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GPER1

G protein-coupled estrogen receptor 1
General Information
Name G protein-coupled estrogen receptor 1
Alias
  • G-protein coupled estrogen receptor 1
  • G protein-coupled receptor 30
  • IL8-related receptor DRY12
  • chemoattractant receptor-like 2
  • chemokine receptor-like 2
  • constitutively expressed peptide-like receptor
  • flow-induced endothelial G-protein coupled receptor 1
  • heptahelix receptor
  • lymphocyte-derived G-protein coupled receptor
  • membrane estrogen receptor
Gene_family G protein-coupled estrogen receptor
organism Homo sapiens
entrez_id 2852
location 7p22.3
transcript_count 3
exon_count 3
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
    Stringdb G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17- beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...]
    nextProt G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
GPER1 BioGRID ESR1 GeneID BioGRID Affinity Capture-Western
GPER1 BioGRID TP53 GeneID BioGRID Negative Genetic
GPER1 BioGRID PTTG1 GeneID BioGRID Synthetic Growth Defect
GPER1 BioGRID PTEN GeneID BioGRID Synthetic Growth Defect
GPER1 Protein None None BIND E2 interacts with GPR30.
StringDB
A B experiments database textmining combined score hadb nhadb
GPER1 FOS 0 0 562 568 1 2
GPER1 POC5 0 0 61 175 1 1
GPER1 TPH2 0 0 142 237 1 1
GPER1 ZNF157 0 0 114 208 1 1
GPER1 GRIN2A 0 0 154 212 1 1
GPER1 RHOD 0 0 0 197 1 1
GPER1 RIPPLY3 0 0 82 244 1 1
GPER1 STAT5A 0 0 134 225 1 1
GPER1 COMP 0 0 55 227 1 1
GPER1 SUCLG2 0 0 167 167 1 1
GPER1 RAMP1 0 0 123 366 1 1
GPER1 PDYN 0 0 235 235 1 1
GPER1 VIPR1 0 0 134 271 1 1
GPER1 FAM101A 0 0 82 262 1 1
GPER1 TIAF1 0 0 75 327 1 1
GPER1 BMP6 0 0 148 171 1 1
GPER1 KRAS 0 0 96 177 1 2
GPER1 ADRBK1 0 0 157 158 1 1
GPER1 CACNA1I 0 0 235 235 1 1
GPER1 MMP2 0 0 248 248 1 2
GPER1 PTH 0 0 152 151 1 1
GPER1 GPBAR1 0 0 194 220 1 1
GPER1 NCOA3 0 0 259 258 1 1
GPER1 CYP11A1 0 0 294 310 1 1
GPER1 NOS1 0 0 193 193 1 1
GPER1 NCOA2 0 0 143 166 1 1
GPER1 CCNA2 0 0 223 223 1 1
GPER1 LRP2 0 0 160 205 1 1
GPER1 CAV1 0 0 528 537 1 2
GPER1 MAPK11 0 0 101 164 1 1
GPER1 FGF23 0 0 0 188 1 1
GPER1 DHRS11 0 0 317 317 1 1
GPER1 NHSL1 0 0 103 240 1 1
GPER1 AMH 0 0 166 184 1 1
GPER1 PTGER3 0 0 150 193 1 1
GPER1 HPCAL1 0 0 74 203 1 1
GPER1 GNAO1 0 0 108 201 1 1
GPER1 GRIN2B 0 0 244 259 1 1
GPER1 GABBR1 0 0 138 197 1 1
GPER1 GPR173 0 0 108 171 1 1
GPER1 SRD5A1 0 0 193 230 1 1
GPER1 CYP19A1 0 0 686 707 1 2
GPER1 CAV3 0 0 465 465 1 1
GPER1 JUN 0 0 394 394 1 2
GPER1 GPR61 0 0 908 908 1 1
GPER1 ACSF2 0 0 93 329 1 1
GPER1 ESRRG 0 0 673 681 1 1
GPER1 BACE2 0 0 46 192 1 1
GPER1 PSMG1 0 0 0 261 1 1
GPER1 PITPNM3 0 0 194 387 1 1
GPER1 HSP90AA1 0 0 185 185 1 2
GPER1 AFP 0 0 456 460 1 2
GPER1 LIMK1 0 0 146 181 1 1
GPER1 PTGS2 0 0 235 235 1 2
GPER1 CHRM1 0 0 145 198 1 1
GPER1 C7orf50 0 0 103 159 1 1
GPER1 CASP3 0 0 340 340 1 2
GPER1 ACSBG1 0 0 324 340 1 1
GPER1 ACE 0 0 241 259 1 1
GPER1 DNMT1 0 0 157 156 1 2
GPER1 GLP1R 0 0 170 523 1 1
GPER1 REN 0 0 490 490 1 1
GPER1 INS 0 0 460 459 1 2
GPER1 ASAH1 0 0 217 234 1 1
GPER1 STS 0 0 307 325 1 1
GPER1 ACTB 0 0 452 458 1 2
GPER1 PAQR8 0 0 391 390 1 1
GPER1 SIM2 0 0 49 292 1 1
GPER1 MMP9 0 0 323 323 1 2
GPER1 GRM1 0 0 476 804 1 1
GPER1 OR4D1 0 0 213 213 1 1
GPER1 MAPK3 0 0 602 602 1 2
GPER1 CALM2 0 0 0 298 1 1
GPER1 RHOA 0 0 234 234 1 2
GPER1 AR 0 0 559 581 1 2
GPER1 ADM 0 0 128 182 1 2
GPER1 GNRH1 0 0 565 577 1 1
GPER1 ARRB1 0 0 134 152 1 1
GPER1 GSK3B 0 0 122 176 1 2
GPER1 CDKN1A 0 0 134 155 1 2
GPER1 CXCL12 0 0 157 156 1 2
GPER1 CCL18 0 0 460 460 1 1
GPER1 HSD3B1 0 0 321 321 1 1
GPER1 CACNA1H 0 0 165 168 1 1
GPER1 ESR2 0 0 912 921 1 1
GPER1 TSPO 0 0 181 181 1 1
GPER1 WISP2 0 0 160 159 1 1
GPER1 GPR126 0 0 106 216 1 1
GPER1 GPI 0 0 702 702 1 2
GPER1 PHB2 0 0 101 162 1 1
GPER1 MORF4L1 0 0 68 162 1 1
GPER1 GPR84 0 0 130 219 1 1
GPER1 NR3C2 0 0 504 504 1 1
GPER1 DRD2 0 0 134 224 1 1
GPER1 GFAP 0 0 134 155 1 2
GPER1 SNAI1 0 0 202 202 1 1
GPER1 IL10 0 0 216 216 1 2
GPER1 LPHN1 0 0 0 155 1 1
GPER1 GLP2R 0 0 66 194 1 1
GPER1 TAC1 0 0 168 167 1 1
GPER1 HTR1A 0 0 479 483 1 1
GPER1 DLG4 0 0 956 957 1 2
GPER1 AGRP 0 0 194 194 1 1
GPER1 CHRM3 0 0 103 241 1 1
GPER1 LHCGR 0 0 457 457 1 1
GPER1 IGF2 0 0 180 179 1 1
GPER1 CTSD 0 0 142 159 1 2
GPER1 SLC4A4 0 0 181 181 1 1
GPER1 RERG 0 0 167 219 1 1
GPER1 SHC1 0 0 334 334 1 1
GPER1 CDH1 0 0 234 234 1 2
GPER1 PGRMC2 0 0 335 486 1 1
GPER1 CFL1 0 0 212 212 1 1
GPER1 PTH1R 0 0 188 228 1 1
GPER1 ADRA2A 0 0 108 195 1 1
GPER1 GIPR 0 0 70 234 1 1
GPER1 IL4 0 0 160 159 1 1
GPER1 C9orf84 0 0 172 171 1 1
GPER1 CCNA1 0 0 218 218 1 1
GPER1 OPRL1 0 0 324 171 1 1
GPER1 OR13F1 0 0 150 235 1 1
GPER1 LEP 0 0 325 325 1 1
GPER1 S1PR1 0 0 137 372 1 1
GPER1 ALB 0 0 427 447 1 2
GPER1 DRD3 0 0 70 230 1 1
GPER1 CCL2 0 0 181 181 1 2
GPER1 HSPG2 0 0 43 151 1 1
GPER1 VEGFA 0 0 323 323 1 2
GPER1 AACS 0 0 0 215 1 1
GPER1 PTEN 44 0 234 236 1 2
GPER1 YAP1 0 0 180 179 1 2
GPER1 CD164L2 0 0 182 181 1 1
GPER1 GRM2 0 0 289 352 1 1
GPER1 CYP1B1 0 0 303 318 1 1
GPER1 PIK3R1 0 0 175 175 1 1
GPER1 GCGR 0 0 122 277 1 1
GPER1 SLC6A3 0 0 241 240 1 1
GPER1 PGRMC1 0 0 504 638 1 1
GPER1 RGS9 0 0 0 432 1 1
GPER1 CRHR1 0 0 155 173 1 1
GPER1 SNRPD2 0 0 93 155 1 1
GPER1 SRD5A2 0 0 143 205 1 1
GPER1 CHAT 0 0 212 231 1 1
GPER1 PPARA 0 0 203 217 1 2
GPER1 GNAS 0 800 0 925 1 1
GPER1 KBTBD11 0 0 112 167 1 1
GPER1 CRH 0 0 266 279 1 1
GPER1 SLC1A2 0 0 248 248 1 1
GPER1 CASP9 0 0 155 154 1 2
GPER1 POMC 0 0 466 467 1 1
GPER1 SCTR 0 0 144 163 1 1
GPER1 CYCS 0 0 194 194 1 2
GPER1 ESR1 0 0 982 985 1 2
GPER1 MIER1 0 0 394 394 1 1
GPER1 NOX1 0 0 193 193 1 1
GPER1 IGFBP1 0 0 146 199 1 1
GPER1 BAI1 0 0 112 167 1 1
GPER1 RGS2 0 0 181 182 1 1
GPER1 SULT1E1 0 0 282 282 1 1
GPER1 PRL 0 0 370 370 1 1
GPER1 EGF 0 0 503 503 1 2
GPER1 SIRT1 0 0 181 181 1 2
GPER1 TMEM63A 0 0 103 159 1 1
GPER1 CASR 0 0 141 282 1 2
GPER1 PTGIS 0 0 181 181 1 1
GPER1 FN1 0 0 304 304 1 2
GPER1 ADIPOQ 0 0 244 243 1 2
GPER1 SHANK2 0 0 47 151 1 1
GPER1 PTK2 0 800 112 814 1 2
GPER1 COQ3 0 0 57 156 1 1
GPER1 ZNF217 0 0 96 184 1 1
GPER1 VIM 0 0 124 184 1 2
GPER1 PAQR6 0 0 145 207 1 1
GPER1 PAQR5 0 0 335 335 1 1
GPER1 CALCA 0 0 181 195 1 1
GPER1 GNPTG 0 0 0 469 1 1
GPER1 HSD17B3 0 0 142 160 1 1
GPER1 CYP11B2 0 0 262 279 1 1
GPER1 VR1 0 0 165 166 1 1
GPER1 CALCRL 0 0 182 199 1 1
GPER1 TFF1 0 0 281 281 1 1
GPER1 GRM3 0 0 171 237 1 1
GPER1 TIMP2 0 0 135 221 1 1
GPER1 RGS11 0 0 0 248 1 1
GPER1 SPHK1 0 0 151 150 1 2
GPER1 RAMP2 0 0 126 352 1 1
GPER1 SRD5A3 0 0 135 158 1 1
GPER1 CTGF 0 0 401 400 1 1
GPER1 CDH7 0 0 57 152 1 1
GPER1 CSK 0 0 137 155 1 1
GPER1 CMA1 0 0 181 181 1 1
GPER1 NR3C1 0 0 355 355 1 1
GPER1 ADRB1 0 0 167 167 1 1
GPER1 PAQR9 0 0 193 314 1 1
GPER1 ARNTL 0 0 61 164 1 1
GPER1 STRN 0 0 432 432 1 1
GPER1 MAPK1 0 0 161 161 1 2
GPER1 IGF1 0 0 458 457 1 2
GPER1 PTER 0 0 48 308 1 1
GPER1 AREG 0 0 174 257 1 1
GPER1 NPY 0 0 337 352 1 1
GPER1 PITX1 0 0 67 160 1 1
GPER1 BRCA1 0 0 163 163 1 2
GPER1 MAP2K1 0 0 212 212 1 1
GPER1 CNR1 0 0 217 233 1 1
GPER1 ESRRB 0 0 323 341 1 1
GPER1 PRLR 0 0 150 183 1 1
GPER1 KCNJ3 0 0 141 164 1 1
GPER1 FGF2 0 0 151 150 1 2
GPER1 GCG 0 0 282 282 1 1
GPER1 IL17RC 0 0 0 157 1 1
GPER1 PAQR7 0 0 459 459 1 1
GPER1 HSD17B10 0 0 83 241 1 1
GPER1 SHANK1 0 0 69 170 1 1
GPER1 RHOF 0 0 0 286 1 1
GPER1 CCND2 0 0 223 223 1 1
GPER1 AGT 0 0 108 261 1 1
GPER1 SLC7A1 0 0 370 393 1 1
GPER1 P4HB 0 0 246 261 1 2
GPER1 INSL3 0 0 181 181 1 1
GPER1 GNAQ 0 0 935 935 1 1
GPER1 GRM4 0 0 90 185 1 1
GPER1 RBFOX3 0 0 193 193 1 1
GPER1 TAC3 0 0 211 211 1 1
GPER1 ZDHHC21 0 0 142 175 1 1
GPER1 KISS1R 0 0 370 203 1 1
GPER1 MMP3 0 0 99 189 1 1
GPER1 SLC1A3 0 0 181 181 1 1
GPER1 MYC 0 0 240 239 1 2
GPER1 HTR2C 0 0 150 202 1 1
GPER1 VDR 0 0 194 209 1 2
GPER1 BDNF 0 0 321 321 1 2
GPER1 WNT5A 0 0 94 150 1 2
GPER1 SLC6A4 0 0 143 206 1 1
GPER1 SCP2 0 0 74 170 1 1
GPER1 IGF1R 0 0 413 412 1 2
GPER1 GPR63 0 0 71 170 1 1
GPER1 TPH1 0 0 167 224 1 1
GPER1 TNF 0 0 293 293 1 2
GPER1 OXTR 0 0 294 196 1 1
GPER1 SLC18A2 0 0 193 193 1 1
GPER1 NUCKS1 0 0 57 201 1 1
GPER1 IDE 0 0 0 190 1 1
GPER1 NDC80 0 0 173 173 1 1
GPER1 CAT 0 0 181 181 1 2
GPER1 ENSG00000264813 0 0 234 245 1 1
GPER1 SLC9A3R1 0 0 509 509 1 1
GPER1 GRIA1 0 0 211 211 1 1
GPER1 SLC25A18 0 0 167 167 1 1
GPER1 NCOA1 0 0 232 231 1 1
GPER1 HBEGF 0 0 417 416 1 1
GPER1 STAT3 0 0 267 267 1 2
GPER1 GPR85 0 0 48 195 1 1
GPER1 OPRM1 0 0 372 158 1 1
GPER1 ZDHHC7 0 0 175 189 1 1
GPER1 SH3BGR 0 0 66 303 1 1
GPER1 EVL 0 0 53 153 1 1
GPER1 HSD17B1 0 0 310 309 1 1
GPER1 PLEKHG3 0 0 92 154 1 1
GPER1 CALM3 0 0 112 349 1 1
GPER1 ATP2B4 0 0 475 475 1 1
GPER1 SNRPD1 0 0 112 167 1 2
GPER1 TMEM74B 0 0 165 177 1 1
GPER1 HGS 0 0 0 188 1 2
GPER1 STAR 0 0 273 286 1 1
GPER1 ACTA2 0 0 70 163 1 1
GPER1 NOS3 0 0 519 519 1 2
GPER1 NR5A1 0 0 318 317 1 1
GPER1 LPHN2 0 0 0 212 1 1
GPER1 FSHR 0 0 261 311 1 1
GPER1 CCND1 0 0 423 422 1 2
GPER1 LOXL1 0 0 69 166 1 1
GPER1 HOXB7 0 0 0 157 1 1
GPER1 GPR143 0 0 82 187 1 1
GPER1 GKAP1 0 0 95 165 1 1
GPER1 GREB1 0 0 287 397 1 1
GPER1 HDAC2 0 0 138 161 1 1
GPER1 BCL2L2 0 0 113 271 1 1
GPER1 ABCG2 0 0 169 169 1 1
GPER1 TNFRSF11B 0 0 96 206 1 1
GPER1 AKAP5 0 0 703 749 1 1
GPER1 LOX 0 0 167 167 1 2
GPER1 HOXA13 0 0 46 162 1 1
GPER1 SAG 0 0 264 264 1 1
GPER1 TP53 130 0 289 354 1 2
GPER1 SGK1 0 0 134 156 1 2
GPER1 PRKCE 0 0 73 173 1 1
GPER1 NTRK1 0 0 155 154 1 1
GPER1 PPP1R1C 0 0 81 172 1 1
GPER1 AHR 0 0 325 326 1 2
GPER1 PGR 0 0 601 667 1 1
GPER1 FFAR1 0 0 210 249 1 1
GPER1 CDK1 0 0 444 444 1 2
GPER1 GPR39 0 0 122 194 1 1
GPER1 EGFR 0 0 836 839 1 2
GPER1 PRKG1 0 0 165 165 1 1
GPER1 S100A6 0 0 157 156 1 1
GPER1 GAD1 0 0 142 165 1 1
GPER1 GRM7 0 0 47 260 1 1
GPER1 COMT 0 0 235 235 1 1
GPER1 IL6 0 0 369 369 1 2
GPER1 APOD 0 0 72 210 1 1
GPER1 EIF2AK3 0 0 290 290 1 2
GPER1 SIM1 0 0 52 150 1 1
GPER1 GRM8 0 0 113 477 1 1
GPER1 THRA 0 0 138 170 1 1
GPER1 LPAR1 0 0 183 265 1 1
GPER1 OCLN 0 0 150 168 1 1
GPER1 CYR61 0 0 142 215 1 1
GPER1 NOTCH1 0 0 202 202 1 2
GPER1 SRC 0 800 593 915 1 2
GPER1 C17orf67 0 0 127 285 1 1
GPER1 SLC2A4 0 0 155 154 1 1
GPER1 RPL13A 0 0 95 189 1 1
GPER1 TRIM59 0 0 56 201 1 1
GPER1 OXT 0 0 417 417 1 1
GPER1 GPR1 0 0 339 202 1 1
GPER1 FOXO3 0 0 139 157 1 2
GPER1 MTOR 0 0 264 264 1 2
GPER1 APOE 0 0 181 181 1 2
GPER1 PSMC6 0 0 180 179 1 1
GPER1 CALM1 0 0 143 504 1 1
GPER1 BCAR3 0 0 90 152 1 1
GPER1 PRKCD 0 0 263 263 1 2
GPER1 CTNNB1 0 0 247 246 1 2
GPER1 HRAS 0 0 134 198 1 2
GPER1 GPR12 0 0 208 237 1 1
GPER1 GRM6 0 0 46 193 1 1
GPER1 TRPV1 0 0 165 166 1 2
GPER1 GPR62 0 0 909 909 1 1
GPER1 RB1 0 0 174 173 1 2
GPER1 HSD17B2 0 0 181 181 1 1
GPER1 EGR1 0 0 294 294 1 2
GPER1 TGFB1 0 0 72 164 1 2
GPER1 STAT5B 0 0 125 179 1 1
GPER1 CSN3 0 0 170 169 1 1
GPER1 GPR101 0 0 162 174 1 1
GPER1 EDN1 0 0 324 323 1 1
GPER1 HIF1A 0 0 294 294 1 2
GPER1 IL1B 0 0 321 321 1 2
GPER1 SP1 0 0 213 213 1 2
GPER1 CXCL8 0 0 230 229 1 2
GPER1 EGFL6 0 0 54 199 1 1
GPER1 FOXP3 0 0 181 181 1 2
GPER1 RPL30 0 0 154 159 1 1
GPER1 RUNX2 0 0 180 179 1 2
GPER1 TLR4 0 0 159 158 1 2
GPER1 LPHN3 0 0 0 155 1 1
GPER1 DLG1 0 0 693 693 1 1
GPER1 GAPDH 0 0 391 390 1 2
GPER1 NOX4 0 0 166 165 1 2
GPER1 CYP1A1 0 0 171 171 1 2
GPER1 KCNJ6 0 0 74 234 1 1
GPER1 SLC39A9 0 0 324 353 1 1
GPER1 PRR15L 0 0 107 170 1 1
GPER1 SLC18A3 0 0 124 168 1 1
GPER1 GPR3 0 0 166 223 1 1
GPER1 RXFP1 0 0 95 186 1 1
GPER1 ACE2 0 0 205 205 1 2
GPER1 NTRK2 0 0 181 181 1 1
GPER1 MAP2K7 0 0 321 321 1 1
GPER1 GNAL 0 0 0 402 1 1
GPER1 HOXA10 0 0 120 276 1 1
GPER1 CD4 0 0 162 161 1 2
GPER1 COL11A2 0 0 0 176 1 1
GPER1 CACNA1G 0 0 264 264 1 1
GPER1 CYP21A2 0 0 134 169 1 1
GPER1 SLC9A1 0 0 161 167 1 1
GPER1 KISS1 0 0 468 468 1 1
GPER1 FOXA1 0 0 195 195 1 1
GPER1 PELP1 0 0 469 472 1 2
GPER1 RAMP3 0 0 725 744 1 1
GPER1 PPARG 0 0 443 443 1 2
GPER1 AKT1 0 0 604 611 1 2
GPER1 BCL2L1 0 0 183 183 1 2
GPER1 PPP1R9B 0 0 181 210 1 1
GPER1 APLN 0 0 137 154 1 1
GPER1 TH 0 0 183 183 1 2
GPER1 ANXA5 0 0 170 169 1 2
GPER1 CCNB1 0 0 209 209 1 1
GPER1 SHBG 0 0 366 410 1 1
GPER1 HSD11B2 0 0 194 194 1 1
GPER1 PNOC 0 0 301 301 1 1
GPER1 RAPGEF4 0 0 194 244 1 1
GPER1 NGF 0 0 310 343 1 2
GPER1 DDR1 0 0 450 450 1 1
GPER1 ERBB2 0 0 452 452 1 2
GPER1 RGS4 0 0 113 168 1 1
GPER1 RGS20 0 0 210 296 1 1
GPER1 GPRC6A 0 0 194 199 1 1
GPER1 NR1I2 0 0 229 229 1 1
GPER1 ESRRA 0 0 468 492 1 1
GPER1 CYP17A1 0 0 281 313 1 1
GPER1 NOTCH4 0 0 194 194 1 1
GPER1 GPR18 0 0 203 154 1 1
GPER1 GPRC5A 0 0 170 192 1 1
GPER1 CCK 0 0 181 181 1 1
GPER1 HSD11B1 0 0 141 164 1 1
GPER1 GJA1 0 0 162 161 1 1
GPER1 IFNG 0 0 123 155 1 2
GPER1 GRM5 0 0 261 478 1 1
GPER1 RAPGEF3 0 0 202 239 1 1
GPER1 CREB1 0 0 556 572 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0038054 Molecular Function G protein-coupled estrogen receptor activity enables ISS
GO:0004930 Molecular Function G protein-coupled receptor activity enables TAS
GO:0003682 Molecular Function chromatin binding enables IDA
GO:0030284 Molecular Function nuclear estrogen receptor activity enables IBA
GO:0030284 Molecular Function nuclear estrogen receptor activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0005496 Molecular Function steroid binding enables IDA
GO:1990239 Molecular Function steroid hormone binding enables IDA
GO:0007186 Biological Process G protein-coupled receptor signaling pathway involved_in IMP
GO:0007189 Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway involved_in IDA
GO:0030263 Biological Process apoptotic chromosome condensation involved_in ISS
GO:0007049 Biological Process cell cycle involved_in IEA
GO:0030154 Biological Process cell differentiation involved_in IEA
GO:0071392 Biological Process cellular response to estradiol stimulus involved_in IBA
GO:0071392 Biological Process cellular response to estradiol stimulus involved_in IDA
GO:0071333 Biological Process cellular response to glucose stimulus involved_in ISS
GO:0071389 Biological Process cellular response to mineralocorticoid stimulus involved_in ISS
GO:0071375 Biological Process cellular response to peptide hormone stimulus involved_in IDA
GO:0071356 Biological Process cellular response to tumor necrosis factor involved_in IDA
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0030518 Biological Process intracellular steroid hormone receptor signaling pathway involved_in IBA
GO:0030518 Biological Process intracellular steroid hormone receptor signaling pathway involved_in IDA
GO:0070373 Biological Process negative regulation of ERK1 and ERK2 cascade involved_in IMP
GO:0010948 Biological Process negative regulation of cell cycle process involved_in IMP
GO:0008285 Biological Process negative regulation of cell population proliferation involved_in ISS
GO:0045599 Biological Process negative regulation of fat cell differentiation involved_in ISS
GO:0010629 Biological Process negative regulation of gene expression involved_in IMP
GO:0010629 Biological Process negative regulation of gene expression involved_in ISS
GO:0050728 Biological Process negative regulation of inflammatory response involved_in IDA
GO:0002695 Biological Process negative regulation of leukocyte activation involved_in IDA
GO:0051055 Biological Process negative regulation of lipid biosynthetic process involved_in ISS
GO:0051898 Biological Process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IMP
GO:1904706 Biological Process negative regulation of vascular associated smooth muscle cell proliferation involved_in IMP
GO:0007399 Biological Process nervous system development involved_in IEA
GO:0019228 Biological Process neuronal action potential involved_in ISS
GO:0030264 Biological Process nuclear fragmentation involved in apoptotic nuclear change involved_in ISS
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IDA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in ISS
GO:0045745 Biological Process positive regulation of G protein-coupled receptor signaling pathway involved_in IDA
GO:0043410 Biological Process positive regulation of MAPK cascade involved_in ISS
GO:0043065 Biological Process positive regulation of apoptotic process involved_in ISS
GO:2000724 Biological Process positive regulation of cardiac vascular smooth muscle cell differentiation involved_in IMP
GO:0030335 Biological Process positive regulation of cell migration involved_in IMP
GO:0008284 Biological Process positive regulation of cell population proliferation involved_in IMP
GO:0043280 Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process involved_in ISS
GO:0007204 Biological Process positive regulation of cytosolic calcium ion concentration involved_in ISS
GO:2000353 Biological Process positive regulation of endothelial cell apoptotic process involved_in ISS
GO:0045742 Biological Process positive regulation of epidermal growth factor receptor signaling pathway involved_in IDA
GO:2001238 Biological Process positive regulation of extrinsic apoptotic signaling pathway involved_in ISS
GO:0010628 Biological Process positive regulation of gene expression involved_in IMP
GO:0010628 Biological Process positive regulation of gene expression involved_in ISS
GO:0032962 Biological Process positive regulation of inositol trisphosphate biosynthetic process involved_in IDA
GO:0032024 Biological Process positive regulation of insulin secretion involved_in ISS
GO:0050769 Biological Process positive regulation of neurogenesis involved_in ISS
GO:0001956 Biological Process positive regulation of neurotransmitter secretion involved_in ISS
GO:0051897 Biological Process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IDA
GO:1903078 Biological Process positive regulation of protein localization to plasma membrane involved_in IDA
GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in IDA
GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in ISS
GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in ISS
GO:0051281 Biological Process positive regulation of release of sequestered calcium ion into cytosol involved_in IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in ISS
GO:0070474 Biological Process positive regulation of uterine smooth muscle contraction involved_in IDA
GO:0051726 Biological Process regulation of cell cycle involved_in ISS
GO:0051480 Biological Process regulation of cytosolic calcium ion concentration involved_in ISS
GO:0043401 Biological Process steroid hormone mediated signaling pathway involved_in IDA
GO:0042311 Biological Process vasodilation acts_upstream_of_positive_effect ISS
GO:0005794 Cellular Component Golgi apparatus is_active_in IBA
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0000139 Cellular Component Golgi membrane located_in IEA
GO:0030424 Cellular Component axon located_in ISS
GO:0043679 Cellular Component axon terminus located_in ISS
GO:0005737 Cellular Component cytoplasm located_in ISS
GO:0030659 Cellular Component cytoplasmic vesicle membrane located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0030425 Cellular Component dendrite located_in ISS
GO:0043198 Cellular Component dendritic shaft located_in ISS
GO:0044327 Cellular Component dendritic spine head located_in ISS
GO:0032591 Cellular Component dendritic spine membrane located_in ISS
GO:0005769 Cellular Component early endosome located_in IDA
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IEA
GO:0098686 Cellular Component hippocampal mossy fiber to CA3 synapse located_in IEA
GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
GO:0045095 Cellular Component keratin filament located_in IDA
GO:0031966 Cellular Component mitochondrial membrane located_in ISS
GO:0005635 Cellular Component nuclear envelope located_in IDA
GO:0005730 Cellular Component nucleolus located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005634 Cellular Component nucleus located_in IDA
GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IDA
GO:0005886 Cellular Component plasma membrane NOT located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0014069 Cellular Component postsynaptic density located_in ISS
GO:0048786 Cellular Component presynaptic active zone located_in ISS
GO:0042734 Cellular Component presynaptic membrane located_in ISS
GO:0055037 Cellular Component recycling endosome located_in IDA
GO:0005802 Cellular Component trans-Golgi network located_in IDA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Signaling by GPCR Reactome R-HSA-372790
Class A/1 (Rhodopsin-like receptors) Reactome R-HSA-373076
Peptide ligand-binding receptors Reactome R-HSA-375276
GPCR downstream signalling Reactome R-HSA-388396
G alpha (s) signalling events Reactome R-HSA-418555
G alpha (i) signalling events Reactome R-HSA-418594
GPCR ligand binding Reactome R-HSA-500792
GPER1 signaling Reactome R-HSA-9634597
Estrogen signaling pathway (WP712) WikiPathways WP712_r109450
GPCRs, class A rhodopsin-like (WP455) WikiPathways WP455_r117740
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001039966 2 mRNA transcript variant 3 NC_000007 Reference
NM_001505 3 mRNA transcript variant 2 NC_000007 Reference
NM_001098201 3 mRNA transcript variant 4 NC_000007 Reference