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GPX4

glutathione peroxidase 4
General Information
Name glutathione peroxidase 4
Alias
  • phospholipid hydroperoxide glutathione peroxidase
  • epididymis secretory sperm binding protein
  • phospholipid hydroperoxidase
  • phospholipid hydroperoxide glutathione peroxidase, mitochondrial
  • selenoprotein GPX4
  • sperm nucleus glutathione peroxidase
Gene_family Selenoproteins
organism Homo sapiens
entrez_id 2879
location 19p13.3
transcript_count 4
exon_count 8
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]
    Stringdb Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...]
    nextProt Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
GPX4 BioGRID TRIM59 GeneID BioGRID Affinity Capture-Western
GPX4 BioGRID OTUB1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
GPX4 BioGRID CST1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
GPX4 BioGRID SHARPIN GeneID BioGRID Affinity Capture-Western
GPX4 BioGRID RNF31 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
GPX4 BioGRID H3C3 GeneID BioGRID Proximity Label-MS
GPX4 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID PRKN GeneID BioGRID Proximity Label-MS
GPX4 BioGRID PTPN11 GeneID BioGRID Co-fractionation
GPX4 BioGRID PLOD2 GeneID BioGRID Co-fractionation
GPX4 BioGRID PLOD1 GeneID BioGRID Co-fractionation
GPX4 BioGRID ATP5F1A GeneID BioGRID Co-fractionation
GPX4 BioGRID RAB35 GeneID BioGRID Co-fractionation
GPX4 BioGRID HNRNPA0 GeneID BioGRID Co-fractionation
GPX4 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID RIT1 GeneID BioGRID Negative Genetic
GPX4 BioGRID KRAS GeneID BioGRID Negative Genetic
GPX4 BioGRID EGFR GeneID BioGRID Negative Genetic
GPX4 BioGRID SNRNP48 GeneID BioGRID Two-hybrid
GPX4 BioGRID LHFPL4 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID DIABLO GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID CACFD1 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID GPA33 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID VCY GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID RPE GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID OMP GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID IL18 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID CYB561 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID CST6 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID CDA GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
GPX4 BioGRID POLR1G GeneID BioGRID Proximity Label-MS
GPX4 BioGRID COIL GeneID BioGRID Proximity Label-MS
GPX4 BioGRID HSCB GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID SPRING1 GeneID BioGRID Positive Genetic
GPX4 BioGRID KIF23 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID PPIB GeneID BioGRID Proximity Label-MS
GPX4 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID MTMR14 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID PTPN12 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID EYA4 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID PARK7 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
GPX4 BioGRID UBE2M GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID HHV8GK18_gp78 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
GPX4 BioGRID GSTO2 GeneID BioGRID Affinity Capture-MS
GPX4 BioGRID CEP170 GeneID BioGRID Proximity Label-MS
GPX4 BioGRID PGAM4 GeneID BioGRID Co-fractionation
GPX4 BioGRID ERO1B GeneID BioGRID Co-fractionation
GPX4 BioGRID GLRX2 GeneID BioGRID Co-fractionation
GPX4 BioGRID STIP1 GeneID BioGRID Co-fractionation
GPX4 BioGRID NUTF2 GeneID BioGRID Co-fractionation
GPX4 BioGRID PPIF GeneID BioGRID Co-fractionation
GPX4 BioGRID PRDX6 GeneID BioGRID Co-fractionation; Two-hybrid
GPX4 BioGRID TAGLN2 GeneID BioGRID Co-fractionation
GPX4 BioGRID EZR GeneID BioGRID Co-fractionation
GPX4 BioGRID VDAC2 GeneID BioGRID Co-fractionation
GPX4 BioGRID VDAC1 GeneID BioGRID Co-fractionation
GPX4 BioGRID UCHL3 GeneID BioGRID Co-fractionation
GPX4 BioGRID TKT GeneID BioGRID Co-fractionation
GPX4 BioGRID PRDX2 GeneID BioGRID Co-fractionation
GPX4 BioGRID TAGLN GeneID BioGRID Co-fractionation
GPX4 BioGRID SOD2 GeneID BioGRID Co-fractionation
GPX4 BioGRID SOD1 GeneID BioGRID Co-fractionation
GPX4 BioGRID PIN1 GeneID BioGRID Co-fractionation
GPX4 BioGRID ME1 GeneID BioGRID Co-fractionation
GPX4 BioGRID IMPA2 GeneID BioGRID Co-fractionation
GPX4 BioGRID HSPE1 GeneID BioGRID Co-fractionation
GPX4 BioGRID HINT1 GeneID BioGRID Co-fractionation
GPX4 BioGRID HSD17B10 GeneID BioGRID Co-fractionation
GPX4 BioGRID FKBP2 GeneID BioGRID Co-fractionation
GPX4 BioGRID FKBP1A GeneID BioGRID Co-fractionation
GPX4 BioGRID ETFB GeneID BioGRID Co-fractionation
GPX4 BioGRID ETFA GeneID BioGRID Co-fractionation
GPX4 BioGRID ENO3 GeneID BioGRID Co-fractionation
GPX4 BioGRID ENO2 GeneID BioGRID Co-fractionation
GPX4 BioGRID ENO1 GeneID BioGRID Co-fractionation
GPX4 BioGRID DUT GeneID BioGRID Co-fractionation
GPX4 BioGRID AKR1B1 GeneID BioGRID Co-fractionation
GPX4 BioGRID ALDOC GeneID BioGRID Co-fractionation
GPX4 BioGRID ALDOA GeneID BioGRID Co-fractionation
GPX4 BioGRID MAPK13 GeneID BioGRID Two-hybrid
GPX4 BioGRID OTUD5 GeneID BioGRID Affinity Capture-MS
StringDB
A B experiments database textmining combined score hadb nhadb
GPX4 FH 0 0 180 232 1 1
GPX4 NDUFA13 0 0 0 208 1 1
GPX4 TXN 0 0 565 865 1 1
GPX4 ALDH5A1 0 0 0 357 1 1
GPX4 AOX1 0 0 150 203 1 1
GPX4 SSBP1 0 0 57 166 1 1
GPX4 GCH1 0 0 113 189 1 1
GPX4 SLC17A5 0 0 49 188 1 1
GPX4 FADS2 0 0 204 220 1 1
GPX4 HPGD 0 0 0 155 1 1
GPX4 CAT 0 0 651 920 1 2
GPX4 ATP5J 0 0 94 156 1 1
GPX4 ARID4A 0 0 57 240 1 1
GPX4 MT1F 0 0 0 159 1 1
GPX4 THEG 0 0 150 155 1 1
GPX4 NDUFA10 0 0 88 202 1 1
GPX4 GSTT2B 0 650 218 749 1 1
GPX4 RIMKLB 0 0 0 159 1 1
GPX4 CYC1 0 0 87 177 1 1
GPX4 LPCAT3 0 0 519 522 1 1
GPX4 SEP15 0 0 705 777 1 1
GPX4 TPRKB 0 0 0 187 1 1
GPX4 DNAJB2 0 0 54 175 1 1
GPX4 MTRF1L 0 0 74 192 1 1
GPX4 PBDC1 0 0 0 186 1 1
GPX4 DNAJB12 0 0 73 156 1 1
GPX4 ATF7 0 0 0 253 1 1
GPX4 FDFT1 0 0 228 242 1 1
GPX4 KIF23 270 0 0 270 1 1
GPX4 HPRT1 0 0 183 231 1 1
GPX4 PHLPP2 0 0 0 155 1 1
GPX4 EEF1E1 0 0 0 159 1 1
GPX4 FOXA2 0 0 60 169 1 1
GPX4 AKR1C1 0 0 160 237 1 1
GPX4 TMX3 0 0 0 250 1 1
GPX4 ANXA2 0 0 94 151 1 1
GPX4 ATP6V1F 0 0 0 167 1 1
GPX4 NCF1 0 0 233 388 1 1
GPX4 HK3 0 0 0 189 1 1
GPX4 PSTK 0 0 325 390 1 1
GPX4 TXNDC11 0 0 0 194 1 1
GPX4 GGTLC1 0 0 124 198 1 1
GPX4 MTHFR 0 0 120 213 1 1
GPX4 ALDH2 0 0 167 272 1 2
GPX4 ALDOC 272 0 45 335 1 1
GPX4 CCND1 0 0 107 152 1 2
GPX4 FSHR 0 0 140 174 1 1
GPX4 HSF2 0 0 0 210 1 1
GPX4 CCDC178 0 0 155 154 1 1
GPX4 MT1A 0 0 134 240 1 1
GPX4 NOS3 0 0 193 274 1 2
GPX4 PC 0 0 52 204 1 1
GPX4 RRM2B 0 0 150 196 1 1
GPX4 STAR 0 0 122 161 1 1
GPX4 BAD 0 0 92 193 1 2
GPX4 SLCO2B1 0 0 0 188 1 1
GPX4 TXNRD3NB 0 0 260 260 1 1
GPX4 PDHB 0 0 88 175 1 1
GPX4 AHR 0 0 103 192 1 2
GPX4 TOM1L2 0 0 70 170 1 1
GPX4 GSTA1 0 650 334 813 1 1
GPX4 NOX5 0 0 174 426 1 1
GPX4 HSPA9 0 0 155 211 1 1
GPX4 CHCHD4 0 0 157 409 1 1
GPX4 IRS1 0 0 97 187 1 2
GPX4 LOX 0 0 391 408 1 2
GPX4 PLSCR2 0 0 0 151 1 1
GPX4 CYLC1 0 0 113 168 1 1
GPX4 ATOX1 0 0 181 226 1 1
GPX4 RTN4IP1 0 0 0 355 1 1
GPX4 PKM 0 0 114 165 1 1
GPX4 GADD45A 0 0 150 242 1 1
GPX4 GSTM5 0 650 396 824 1 1
GPX4 CCT2 0 0 137 178 1 1
GPX4 CD6 0 0 0 189 1 1
GPX4 PGK2 0 0 166 215 1 1
GPX4 MAPK1 0 0 66 292 1 2
GPX4 NDUFV1 0 0 206 381 1 1
GPX4 IGF1 0 0 143 328 1 2
GPX4 ALDH9A1 0 0 47 167 1 1
GPX4 PLA2G3 0 0 0 212 1 1
GPX4 MMP27 0 0 0 156 1 1
GPX4 FHIT 0 0 0 156 1 1
GPX4 PRDX2 272 0 504 840 1 1
GPX4 PYCR2 0 0 0 155 1 1
GPX4 TFRC 0 0 394 394 1 1
GPX4 GOT1L1 0 0 0 272 1 1
GPX4 CYB5R3 0 0 66 176 1 1
GPX4 GSTP1 0 650 394 822 1 1
GPX4 ERAP2 0 0 0 151 1 1
GPX4 IREB2 0 0 391 422 1 1
GPX4 PRDX4 0 0 460 768 1 1
GPX4 CYP2A6 0 0 0 157 1 1
GPX4 GLRX2 272 0 519 850 1 1
GPX4 BCAP31 0 0 0 363 1 1
GPX4 RPL7A 0 0 0 214 1 1
GPX4 SLC17A9 0 0 0 181 1 1
GPX4 MMP8 0 0 0 158 1 1
GPX4 PTGES3L 0 0 0 163 1 1
GPX4 TXNIP 0 0 218 235 1 2
GPX4 SLC17A8 0 0 0 181 1 1
GPX4 PLEKHA4 270 0 0 270 1 1
GPX4 NDUFA7 0 0 81 202 1 1
GPX4 ACADM 0 0 161 161 1 1
GPX4 FIS1 0 0 143 349 1 2
GPX4 MUTYH 0 0 123 177 1 1
GPX4 MIDN 0 0 182 181 1 1
GPX4 ALDH18A1 0 0 95 300 1 1
GPX4 GLS2 0 0 303 308 1 1
GPX4 ALDH7A1 0 0 90 155 1 1
GPX4 GGT7 0 900 225 926 1 1
GPX4 PEBP1 0 0 282 354 1 1
GPX4 CBSL 0 0 139 337 1 1
GPX4 AP3S1 0 0 0 187 1 1
GPX4 MT2A 0 0 160 328 1 1
GPX4 STIP1 272 0 0 336 1 1
GPX4 SLC7A11 0 0 689 713 1 2
GPX4 NXNL1 0 0 0 162 1 1
GPX4 MDH1 0 0 66 182 1 1
GPX4 SLC16A2 0 0 48 317 1 1
GPX4 ASCL4 0 0 294 295 1 1
GPX4 TNF 0 0 324 539 1 2
GPX4 TCN2 0 0 111 158 1 1
GPX4 XDH 0 0 155 207 1 1
GPX4 UQCRC1 0 0 212 299 1 1
GPX4 HSPA2 0 0 93 300 1 1
GPX4 GFER 0 0 82 204 1 1
GPX4 MMP25 0 0 0 153 1 1
GPX4 MT1X 0 0 0 233 1 1
GPX4 BDNF 0 0 107 201 1 2
GPX4 CASP2 0 0 81 183 1 1
GPX4 UCP3 0 0 210 307 1 1
GPX4 ECHDC2 0 0 0 154 1 1
GPX4 MMP3 0 0 0 188 1 1
GPX4 KCNAB2 0 0 0 191 1 1
GPX4 PSMD8 0 0 0 161 1 1
GPX4 ATF6 0 0 120 158 1 2
GPX4 CARS2 0 0 290 334 1 1
GPX4 SECISBP2L 0 0 212 230 1 1
GPX4 GSTM1 0 650 335 807 1 1
GPX4 SLC2A5 0 0 61 164 1 1
GPX4 DUOX1 0 0 272 538 1 1
GPX4 CYP2A7 0 0 0 157 1 1
GPX4 CST3 0 0 62 176 1 1
GPX4 NOX4 0 0 370 541 1 2
GPX4 PHKG2 0 0 249 265 1 1
GPX4 EDF1 0 0 0 276 1 1
GPX4 AKT1 0 0 266 407 1 2
GPX4 TYSND1 0 0 0 202 1 1
GPX4 SERF2 0 0 0 152 1 1
GPX4 PPARG 0 0 252 344 1 2
GPX4 MRPS31 0 0 0 188 1 1
GPX4 AP2M1 0 0 0 151 1 1
GPX4 GGT1 0 900 217 925 1 1
GPX4 NDUFA5 0 0 160 257 1 1
GPX4 CLPP 0 0 61 230 1 1
GPX4 SEPW1 0 0 740 788 1 1
GPX4 SEPHS2 0 0 689 742 1 1
GPX4 FOXA1 0 0 0 152 1 1
GPX4 CIRBP 0 0 177 210 1 1
GPX4 ISCU 0 0 161 361 1 1
GPX4 ATF4 0 0 235 249 1 2
GPX4 UQCRFS1 0 0 232 265 1 1
GPX4 VCAM1 0 0 97 210 1 1
GPX4 ATF1 0 0 73 157 1 1
GPX4 CYP2J2 0 0 0 157 1 1
GPX4 GSTA2 0 650 243 788 1 1
GPX4 SQRDL 0 0 95 170 1 1
GPX4 PHYKPL 0 0 0 201 1 1
GPX4 AIFM1 0 0 139 336 1 1
GPX4 NDUFB10 0 0 123 173 1 1
GPX4 PRDX3 0 0 566 813 1 1
GPX4 ENSG00000274276 0 0 139 337 1 1
GPX4 DHODH 0 0 69 251 1 1
GPX4 PILRB 0 0 144 150 1 1
GPX4 CTSC 0 0 0 190 1 1
GPX4 CYP2C19 0 0 48 164 1 1
GPX4 TH 0 0 150 281 1 2
GPX4 GPT 0 0 214 263 1 1
GPX4 SEPP1 0 0 800 816 1 1
GPX4 MYOF 0 0 681 681 1 1
GPX4 PINK1 0 0 165 361 1 2
GPX4 GSK3A 0 0 0 157 1 1
GPX4 TCEB2 0 0 0 169 1 1
GPX4 BIRC5 270 0 73 308 1 2
GPX4 NDUFB3 0 0 142 178 1 1
GPX4 SIRT4 0 0 167 230 1 1
GPX4 HIBCH 0 0 67 222 1 1
GPX4 KCNAB1 0 0 0 185 1 1
GPX4 DLD 0 0 108 269 1 2
GPX4 FOXO4 0 0 95 215 1 1
GPX4 HSP90AB1 0 0 74 234 1 2
GPX4 RNF7 0 0 57 178 1 1
GPX4 MAFG 0 0 108 163 1 1
GPX4 TRIM28 0 0 49 181 1 2
GPX4 SUOX 0 0 84 332 1 1
GPX4 PLSCR1 0 0 0 151 1 1
GPX4 MIF 0 0 75 200 1 2
GPX4 SLC25A39 0 0 74 154 1 1
GPX4 DNAJB1 0 0 160 344 1 2
GPX4 PSMB5 0 0 108 214 1 1
GPX4 COASY 0 0 229 271 1 1
GPX4 TXNDC9 0 0 100 244 1 1
GPX4 GPATCH2 0 0 391 390 1 1
GPX4 EPT1 0 0 601 640 1 1
GPX4 EIF2AK3 0 0 176 175 1 2
GPX4 HNF4A 0 0 447 447 1 1
GPX4 COMT 0 0 129 256 1 1
GPX4 A2M 0 0 81 162 1 1
GPX4 SRXN1 0 0 284 666 1 1
GPX4 FMO2 0 0 137 176 1 1
GPX4 RTN3 0 0 67 181 1 1
GPX4 MB 0 0 165 194 1 2
GPX4 APOE 0 0 241 288 1 2
GPX4 PCSK9 0 0 62 164 1 1
GPX4 VDAC3 0 0 391 414 1 1
GPX4 SLC2A4 0 0 122 267 1 1
GPX4 METTL3 0 0 0 207 1 2
GPX4 FOXO3 0 0 167 512 1 2
GPX4 SRC 0 0 137 161 1 2
GPX4 ATP5J2 0 0 0 190 1 1
GPX4 EED 0 0 0 181 1 1
GPX4 VIMP 0 0 708 722 1 1
GPX4 SCD 0 0 208 264 1 1
GPX4 HP 0 0 81 174 1 1
GPX4 GPX6 0 0 720 337 1 1
GPX4 SARS2 0 0 132 194 1 2
GPX4 LRP8 0 0 286 305 1 1
GPX4 SLC16A10 0 0 0 205 1 1
GPX4 GLUL 0 0 142 304 1 1
GPX4 GHITM 0 0 67 166 1 1
GPX4 PIGO 0 0 0 317 1 1
GPX4 ATP5C1 0 0 73 163 1 1
GPX4 PIK3C2A 0 0 0 216 1 1
GPX4 VDAC1 272 0 376 543 1 2
GPX4 ESD 0 0 61 160 1 1
GPX4 RIPK3 0 0 427 444 1 2
GPX4 GSTA3 0 650 293 802 1 1
GPX4 GSTM4 0 650 63 756 1 1
GPX4 DHCR24 0 0 166 217 1 1
GPX4 DIO2 0 0 563 660 1 1
GPX4 GSTZ1 0 0 150 342 1 1
GPX4 CYP2D6 0 0 0 157 1 1
GPX4 MDH2 0 0 155 224 1 1
GPX4 HMOX1 0 0 517 788 1 2
GPX4 PYCRL 0 0 0 305 1 1
GPX4 MGST1 0 650 167 735 1 1
GPX4 SLC17A7 0 0 0 181 1 1
GPX4 ATP5H 0 0 134 229 1 1
GPX4 GLRX 0 0 556 751 1 1
GPX4 TRIT1 0 0 260 273 1 1
GPX4 TBPL2 0 0 0 151 1 1
GPX4 LYST 0 0 0 189 1 1
GPX4 CYP2C9 0 0 42 158 1 1
GPX4 EIF2S1 0 0 138 153 1 2
GPX4 NDUFA1 0 0 212 253 1 1
GPX4 ANPEP 0 0 74 178 1 1
GPX4 LDHB 0 0 71 244 1 1
GPX4 OXR1 0 0 66 230 1 1
GPX4 H6PD 0 0 63 289 1 1
GPX4 CASP3 0 0 414 632 1 2
GPX4 PDIA6 0 0 60 232 1 1
GPX4 PRM2 0 0 208 226 1 1
GPX4 C7orf61 0 0 166 165 1 1
GPX4 NQO1 0 0 459 583 1 2
GPX4 EEF1A1 0 0 138 161 1 1
GPX4 PTGS2 0 0 358 480 1 2
GPX4 ADPRM 0 0 117 155 1 1
GPX4 ZAR1L 0 0 142 184 1 1
GPX4 RGN 0 0 67 285 1 1
GPX4 AFP 0 0 0 261 1 2
GPX4 PLA2G6 0 0 147 203 1 1
GPX4 PSMB6 0 0 67 169 1 1
GPX4 HSPA1B 0 0 107 310 1 1
GPX4 DBI 0 0 75 153 1 1
GPX4 NLRP3 0 0 145 183 1 2
GPX4 MIEN1 0 0 137 272 1 1
GPX4 MT1H 0 0 0 159 1 1
GPX4 ENSG00000268643 0 0 0 157 1 1
GPX4 HELLS 0 0 151 150 1 1
GPX4 COX6A1 0 0 180 245 1 1
GPX4 CRYM 0 0 46 251 1 1
GPX4 CYBB 0 0 340 514 1 2
GPX4 MRPL55 0 0 0 179 1 1
GPX4 STS 0 0 0 250 1 1
GPX4 SLC1A1 0 0 95 170 1 1
GPX4 REN 0 0 96 200 1 1
GPX4 ZP2 297 0 0 297 1 1
GPX4 TNP2 0 0 112 173 1 1
GPX4 HSPA4L 0 0 97 161 1 1
GPX4 ALOX5 0 0 365 372 1 1
GPX4 ACE 0 0 74 171 1 1
GPX4 NME9 0 0 0 344 1 1
GPX4 CUL3 0 0 150 315 1 2
GPX4 HPX 0 0 113 153 1 1
GPX4 NDUFS8 0 0 174 270 1 1
GPX4 SCLY 0 0 408 420 1 1
GPX4 GSK3B 0 0 96 207 1 2
GPX4 RPS15 0 0 87 195 1 1
GPX4 SPATC1 0 0 261 271 1 1
GPX4 GPX8 0 0 653 218 1 1
GPX4 FABP4 0 0 120 186 1 1
GPX4 CHAC2 0 900 0 902 1 1
GPX4 RIPK1 0 0 395 408 1 2
GPX4 RRM2 0 0 108 162 1 1
GPX4 MSRB1 0 0 683 742 1 1
GPX4 CKB 0 0 89 160 1 1
GPX4 PTGES3 0 0 74 271 1 1
GPX4 ACO1 0 0 261 299 1 1
GPX4 ETFB 272 0 0 291 1 1
GPX4 ZDHHC6 0 0 160 175 1 1
GPX4 LDHAL6B 0 0 0 178 1 1
GPX4 TXNRD2 0 0 707 852 1 1
GPX4 PDILT 0 0 0 200 1 1
GPX4 ERO1LB 272 0 123 523 1 1
GPX4 GPI 0 0 67 460 1 2
GPX4 PIK3CD 0 0 0 200 1 1
GPX4 MT-CO2 0 0 59 240 1 1
GPX4 TXNRD1 0 0 739 904 1 1
GPX4 CDO1 0 0 217 217 1 1
GPX4 TSPO 0 0 42 183 1 1
GPX4 PDIA4 0 0 66 232 1 1
GPX4 FBP1 0 0 0 226 1 1
GPX4 PON1 0 0 139 213 1 1
GPX4 PRKAR1A 0 0 66 156 1 2
GPX4 CYP3A43 0 0 0 150 1 1
GPX4 SOD2 408 0 602 926 1 2
GPX4 CYP2A13 0 0 0 157 1 1
GPX4 GPX2 0 500 803 620 1 1
GPX4 MECR 0 0 0 270 1 1
GPX4 TKT 272 0 113 358 1 1
GPX4 TAGLN2 272 0 0 283 1 1
GPX4 KRAS 0 0 169 238 1 2
GPX4 PGD 0 0 0 182 1 1
GPX4 UEVLD 0 0 107 194 1 1
GPX4 FOXO1 0 0 185 241 1 2
GPX4 RAI14 0 0 67 181 1 1
GPX4 FTH1 0 0 459 497 1 1
GPX4 PIGL 0 0 72 171 1 1
GPX4 RABAC1 0 0 0 187 1 1
GPX4 ENSG00000257767 0 0 0 164 1 1
GPX4 GDPD2 0 0 0 157 1 1
GPX4 NRAS 0 0 82 158 1 1
GPX4 AKR1A1 0 0 0 238 1 1
GPX4 HSPA5 0 0 285 406 1 2
GPX4 PHB 0 0 108 290 1 1
GPX4 MAPK11 0 0 57 287 1 1
GPX4 SNRNP25 0 0 0 170 1 1
GPX4 PMAIP1 0 0 124 178 1 2
GPX4 AUH 0 0 142 343 1 1
GPX4 LRP2 0 0 166 172 1 1
GPX4 DNAJC10 0 0 0 411 1 1
GPX4 PIK3CB 0 0 0 306 1 1
GPX4 DNAJB6 0 0 74 157 1 1
GPX4 IL2 0 0 97 161 1 1
GPX4 OLR1 0 0 66 163 1 2
GPX4 ALDH1A1 0 0 124 234 1 1
GPX4 COX4I2 0 0 181 246 1 1
GPX4 ABCC1 0 0 124 178 1 1
GPX4 BECN1 0 0 211 228 1 2
GPX4 EEF1G 0 0 92 279 1 1
GPX4 MAOB 0 0 76 209 1 1
GPX4 PGLS 0 0 0 217 1 1
GPX4 TMX4 0 0 0 176 1 1
GPX4 PTGES 0 0 194 218 1 1
GPX4 ENSG00000262660 0 0 181 222 1 1
GPX4 ENSG00000259040 0 0 0 200 1 1
GPX4 UGP2 0 0 108 170 1 1
GPX4 CLIC1 0 0 49 158 1 1
GPX4 GSS 0 900 48 944 1 1
GPX4 PDIA3 0 0 77 315 1 1
GPX4 EEFSEC 0 0 525 574 1 1
GPX4 CCT6B 0 0 113 155 1 1
GPX4 SLC40A1 0 0 340 365 1 1
GPX4 DCBLD1 0 0 0 191 1 1
GPX4 PARP2 0 0 143 196 1 1
GPX4 GSTM2 0 650 267 776 1 1
GPX4 SPATA19 0 0 108 151 1 1
GPX4 LDHC 0 0 61 190 1 1
GPX4 SELO 0 0 659 720 1 1
GPX4 ERCC6 0 0 108 163 1 1
GPX4 NDUFA2 0 0 166 252 1 1
GPX4 YIPF1 0 0 0 355 1 1
GPX4 SLC17A2 0 0 0 181 1 1
GPX4 ATG5 0 0 206 206 1 2
GPX4 SELT 0 0 710 785 1 1
GPX4 EPHX1 0 0 102 253 1 1
GPX4 ACTRT2 0 0 108 174 1 1
GPX4 SEPN1 0 0 684 712 1 1
GPX4 MT1G 0 0 260 351 1 1
GPX4 SLC22A5 0 0 108 157 1 1
GPX4 PUM1 0 0 53 164 1 1
GPX4 CAPNS1 0 0 66 250 1 2
GPX4 PDIA5 0 0 55 212 1 1
GPX4 SIRT1 0 0 240 551 1 2
GPX4 NOX1 0 0 374 539 1 1
GPX4 CTSB 0 0 170 205 1 2
GPX4 ESR1 0 0 167 202 1 2
GPX4 TXNDC5 0 0 74 228 1 1
GPX4 NCL 0 0 124 164 1 2
GPX4 DUOX2 0 0 181 480 1 1
GPX4 HMGB1 0 0 139 156 1 2
GPX4 PPP1CA 0 0 0 152 1 1
GPX4 BACE1 0 0 123 182 1 2
GPX4 DIO3 0 0 518 609 1 1
GPX4 MAP3K5 0 0 260 291 1 1
GPX4 ABRA 0 0 102 152 1 1
GPX4 HINT1 605 0 0 664 1 1
GPX4 SOD3 0 0 451 634 1 1
GPX4 GPX3 0 0 804 308 1 1
GPX4 AKT3 0 0 0 225 1 2
GPX4 MS4A15 0 0 181 198 1 1
GPX4 DIO1 0 0 257 332 1 1
GPX4 GPX1 0 500 870 655 1 1
GPX4 MT-CYB 0 0 161 179 1 1
GPX4 MT-CO1 0 0 108 251 1 1
GPX4 TBP 0 0 81 274 1 1
GPX4 AP2S1 0 0 0 232 1 1
GPX4 PCBP1 0 0 155 173 1 1
GPX4 GDE1 0 0 0 157 1 1
GPX4 HSPB2 0 0 134 176 1 1
GPX4 HIGD2A 0 0 0 163 1 1
GPX4 EPX 0 0 0 290 1 1
GPX4 NCF2 0 0 155 286 1 1
GPX4 HSPB1 0 0 277 312 1 2
GPX4 NDUFA8 0 0 155 237 1 1
GPX4 CST4 0 0 125 165 1 1
GPX4 HMOX2 0 0 90 516 1 1
GPX4 SARS 0 0 144 238 1 1
GPX4 NDUFB8 0 0 67 199 1 1
GPX4 MAP1LC3B 0 0 194 246 1 2
GPX4 ERP27 0 0 0 200 1 1
GPX4 SH3BGRL3 0 0 155 205 1 1
GPX4 TRNAU1AP 0 0 400 458 1 1
GPX4 MDH1B 0 0 0 160 1 1
GPX4 CYP2C8 0 0 0 157 1 1
GPX4 ACTG1 0 0 208 259 1 1
GPX4 ATG7 0 0 186 214 1 2
GPX4 PTGR1 0 0 69 175 1 1
GPX4 IL10 0 0 170 321 1 2
GPX4 GSTA5 0 650 83 743 1 1
GPX4 METTL15 0 0 0 221 1 1
GPX4 UQCR11 0 0 122 256 1 1
GPX4 SLC17A1 0 0 0 181 1 1
GPX4 EZR 272 0 0 272 1 1
GPX4 ATM 0 0 142 195 1 2
GPX4 IDH2 0 0 151 223 1 1
GPX4 PON2 0 0 134 188 1 1
GPX4 CYGB 0 0 89 181 1 1
GPX4 BCAP29 0 0 0 793 1 1
GPX4 ALDH1B1 0 0 47 167 1 1
GPX4 GOT2 0 0 66 660 1 1
GPX4 ENG 0 0 0 303 1 2
GPX4 LHCGR 0 0 169 186 1 1
GPX4 DNAJB13 0 0 0 251 1 1
GPX4 TXNDC17 0 0 108 204 1 1
GPX4 G6PD 0 0 255 575 1 1
GPX4 STEAP1 0 0 180 179 1 1
GPX4 LEP 0 0 125 313 1 1
GPX4 UBE2M 270 0 62 322 1 1
GPX4 HFE 0 0 134 183 1 1
GPX4 B3GALNT1 0 0 82 151 1 1
GPX4 PNMAL2 0 0 0 151 1 1
GPX4 NFE2L1 0 0 54 362 1 1
GPX4 C12orf5 0 0 150 190 1 1
GPX4 CLPB 0 0 0 277 1 1
GPX4 LDHA 0 0 162 318 1 2
GPX4 COX8A 0 0 74 214 1 1
GPX4 FKBP2 684 0 0 698 1 1
GPX4 UCP1 0 0 82 160 1 2
GPX4 SREBF1 0 0 193 199 1 1
GPX4 ZP4 297 0 0 297 1 1
GPX4 AKR7A2 0 0 91 181 1 1
GPX4 MAPK14 0 0 74 300 1 2
GPX4 OVGP1 0 0 234 240 1 1
GPX4 TXNDC2 0 0 63 360 1 1
GPX4 YARS 0 0 0 173 1 1
GPX4 DAK 0 0 0 187 1 1
GPX4 FTL 0 0 390 471 1 1
GPX4 PTEN 0 0 166 218 1 2
GPX4 TXN2 0 0 594 673 1 1
GPX4 MAPK7 0 0 0 266 1 1
GPX4 ACSL4 0 0 681 681 1 1
GPX4 NUTF2 272 0 0 293 1 1
GPX4 VEGFA 0 0 181 186 1 2
GPX4 MMP11 0 0 49 161 1 1
GPX4 NME8 0 0 45 350 1 1
GPX4 SLC39A14 0 0 204 208 1 1
GPX4 NUDT1 0 0 143 161 1 1
GPX4 GAPDHS 0 0 119 365 1 1
GPX4 DNM1L 0 0 171 222 1 2
GPX4 STAT3 0 0 161 197 1 2
GPX4 HAGH 0 0 96 261 1 1
GPX4 PLIN4 0 0 94 279 1 1
GPX4 TMPPE 0 0 93 165 1 1
GPX4 VDAC2 272 0 450 598 1 1
GPX4 HMHA1 0 0 137 160 1 1
GPX4 EIF2AK4 0 0 117 159 1 2
GPX4 EXOSC10 0 0 0 177 1 1
GPX4 MSRB3 0 0 140 363 1 1
GPX4 NDUFS1 0 0 182 219 1 1
GPX4 TXNDC8 0 0 0 344 1 1
GPX4 MMP15 0 0 0 153 1 1
GPX4 GLRX5 0 0 260 560 1 1
GPX4 AKR1B15 0 0 0 241 1 1
GPX4 PYCR1 0 0 0 155 1 1
GPX4 GCLM 0 0 469 594 1 1
GPX4 CYBRD1 0 0 156 155 1 1
GPX4 FREM2 0 0 0 155 1 1
GPX4 MGST2 0 650 82 664 1 1
GPX4 APRT 0 0 0 219 1 1
GPX4 SNRPD1 0 0 0 213 1 2
GPX4 ALDH1L2 0 0 96 186 1 1
GPX4 GSTK1 0 0 413 476 1 1
GPX4 PIN1 272 0 0 297 1 1
GPX4 CYBA 0 0 275 427 1 1
GPX4 PYROXD2 0 0 0 265 1 1
GPX4 ADH1C 0 0 140 193 1 1
GPX4 HSCB 270 0 0 290 1 1
GPX4 APAF1 0 0 180 277 1 2
GPX4 RBM3 0 0 91 350 1 1
GPX4 RNF126 0 0 134 155 1 1
GPX4 C19orf24 0 0 156 198 1 1
GPX4 MCAT 0 0 180 203 1 1
GPX4 EDA 0 0 0 167 1 1
GPX4 LIPN 0 0 49 213 1 1
GPX4 PRKACG 0 0 0 156 1 1
GPX4 C6orf57 275 0 0 275 1 1
GPX4 SLC25A4 0 0 108 169 1 1
GPX4 PRKX 0 0 96 204 1 1
GPX4 KPNA3 0 0 0 175 1 1
GPX4 CHPT1 0 0 90 253 1 1
GPX4 DDIT3 0 0 167 225 1 2
GPX4 SLC7A5 0 0 74 176 1 1
GPX4 HK2 0 0 103 305 1 2
GPX4 ACSL6 0 0 243 276 1 1
GPX4 RPL36 0 0 0 171 1 1
GPX4 EGFR 0 0 193 193 1 2
GPX4 CCS 0 0 218 266 1 2
GPX4 OPLAH 0 0 284 299 1 1
GPX4 HTT 0 0 75 169 1 2
GPX4 LACTB 275 0 0 275 1 1
GPX4 MARS 0 0 0 168 1 1
GPX4 FADD 0 0 171 189 1 2
GPX4 C11orf31 0 0 710 710 1 1
GPX4 GK2 0 0 125 194 1 1
GPX4 SLC2A1 0 0 143 200 1 2
GPX4 DECR1 0 0 113 153 1 1
GPX4 ZNF143 0 0 150 215 1 1
GPX4 TALDO1 0 0 70 228 1 1
GPX4 KPNA4 0 0 0 177 1 1
GPX4 UBIAD1 0 0 0 159 1 1
GPX4 TP53 0 0 421 425 1 2
GPX4 TXNL1 0 0 183 283 1 1
GPX4 MAOA 0 0 90 181 1 1
GPX4 ALOX15 0 0 686 686 1 1
GPX4 ODC1 0 0 96 253 1 1
GPX4 PPIF 312 0 261 501 1 1
GPX4 ALDH8A1 0 0 0 162 1 1
GPX4 GRSF1 0 0 950 950 1 1
GPX4 CHAC1 0 900 306 929 1 1
GPX4 AKT2 0 0 74 252 1 2
GPX4 EIF3G 0 0 0 198 1 1
GPX4 LNPEP 0 0 0 151 1 1
GPX4 SEC14L2 0 0 170 219 1 1
GPX4 CYP3A7 0 0 0 150 1 1
GPX4 PGAM5 0 0 161 181 1 1
GPX4 NFE2L2 0 0 520 700 1 2
GPX4 NCOA7 0 0 0 210 1 1
GPX4 FXN 0 0 175 273 1 1
GPX4 NDUFS3 0 0 150 207 1 1
GPX4 ANAPC11 0 0 0 224 1 1
GPX4 TFR2 0 0 166 165 1 1
GPX4 NOXA1 0 0 94 150 1 1
GPX4 XRCC3 0 0 0 169 1 1
GPX4 PARK7 270 0 335 646 1 2
GPX4 ACSL1 0 0 134 173 1 1
GPX4 NDUFB7 0 0 0 174 1 1
GPX4 HSD17B10 272 0 0 315 1 1
GPX4 SLC25A47 0 0 122 264 1 1
GPX4 ALOX12 0 0 293 293 1 1
GPX4 COX7A2 0 0 48 240 1 1
GPX4 ALOX12B 0 0 183 214 1 1
GPX4 SLC2A3 0 0 90 151 1 1
GPX4 MMP17 0 0 0 158 1 1
GPX4 SBNO2 0 0 180 179 1 1
GPX4 CHST1 0 0 0 202 1 1
GPX4 TPI1 0 0 96 506 1 1
GPX4 POLM 0 0 0 153 1 1
GPX4 PIK3CA 0 0 48 206 1 2
GPX4 APOA1BP 0 0 0 334 1 1
GPX4 FBP2 0 0 0 226 1 1
GPX4 MSRA 0 0 261 621 1 1
GPX4 ATP5G3 0 0 127 180 1 1
GPX4 GLS 0 0 194 199 1 2
GPX4 P4HB 0 0 125 335 1 2
GPX4 GPX7 0 0 739 204 1 1
GPX4 PPARGC1A 0 0 282 308 1 2
GPX4 MT3 0 0 73 226 1 1
GPX4 GDPD1 0 0 0 229 1 1
GPX4 NDUFA11 0 0 92 161 1 1
GPX4 IGF1R 0 0 103 175 1 2
GPX4 PLTP 0 0 0 200 1 1
GPX4 DIRC2 0 0 141 159 1 1
GPX4 PARK2 0 0 140 327 1 1
GPX4 NDUFS6 0 0 139 268 1 1
GPX4 STEAP3 0 0 261 261 1 1
GPX4 IL18 0 0 123 165 1 2
GPX4 APEX1 0 0 134 175 1 1
GPX4 DGAT1 0 0 92 170 1 2
GPX4 WDR12 0 0 0 177 1 1
GPX4 UBE2H 0 0 0 157 1 1
GPX4 PPRC1 0 0 0 256 1 1
GPX4 PPP1R7 0 0 0 167 1 1
GPX4 MYC 0 0 194 209 1 2
GPX4 NOS2 0 0 175 273 1 2
GPX4 MAP2K7 0 0 145 164 1 1
GPX4 HAMP 0 0 284 284 1 1
GPX4 GRHPR 0 0 0 155 1 1
GPX4 PGAM4 272 0 0 313 1 1
GPX4 LSM12 0 0 0 343 1 1
GPX4 CYP1A1 0 0 156 606 1 2
GPX4 GSTO1 0 650 324 877 1 1
GPX4 GAPDH 0 0 392 594 1 2
GPX4 CCDC152 0 0 155 191 1 1
GPX4 SLC25A11 0 0 139 192 1 1
GPX4 TLR4 0 0 136 300 1 2
GPX4 MT1M 0 0 43 160 1 1
GPX4 ENO1 272 0 107 389 1 1
GPX4 NNT 0 0 241 385 1 1
GPX4 BCL2L1 0 0 212 275 1 2
GPX4 COX5B 0 0 71 188 1 1
GPX4 SLC17A4 0 0 0 181 1 1
GPX4 TRIM72 0 0 62 161 1 1
GPX4 ALDOA 272 0 132 431 1 1
GPX4 LONRF2 0 0 0 151 1 1
GPX4 CASP6 0 0 101 205 1 1
GPX4 TRMT112 0 0 0 189 1 1
GPX4 ALDH1A2 0 0 0 162 1 1
GPX4 PIK3R4 0 0 46 290 1 2
GPX4 GSTM3 0 650 234 897 1 1
GPX4 PTPLA 0 0 0 208 1 1
GPX4 ME1 272 0 62 336 1 1
GPX4 CABIN1 0 0 51 308 1 1
GPX4 HSF1 0 0 70 233 1 2
GPX4 KCNAB3 0 0 0 185 1 1
GPX4 ABAT 0 0 0 381 1 1
GPX4 PRDX6 278 0 425 834 1 1
GPX4 GSTO2 273 650 381 898 1 1
GPX4 EPO 0 0 97 245 1 2
GPX4 ETFA 272 0 0 299 1 1
GPX4 GPD1 0 0 0 234 1 1
GPX4 GSDMA 0 0 181 181 1 1
GPX4 SIRT2 0 0 183 242 1 2
GPX4 PRDX5 0 0 507 696 1 1
GPX4 SLC25A6 0 0 0 179 1 1
GPX4 TAGLN 593 0 0 613 1 1
GPX4 ALDH3B2 0 0 71 203 1 1
GPX4 HSPD1 0 0 94 170 1 1
GPX4 ODF3L2 0 0 135 181 1 1
GPX4 CS 0 0 166 221 1 1
GPX4 ANXA5 0 0 264 493 1 2
GPX4 GGT2 0 0 85 162 1 1
GPX4 AKR1B10 0 0 107 306 1 1
GPX4 ETNPPL 0 0 0 201 1 1
GPX4 CREB1 0 0 145 217 1 2
GPX4 GSDMD 0 0 297 297 1 2
GPX4 NOX3 0 0 183 398 1 1
GPX4 IFNG 0 0 101 178 1 2
GPX4 BIRC2 0 0 139 200 1 1
GPX4 COX5A 0 0 150 238 1 1
GPX4 NXNL2 0 0 0 162 1 1
GPX4 SLC25A10 0 0 181 228 1 1
GPX4 TNP1 0 0 151 242 1 1
GPX4 HSPA1L 0 0 54 270 1 1
GPX4 PPID 0 0 112 155 1 1
GPX4 PTGES3L-AARSD1 0 0 0 163 1 1
GPX4 CABS1 0 0 181 234 1 1
GPX4 SDHB 0 0 166 273 1 1
GPX4 LONP1 0 0 112 167 1 1
GPX4 ACO2 0 0 213 406 1 1
GPX4 NFE2 0 0 81 179 1 1
GPX4 PRKACA 0 0 0 156 1 1
GPX4 LDHAL6A 0 0 0 178 1 1
GPX4 ALDH3B1 0 0 97 188 1 1
GPX4 TNFRSF1A 0 0 158 158 1 1
GPX4 CYP2F1 0 0 60 174 1 1
GPX4 OCLN 0 0 112 213 1 1
GPX4 GGTLC3 0 0 89 166 1 1
GPX4 DNAJB4 0 0 0 251 1 1
GPX4 ENDOG 0 0 186 222 1 1
GPX4 FOXO6 0 0 62 158 1 1
GPX4 CYP2C18 0 0 0 157 1 1
GPX4 EPHX2 0 0 0 151 1 1
GPX4 IL6 0 0 284 470 1 2
GPX4 UCP2 0 0 271 411 1 2
GPX4 SLC17A3 0 0 0 181 1 1
GPX4 MPO 0 0 138 433 1 2
GPX4 E2F2 0 0 44 165 1 1
GPX4 KPNA1 0 0 0 150 1 1
GPX4 POTEF 0 0 213 254 1 1
GPX4 CARS 0 0 306 363 1 1
GPX4 PLSCR3 0 0 0 151 1 1
GPX4 CISD1 0 0 335 367 1 1
GPX4 MTOR 0 0 203 213 1 2
GPX4 ATP5D 0 0 113 311 1 1
GPX4 ATF7-NPFF 0 0 0 253 1 1
GPX4 RPL13A 0 0 112 177 1 1
GPX4 PTGS1 0 0 118 210 1 1
GPX4 VNN1 0 0 94 168 1 1
GPX4 PIDD1 0 0 108 153 1 1
GPX4 COQ9 0 0 115 151 1 1
GPX4 ERAP1 0 0 0 194 1 1
GPX4 KLC3 0 0 60 178 1 1
GPX4 ACSL5 0 0 183 207 1 1
GPX4 UQCRB 0 0 181 213 1 1
GPX4 XPO1 0 0 0 407 1 1
GPX4 ACSL3 0 0 211 211 1 1
GPX4 MFN2 0 0 160 217 1 2
GPX4 ACTRT3 0 0 117 277 1 1
GPX4 APP 0 0 165 251 1 2
GPX4 RETSAT 0 0 0 265 1 1
GPX4 CTNNB1 0 0 142 201 1 2
GPX4 AKR1C3 0 0 0 170 1 1
GPX4 HRAS 0 0 242 319 1 2
GPX4 ALOXE3 0 0 162 177 1 1
GPX4 SLC1A7 0 0 204 204 1 1
GPX4 NDUFS4 0 0 112 165 1 1
GPX4 RPL30 0 0 243 386 1 1
GPX4 COX6B1 0 0 123 241 1 1
GPX4 SELENBP1 0 0 287 306 1 1
GPX4 MAPK13 111 0 0 319 1 1
GPX4 CXCL8 0 0 166 291 1 2
GPX4 WDR76 0 0 195 195 1 1
GPX4 IL1B 0 0 298 373 1 2
GPX4 UQCRC2 0 0 170 188 1 1
GPX4 CNOT2 0 0 0 243 1 1
GPX4 MT4 0 0 67 451 1 1
GPX4 MT1E 0 0 0 233 1 1
GPX4 HIF1A 0 0 288 360 1 2
GPX4 EDN1 0 0 66 164 1 1
GPX4 SIRT5 0 0 180 213 1 1
GPX4 GCK 0 0 73 216 1 1
GPX4 SP100 0 0 53 153 1 1
GPX4 WRN 0 0 70 340 1 1
GPX4 C2CD4C 0 0 115 170 1 1
GPX4 HTRA2 0 0 140 195 1 1
GPX4 ENSG00000269035 0 0 0 162 1 1
GPX4 FTMT 0 0 112 154 1 1
GPX4 ATF2 0 0 54 263 1 1
GPX4 CRP 0 0 90 293 1 2
GPX4 COX4I1 0 0 217 341 1 1
GPX4 PDIA2 0 0 54 223 1 1
GPX4 PNPLA2 0 0 193 193 1 2
GPX4 HSP90AA1 0 0 276 401 1 2
GPX4 HPGDS 0 650 457 818 1 1
GPX4 RIMKLA 0 0 0 159 1 1
GPX4 B2M 0 0 112 152 1 1
GPX4 MMP9 0 0 120 241 1 2
GPX4 MTHFD1 0 0 113 174 1 1
GPX4 HSPE1 272 0 90 507 1 1
GPX4 KEAP1 0 0 505 704 1 2
GPX4 MAPK3 0 0 143 351 1 2
GPX4 YIPF2 0 0 0 244 1 1
GPX4 SIRT3 0 0 260 358 1 2
GPX4 ENO3 647 0 53 673 1 1
GPX4 GLO1 0 0 181 259 1 1
GPX4 SLC11A2 0 0 362 368 1 1
GPX4 CRYZ 0 0 266 313 1 1
GPX4 ATP5O 0 0 81 169 1 1
GPX4 MPND 0 0 143 163 1 1
GPX4 SQSTM1 0 0 212 238 1 2
GPX4 ARID4B 0 0 0 153 1 1
GPX4 DNAJB5 0 0 82 283 1 1
GPX4 INS 0 0 296 488 1 2
GPX4 ACTB 0 0 459 500 1 2
GPX4 ALDH3A1 0 0 95 186 1 1
GPX4 NDUFB11 0 0 63 178 1 1
GPX4 AARD 0 0 150 281 1 1
GPX4 RNASEK 0 0 0 155 1 1
GPX4 STARD4 0 0 124 168 1 1
GPX4 ENSG00000255835 0 0 0 155 1 1
GPX4 GOT1 0 0 134 666 1 1
GPX4 STUB1 0 0 74 221 1 2
GPX4 CD3D 0 0 0 208 1 1
GPX4 PLA2G1B 0 0 180 262 1 1
GPX4 IMMP2L 0 0 181 253 1 1
GPX4 BAX 0 0 202 202 1 2
GPX4 OAZ1 0 0 87 174 1 1
GPX4 ERP44 0 0 45 200 1 1
GPX4 CDKN1A 0 0 113 153 1 2
GPX4 BID 0 0 181 199 1 2
GPX4 HSPA8 0 0 57 272 1 2
GPX4 INSR 0 0 94 166 1 1
GPX4 GSR 0 900 653 987 1 1
GPX4 AR 0 0 125 177 1 2
GPX4 PARP1 0 0 208 279 1 2
GPX4 CCT4 0 0 134 175 1 1
GPX4 SIRT7 0 0 162 192 1 2
GPX4 SLC25A14 0 0 123 183 1 1
GPX4 NFS1 0 0 253 269 1 1
GPX4 ADH1B 0 0 150 203 1 1
GPX4 MLKL 0 0 451 463 1 2
GPX4 CYP2R1 0 0 0 157 1 1
GPX4 RPL8 0 0 156 239 1 1
GPX4 ADH7 0 0 112 167 1 1
GPX4 CYP2U1 0 0 0 157 1 1
GPX4 UMPS 0 0 74 159 1 1
GPX4 PIGC 0 0 0 177 1 1
GPX4 PRDX1 0 0 504 787 1 1
GPX4 TTPA 0 0 167 252 1 1
GPX4 TPP2 0 0 55 183 1 1
GPX4 LTA 0 0 0 538 1 1
GPX4 SOD1 272 0 636 918 1 2
GPX4 NCOA4 0 0 457 468 1 2
GPX4 AKR1C2 0 0 75 160 1 1
GPX4 RMND1 0 0 89 221 1 1
GPX4 NDUFA3 0 0 141 212 1 1
GPX4 PRKACB 0 0 0 156 1 1
GPX4 ATP5B 0 0 154 176 1 1
GPX4 TBXAS1 0 0 64 170 1 1
GPX4 MMP2 0 0 108 163 1 2
GPX4 TFAM 0 0 233 394 1 2
GPX4 SAT1 0 0 202 219 1 1
GPX4 ALOX15B 0 0 299 299 1 1
GPX4 NDUFB2 0 0 113 170 1 1
GPX4 ZP3 297 0 0 297 1 1
GPX4 CALR 0 0 82 192 1 1
GPX4 MNAT1 0 0 0 282 1 1
GPX4 SORD 0 0 88 171 1 1
GPX4 IRS2 0 0 145 163 1 1
GPX4 PUM2 0 0 0 153 1 1
GPX4 MFN1 0 0 108 171 1 2
GPX4 SELK 0 0 707 766 1 1
GPX4 PIK3CG 0 0 46 205 1 1
GPX4 BOK 0 0 90 185 1 1
GPX4 HIC1 0 0 90 160 1 1
GPX4 OGDH 0 0 123 160 1 1
GPX4 HSPA1A 0 0 161 352 1 1
GPX4 AIF1 0 0 137 167 1 2
GPX4 GSTA4 0 650 310 770 1 1
GPX4 NOS1 0 0 160 244 1 1
GPX4 CASP1 0 0 217 217 1 2
GPX4 CGRRF1 0 0 134 188 1 1
GPX4 SNCA 0 0 210 228 1 2
GPX4 ALDH1A3 0 0 0 162 1 2
GPX4 DNTT 0 0 137 333 1 1
GPX4 COPE 0 0 0 164 1 2
GPX4 ACSF2 0 0 238 256 1 1
GPX4 MT1HL1 0 0 0 159 1 1
GPX4 HEPH 0 0 183 260 1 1
GPX4 JUN 129 0 194 356 1 2
GPX4 BCS1L 0 0 102 157 1 1
GPX4 PXDN 0 0 123 192 1 1
GPX4 MAPK12 0 0 42 267 1 1
GPX4 DNAJA3 0 0 0 171 1 1
GPX4 KL 0 0 70 183 1 2
GPX4 DNAJC16 0 0 91 158 1 1
GPX4 SEPHS1 0 0 395 458 1 1
GPX4 MGST3 0 650 283 764 1 1
GPX4 MTHFD2 0 0 170 169 1 1
GPX4 NRF1 0 0 154 224 1 2
GPX4 R3HDM4 0 0 195 195 1 1
GPX4 BCL2L11 0 0 120 214 1 2
GPX4 GGTLC2 0 0 134 207 1 1
GPX4 SEPSECS 0 0 392 441 1 1
GPX4 NTHL1 0 0 48 154 1 1
GPX4 ACHE 0 0 97 450 1 2
GPX4 HSPE1-MOB4 0 0 0 315 1 1
GPX4 PPARA 0 0 217 332 1 2
GPX4 VARS 0 0 0 198 1 1
GPX4 GGT6 0 900 163 920 1 1
GPX4 CYP2E1 0 0 215 428 1 2
GPX4 HSP90B1 0 0 167 272 1 1
GPX4 ENSG00000266953 0 0 0 189 1 1
GPX4 TMX1 0 0 0 176 1 1
GPX4 PPIB 106 0 0 202 1 1
GPX4 TRIM35 0 0 66 165 1 1
GPX4 CYP1B1 0 0 113 487 1 1
GPX4 HSPA4 0 0 273 325 1 1
GPX4 PCSK1 0 0 373 402 1 1
GPX4 NDUFB9 0 0 125 251 1 1
GPX4 EIF4A3 0 0 240 265 1 1
GPX4 ATP5A1 0 0 134 208 1 1
GPX4 AKR1B1 572 0 115 678 1 1
GPX4 PRM3 0 0 62 203 1 1
GPX4 CXCL11 0 0 180 179 1 1
GPX4 OGG1 0 0 261 322 1 1
GPX4 CYCS 0 0 390 620 1 2
GPX4 GADD45B 0 0 139 173 1 1
GPX4 AIFM2 0 0 195 249 1 1
GPX4 ANXA13 0 0 0 160 1 1
GPX4 HK1 0 0 45 466 1 1
GPX4 TREH 0 0 53 220 1 1
GPX4 CASP9 0 0 217 454 1 2
GPX4 ENO2 603 0 57 632 1 1
GPX4 COX7C 0 0 62 150 1 1
GPX4 NUFIP1 0 0 150 173 1 1
GPX4 GLRX3 0 0 320 451 1 1
GPX4 GGT5 0 900 203 927 1 1
GPX4 PYGM 0 0 45 192 1 1
GPX4 GCLC 0 0 518 785 1 1
GPX4 MAPK8 0 0 134 193 1 2
GPX4 COX6A2 0 0 108 207 1 1
GPX4 ADIPOQ 0 0 108 317 1 2
GPX4 CMBL 0 0 81 155 1 2
GPX4 PTGIS 0 0 141 172 1 1
GPX4 SECISBP2 0 0 748 753 1 1
GPX4 NXN 0 0 134 243 1 1
GPX4 TXNRD3 0 0 736 736 1 1
GPX4 FKBP1A 639 0 0 646 1 2
GPX4 GPD1L 0 0 0 234 1 1
GPX4 GDPD5 0 0 0 157 1 1
GPX4 CYP2B6 0 0 0 157 1 1
GPX4 GDPD3 0 0 0 229 1 1
GPX4 MIER2 0 0 162 161 1 1
GPX4 POLR2E 0 0 181 291 1 1
GPX4 SURF1 0 0 122 188 1 1
GPX4 DIABLO 0 0 241 257 1 2
GPX4 NDUFS5 0 0 57 214 1 1
GPX4 CYP3A5 0 0 0 150 1 1
GPX4 NDUFS7 0 0 169 273 1 1
GPX4 EMC2 0 0 147 183 1 1
GPX4 LPO 0 0 224 230 1 1
GPX4 OTUB1 270 0 0 285 1 1
GPX4 TUFM 0 0 43 169 1 2
GPX4 CYP3A4 0 0 0 150 1 1
GPX4 FECH 0 0 108 157 1 1
GPX4 MAF 0 0 124 196 1 1
GPX4 SLC3A2 0 0 387 430 1 1
GPX4 GDPD4 0 0 0 157 1 1
GPX4 BCHE 0 0 42 416 1 1
GPX4 NCF4 0 0 134 222 1 1
GPX4 IDH1 0 0 176 246 1 1
GPX4 SELV 0 0 651 705 1 1
GPX4 UBXN1 0 0 67 274 1 1
GPX4 FNDC5 0 0 74 181 1 1
GPX4 CBR3 0 0 142 180 1 1
GPX4 TMEM126A 0 0 0 183 1 1
GPX4 SIRT6 0 0 162 192 1 2
GPX4 CP 0 0 171 333 1 1
GPX4 NDUFA4 0 0 141 179 1 1
GPX4 CTH 0 0 138 294 1 1
GPX4 AMD1 0 0 0 298 1 1
GPX4 TSTA3 0 0 0 352 1 1
GPX4 ALDH3A2 0 0 123 247 1 1
GPX4 MT1B 0 0 0 159 1 1
GPX4 PLA2G10 0 0 0 158 1 1
GPX4 DUT 272 0 57 288 1 1
GPX4 LGSN 0 0 0 155 1 1
GPX4 ERO1L 0 0 157 397 1 1
GPX4 BLVRB 0 0 143 187 1 1
GPX4 BPGM 0 0 0 163 1 1
GPX4 ANXA8 0 0 134 174 1 1
GPX4 MSRB2 0 0 316 445 1 1
GPX4 HKDC1 0 0 0 189 1 1
GPX4 SELM 0 0 607 674 1 1
GPX4 AGXT2 0 0 0 201 1 1
GPX4 SLC17A6 0 0 0 181 1 1
GPX4 IMPA2 272 0 0 272 1 1
GPX4 GPX5 0 0 710 328 1 1
GPX4 CASP7 0 0 134 311 1 1
GPX4 MTIF2 0 0 0 150 1 1
GPX4 PVALB 0 0 161 190 1 1
GPX4 NAA38 0 0 0 172 1 1
GPX4 DNAJC18 0 0 108 188 1 1
GPX4 UCHL3 312 0 0 337 1 1
GPX4 SDHA 0 0 150 199 1 1
GPX4 CCL2 0 0 166 187 1 2
GPX4 ALB 0 0 283 603 1 2
GPX4 CASP8 0 0 268 313 1 2
GPX4 TXNDC16 0 0 0 200 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004602 Molecular Function glutathione peroxidase activity enables IBA
GO:0004602 Molecular Function glutathione peroxidase activity enables IDA
GO:0004602 Molecular Function glutathione peroxidase activity enables IMP
GO:0042802 Molecular Function identical protein binding enables IMP
GO:0047066 Molecular Function phospholipid-hydroperoxide glutathione peroxidase activity enables IBA
GO:0047066 Molecular Function phospholipid-hydroperoxide glutathione peroxidase activity enables IDA
GO:0047066 Molecular Function phospholipid-hydroperoxide glutathione peroxidase activity enables ISS
GO:0047066 Molecular Function phospholipid-hydroperoxide glutathione peroxidase activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0008430 Molecular Function selenium binding enables IEA
GO:0019369 Biological Process arachidonic acid metabolic process involved_in IDA
GO:0098869 Biological Process cellular oxidant detoxification involved_in IEA
GO:0006325 Biological Process chromatin organization involved_in IEA
GO:0006749 Biological Process glutathione metabolic process involved_in IEA
GO:0019372 Biological Process lipoxygenase pathway involved_in IDA
GO:0042759 Biological Process long-chain fatty acid biosynthetic process involved_in TAS
GO:0110076 Biological Process negative regulation of ferroptosis involved_in ISS
GO:0006644 Biological Process phospholipid metabolic process involved_in TAS
GO:0051258 Biological Process protein polymerization involved_in IMP
GO:0032355 Biological Process response to estradiol involved_in IEA
GO:0006979 Biological Process response to oxidative stress involved_in ISS
GO:0007283 Biological Process spermatogenesis involved_in ISS
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0070062 Cellular Component extracellular exosome located_in HDA
GO:0005739 Cellular Component mitochondrion is_active_in IBA
GO:0005635 Cellular Component nuclear envelope located_in IEA
GO:0005634 Cellular Component nucleus located_in HDA
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0032991 Cellular Component protein-containing complex part_of IMP
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
Synthesis of 5-eicosatetraenoic acids Reactome R-HSA-2142688
Synthesis of 12-eicosatetraenoic acid derivatives Reactome R-HSA-2142712
Arachidonic acid metabolism Reactome R-HSA-2142753
Synthesis of 15-eicosatetraenoic acid derivatives Reactome R-HSA-2142770
Metabolism of lipids Reactome R-HSA-556833
Fatty acid metabolism Reactome R-HSA-8978868
Biosynthesis of D-series resolvins Reactome R-HSA-9018676
Biosynthesis of DHA-derived SPMs Reactome R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) Reactome R-HSA-9018678
Biosynthesis of EPA-derived SPMs Reactome R-HSA-9018679
Biosynthesis of E-series 18(S)-resolvins Reactome R-HSA-9018896
Biosynthesis of aspirin-triggered D-series resolvins Reactome R-HSA-9020265
Biosynthesis of E-series 18(R)-resolvins Reactome R-HSA-9023661
Trans-sulfuration, one-carbon metabolism and related pathways (WP2525) WikiPathways WP2525_r123451
Selenium micronutrient network (WP15) WikiPathways WP15_r123380
Metapathway biotransformation Phase I and II (WP702) WikiPathways WP702_r106643
Ferroptosis (WP4313) WikiPathways WP4313_r123507
Folate metabolism (WP176) WikiPathways WP176_r121696
Glutathione metabolism (WP100) WikiPathways WP100_r107114
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001039847 3 mRNA transcript variant 2 NC_000019 Reference
NM_002085 5 mRNA transcript variant 1 NC_000019 Reference
NM_001367832 1 mRNA transcript variant 4 NC_000019 Reference
NM_001039848 4 mRNA transcript variant 3 NC_000019 Reference