STING1

stimulator of interferon response cGAMP interactor 1

General Information

Name	stimulator of interferon response cGAMP interactor 1
Alias	stimulator of interferon genes protein N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner endoplasmic reticulum IFN stimulator endoplasmic reticulum interferon stimulator mitochondrial mediator of IRF3 activation stimulator of interferon protein sting 1 transmembrane protein 173
Gene_family
organism	Homo sapiens
entrez_id	340061
location	5q31.2
transcript_count	3
exon_count	8

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

nextProt (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230).

Interactions

NCBI

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STING1	BioGRID	IFI16	GeneID	BioGRID	Affinity Capture-Western; Co-localization; Reconstituted Complex
STING1	BioGRID	USP35	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STING1	BioGRID	ORF3a	GeneID	BioGRID	Affinity Capture-Western
STING1	BioGRID	ORF1ab	GeneID	BioGRID	Affinity Capture-Western
STING1	BioGRID	TBK1	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western
STING1	BioGRID	IKBKB	GeneID	BioGRID	Affinity Capture-Western
STING1	BioGRID	TRIM56	GeneID	BioGRID	Affinity Capture-Western
STING1	BioGRID	RNF26	GeneID	BioGRID	Affinity Capture-Western; Biochemical Activity
STING1	BioGRID	TRIM32	GeneID	BioGRID	Affinity Capture-Western; Biochemical Activity
STING1	BioGRID	REC8	GeneID	BioGRID	Affinity Capture-Western

Showing 1 to 10 of 98 entries

StringDB

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TMEM173	NOD1	0	224	252	2	1
TMEM173	TLR2	0	235	288	2	1
TMEM173	TRAF3	486	469	715	2	1
TMEM173	BECN1	0	203	203	2	1
TMEM173	CASP1	0	406	487	2	1
TMEM173	TFAM	0	182	260	2	1
TMEM173	RIPK2	0	146	214	2	1
TMEM173	MFN1	0	410	410	2	1
TMEM173	EIF2AK2	0	156	155	2	1
TMEM173	TICAM1	0	454	487	2	1

Showing 1 to 10 of 102 entries

Ontologies

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GO:0000045	Biological Process	autophagosome assembly	involved_in	IBA
GO:0000045	Biological Process	autophagosome assembly	involved_in	IDA
GO:0000139	Cellular Component	Golgi membrane	located_in	IDA
GO:0000421	Cellular Component	autophagosome membrane	located_in	IEA
GO:0002218	Biological Process	activation of innate immune response	involved_in	IBA
GO:0002218	Biological Process	activation of innate immune response	involved_in	IDA
GO:0002218	Biological Process	activation of innate immune response	involved_in	IMP
GO:0002221	Biological Process	pattern recognition receptor signaling pathway	involved_in	IDA
GO:0002230	Biological Process	positive regulation of defense response to virus by host	involved_in	IMP
GO:0002753	Biological Process	cytoplasmic pattern recognition receptor signaling pathway	involved_in	IDA

Showing 1 to 10 of 66 entries

Pathways

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Cytosolic DNA-sensing pathway (WP4655)	WikiPathways	WP4655_r123496
Cytosolic sensors of pathogen-associated DNA	Reactome	R-HSA-1834949
Disease	Reactome	R-HSA-1643685
Immune System	Reactome	R-HSA-168256
Infectious disease	Reactome	R-HSA-5663205
Innate Immune System	Reactome	R-HSA-168249
IRF3-mediated induction of type I IFN	Reactome	R-HSA-3270619
Mitochondrial immune response to SARS-CoV-2 (WP5038)	WikiPathways	WP5038_r124641
Neutrophil degranulation	Reactome	R-HSA-6798695
Novel intracellular components of RIG-I-like receptor pathway (WP3865)	WikiPathways	WP3865_r123636

Showing 1 to 10 of 24 entries

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_001367258	1	mRNA	transcript variant 3	NC_000005	Reference
NM_001301738	2	mRNA	transcript variant 2	NC_000005	Reference
NM_198282	4	mRNA	transcript variant 1	NC_000005	Reference