NRG1

neuregulin 1
General Information
Name neuregulin 1
Alias
  • pro-neuregulin-1, membrane-bound isoform
  • acetylcholine receptor-inducing activity
  • glial growth factor 2
  • heregulin, alpha (45kD, ERBB2 p185-activator)
  • neu differentiation factor
  • pro-NRG1
  • sensory and motor neuron derived factor
Synonyms HRG NDF GGF ARIA GGF2 HGL HRG1 HRGA MST131 MSTP131 NRG1-IT2 SMDF
Gene_family Neuregulins|I-set domain containing
organism Homo sapiens
entrez_id 3084
location 8p12
transcript_count 28
exon_count 19
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
      Stringdb Pro-neuregulin-1, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gla [...]
      nextProt May play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    NRG1 BioGRID YWHAZ GeneID BioGRID Cross-Linking-MS (XL-MS)
    NRG1 BioGRID FBXO22 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID PRNP GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC25A16 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID UGT8 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID NEK4 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SREBF2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SPINT1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SCNN1A GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID MGST3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID HLA-DRB1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID HLA-C GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ERBB3 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    NRG1 BioGRID DAD1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ATP7B GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC25A4 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID KIAA2013 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMTC4 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID POMGNT2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SFXN3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID OPA3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID PGAP1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID GALNT12 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC25A23 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID GALNT11 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID PLXNA3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMEM63B GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMEM39B GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC35F6 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID DNAAF5 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID LSR GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID GLOD4 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID DSE GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID B3GAT3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID INTS7 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ZDHHC17 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMEM131L GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ADGRL1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID RHOBTB3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID B4GALT7 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID GALNT5 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID B3GNT2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID POMT1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SEMA6B GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID B3GNT3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC25A15 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID CHST10 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID HS6ST1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID CISD2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC35B2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID B3GALNT2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID LARGE2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SFXN2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ORF7b GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ORF3b GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ORF7b GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ORF3a GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID H2BC9 GeneID BioGRID Proximity Label-MS
    NRG1 BioGRID TMEM54 GeneID BioGRID Two-hybrid
    NRG1 BioGRID JAGN1 GeneID BioGRID Two-hybrid
    NRG1 BioGRID LAPTM4B GeneID BioGRID Two-hybrid
    NRG1 BioGRID MS4A4A GeneID BioGRID Two-hybrid
    NRG1 BioGRID PLP1 GeneID BioGRID Two-hybrid
    NRG1 BioGRID CD72 GeneID BioGRID Two-hybrid
    NRG1 BioGRID ASGR2 GeneID BioGRID Two-hybrid
    NRG1 BioGRID NRAS GeneID BioGRID Proximity Label-MS
    NRG1 BioGRID CALY GeneID BioGRID Affinity Capture-Western
    NRG1 BioGRID Erbb4 GeneID BioGRID Co-localization
    NRG1 BioGRID TMEM164 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TM2D3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID CNTNAP3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID MBOAT7 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID LGR4 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID LEMD3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID GLMN GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TUBB3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC67A1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID HLA-DPB1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID CDC5L GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID EGFR GeneID BioGRID Affinity Capture-Western; PCA; Two-hybrid
    NRG1 BioGRID DDX11L8 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMEM205 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMTC3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID PIGU GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SLC38A10 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID NETO2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID MYO19 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID FAM234B GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID TMEM181 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID RNF130 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID RDH11 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID C1GALT1C1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID UQCRQ GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID MTCH1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ABCB10 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID SPTLC2 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID DEGS1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID NDUFA3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID MGAT1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID HMOX1 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID EXTL3 GeneID BioGRID Affinity Capture-MS
    NRG1 BioGRID ABCA3 GeneID BioGRID Affinity Capture-MS
    NRG1 Protein IKZF4 GeneID HPRD None
    NRG1 Protein ADAM19 GeneID HPRD None
    NRG1 Protein LIMK1 GeneID HPRD None
    NRG1 Protein ERBB4 GeneID HPRD None
    NRG1 Protein ERBB3 GeneID HPRD None
    NRG1 Protein EGF GeneID HPRD None
    NRG1 BioGRID ERBB4 GeneID BioGRID Reconstituted Complex
    NRG1 BioGRID LIMK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    NRG1 BioGRID ERBB2 GeneID BioGRID Reconstituted Complex
    NRG1 None None None BIND Nrg-1 interacts with Eos. This interaction was modeled on a demonstrated interaction between Nrg-1 from an unspecified species and Eos from an unspecified species.
    NRG1 None None None BIND Nrg-1 interacts with PSD-95 promoter. This interaction was modeled on a demonstrated interaction between Nrg-1 from an unspecified species and human PSD-95 promoter.
    NRG1 Protein ERBB3 GeneID BIND NDF-alpha interacts with Her3. An interaction between human NDF-alpha and Her3 from an unknown species was demonstrated by experimental system.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    NRG1 ARL1 0 0 81 209 1 1
    NRG1 ERBB2IP 0 900 261 925 1 1
    NRG1 WNT2B 0 0 125 165 1 1
    NRG1 DDR2 0 0 212 228 1 1
    NRG1 VIPR2 0 0 134 169 1 1
    NRG1 TMEM132E 0 0 0 190 1 1
    NRG1 MS4A4A 272 0 0 272 1 1
    NRG1 CACNA1C 0 0 341 341 1 1
    NRG1 HCN4 0 0 161 185 1 1
    NRG1 CACNA2D2 0 0 54 271 1 1
    NRG1 CTNNB1 0 0 326 344 1 1
    NRG1 HRAS 0 900 401 943 1 1
    NRG1 ASTN1 0 0 213 213 1 1
    NRG1 APP 63 0 504 528 1 1
    NRG1 EPHA2 0 0 145 181 1 1
    NRG1 EGR1 0 0 287 292 1 1
    NRG1 SCN1A 0 0 169 193 1 1
    NRG1 TMEM181 183 0 0 183 1 1
    NRG1 PRDM11 0 0 234 234 1 1
    NRG1 CXCL8 0 0 211 217 1 1
    NRG1 GRIK3 0 0 210 210 1 1
    NRG1 WNT7A 0 0 143 158 1 1
    NRG1 NDST3 0 0 112 224 1 1
    NRG1 BAI3 0 0 0 424 1 1
    NRG1 RASGEF1A 0 0 181 181 1 1
    NRG1 POMT1 211 0 0 211 1 1
    NRG1 ISL1 0 0 294 342 1 1
    NRG1 HIF1A 0 0 210 244 1 2
    NRG1 EDN1 0 0 325 360 1 1
    NRG1 POSTN 0 0 323 490 1 1
    NRG1 NEDD4 0 0 143 175 1 2
    NRG1 DLG2 0 500 351 661 1 1
    NRG1 IL1B 0 0 547 547 1 1
    NRG1 LGR4 129 0 0 208 1 1
    NRG1 CPNE3 0 0 73 171 1 1
    NRG1 DOCK7 0 900 157 912 1 1
    NRG1 EGFL8 0 0 74 189 1 1
    NRG1 UNC5C 0 0 157 156 1 1
    NRG1 NPHS1 0 0 45 164 1 1
    NRG1 TBX2 0 0 140 163 1 1
    NRG1 PLEK 0 0 183 194 1 1
    NRG1 MPZ 0 0 520 593 1 1
    NRG1 CTRL 0 0 113 150 1 1
    NRG1 MSC 0 0 123 174 1 1
    NRG1 MOG 0 0 240 239 1 1
    NRG1 GRM7 0 0 254 254 1 1
    NRG1 IL6 0 0 491 504 1 1
    NRG1 NPAS2 0 0 96 342 1 1
    NRG1 MTOR 0 0 254 275 1 2
    NRG1 RPL13A 0 0 81 174 1 1
    NRG1 GABRA1 0 650 155 698 1 1
    NRG1 TBR1 0 0 167 167 1 1
    NRG1 PTPRU 0 0 108 167 1 1
    NRG1 POTEF 0 0 134 172 1 1
    NRG1 JARID2 0 0 134 162 1 1
    NRG1 PDE8B 0 0 185 199 1 1
    NRG1 OPA3 183 0 0 183 1 1
    NRG1 NRP2 0 0 107 164 1 1
    NRG1 FGF13 0 0 406 406 1 1
    NRG1 PSEN2 0 0 206 220 1 1
    NRG1 CYR61 0 0 182 257 1 1
    NRG1 CXCR4 0 0 213 214 1 2
    NRG1 MMP1 0 0 95 155 1 1
    NRG1 PTPN13 0 0 113 190 1 1
    NRG1 NOTCH1 0 0 528 541 1 1
    NRG1 GABRB2 0 650 266 748 1 1
    NRG1 TM2D3 216 0 0 216 1 1
    NRG1 MSH5 0 0 52 404 1 1
    NRG1 L1CAM 0 0 143 327 1 1
    NRG1 DIAPH1 0 600 0 600 1 1
    NRG1 RGS4 0 0 637 650 1 1
    NRG1 CUL7 0 0 0 231 1 1
    NRG1 DTNA 0 0 154 153 1 1
    NRG1 WNT11 0 0 152 151 1 1
    NRG1 RELN 0 0 518 526 1 1
    NRG1 NAV1 0 0 327 327 1 1
    NRG1 SYNGR1 0 0 157 156 1 1
    NRG1 EPO 0 0 147 173 1 1
    NRG1 ANXA5 0 0 161 165 1 1
    NRG1 ZDHHC17 217 0 53 242 1 1
    NRG1 NPPA 0 0 194 208 1 1
    NRG1 CCNB1 0 0 135 163 1 1
    NRG1 TMTC3 179 0 0 179 1 1
    NRG1 FGF21 0 0 59 169 1 1
    NRG1 GRIA2 0 0 180 179 1 1
    NRG1 MYT1L 0 0 161 181 1 1
    NRG1 GRIA4 0 0 146 204 1 1
    NRG1 NRG2 0 900 797 912 1 1
    NRG1 CACNA2D4 0 0 0 161 1 1
    NRG1 HOPX 0 0 135 153 1 1
    NRG1 IFNG 0 0 150 181 1 2
    NRG1 WWP1 0 900 91 905 1 1
    NRG1 FGF14 0 0 142 194 1 1
    NRG1 NLGN3 0 0 180 179 1 1
    NRG1 CADM3 0 0 242 289 1 1
    NRG1 TGFB3 0 0 137 196 1 1
    NRG1 MBOAT7 210 0 0 227 1 1
    NRG1 CREB1 0 0 322 321 1 1
    NRG1 NOTCH4 0 0 253 268 1 1
    NRG1 PRKACA 0 900 0 900 1 1
    NRG1 CALB2 0 0 293 293 1 1
    NRG1 HLA-DPB1 234 0 59 248 1 1
    NRG1 RYR2 0 0 216 251 1 1
    NRG1 IGFBP5 0 0 163 169 1 1
    NRG1 LRSAM1 0 0 0 203 1 2
    NRG1 FIG4 0 0 159 189 1 1
    NRG1 POU3F2 0 0 270 285 1 1
    NRG1 GDF9 0 0 75 172 1 1
    NRG1 CREBBP 0 0 156 155 1 1
    NRG1 DGCR8 0 0 124 160 1 1
    NRG1 NEFM 0 0 134 229 1 1
    NRG1 KCNB1 0 0 112 167 1 2
    NRG1 SLC18A3 0 0 241 241 1 1
    NRG1 JAG2 0 0 160 183 1 1
    NRG1 ABL1 0 0 180 179 1 1
    NRG1 PROK1 0 0 322 326 1 1
    NRG1 NF1 0 0 296 306 1 1
    NRG1 CSMD1 0 0 210 210 1 1
    NRG1 CPA4 0 0 44 191 1 1
    NRG1 CX3CL1 0 0 170 200 1 1
    NRG1 MAP2K7 0 0 412 412 1 1
    NRG1 SMAD2 0 0 134 166 1 1
    NRG1 TLR4 0 0 134 187 1 1
    NRG1 TMBIM4 0 0 120 151 1 1
    NRG1 HTR3A 0 0 181 216 1 1
    NRG1 FGFR2 0 0 359 378 1 1
    NRG1 WWC1 0 0 181 181 1 1
    NRG1 OLIG1 0 0 325 334 1 1
    NRG1 EGR3 0 0 402 402 1 1
    NRG1 GAPDH 0 0 401 401 1 2
    NRG1 TMEM63B 193 0 0 193 1 1
    NRG1 TENM4 0 0 272 277 1 1
    NRG1 HIRA 0 0 163 163 1 1
    NRG1 NAB1 0 0 193 193 1 1
    NRG1 GJB1 0 0 260 260 1 1
    NRG1 BNC2 0 0 66 163 1 1
    NRG1 PRODH 0 0 467 467 1 1
    NRG1 BCL2L1 0 0 181 181 1 2
    NRG1 KITLG 0 0 212 212 1 1
    NRG1 CACNA1G 0 0 94 159 1 1
    NRG1 PI15 0 0 86 219 1 1
    NRG1 PDE3A 0 0 101 161 1 1
    NRG1 CALY 270 0 124 333 1 1
    NRG1 GAB2 0 0 181 181 1 1
    NRG1 SBNO2 0 0 66 262 1 1
    NRG1 WWTR1 0 0 171 171 1 1
    NRG1 NCAN 0 0 155 186 1 1
    NRG1 PIK3CA 0 900 368 936 1 2
    NRG1 HHIP 0 0 81 173 1 1
    NRG1 DSE 228 0 0 294 1 1
    NRG1 TMEM132A 0 0 0 175 1 1
    NRG1 TMEM132D 0 0 0 248 1 1
    NRG1 NOG 0 0 180 179 1 1
    NRG1 P4HB 0 0 119 152 1 2
    NRG1 SCN2A 0 0 120 193 1 1
    NRG1 SEMA6A 0 0 324 323 1 1
    NRG1 HS6ST1 228 0 47 232 1 1
    NRG1 TBX5 0 0 321 325 1 1
    NRG1 KALRN 0 0 376 376 1 1
    NRG1 USF1 0 0 411 411 1 1
    NRG1 TAB2 0 0 384 384 1 1
    NRG1 IGF1R 0 0 324 366 1 1
    NRG1 NLGN2 0 0 138 161 1 1
    NRG1 PPARGC1A 0 0 202 202 1 1
    NRG1 FGF10 0 0 273 283 1 1
    NRG1 TPH1 0 0 172 186 1 1
    NRG1 FGFBP1 0 0 180 215 1 1
    NRG1 ADAM10 0 0 379 391 1 1
    NRG1 FABP7 0 0 265 265 1 1
    NRG1 SLC1A3 0 0 195 195 1 1
    NRG1 MYC 0 0 322 321 1 2
    NRG1 NCSTN 0 0 280 280 1 1
    NRG1 TMEFF2 0 0 123 167 1 1
    NRG1 PARK2 0 0 81 179 1 1
    NRG1 ILK 0 0 126 199 1 1
    NRG1 WNT5A 0 0 212 235 1 1
    NRG1 CLOCK 0 0 113 207 1 2
    NRG1 SLC6A4 0 0 390 390 1 1
    NRG1 BRCA1 0 0 180 185 1 1
    NRG1 STK11 0 0 150 175 1 2
    NRG1 GRIN3B 0 0 166 174 1 1
    NRG1 PIP4K2A 0 0 212 212 1 2
    NRG1 FURIN 0 0 170 169 1 1
    NRG1 NPY 0 0 241 240 1 1
    NRG1 AREG 0 0 601 625 1 1
    NRG1 RTN4RL2 0 0 193 207 1 1
    NRG1 RTN2 0 0 308 307 1 1
    NRG1 BTC 0 500 602 807 1 1
    NRG1 PLXNA2 0 0 171 191 1 1
    NRG1 MAP2K1 0 900 293 930 1 1
    NRG1 GDAP1 0 0 96 178 1 1
    NRG1 NEGR1 0 0 113 203 1 1
    NRG1 CYTL1 0 0 55 270 1 1
    NRG1 MECP2 0 0 195 195 1 1
    NRG1 PPP1R1B 0 0 235 305 1 1
    NRG1 MTMR2 0 0 261 311 1 1
    NRG1 SCUBE3 0 0 108 220 1 1
    NRG1 FRS2 0 0 141 160 1 1
    NRG1 EML4 0 0 367 367 1 1
    NRG1 TAAR6 0 0 322 321 1 1
    NRG1 SEMA4C 0 0 285 284 1 1
    NRG1 CAPZB 0 0 143 178 1 1
    NRG1 DUSP4 0 0 150 173 1 1
    NRG1 EFNA5 0 0 156 155 1 1
    NRG1 TTN 0 0 167 167 1 1
    NRG1 PPP3CC 0 0 468 468 1 1
    NRG1 SMAD4 0 0 206 206 1 1
    NRG1 SLC6A1 0 0 242 247 1 1
    NRG1 DLX2 0 0 233 249 1 1
    NRG1 LRRC23 0 0 108 160 1 1
    NRG1 SYCE2 0 0 53 424 1 1
    NRG1 LEMD3 210 0 0 210 1 1
    NRG1 HDAC2 0 0 120 152 1 1
    NRG1 SELPLG 0 0 230 229 1 1
    NRG1 EMX1 0 0 171 171 1 1
    NRG1 GABRA5 0 0 144 162 1 1
    NRG1 NOL6 0 0 52 151 1 1
    NRG1 CAPNS2 0 0 261 261 1 1
    NRG1 PLP1 129 0 284 349 1 1
    NRG1 VPS4B 0 0 279 279 1 1
    NRG1 LINGO1 0 0 213 251 1 1
    NRG1 POX2 0 0 505 505 1 1
    NRG1 BCAS3 0 0 355 355 1 2
    NRG1 P2RX4 0 0 123 168 1 1
    NRG1 PTPRD 0 0 181 254 1 1
    NRG1 PITX2 0 0 140 168 1 1
    NRG1 RAF1 0 0 189 189 1 2
    NRG1 ADAMTS1 0 0 182 200 1 1
    NRG1 FGF7 0 0 329 344 1 1
    NRG1 BOP1 0 0 373 373 1 1
    NRG1 RALGAPA1 0 0 57 203 1 1
    NRG1 NELL2 0 0 123 163 1 1
    NRG1 EDN3 0 0 324 323 1 1
    NRG1 NRXN3 0 0 241 240 1 1
    NRG1 GALNT11 224 0 0 224 1 1
    NRG1 FGFR3 0 0 325 345 1 1
    NRG1 CHSY3 0 0 118 175 1 1
    NRG1 LAMP1 0 0 72 173 1 2
    NRG1 CDK4 0 0 163 169 1 1
    NRG1 EGFR 690 900 989 999 1 1
    NRG1 AADAT 0 0 195 195 1 1
    NRG1 MDM2 0 0 123 155 1 1
    NRG1 SLC12A5 0 0 218 218 1 1
    NRG1 TP53 0 0 334 349 1 2
    NRG1 FBLN2 0 0 0 164 1 1
    NRG1 MAOA 0 0 228 241 1 1
    NRG1 DHH 0 0 246 279 1 1
    NRG1 LRIG1 0 900 75 909 1 1
    NRG1 PTN 0 0 149 188 1 1
    NRG1 TGFA 0 0 325 334 1 1
    NRG1 B4GALT6 0 0 173 173 1 1
    NRG1 SEMA3B 0 0 310 309 1 1
    NRG1 GDNF 0 0 603 603 1 1
    NRG1 STAT3 0 0 306 324 1 2
    NRG1 ADAM9 0 0 134 166 1 1
    NRG1 RHBDL3 0 0 0 206 1 1
    NRG1 MST1 0 0 91 253 1 1
    NRG1 HBEGF 0 500 601 811 1 1
    NRG1 GSX2 0 0 164 203 1 1
    NRG1 FREM2 0 0 74 163 1 1
    NRG1 PTPRT 0 0 103 162 1 1
    NRG1 TCF21 0 0 123 215 1 1
    NRG1 NLGN4X 0 0 170 169 1 1
    NRG1 CHRFAM7A 0 0 134 183 1 1
    NRG1 NF2 0 0 458 464 1 1
    NRG1 KRT5 0 0 140 159 1 1
    NRG1 MYH6 0 0 310 309 1 1
    NRG1 FREM3 0 0 117 273 1 1
    NRG1 SEMA3D 0 0 325 325 1 1
    NRG1 CLU 0 0 157 156 1 2
    NRG1 NLGN1 0 0 193 210 1 1
    NRG1 TMEM132C 0 0 62 406 1 1
    NRG1 CISD2 204 0 0 204 1 2
    NRG1 ATP2B4 0 0 94 157 1 1
    NRG1 SEMA3C 0 0 324 343 1 1
    NRG1 JAK2 0 900 162 913 1 1
    NRG1 POLR3B 0 0 57 226 1 1
    NRG1 LGI4 0 0 357 357 1 1
    NRG1 FAM180A 0 0 84 180 1 1
    NRG1 CDH2 0 0 268 314 1 1
    NRG1 PTX3 0 0 150 182 1 1
    NRG1 CHRNA3 0 0 181 187 1 1
    NRG1 SMAD3 0 0 142 157 1 1
    NRG1 CTNNA3 0 0 125 258 1 1
    NRG1 CNTF 0 0 417 416 1 1
    NRG1 NEU2 0 0 154 153 1 1
    NRG1 TUBB3 130 0 171 268 1 1
    NRG1 SERPINF1 0 0 162 180 1 1
    NRG1 VAMP2 0 0 242 242 1 1
    NRG1 DAG1 0 0 156 162 1 1
    NRG1 NRCAM 0 0 245 261 1 1
    NRG1 NUMB 0 0 150 174 1 1
    NRG1 PDGFRB 0 0 260 300 1 1
    NRG1 IMPA2 0 0 154 153 1 1
    NRG1 SLC30A1 0 0 54 153 1 1
    NRG1 CDK5 0 0 218 218 1 2
    NRG1 ITGB1 0 0 181 261 1 1
    NRG1 PVALB 0 0 596 601 1 1
    NRG1 FAP 0 0 157 178 1 1
    NRG1 SORBS3 0 0 74 280 1 1
    NRG1 ADRB3 0 0 96 233 1 1
    NRG1 MME 0 0 134 153 1 1
    NRG1 SNPH 0 0 67 162 1 1
    NRG1 CARD17 0 0 75 216 1 1
    NRG1 SNAI2 0 0 149 208 1 1
    NRG1 CDC37 0 900 0 900 1 1
    NRG1 CCL2 0 0 218 232 1 2
    NRG1 ALB 0 0 264 391 1 1
    NRG1 UTRN 0 0 171 222 1 1
    NRG1 SERTAD3 0 0 181 181 1 1
    NRG1 HTR1A 0 0 210 221 1 1
    NRG1 FETUB 0 0 0 248 1 1
    NRG1 IL1A 0 0 166 188 1 1
    NRG1 CUX1 0 0 194 194 1 1
    NRG1 ABCA1 0 0 66 209 1 1
    NRG1 GABRB1 0 650 122 721 1 1
    NRG1 ALK 0 0 460 459 1 1
    NRG1 BMP10 0 0 391 475 1 1
    NRG1 WNT1 0 0 281 281 1 1
    NRG1 PAX6 0 0 203 203 1 1
    NRG1 GLMN 209 0 44 269 1 1
    NRG1 NR3C2 0 0 181 181 1 1
    NRG1 SLC3A2 0 0 451 451 1 1
    NRG1 DRD2 0 0 470 483 1 1
    NRG1 EREG 417 500 595 881 1 1
    NRG1 PDE4A 0 0 270 270 1 1
    NRG1 RBM19 0 0 134 369 1 1
    NRG1 SMARCE1 0 0 45 185 1 1
    NRG1 CSN2 0 0 74 161 1 1
    NRG1 MAF 0 0 181 181 1 1
    NRG1 LGALS4 0 0 183 183 1 1
    NRG1 GFRA2 0 0 160 159 1 1
    NRG1 PDGFRA 0 0 280 301 1 1
    NRG1 ZEB2 0 0 218 246 1 1
    NRG1 FGF17 0 0 184 235 1 1
    NRG1 CDH1 0 0 211 254 1 1
    NRG1 NEUROG2 0 0 193 203 1 1
    NRG1 NRG4 0 800 664 930 1 1
    NRG1 HOXB2 0 0 294 308 1 1
    NRG1 BAI2 0 0 0 424 1 1
    NRG1 CNTNAP1 0 0 234 328 1 1
    NRG1 EPHA4 0 0 202 241 1 1
    NRG1 FBXL20 0 0 66 207 1 1
    NRG1 NEFL 0 500 193 588 1 1
    NRG1 BLMH 0 0 306 306 1 1
    NRG1 PDE4D 0 0 166 182 1 1
    NRG1 FGF18 0 0 120 175 1 1
    NRG1 BRAF 0 0 211 211 1 1
    NRG1 RBPMS 0 0 171 171 1 1
    NRG1 ACTN2 0 500 67 517 1 1
    NRG1 TBX3 0 0 181 212 1 1
    NRG1 PDE1C 0 0 45 158 1 1
    NRG1 PHLDA1 0 0 134 157 1 1
    NRG1 GYLTL1B 214 0 0 214 1 1
    NRG1 PCM1 0 0 91 230 1 1
    NRG1 PSPN 0 0 301 301 1 1
    NRG1 PTK2 0 0 240 253 1 1
    NRG1 NANOS3 0 0 89 346 1 1
    NRG1 SHANK2 0 0 151 150 1 1
    NRG1 VIM 0 0 150 223 1 1
    NRG1 ZDHHC8 0 0 369 405 1 1
    NRG1 GGT5 0 0 159 158 1 1
    NRG1 ADAM11 0 0 97 162 1 1
    NRG1 GRB7 0 600 187 663 1 1
    NRG1 MAPK8 0 900 108 908 1 2
    NRG1 ZNF467 0 0 0 187 1 1
    NRG1 CTGF 0 0 252 286 1 1
    NRG1 CCDC6 0 0 208 208 1 1
    NRG1 NR3C1 0 0 157 156 1 1
    NRG1 PDGFA 0 0 243 242 1 1
    NRG1 GRM3 0 0 556 556 1 1
    NRG1 MEST 0 0 48 150 1 1
    NRG1 SSH1 0 0 62 259 1 1
    NRG1 CLDN11 0 0 143 161 1 1
    NRG1 HIST2H3PS2 0 0 209 209 1 1
    NRG1 LHX8 0 0 91 165 1 1
    NRG1 MESP1 0 0 136 151 1 1
    NRG1 NES 0 0 324 335 1 1
    NRG1 KCNJ16 0 0 350 349 1 1
    NRG1 ACHE 0 0 184 183 1 1
    NRG1 TEK 0 0 162 205 1 1
    NRG1 SRGAP1 0 0 0 189 1 1
    NRG1 LIN7C 0 0 290 290 1 1
    NRG1 PER3 0 0 117 150 1 1
    NRG1 ST6GALNAC5 0 0 140 161 1 1
    NRG1 LIF 0 0 217 218 1 1
    NRG1 GATA4 0 0 320 351 1 2
    NRG1 ETV5 0 0 181 181 1 1
    NRG1 GPHN 0 0 143 173 1 1
    NRG1 CSPG5 0 0 180 179 1 1
    NRG1 PTPRK 0 0 73 152 1 1
    NRG1 PIK3R1 0 900 161 912 1 1
    NRG1 CX3CR1 0 0 113 168 1 1
    NRG1 ATP6AP2 0 0 0 216 1 1
    NRG1 BMP2 0 0 218 226 1 1
    NRG1 EGF 658 500 839 972 1 1
    NRG1 NRXN2 0 0 210 210 1 1
    NRG1 SP4 0 0 171 228 1 1
    NRG1 TMEM196 0 0 95 175 1 1
    NRG1 POLR2D 0 0 48 213 1 1
    NRG1 IGFBP1 0 0 142 165 1 1
    NRG1 SLC6A11 0 0 155 162 1 1
    NRG1 NANOG 0 0 153 181 1 1
    NRG1 SLC1A2 0 0 218 218 1 1
    NRG1 VCAN 0 0 170 193 1 1
    NRG1 DUSP12 0 0 99 155 1 1
    NRG1 NRP1 0 0 170 202 1 1
    NRG1 AIF1 0 0 232 231 1 1
    NRG1 CHRNA7 0 0 391 426 1 1
    NRG1 SRF 0 0 208 259 1 1
    NRG1 CAV1 0 0 146 177 1 1
    NRG1 ERBB4 786 900 989 999 1 1
    NRG1 PIK3CG 0 0 150 150 1 1
    NRG1 PTPN21 0 0 74 161 1 1
    NRG1 SLC8A1 0 0 135 158 1 1
    NRG1 BOK 0 0 0 189 1 2
    NRG1 SNCA 0 0 141 188 1 2
    NRG1 CD74 0 0 407 407 1 1
    NRG1 KLK8 0 0 210 294 1 1
    NRG1 DNTT 0 0 157 156 1 1
    NRG1 SEZ6L 0 0 155 183 1 1
    NRG1 RTN4R 0 0 287 350 1 1
    NRG1 CCNA2 0 0 150 216 1 1
    NRG1 CASP1 0 0 57 201 1 2
    NRG1 NOS1 0 0 167 167 1 1
    NRG1 C3orf58 0 0 110 205 1 1
    NRG1 RYK 0 0 57 260 1 1
    NRG1 NRG3 0 900 754 938 1 1
    NRG1 PLCG1 0 650 125 693 1 1
    NRG1 SLC22A18 274 0 0 274 1 1
    NRG1 JUN 0 0 325 338 1 1
    NRG1 CNTNAP4 0 0 63 179 1 1
    NRG1 MYL7 0 0 66 161 1 1
    NRG1 PLCB4 0 0 127 161 1 1
    NRG1 CDH17 0 0 182 192 1 1
    NRG1 NPPB 0 0 262 262 1 1
    NRG1 DLL4 0 0 142 159 1 1
    NRG1 BCL2L11 0 0 134 157 1 1
    NRG1 TMTC4 207 0 0 207 1 1
    NRG1 DSCAM 0 0 181 240 1 1
    NRG1 DPYSL2 0 0 249 248 1 1
    NRG1 CYP19A1 0 0 123 198 1 1
    NRG1 PHF13 0 0 66 233 1 1
    NRG1 TBX20 0 0 242 261 1 1
    NRG1 GRIN2C 0 900 443 941 1 1
    NRG1 CALB1 0 0 261 261 1 1
    NRG1 TMEM39B 226 0 94 268 1 1
    NRG1 SOD1 0 0 218 218 1 1
    NRG1 FGF6 0 0 112 222 1 1
    NRG1 SHH 0 0 322 351 1 1
    NRG1 MYRF 0 0 294 294 1 1
    NRG1 GRIN2A 0 900 426 940 1 1
    NRG1 RTN1 0 0 295 295 1 1
    NRG1 FYN 0 900 294 928 1 1
    NRG1 GRB2 0 900 294 928 1 1
    NRG1 PENK 0 0 118 177 1 1
    NRG1 NKX2-2 0 0 162 179 1 1
    NRG1 FST 0 0 141 158 1 1
    NRG1 JAG1 0 0 288 317 1 1
    NRG1 SNAPC4 0 0 216 216 1 1
    NRG1 CRK 0 0 140 179 1 1
    NRG1 ETV1 0 0 218 218 1 1
    NRG1 NFATC3 0 0 539 539 1 1
    NRG1 ID4 0 0 134 198 1 1
    NRG1 GRIN2D 0 500 175 581 1 1
    NRG1 INTS7 216 0 0 216 1 1
    NRG1 ANGPT2 0 0 207 207 1 1
    NRG1 NOS1AP 0 0 375 375 1 1
    NRG1 BASP1 0 0 107 187 1 1
    NRG1 VSNL1 0 0 171 171 1 1
    NRG1 CADM4 0 0 253 289 1 1
    NRG1 MMP2 0 0 165 185 1 1
    NRG1 AGRN 0 0 554 557 1 1
    NRG1 POLR3D 0 0 42 212 1 1
    NRG1 VWA5B1 0 0 137 176 1 1
    NRG1 IGFBP3 0 0 150 192 1 1
    NRG1 SEMA3G 0 0 283 282 1 1
    NRG1 APBB1 0 0 351 351 1 1
    NRG1 UCHL1 0 0 123 392 1 1
    NRG1 GAP43 0 0 275 298 1 1
    NRG1 BMP6 0 0 128 151 1 1
    NRG1 TIMP1 0 0 202 202 1 1
    NRG1 FGF4 0 0 181 198 1 1
    NRG1 POU3F1 0 0 374 411 1 1
    NRG1 CXCL12 0 0 324 328 1 1
    NRG1 IMMP2L 0 0 170 169 1 1
    NRG1 TNNI3 0 0 166 165 1 1
    NRG1 SYN1 0 0 162 180 1 1
    NRG1 ETV4 0 0 155 154 1 1
    NRG1 INSR 0 0 213 224 1 1
    NRG1 GNRH1 0 0 160 159 1 1
    NRG1 RHOA 0 600 222 688 1 1
    NRG1 AR 0 0 120 195 1 1
    NRG1 KCNH2 0 0 193 224 1 1
    NRG1 CSF2RA 0 0 141 164 1 1
    NRG1 FXYD6 0 0 150 157 1 1
    NRG1 SFTPB 0 0 135 156 1 1
    NRG1 SLC32A1 0 0 194 215 1 1
    NRG1 PTPRO 0 0 112 171 1 1
    NRG1 RHBDF2 0 0 0 194 1 1
    NRG1 CEBPE 0 0 0 292 1 1
    NRG1 FOXD3 0 0 218 218 1 1
    NRG1 ROBO1 0 0 193 243 1 1
    NRG1 NOP56 0 0 46 189 1 1
    NRG1 OCA2 0 0 72 185 1 1
    NRG1 SEMA4B 0 0 288 288 1 1
    NRG1 SOX9 0 0 218 218 1 1
    NRG1 NEUROG1 0 0 181 192 1 1
    NRG1 PTPRC 0 0 108 190 1 1
    NRG1 BCR 0 0 183 183 1 1
    NRG1 ABCA13 0 0 277 278 1 1
    NRG1 ESR2 0 0 864 864 1 1
    NRG1 BLOC1S5 0 0 166 165 1 1
    NRG1 SEMA4A 0 0 270 270 1 1
    NRG1 IGFBP2 0 0 210 215 1 1
    NRG1 PSEN1 0 0 357 357 1 2
    NRG1 HIATL1 0 0 150 157 1 1
    NRG1 GEMIN4 0 0 46 161 1 1
    NRG1 SOX2 0 0 294 294 1 1
    NRG1 NEUROD1 0 0 150 185 1 1
    NRG1 SH3TC2 0 0 271 285 1 1
    NRG1 BACE2 0 0 357 384 1 1
    NRG1 HSP90AA1 0 900 216 927 1 2
    NRG1 ZNF804A 0 0 595 595 1 1
    NRG1 SARAF 0 0 181 181 1 1
    NRG1 MMP9 0 0 388 401 1 1
    NRG1 B2M 0 0 123 150 1 1
    NRG1 MAPK3 0 900 458 947 1 2
    NRG1 ROS1 0 0 470 480 1 1
    NRG1 THY1 0 0 212 253 1 1
    NRG1 ANGPT1 0 0 231 235 1 1
    NRG1 FGF1 0 0 408 460 1 1
    NRG1 STUB1 0 0 90 164 1 2
    NRG1 GAS6 0 0 180 218 1 1
    NRG1 INS 0 0 335 376 1 1
    NRG1 ACTB 0 0 373 401 1 1
    NRG1 NEFH 0 0 124 196 1 1
    NRG1 ZNF185 0 0 59 179 1 1
    NRG1 STAT5B 0 900 119 909 1 1
    NRG1 TSC2 0 0 156 155 1 2
    NRG1 TGFB1 0 0 181 213 1 1
    NRG1 TIAM1 0 0 125 157 1 1
    NRG1 SBF2 0 0 194 209 1 1
    NRG1 CITED4 0 0 288 332 1 1
    NRG1 APLP2 0 0 369 373 1 1
    NRG1 CDKN1B 0 0 147 200 1 2
    NRG1 PPBP 0 0 64 230 1 1
    NRG1 SLC18A1 0 0 160 159 1 1
    NRG1 DCX 0 0 184 183 1 1
    NRG1 HMOX1 128 0 76 202 1 2
    NRG1 SLC17A7 0 0 289 288 1 1
    NRG1 MFAP3L 0 0 90 183 1 1
    NRG1 NTN1 0 0 289 288 1 1
    NRG1 KDR 0 0 242 275 1 2
    NRG1 MITF 0 0 155 154 1 1
    NRG1 HAS2 0 0 134 167 1 1
    NRG1 NFATC2 0 0 350 349 1 1
    NRG1 YY1 0 0 146 169 1 1
    NRG1 SEMA3F 0 0 321 321 1 1
    NRG1 A1BG 0 0 140 155 1 1
    NRG1 ELK4 0 0 113 174 1 1
    NRG1 ADAM22 0 0 218 275 1 1
    NRG1 CADM1 0 0 182 189 1 1
    NRG1 DAO 0 0 556 556 1 1
    NRG1 FLT1 0 0 144 205 1 1
    NRG1 DIXDC1 0 0 171 172 1 1
    NRG1 ROBO2 0 0 184 235 1 1
    NRG1 SEMA4F 0 0 287 286 1 1
    NRG1 PLSCR1 0 0 327 327 1 1
    NRG1 LPAR1 0 0 146 187 1 1
    NRG1 LGALS3 0 0 167 167 1 1
    NRG1 CAMK2D 0 500 42 500 1 1
    NRG1 HTR2A 0 0 451 451 1 1
    NRG1 GAD1 0 0 520 529 1 1
    NRG1 NAT1 0 0 330 330 1 1
    NRG1 RTN3 0 0 310 309 1 1
    NRG1 PTPRM 0 0 86 175 1 1
    NRG1 EIF2AK3 0 0 193 193 1 2
    NRG1 HNF4A 0 0 157 156 1 1
    NRG1 LRRC7 0 500 0 512 1 1
    NRG1 COMT 0 0 681 681 1 1
    NRG1 APOE 0 0 290 290 1 1
    NRG1 GFM1 0 0 413 412 1 1
    NRG1 KIF5B 0 0 193 193 1 1
    NRG1 TMEM164 195 0 0 195 1 1
    NRG1 RHBDF1 0 0 0 194 1 1
    NRG1 OXT 0 0 150 173 1 1
    NRG1 FOXO3 0 0 137 174 1 2
    NRG1 CHRNA2 0 0 325 330 1 1
    NRG1 ITGA6 0 0 150 303 1 1
    NRG1 EEA1 0 0 85 251 1 1
    NRG1 LSR 217 0 54 227 1 1
    NRG1 CDC42 0 0 261 302 1 1
    NRG1 CLDN19 0 0 67 164 1 1
    NRG1 LRP8 0 0 153 283 1 1
    NRG1 SRC 0 500 394 708 1 1
    NRG1 ADAM12 0 0 96 152 1 1
    NRG1 DKK1 0 0 193 224 1 1
    NRG1 SYNGAP1 0 0 150 160 1 1
    NRG1 ATP6V1A 0 0 0 260 1 1
    NRG1 TPM3 0 0 143 163 1 1
    NRG1 VLDLR 0 0 134 266 1 1
    NRG1 TGFBI 0 0 75 213 1 1
    NRG1 PDE4B 0 0 412 412 1 1
    NRG1 SLIT3 0 0 249 262 1 1
    NRG1 YES1 0 900 45 904 1 1
    NRG1 VEGFB 0 0 134 153 1 1
    NRG1 SLC25A23 271 0 0 271 1 1
    NRG1 TH 0 0 272 284 1 1
    NRG1 ECE1 0 0 392 392 1 1
    NRG1 NGF 0 0 507 598 1 1
    NRG1 CD34 0 0 134 156 1 1
    NRG1 ERBB2 282 900 989 999 1 2
    NRG1 GJA5 0 0 272 272 1 1
    NRG1 CADM2 0 0 142 195 1 1
    NRG1 FBXO2 0 0 62 350 1 1
    NRG1 PNOC 0 0 433 433 1 1
    NRG1 GRM5 0 0 216 216 1 1
    NRG1 NFATC4 0 0 538 538 1 1
    NRG1 DHX35 0 0 162 161 1 1
    NRG1 ST6GAL1 0 0 235 244 1 1
    NRG1 MAG 0 0 375 418 1 1
    NRG1 ARL13A 0 0 73 152 1 1
    NRG1 GJA1 0 0 243 269 1 1
    NRG1 CCK 0 0 168 199 1 1
    NRG1 ID2 0 0 180 249 1 1
    NRG1 FOXE1 0 0 319 319 1 1
    NRG1 PCDH17 0 0 67 247 1 1
    NRG1 EDNRB 0 0 307 307 1 1
    NRG1 CST6 0 0 0 288 1 1
    NRG1 RTN4 0 0 299 309 1 1
    NRG1 FGF3 0 0 123 217 1 1
    NRG1 DRD4 0 0 370 370 1 1
    NRG1 ITPK1 0 0 210 217 1 1
    NRG1 ANK3 0 0 371 371 1 1
    NRG1 AXL 0 0 271 310 1 1
    NRG1 EYA2 0 0 83 178 1 1
    NRG1 HSP90AB1 0 0 66 235 1 2
    NRG1 PRX 0 0 391 484 1 1
    NRG1 FBXO15 0 0 134 157 1 1
    NRG1 GRIK4 0 0 187 187 1 1
    NRG1 EPGN 0 0 517 550 1 1
    NRG1 SCN5A 0 0 108 151 1 1
    NRG1 B3GNT2 239 0 0 238 1 1
    NRG1 KLF4 0 0 154 153 1 1
    NRG1 CD247 0 0 386 386 1 1
    NRG1 TDRD5 0 0 46 290 1 1
    NRG1 FGFR1 0 0 426 443 1 1
    NRG1 VIP 0 0 167 167 1 1
    NRG1 NTRK2 0 0 403 403 1 1
    NRG1 PARL 0 0 0 194 1 1
    NRG1 DLG1 0 500 218 592 1 1
    NRG1 VMP1 0 0 71 268 1 2
    NRG1 CELSR3 0 0 150 183 1 1
    NRG1 SEMA6D 0 0 285 284 1 1
    NRG1 DISC1 0 0 804 807 1 1
    NRG1 GRIK1 0 0 181 181 1 1
    NRG1 TBRG4 0 0 47 162 1 1
    NRG1 MKI67 0 0 82 218 1 1
    NRG1 PREX2 0 0 155 156 1 1
    NRG1 CACNA2D1 0 0 0 411 1 1
    NRG1 AKT1 0 0 615 639 1 2
    NRG1 TGFB2 0 0 181 228 1 1
    NRG1 LHX3 0 0 134 159 1 1
    NRG1 SLIT2 0 0 193 230 1 1
    NRG1 PPARG 0 0 180 203 1 1
    NRG1 UBE3A 0 0 457 457 1 1
    NRG1 SEMA7A 0 0 271 271 1 1
    NRG1 MAK16 0 0 134 164 1 1
    NRG1 SYN2 0 0 258 274 1 1
    NRG1 TMSB4X 0 0 128 194 1 1
    NRG1 GPC1 0 900 73 905 1 1
    NRG1 KIAA1279 0 0 392 392 1 1
    NRG1 PEBP1 0 0 175 175 1 1
    NRG1 APH1B 0 0 448 448 1 1
    NRG1 VCL 0 0 67 166 1 1
    NRG1 PDGFC 0 0 193 228 1 1
    NRG1 PAX3 0 0 249 248 1 1
    NRG1 ITCH 0 900 91 905 1 1
    NRG1 GRM4 0 0 172 171 1 1
    NRG1 FMR1 0 0 253 252 1 1
    NRG1 RBFOX3 0 0 294 298 1 1
    NRG1 IKZF4 213 0 306 430 1 1
    NRG1 ABCA2 0 0 296 300 1 1
    NRG1 PMP22 0 0 323 353 1 1
    NRG1 SEMA4D 0 0 293 293 1 1
    NRG1 SRR 0 0 235 235 1 1
    NRG1 PAFAH1B1 0 0 233 232 1 1
    NRG1 TNF 0 0 284 303 1 1
    NRG1 SNAP25 0 0 294 294 1 1
    NRG1 GABRG2 0 650 112 708 1 1
    NRG1 PLCB1 0 0 138 192 1 1
    NRG1 NR4A2 0 0 205 205 1 1
    NRG1 PDLIM5 0 0 181 181 1 1
    NRG1 MMP3 0 0 135 180 1 1
    NRG1 KRT14 0 0 142 165 1 1
    NRG1 CD44 0 0 249 255 1 1
    NRG1 MEF2C 0 0 227 274 1 1
    NRG1 ANKRD1 0 0 143 159 1 1
    NRG1 BDNF 0 0 621 644 1 2
    NRG1 CHRNA1 0 0 170 186 1 1
    NRG1 NRN1 0 0 194 194 1 1
    NRG1 CDH5 0 0 118 152 1 1
    NRG1 CDK5R2 0 0 63 172 1 1
    NRG1 ATF3 0 0 156 163 1 1
    NRG1 EPHB4 0 0 143 275 1 1
    NRG1 CNR1 0 0 248 248 1 1
    NRG1 RHBDL1 0 0 0 213 1 1
    NRG1 EFNA3 0 0 124 220 1 1
    NRG1 RNF41 0 900 241 920 1 1
    NRG1 THBS2 0 0 150 214 1 1
    NRG1 HEATR2 226 0 0 225 1 1
    NRG1 MAPK1 0 900 161 917 1 2
    NRG1 IGF1 0 0 644 666 1 1
    NRG1 ITGA3 0 0 93 171 1 1
    NRG1 CSF1R 0 0 116 165 1 1
    NRG1 TBX18 0 0 150 214 1 1
    NRG1 SOS1 0 900 47 900 1 1
    NRG1 GNG13 0 0 293 293 1 1
    NRG1 PGAP1 234 0 0 234 1 1
    NRG1 TNNT2 0 0 267 311 1 1
    NRG1 PTCH1 0 0 90 156 1 1
    NRG1 RAPSN 0 0 214 214 1 1
    NRG1 IL1R2 0 0 168 223 1 1
    NRG1 CACNG2 0 0 258 258 1 1
    NRG1 CCND2 0 0 202 210 1 1
    NRG1 SNCG 0 0 67 442 1 1
    NRG1 FNBP1L 0 0 126 214 1 1
    NRG1 TYMP 0 0 141 160 1 1
    NRG1 FGF2 0 0 502 558 1 1
    NRG1 NAT9 0 0 193 459 1 1
    NRG1 FGF5 0 0 113 174 1 1
    NRG1 PTPRE 0 0 0 160 1 1
    NRG1 MTHFR 0 0 306 306 1 1
    NRG1 NOS3 0 0 232 231 1 1
    NRG1 SEMA3A 0 0 407 428 1 1
    NRG1 EPHA1 0 0 202 238 1 1
    NRG1 MEIS1 0 0 202 223 1 1
    NRG1 SREBF2 213 0 73 239 1 1
    NRG1 FSHR 0 0 82 211 1 1
    NRG1 CCND1 0 0 261 307 1 1
    NRG1 CPLX1 0 0 193 193 1 1
    NRG1 PGR 0 0 190 246 1 1
    NRG1 APOL2 0 0 242 241 1 1
    NRG1 NCOR1 0 0 359 359 1 1
    NRG1 VASH1 0 0 61 159 1 1
    NRG1 SERPINE1 0 0 150 181 1 1
    NRG1 RPS6KB1 0 0 203 203 1 2
    NRG1 OLIG2 0 0 520 526 1 1
    NRG1 HEY1 0 0 166 173 1 1
    NRG1 YWHAQ 0 0 74 153 1 1
    NRG1 REM1 0 0 0 320 1 1
    NRG1 KCNA1 0 0 162 179 1 1
    NRG1 EPHB1 0 0 165 186 1 1
    NRG1 IRS1 0 0 119 174 1 1
    NRG1 SYN3 0 0 181 198 1 1
    NRG1 CBL 0 0 139 171 1 1
    NRG1 DAOA 0 0 708 708 1 1
    NRG1 LOX 0 0 190 219 1 1
    NRG1 DRD1 0 0 264 343 1 1
    NRG1 EGR2 0 0 507 520 1 1
    NRG1 PROK2 0 0 150 174 1 1
    NRG1 CNTNAP3B 0 0 0 160 1 1
    NRG1 NTRK1 0 0 618 618 1 1
    NRG1 ADRA1D 0 0 93 160 1 1
    NRG1 MAGI2 0 0 206 206 1 1
    NRG1 ENSG00000264813 0 0 219 219 1 1
    NRG1 FSTL1 0 0 182 233 1 1
    NRG1 HGF 0 0 386 415 1 1
    NRG1 SASH1 0 0 181 188 1 1
    NRG1 NUMBL 0 0 166 165 1 1
    NRG1 FBXL4 0 0 61 258 1 1
    NRG1 MMP28 0 0 140 166 1 1
    NRG1 POU5F1 0 0 177 207 1 1
    NRG1 MEMO1 0 600 0 600 1 1
    NRG1 GRIA1 0 0 325 325 1 1
    NRG1 PTGDS 0 0 203 203 1 1
    NRG1 PECAM1 0 0 235 235 1 1
    NRG1 UBB 0 600 0 608 1 1
    NRG1 NKX2-5 0 0 344 396 1 1
    NRG1 PTK2B 0 0 188 195 1 1
    NRG1 SEMA4G 0 0 271 271 1 1
    NRG1 ATP2A2 0 0 134 180 1 1
    NRG1 GRID1 0 0 202 202 1 2
    NRG1 EFNA1 0 0 142 162 1 1
    NRG1 PHOX2B 0 0 335 335 1 1
    NRG1 LDLR 0 0 143 166 1 1
    NRG1 NDEL1 0 0 267 317 1 1
    NRG1 FGF16 0 0 140 266 1 1
    NRG1 MDK 0 0 181 251 1 1
    NRG1 SEMA5B 0 0 294 294 1 1
    NRG1 ADCY2 0 0 108 166 1 1
    NRG1 NFASC 0 0 178 220 1 1
    NRG1 CCKBR 0 0 42 412 1 1
    NRG1 GABRQ 0 650 57 664 1 1
    NRG1 PPP1R9A 0 0 489 489 1 1
    NRG1 PTPRG 0 0 81 194 1 1
    NRG1 BMP4 0 0 266 275 1 1
    NRG1 TCF4 0 0 167 167 1 1
    NRG1 LEP 0 0 155 154 1 1
    NRG1 KIT 0 0 283 310 1 1
    NRG1 ENSG00000258947 0 0 165 207 1 1
    NRG1 TIMP3 0 0 150 228 1 1
    NRG1 MAPK14 0 0 166 252 1 1
    NRG1 CFL1 0 0 427 427 1 1
    NRG1 ARTN 0 0 360 360 1 1
    NRG1 CNTN2 0 0 273 324 1 1
    NRG1 UBA52 0 600 0 600 1 1
    NRG1 NGFR 0 0 325 367 1 1
    NRG1 MAPK7 0 0 95 171 1 1
    NRG1 CHL1 0 0 373 386 1 1
    NRG1 NFIA 0 0 158 157 1 1
    NRG1 VEGFA 0 0 391 390 1 1
    NRG1 YARS 0 0 0 191 1 1
    NRG1 PTEN 0 0 382 398 1 2
    NRG1 MBP 0 0 466 506 1 1
    NRG1 NTRK3 0 0 391 390 1 1
    NRG1 RHBDL2 0 0 0 206 1 1
    NRG1 NFATC1 0 0 164 163 1 1
    NRG1 DRD3 0 0 339 339 1 2
    NRG1 FOSB 0 0 112 205 1 1
    NRG1 EGLN2 0 0 279 279 1 1
    NRG1 DMD 0 0 134 193 1 1
    NRG1 TAC1 0 0 161 177 1 1
    NRG1 ACTG1 0 0 140 158 1 1
    NRG1 DLG4 0 900 644 962 1 1
    NRG1 MBIP 0 0 325 325 1 1
    NRG1 GDF15 0 0 240 303 1 1
    NRG1 CPLX2 0 0 254 254 1 1
    NRG1 IKZF1 0 0 456 456 1 1
    NRG1 EFNB2 0 0 332 359 1 1
    NRG1 DBH 0 0 107 162 1 1
    NRG1 SNAI1 0 0 171 198 1 1
    NRG1 IL10 0 0 181 181 1 1
    NRG1 PPP3R1 0 0 539 539 1 1
    NRG1 SEMA6B 0 0 276 276 1 1
    NRG1 GFRA1 0 0 284 300 1 1
    NRG1 GFAP 0 0 391 390 1 2
    NRG1 RBPJ 0 0 233 320 1 1
    NRG1 ITGB4 0 0 152 184 1 1
    NRG1 LPHN1 208 0 0 227 1 1
    NRG1 ATP7B 189 0 0 189 1 1
    NRG1 IGF2 0 0 235 247 1 1
    NRG1 TEAD1 0 0 196 216 1 1
    NRG1 NTF4 0 0 279 288 1 1
    NRG1 DRD5 0 0 87 186 1 1
    NRG1 GAD2 0 0 260 260 1 1
    NRG1 SCN2B 0 0 308 325 1 1
    NRG1 KCNA2 0 0 113 168 1 1
    NRG1 SHC1 0 900 252 924 1 1
    NRG1 SFRP1 0 0 156 178 1 1
    NRG1 ATM 0 0 145 163 1 1
    NRG1 SOX10 0 0 556 564 1 1
    NRG1 NRGN 0 0 364 364 1 1
    NRG1 NRXN1 0 0 406 406 1 1
    NRG1 ARSJ 0 0 0 165 1 1
    NRG1 RET 0 0 624 635 1 1
    NRG1 FGF12 0 0 120 212 1 1
    NRG1 SEMA3E 0 0 284 284 1 1
    NRG1 ENG 0 0 151 150 1 1
    NRG1 DIRC3 0 0 454 454 1 1
    NRG1 PRKCA 0 0 206 206 1 1
    NRG1 RPS6KA1 0 0 144 175 1 1
    NRG1 LATS1 0 0 155 174 1 1
    NRG1 NCAM1 0 0 267 267 1 1
    NRG1 DLX1 0 0 172 198 1 1
    NRG1 CAMK2A 0 500 141 555 1 2
    NRG1 STX7 0 0 149 181 1 2
    NRG1 ATP6AP1 0 0 47 220 1 1
    NRG1 RARA 0 0 66 162 1 1
    NRG1 MUSK 0 0 342 354 1 1
    NRG1 TBP 0 0 142 164 1 1
    NRG1 FN1 0 0 320 359 1 1
    NRG1 AKT3 0 0 212 250 1 1
    NRG1 CTNNA2 0 0 247 247 1 1
    NRG1 NKX2-1 0 0 372 385 1 1
    NRG1 GALC 0 0 180 239 1 1
    NRG1 S100A4 417 0 95 453 1 1
    NRG1 TERT 0 0 167 167 1 1
    NRG1 CLSTN2 0 0 134 153 1 1
    NRG1 MGLL 0 0 124 152 1 1
    NRG1 HSPB1 0 0 122 194 1 1
    NRG1 ADAM19 213 0 321 442 1 1
    NRG1 NETO1 0 0 170 169 1 1
    NRG1 WDR43 0 0 56 223 1 1
    NRG1 UBC 0 600 95 630 1 1
    NRG1 CNTNAP5 0 0 145 392 1 1
    NRG1 SERPINB5 0 0 156 185 1 1
    NRG1 HAND2 0 0 252 259 1 1
    NRG1 ADAM17 0 900 574 958 1 1
    NRG1 NRTN 0 0 324 323 1 1
    NRG1 PCDH11X 0 0 163 181 1 1
    NRG1 DSEL 0 0 81 260 1 1
    NRG1 CAMK2G 0 500 57 508 1 1
    NRG1 PTPRA 0 0 124 357 1 1
    NRG1 WNT3A 0 0 218 218 1 1
    NRG1 CNTNAP2 0 0 203 302 1 1
    NRG1 CRH 0 0 134 152 1 1
    NRG1 ERCC6 0 0 0 156 1 1
    NRG1 LGR5 0 0 122 202 1 1
    NRG1 ITGB3 0 0 134 203 1 1
    NRG1 GRIN1 0 500 261 681 1 1
    NRG1 TNIK 0 0 153 319 1 1
    NRG1 SYP 0 0 247 246 1 1
    NRG1 GRM2 0 0 233 232 1 1
    NRG1 YAP1 0 0 203 240 1 1
    NRG1 TP63 0 0 160 166 1 2
    NRG1 SEMA6C 0 0 287 286 1 1
    NRG1 PTPRZ1 0 0 242 292 1 1
    NRG1 SLC6A3 0 0 332 332 1 1
    NRG1 CTF1 0 0 155 172 1 1
    NRG1 CST7 0 0 73 239 1 1
    NRG1 SFXN3 215 0 0 215 1 1
    NRG1 TMEM132B 0 0 0 248 1 1
    NRG1 PRL 0 0 218 218 1 1
    NRG1 NPAS3 0 0 271 271 1 1
    NRG1 ST8SIA2 0 0 140 159 1 1
    NRG1 KIF13B 0 0 577 577 1 1
    NRG1 SMARCA4 0 0 179 196 1 1
    NRG1 MYOCD 0 0 134 180 1 1
    NRG1 NRD1 0 0 261 307 1 1
    NRG1 BACE1 0 0 683 717 1 1
    NRG1 PCNXL2 0 0 208 208 1 1
    NRG1 SEZ6 0 0 108 260 1 1
    NRG1 HOMER1 0 0 171 171 1 1
    NRG1 PDE10A 0 0 194 195 1 1
    NRG1 ESR1 0 0 462 462 1 1
    NRG1 AGAP1 0 0 182 181 1 1
    NRG1 SLC45A2 0 0 104 205 1 1
    NRG1 PIK3CB 0 900 134 910 1 1
    NRG1 APH1A 0 0 299 299 1 1
    NRG1 PTGER3 0 0 268 268 1 1
    NRG1 GRIN2B 0 900 500 947 1 1
    NRG1 ELAVL4 0 0 142 170 1 1
    NRG1 CCDC88A 0 0 162 161 1 1
    NRG1 MET 0 0 293 323 1 1
    NRG1 MAPT 0 0 180 179 1 2
    NRG1 ABCB1 0 0 150 203 1 1
    NRG1 THBS1 0 0 181 245 1 1
    NRG1 CAMK2B 0 500 61 510 1 1
    NRG1 SMARCD3 0 0 138 157 1 1
    NRG1 SHC4 0 0 181 182 1 1
    NRG1 PSENEN 0 0 271 271 1 1
    NRG1 FZD3 0 0 181 181 1 1
    NRG1 STT3A 0 0 184 183 1 1
    NRG1 SFRP2 0 0 184 246 1 1
    NRG1 RUFY2 0 0 180 179 1 1
    NRG1 SEMA5A 0 0 286 286 1 1
    NRG1 RHOBTB3 217 0 61 262 1 1
    NRG1 CHRM4 0 0 308 307 1 1
    NRG1 SERPINB4 0 0 155 154 1 1
    NRG1 LPCAT2 0 0 153 186 1 1
    NRG1 DLX5 0 0 184 201 1 1
    NRG1 CDK5R1 0 0 95 177 1 1
    NRG1 SCN8A 0 0 107 181 1 1
    NRG1 PGF 0 0 143 162 1 1
    NRG1 GLIS3 0 0 150 181 1 1
    NRG1 CSPG4 0 0 146 178 1 1
    NRG1 GRID2 0 0 209 209 1 2
    NRG1 RXRB 0 0 74 215 1 1
    NRG1 DGCR2 0 0 155 154 1 1
    NRG1 ENSG00000251246 0 0 87 187 1 1
    NRG1 GABBR1 0 0 165 165 1 1
    NRG1 CNP 0 0 324 324 1 1
    NRG1 SLC48A1 0 0 81 279 1 1
    NRG1 NAB2 0 0 120 154 1 1
    NRG1 ANGPTL4 0 0 158 157 1 1
    NRG1 GAB1 0 500 211 591 1 1
    NRG1 STAT5A 0 900 171 915 1 1
    NRG1 PTPN11 0 900 261 929 1 1
    NRG1 VSTM5 0 0 218 218 1 1
    NRG1 ZNF470 0 0 247 246 1 1
    NRG1 SV2A 0 0 113 174 1 1
    NRG1 COL12A1 0 0 67 160 1 1
    NRG1 FOS 0 0 270 276 1 1
    NRG1 TWIST1 0 0 140 163 1 1
    NRG1 HEY2 0 0 217 217 1 1
    NRG1 APLP1 0 0 390 391 1 1
    NRG1 PTK6 0 600 108 627 1 1
    NRG1 SPP2 0 0 0 292 1 1
    NRG1 MATK 0 600 0 600 1 1
    NRG1 DTNBP1 0 0 823 823 1 1
    NRG1 FOXO1 0 0 167 167 1 2
    NRG1 KRAS 0 900 391 944 1 1
    NRG1 LGI1 0 0 139 171 1 1
    NRG1 SLC35B2 220 0 48 225 1 1
    NRG1 NRAS 169 900 141 926 1 1
    NRG1 PDE7B 0 0 95 189 1 1
    NRG1 PDYN 0 0 134 175 1 1
    NRG1 FOXP2 0 0 209 209 1 1
    NRG1 ASCL1 0 0 284 284 1 1
    NRG1 WNT2 0 0 170 208 1 1
    NRG1 NTF3 0 0 468 498 1 1
    NRG1 QSOX2 0 0 105 201 1 1
    NRG1 CHRND 0 0 134 239 1 1
    NRG1 EPHB2 0 0 217 322 1 2
    NRG1 ADM 0 0 145 164 1 1
    NRG1 RPS27A 0 600 0 600 1 1
    NRG1 EPHA3 0 0 150 172 1 1
    NRG1 SST 0 0 281 310 1 1
    NRG1 CDKN2A 0 0 217 217 1 2
    NRG1 PTPN12 0 900 0 914 1 1
    NRG1 CXCL16 0 0 82 178 1 1
    NRG1 GRIN3A 0 0 249 269 1 1
    NRG1 GSK3B 0 0 207 287 1 2
    NRG1 S100B 0 0 325 329 1 1
    NRG1 FAT4 0 0 96 167 1 1
    NRG1 FGF8 0 0 189 244 1 1
    NRG1 LHX6 0 0 283 297 1 1
    NRG1 PRODH2 0 0 162 161 1 1
    NRG1 PROKR2 0 0 150 187 1 1
    NRG1 FGF11 0 0 66 164 1 1
    NRG1 PHC3 0 0 193 193 1 1
    NRG1 CSF1 0 0 142 174 1 1
    NRG1 HDAC1 0 0 150 181 1 2
    NRG1 GAB3 0 0 124 156 1 1
    NRG1 ENSG00000258838 0 0 0 156 1 1
    NRG1 PIK3CD 0 0 181 186 1 1
    NRG1 GPR126 0 0 281 304 1 1
    NRG1 CEBPB 0 0 156 170 1 1
    NRG1 FGF9 0 0 181 263 1 1
    NRG1 LIMK1 270 0 490 612 1 1
    NRG1 CNTNAP3 204 0 0 303 1 1
    NRG1 CCKAR 0 0 103 450 1 1
    NRG1 ATAT1 0 0 50 567 1 1
    NRG1 CASP3 0 0 282 282 1 2
    NRG1 ERBB3 898 900 989 999 1 1
    NRG1 PTGS2 0 0 155 180 1 1
    NRG1 FGF19 0 0 74 171 1 1
    NRG1 EPHA5 0 0 154 235 1 1
    NRG1 SLC25A16 222 0 46 226 1 1
    NRG1 CXCL1 0 0 150 202 1 1
    NRG1 HYPK 0 0 57 158 1 1
    NRG1 CARD16 0 0 0 345 1 1
    NRG1 GABRG3 0 650 60 664 1 1
    NRG1 GABRB3 0 650 71 682 1 1
    NRG1 VEGFC 0 0 181 230 1 1
    NRG1 GGA3 0 0 146 164 1 1
    NRG1 DLG3 0 500 164 594 1 1
    NRG1 AAK1 0 0 113 174 1 1
    NRG1 CACNA2D3 0 0 0 161 1 1
    NRG1 CNTN5 0 0 134 172 1 1
    NRG1 GRM1 0 0 195 195 1 1
    NRG1 QKI 0 0 194 194 1 1
    NRG1 PTPN5 0 0 158 214 1 1
    NRG1 NOLC1 0 0 46 172 1 1
    NRG1 ACE 0 0 218 218 1 1
    NRG1 NOTCH2 0 0 160 177 1 1
    NRG1 ANG 0 0 144 151 1 1
    NRG1 CYP46A1 0 0 306 306 1 1
    NRG1 PPM1B 0 0 411 411 1 1
    NRG1 FGF22 0 0 61 159 1 1
    NRG1 SLC1A1 0 0 183 183 1 1
    NRG1 NDE1 0 0 156 208 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0043125 Molecular Function ErbB-3 class receptor binding enables IDA
    GO:0043125 Molecular Function ErbB-3 class receptor binding enables IPI
    GO:0045499 Molecular Function chemorepellent activity enables IBA
    GO:0005125 Molecular Function cytokine activity enables TAS
    GO:0008083 Molecular Function growth factor activity enables IDA
    GO:0008083 Molecular Function growth factor activity enables NAS
    GO:0005178 Molecular Function integrin binding enables IDA
    GO:0016151 Molecular Function nickel cation binding enables IPI
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0030296 Molecular Function protein tyrosine kinase activator activity enables IBA
    GO:0030296 Molecular Function protein tyrosine kinase activator activity enables IDA
    GO:0048018 Molecular Function receptor ligand activity enables IDA
    GO:0030971 Molecular Function receptor tyrosine kinase binding enables NAS
    GO:0005102 Molecular Function signaling receptor binding enables IPI
    GO:0003712 Molecular Function transcription coregulator activity enables IDA
    GO:0030297 Molecular Function transmembrane receptor protein tyrosine kinase activator activity enables IC
    GO:0030297 Molecular Function transmembrane receptor protein tyrosine kinase activator activity enables NAS
    GO:0008270 Molecular Function zinc ion binding enables IPI
    GO:0038127 Biological Process ERBB signaling pathway involved_in IDA
    GO:0038127 Biological Process ERBB signaling pathway involved_in IMP
    GO:0038133 Biological Process ERBB2-ERBB3 signaling pathway involved_in IBA
    GO:0038133 Biological Process ERBB2-ERBB3 signaling pathway involved_in IDA
    GO:0038135 Biological Process ERBB2-ERBB4 signaling pathway involved_in IDA
    GO:0038129 Biological Process ERBB3 signaling pathway involved_in IDA
    GO:0038130 Biological Process ERBB4 signaling pathway involved_in IBA
    GO:0038130 Biological Process ERBB4 signaling pathway involved_in IDA
    GO:0038138 Biological Process ERBB4-ERBB4 signaling pathway involved_in IDA
    GO:0032148 Biological Process activation of protein kinase B activity involved_in IMP
    GO:0007171 Biological Process activation of transmembrane receptor protein tyrosine kinase activity involved_in IDA
    GO:0007420 Biological Process brain development involved_in IBA
    GO:0055007 Biological Process cardiac muscle cell differentiation involved_in ISS
    GO:0060379 Biological Process cardiac muscle cell myoblast differentiation involved_in IDA
    GO:0007154 Biological Process cell communication involved_in TAS
    GO:0030154 Biological Process cell differentiation involved_in IBA
    GO:0008283 Biological Process cell population proliferation involved_in IDA
    GO:0007169 Biological Process cell surface receptor protein tyrosine kinase signaling pathway involved_in IDA
    GO:0060956 Biological Process endocardial cell differentiation involved_in IDA
    GO:0035556 Biological Process intracellular signal transduction involved_in IBA
    GO:0030879 Biological Process mammary gland development involved_in TAS
    GO:0050919 Biological Process negative chemotaxis involved_in IEA
    GO:0045892 Biological Process negative regulation of DNA-templated transcription acts_upstream_of_or_within IDA
    GO:0010667 Biological Process negative regulation of cardiac muscle cell apoptotic process involved_in IDA
    GO:2001240 Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand involved_in IDA
    GO:0051048 Biological Process negative regulation of secretion involved_in IDA
    GO:0007399 Biological Process nervous system development involved_in TAS
    GO:0014032 Biological Process neural crest cell development involved_in TAS
    GO:0007422 Biological Process peripheral nervous system development involved_in IBA
    GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IMP
    GO:0060045 Biological Process positive regulation of cardiac muscle cell proliferation involved_in IDA
    GO:0045785 Biological Process positive regulation of cell adhesion involved_in IDA
    GO:0030307 Biological Process positive regulation of cell growth involved_in IDA
    GO:0008284 Biological Process positive regulation of cell population proliferation involved_in IMP
    GO:1900086 Biological Process positive regulation of peptidyl-tyrosine autophosphorylation involved_in IDA
    GO:0031334 Biological Process positive regulation of protein-containing complex assembly involved_in IDA
    GO:0031334 Biological Process positive regulation of protein-containing complex assembly involved_in TAS
    GO:0051155 Biological Process positive regulation of striated muscle cell differentiation involved_in ISS
    GO:0099149 Biological Process regulation of postsynaptic neurotransmitter receptor internalization involved_in IDA
    GO:0099149 Biological Process regulation of postsynaptic neurotransmitter receptor internalization involved_in IMP
    GO:0055012 Biological Process ventricular cardiac muscle cell differentiation involved_in IDA
    GO:0003222 Biological Process ventricular trabecula myocardium morphogenesis involved_in IDA
    GO:0042060 Biological Process wound healing involved_in IDA
    GO:0042060 Biological Process wound healing involved_in TAS
    GO:0016324 Cellular Component apical plasma membrane located_in IDA
    GO:0005576 Cellular Component extracellular region located_in NAS
    GO:0005576 Cellular Component extracellular region located_in TAS
    GO:0005615 Cellular Component extracellular space is_active_in IBA
    GO:0005615 Cellular Component extracellular space is_active_in IDA
    GO:0005615 Cellular Component extracellular space located_in IDA
    GO:0098978 Cellular Component glutamatergic synapse is_active_in IDA
    GO:0098978 Cellular Component glutamatergic synapse is_active_in IMP
    GO:0016020 Cellular Component membrane located_in NAS
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in IEA
    Pathways
    Name DB ID
    Neurotransmitter receptors and postsynaptic signal transmission Reactome R-HSA-112314
    Transmission across Chemical Synapses Reactome R-HSA-112315
    Neuronal System Reactome R-HSA-112316
    Signaling by ERBB2 Reactome R-HSA-1227986
    Signaling by ERBB2 in Cancer Reactome R-HSA-1227990
    Signaling by ERBB4 Reactome R-HSA-1236394
    SHC1 events in ERBB2 signaling Reactome R-HSA-1250196
    PI3K events in ERBB4 signaling Reactome R-HSA-1250342
    SHC1 events in ERBB4 signaling Reactome R-HSA-1250347
    Nuclear signaling by ERBB4 Reactome R-HSA-1251985
    PIP3 activates AKT signaling Reactome R-HSA-1257604
    GRB7 events in ERBB2 signaling Reactome R-HSA-1306955
    Downregulation of ERBB2:ERBB3 signaling Reactome R-HSA-1358803
    Signal Transduction Reactome R-HSA-162582
    Disease Reactome R-HSA-1643685
    GRB2 events in ERBB2 signaling Reactome R-HSA-1963640
    PI3K events in ERBB2 signaling Reactome R-HSA-1963642
    Negative regulation of the PI3K/AKT network Reactome R-HSA-199418
    PI3K/AKT Signaling in Cancer Reactome R-HSA-2219528
    Constitutive Signaling by Aberrant PI3K in Cancer Reactome R-HSA-2219530
    Post NMDA receptor activation events Reactome R-HSA-438064
    Activation of NMDA receptors and postsynaptic events Reactome R-HSA-442755
    Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
    RAF/MAP kinase cascade Reactome R-HSA-5673001
    MAPK family signaling cascades Reactome R-HSA-5683057
    MAPK1/MAPK3 signaling Reactome R-HSA-5684996
    ERBB2 Regulates Cell Motility Reactome R-HSA-6785631
    PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Reactome R-HSA-6811558
    ERBB2 Activates PTK6 Signaling Reactome R-HSA-8847993
    Signaling by PTK6 Reactome R-HSA-8848021
    Downregulation of ERBB2 signaling Reactome R-HSA-8863795
    Intracellular signaling by second messengers Reactome R-HSA-9006925
    Signaling by Non-Receptor Tyrosine Kinases Reactome R-HSA-9006927
    Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
    Long-term potentiation Reactome R-HSA-9620244
    Signaling by ERBB2 KD Mutants Reactome R-HSA-9664565
    Signaling by ERBB2 TMD/JMD mutants Reactome R-HSA-9665686
    7q11.23 copy number variation syndrome (WP4932) WikiPathways WP4932_r118797
    EGFR tyrosine kinase inhibitor resistance (WP4806) WikiPathways WP4806_r123492
    Apoptosis-related network due to altered Notch3 in ovarian cancer (WP2864) WikiPathways WP2864_r108133
    Cardiac progenitor differentiation (WP2406) WikiPathways WP2406_r119249
    ErbB signaling pathway (WP673) WikiPathways WP673_r118930
    MicroRNAs in cardiomyocyte hypertrophy (WP1544) WikiPathways WP1544_r121713
    Nuclear receptors meta-pathway (WP2882) WikiPathways WP2882_r120815
    Neurogenesis regulation in the olfactory epithelium (WP5265) WikiPathways WP5265_r123524
    NRF2 pathway (WP2884) WikiPathways WP2884_r106658
    Cardiac hypertrophic response (WP2795) WikiPathways WP2795_r117670
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001159999 3 mRNA transcript variant HRG-beta1b NC_000008 Reference
    NM_001159995 3 mRNA transcript variant HRG-beta1c NC_000008 Reference
    NM_001322201 2 mRNA transcript variant fetal-a-IV-1 NC_000008 Reference
    NM_001160001 3 mRNA transcript variant HRG-beta1d NC_000008 Reference
    NM_001322202 2 mRNA transcript variant fetal-c-IV-2 NC_000008 Reference
    XM_011544512 3 mRNA transcript variant X1 NC_000008 Reference
    XM_017013367 2 mRNA transcript variant X2 NC_000008 Reference
    XM_017013371 3 mRNA transcript variant X4 NC_000008 Reference
    XM_017013372 3 mRNA transcript variant X5 NC_000008 Reference
    NM_013962 3 mRNA transcript variant GGF2 NC_000008 Reference
    NM_013960 5 mRNA transcript variant ndf43 NC_000008 Reference
    NM_013964 5 mRNA transcript variant HRG-alpha NC_000008 Reference
    NM_013956 5 mRNA transcript variant HRG-beta1 NC_000008 Reference
    NM_001160004 3 mRNA transcript variant ndf43b NC_000008 Reference
    NM_013957 5 mRNA transcript variant HRG-beta2 NC_000008 Reference
    XM_017013368 3 mRNA transcript variant X3 NC_000008 Reference
    NM_001160008 2 mRNA transcript variant HRG-beta2b NC_000008 Reference
    NM_013958 4 mRNA transcript variant HRG-beta3 NC_000008 Reference
    NM_001160005 2 mRNA transcript variant HRG-beta3b NC_000008 Reference
    NM_004495 4 mRNA transcript variant HRG-gamma NC_000008 Reference
    NM_001160002 2 mRNA transcript variant HRG-gamma2 NC_000008 Reference
    NM_001160007 2 mRNA transcript variant HRG-gamma3 NC_000008 Reference
    NM_001322206 2 mRNA transcript variant III-2 NC_000008 Reference
    NM_001322205 2 mRNA transcript variant NRG-III-beta1a NC_000008 Reference
    NM_001322207 2 mRNA transcript variant III-3 NC_000008 Reference
    NM_013959 4 mRNA transcript variant SMDF NC_000008 Reference
    NM_001159996 3 mRNA transcript variant ndf43c NC_000008 Reference
    NM_001322197 2 mRNA transcript variant VI-1 NC_000008 Reference