283 1 1
GLA SLC24A5 0 0 157 156 1 1
GLA APOC4 0 0 0 190 1 1
GLA ATG5 0 0 51 196 1 2
GLA CTPS1 0 0 0 154 1 1
GLA MPL 0 0 0 248 1 1
GLA ELN 0 0 150 188 1 1
GLA PECR 0 0 123 155 1 1
GLA F9 0 0 284 284 1 1
GLA PRKAG2 0 0 505 505 1 1
GLA ATP4A 0 0 173 179 1 1
GLA CTSB 0 0 150 172 1 2
GLA PGM2L1 0 0 0 236 1 1
GLA IFT80 0 0 0 164 1 1
GLA EIF5A 0 0 0 163 1 2
GLA MYL3 0 0 324 341 1 1
GLA BACE1 0 0 66 164 1 2
GLA NAGS 0 0 180 179 1 1
GLA LRP2 270 0 294 462 1 1
GLA PRKCH 0 0 70 150 1 1
GLA CEP104 0 0 0 164 1 1
GLA MPI 0 0 147 380 1 1
GLA LRRK2 270 0 141 369 1 2
GLA ABCB1 0 0 139 180 1 2
GLA OTC 0 0 166 165 1 1
GLA MAN2A2 0 0 0 232 1 1
GLA ST6GAL2 0 0 107 302 1 1
GLA GALE 0 0 118 162 1 1
GLA ALPK2 0 0 0 181 1 1
GLA AMACR 0 0 0 189 1 1
GLA MCHR1 0 0 0 187 1 1
GLA OSBPL11 0 0 0 155 1 1
GLA COL15A1 0 0 117 212 1 1
GLA CNDP2 129 0 0 154 1 1
GLA FOS 0 0 170 169 1 2
GLA MAN2B1 0 0 134 325 1 1
GLA PSORS1C1 0 0 202 202 1 1
GLA SYNPO2 0 0 0 173 1 1
GLA TGFB1I1 0 0 0 173 1 1
GLA ASAH2 0 0 193 193 1 1
GLA PGD 129 0 68 202 1 1
GLA C18orf8 0 0 0 153 1 1
GLA GALNT1 0 0 127 187 1 1
GLA PTH 0 0 118 185 1 1
GLA PGM2 0 0 0 670 1 1
GLA PGA4 0 0 0 222 1 1
GLA ENSG00000250644 0 0 0 160 1 1
GLA COL4A5 0 0 55 263 1 1
GLA GUSB 0 0 285 463 1 1
GLA TTR 0 0 267 327 1 1
GLA RLN2 0 0 170 187 1 1
GLA MRPL50 0 0 181 198 1 1
GLA FLOT2 0 0 57 338 1 1
GLA DNAJA2 0 0 0 181 1 1
GLA TXNRD1 0 0 0 162 1 1
GLA PGM3 0 0 143 407 1 1
GLA UBE2L6 0 0 0 157 1 1
GLA SMPD1 0 0 464 475 1 1
GLA PEPD 0 0 0 170 1 1
GLA NEU3 0 900 0 906 1 1
GLA IDS 0 0 392 392 1 1
GLA SH3GL2 0 0 0 156 1 1
GLA MYH7 0 0 328 337 1 1
GLA TUBB6 0 0 0 179 1 1
GLA OXCT2 0 0 0 188 1 1
GLA LIX1 0 0 0 183 1 1
GLA TEX38 0 0 247 246 1 1
GLA ACE 0 0 504 504 1 1
GLA HSPA4L 0 0 88 154 1 1
GLA REN 0 0 246 325 1 1
GLA ASAH1 0 0 285 300 1 1
GLA CD1B 0 0 414 414 1 1
GLA DMRTA2 0 0 0 152 1 1
GLA DDX18 0 0 0 165 1 1
GLA ASPA 0 0 0 189 1 1
GLA GANAB 0 0 0 700 1 1
GLA SHMT2 0 0 51 215 1 1
GLA APP 0 0 98 292 1 2
GLA CLN3 0 0 210 214 1 2
GLA UGT8 0 900 0 907 1 1
GLA ADAMTS20 0 0 88 288 1 1
GLA CNOT2 172 0 0 171 1 1
GLA MYBPC3 0 0 469 469 1 1
GLA CAPN5 0 0 0 189 1 1
GLA SCPEP1 0 0 0 168 1 1
GLA NPHS1 0 0 202 202 1 1
GLA ACTN4 0 0 125 162 1 1
GLA SHMT1 0 0 52 182 1 1
GLA MPO 0 0 329 329 1 2
GLA GPHB5 0 0 151 150 1 1
GLA PPP4C 0 0 219 235 1 1
GLA IL6 0 0 167 167 1 2
GLA CTRL 0 0 74 386 1 2
GLA SORT1 417 0 268 555 1 1
GLA MAN2C1 0 0 0 360 1 1
GLA NANS 0 0 0 303 1 1
GLA GRIK2 0 0 431 431 1 1
GLA PSAP 0 0 306 329 1 1
GLA ETFA 0 0 294 294 1 1
GLA GALK1 0 0 0 256 1 1
GLA UGT3A2 0 0 0 165 1 1
GLA MYOM3 0 0 108 174 1 1
GLA LGALS9 0 0 0 159 1 1
GLA R3HCC1L 0 0 0 303 1 1
GLA PCSK7 0 0 66 274 1 1
GLA AKR1B10 0 900 0 901 1 1
GLA SDF4 0 0 54 226 1 1
GLA PDLIM1 0 0 0 173 1 1
GLA BCKDHA 0 0 0 223 1 1
GLA PRSS16 0 0 0 155 1 1
GLA BEND7 0 0 294 294 1 1
GLA NMI 0 0 0 302 1 1
GLA GRHPR 0 0 0 229 1 1
GLA NOS2 0 0 0 256 1 2
GLA BUD31 0 0 45 167 1 1
GLA ENO1 0 0 113 214 1 1
GLA MYPN 0 0 85 226 1 1
GLA TLR4 0 0 150 307 1 2
GLA GAPDH 0 0 202 220 1 2
GLA ENSG00000255730 0 0 0 223 1 1
GLA CCNJ 0 0 0 485 1 1
GLA UMOD 0 0 203 203 1 1
GLA GLCCI1 0 0 193 193 1 1
GLA NAPSA 0 0 0 160 1 1
GLA IL2RA 0 0 270 270 1 1
GLA RPL27 0 0 0 286 1 1
GLA ENSG00000261832 0 0 213 217 1 1
GLA NPC1 0 0 457 490 1 2
GLA NTS 0 0 85 251 1 1
GLA GALNS 0 0 370 383 1 1
GLA SMPDL3B 0 0 234 241 1 1
GLA SCARB2 0 0 391 404 1 1
GLA GNS 245 0 0 261 1 1
GLA ATP1B1 0 0 0 171 1 1
GLA ACOT11 0 0 0 524 1 1
GLA MAN1A1 0 0 86 243 1 1
GLA PGA5 0 0 0 222 1 1
GLA FURIN 0 0 74 286 1 1
GLA B4GALNT1 0 0 262 262 1 1
GLA A4GALT 0 800 561 928 1 1
GLA ALG11 0 0 0 153 1 1
GLA FUCA2 0 0 394 683 1 1
GLA LMBR1L 270 0 0 270 1 1
GLA SYNPO 0 0 155 154 1 1
GLA FXN 0 0 215 231 1 1
GLA TTN 0 0 150 235 1 1
GLA CTSE 0 0 0 160 1 1
GLA UGT3A1 0 0 0 165 1 1
GLA NANP 0 0 0 210 1 1
GLA CTSA 0 0 95 210 1 1
GLA DNAJA1 0 0 0 181 1 1
GLA SUMF1 0 0 223 524 1 1
GLA GH2 0 0 181 187 1 1
GLA FAHD2A 0 0 90 165 1 1
GLA LAMP1 114 0 190 267 1 2
GLA OSBPL5 0 0 0 273 1 1
GLA ATP2C1 0 0 0 636 1 1
GLA TP53 0 0 415 415 1 2
GLA PRKCE 0 0 0 398 1 1
GLA SCN10A 0 0 167 167 1 1
GLA TAC4 0 0 77 175 1 1
GLA CFTR 0 0 157 387 1 2
GLA GAA 0 900 413 977 1 2
GLA GMDS 0 0 0 154 1 1
GLA ARSB 0 0 425 424 1 2
GLA B4GALT6 0 800 67 822 1 1
GLA ATP6V0D1 0 0 0 165 1 1
GLA VDAC2 0 0 50 188 1 1
GLA CPVL 0 0 0 173 1 1
GLA C2orf40 0 0 138 483 1 1
GLA MCOLN1 0 0 147 205 1 2
GLA MYH6 0 0 324 326 1 1
GLA CHGB 0 0 74 326 1 1
GLA SLC22A15 0 0 219 219 1 1
GLA VGF 0 0 0 202 1 1
GLA ANKRD42 0 0 306 306 1 1
GLA ATP2B4 0 0 0 302 1 1
GLA PDLIM4 0 0 0 173 1 1
GLA PCMTD1 0 0 0 343 1 1
GLA HNF1B 0 0 0 234 1 1
GLA NEU2 0 900 0 922 1 1
GLA IL4 0 0 143 193 1 1
GLA PGK1 0 0 357 357 1 2
GLA UCHL3 0 0 0 190 1 1
GLA CNOT11 177 0 0 177 1 1
GLA ADAMTS6 0 0 87 150 1 1
GLA CUL1 0 0 135 180 1 1
GLA GALNTL6 0 0 0 160 1 1
GLA CAPN6 0 0 0 189 1 1
GLA ALB 0 0 395 394 1 2
GLA SORCS3 0 0 95 190 1 1
GLA ATP2A1 0 0 0 642 1 1
GLA PCMTD2 0 0 0 343 1 1
GLA BDH2 0 0 0 244 1 1
GLA RPS12 0 0 0 198 1 1
GLA PNO1 0 0 113 169 1 1
GLA LGALS4 0 0 96 220 1 1
GLA MAF 0 0 142 175 1 1
GLA GLB1 0 900 518 970 1 1
GLA CLCA4 0 0 0 215 1 1
GLA IDH1 0 0 0 175 1 1
GLA SCG2 0 0 139 426 1 1
GLA OLAH 0 0 177 177 1 1
GLA ACTC1 0 0 234 247 1 1
GLA R3HCC1 0 0 0 215 1 1
GLA LOC93432 0 900 417 944 1 1
GLA ATP6V0D2 0 0 0 165 1 1
GLA ACTN2 0 0 143 269 1 1
GLA LDB3 0 0 134 448 1 1
GLA ACAP2 0 0 0 186 1 1
GLA GNPTAB 0 0 135 167 1 1
GLA COL4A1 0 0 134 156 1 1
GLA GSDMB 0 0 261 261 1 1
GLA ACAP3 0 0 0 186 1 1
GLA PXN 0 0 0 173 1 1
GLA GNPAT 0 0 122 154 1 1
GLA ATP2C2 0 0 0 420 1 1
GLA PDCD4 0 0 0 150 1 2
GLA HSPB3 0 0 66 219 1 1
GLA HSPA4 0 0 155 154 1 1
GLA HNF1A 0 0 60 158 1 1
GLA AKR1B1 0 900 0 901 1 1
GLA COQ2 0 0 95 243 1 1
GLA BMP2 0 0 172 172 1 1
GLA HGSNAT 0 0 109 351 1 1
GLA SLC25A17 0 0 0 189 1 1
GLA CDC6 0 0 0 173 1 1
GLA PYHIN1 0 0 155 154 1 1
GLA TREH 0 0 162 495 1 1
GLA EFCAB14 0 0 220 220 1 1
GLA MAN2B2 0 0 0 245 1 1
GLA RPL36A 0 0 134 171 1 1
GLA ORMDL3 0 0 261 261 1 2
GLA MANBA 0 0 242 486 1 1
GLA NPC2 0 0 324 450 1 1
GLA SNCA 0 0 249 248 1 2
GLA GM2A 0 0 337 430 1 1
GLA MAN2A1 0 0 0 232 1 1
GLA TAZ 0 0 150 367 1 1
GLA NPPB 0 0 261 261 1 1
GLA KIAA0226L 0 0 0 487 1 1
GLA ENSG00000173366 0 0 134 223 1 1
GLA SI 0 900 561 961 1 1
GLA SERPINA1 0 0 180 229 1 2
GLA TPP1 0 0 112 167 1 1
GLA OTUD4 131 0 0 150 1 1
GLA ATP2B3 0 0 0 561 1 1
GLA CTSF 0 0 74 169 1 1
GLA PENK 0 0 60 204 1 1
GLA SPATS2L 0 0 298 298 1 1
GLA ACAP1 0 0 0 186 1 1
GLA LAMP2 0 0 469 480 1 2
GLA PLA2G15 0 0 138 199 1 1
GLA PCSK4 0 0 74 216 1 1
GLA ARSA 0 900 464 945 1 2
GLA WFDC2 0 0 0 188 1 1
GLA LTC4S 0 0 216 216 1 1
GLA GLB1L3 0 0 0 428 1 1
GLA C1orf109 0 0 0 817 1 1
GLA UCHL1 0 0 145 277 1 2
GLA CD8A 0 0 145 179 1 1
GLA GALK2 0 0 0 256 1 1
GLA TNNI3 0 0 340 344 1 1
GLA TPM1 0 0 249 295 1 1
GLA CD1C 0 0 397 396 1 1
GLA GANC 0 900 391 981 1 1
GLA GSR 0 0 46 192 1 1
GLA ZPBP2 0 0 190 190 1 1
GLA SFTPB 0 0 0 320 1 1
GLA ENSG00000269590 0 0 0 253 1 1
GLA ENOSF1 0 0 0 224 1 1
GLA UMPS 0 0 0 302 1 1
GLA GLB1L2 0 0 0 430 1 1
GLA QRFP 0 0 72 174 1 1
GLA ADH7 0 0 0 202 1 1
GLA WDR48 0 0 0 187 1 1
GLA UGCG 0 0 602 610 1 1
GLA COX4I1 0 0 0 286 1 1
GLA SGPL1 0 0 93 188 1 1
GLA DNAJA4 0 0 0 181 1 1
GLA ACTN3 0 0 0 183 1 1
GLA TFEB 0 0 248 248 1 2
GLA B2M 0 0 293 308 1 1
GLA GAL3ST1 0 900 233 921 1 1
GLA EPRS 0 0 0 179 1 1
GLA NEU1 0 900 212 941 1 1
GLA ACTB 0 0 128 172 1 2
GLA INS 0 0 246 245 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004557 Molecular Function alpha-galactosidase activity enables IBA
GO:0004557 Molecular Function alpha-galactosidase activity enables IDA
GO:0004557 Molecular Function alpha-galactosidase activity enables IMP
GO:0003824 Molecular Function catalytic activity enables IDA
GO:0016936 Molecular Function galactoside binding enables IEA
GO:0016787 Molecular Function hydrolase activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0005102 Molecular Function signaling receptor binding enables IDA
GO:0016139 Biological Process glycoside catabolic process involved_in IBA
GO:0046479 Biological Process glycosphingolipid catabolic process involved_in IDA
GO:0046479 Biological Process glycosphingolipid catabolic process involved_in IMP
GO:0046479 Biological Process glycosphingolipid catabolic process involved_in TAS
GO:0046477 Biological Process glycosylceramide catabolic process involved_in ISS
GO:0045019 Biological Process negative regulation of nitric oxide biosynthetic process involved_in ISS
GO:0051001 Biological Process negative regulation of nitric-oxide synthase activity involved_in ISS
GO:0009311 Biological Process oligosaccharide metabolic process involved_in IBA
GO:0009311 Biological Process oligosaccharide metabolic process involved_in IDA
GO:0005794 Cellular Component Golgi apparatus located_in IMP
GO:0035578 Cellular Component azurophil granule lumen located_in TAS
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005737 Cellular Component cytoplasm located_in IMP
GO:0070062 Cellular Component extracellular exosome located_in HDA
GO:0005576 Cellular Component extracellular region located_in IDA
GO:0005576 Cellular Component extracellular region located_in IMP
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0043202 Cellular Component lysosomal lumen located_in TAS
GO:0005764 Cellular Component lysosome located_in IMP
GO:0005764 Cellular Component lysosome located_in TAS
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
Glycosphingolipid metabolism Reactome R-HSA-1660662
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Sphingolipid metabolism Reactome R-HSA-428157
Metabolism of lipids Reactome R-HSA-556833
Neutrophil degranulation Reactome R-HSA-6798695
Degradation pathway of sphingolipids, including diseases (WP4153) WikiPathways WP4153_r123688
Ciliary landscape (WP4352) WikiPathways WP4352_r102218
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_176252 1 miscRNA transcript variant 6 NC_000023 Reference
NR_164783 1 miscRNA transcript variant 2 NC_000023 Reference
NR_176253 1 miscRNA transcript variant 7 NC_000023 Reference
NM_000169 3 mRNA transcript variant 1 NC_000023 Reference
NM_001406747 1 mRNA transcript variant 3 NC_000023 Reference
XM_047441990 1 mRNA transcript variant X1 NC_000023 Reference
NM_001406748 1 mRNA transcript variant 4 NC_000023 Reference
NM_001406749 1 mRNA transcript variant 5 NC_000023 Reference