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PYCARD

PYD and CARD domain containing
General Information
Name PYD and CARD domain containing
Alias
  • apoptosis-associated speck-like protein containing a CARD
  • caspase recruitment domain-containing protein 5
  • target of methylation-induced silencing 1
Gene_family Caspase recruitment domain containing|Pyrin domain containing
organism Homo sapiens
entrez_id 29108
location 16p11.2
transcript_count 2
exon_count 3
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Stringdb Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspa [...]
    nextProt Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response, acts as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:25847972). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, NLRP6, AIM2 and probably IFI16 (PubMed:15030775, PubMed:17349957, PubMed:19158676, PubMed:19158675, PubMed:30674671, PubMed:34678144). In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in RIGI-triggered pro-inflammatory responses and inflammasome activation. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
PYCARD BioGRID IFI16 GeneID BioGRID Affinity Capture-Western; Co-localization
PYCARD BioGRID CASP1 GeneID BioGRID Affinity Capture-Western; Co-localization
PYCARD BioGRID NLRP3 GeneID BioGRID Affinity Capture-Western; Co-localization
PYCARD BioGRID MARK4 GeneID BioGRID Co-localization
PYCARD BioGRID NLRP6 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID ESR2 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID PYCARD GeneID BioGRID Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid
PYCARD BioGRID USP3 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PYCARD BioGRID MAP3K7 GeneID BioGRID Co-fractionation
PYCARD BioGRID IFIT5 GeneID BioGRID Co-fractionation
PYCARD BioGRID ERC1 GeneID BioGRID Co-fractionation
PYCARD BioGRID TRAF3 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID CASP8 GeneID BioGRID Affinity Capture-Western; Co-localization
PYCARD BioGRID Nlrp3 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID ZFP91 GeneID BioGRID Affinity Capture-Western; Co-localization
PYCARD BioGRID PELI1 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID ANAPC10 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID TRIM28 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID GOT1 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID CCR1 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID BIRC5 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID NFATC2IP GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID C18orf21 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID ZYG11B GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID OR2A4 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID CDK15 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID STX17 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID PIGT GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID PIGP GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID NDUFA13 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID FCF1 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID SSUH2 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID SSBP2 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID AGPAT1 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID CUL2 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID CCL21 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID KLK10 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID PPP2R2B GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID HIF1A GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID ORF3a GeneID BioGRID Affinity Capture-Western; Co-localization
PYCARD BioGRID TRAF6 GeneID BioGRID Co-localization
PYCARD BioGRID ARIH2 GeneID BioGRID Co-localization; Co-purification
PYCARD BioGRID USP50 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
PYCARD BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID PAK1 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID TPM4 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID TMPRSS15 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID PML GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PYCARD BioGRID MYO1C GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID MCM4 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID LIG3 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID IL6ST GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID BMPR2 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID TSHZ2 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID DRC7 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID ARMC2 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID NAA15 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID FAM184A GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID NUP107 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID FSTL5 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID DNAJC28 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID LEMD3 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID CEP131 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID PSTPIP1 GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID INPP4B GeneID BioGRID Affinity Capture-MS
PYCARD BioGRID EXOC5 GeneID BioGRID Two-hybrid
PYCARD BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID RALB GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID IKBKB GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID CHUK GeneID BioGRID Affinity Capture-Western
PYCARD BioGRID NLRP2 GeneID BioGRID Affinity Capture-Western
PYCARD Protein PYDC2 GeneID HPRD
PYCARD Protein NLRP12 GeneID HPRD
PYCARD Protein NLRP1 GeneID HPRD
PYCARD Protein NLRC4 GeneID HPRD
PYCARD Protein NLRP3 GeneID HPRD
PYCARD Protein POP1 GeneID HPRD
PYCARD Protein SRF GeneID HPRD
PYCARD Protein MEFV GeneID HPRD
PYCARD Protein PRKAR1A GeneID HPRD
PYCARD Protein CASP1 GeneID HPRD
PYCARD BioGRID NLRC4 GeneID BioGRID Two-hybrid
PYCARD BioGRID MEFV GeneID BioGRID Affinity Capture-Western; Two-hybrid
PYCARD BioGRID PRKAR1A GeneID BioGRID Two-hybrid
PYCARD None None None BIND PYPAF1 interacts with ASC.
StringDB
A B experiments database textmining combined score hadb nhadb
PYCARD IL1RAP 0 0 194 194 1 1
PYCARD BAX 270 0 128 364 1 2
PYCARD SLC38A2 0 0 0 189 1 1
PYCARD NLRP11 0 0 433 433 1 1
PYCARD TLR5 0 0 335 349 1 1
PYCARD CHUK 270 540 260 739 1 1
PYCARD PTPN12 0 0 357 378 1 1
PYCARD CDKN2A 0 0 247 246 1 2
PYCARD CASP4 0 540 456 841 1 2
PYCARD ADCK1 0 0 95 190 1 1
PYCARD ITGAX 0 0 241 277 1 1
PYCARD UNC93B1 0 0 140 261 1 1
PYCARD ICAM1 0 0 166 192 1 2
PYCARD RALB 160 0 66 280 1 2
PYCARD LTBR 0 0 122 176 1 1
PYCARD USP31 0 0 150 174 1 1
PYCARD RIPK1 270 0 294 471 1 2
PYCARD CSF1 0 0 230 229 1 1
PYCARD CIITA 0 0 370 383 1 1
PYCARD TSPO 0 0 120 206 1 1
PYCARD NOD2 0 0 602 636 1 2
PYCARD PTPRC 0 0 203 273 1 1
PYCARD NLRP9 0 900 294 929 1 1
PYCARD HCK 0 0 75 260 1 1
PYCARD INPP4B 270 0 0 270 1 1
PYCARD MLKL 0 0 321 354 1 2
PYCARD BCL10 270 0 381 528 1 1
PYCARD ATG16L1 0 0 261 261 1 2
PYCARD CEP131 270 0 0 270 1 1
PYCARD TNFRSF21 0 0 161 189 1 1
PYCARD PSEN1 0 0 134 168 1 2
PYCARD TP73 0 0 294 326 1 2
PYCARD PANX2 0 0 82 256 1 1
PYCARD CRP 0 0 153 183 1 2
PYCARD CASP3 0 0 340 437 1 2
PYCARD PSMB9 0 0 134 233 1 1
PYCARD PTGS2 0 0 232 231 1 2
PYCARD LRRC3 0 0 415 422 1 1
PYCARD CXCL1 0 0 240 274 1 2
PYCARD CTSZ 0 0 124 181 1 1
PYCARD IL33 0 0 420 420 1 2
PYCARD CARD16 0 0 545 860 1 1
PYCARD FXYD3 0 0 152 505 1 1
PYCARD CD53 0 0 95 157 1 1
PYCARD REL 0 0 158 157 1 2
PYCARD NLRP3 870 900 989 999 1 2
PYCARD HSP90AA1 0 0 171 171 1 2
PYCARD CYBB 0 0 220 279 1 2
PYCARD CD28 0 0 107 181 1 1
PYCARD UTP15 0 0 0 250 1 1
PYCARD NAA15 270 0 0 270 1 1
PYCARD SQSTM1 270 0 304 470 1 2
PYCARD FCGR2B 0 0 150 192 1 1
PYCARD B2M 0 0 181 256 1 1
PYCARD MMP9 0 0 141 174 1 2
PYCARD MAPK3 0 0 328 328 1 2
PYCARD OMA1 0 0 0 161 1 1
PYCARD TREML2 0 0 48 187 1 1
PYCARD GBP7 0 0 95 160 1 1
PYCARD THEMIS2 0 0 0 154 1 1
PYCARD NOLC1 0 0 60 155 1 1
PYCARD ARHGDIA 0 0 0 167 1 1
PYCARD CD40 0 0 193 236 1 2
PYCARD NLRX1 0 0 451 452 1 2
PYCARD CTSS 0 0 108 297 1 1
PYCARD TNFRSF10B 0 0 156 199 1 2
PYCARD IL13 0 0 174 173 1 2
PYCARD INS 0 0 213 213 1 2
PYCARD ACTB 0 0 325 347 1 2
PYCARD SLC1A1 0 0 0 190 1 1
PYCARD TMPRSS15 270 0 0 270 1 1
PYCARD HIC1 0 0 245 244 1 1
PYCARD NPIPB15 0 0 244 243 1 1
PYCARD PEA15 0 0 46 169 1 1
PYCARD SRF 213 0 0 213 1 1
PYCARD AIF1 0 0 250 314 1 2
PYCARD ANKRD45 0 0 53 157 1 1
PYCARD GBP4 0 0 120 187 1 1
PYCARD TNFSF10 0 0 218 268 1 2
PYCARD CDKN2B 0 0 133 187 1 1
PYCARD TLR2 0 0 467 504 1 2
PYCARD VRK2 0 0 0 250 1 1
PYCARD MLH1 0 0 134 153 1 1
PYCARD TRAF3 0 0 272 384 1 2
PYCARD BECN1 270 0 227 472 1 2
PYCARD NUP107 270 0 0 270 1 1
PYCARD THBS1 0 0 174 173 1 1
PYCARD CD74 0 0 61 178 1 1
PYCARD TLR6 0 0 267 283 1 1
PYCARD CASP1 973 900 989 999 1 2
PYCARD POP1 213 0 0 213 1 1
PYCARD JUN 0 0 235 235 1 2
PYCARD NOD1 0 0 597 635 1 2
PYCARD CA6 0 0 43 156 1 1
PYCARD TMEM173 0 0 212 231 1 1
PYCARD CARD11 0 0 183 263 1 1
PYCARD DAPK1 0 0 386 430 1 2
PYCARD GZMA 0 0 81 208 1 1
PYCARD IL10RA 0 0 157 236 1 1
PYCARD IL18R1 0 0 170 207 1 1
PYCARD BCL2L11 0 0 154 153 1 2
PYCARD CD86 0 0 145 213 1 1
PYCARD ENSG00000173366 0 0 393 397 1 1
PYCARD NLRP13 0 0 456 456 1 1
PYCARD CAPG 0 0 0 269 1 1
PYCARD RARRES1 0 0 213 213 1 1
PYCARD S1PR4 0 0 0 150 1 1
PYCARD DLEC1 0 0 150 188 1 1
PYCARD LTA 0 0 89 185 1 1
PYCARD FAM184A 270 0 0 270 1 1
PYCARD P2RY12 0 0 113 186 1 1
PYCARD IL36RN 0 0 101 157 1 1
PYCARD CCR5 0 0 141 192 1 1
PYCARD GALR2 0 0 94 189 1 1
PYCARD IL37 0 0 163 169 1 1
PYCARD IRAK3 0 0 136 263 1 1
PYCARD MYO1C 270 0 0 297 1 1
PYCARD NLRP8 0 0 165 177 1 1
PYCARD GRN 0 0 0 215 1 1
PYCARD FASLG 0 0 214 214 1 1
PYCARD S100A8 0 0 74 182 1 2
PYCARD NFKBIE 0 0 66 185 1 1
PYCARD TICAM1 0 0 260 277 1 2
PYCARD SOCS3 0 0 170 169 1 1
PYCARD CLEC6A 0 0 233 249 1 1
PYCARD PRKAR1A 606 0 0 606 1 2
PYCARD IFNK 0 0 0 175 1 1
PYCARD IGSF6 0 0 0 151 1 1
PYCARD HIVEP3 0 0 0 305 1 1
PYCARD MNDA 0 0 302 369 1 1
PYCARD RIPK2 0 0 502 560 1 2
PYCARD SLC7A10 0 0 0 198 1 1
PYCARD OSTF1 0 0 112 184 1 1
PYCARD ITGB2 0 0 81 236 1 1
PYCARD TREM2 0 0 193 271 1 1
PYCARD IFNGR1 0 0 126 177 1 1
PYCARD RUNX3 0 0 123 171 1 1
PYCARD ZFP91 270 0 75 311 1 1
PYCARD ARMC2 270 0 0 285 1 1
PYCARD CASP14 0 0 276 398 1 1
PYCARD EIF2AK2 0 0 107 262 1 2
PYCARD ZFP82 0 0 160 159 1 1
PYCARD PSMB8 0 0 306 409 1 1
PYCARD CALR 0 0 120 229 1 1
PYCARD USP50 270 0 44 272 1 1
PYCARD CD8A 0 0 270 270 1 1
PYCARD HLX 0 0 0 183 1 1
PYCARD PKN1 0 0 167 167 1 1
PYCARD API5 0 0 108 263 1 1
PYCARD ULK1 0 0 108 203 1 2
PYCARD CCR7 0 0 96 153 1 1
PYCARD IKBKG 270 720 261 835 1 1
PYCARD PDRG1 0 0 66 206 1 1
PYCARD MUSK 0 0 0 192 1 1
PYCARD C3 0 0 157 156 1 2
PYCARD DEFB110 0 0 173 173 1 1
PYCARD MAPK8 0 0 150 180 1 2
PYCARD DEDD2 0 0 0 290 1 1
PYCARD CXCR5 0 0 0 233 1 1
PYCARD C3orf67 0 0 0 209 1 1
PYCARD P2RX7 0 0 460 498 1 2
PYCARD RRBP1 0 0 96 161 1 1
PYCARD GBP3 0 0 90 173 1 1
PYCARD CCR1 0 0 124 186 1 1
PYCARD DAPK3 0 0 0 362 1 2
PYCARD IL2RG 0 0 73 257 1 1
PYCARD VAV1 0 0 66 151 1 1
PYCARD NCF2 0 0 90 203 1 1
PYCARD CASP16 0 0 66 186 1 1
PYCARD DFFB 0 0 124 178 1 1
PYCARD MAP1LC3B 0 0 150 165 1 2
PYCARD C4orf48 0 0 158 180 1 1
PYCARD ARHGDIB 0 0 66 497 1 1
PYCARD IL1F10 0 0 96 152 1 1
PYCARD MYO1F 0 0 0 175 1 1
PYCARD ISG15 0 0 123 188 1 2
PYCARD DIABLO 0 0 181 182 1 2
PYCARD SUGT1 0 650 108 674 1 1
PYCARD IFIH1 0 0 387 410 1 1
PYCARD NFKBIB 0 0 93 187 1 1
PYCARD CCR2 0 0 210 266 1 2
PYCARD MVK 0 0 166 165 1 1
PYCARD NLRP14 0 0 249 410 1 1
PYCARD LAPTM5 0 0 58 222 1 1
PYCARD ATG5 0 0 195 195 1 2
PYCARD CXCL9 0 0 134 181 1 1
PYCARD BCL2L14 0 0 95 174 1 1
PYCARD TLR8 0 0 306 332 1 1
PYCARD IGSF9 0 0 0 181 1 1
PYCARD CXCR3 0 0 88 174 1 1
PYCARD IRF2 0 0 116 151 1 1
PYCARD WDR90 0 0 108 586 1 1
PYCARD IRF1 0 0 258 307 1 2
PYCARD C1QA 0 0 81 152 1 1
PYCARD PYDC1 270 800 390 850 1 1
PYCARD SASH3 0 0 0 192 1 1
PYCARD CX3CR1 0 0 161 161 1 1
PYCARD DICER1 0 0 66 203 1 1
PYCARD SPI1 0 0 175 324 1 1
PYCARD IL17A 0 0 260 260 1 2
PYCARD CTSB 0 0 425 429 1 2
PYCARD NLRP5 0 0 172 215 1 1
PYCARD MCL1 0 0 156 189 1 2
PYCARD RNH1 0 0 432 432 1 1
PYCARD TRAF6 273 0 325 500 1 2
PYCARD SLC5A8 0 0 95 151 1 1
PYCARD POU2AF1 0 0 323 323 1 1
PYCARD P2RY2 0 0 124 171 1 1
PYCARD ITGAM 0 0 281 357 1 1
PYCARD ARHGDIG 0 0 71 453 1 1
PYCARD SLC1A2 0 0 0 186 1 1
PYCARD PYHIN1 0 0 261 289 1 1
PYCARD IL18BP 0 0 235 251 1 1
PYCARD CASP9 0 0 389 467 1 2
PYCARD ESR1 0 0 171 171 1 2
PYCARD DHX36 0 0 204 204 1 1
PYCARD TLR7 0 0 359 373 1 2
PYCARD PIM2 0 0 0 161 1 1
PYCARD IRF5 0 0 195 318 1 1
PYCARD HMGB1 0 0 406 416 1 2
PYCARD IFNB1 0 0 421 578 1 1
PYCARD LYN 0 0 123 221 1 1
PYCARD CYCS 0 0 241 240 1 2
PYCARD DFNA5 0 0 263 263 1 1
PYCARD WT1 0 0 182 181 1 1
PYCARD RARB 0 0 322 321 1 1
PYCARD PDLIM4 0 0 99 155 1 1
PYCARD BIRC3 0 0 260 313 1 1
PYCARD FERMT3 0 0 0 174 1 1
PYCARD LEP 0 0 145 164 1 1
PYCARD RHOT2 0 0 73 152 1 1
PYCARD SYK 270 0 507 700 1 2
PYCARD TNFRSF10A 0 0 147 240 1 1
PYCARD GOLGA4 0 0 326 325 1 1
PYCARD NFKBIA 0 0 302 330 1 2
PYCARD CCNA1 0 0 140 161 1 1
PYCARD TIMP3 0 0 181 181 1 1
PYCARD LIG3 270 0 0 270 1 1
PYCARD CLEC4E 0 0 231 248 1 1
PYCARD GNB4 0 0 49 150 1 1
PYCARD FCGR2A 0 0 94 153 1 1
PYCARD IL4 0 0 218 218 1 1
PYCARD CORO1B 0 0 112 157 1 1
PYCARD CHFR 0 0 166 165 1 1
PYCARD PLEKHO1 0 0 0 190 1 1
PYCARD NLRP6 0 800 811 962 1 1
PYCARD FPR1 0 0 291 290 1 1
PYCARD HS3ST3B1 0 0 75 160 1 1
PYCARD LRR1 0 0 201 201 1 1
PYCARD CASP7 0 0 305 394 1 1
PYCARD IL20 0 0 0 186 1 1
PYCARD NEK7 0 0 377 377 1 1
PYCARD TYROBP 0 0 120 407 1 1
PYCARD FCER1G 0 0 112 273 1 1
PYCARD ARPC1B 0 0 81 193 1 1
PYCARD CARD17 0 0 285 766 1 1
PYCARD SLC7A7 0 0 0 175 1 1
PYCARD MCM4 270 0 0 270 1 1
PYCARD CASP5 0 900 939 996 1 1
PYCARD PPFIBP2 0 0 61 163 1 1
PYCARD OTULIN 0 0 106 304 1 1
PYCARD LRRFIP1 0 0 203 203 1 1
PYCARD CCL2 0 0 342 342 1 2
PYCARD ALB 0 0 203 223 1 2
PYCARD CD68 0 0 218 266 1 2
PYCARD CASP8 675 800 667 979 1 2
PYCARD CCL4 0 0 170 211 1 1
PYCARD GBP1 0 0 91 177 1 1
PYCARD IL1A 0 0 469 469 1 1
PYCARD MAVS 0 0 460 539 1 2
PYCARD TRAT1 0 0 187 187 1 1
PYCARD ACTG1 0 0 166 171 1 1
PYCARD IAPP 0 0 274 274 1 2
PYCARD PAX6 0 0 157 156 1 1
PYCARD TRADD 0 0 268 321 1 1
PYCARD IL10 0 0 342 342 1 2
PYCARD PSMB10 0 0 53 169 1 1
PYCARD GFAP 0 0 126 155 1 2
PYCARD IRAK4 0 0 242 254 1 1
PYCARD CXCL2 0 0 167 185 1 1
PYCARD TAP2 0 0 0 162 1 1
PYCARD ADAP1 0 0 0 189 1 1
PYCARD TNFRSF10C 0 0 106 172 1 1
PYCARD NCF4 0 0 87 242 1 1
PYCARD BCL2L10 0 0 171 250 1 1
PYCARD PTPN20A 0 0 108 192 1 1
PYCARD TPM4 270 0 0 270 1 1
PYCARD MB21D1 0 0 358 384 1 1
PYCARD SFRP1 0 0 166 165 1 1
PYCARD ICAM3 0 0 97 187 1 1
PYCARD PYDC2 462 800 294 917 1 1
PYCARD DIRAS2 0 0 0 155 1 1
PYCARD AIM2 870 900 988 999 1 2
PYCARD DDX58 270 0 509 626 1 1
PYCARD DDX41 0 0 264 264 1 1
PYCARD CCL3 0 0 218 257 1 1
PYCARD FCGR3B 0 0 95 215 1 1
PYCARD MAP3K7 0 0 182 231 1 2
PYCARD NLRP4 0 800 415 878 1 1
PYCARD TRIM40 0 720 0 720 1 1
PYCARD ZBP1 0 0 249 563 1 1
PYCARD CRADD 0 0 325 325 1 1
PYCARD BLNK 0 0 45 188 1 1
PYCARD NCF1 0 0 171 268 1 1
PYCARD P2RX4 0 0 193 193 1 1
PYCARD IRAK1 0 0 298 309 1 1
PYCARD SFXN1 0 0 66 206 1 1
PYCARD RAF1 0 0 0 202 1 2
PYCARD CARD9 270 0 421 651 1 1
PYCARD TNFRSF10D 0 0 140 272 1 1
PYCARD TRAF1 0 0 156 211 1 1
PYCARD CAMP 0 0 138 167 1 2
PYCARD NLRP2 270 0 720 825 1 1
PYCARD FADD 0 0 341 355 1 2
PYCARD ESX1 0 0 174 173 1 1
PYCARD LRRC25 0 0 96 218 1 1
PYCARD LAMP1 160 0 134 258 1 2
PYCARD TSHZ2 270 0 0 270 1 1
PYCARD CFLAR 0 0 229 359 1 2
PYCARD HIVEP1 0 0 0 220 1 1
PYCARD PSTPIP1 270 650 355 829 1 1
PYCARD SLC7A8 0 0 0 198 1 1
PYCARD MYD88 0 0 506 543 1 2
PYCARD FCGR1A 0 0 113 223 1 1
PYCARD LCN2 0 0 112 150 1 1
PYCARD TP53 0 0 283 282 1 2
PYCARD GAL3ST4 0 0 142 274 1 1
PYCARD TRIM16 0 0 48 353 1 2
PYCARD FDXR 0 0 0 210 1 1
PYCARD IRF9 0 0 163 163 1 1
PYCARD PROK2 0 0 71 157 1 1
PYCARD TOM1L2 0 0 66 173 1 1
PYCARD ERC1 0 720 0 720 1 1
PYCARD BNIP2 0 0 225 247 1 1
PYCARD CSRNP3 0 0 113 500 1 1
PYCARD PTPN22 0 0 123 183 1 1
PYCARD STAT3 0 0 218 218 1 2
PYCARD S100A10 0 0 0 221 1 1
PYCARD HRK 0 0 150 203 1 1
PYCARD TXN 0 0 231 230 1 1
PYCARD BMPR2 270 0 0 282 1 1
PYCARD ERN1 0 0 181 194 1 2
PYCARD AATF 0 0 140 238 1 1
PYCARD SIVA1 0 0 108 257 1 1
PYCARD MTRF1L 0 0 70 176 1 1
PYCARD CTLA4 0 0 124 159 1 2
PYCARD CYBA 0 0 166 281 1 1
PYCARD LY86 0 0 94 345 1 1
PYCARD SCGB3A1 0 0 213 213 1 1
PYCARD PRKCDBP 0 0 134 153 1 1
PYCARD DFFA 0 0 160 159 1 1
PYCARD CARD18 0 0 397 474 1 1
PYCARD BAK1 0 0 202 247 1 2
PYCARD NLRC5 0 0 504 524 1 1
PYCARD DIRAS1 0 0 0 155 1 1
PYCARD PAK1 270 0 0 270 1 2
PYCARD APAF1 0 0 389 388 1 2
PYCARD RNASEL 0 0 164 177 1 1
PYCARD HPRT1 0 0 152 152 1 1
PYCARD IL27RA 0 0 57 217 1 1
PYCARD FSTL5 270 0 0 270 1 1
PYCARD ARIH2 270 0 71 292 1 1
PYCARD CD209 0 0 155 170 1 1
PYCARD MS4A6A 0 0 61 158 1 1
PYCARD IFI30 0 0 83 293 1 1
PYCARD NAIP 0 540 601 810 1 1
PYCARD DENND1C 0 0 83 152 1 1
PYCARD MEFV 865 800 942 981 1 1
PYCARD TAB1 0 0 159 164 1 1
PYCARD DDX3X 0 720 90 735 1 1
PYCARD RNF135 0 0 125 157 1 1
PYCARD DHX33 0 900 218 919 1 1
PYCARD TAB2 0 0 181 181 1 2
PYCARD TIRAP 0 0 324 323 1 1
PYCARD GPSM3 0 0 0 172 1 1
PYCARD TNF 0 0 468 520 1 2
PYCARD TANK 0 0 160 159 1 2
PYCARD FCGR1B 0 0 0 156 1 1
PYCARD IL1R1 0 0 464 463 1 1
PYCARD CASP2 0 0 397 474 1 1
PYCARD IL1RN 0 0 397 445 1 1
PYCARD IRGM 0 0 181 181 1 2
PYCARD SMAP2 0 0 0 156 1 1
PYCARD SLC1A5 0 0 0 174 1 1
PYCARD IFNA1 0 0 282 282 1 1
PYCARD TMEFF2 0 0 134 153 1 1
PYCARD CD44 0 0 150 171 1 2
PYCARD IL18 0 800 759 956 1 2
PYCARD BRCA1 270 0 150 377 1 2
PYCARD NLRP12 213 800 606 932 1 1
PYCARD GBP5 0 0 201 238 1 1
PYCARD SMAP1 0 0 0 156 1 1
PYCARD ATF3 0 0 129 161 1 2
PYCARD DHX58 0 0 278 305 1 1
PYCARD GADD45A 0 0 183 199 1 1
PYCARD CARD10 0 0 193 274 1 1
PYCARD TLR1 0 0 321 355 1 1
PYCARD NFE2L2 0 0 166 165 1 2
PYCARD NLRP10 0 0 536 536 1 1
PYCARD SOCS1 0 0 144 175 1 1
PYCARD FHIT 0 0 141 228 1 1
PYCARD BTK 0 0 112 178 1 1
PYCARD MARCH7 0 0 195 195 1 1
PYCARD IRF7 0 0 294 345 1 1
PYCARD CSF1R 0 0 93 150 1 1
PYCARD GSTP1 0 0 273 273 1 1
PYCARD CASP10 0 0 166 273 1 1
PYCARD MPEG1 0 0 95 160 1 1
PYCARD TNFAIP3 0 0 183 203 1 2
PYCARD IL1R2 0 0 150 176 1 1
PYCARD IFNAR1 0 0 218 229 1 1
PYCARD CCND2 0 0 134 154 1 1
PYCARD IFI16 486 0 629 814 1 1
PYCARD BCL2A1 0 0 202 285 1 1
PYCARD NOL3 0 0 325 392 1 1
PYCARD TXNIP 0 0 420 445 1 2
PYCARD SLC12A9 0 0 0 183 1 1
PYCARD MEGF11 0 0 81 181 1 1
PYCARD CIDEB 0 0 142 189 1 1
PYCARD NCKAP1L 0 0 0 151 1 1
PYCARD RELB 0 0 143 174 1 2
PYCARD S100A9 0 0 82 173 1 1
PYCARD LEMD3 270 0 0 270 1 1
PYCARD GSDMA 0 0 369 383 1 1
PYCARD TLR9 0 0 400 416 1 2
PYCARD CLEC4D 0 0 156 214 1 1
PYCARD CARD6 0 0 390 467 1 1
PYCARD TNFSF8 0 0 151 176 1 1
PYCARD KCNAB3 0 0 63 271 1 1
PYCARD IL6ST 270 0 0 270 1 1
PYCARD NLRP7 0 0 561 641 1 1
PYCARD ANXA5 0 0 160 159 1 2
PYCARD NME5 0 0 71 266 1 1
PYCARD LGALS9 0 0 60 237 1 1
PYCARD MGMT 0 0 294 294 1 2
PYCARD IRF3 0 0 391 404 1 2
PYCARD BIRC2 0 0 266 318 1 1
PYCARD IFNG 0 0 171 275 1 2
PYCARD SPTA1 0 0 43 211 1 1
PYCARD DHX9 0 0 142 195 1 1
PYCARD BIRC5 257 0 48 339 1 2
PYCARD GPRC5A 0 0 123 362 1 1
PYCARD HIBCH 0 0 60 167 1 1
PYCARD PLCG2 0 0 57 173 1 1
PYCARD CCL5 0 0 241 276 1 2
PYCARD GSDMD 0 720 662 915 1 2
PYCARD BIRC8 0 0 150 222 1 1
PYCARD MALT1 270 600 210 768 1 1
PYCARD CXCL10 0 0 212 237 1 2
PYCARD KCNJ11 0 0 257 256 1 1
PYCARD PANX3 0 0 74 250 1 1
PYCARD KATNB1 0 0 0 250 1 1
PYCARD LGALS9B 0 0 0 181 1 1
PYCARD HSP90AB1 0 650 86 669 1 2
PYCARD NLRC4 500 800 840 989 1 2
PYCARD IKBKB 270 540 245 733 1 2
PYCARD PANX1 0 0 426 519 1 1
PYCARD CDK8 0 0 48 150 1 1
PYCARD TLR4 0 0 518 531 1 2
PYCARD XIAP 0 0 263 326 1 2
PYCARD EMR1 0 0 108 189 1 1
PYCARD PML 270 0 42 270 1 2
PYCARD TNFRSF25 0 0 119 160 1 1
PYCARD GAPDH 0 0 325 328 1 2
PYCARD SLC25A3 0 0 0 215 1 1
PYCARD CSF2 0 0 218 218 1 1
PYCARD LY96 0 0 212 254 1 1
PYCARD NFKB1 0 0 236 280 1 2
PYCARD HMGB2 0 0 46 212 1 1
PYCARD GBP2 0 0 134 225 1 1
PYCARD RELA 0 0 183 183 1 2
PYCARD CDH13 0 0 265 265 1 1
PYCARD AKT1 0 0 194 207 1 2
PYCARD BCL2L1 0 0 209 226 1 2
PYCARD SPRYD4 0 0 147 241 1 1
PYCARD PPARG 0 0 153 152 1 2
PYCARD CD4 0 0 294 334 1 2
PYCARD PIGP 257 0 0 256 1 1
PYCARD INPP5D 0 0 74 208 1 1
PYCARD IFIT3 0 0 134 164 1 1
PYCARD SEMA7A 0 0 0 384 1 1
PYCARD VCAM1 0 0 306 306 1 1
PYCARD TRIM25 0 0 160 307 1 1
PYCARD CLEC7A 0 0 378 391 1 1
PYCARD TLR10 0 0 130 181 1 1
PYCARD CARD8 0 900 724 974 1 1
PYCARD CARD14 0 0 162 351 1 1
PYCARD CASP6 0 0 270 364 1 1
PYCARD LGALS9C 0 0 0 191 1 1
PYCARD C3AR1 0 0 138 185 1 1
PYCARD TNFRSF1B 0 0 206 251 1 1
PYCARD BNIP3L 0 0 150 244 1 2
PYCARD C1QB 0 0 115 171 1 1
PYCARD IKBKE 0 0 180 436 1 1
PYCARD IGSF9B 0 0 0 211 1 1
PYCARD SAMSN1 0 0 56 207 1 1
PYCARD TEP1 0 0 134 171 1 1
PYCARD MAP1LC3A 0 0 120 175 1 2
PYCARD FCGR3A 0 0 94 211 1 1
PYCARD PRKCD 0 0 150 185 1 2
PYCARD PARP10 0 0 62 164 1 1
PYCARD IFIT1 0 0 150 172 1 1
PYCARD RIPK3 0 0 343 418 1 2
PYCARD TBK1 0 0 321 383 1 2
PYCARD CXCL8 0 0 321 321 1 2
PYCARD ADAP2 0 0 0 175 1 1
PYCARD SLC1A7 0 0 0 189 1 1
PYCARD HMOX1 0 0 142 180 1 2
PYCARD PTPN6 0 0 88 172 1 1
PYCARD RASSF1 0 0 368 381 1 1
PYCARD LRRC27 0 0 134 152 1 1
PYCARD TRAF5 0 0 135 154 1 1
PYCARD HCLS1 0 0 0 173 1 1
PYCARD CFAP20 0 0 0 209 1 1
PYCARD RAC2 0 0 90 317 1 1
PYCARD IL1B 0 900 802 980 1 2
PYCARD STAT1 0 0 256 256 1 2
PYCARD DNAJC28 270 0 0 270 1 1
PYCARD CCDC135 270 0 0 270 1 1
PYCARD BIRC6 0 0 150 186 1 1
PYCARD TLR3 0 0 392 392 1 2
PYCARD TNFRSF1A 0 0 310 325 1 1
PYCARD RSAD2 0 0 112 167 1 1
PYCARD CORO1A 0 0 129 253 1 1
PYCARD LGALS3 0 0 123 195 1 2
PYCARD NLRC3 270 0 576 692 1 1
PYCARD MPO 0 0 167 191 1 2
PYCARD EIF2AK3 0 0 122 229 1 2
PYCARD LYZ 0 0 128 182 1 1
PYCARD SCAF11 0 0 151 150 1 1
PYCARD IL6 0 0 465 474 1 2
PYCARD NLRP1 270 900 905 938 1 1
PYCARD APOE 0 0 180 179 1 2
PYCARD TRPV2 0 0 94 163 1 1
PYCARD PDCD5 0 0 177 177 1 1
PYCARD GATA5 0 0 263 263 1 1
PYCARD POTEF 0 0 167 194 1 1
PYCARD PIDD1 0 0 165 165 1 1
PYCARD NOC2L 0 0 56 155 1 1
PYCARD DOCK2 0 0 181 231 1 1
PYCARD DAP3 0 0 67 321 1 1
PYCARD XRCC2 0 0 0 216 1 1
PYCARD IRF8 0 0 155 218 1 1
PYCARD SAMD9L 0 0 96 161 1 1
PYCARD PTGS1 0 0 389 412 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0070700 Molecular Function BMP receptor binding enables IPI
GO:0032090 Molecular Function Pyrin domain binding enables IPI
GO:0008656 Molecular Function cysteine-type endopeptidase activator activity involved in apoptotic process enables NAS
GO:0019899 Molecular Function enzyme binding enables IPI
GO:0042802 Molecular Function identical protein binding enables IDA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0005138 Molecular Function interleukin-6 receptor binding enables IPI
GO:0017024 Molecular Function myosin I binding enables IPI
GO:0002020 Molecular Function protease binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0046983 Molecular Function protein dimerization activity enables IDA
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0044325 Molecular Function transmembrane transporter binding enables IEA
GO:0005523 Molecular Function tropomyosin binding enables IPI
GO:0044546 Biological Process NLRP3 inflammasome complex assembly involved_in IDA
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IBA
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in NAS
GO:0002218 Biological Process activation of innate immune response involved_in IDA
GO:0006915 Biological Process apoptotic process involved_in TAS
GO:0071347 Biological Process cellular response to interleukin-1 involved_in IDA
GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IDA
GO:0071356 Biological Process cellular response to tumor necrosis factor involved_in IDA
GO:0050829 Biological Process defense response to Gram-negative bacterium involved_in IMP
GO:0050830 Biological Process defense response to Gram-positive bacterium involved_in IEA
GO:0051607 Biological Process defense response to virus involved_in IDA
GO:0051607 Biological Process defense response to virus involved_in NAS
GO:0046456 Biological Process icosanoid biosynthetic process involved_in NAS
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0072332 Biological Process intrinsic apoptotic signaling pathway by p53 class mediator involved_in IMP
GO:0042771 Biological Process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator involved_in IMP
GO:0044351 Biological Process macropinocytosis involved_in ISS
GO:0001773 Biological Process myeloid dendritic cell activation involved_in IMP
GO:0002277 Biological Process myeloid dendritic cell activation involved in immune response involved_in ISS
GO:0032088 Biological Process negative regulation of NF-kappaB transcription factor activity involved_in IMP
GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in IDA
GO:1900016 Biological Process negative regulation of cytokine production involved in inflammatory response involved_in IMP
GO:0032688 Biological Process negative regulation of interferon-beta production involved_in IMP
GO:0071901 Biological Process negative regulation of protein serine/threonine kinase activity involved_in IDA
GO:0007231 Biological Process osmosensory signaling pathway involved_in NAS
GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in NAS
GO:0051091 Biological Process positive regulation of DNA-binding transcription factor activity involved_in IDA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IMP
GO:0046330 Biological Process positive regulation of JNK cascade involved_in IMP
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0050870 Biological Process positive regulation of T cell activation involved_in IMP
GO:2000406 Biological Process positive regulation of T cell migration involved_in ISS
GO:0030838 Biological Process positive regulation of actin filament polymerization involved_in ISS
GO:0042104 Biological Process positive regulation of activated T cell proliferation involved_in ISS
GO:0002821 Biological Process positive regulation of adaptive immune response involved_in IMP
GO:0002588 Biological Process positive regulation of antigen processing and presentation of peptide antigen via MHC class II involved_in ISS
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
GO:0032722 Biological Process positive regulation of chemokine production involved_in IMP
GO:2001056 Biological Process positive regulation of cysteine-type endopeptidase activity involved_in IDA
GO:0043280 Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IDA
GO:0043280 Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IMP
GO:0002230 Biological Process positive regulation of defense response to virus by host involved_in IEA
GO:2001238 Biological Process positive regulation of extrinsic apoptotic signaling pathway involved_in IDA
GO:0050729 Biological Process positive regulation of inflammatory response involved_in IDA
GO:0050729 Biological Process positive regulation of inflammatory response involved_in ISO
GO:0050729 Biological Process positive regulation of inflammatory response involved_in NAS
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IDA
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IMP
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in ISO
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in NAS
GO:0032733 Biological Process positive regulation of interleukin-10 production involved_in IMP
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in IMP
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in ISS
GO:0032757 Biological Process positive regulation of interleukin-8 production involved_in IMP
GO:0060907 Biological Process positive regulation of macrophage cytokine production involved_in IEA
GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IPI
GO:0050766 Biological Process positive regulation of phagocytosis involved_in ISS
GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in IDA
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IMP
GO:0032729 Biological Process positive regulation of type II interferon production involved_in ISS
GO:0051260 Biological Process protein homooligomerization involved_in IDA
GO:0070269 Biological Process pyroptosis involved_in NAS
GO:0010506 Biological Process regulation of autophagy involved_in IEA
GO:2001242 Biological Process regulation of intrinsic apoptotic signaling pathway involved_in IDA
GO:0031647 Biological Process regulation of protein stability involved_in ISS
GO:0010803 Biological Process regulation of tumor necrosis factor-mediated signaling pathway involved_in IMP
GO:0007165 Biological Process signal transduction involved_in NAS
GO:0033209 Biological Process tumor necrosis factor-mediated signaling pathway involved_in IDA
GO:0097169 Cellular Component AIM2 inflammasome complex part_of IDA
GO:0097169 Cellular Component AIM2 inflammasome complex part_of IPI
GO:0000139 Cellular Component Golgi membrane located_in IDA
GO:0008385 Cellular Component IkappaB kinase complex part_of IDA
GO:0008385 Cellular Component IkappaB kinase complex part_of TAS
GO:0072558 Cellular Component NLRP1 inflammasome complex part_of IDA
GO:0072558 Cellular Component NLRP1 inflammasome complex part_of IPI
GO:0072559 Cellular Component NLRP3 inflammasome complex part_of IDA
GO:0072559 Cellular Component NLRP3 inflammasome complex part_of IPI
GO:0140738 Cellular Component NLRP6 inflammasome complex part_of IDA
GO:0035578 Cellular Component azurophil granule lumen located_in TAS
GO:0061702 Cellular Component canonical inflammasome complex part_of IBA
GO:0061702 Cellular Component canonical inflammasome complex part_of IPI
GO:0061702 Cellular Component canonical inflammasome complex part_of NAS
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005737 Cellular Component cytoplasm located_in NAS
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005783 Cellular Component endoplasmic reticulum located_in IEA
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005874 Cellular Component microtubule located_in NAS
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0043025 Cellular Component neuronal cell body located_in IEA
GO:0005730 Cellular Component nucleolus located_in IDA
GO:0005730 Cellular Component nucleolus located_in NAS
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005634 Cellular Component nucleus located_in ISS
GO:0032991 Cellular Component protein-containing complex part_of IDA
GO:0034774 Cellular Component secretory granule lumen located_in TAS
Pathways
Name DB ID
Disease Reactome R-HSA-1643685
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
CLEC7A (Dectin-1) signaling Reactome R-HSA-5607764
C-type lectin receptors (CLRs) Reactome R-HSA-5621481
CLEC7A/inflammasome pathway Reactome R-HSA-5660668
Infectious disease Reactome R-HSA-5663205
Inflammasomes Reactome R-HSA-622312
Neutrophil degranulation Reactome R-HSA-6798695
The NLRP3 inflammasome Reactome R-HSA-844456
The AIM2 inflammasome Reactome R-HSA-844615
Leishmania infection Reactome R-HSA-9658195
Purinergic signaling in leishmaniasis infection Reactome R-HSA-9660826
Cell recruitment (pro-inflammatory response) Reactome R-HSA-9664424
SARS-CoV-1 Infection Reactome R-HSA-9678108
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-1-host interactions Reactome R-HSA-9692914
SARS-CoV-1 activates/modulates innate immune responses Reactome R-HSA-9692916
Parasitic Infection Pathways Reactome R-HSA-9824443
Viral Infection Pathways Reactome R-HSA-9824446
Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
TYROBP causal network in microglia (WP3945) WikiPathways WP3945_r116679
Acute viral myocarditis (WP4298) WikiPathways WP4298_r123508
Prostaglandin signaling (WP5088) WikiPathways WP5088_r119639
Nanomaterial-induced inflammasome activation (WP3890) WikiPathways WP3890_r124504
Activation of NLRP3 inflammasome by SARS-CoV-2 (WP4876) WikiPathways WP4876_r124661
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_145182 3 mRNA transcript variant 2 NC_000016 Reference
NM_013258 5 mRNA transcript variant 1 NC_000016 Reference