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IAPP

islet amyloid polypeptide
General Information
Name islet amyloid polypeptide
Alias
  • islet amyloid polypeptide
  • Islet amyloid polypeptide (diabetes-associated peptide; amylin)
  • amylin
  • diabetes-associated peptide
  • insulinoma amyloid peptide
Gene_family Neuropeptides
organism Homo sapiens
entrez_id 3375
location 12p12.1
transcript_count 2
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
    Stringdb Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family
    nextProt Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
IAPP BioGRID TRIP6 GeneID BioGRID Affinity Capture-MS
IAPP BioGRID SNCA GeneID BioGRID Co-localization
IAPP BioGRID CSK GeneID BioGRID Synthetic Lethality
IAPP BioGRID P4HB GeneID BioGRID Affinity Capture-Western
IAPP Protein COL25A1 GeneID HPRD
IAPP Protein RAMP2 GeneID HPRD
IAPP Protein RAMP1 GeneID HPRD
IAPP Protein PDX1 GeneID HPRD
IAPP Protein PCSK2 GeneID HPRD
IAPP Protein PCSK1 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
IAPP ATF6 0 0 182 196 1 2
IAPP TCF7L2 0 0 251 267 1 1
IAPP NLRC4 0 0 249 248 1 2
IAPP APOA1 0 500 233 600 1 1
IAPP SLCO1A2 0 0 162 161 1 1
IAPP VIP 0 300 390 571 1 1
IAPP INSL5 0 0 234 316 1 1
IAPP TLR4 0 0 228 227 1 2
IAPP CST3 0 500 211 609 1 1
IAPP GAPDH 0 0 234 234 1 2
IAPP SLC5A4 0 0 517 517 1 1
IAPP MAPK8IP1 0 0 134 181 1 1
IAPP AKT1 0 0 308 330 1 2
IAPP APLN 0 0 166 165 1 1
IAPP RAMP3 0 500 939 968 1 1
IAPP PPARG 0 0 391 390 1 2
IAPP CD4 0 0 218 218 1 2
IAPP SLC31A2 0 0 113 168 1 1
IAPP CALCR 0 800 964 992 1 1
IAPP ADCYAP1 0 500 336 656 1 1
IAPP PTHLH 0 500 140 551 1 1
IAPP KISS1 0 0 193 193 1 1
IAPP TLL1 0 0 0 250 1 1
IAPP FOXA1 0 0 351 356 1 1
IAPP CPE 0 0 459 517 1 1
IAPP UCN 0 0 240 632 1 1
IAPP COL25A1 213 0 416 520 1 1
IAPP SERPINI1 0 0 0 183 1 1
IAPP ITM2B 0 500 232 599 1 1
IAPP ENTPD3 0 0 96 158 1 1
IAPP MGAM 0 0 654 654 1 1
IAPP TGFBI 0 300 0 300 1 1
IAPP SCGN 0 0 143 291 1 1
IAPP PYCARD 0 0 274 274 1 2
IAPP NLRP7 0 0 137 190 1 1
IAPP SHBG 0 0 181 181 1 1
IAPP NPPA 0 300 72 392 1 1
IAPP FGF21 0 0 321 321 1 2
IAPP GRIA4 0 0 67 161 1 1
IAPP TH 0 0 181 181 1 2
IAPP FTO 0 0 134 188 1 2
IAPP FOXM1 0 0 385 384 1 1
IAPP NGF 0 0 150 173 1 2
IAPP CPA1 0 0 234 348 1 1
IAPP APOA4 0 500 292 645 1 1
IAPP NIT1 0 0 265 265 1 1
IAPP IFNG 0 0 134 193 1 2
IAPP CCK 0 0 800 803 1 1
IAPP MED14 0 0 0 303 1 1
IAPP CTRC 0 0 112 216 1 1
IAPP GAST 0 0 469 502 1 1
IAPP CREB1 0 0 176 176 1 2
IAPP RTN4 0 0 46 181 1 1
IAPP LPA 0 0 203 203 1 1
IAPP ABCA12 0 0 0 191 1 1
IAPP KCNJ11 0 0 423 459 1 1
IAPP MBOAT4 0 0 264 371 1 1
IAPP GP2 0 0 0 156 1 1
IAPP SYCN 0 0 184 230 1 1
IAPP SLC30A8 0 0 503 535 1 1
IAPP DNAJB1 0 0 155 164 1 2
IAPP UCP2 0 0 203 205 1 2
IAPP GPHB5 0 500 0 499 1 1
IAPP EIF2AK3 0 0 413 413 1 2
IAPP LYZ 0 500 53 506 1 1
IAPP HNF4A 0 0 185 185 1 1
IAPP A2M 0 0 141 156 1 1
IAPP IL6 0 0 392 400 1 2
IAPP MTOR 0 0 181 181 1 2
IAPP NLRP1 0 0 284 284 1 1
IAPP APOE 0 0 621 621 1 2
IAPP OXT 0 0 325 325 1 1
IAPP SLC2A4 0 0 321 325 1 1
IAPP MB 0 0 202 206 1 2
IAPP SAA1 0 500 180 572 1 1
IAPP BGLAP 0 0 217 217 1 1
IAPP TNFSF11 0 0 181 181 1 2
IAPP MRPS26 0 0 0 181 1 1
IAPP TLL2 0 0 0 206 1 1
IAPP GPHA2 0 500 0 499 1 1
IAPP PSEN2 0 0 181 202 1 1
IAPP CRCP 0 0 233 268 1 1
IAPP RHO 0 0 167 167 1 2
IAPP MC4R 0 0 456 478 1 1
IAPP KRT19 0 0 183 214 1 1
IAPP CDKAL1 0 0 170 181 1 1
IAPP VIPR2 0 0 165 181 1 1
IAPP UCN3 0 0 371 438 1 1
IAPP TRPV4 0 0 181 211 1 1
IAPP ODAM 0 300 61 314 1 1
IAPP APP 0 500 614 802 1 2
IAPP NPVF 0 0 0 158 1 1
IAPP DYNLRB2 0 0 60 649 1 1
IAPP TRPV1 0 0 148 167 1 2
IAPP REG3A 0 0 218 218 1 1
IAPP ASTL 0 0 0 207 1 1
IAPP DYNLRB1 0 0 0 463 1 1
IAPP ADIPOR2 0 0 126 152 1 1
IAPP FGA 0 500 88 524 1 1
IAPP CXCL8 0 0 181 181 1 2
IAPP HMOX1 0 0 164 163 1 2
IAPP FSHB 0 500 0 499 1 1
IAPP APOC2 0 0 133 152 1 1
IAPP EIF2S1 0 0 108 160 1 2
IAPP ISL1 0 0 362 396 1 1
IAPP GCK 0 0 602 609 1 1
IAPP CINP 0 0 108 183 1 1
IAPP UCN2 0 0 195 200 1 1
IAPP NKX6-2 0 0 504 504 1 1
IAPP IL1B 0 0 499 502 1 2
IAPP ENSG00000264813 0 0 261 261 1 1
IAPP SFTPD 0 0 0 299 1 1
IAPP TGFA 0 0 194 194 1 1
IAPP STAT3 0 0 260 283 1 2
IAPP TXN 0 0 235 235 1 1
IAPP SMIM20 0 0 66 392 1 1
IAPP PCSK5 0 0 66 169 1 1
IAPP ERN1 0 0 234 234 1 2
IAPP ABCA3 0 0 0 241 1 1
IAPP PCSK2 213 0 509 612 1 1
IAPP GIP 0 300 664 759 1 1
IAPP CAT 0 0 548 618 1 2
IAPP IDE 927 0 830 987 1 1
IAPP CLU 0 0 218 218 1 2
IAPP CHGB 0 0 298 336 1 1
IAPP ENSG00000197584 0 0 91 166 1 1
IAPP PAX4 0 0 501 586 1 1
IAPP JAK2 0 0 148 187 1 2
IAPP FOXA2 0 0 322 336 1 1
IAPP GHRL 0 0 739 739 1 1
IAPP SLC5A1 0 0 290 290 1 1
IAPP MAFA 0 0 284 355 1 1
IAPP DDIT3 0 0 269 282 1 2
IAPP PAM 0 0 310 309 1 1
IAPP PNLIP 0 0 322 356 1 1
IAPP FAM3B 0 0 172 178 1 1
IAPP NPW 0 0 155 241 1 1
IAPP TNFRSF11B 0 0 187 187 1 1
IAPP CRYBA2 0 0 120 181 1 1
IAPP TRH 0 0 364 387 1 1
IAPP NOS3 0 0 156 155 1 2
IAPP SLC2A2 0 0 606 635 1 1
IAPP PC 0 0 167 167 1 1
IAPP CALCB 0 800 829 964 1 1
IAPP INS-IGF2 0 0 217 336 1 1
IAPP NPB 0 0 57 202 1 1
IAPP PFKFB2 0 0 167 259 1 1
IAPP NMS 0 0 67 278 1 1
IAPP TM4SF4 0 0 161 213 1 1
IAPP PYROXD1 0 0 123 210 1 1
IAPP LACTB 0 0 322 321 1 1
IAPP SARM1 0 0 181 181 1 1
IAPP FFAR1 0 0 288 323 1 1
IAPP SERPINE1 0 0 163 163 1 1
IAPP SLC2A1 0 0 260 265 1 2
IAPP CGA 0 500 108 583 1 2
IAPP HTT 0 0 504 515 1 2
IAPP YWHAQ 0 0 244 243 1 1
IAPP MYD88 0 0 142 160 1 2
IAPP METAP2 0 0 183 183 1 1
IAPP GRP 0 0 465 465 1 2
IAPP TP53 0 0 193 193 1 2
IAPP SAG 0 0 162 193 1 1
IAPP IRS1 0 0 363 392 1 2
IAPP LHB 0 500 0 499 1 1
IAPP NPFF 0 0 136 581 1 1
IAPP IRX2 0 0 246 262 1 1
IAPP TMEM27 0 0 314 329 1 1
IAPP TAC4 0 0 172 241 1 1
IAPP CFTR 0 0 152 156 1 2
IAPP RETN 0 0 454 460 1 1
IAPP FURIN 0 0 150 182 1 1
IAPP NPY 0 0 601 625 1 1
IAPP BTC 0 0 163 163 1 1
IAPP PNLIPRP1 0 0 122 197 1 1
IAPP OPA1 0 0 134 155 1 2
IAPP CNR1 0 0 280 280 1 1
IAPP NKX6-1 0 0 519 553 1 1
IAPP CEL 0 0 181 250 1 1
IAPP PCSK1N 0 0 391 391 1 1
IAPP SLC30A10 0 0 459 459 1 1
IAPP IGF1 0 0 400 400 1 2
IAPP ICA1 0 0 142 176 1 1
IAPP MNX1 0 0 203 244 1 1
IAPP ADM5 0 0 211 245 1 1
IAPP GCG 0 300 857 904 1 1
IAPP SCG5 0 0 332 364 1 1
IAPP STC1 0 0 101 153 1 1
IAPP ADM2 0 500 701 854 1 1
IAPP TAS1R2 0 0 144 166 1 1
IAPP GPS2 0 0 0 224 1 1
IAPP TXNIP 0 0 425 438 1 2
IAPP SLC2A3 0 0 182 187 1 1
IAPP CHGA 0 0 470 492 1 1
IAPP ZMPSTE24 0 0 181 181 1 1
IAPP PNLIPRP3 0 0 0 160 1 1
IAPP GH1 0 0 181 181 1 1
IAPP TAC3 0 0 96 152 1 1
IAPP G6PC 0 0 357 372 1 1
IAPP MEFV 0 0 264 265 1 1
IAPP AMY2A 0 0 261 261 1 1
IAPP MAP2 0 0 94 156 1 2
IAPP P4HB 270 0 132 339 1 2
IAPP NTS 0 0 324 323 1 1
IAPP NMB 0 0 160 172 1 1
IAPP INSL3 0 500 82 534 1 1
IAPP GNAQ 0 0 171 171 1 1
IAPP ABCA2 0 0 0 241 1 1
IAPP CELA1 0 0 227 251 1 1
IAPP PTMA 0 0 139 209 1 1
IAPP SNAP25 0 0 164 163 1 1
IAPP TNF 0 0 328 341 1 2
IAPP PPARGC1A 0 0 194 194 1 2
IAPP TPH1 0 0 134 205 1 1
IAPP HTR2C 0 0 171 181 1 1
IAPP PTPRN2 0 0 260 260 1 1
IAPP CLPS 0 0 112 153 1 1
IAPP REG1A 0 0 81 187 1 1
IAPP WFS1 0 0 270 285 1 1
IAPP HTR1B 0 0 134 153 1 1
IAPP MC3R 0 0 266 280 1 1
IAPP TOR2A 0 0 95 260 1 1
IAPP IL18 0 0 293 294 1 2
IAPP BDNF 0 0 184 183 1 2
IAPP NES 0 0 142 161 1 2
IAPP ATG5 0 0 134 162 1 2
IAPP LRMP 0 0 74 214 1 1
IAPP CRH 0 300 322 505 1 1
IAPP ACHE 0 0 142 156 1 2
IAPP LPL 0 0 164 163 1 1
IAPP PPARA 0 0 249 248 1 2
IAPP PPY 0 0 740 764 1 1
IAPP SYP 0 0 209 209 1 1
IAPP XBP1 0 0 213 226 1 2
IAPP LTF 0 300 44 302 1 1
IAPP PMEL 0 0 194 205 1 1
IAPP HSPA4 0 0 181 181 1 1
IAPP GCGR 0 0 391 391 1 1
IAPP PTPN1 0 0 233 233 1 1
IAPP EGF 0 0 161 161 1 2
IAPP HNF1A 0 0 260 260 1 1
IAPP AKR1B1 0 0 181 181 1 1
IAPP PRL 0 300 310 499 1 1
IAPP ASIC5 0 0 92 155 1 1
IAPP CTSB 0 0 261 261 1 2
IAPP PCSK1 213 0 401 560 1 1
IAPP SIRT1 0 0 212 212 1 2
IAPP DLK1 0 0 156 155 1 1
IAPP INSM2 0 0 124 221 1 1
IAPP BACE1 270 0 341 502 1 2
IAPP POMC 0 300 518 659 1 1
IAPP GNRH2 0 0 108 351 1 1
IAPP MAZ 0 0 504 504 1 1
IAPP MAP3K5 0 0 145 166 1 1
IAPP HMGB1 0 0 155 243 1 2
IAPP SCTR 0 0 212 212 1 1
IAPP CYCS 0 0 181 403 1 2
IAPP NUCB1 0 0 135 227 1 1
IAPP CALCA 0 800 856 973 1 1
IAPP GALP 0 0 134 161 1 1
IAPP ABCA5 0 0 0 241 1 1
IAPP NPS 0 300 181 417 1 1
IAPP GAL 0 0 294 294 1 1
IAPP PTH2 0 500 323 653 1 1
IAPP MC5R 0 0 72 388 1 1
IAPP FN1 0 0 142 159 1 2
IAPP ADIPOQ 0 0 505 505 1 2
IAPP CASR 0 0 204 240 1 2
IAPP SSTR1 0 0 193 260 1 1
IAPP MAPK8 0 0 160 159 1 2
IAPP CORT 0 0 142 220 1 1
IAPP P2RX7 0 0 96 152 1 2
IAPP REG1B 0 0 139 230 1 1
IAPP RAMP2 213 500 873 947 1 1
IAPP PRNP 0 0 629 629 1 2
IAPP CRHR2 0 0 150 180 1 1
IAPP FAM206A 0 0 174 174 1 1
IAPP VR1 0 0 148 167 1 1
IAPP CALCRL 0 800 830 966 1 1
IAPP TRAM2 0 0 70 324 1 1
IAPP AVP 0 300 108 350 1 1
IAPP IL1A 0 0 201 201 1 1
IAPP ATG7 0 0 167 172 1 2
IAPP TAC1 0 0 391 390 1 1
IAPP GABRB1 0 0 0 153 1 1
IAPP ABCA1 0 0 150 672 1 2
IAPP ABCC8 0 0 460 471 1 1
IAPP PAX6 0 0 323 323 1 1
IAPP SYTL4 0 0 155 181 1 1
IAPP IL10 0 0 180 179 1 2
IAPP DBH 0 0 211 221 1 1
IAPP HHEX 0 0 217 222 1 1
IAPP DPP4 0 0 681 681 1 1
IAPP BCHE 0 0 139 164 1 1
IAPP GLP2R 0 0 156 162 1 1
IAPP NAMPT 0 0 193 193 1 2
IAPP MLXIPL 0 0 180 180 1 1
IAPP MLN 0 0 270 270 1 2
IAPP NMU 0 0 234 234 1 1
IAPP FNDC5 0 0 209 209 1 1
IAPP IGF2 0 0 387 386 1 1
IAPP CTRB1 0 0 270 342 1 1
IAPP GAD2 0 0 392 392 1 1
IAPP APMAP 0 0 67 195 1 1
IAPP SCG2 0 0 134 166 1 1
IAPP MFGE8 0 300 266 464 1 1
IAPP TSPAN6 0 0 53 198 1 1
IAPP AGER 0 0 290 290 1 2
IAPP AIM2 0 0 273 273 1 2
IAPP NEUROG3 0 0 454 471 1 1
IAPP CCL28 0 0 379 379 1 1
IAPP LALBA 0 0 153 168 1 1
IAPP AGRP 0 0 517 527 1 1
IAPP LHCGR 0 0 445 445 1 1
IAPP CCKBR 0 0 203 220 1 1
IAPP CELA2A 0 0 125 183 1 1
IAPP LEP 0 0 984 984 1 1
IAPP NPTX2 0 0 150 281 1 1
IAPP VAMP2 0 0 154 153 1 1
IAPP SCT 0 300 459 613 1 1
IAPP RFX6 0 0 186 222 1 1
IAPP PTH2R 0 0 124 166 1 1
IAPP ADIPOR1 0 0 142 185 1 1
IAPP CDK5 0 0 202 202 1 2
IAPP GIPR 0 0 247 247 1 1
IAPP UCP1 0 0 245 250 1 2
IAPP FAM134B 0 0 95 163 1 1
IAPP SREBF1 0 0 138 157 1 1
IAPP PTH1R 0 0 55 150 1 1
IAPP SLC2A14 0 0 188 193 1 1
IAPP FAP 0 0 275 275 1 2
IAPP NLRP6 0 0 169 169 1 1
IAPP PCIF1 0 0 96 173 1 1
IAPP VEGFA 0 0 151 159 1 2
IAPP ADRB3 0 0 154 154 1 1
IAPP HSPG2 0 0 481 481 1 1
IAPP MME 0 0 264 310 1 1
IAPP RAP1GAP2 0 0 60 226 1 1
IAPP LEPR 0 0 468 501 1 1
IAPP KCNMB2 0 0 90 165 1 1
IAPP KNG1 0 0 181 181 1 1
IAPP CCL2 0 0 286 286 1 2
IAPP FFAR4 0 0 181 204 1 1
IAPP ALB 0 0 414 473 1 2
IAPP CD68 0 0 161 162 1 2
IAPP CASP8 0 0 161 161 1 2
IAPP FIGF 0 0 0 213 1 1
IAPP PSEN1 0 0 345 353 1 2
IAPP ABCA4 0 0 0 241 1 1
IAPP CRP 0 0 321 321 1 2
IAPP CCKAR 0 0 323 339 1 1
IAPP SSTR2 0 0 218 235 1 1
IAPP CASP3 0 0 338 362 1 2
IAPP PRSS1 0 0 123 186 1 1
IAPP NEUROD1 0 0 466 491 1 1
IAPP HCRT 0 0 391 432 1 1
IAPP APCS 0 0 324 323 1 1
IAPP BACE2 270 0 325 504 1 1
IAPP CELA3B 0 0 244 339 1 1
IAPP C4BPA 0 0 0 216 1 1
IAPP DBI 0 0 55 154 1 1
IAPP NLRP3 0 0 501 509 1 2
IAPP PRLH 0 0 260 270 1 1
IAPP VEGFC 0 0 54 163 1 1
IAPP B2M 0 500 468 722 1 1
IAPP MMP9 0 0 134 152 1 2
IAPP MAPK3 0 0 193 193 1 2
IAPP INSM1 0 0 211 224 1 1
IAPP GLP1R 0 0 600 611 1 1
IAPP ACE 0 0 261 261 1 1
IAPP INS 0 500 988 995 1 2
IAPP RFX7 0 0 65 207 1 1
IAPP ACTB 0 0 261 277 1 2
IAPP REN 0 0 280 284 1 1
IAPP SERPINA12 0 0 134 157 1 1
IAPP PYY 0 0 769 790 1 1
IAPP RLN3 0 500 75 598 1 1
IAPP TRPM3 0 0 119 181 1 1
IAPP CARTPT 0 0 416 416 1 1
IAPP PLA2G1B 0 0 101 176 1 1
IAPP ADM 0 800 760 957 1 2
IAPP GNRH1 0 0 170 169 1 1
IAPP GSN 0 500 261 614 1 1
IAPP SST 0 0 681 707 1 1
IAPP GSK3B 0 0 143 196 1 2
IAPP TTR 0 500 693 850 1 1
IAPP SFTPB 0 0 55 217 1 1
IAPP CPB1 0 0 157 194 1 1
IAPP CRYGD 0 0 207 207 1 1
IAPP PTPRN 0 0 470 470 1 1
IAPP CRYAB 0 0 112 211 1 2
IAPP POU3F4 0 0 171 181 1 1
IAPP ERO1LB 0 0 163 188 1 1
IAPP SOX9 0 0 139 162 1 1
IAPP MS4A1 0 0 298 298 1 1
IAPP COPA 0 0 181 181 1 1
IAPP RLN2 0 500 0 512 1 1
IAPP APLNR 0 0 48 151 1 1
IAPP CSF1 0 0 90 152 1 1
IAPP CDC123 0 0 122 182 1 1
IAPP TMEM106B 0 0 57 156 1 1
IAPP ABCA13 0 0 0 191 1 1
IAPP QRFP 0 0 141 234 1 1
IAPP PMCH 0 0 0 161 1 1
IAPP OSBPL11 0 0 85 289 1 1
IAPP SOD1 0 0 282 282 1 2
IAPP SEMG1 0 300 170 394 1 1
IAPP DNAJC3 0 0 148 177 1 1
IAPP G6PC2 0 0 535 590 1 1
IAPP PDX1 213 900 649 971 1 1
IAPP TVP23B 0 0 157 182 1 1
IAPP FOS 0 0 394 431 1 2
IAPP NKX2-2 0 0 393 408 1 1
IAPP GHSR 0 0 294 313 1 1
IAPP PENK 0 0 94 221 1 1
IAPP CELA3A 0 0 0 180 1 1
IAPP SNCB 0 0 218 239 1 1
IAPP GPR182 0 0 171 298 1 1
IAPP SOCS3 0 0 174 180 1 1
IAPP SSTR5 0 0 218 298 1 1
IAPP CAPN2 0 0 154 243 1 2
IAPP APLP1 0 0 164 163 1 1
IAPP GHRH 0 300 260 459 1 1
IAPP TSHB 0 500 90 535 1 1
IAPP FOXO1 0 0 234 236 1 2
IAPP RBP4 0 0 150 176 1 1
IAPP SSTR3 0 0 135 191 1 1
IAPP PTH 0 500 322 646 1 1
IAPP PDYN 0 0 172 201 1 1
IAPP VIPR1 0 0 242 320 1 1
IAPP RAMP1 213 500 941 975 1 1
IAPP HSPA5 0 0 205 218 1 2
IAPP CD8A 0 0 204 204 1 1
IAPP UCHL1 0 0 142 235 1 2
IAPP IRS2 0 0 321 352 1 1
IAPP GPR119 0 0 141 186 1 1
IAPP SLC5A2 0 0 519 519 1 1
IAPP AIF1 0 0 181 181 1 2
IAPP TLR2 0 0 161 161 1 2
IAPP ATXN3 0 0 181 181 1 2
IAPP FFAR2 0 0 167 177 1 1
IAPP PLAT 0 0 445 445 1 1
IAPP MAPT 0 0 779 779 1 2
IAPP SNCA 0 300 824 873 1 2
IAPP PTF1A 0 0 289 320 1 1
IAPP ARRDC4 0 0 95 158 1 1
IAPP LRP1 0 0 149 186 1 1
IAPP CASP1 0 0 418 434 1 2
IAPP CDK5R1 0 0 82 178 1 1
IAPP JUN 0 0 260 260 1 2
IAPP UTS2 0 0 62 151 1 1
IAPP MAFB 0 0 241 240 1 1
IAPP GLIS3 0 0 185 190 1 1
IAPP RRAGD 0 0 108 172 1 1
IAPP BCL2L11 0 0 107 168 1 2
IAPP GABBR1 0 0 155 154 1 1
IAPP SERPINA1 0 0 135 158 1 2
IAPP SI 0 0 662 662 1 1
IAPP MCHR1 0 0 140 207 1 1
IAPP AMY2B 0 0 685 685 1 1
IAPP PSMD9 0 0 539 539 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0001540 Molecular Function amyloid-beta binding enables TAS
GO:0005179 Molecular Function hormone activity enables IEA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0008289 Molecular Function lipid binding enables EXP
GO:0005515 Molecular Function protein binding enables IPI
GO:0048018 Molecular Function receptor ligand activity enables IDA
GO:0005102 Molecular Function signaling receptor binding enables IPI
GO:0097647 Biological Process amylin receptor signaling pathway involved_in ISS
GO:0006915 Biological Process apoptotic process involved_in TAS
GO:0045453 Biological Process bone resorption involved_in IEA
GO:0007267 Biological Process cell-cell signaling involved_in TAS
GO:0042755 Biological Process eating behavior involved_in IEA
GO:1905907 Biological Process negative regulation of amyloid fibril formation involved_in TAS
GO:0045779 Biological Process negative regulation of bone resorption involved_in IEA
GO:0010823 Biological Process negative regulation of mitochondrion organization involved_in TAS
GO:0045671 Biological Process negative regulation of osteoclast differentiation involved_in IEA
GO:0031333 Biological Process negative regulation of protein-containing complex assembly involved_in TAS
GO:0030316 Biological Process osteoclast differentiation involved_in IEA
GO:0043410 Biological Process positive regulation of MAPK cascade involved_in NAS
GO:0043065 Biological Process positive regulation of apoptotic process involved_in TAS
GO:0043950 Biological Process positive regulation of cAMP-mediated signaling involved_in IDA
GO:0050850 Biological Process positive regulation of calcium-mediated signaling involved_in IGI
GO:0010739 Biological Process positive regulation of protein kinase A signaling involved_in IGI
GO:0019233 Biological Process sensory perception of pain involved_in IEA
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IBA
Pathways
Name DB ID
Developmental Biology Reactome R-HSA-1266738
Signal Transduction Reactome R-HSA-162582
Regulation of beta-cell development Reactome R-HSA-186712
Regulation of gene expression in beta cells Reactome R-HSA-210745
Signaling by GPCR Reactome R-HSA-372790
Class B/2 (Secretin family receptors) Reactome R-HSA-373080
GPCR downstream signalling Reactome R-HSA-388396
Metabolism of proteins Reactome R-HSA-392499
G alpha (s) signalling events Reactome R-HSA-418555
Calcitonin-like ligand receptors Reactome R-HSA-419812
GPCR ligand binding Reactome R-HSA-500792
Amyloid fiber formation Reactome R-HSA-977225
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001329201 2 mRNA transcript variant 2 NC_000012 Reference
NM_000415 3 mRNA transcript variant 1 NC_000012 Reference