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GRP

gastrin releasing peptide
General Information
Name gastrin releasing peptide
Alias
  • gastrin-releasing peptide
  • bombesin
  • neuromedin C
  • pre-progastrin releasing peptide
  • prepro-GRP
  • testicular tissue protein Li 103
Gene_family Neuropeptides
organism Homo sapiens
entrez_id 2922
location 18q21.32
transcript_count 7
exon_count 5
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
    Stringdb Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Endogenous ligands
    nextProt Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
GRP BioGRID ALX1 GeneID BioGRID Two-hybrid
GRP BioGRID GRPR GeneID BioGRID Protein-peptide
GRP Protein MEP1B GeneID HPRD
GRP Protein MEP1A GeneID HPRD
GRP Protein GRPR GeneID HPRD
GRP Protein DPP4 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
GRP HCRT 0 500 423 699 1 1
GRP MLNR 0 0 113 355 1 1
GRP OPN4 0 0 273 288 1 1
GRP GNA15 0 0 286 286 1 1
GRP CRP 0 0 241 240 1 2
GRP CCKAR 0 0 526 536 1 1
GRP SSTR2 0 0 455 468 1 1
GRP PGLYRP1 0 0 134 190 1 1
GRP AFP 0 0 286 286 1 2
GRP PSEN1 0 0 103 199 1 2
GRP PTGS2 0 0 182 181 1 2
GRP XCL2 0 500 0 503 1 1
GRP CASP3 0 0 163 164 1 2
GRP ERBB3 0 0 181 181 1 1
GRP SLC5A11 0 0 113 346 1 1
GRP GLP1R 0 0 324 366 1 1
GRP ACE 0 0 207 207 1 1
GRP STUB1 0 0 276 276 1 2
GRP DPRX 0 0 163 163 1 1
GRP BCAR1 0 0 398 398 1 1
GRP SAGE1 0 0 170 169 1 1
GRP FPR2 0 0 182 181 1 1
GRP SELL 0 0 166 165 1 1
GRP REN 0 0 150 168 1 1
GRP INS 0 0 764 764 1 2
GRP ACTB 0 0 209 225 1 2
GRP PRLH 0 0 283 282 1 1
GRP CSNK1E 0 0 91 152 1 1
GRP NR2C2 0 0 218 219 1 1
GRP MMP9 0 0 193 193 1 2
GRP MAPK3 0 0 241 240 1 2
GRP GRM1 0 0 157 178 1 1
GRP SST 0 0 870 877 1 1
GRP AR 0 0 456 456 1 2
GRP RHOA 0 0 166 165 1 2
GRP ADM 0 0 325 325 1 2
GRP EPHA3 0 0 170 180 1 1
GRP SLITRK2 0 0 291 290 1 1
GRP GNRH1 0 500 454 715 1 1
GRP NMUR2 0 0 212 310 1 1
GRP FOLH1 0 0 594 594 1 1
GRP TTR 0 0 181 181 1 1
GRP PHOX2A 0 0 0 362 1 1
GRP SLC32A1 0 0 241 292 1 1
GRP SFTPB 0 0 107 297 1 1
GRP PYY 0 0 667 679 1 1
GRP CARTPT 0 0 325 351 1 1
GRP PLA2G1B 0 0 193 193 1 1
GRP IMMP2L 0 0 501 501 1 1
GRP SLC15A1 0 0 124 218 1 1
GRP TG 0 0 218 218 1 1
GRP ESR2 0 0 95 201 1 1
GRP QRFP 0 500 181 579 1 1
GRP NPSR1 0 0 154 153 1 1
GRP PMCH 0 500 48 590 1 1
GRP PROKR2 0 0 182 229 1 1
GRP SLC15A2 0 0 57 304 1 1
GRP APLNR 0 0 122 154 1 1
GRP GHSR 0 0 193 210 1 1
GRP THRB 0 0 358 358 1 1
GRP FOS 0 0 517 567 1 2
GRP ANK1 0 0 135 167 1 1
GRP GRB2 0 0 166 165 1 1
GRP PENK 0 0 203 280 1 1
GRP C1QL3 0 0 74 161 1 1
GRP IL31 0 0 297 345 1 1
GRP GHRH 0 0 557 557 1 1
GRP SSTR5 0 0 283 298 1 1
GRP SUCLG2 0 0 183 183 1 1
GRP PNMT 0 0 171 171 1 1
GRP ALX1 272 0 0 272 1 1
GRP VIPR1 0 0 358 358 1 1
GRP PDYN 0 0 606 614 1 1
GRP AVPR1A 0 0 108 245 1 1
GRP DCC 0 0 351 367 1 1
GRP UCHL1 0 0 310 325 1 2
GRP GPR119 0 0 233 232 1 1
GRP CALR 0 0 140 271 1 1
GRP ASCL1 0 0 149 173 1 1
GRP KRAS 0 0 181 181 1 2
GRP TACR2 0 0 161 189 1 1
GRP CRK 0 0 295 295 1 1
GRP PGPEP1 0 0 643 643 1 1
GRP TRPC7 0 0 688 688 1 1
GRP MMP2 0 0 171 171 1 2
GRP PTH 0 0 213 213 1 1
GRP GPBAR1 0 0 380 394 1 1
GRP SSTR3 0 0 172 190 1 1
GRP MRAP2 0 0 0 256 1 1
GRP ANXA1 0 500 88 524 1 1
GRP ERBB4 0 0 130 161 1 1
GRP NTSR2 0 0 370 397 1 1
GRP SRF 0 0 54 616 1 1
GRP MET 0 0 166 165 1 2
GRP PER2 0 0 362 375 1 1
GRP GPR83 0 0 148 166 1 1
GRP TFIP11 0 0 213 213 1 1
GRP ADCYAP1R1 0 0 135 185 1 1
GRP DPP9 0 0 136 165 1 1
GRP TACR1 0 0 506 512 1 1
GRP NPPB 0 0 373 515 1 1
GRP CALB1 0 0 413 610 1 1
GRP PSAPL1 0 0 0 245 1 1
GRP HRH3 0 0 140 170 1 1
GRP ITPR3 0 0 193 199 1 1
GRP GPR61 0 0 119 159 1 1
GRP JUN 0 0 252 253 1 2
GRP C10orf12 0 0 44 161 1 1
GRP UTS2 0 500 46 502 1 1
GRP MC1R 0 0 204 204 1 1
GRP GHRHR 0 0 384 384 1 1
GRP PER3 0 0 142 489 1 1
GRP CRHR1 0 0 136 180 1 1
GRP GCGR 0 0 166 218 1 1
GRP PLAUR 0 0 218 218 1 1
GRP ATP4A 0 0 294 307 1 1
GRP TACR3 0 0 184 203 1 1
GRP CNTNAP2 0 0 430 442 1 1
GRP TRPC6 0 0 241 240 1 1
GRP HSPB3 0 0 165 165 1 1
GRP MYCL 0 0 182 181 1 1
GRP CHAT 0 0 234 234 1 1
GRP PREP 0 0 432 432 1 1
GRP SYP 0 0 561 570 1 1
GRP PPY 0 0 710 710 1 1
GRP PRKD1 0 0 456 456 1 1
GRP CRH 0 0 560 570 1 1
GRP ACHE 0 0 155 154 1 2
GRP AVPR2 0 0 139 170 1 1
GRP GNA11 0 0 323 323 1 1
GRP TRPA1 0 0 391 414 1 1
GRP GNRH2 0 500 0 531 1 1
GRP POMC 0 0 710 710 1 1
GRP LYN 0 0 157 156 1 1
GRP SCTR 0 0 203 203 1 1
GRP VSTM2A 0 0 0 164 1 1
GRP ESR1 0 0 208 208 1 2
GRP GPR176 0 0 47 218 1 1
GRP NCL 270 0 75 295 1 2
GRP PRL 0 0 455 467 1 1
GRP CTSB 0 0 141 152 1 2
GRP IGFBP1 0 0 75 167 1 1
GRP EGF 0 0 519 519 1 2
GRP PCSK1 0 0 119 192 1 1
GRP QRFPR 0 0 90 161 1 1
GRP CDH9 0 0 0 162 1 1
GRP FN1 0 0 233 232 1 2
GRP VTN 0 0 163 163 1 1
GRP CASR 0 0 210 230 1 2
GRP SSTR1 0 0 252 301 1 1
GRP PCBP1 270 0 0 270 1 1
GRP TGM3 0 0 103 168 1 1
GRP PTK2 0 0 391 390 1 2
GRP NPS 0 500 341 656 1 1
GRP GAL 0 0 710 710 1 1
GRP CALCA 0 0 802 806 1 1
GRP NMUR1 0 0 166 218 1 1
GRP PRKCA 0 0 143 150 1 1
GRP TRPM8 0 0 218 218 1 1
GRP ENO2 0 0 802 806 1 1
GRP NCAM1 0 0 334 348 1 1
GRP VR1 0 0 505 529 1 1
GRP XCL1 0 500 0 503 1 1
GRP CALCRL 0 0 125 171 1 1
GRP ADAM17 0 0 143 178 1 1
GRP PXN 0 0 391 390 1 1
GRP NKX2-1 0 0 325 325 1 1
GRP NEUROD6 0 0 136 204 1 1
GRP PRLHR 0 0 208 208 1 1
GRP DPP4 213 0 335 466 1 1
GRP IL10 0 0 138 156 1 2
GRP DBH 0 0 294 294 1 1
GRP ZYX 0 0 357 357 1 1
GRP PTK7 0 0 242 241 1 1
GRP HTR7 0 0 181 281 1 1
GRP GLP2R 0 0 185 220 1 1
GRP NMBR 0 800 942 988 1 1
GRP HTR5A 0 0 74 158 1 1
GRP FNDC1 0 0 0 156 1 1
GRP MARCKS 0 0 212 212 1 1
GRP HTR2B 0 0 150 239 1 1
GRP TAC1 0 500 870 934 1 1
GRP AVP 0 500 324 708 1 1
GRP HTR1A 0 0 187 275 1 1
GRP BDKRB2 0 0 112 450 1 1
GRP DGCR14 0 0 162 161 1 1
GRP CCL23 0 500 0 499 1 1
GRP IAPP 0 0 465 465 1 2
GRP SYNGR4 0 0 0 271 1 1
GRP ANKFN1 0 0 89 513 1 1
GRP GPR133 0 0 60 309 1 1
GRP AGRP 0 0 360 360 1 1
GRP LHCGR 0 0 86 181 1 1
GRP CCL28 0 0 451 451 1 1
GRP CDH10 0 0 0 159 1 1
GRP IGF2 0 0 167 167 1 1
GRP MLN 0 500 684 835 1 2
GRP NMU 0 500 468 722 1 1
GRP GABRA2 0 0 72 199 1 1
GRP PLG 0 0 157 156 1 1
GRP GPR116 0 0 48 166 1 1
GRP CDH1 0 0 151 150 1 2
GRP GAD2 0 0 155 181 1 1
GRP SCG2 0 0 322 412 1 1
GRP SLC17A6 0 0 426 474 1 1
GRP RORB 0 0 184 189 1 1
GRP SLC12A2 0 0 164 235 1 1
GRP ENPP2 0 0 167 167 1 1
GRP NPPC 0 0 96 170 1 1
GRP NPY1R 0 0 210 210 1 1
GRP GIPR 0 0 163 215 1 1
GRP DDC 0 0 271 277 1 1
GRP CCKBR 0 0 519 545 1 1
GRP MRGPRX1 0 0 730 730 1 1
GRP CRY2 0 0 210 293 1 1
GRP SLC4A9 0 0 157 156 1 1
GRP MC2R 0 0 108 161 1 1
GRP SCT 0 0 768 768 1 1
GRP LEP 0 0 532 542 1 1
GRP KIT 0 0 160 159 1 2
GRP IGLL5 0 0 164 163 1 1
GRP LEPR 0 0 151 150 1 1
GRP MRGPRX2 0 0 74 229 1 1
GRP ALB 0 0 620 620 1 2
GRP KNG1 0 500 681 833 1 1
GRP FPR1 0 0 265 265 1 1
GRP CHL1 0 0 257 283 1 1
GRP VEGFA 0 0 390 390 1 2
GRP TRPV3 0 0 173 179 1 1
GRP FAP 0 0 184 201 1 2
GRP PVALB 0 0 165 183 1 1
GRP PTEN 0 0 181 181 1 2
GRP MME 0 0 425 424 1 1
GRP EDN2 0 500 95 528 1 1
GRP TBCD 0 0 292 292 1 1
GRP FHOD3 0 0 0 191 1 1
GRP PTK2B 0 0 204 204 1 1
GRP GIP 0 0 518 518 1 1
GRP PCSK2 0 0 55 154 1 1
GRP ENSG00000264813 0 0 162 161 1 1
GRP HGF 0 0 174 173 1 2
GRP TGFA 0 0 209 209 1 1
GRP HBEGF 0 0 242 241 1 1
GRP STAT3 0 0 209 209 1 2
GRP OPRM1 0 0 401 401 1 1
GRP NR1D1 0 0 167 207 1 2
GRP GHRL 0 500 784 887 1 1
GRP GABRA3 0 0 96 176 1 1
GRP SLC5A1 0 0 218 253 1 1
GRP PHOX2B 0 0 105 629 1 1
GRP GBA 0 0 570 570 1 1
GRP BHLHE22 0 0 367 433 1 1
GRP BRS3 0 800 969 994 1 1
GRP CHGB 0 0 289 306 1 1
GRP VGF 0 0 139 245 1 1
GRP GALR1 0 0 155 154 1 1
GRP TPSD1 0 0 0 156 1 1
GRP PROCA1 0 0 325 371 1 1
GRP CALCB 0 0 158 157 1 1
GRP LMX1B 0 0 150 168 1 1
GRP NMS 0 500 562 777 1 1
GRP SSTR4 0 0 134 191 1 1
GRP CCND1 0 0 162 161 1 2
GRP EDN3 0 500 396 685 1 1
GRP NTSR1 0 0 336 351 1 1
GRP TPSB2 0 0 0 156 1 1
GRP NPB 0 0 240 270 1 1
GRP PAM 0 0 233 289 1 1
GRP PNLIP 0 0 137 155 1 1
GRP NPW 0 0 181 181 1 1
GRP TRH 0 500 681 839 1 1
GRP DRD1 0 0 128 198 1 1
GRP NPFF 0 500 294 658 1 1
GRP PSCA 0 0 217 217 1 1
GRP TP53 0 0 261 261 1 2
GRP SAG 0 0 181 181 1 1
GRP SLC12A5 0 0 155 304 1 1
GRP SCN10A 0 0 268 296 1 1
GRP PROK2 0 500 391 769 1 1
GRP NTRK1 0 0 269 285 1 1
GRP CFTR 0 0 180 179 1 2
GRP EDNRA 0 0 259 612 1 1
GRP PER1 0 0 0 261 1 1
GRP TSLP 0 0 122 176 1 1
GRP SLC2A1 0 0 151 158 1 2
GRP MUC1 0 0 346 345 1 1
GRP PGR 0 0 123 154 1 1
GRP SCG3 0 0 142 251 1 1
GRP FFAR1 0 0 211 211 1 1
GRP ADRB2 0 0 166 165 1 1
GRP GPR39 0 0 204 531 1 1
GRP EGFR 0 0 459 459 1 2
GRP ARNTL 0 0 293 364 1 1
GRP PCSK1N 0 0 278 337 1 1
GRP CYTH3 0 0 588 588 1 1
GRP GPR150 0 0 62 192 1 1
GRP MEP1A 213 0 0 218 1 1
GRP IGF1 0 0 393 392 1 2
GRP BBS2 0 0 103 491 1 1
GRP ITGA3 0 0 383 382 1 2
GRP GRPR 213 800 990 998 1 1
GRP AREG 0 0 240 239 1 1
GRP NPY 0 0 739 743 1 1
GRP IFNW1 0 0 0 181 1 1
GRP SLC12A4 0 0 125 275 1 1
GRP F2RL1 0 0 107 205 1 1
GRP CNR1 0 0 211 228 1 1
GRP VASP 0 0 323 323 1 1
GRP SLC17A8 0 0 160 299 1 1
GRP MYCN 0 0 241 240 1 1
GRP TDO2 0 0 329 329 1 1
GRP FGF2 0 0 234 234 1 2
GRP IL31RA 0 0 252 366 1 1
GRP CHGA 0 0 681 687 1 1
GRP SYNGR2 0 0 0 207 1 1
GRP ATP12A 0 0 294 307 1 1
GRP NR0B1 0 0 283 282 1 1
GRP GCG 0 500 710 848 1 1
GRP SCG5 0 0 193 261 1 1
GRP STC1 0 0 324 323 1 1
GRP AGT 0 500 60 509 1 1
GRP NOG 0 0 0 195 1 1
GRP GPR37L1 0 0 493 515 1 1
GRP GNAQ 0 0 521 521 1 1
GRP CELA1 0 0 81 173 1 1
GRP NTS 0 500 859 928 1 1
GRP RBFOX3 0 0 184 220 1 1
GRP NMB 0 800 916 982 1 1
GRP PLCB2 0 0 162 161 1 1
GRP CEACAM5 0 0 662 662 1 1
GRP TPI1 0 0 249 248 1 1
GRP VCL 0 0 324 333 1 1
GRP TAC3 0 500 520 749 1 1
GRP GH1 0 0 156 155 1 1
GRP OSBP2 0 0 400 400 1 1
GRP KISS1R 0 0 112 150 1 1
GRP GPR151 0 0 150 376 1 1
GRP MYC 0 0 262 262 1 2
GRP HTR1F 0 0 113 177 1 1
GRP HTR2C 0 0 146 187 1 1
GRP CLPS 0 0 134 153 1 1
GRP HDC 0 0 166 172 1 1
GRP UTS2B 0 500 49 531 1 1
GRP PPIP5K1 0 0 137 159 1 1
GRP CD44 0 0 140 226 1 2
GRP BDNF 0 0 231 247 1 2
GRP CLOCK 0 0 211 328 1 2
GRP MC3R 0 0 193 193 1 1
GRP IGF1R 0 0 194 194 1 2
GRP GPR63 0 0 66 180 1 1
GRP C19orf48 0 0 151 150 1 1
GRP PLCB3 0 0 241 252 1 1
GRP PLCB1 0 0 202 202 1 1
GRP IFITM1 0 0 653 653 1 1
GRP ANKRD28 270 0 0 270 1 1
GRP OXTR 0 0 143 196 1 1
GRP TNF 0 0 230 229 1 2
GRP SLC18A2 0 0 161 161 1 1
GRP SLC6A5 0 0 113 155 1 1
GRP GAPDH 0 0 162 161 1 2
GRP SLC12A7 0 0 125 238 1 1
GRP SLC2A5 0 0 150 238 1 1
GRP BMX 0 0 231 230 1 1
GRP SCN5A 0 0 0 217 1 1
GRP COL1A2 0 0 292 292 1 1
GRP NTRK2 0 0 202 234 1 1
GRP MAP2K7 0 0 203 203 1 1
GRP CDH6 0 0 0 159 1 1
GRP VIP 0 0 834 843 1 1
GRP PROK1 0 500 0 537 1 1
GRP SCN9A 0 0 117 220 1 1
GRP GNRHR 0 0 151 170 1 1
GRP CALCR 0 0 108 177 1 1
GRP CA9 0 0 100 162 1 1
GRP PRKCG 0 0 373 386 1 1
GRP KISS1 0 500 171 567 1 1
GRP UCN 0 0 96 197 1 1
GRP ADCYAP1 0 0 520 564 1 1
GRP PTHLH 0 0 342 342 1 1
GRP KCNK1 0 0 45 194 1 1
GRP MAGEL2 0 0 49 276 1 1
GRP AKT1 0 0 325 325 1 2
GRP NPR1 0 0 425 424 1 1
GRP MEP1B 213 0 53 290 1 1
GRP OPRK1 0 0 134 193 1 1
GRP TH 0 0 408 420 1 2
GRP GPR64 0 0 62 161 1 1
GRP NPPA 0 0 155 154 1 1
GRP HSPD1 0 0 171 171 1 1
GRP RAPGEF4 0 0 171 171 1 1
GRP PNOC 0 0 143 165 1 1
GRP MRGPRD 0 0 420 442 1 1
GRP NGF 0 0 323 323 1 2
GRP ERBB2 0 0 390 390 1 2
GRP PROKR1 0 0 81 162 1 1
GRP SNED1 0 0 261 261 1 1
GRP PSAP 0 0 91 575 1 1
GRP SYNGR1 0 0 0 193 1 1
GRP SCGN 0 0 57 158 1 1
GRP CALB2 0 0 369 599 1 1
GRP EDNRB 0 0 306 306 1 1
GRP HRH2 0 0 234 280 1 1
GRP MBOAT4 0 0 166 172 1 1
GRP CCK 0 500 880 944 1 1
GRP SLC12A6 0 0 44 172 1 1
GRP GAST 0 500 874 935 1 1
GRP APOA4 0 0 235 235 1 1
GRP RAPGEF3 0 0 134 193 1 1
GRP CREB1 0 0 216 216 1 2
GRP SLC7A2 0 0 138 330 1 1
GRP MBOAT7 0 0 0 188 1 1
GRP GAD1 0 0 193 213 1 1
GRP NALCN 0 0 71 324 1 1
GRP IL6 0 0 282 282 1 2
GRP GPR37 0 0 397 725 1 1
GRP HRH1 0 0 391 415 1 1
GRP F2 0 500 66 516 1 1
GRP CXCR4 0 0 195 195 1 2
GRP HP 0 0 151 150 1 1
GRP SRC 0 0 540 540 1 2
GRP ADA 0 0 181 181 1 1
GRP OXT 0 500 560 770 1 1
GRP RHBDF1 0 0 170 169 1 1
GRP GPR1 0 0 537 537 1 1
GRP SAA1 0 500 0 499 1 1
GRP PSMC6 0 0 200 200 1 1
GRP CHRNA2 0 0 74 150 1 1
GRP CRY1 0 0 287 374 1 1
GRP MB 0 0 193 194 1 2
GRP PRKCD 0 0 194 194 1 2
GRP TRPV4 0 0 181 192 1 1
GRP CTNNB1 0 0 156 155 1 2
GRP HRAS 0 0 252 252 1 2
GRP NPVF 0 0 140 230 1 1
GRP TRIM13 0 0 233 232 1 1
GRP TRPV1 0 0 505 529 1 2
GRP APP 0 500 95 528 1 2
GRP KRT19 0 0 518 518 1 1
GRP HRH4 0 0 282 282 1 1
GRP TMEM37 0 0 235 235 1 1
GRP RHO 0 0 171 222 1 2
GRP MC4R 0 0 243 260 1 1
GRP F2R 0 0 162 161 1 1
GRP GPR101 0 0 138 156 1 1
GRP VIPR2 0 0 529 589 1 1
GRP DPP8 0 0 133 171 1 1
GRP KDR 0 0 164 163 1 2
GRP EDN1 0 500 455 715 1 1
GRP SYNPR 0 0 66 249 1 1
GRP NTN1 0 0 296 296 1 1
GRP TPSAB1 0 0 0 156 1 1
GRP IL1B 0 0 212 212 1 2
GRP UCN2 0 0 95 188 1 1
GRP CXCL8 0 0 260 260 1 2
GRP ASPN 0 0 0 152 1 1
GRP PAX2 0 0 213 241 1 1
GRP PEG3 0 0 210 210 1 2
GRP CTSL 0 0 108 169 1 2
GRP SLC17A7 0 0 112 198 1 1
GRP WNT7A 0 0 75 151 1 1
GRP DOCK1 0 0 327 327 1 1
GRP PRKD3 0 0 171 171 1 1
GRP KLK3 0 0 506 506 1 1
GRP TLX3 0 0 246 262 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005184 Molecular Function neuropeptide hormone activity enables IBA
GO:0005184 Molecular Function neuropeptide hormone activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0005102 Molecular Function signaling receptor binding enables NAS
GO:0043303 Biological Process mast cell degranulation involved_in ISS
GO:1903817 Biological Process negative regulation of voltage-gated potassium channel activity involved_in ISS
GO:1905151 Biological Process negative regulation of voltage-gated sodium channel activity involved_in ISS
GO:0007218 Biological Process neuropeptide signaling pathway involved_in IBA
GO:0007218 Biological Process neuropeptide signaling pathway acts_upstream_of_or_within IDA
GO:2000987 Biological Process positive regulation of behavioral fear response involved_in ISS
GO:0090277 Biological Process positive regulation of peptide hormone secretion involved_in ISS
GO:1900738 Biological Process positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway involved_in ISS
GO:1903942 Biological Process positive regulation of respiratory gaseous exchange involved_in ISS
GO:0036343 Biological Process psychomotor behavior involved_in IEA
GO:0043207 Biological Process response to external biotic stimulus involved_in IEA
GO:0007165 Biological Process signal transduction involved_in NAS
GO:0035176 Biological Process social behavior involved_in IEA
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IBA
GO:0005615 Cellular Component extracellular space located_in IDA
GO:0043005 Cellular Component neuron projection located_in ISS
GO:0098992 Cellular Component neuronal dense core vesicle located_in IEA
GO:0034774 Cellular Component secretory granule lumen located_in ISS
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Peptide hormone metabolism Reactome R-HSA-2980736
Signaling by GPCR Reactome R-HSA-372790
Class A/1 (Rhodopsin-like receptors) Reactome R-HSA-373076
Peptide ligand-binding receptors Reactome R-HSA-375276
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome R-HSA-381771
GPCR downstream signalling Reactome R-HSA-388396
Metabolism of proteins Reactome R-HSA-392499
Incretin synthesis, secretion, and inactivation Reactome R-HSA-400508
G alpha (q) signalling events Reactome R-HSA-416476
GPCR ligand binding Reactome R-HSA-500792
Gastric acid production (WP2596) WikiPathways WP2596_r122782
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_011525933 3 mRNA transcript variant X3 NC_000018 Reference
NM_002091 5 mRNA transcript variant 1 NC_000018 Reference
XM_017025712 2 mRNA transcript variant X1 NC_000018 Reference
NM_001012512 3 mRNA transcript variant 2 NC_000018 Reference
NM_001012513 3 mRNA transcript variant 3 NC_000018 Reference
XM_017025713 2 mRNA transcript variant X2 NC_000018 Reference
XM_017025714 2 mRNA transcript variant X4 NC_000018 Reference