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H19

H19 imprinted maternally expressed transcript
General Information
Name H19 imprinted maternally expressed transcript
Alias
  • H19, imprinted maternally expressed transcript (non-protein coding)
  • H19, imprinted maternally expressed untranslated mRNA
  • MIR675 host
  • adult skeletal muscle
  • long intergenic non-protein coding RNA 8
Gene_family Long non-coding RNAs with non-systematic symbols|MicroRNA non-coding host genes
organism Homo sapiens
entrez_id 283120
location 11p15.5
transcript_count 7
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
H19 BioGRID YAP1 GeneID BioGRID Affinity Capture-RNA
H19 BioGRID APEX1 GeneID BioGRID Affinity Capture-RNA
H19 BioGRID AGO2 GeneID BioGRID Affinity Capture-RNA
StringDB
A B experiments database textmining combined score hadb nhadb
Ontologies
ID Category Term Effect Evidence PubMed
GO:0098586 Biological Process cellular response to virus involved_in IMP
GO:0035196 Biological Process miRNA processing involved_in IMP
GO:2001170 Biological Process negative regulation of ATP biosynthetic process acts_upstream_of IMP
GO:2000378 Biological Process negative regulation of reactive oxygen species metabolic process acts_upstream_of IMP
GO:1900017 Biological Process positive regulation of cytokine production involved in inflammatory response acts_upstream_of IMP
GO:1903945 Biological Process positive regulation of hepatocyte apoptotic process acts_upstream_of IMP
GO:0051897 Biological Process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_of IMP
GO:1903428 Biological Process positive regulation of reactive oxygen species biosynthetic process acts_upstream_of IMP
Pathways
Name DB ID
Aspirin and miRNAs (WP4707) WikiPathways WP4707_r116586
lncRNA in canonical Wnt signaling and colorectal cancer (WP4258) WikiPathways WP4258_r123417
H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (WP3969) WikiPathways WP3969_r123402
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_131224 1 ncRNA transcript variant 3 NC_000011 Reference
NR_185828 1 ncRNA transcript variant 4 NC_000011 Reference
NR_185829 1 ncRNA transcript variant 5 NC_000011 Reference
NR_185830 1 ncRNA transcript variant 6 NC_000011 Reference
NR_185831 1 ncRNA transcript variant 7 NC_000011 Reference
NR_131223 2 ncRNA transcript variant 2 NC_000011 Reference
NR_002196 3 ncRNA transcript variant 1 NC_000011 Reference