NRBF2

nuclear receptor binding factor 2

General Information

Name	nuclear receptor binding factor 2
Alias	nuclear receptor-binding factor 2 comodulator of PPAR and RXR 1 comodulator of PPAR and RXR 2
Gene_family	PIK3C3 complex subunits
organism	Homo sapiens
entrez_id	29982
location	10q21.3
transcript_count	3
exon_count	5

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Apr 2022]

Stringdb Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)

nextProt May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).

Interactions

NCBI

Show entries

Search:


NRBF2	BioGRID	ORF1ab	GeneID	BioGRID	Proximity Label-MS
NRBF2	BioGRID	ORF1ab	GeneID	BioGRID	Proximity Label-MS
NRBF2	BioGRID	KBTBD4	GeneID	BioGRID	Proximity Label-MS
NRBF2	BioGRID	PIK3R4	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NRBF2	BioGRID	OVOL2	GeneID	BioGRID	Affinity Capture-MS
NRBF2	BioGRID	RAB14	GeneID	BioGRID	Affinity Capture-MS
NRBF2	BioGRID	ATL3	GeneID	BioGRID	Affinity Capture-MS
NRBF2	BioGRID	ATG14	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
NRBF2	BioGRID	SPTLC1	GeneID	BioGRID	Affinity Capture-MS
NRBF2	BioGRID	SEC24D	GeneID	BioGRID	Affinity Capture-MS

Showing 1 to 10 of 75 entries

StringDB

Show entries

Search:


NRBF2	DNTTIP2	0	208	208	1	1
NRBF2	MAPKAPK2	0	210	210	1	1
NRBF2	LIN9	0	459	459	1	1
NRBF2	TMEM39A	0	310	328	1	1
NRBF2	OXT	0	0	189	1	1
NRBF2	JMJD1C	0	467	509	1	1
NRBF2	MTOR	0	156	155	1	2
NRBF2	RHOU	270	0	270	1	1
NRBF2	SLITRK5	0	157	156	1	1
NRBF2	MTMR3	0	181	181	1	2

Showing 1 to 10 of 202 entries

Ontologies

ID	Category	Term	Effect	Evidence
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0006914	Biological Process	autophagy	involved_in	IBA
GO:0006914	Biological Process	autophagy	involved_in	IMP
GO:0034976	Biological Process	response to endoplasmic reticulum stress	involved_in	IEA
GO:0005776	Cellular Component	autophagosome	located_in	IEA
GO:0005737	Cellular Component	cytoplasm	located_in	IDA
GO:0031410	Cellular Component	cytoplasmic vesicle	located_in	IEA
GO:0005654	Cellular Component	nucleoplasm	located_in	TAS
GO:0035032	Cellular Component	phosphatidylinositol 3-kinase complex, class III	part_of	IDA

Pathways

Name	DB	ID
Generic Transcription Pathway	Reactome	R-HSA-212436
Nuclear Receptor transcription pathway	Reactome	R-HSA-383280
RNA Polymerase II Transcription	Reactome	R-HSA-73857
Gene expression (Transcription)	Reactome	R-HSA-74160
Alzheimer's disease (WP5124)	WikiPathways	WP5124_r123917
Alzheimer's disease and miRNA effects (WP2059)	WikiPathways	WP2059_r119468

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_030759	5	mRNA	transcript variant 1	NC_000010	Reference
NM_001282405	2	mRNA	transcript variant 2	NC_000010	Reference
XM_047425132	1	mRNA	transcript variant X1	NC_000010	Reference