HSPB1

heat shock protein family B (small) member 1

General Information

Name	heat shock protein family B (small) member 1
Alias	heat shock protein beta-1 28 kDa heat shock protein epididymis secretory protein Li 102 estrogen-regulated 24 kDa protein heat shock 27 kDa protein heat shock 27kD protein 1 heat shock 27kDa protein 1 stress-responsive protein 27
Gene_family	Small heat shock proteins
organism	Homo sapiens
entrez_id	3315
location	7q11.23
transcript_count	1
exon_count	3

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Stringdb Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins

nextProt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).

Interactions

NCBI

Show entries

Search:


HSPB1	BioGRID	PRNP	GeneID	BioGRID	Affinity Capture-MS
HSPB1	BioGRID	MYC	GeneID	BioGRID	Affinity Capture-MS; Proximity Label-MS
HSPB1	BioGRID	CBL	GeneID	BioGRID	Affinity Capture-MS
HSPB1	BioGRID	EZH2	GeneID	BioGRID	Affinity Capture-MS
HSPB1	BioGRID	DDX24	GeneID	BioGRID	Affinity Capture-MS
HSPB1	BioGRID	S	GeneID	BioGRID	Affinity Capture-MS
HSPB1	BioGRID	MSH2	GeneID	BioGRID	Affinity Capture-Western
HSPB1	BioGRID	MAP1LC3B	GeneID	BioGRID	Proximity Label-MS
HSPB1	BioGRID	KBTBD4	GeneID	BioGRID	Proximity Label-MS
HSPB1	BioGRID	SRSF10	GeneID	BioGRID	Affinity Capture-MS

Showing 1 to 10 of 712 entries

StringDB

Show entries

Search:


HSPB1	MAPK15	0	95	194	1	1
HSPB1	BTN1A1	0	66	210	1	1
HSPB1	NME2	0	161	191	1	1
HSPB1	CYBB	0	180	179	1	2
HSPB1	VEGFC	0	162	213	1	1
HSPB1	TNFRSF10B	0	284	284	1	2
HSPB1	COG7	0	49	191	1	1
HSPB1	REN	0	167	169	1	1
HSPB1	SLC25A40	0	0	152	1	1
HSPB1	UBA2	272	0	285	1	1

Showing 1 to 10 of 1,522 entries

Ontologies

Show entries

Search:


GO:0000502	Cellular Component	proteasome complex	part_of	ISS
GO:0001533	Cellular Component	cornified envelope	located_in	IEA
GO:0001932	Biological Process	regulation of protein phosphorylation	involved_in	IMP
GO:0003723	Molecular Function	RNA binding	enables	HDA
GO:0005080	Molecular Function	protein kinase C binding	enables	ISS
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0005615	Cellular Component	extracellular space	located_in	HDA
GO:0005634	Cellular Component	nucleus	is_active_in	IBA
GO:0005634	Cellular Component	nucleus	located_in	IDA
GO:0005737	Cellular Component	cytoplasm	is_active_in	IBA

Showing 1 to 10 of 50 entries

Pathways

Show entries

Search:


Apoptosis-related network due to altered Notch3 in ovarian cancer (WP2864)	WikiPathways	WP2864_r108133
ATM signaling in development and disease (WP3878)	WikiPathways	WP3878_r123399
AUF1 (hnRNP D0) binds and destabilizes mRNA	Reactome	R-HSA-450408
ESR-mediated signaling	Reactome	R-HSA-8939211
Extra-nuclear estrogen signaling	Reactome	R-HSA-9009391
Extracellular vesicles in the crosstalk of cardiac cells (WP4300)	WikiPathways	WP4300_r123361
Fas ligand pathway and stress induction of heat shock proteins (WP314)	WikiPathways	WP314_r121827
Ferroptosis (WP4313)	WikiPathways	WP4313_r123507
IL-18 signaling pathway (WP4754)	WikiPathways	WP4754_r115147
Intracellular trafficking proteins involved in CMT neuropathy (WP4856)	WikiPathways	WP4856_r113654

Showing 1 to 10 of 22 entries

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_001540	5	mRNA	None	NC_000007	Reference