HAdb 2.0 is available now!

IL18

interleukin 18
General Information
Name interleukin 18
Alias
  • interleukin-18
  • IFN-gamma-inducing factor
  • IL-1 gamma
  • iboctadekin
  • interleukin 18 (interferon-gamma-inducing factor)
  • interleukin-1 gamma
Gene_family Interleukins
organism Homo sapiens
entrez_id 3606
location 11q23.1
transcript_count 4
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
    Stringdb Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells; Belongs to the IL-1 family
    nextProt Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
IL18 BioGRID MYO10 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID GTF2H2C GeneID BioGRID Co-fractionation
IL18 BioGRID UNC45A GeneID BioGRID Co-fractionation
IL18 BioGRID EIF4A3 GeneID BioGRID Co-fractionation
IL18 BioGRID TPT1 GeneID BioGRID Co-fractionation
IL18 BioGRID ROCK1 GeneID BioGRID Co-fractionation
IL18 BioGRID PRKDC GeneID BioGRID Co-fractionation
IL18 BioGRID ILF3 GeneID BioGRID Co-fractionation
IL18 BioGRID DIAPH1 GeneID BioGRID Co-fractionation
IL18 BioGRID DFFA GeneID BioGRID Co-fractionation
IL18 BioGRID CDH1 GeneID BioGRID Co-fractionation
IL18 BioGRID CRIPTO GeneID BioGRID Affinity Capture-MS
IL18 BioGRID SERPINB4 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID RAC1 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID GPX4 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID FAM24B GeneID BioGRID Affinity Capture-MS
IL18 BioGRID ZNF747 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID CDK15 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID STX17 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID WASHC3 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID IL1B GeneID BioGRID Affinity Capture-MS
IL18 BioGRID CIT GeneID BioGRID Affinity Capture-MS
IL18 BioGRID E6 GeneID BioGRID Two-hybrid
IL18 BioGRID ADIRF GeneID BioGRID Two-hybrid
IL18 BioGRID MYC GeneID BioGRID Affinity Capture-MS
IL18 BioGRID Cul1 GeneID BioGRID Affinity Capture-MS
IL18 BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
IL18 BioGRID CASK GeneID BioGRID Two-hybrid
IL18 Protein IL1RL2 GeneID HPRD
IL18 Protein IL18RAP GeneID HPRD
IL18 Protein IL18R1 GeneID HPRD
IL18 Protein IL18BP GeneID HPRD
IL18 Protein CASP4 GeneID HPRD
IL18 Protein CASP3 GeneID HPRD
IL18 Protein CASP1 GeneID HPRD
IL18 BioGRID CASP4 GeneID BioGRID Biochemical Activity
IL18 BioGRID CASP1 GeneID BioGRID Biochemical Activity
IL18 BioGRID IL18BP GeneID BioGRID Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
IL18 CD24 0 0 206 206 1 2
IL18 CTAG1B 0 0 208 208 1 1
IL18 ZNF683 0 0 173 173 1 1
IL18 SIRT7 0 0 212 212 1 2
IL18 IL22 0 0 595 595 1 1
IL18 GABARAPL1 0 0 216 216 1 2
IL18 ADORA2A 0 0 277 277 1 1
IL18 UNC93B1 0 0 284 317 1 1
IL18 ICAM1 0 0 662 675 1 2
IL18 BCL10 0 0 321 321 1 1
IL18 MLKL 0 0 458 473 1 2
IL18 IGFBP2 0 0 112 175 1 1
IL18 ITGAV 0 0 166 165 1 1
IL18 NLRP9 0 0 260 269 1 1
IL18 CXCR1 0 0 358 371 1 1
IL18 ESR2 0 0 156 155 1 1
IL18 PTPRC 0 0 560 573 1 1
IL18 CD160 0 0 218 218 1 1
IL18 KLRK1 0 0 653 677 1 1
IL18 CD3D 0 0 181 181 1 1
IL18 PLA2G1B 0 0 310 309 1 1
IL18 TNNI3 0 0 180 179 1 1
IL18 CRLF2 0 0 195 195 1 1
IL18 TLR5 0 0 652 659 1 1
IL18 CCL18 0 0 371 406 1 1
IL18 CXCL12 0 0 518 518 1 2
IL18 GPR29 0 0 503 524 1 1
IL18 BAX 0 0 181 187 1 2
IL18 PYY 0 0 180 179 1 1
IL18 IL36A 0 0 394 555 1 1
IL18 TIMP1 0 0 469 481 1 1
IL18 TNFRSF14 0 0 260 260 1 1
IL18 CSF2RA 0 0 150 191 1 1
IL18 CDKN1A 0 0 150 153 1 2
IL18 SPP1 0 0 465 476 1 2
IL18 IFNAR2 0 0 325 325 1 1
IL18 EPCAM 0 0 217 217 1 2
IL18 PARP1 0 0 241 240 1 2
IL18 RHOA 0 0 260 260 1 2
IL18 GSR 0 0 171 171 1 1
IL18 BID 0 0 167 167 1 2
IL18 CD1C 0 0 400 410 1 1
IL18 THY1 0 0 297 312 1 1
IL18 ANGPT1 0 0 231 230 1 1
IL18 ABCG1 0 0 242 241 1 2
IL18 SIRT3 0 0 262 262 1 2
IL18 PROM1 0 0 171 171 1 2
IL18 KEAP1 0 0 240 241 1 2
IL18 MMP9 0 0 595 603 1 2
IL18 B2M 0 0 470 494 1 1
IL18 MAPK3 0 900 424 941 1 2
IL18 BNIP3 0 0 202 226 1 2
IL18 SQSTM1 0 0 321 335 1 2
IL18 MICB 0 0 358 358 1 1
IL18 FCGR2B 0 0 402 431 1 1
IL18 KIR3DL3 0 0 341 341 1 1
IL18 ANXA4 0 0 108 166 1 1
IL18 ADAMTS5 0 0 166 165 1 1
IL18 IL17B 0 0 279 279 1 1
IL18 CIT 270 0 0 270 1 1
IL18 EMR2 0 0 90 186 1 1
IL18 SERPINA12 0 0 136 168 1 1
IL18 ENSG00000258555 0 0 204 204 1 1
IL18 ATG13 0 0 160 159 1 2
IL18 CCL15 0 0 262 293 1 1
IL18 GAS6 0 0 166 165 1 1
IL18 CLDN5 0 0 147 171 1 1
IL18 SELP 0 0 452 452 1 1
IL18 INS 0 0 564 564 1 2
IL18 ACTB 0 0 561 594 1 2
IL18 CD40 0 0 617 635 1 2
IL18 ITGB7 0 0 151 169 1 1
IL18 FGF1 0 0 193 193 1 1
IL18 NLRX1 0 0 465 465 1 2
IL18 C1S 0 0 201 201 1 1
IL18 FPR2 0 0 250 250 1 1
IL18 GBP7 0 0 155 165 1 1
IL18 SELL 0 0 509 519 1 1
IL18 PTGDR2 0 0 264 264 1 1
IL18 CLEC2D 0 0 206 206 1 1
IL18 CEBPA 0 0 184 202 1 1
IL18 P2RX2 0 0 161 161 1 1
IL18 CRP 0 0 737 737 1 2
IL18 PSEN1 0 0 268 268 1 2
IL18 SLAMF6 0 0 285 284 1 1
IL18 PANX2 0 0 182 181 1 1
IL18 LBP 0 0 264 264 1 1
IL18 HSP90AA1 0 0 294 294 1 2
IL18 IL3 0 0 724 724 1 1
IL18 LTB 0 0 284 296 1 1
IL18 TFEB 0 0 154 153 1 2
IL18 LRRC3 0 0 286 286 1 1
IL18 MBL2 0 0 340 340 1 1
IL18 HPGDS 0 0 261 261 1 1
IL18 IL21 0 0 216 707 1 1
IL18 TYK2 0 0 392 392 1 1
IL18 FABP3 0 0 181 200 1 1
IL18 FUT2 0 0 167 167 1 1
IL18 TNIP3 0 0 134 176 1 1
IL18 TMEM173 0 0 324 340 1 1
IL18 TAPBP 0 0 161 161 1 1
IL18 TFF3 0 0 294 294 1 1
IL18 JUN 0 800 517 901 1 2
IL18 CCL24 0 0 382 389 1 1
IL18 NLRP13 0 0 240 239 1 1
IL18 SIGLEC1 0 0 287 304 1 1
IL18 KL 0 0 170 169 1 2
IL18 SERPINA1 0 0 297 341 1 2
IL18 ENSG00000173366 0 0 689 710 1 1
IL18 BCL2L11 0 0 256 256 1 2
IL18 SERPINB2 0 0 127 370 1 1
IL18 ITGAL 0 0 340 354 1 1
IL18 IL10RA 0 0 465 476 1 1
IL18 GZMA 0 0 395 408 1 1
IL18 NPPB 0 0 180 179 1 1
IL18 FFAR2 0 0 391 390 1 1
IL18 MAP2K3 0 0 194 194 1 1
IL18 ZBTB16 0 0 335 335 1 1
IL18 PADI4 0 0 170 169 1 1
IL18 JAK3 0 0 286 301 1 1
IL18 PIK3CG 0 0 170 169 1 1
IL18 GBP4 0 0 133 180 1 1
IL18 HLA-DRB1 0 0 260 265 1 1
IL18 CAV1 0 0 171 171 1 2
IL18 TNFSF10 0 0 469 482 1 2
IL18 HSPA1A 0 0 261 270 1 1
IL18 COL18A1 0 0 261 261 1 1
IL18 AIF1 0 0 468 468 1 2
IL18 PVR 0 0 292 292 1 1
IL18 CASP1 463 900 913 997 1 2
IL18 NOS1 0 0 210 221 1 1
IL18 CCR3 0 0 417 427 1 1
IL18 GORASP2 0 0 212 212 1 1
IL18 EXOSC4 0 0 94 185 1 1
IL18 CD74 0 0 241 258 1 1
IL18 CD27 0 0 502 506 1 1
IL18 DNTT 0 0 273 273 1 1
IL18 PLAT 0 0 215 215 1 1
IL18 SNCA 0 0 267 267 1 2
IL18 CXCL6 0 0 338 612 1 1
IL18 RUNX3 0 0 218 218 1 1
IL18 MMP2 0 0 421 420 1 2
IL18 TNFRSF13C 0 0 213 213 1 1
IL18 SLAMF1 0 0 279 279 1 1
IL18 RBP4 0 0 261 261 1 1
IL18 TREM2 0 0 285 284 1 1
IL18 TNFSF4 0 0 413 412 1 1
IL18 COL3A1 0 0 141 164 1 1
IL18 TNFRSF8 0 0 261 261 1 1
IL18 IL22RA2 0 0 394 394 1 1
IL18 ANGPT2 0 0 252 252 1 1
IL18 RIPK2 0 0 469 480 1 2
IL18 IL1RAPL2 0 0 573 573 1 1
IL18 TFAM 0 0 155 154 1 2
IL18 CD8A 0 0 754 762 1 1
IL18 IRS2 0 0 180 179 1 1
IL18 SIGLEC7 0 0 181 181 1 1
IL18 CALR 0 0 270 270 1 1
IL18 PSMB8 0 0 210 227 1 1
IL18 RAB27A 0 0 181 181 1 1
IL18 P2RY1 0 0 184 201 1 1
IL18 MFN1 0 0 142 151 1 2
IL18 IGFBP3 0 0 180 179 1 2
IL18 LTC4S 0 0 134 221 1 1
IL18 EIF2AK2 0 0 211 233 1 2
IL18 HAVCR2 0 0 428 428 1 1
IL18 COMP 0 0 150 169 1 1
IL18 IL36RN 0 0 563 611 1 1
IL18 P2RY12 0 0 233 255 1 1
IL18 IL7R 0 0 505 505 1 1
IL18 IL37 0 900 867 987 1 1
IL18 CCR5 0 0 556 572 1 1
IL18 CD69 0 0 602 605 1 1
IL18 SOD1 0 0 260 260 1 2
IL18 LTA 0 0 603 663 1 1
IL18 JAG1 0 0 155 154 1 1
IL18 IFNK 0 0 140 336 1 1
IL18 LCK 0 0 268 284 1 1
IL18 NFKBIL1 0 0 94 150 1 1
IL18 LAMP2 0 0 178 190 1 2
IL18 CCRL2 0 0 503 521 1 1
IL18 IL17RA 0 0 452 463 1 1
IL18 CLEC6A 0 0 325 339 1 1
IL18 PVRL2 0 0 266 266 1 1
IL18 TICAM1 0 0 392 392 1 2
IL18 P2RX5 0 0 161 161 1 1
IL18 MSLN 0 0 154 175 1 1
IL18 CYSLTR1 0 0 154 153 1 1
IL18 NLRP8 0 0 160 165 1 1
IL18 FYN 0 0 213 238 1 1
IL18 MX2 0 0 194 211 1 1
IL18 PRF1 0 0 668 674 1 1
IL18 IL2RG 0 0 391 428 1 1
IL18 NR3C1 0 0 285 284 1 1
IL18 CD244 0 0 330 344 1 1
IL18 PDGFA 0 0 145 168 1 1
IL18 CISH 0 0 391 390 1 1
IL18 PTGER4 0 0 274 292 1 1
IL18 CCR1 0 0 454 470 1 1
IL18 KLRF1 0 0 335 339 1 1
IL18 P2RX7 0 0 607 675 1 2
IL18 CTGF 0 0 324 324 1 1
IL18 FLG 0 0 288 288 1 1
IL18 IFIH1 0 0 558 576 1 1
IL18 HIST2H3PS2 0 0 193 193 1 1
IL18 DIABLO 0 0 218 218 1 2
IL18 CLDN3 0 0 173 173 1 1
IL18 VR1 0 0 167 173 1 1
IL18 GPX4 0 0 123 165 1 2
IL18 BATF3 0 0 213 240 1 1
IL18 GSDMB 0 0 223 252 1 1
IL18 MMP16 0 0 96 233 1 1
IL18 IL1F10 0 0 602 645 1 1
IL18 C5AR2 0 0 210 218 1 1
IL18 HLA-DQA1 0 0 251 267 1 1
IL18 HLX 0 0 156 155 1 1
IL18 CALCA 0 0 246 245 1 1
IL18 SERPING1 0 0 155 167 1 1
IL18 ARG1 0 0 504 504 1 2
IL18 MAPK8 0 900 368 934 1 2
IL18 ADIPOQ 0 0 595 595 1 2
IL18 KLRD1 0 0 565 565 1 1
IL18 CPA3 0 0 142 161 1 1
IL18 PCSK1 0 0 179 184 1 1
IL18 ETS1 0 0 209 209 1 1
IL18 NLRP5 0 0 233 301 1 1
IL18 PLAU 0 0 212 228 1 1
IL18 IGFBP1 0 0 155 154 1 1
IL18 IL17A 0 0 805 826 1 2
IL18 CD59 0 0 167 167 1 1
IL18 BMP2 0 0 163 178 1 1
IL18 EGF 0 0 459 459 1 2
IL18 PRTN3 0 0 469 478 1 1
IL18 CYCS 0 0 421 420 1 2
IL18 NRP1 0 0 204 204 1 1
IL18 GADD45B 0 0 218 218 1 1
IL18 TLR7 0 0 662 710 1 2
IL18 DHX36 0 0 188 188 1 1
IL18 MAPK9 0 900 226 919 1 2
IL18 IL13RA2 0 0 175 211 1 1
IL18 CXCL11 0 0 518 518 1 1
IL18 PYHIN1 0 0 294 329 1 1
IL18 CASP9 0 0 392 400 1 2
IL18 IL18BP 270 800 989 998 1 1
IL18 TRAF6 0 0 560 564 1 2
IL18 POMC 0 0 288 288 1 1
IL18 DEFB103B 0 0 319 319 1 1
IL18 PPY 0 0 113 266 1 1
IL18 PPARA 0 0 366 366 1 2
IL18 LPL 0 0 215 215 1 1
IL18 TEK 0 0 210 210 1 1
IL18 ACHE 0 0 181 185 1 2
IL18 CXCL9 0 0 654 676 1 1
IL18 IL12B 0 900 203 939 1 1
IL18 HSPB3 0 0 310 309 1 1
IL18 CYP2E1 0 0 181 181 1 2
IL18 ITGA1 0 0 321 321 1 1
IL18 HSP90B1 0 0 183 183 1 1
IL18 NDUFAB1 0 0 150 181 1 1
IL18 PDE6B 0 0 181 201 1 1
IL18 ISG20 0 0 194 194 1 1
IL18 CCR2 0 0 560 566 1 2
IL18 TRIM5 0 0 156 163 1 1
IL18 DICER1 0 0 235 235 1 1
IL18 CX3CR1 0 0 504 504 1 1
IL18 PYDC1 0 0 347 347 1 1
IL18 PLAUR 0 0 184 208 1 1
IL18 IL12RB2 0 0 415 414 1 1
IL18 TYR 0 0 145 164 1 2
IL18 LIF 0 900 380 935 1 2
IL18 LTF 0 0 173 183 1 1
IL18 XCR1 0 0 249 248 1 1
IL18 HSPA4 0 0 339 339 1 1
IL18 IRF2 0 0 261 261 1 1
IL18 PMEL 0 0 241 240 1 1
IL18 CFD 0 0 229 261 1 1
IL18 TYROBP 0 0 401 431 1 1
IL18 CASP7 0 0 394 398 1 1
IL18 MME 0 0 147 166 1 1
IL18 IL17RE 0 0 181 191 1 1
IL18 ANXA3 0 0 95 155 1 1
IL18 ITLN1 0 0 277 277 1 1
IL18 ITGB1 0 0 181 203 1 1
IL18 ALB 0 0 605 632 1 2
IL18 CASP8 0 0 562 608 1 2
IL18 CD68 0 0 556 578 1 2
IL18 LRRFIP1 0 0 220 220 1 1
IL18 KNG1 0 0 233 232 1 1
IL18 CCL2 0 900 763 976 1 2
IL18 GYPC 0 0 208 208 1 1
IL18 OTULIN 0 0 149 168 1 1
IL18 CD276 0 0 466 465 1 1
IL18 LEPR 0 0 261 261 1 1
IL18 IDO1 0 0 400 400 1 1
IL18 CARD17 0 0 215 543 1 1
IL18 IL16 0 0 655 662 1 1
IL18 IFI44L 0 0 97 159 1 1
IL18 MYLK 0 0 151 150 1 1
IL18 SERPINB1 0 0 117 289 1 1
IL18 CNTF 0 0 202 222 1 1
IL18 TNFRSF10A 0 0 270 295 1 1
IL18 FAM213A 0 0 157 156 1 1
IL18 IL17F 0 0 526 538 1 1
IL18 BIRC3 0 0 234 285 1 1
IL18 ANXA8 0 0 183 224 1 1
IL18 SPARC 0 0 170 169 1 2
IL18 SMAD3 0 0 310 309 1 2
IL18 IL9 0 0 659 661 1 1
IL18 IL27 0 0 272 272 1 1
IL18 IL4 0 900 804 980 1 1
IL18 SCARB1 0 0 150 168 1 1
IL18 SIRPA 0 0 243 259 1 1
IL18 CLEC2B 0 0 167 167 1 1
IL18 EP300 0 0 181 181 1 2
IL18 ADIPOR1 0 0 193 193 1 1
IL18 F7 0 0 260 260 1 1
IL18 MFGE8 0 0 170 169 1 1
IL18 CD33 0 0 290 307 1 1
IL18 BMP7 0 0 156 155 1 1
IL18 MB21D1 0 0 505 513 1 1
IL18 DEFB4B 0 0 263 263 1 1
IL18 CDH1 0 0 334 334 1 2
IL18 NCF4 0 0 147 168 1 1
IL18 TMEM201 0 0 204 204 1 1
IL18 PLG 0 0 391 404 1 1
IL18 GLIS2 0 0 202 202 1 1
IL18 C8B 0 0 50 195 1 1
IL18 TRIM21 0 0 236 236 1 1
IL18 C4B 0 0 261 278 1 1
IL18 CP 0 0 141 181 1 1
IL18 SIRT6 0 0 217 217 1 2
IL18 DDX41 0 0 265 265 1 1
IL18 DDX58 0 0 651 658 1 1
IL18 AIM2 0 0 806 816 1 2
IL18 PYDC2 0 0 218 218 1 1
IL18 MAPKAPK2 0 0 108 245 1 1
IL18 PLA2G10 0 0 157 156 1 1
IL18 AGER 0 0 452 452 1 2
IL18 CCR10 0 0 230 229 1 1
IL18 TRADD 0 0 320 319 1 1
IL18 ABCA1 0 0 286 301 1 2
IL18 IAPP 0 0 293 294 1 2
IL18 MAVS 0 0 518 526 1 2
IL18 CRYGC 0 0 404 404 1 1
IL18 GBP1 0 0 254 285 1 1
IL18 AVP 0 0 156 155 1 1
IL18 CCL4 0 900 681 969 1 1
IL18 CEACAM1 0 0 167 167 1 1
IL18 IL1A 0 900 805 980 1 1
IL18 MAF 0 0 260 260 1 1
IL18 NFIL3 0 0 325 325 1 1
IL18 GLMN 0 0 122 152 1 1
IL18 DPP4 0 0 291 290 1 1
IL18 NR3C2 0 0 150 172 1 1
IL18 EREG 0 0 150 192 1 1
IL18 BCHE 0 0 158 157 1 1
IL18 BSG 0 0 205 205 1 1
IL18 DEFB103A 0 0 315 315 1 1
IL18 TOR1A 0 0 181 181 1 1
IL18 MYD88 0 0 825 834 1 2
IL18 TNFRSF4 0 0 391 390 1 1
IL18 ADORA3 0 0 268 268 1 1
IL18 EGFR 0 0 345 350 1 2
IL18 CFLAR 0 0 294 294 1 2
IL18 PSTPIP1 0 0 322 321 1 1
IL18 TSLP 0 0 561 562 1 1
IL18 LAMP1 0 0 543 554 1 2
IL18 SLC2A1 0 0 170 169 1 2
IL18 SARM1 0 0 240 239 1 1
IL18 ULBP3 0 0 180 190 1 1
IL18 ESX1 0 0 320 329 1 1
IL18 BCO2 0 0 228 245 1 1
IL18 FADD 0 0 392 392 1 2
IL18 IL20RA 0 0 184 189 1 1
IL18 CFTR 0 0 206 206 1 2
IL18 S100A1 0 0 155 191 1 1
IL18 ALOX15 0 0 201 201 1 1
IL18 TGM2 0 0 180 179 1 2
IL18 IRF9 0 0 324 323 1 1
IL18 PSCA 0 0 150 199 1 1
IL18 TP53 0 0 424 428 1 2
IL18 LCN2 0 0 747 756 1 1
IL18 DCN 0 0 156 155 1 2
IL18 KLRC1 0 0 595 595 1 1
IL18 GIG25 0 0 204 233 1 1
IL18 NFKBIZ 0 0 243 242 1 1
IL18 CD200R1 0 0 294 294 1 1
IL18 TNFRSF11B 0 0 391 390 1 1
IL18 LCP2 0 0 170 189 1 1
IL18 ZBP1 0 0 268 294 1 1
IL18 KIR3DL2 0 0 339 339 1 1
IL18 HDAC2 0 0 138 150 1 1
IL18 MAP3K7 0 0 247 246 1 2
IL18 SELPLG 0 0 181 181 1 1
IL18 NLRP4 0 0 393 392 1 1
IL18 DDIT3 0 0 193 224 1 2
IL18 CAMP 0 0 470 470 1 2
IL18 TRAF1 0 0 204 221 1 1
IL18 FGF7 0 0 235 235 1 1
IL18 CARD9 0 0 417 425 1 1
IL18 MUC5B 0 0 141 166 1 1
IL18 LMNA 0 0 182 188 1 2
IL18 IRAK1 0 0 568 572 1 1
IL18 CSF3 0 900 651 964 1 1
IL18 P2RX4 0 0 402 402 1 1
IL18 PSTPIP2 0 0 215 215 1 1
IL18 NR4A1 0 0 207 207 1 2
IL18 CYBA 0 0 241 240 1 1
IL18 CLU 0 0 310 309 1 2
IL18 CCL26 0 0 325 325 1 1
IL18 HLA-DQB1 0 0 147 223 1 1
IL18 REG3G 0 0 229 249 1 1
IL18 PTX3 0 0 324 323 1 1
IL18 APAF1 0 0 306 306 1 2
IL18 JAK2 0 0 420 420 1 2
IL18 NLRC5 0 0 469 480 1 1
IL18 GHRL 0 0 270 270 1 1
IL18 IFNA2 0 0 531 531 1 1
IL18 CD300C 0 0 161 183 1 1
IL18 HBEGF 0 0 325 325 1 1
IL18 GDNF 0 0 181 181 1 2
IL18 STAT3 0 650 601 855 1 2
IL18 PTPN22 0 0 242 258 1 1
IL18 CD55 0 0 193 193 1 1
IL18 TGFA 0 0 173 207 1 1
IL18 MUC5AC 0 0 195 218 1 1
IL18 CCL25 0 0 269 282 1 1
IL18 MMP15 0 0 70 238 1 1
IL18 GATA3 0 0 519 522 1 1
IL18 MICA 0 0 458 457 1 1
IL18 ERN1 0 0 261 261 1 2
IL18 PI3 0 0 203 232 1 2
IL18 ADAM10 0 0 234 234 1 1
IL18 TREM1 0 0 377 392 1 1
IL18 PPARGC1A 0 0 284 284 1 2
IL18 IGF1R 0 0 145 177 1 2
IL18 SLAMF7 0 0 181 199 1 1
IL18 TRIM33 0 0 95 151 1 1
IL18 IL36G 0 0 323 476 1 1
IL18 TAB2 0 0 283 282 1 2
IL18 IFNA1 0 0 810 810 1 1
IL18 NR0B2 0 0 164 163 1 1
IL18 PARK2 0 0 167 167 1 1
IL18 IFITM3 0 0 208 225 1 1
IL18 IRGM 0 0 369 369 1 2
IL18 IL15 0 0 967 969 1 1
IL18 S100A7 0 0 212 212 1 1
IL18 ITGAE 0 0 469 470 1 1
IL18 MYC 66 0 310 327 1 2
IL18 IL1R1 0 0 947 947 1 1
IL18 ACP5 0 0 184 183 1 1
IL18 IL2RA 0 0 494 505 1 1
IL18 SLC12A3 0 0 543 543 1 1
IL18 MMP17 0 0 58 228 1 1
IL18 CEACAM5 0 0 235 241 1 1
IL18 IL27RA 0 0 341 341 1 1
IL18 CLEC11A 0 0 464 463 1 1
IL18 CECR1 0 0 143 155 1 1
IL18 DHX33 0 0 289 290 1 1
IL18 ADORA1 0 0 260 260 1 1
IL18 CD300A 0 0 175 175 1 1
IL18 TRAF2 0 0 193 213 1 2
IL18 TAB1 0 0 242 241 1 1
IL18 GPX7 0 0 0 188 1 1
IL18 MX1 0 0 392 405 1 1
IL18 MEFV 0 0 813 831 1 1
IL18 ACTA1 0 0 156 167 1 1
IL18 SUCNR1 0 0 134 155 1 1
IL18 LAG3 0 0 344 343 1 1
IL18 IL1RL2 213 0 596 669 1 1
IL18 CHI3L1 0 0 393 392 1 1
IL18 NELFCD 0 0 517 730 1 1
IL18 LY75 0 0 293 293 1 1
IL18 IL12A 0 900 134 930 1 1
IL18 CASP10 0 0 207 272 1 1
IL18 TNFRSF13B 0 0 181 181 1 1
IL18 IL17RC 0 0 292 292 1 1
IL18 CIDEB 0 0 194 194 1 1
IL18 S1PR2 0 0 150 169 1 1
IL18 TDO2 0 0 162 161 1 1
IL18 CLEC4A 0 0 161 179 1 1
IL18 ADAMDEC1 0 0 337 356 1 1
IL18 TNFRSF12A 0 0 243 242 1 1
IL18 OAS3 0 0 134 211 1 1
IL18 SMAD4 0 0 173 173 1 2
IL18 FUT4 0 0 181 181 1 1
IL18 MAP2K1 0 0 185 185 1 1
IL18 PPIF 0 0 167 167 1 1
IL18 CH25H 0 0 169 188 1 1
IL18 MAP3K8 0 0 194 194 1 1
IL18 DHX58 0 0 374 387 1 1
IL18 OSM 0 0 324 323 1 1
IL18 UNK 0 0 218 218 1 1
IL18 C5 0 0 123 207 1 1
IL18 FURIN 0 0 151 150 1 1
IL18 RBCK1 0 0 150 169 1 1
IL18 OASL 0 0 212 250 1 1
IL18 NPY 0 0 144 167 1 1
IL18 AREG 0 0 365 396 1 1
IL18 CCL21 0 0 408 419 1 1
IL18 NLRP12 0 0 596 596 1 1
IL18 PDGFB 0 0 180 179 1 2
IL18 CD80 0 0 607 620 1 2
IL18 UNC13D 0 0 230 253 1 1
IL18 BTN3A1 0 0 155 154 1 1
IL18 LILRB1 0 0 324 323 1 1
IL18 NLRP10 0 0 373 373 1 1
IL18 TDGF1 235 0 0 235 1 1
IL18 RB1CC1 0 0 157 156 1 2
IL18 NFE2L2 0 0 298 298 1 2
IL18 TLR1 0 0 601 634 1 1
IL18 GSDMD 0 0 776 807 1 2
IL18 HCST 0 0 358 372 1 1
IL18 CREB1 0 0 323 323 1 2
IL18 PLCG2 0 0 203 203 1 1
IL18 CCL5 0 900 714 972 1 2
IL18 TGFB3 0 0 290 290 1 1
IL18 DHX9 0 0 155 186 1 1
IL18 ENSG00000260869 186 0 0 186 1 1
IL18 HLA-DQA2 0 0 147 165 1 1
IL18 IFNG 0 0 740 845 1 2
IL18 BIRC2 0 0 263 290 1 1
IL18 IL2RB 0 0 407 456 1 1
IL18 CREBBP 0 0 160 159 1 1
IL18 HLA-DPB1 0 0 155 154 1 1
IL18 PANX3 0 0 170 169 1 1
IL18 KCNJ11 0 0 297 297 1 1
IL18 HAVCR1 0 0 760 760 1 1
IL18 HCAR2 0 0 413 447 1 1
IL18 PFKFB3 0 0 96 170 1 2
IL18 CCL13 0 0 370 370 1 1
IL18 CXCL13 0 0 452 463 1 1
IL18 C5AR1 0 0 323 338 1 1
IL18 TNFSF9 0 0 334 334 1 1
IL18 EPO 0 0 335 344 1 2
IL18 IL1RAPL1 0 0 454 454 1 1
IL18 TNFSF18 0 0 204 224 1 1
IL18 IL4R 0 0 464 475 1 1
IL18 GSDMA 0 0 505 509 1 1
IL18 CLEC4D 0 0 193 193 1 1
IL18 SIRT2 0 0 261 261 1 2
IL18 HSPD1 0 0 261 261 1 1
IL18 LGALS9 0 0 268 301 1 1
IL18 OSMR 0 0 89 184 1 1
IL18 FGF21 0 0 151 222 1 2
IL18 TNFSF13 0 0 170 190 1 1
IL18 ANXA5 0 0 392 418 1 2
IL18 RORA 0 0 161 161 1 1
IL18 CCL4L1 0 0 619 650 1 1
IL18 AOC3 0 0 370 370 1 1
IL18 RELA 0 900 401 937 1 2
IL18 BCL2L1 0 0 378 383 1 2
IL18 SLC5A4 0 0 157 156 1 1
IL18 TCHH 0 0 163 163 1 1
IL18 C1R 0 0 180 186 1 1
IL18 CD7 0 0 171 171 1 1
IL18 NFKB1 0 900 358 934 1 2
IL18 ITGA4 0 0 212 212 1 1
IL18 TAB3 0 0 185 185 1 1
IL18 CASP6 0 0 247 276 1 1
IL18 STAT4 0 900 518 952 1 1
IL18 ACKR4 0 0 244 243 1 1
IL18 MMP20 0 0 0 214 1 1
IL18 TLR10 0 0 414 582 1 1
IL18 CLEC7A 0 0 517 531 1 1
IL18 SH2D1B 0 0 230 229 1 1
IL18 ZAP70 0 0 248 257 1 1
IL18 UMOD 0 0 226 225 1 1
IL18 TRIM25 0 0 241 257 1 1
IL18 KITLG 0 0 401 400 1 1
IL18 NOS2 0 0 468 501 1 2
IL18 CX3CL1 0 0 556 588 1 1
IL18 CD1A 0 0 293 298 1 1
IL18 MAP2K7 0 0 254 254 1 1
IL18 APOA1 0 0 294 294 1 1
IL18 TNFSF15 0 0 531 581 1 1
IL18 GABARAPL2 0 0 218 218 1 2
IL18 CD14 0 0 135 329 1 1
IL18 CD83 0 0 456 467 1 1
IL18 HAMP 0 0 219 219 1 1
IL18 OAS2 0 0 235 287 1 1
IL18 GAPDH 0 0 566 572 1 2
IL18 DNASE1 0 0 178 177 1 1
IL18 ATG14 0 0 163 216 1 2
IL18 CYP1A1 0 0 144 165 1 2
IL18 HDGF 0 0 113 168 1 1
IL18 TNFRSF25 0 0 360 360 1 1
IL18 IL9R 0 0 181 181 1 1
IL18 CD22 0 0 202 239 1 1
IL18 ENO1 0 0 161 161 1 1
IL18 EMR1 0 0 75 403 1 1
IL18 SMAD2 0 0 261 261 1 2
IL18 TLR4 0 0 772 811 1 2
IL18 B3GAT1 0 0 459 459 1 1
IL18 CTSL 0 0 289 288 1 2
IL18 IL6R 0 0 460 476 1 1
IL18 KLK3 0 0 181 181 1 1
IL18 NCR1 0 0 651 658 1 1
IL18 MAPK13 0 0 161 167 1 1
IL18 NCR3 0 0 560 560 1 1
IL18 CXCL8 0 900 826 986 1 2
IL18 IL1B 0 900 912 994 1 2
IL18 NR1H3 0 0 127 204 1 1
IL18 EDN1 0 0 420 430 1 1
IL18 HIF1A 0 0 407 407 1 2
IL18 POSTN 0 0 184 183 1 1
IL18 OAS1 0 0 269 287 1 1
IL18 TRAF5 0 0 207 207 1 1
IL18 SIRT5 0 0 211 211 1 1
IL18 B7RP1 0 0 303 303 1 1
IL18 ERAP1 0 0 161 161 1 1
IL18 IKBKE 0 0 194 244 1 1
IL18 KRT17 0 0 73 173 1 1
IL18 TNFRSF1B 0 0 459 470 1 1
IL18 C3AR1 0 0 268 301 1 1
IL18 PLA2G4A 0 0 181 229 1 1
IL18 CXCR2 0 0 459 470 1 1
IL18 TRPV1 0 0 167 173 1 2
IL18 APP 0 0 366 366 1 2
IL18 MFN2 0 0 180 189 1 2
IL18 EGR1 0 0 230 229 1 2
IL18 SOCS7 0 0 195 195 1 1
IL18 CTNNB1 0 0 334 334 1 2
IL18 FCGR3A 0 0 562 571 1 1
IL18 HRAS 0 0 230 246 1 2
IL18 MAP1LC3A 0 0 145 235 1 2
IL18 SAA1 0 0 325 325 1 1
IL18 CD163 0 0 459 470 1 1
IL18 ADAR 0 0 135 167 1 1
IL18 C4A 0 0 261 278 1 1
IL18 TIMP4 0 0 157 165 1 1
IL18 POTEF 0 0 230 288 1 1
IL18 NLRP1 0 0 877 880 1 1
IL18 MTOR 0 0 391 392 1 2
IL18 APOBEC3G 0 0 150 194 1 1
IL18 SPINK5 0 0 144 167 1 1
IL18 CD40LG 0 0 607 607 1 1
IL18 PTGS1 0 0 306 310 1 1
IL18 MMP1 0 0 401 400 1 1
IL18 NOTCH1 0 0 285 284 1 2
IL18 ENTPD1 0 0 393 392 1 1
IL18 CTAG1A 0 0 208 208 1 1
IL18 HLA-G 0 0 262 262 1 1
IL18 FGF13 0 0 310 309 1 1
IL18 CXCR4 0 0 457 468 1 2
IL18 PIDD1 0 0 135 158 1 1
IL18 IL17D 0 0 260 260 1 1
IL18 OCLN 0 0 370 370 1 1
IL18 GZMB 0 0 605 605 1 1
IL18 TNFRSF1A 0 0 563 572 1 1
IL18 FABP6 0 0 120 175 1 1
IL18 NPHS1 0 0 194 194 1 1
IL18 LMLN 0 0 183 183 1 1
IL18 DEFB1 0 0 261 261 1 1
IL18 STAT1 0 0 602 614 1 2
IL18 SOCS5 0 0 240 254 1 1
IL18 IL6 0 900 870 988 1 2
IL18 CTRL 0 0 181 181 1 2
IL18 LYZ 0 0 134 211 1 1
IL18 CXCL14 0 0 241 240 1 1
IL18 SCAF11 0 0 381 381 1 1
IL18 MOG 0 0 314 313 1 1
IL18 IGFBP7 0 0 426 426 1 1
IL18 ACAN 0 0 240 239 1 1
IL18 MPO 0 0 561 564 1 2
IL18 IL3RA 0 0 321 321 1 1
IL18 NLRC3 0 0 391 404 1 1
IL18 PIK3C3 0 0 211 211 1 2
IL18 BTLA 0 0 161 161 1 1
IL18 UCP2 0 0 229 245 1 2
IL18 HDAC1 0 0 146 168 1 2
IL18 PRDM1 0 0 252 252 1 1
IL18 RIPK1 0 0 458 457 1 2
IL18 ULBP1 0 0 266 275 1 1
IL18 CSF1 0 0 595 597 1 1
IL18 LTBR 0 0 269 295 1 1
IL18 AHSG 0 0 284 284 1 1
IL18 GPI 0 0 74 173 1 2
IL18 SMPD1 0 0 150 178 1 1
IL18 CEBPB 0 0 294 294 1 2
IL18 FGF9 0 0 101 157 1 1
IL18 ATG16L1 0 0 521 524 1 2
IL18 IL13RA1 0 0 260 265 1 1
IL18 HCK 0 0 144 184 1 1
IL18 DNAJA2 0 0 357 357 1 1
IL18 TSPO 0 0 210 210 1 1
IL18 CIITA 0 0 422 434 1 1
IL18 NOD2 0 0 683 689 1 2
IL18 PIGR 0 0 202 202 1 1
IL18 CHUK 0 0 450 450 1 1
IL18 HPX 0 0 150 181 1 1
IL18 S100A12 0 0 385 392 1 1
IL18 GP5 0 0 134 227 1 1
IL18 NLRP11 0 0 140 152 1 1
IL18 SAMHD1 0 0 212 229 1 1
IL18 IL1RAP 0 0 653 653 1 1
IL18 GPX8 0 0 0 188 1 1
IL18 MRC1 0 0 465 476 1 1
IL18 GSK3B 0 0 170 227 1 2
IL18 ITGAX 0 0 602 615 1 1
IL18 S100B 0 0 288 288 1 1
IL18 SLC11A1 0 0 321 335 1 1
IL18 SOCS2 0 0 244 243 1 1
IL18 CASP4 463 800 455 964 1 2
IL18 CDKN2A 0 0 233 232 1 2
IL18 CXCL16 0 0 391 414 1 1
IL18 ADM 0 0 203 203 1 2
IL18 GUSB 0 0 201 243 1 1
IL18 FABP4 0 0 194 194 1 1
IL18 CXCL5 0 0 469 689 1 1
IL18 CSTB 0 0 150 157 1 1
IL18 PPIA 0 0 171 171 1 1
IL18 VEGFC 0 0 236 236 1 1
IL18 FPR3 0 0 133 159 1 1
IL18 CD5 0 0 290 290 1 1
IL18 CD28 0 0 593 593 1 1
IL18 CYBB 0 0 417 445 1 2
IL18 REN 0 0 390 398 1 1
IL18 ATG12 0 0 298 298 1 2
IL18 RNASE2 0 0 283 299 1 1
IL18 CD1B 0 0 324 335 1 1
IL18 IL13 0 900 760 975 1 2
IL18 TNFRSF10B 0 0 282 292 1 2
IL18 VIL1 0 0 441 454 1 1
IL18 ACE 0 0 395 399 1 1
IL18 CTSS 0 0 180 245 1 1
IL18 ANG 0 0 210 210 1 2
IL18 ALOX5 0 900 325 929 1 1
IL18 TNFSF13B 0 0 470 481 1 1
IL18 PTGS2 0 0 556 574 1 2
IL18 CCL11 0 0 660 687 1 1
IL18 FGF19 0 0 113 238 1 1
IL18 PSMB9 0 0 193 193 1 1
IL18 AICDA 0 0 150 168 1 1
IL18 CASP3 213 0 601 693 1 2
IL18 F3 0 0 364 377 1 1
IL18 NQO1 0 0 195 195 1 2
IL18 SSTR2 0 0 60 160 1 1
IL18 AFP 0 0 167 189 1 2
IL18 PGLYRP1 0 0 170 169 1 1
IL18 FIGF 0 0 261 261 1 1
IL18 MSR1 0 0 214 231 1 1
IL18 IL1RL1 0 0 556 556 1 1
IL18 KIR2DL1 0 0 455 455 1 1
IL18 NLRP3 0 0 908 931 1 2
IL18 REL 0 0 370 370 1 2
IL18 MMP14 0 0 233 242 1 1
IL18 PLA2G7 0 0 234 234 1 1
IL18 CARD16 0 0 194 544 1 1
IL18 ADIRF 298 0 0 298 1 1
IL18 CXCL1 0 900 669 975 1 2
IL18 IL33 0 0 803 816 1 2
IL18 APCS 0 0 193 193 1 1
IL18 HLA-DRA 0 0 180 179 1 1
IL18 IFNA17 0 0 335 335 1 1
IL18 NOD1 0 0 663 676 1 2
IL18 SHARPIN 0 0 167 167 1 1
IL18 MADCAM1 0 0 155 154 1 1
IL18 PGF 0 0 291 290 1 1
IL18 CFB 0 0 212 240 1 1
IL18 SERPINB4 130 0 61 164 1 1
IL18 CD81 0 0 212 221 1 1
IL18 BGN 0 0 203 203 1 1
IL18 P2RY11 0 0 180 179 1 1
IL18 ENSG00000277117 0 0 304 304 1 1
IL18 CD86 0 0 616 636 1 1
IL18 IL18R1 936 900 962 999 1 1
IL18 WARS 0 0 76 168 1 1
IL18 TRAF3 0 0 370 383 1 2
IL18 TOLLIP 0 0 315 315 1 1
IL18 PTGER3 0 0 167 167 1 1
IL18 LRP2 0 0 161 172 1 1
IL18 PMAIP1 0 0 157 156 1 2
IL18 TLR2 0 0 737 756 1 2
IL18 MAPK11 0 0 161 222 1 1
IL18 FGF23 0 0 186 186 1 1
IL18 DUSP1 0 0 218 218 1 1
IL18 SLC5A2 0 0 165 165 1 1
IL18 LRP1 0 0 235 235 1 1
IL18 TLR6 0 0 528 625 1 1
IL18 IL2 0 0 985 985 1 1
IL18 VSIG4 0 0 142 165 1 1
IL18 ANXA1 0 0 256 319 1 1
IL18 ITGA2 0 0 235 343 1 1
IL18 OLR1 0 0 287 286 1 2
IL18 PTGES 0 0 211 211 1 1
IL18 THBS1 0 0 274 274 1 1
IL18 SDC1 0 0 208 208 1 1
IL18 CCL7 0 0 596 616 1 1
IL18 BECN1 0 0 456 456 1 2
IL18 MAPT 0 0 156 155 1 2
IL18 HLA-DPA1 0 0 159 158 1 1
IL18 PTH 0 0 278 278 1 1
IL18 RNASE3 0 0 265 265 1 1
IL18 GPBAR1 0 0 246 245 1 1
IL18 CD3E 0 0 248 287 1 1
IL18 SOD2 0 0 275 275 1 2
IL18 IFNGR1 0 0 406 441 1 1
IL18 HLA-B 0 0 262 262 1 1
IL18 CCL17 0 0 504 504 1 1
IL18 ITGB2 0 0 293 330 1 1
IL18 FOXO1 0 0 229 228 1 2
IL18 KRAS 0 0 186 236 1 2
IL18 PKN2 0 0 148 166 1 1
IL18 CCL8 0 0 382 432 1 1
IL18 CD96 0 0 202 202 1 1
IL18 HSPA5 0 0 218 218 1 2
IL18 CASP14 0 0 167 167 1 1
IL18 PTPN11 0 0 207 207 1 1
IL18 IRAK3 0 0 391 390 1 1
IL18 TNIP1 0 0 171 179 1 1
IL18 SIGIRR 0 0 505 505 1 1
IL18 IFNL3 0 0 370 373 1 1
IL18 FCER1A 0 0 181 202 1 1
IL18 IRG1 0 0 205 228 1 1
IL18 MMP24 0 0 73 195 1 1
IL18 AQP4 0 0 143 178 1 1
IL18 ANGPTL4 0 0 181 181 1 1
IL18 STAT5A 0 0 402 402 1 1
IL18 PON1 0 0 151 274 1 1
IL18 CLDN2 0 0 229 228 1 1
IL18 IL31 0 0 468 468 1 1
IL18 MNDA 0 0 243 299 1 1
IL18 IGSF6 0 0 134 180 1 1
IL18 SOCS3 0 0 456 456 1 1
IL18 CLEC9A 0 0 205 205 1 1
IL18 IL15RA 0 0 277 295 1 1
IL18 FASLG 0 0 560 560 1 1
IL18 FOS 0 0 414 414 1 2
IL18 CCL27 0 0 562 562 1 1
IL18 S100A8 0 0 294 319 1 2
IL18 CMA1 0 0 400 400 1 1
IL18 VAV1 0 0 218 254 1 1
IL18 HSPB1 0 0 170 169 1 2
IL18 NCF2 0 0 194 236 1 1
IL18 ENSG00000255819 0 0 653 677 1 1
IL18 HSPB2 0 0 154 153 1 1
IL18 EPX 0 0 194 194 1 1
IL18 IL22RA1 0 0 324 323 1 1
IL18 GBP3 0 0 159 216 1 1
IL18 TGFBR1 0 0 170 169 1 1
IL18 SOCS6 0 0 211 211 1 1
IL18 SERPINB9 0 0 158 217 1 1
IL18 NFKBIB 0 0 234 281 1 1
IL18 SERPINB8 0 0 58 336 1 1
IL18 HAND2 0 0 0 309 1 1
IL18 ADAM17 0 0 369 369 1 1
IL18 SERPINB5 0 0 57 341 1 1
IL18 MCAM 0 0 167 167 1 1
IL18 ISG15 0 0 324 323 1 2
IL18 CD1E 0 0 302 314 1 1
IL18 XCL1 0 0 380 387 1 1
IL18 MAP1LC3B 0 0 323 341 1 2
IL18 DFFB 0 0 167 167 1 1
IL18 TIMP2 0 0 421 427 1 1
IL18 TBX21 0 0 654 658 1 1
IL18 ULK1 0 0 228 227 1 2
IL18 NCAM1 0 0 601 606 1 1
IL18 PKN1 0 0 181 181 1 1
IL18 MAPKAPK3 0 0 46 306 1 1
IL18 ELANE 0 0 425 424 1 1
IL18 THPO 0 0 241 293 1 1
IL18 PRKCA 0 0 180 179 1 1
IL18 MMP13 0 0 323 323 1 2
IL18 IL5RA 0 0 214 263 1 1
IL18 CXCR5 0 0 314 610 1 1
IL18 C3 0 0 394 408 1 2
IL18 C1QC 0 0 123 185 1 1
IL18 VTN 0 0 150 167 1 1
IL18 KLRC2 0 0 518 518 1 1
IL18 CASR 0 0 181 199 1 2
IL18 FN1 0 0 458 469 1 2
IL18 RAG2 0 0 323 323 1 1
IL18 IKBKG 0 0 420 420 1 1
IL18 CCR7 0 0 518 531 1 1
IL18 CCR9 0 0 369 369 1 1
IL18 GPX1 0 0 158 164 1 1
IL18 SIRT1 0 0 392 400 1 2
IL18 AIRE 0 0 165 185 1 1
IL18 IL10RB 0 0 401 400 1 1
IL18 ERVW-1 0 0 150 151 1 1
IL18 MCL1 0 0 233 256 1 2
IL18 EOMES 0 0 467 467 1 1
IL18 SPI1 0 0 393 420 1 1
IL18 NOX1 0 0 246 262 1 1
IL18 CTSB 0 0 560 563 1 2
IL18 PRL 0 0 210 210 1 1
IL18 CTF1 0 0 184 183 1 1
IL18 CTSK 0 0 251 269 1 2
IL18 LYN 0 0 225 260 1 1
IL18 DFNA5 0 0 370 370 1 1
IL18 ESR1 0 0 250 250 1 2
IL18 IFNB1 0 0 688 693 1 1
IL18 HMGB1 0 0 633 654 1 2
IL18 DUOX2 0 0 234 250 1 1
IL18 IRF5 0 0 396 411 1 1
IL18 MAP3K5 0 0 229 228 1 1
IL18 OPTN 0 0 210 210 1 2
IL18 ACKR2 0 0 403 403 1 1
IL18 BACE1 0 0 176 175 1 2
IL18 SMAD7 0 0 210 210 1 1
IL18 ITGAM 0 0 637 662 1 1
IL18 PDCD1 0 0 372 383 1 2
IL18 P2RY2 0 0 288 314 1 1
IL18 TLR8 0 0 565 584 1 1
IL18 CRH 0 0 269 269 1 1
IL18 ITGB3 0 0 148 166 1 1
IL18 CALCOCO2 0 0 235 235 1 2
IL18 ATG5 0 0 459 459 1 2
IL18 MT-ND1 0 0 0 248 1 1
IL18 NLRP14 0 0 218 400 1 1
IL18 MVK 0 0 217 217 1 1
IL18 EBI3 0 0 142 199 1 1
IL18 SEMA6C 0 0 61 163 1 1
IL18 ELN 0 0 240 239 1 1
IL18 C1QA 0 0 178 235 1 1
IL18 TNFAIP2 0 0 150 181 1 1
IL18 ATP4A 0 0 212 212 1 1
IL18 IRF1 0 0 507 567 1 2
IL18 HLA-C 0 0 324 323 1 1
IL18 STAT2 0 0 369 395 1 1
IL18 CXCR3 0 0 557 558 1 1
IL18 XBP1 0 0 261 261 1 2
IL18 NEK7 0 0 459 459 1 1
IL18 PTEN 0 0 263 263 1 2
IL18 GSDMC 0 0 225 260 1 1
IL18 STX11 0 0 203 222 1 1
IL18 MBP 0 0 229 233 1 2
IL18 IRF4 0 0 390 390 1 1
IL18 FPR1 0 0 242 258 1 1
IL18 IFNA21 0 0 337 337 1 1
IL18 NLRP6 0 0 736 739 1 1
IL18 LRR1 0 0 213 226 1 1
IL18 VEGFA 0 0 654 654 1 2
IL18 BST2 0 0 216 222 1 1
IL18 TNFRSF11A 0 0 143 196 1 1
IL18 FFAR4 0 0 210 210 1 1
IL18 MMP11 0 0 70 172 1 1
IL18 CD200 0 0 234 234 1 1
IL18 PDCD1LG2 0 0 335 349 1 1
IL18 NFATC1 0 0 233 232 1 2
IL18 GAPDHS 0 0 0 207 1 1
IL18 DNM1L 0 0 143 183 1 2
IL18 CASP5 0 0 631 790 1 1
IL18 FCER1G 0 0 273 332 1 1
IL18 ANGPTL2 0 0 171 171 1 1
IL18 SYK 0 0 468 501 1 2
IL18 LEP 0 0 566 577 1 1
IL18 S1PR1 0 0 217 239 1 1
IL18 NFKBIA 0 0 556 565 1 2
IL18 KIT 0 0 364 365 1 2
IL18 SREBF1 0 0 264 264 1 1
IL18 FCGR2A 0 0 403 452 1 1
IL18 CLEC4E 0 0 325 339 1 1
IL18 WDR1 0 0 181 181 1 1
IL18 RORC 0 0 376 385 1 1
IL18 IL21R 0 0 272 302 1 1
IL18 MGEA5 0 0 469 469 1 1
IL18 TNFRSF9 0 0 401 400 1 1
IL18 CD226 0 0 504 504 1 1
IL18 TIMP3 0 0 205 213 1 1
IL18 LRRFIP2 0 0 149 168 1 1
IL18 MAPK14 0 0 335 437 1 2
IL18 IL18RAP 894 900 988 999 1 1
IL18 THBD 0 0 334 350 1 1
IL18 ATM 0 0 194 194 1 2
IL18 SERPINC1 0 0 170 169 1 1
IL18 IGF2 0 0 175 175 1 1
IL18 MARCO 0 0 235 266 1 1
IL18 CTSD 0 0 216 216 1 2
IL18 IL23A 0 0 500 499 1 1
IL18 CTSG 0 0 454 454 1 1
IL18 ENG 0 0 213 213 1 2
IL18 CCL3 0 900 710 972 1 1
IL18 CCL22 0 900 502 948 1 1
IL18 FCGR3B 0 0 561 570 1 1
IL18 GOT2 0 0 469 469 1 1
IL18 LITAF 0 0 206 485 1 1
IL18 HLA-A 0 0 270 270 1 1
IL18 ICAM3 0 0 235 235 1 1
IL18 CMPK2 0 0 157 163 1 1
IL18 GDF15 0 0 183 183 1 1
IL18 HCAR1 0 0 149 167 1 1
IL18 ACTG1 0 0 233 270 1 1
IL18 NR1H4 0 0 273 273 1 1
IL18 CCL23 0 0 261 307 1 1
IL18 TJP1 0 0 294 294 1 1
IL18 SELE 0 0 509 509 1 1
IL18 TGFBR2 0 0 213 213 1 1
IL18 TAC1 0 0 322 321 1 1
IL18 TRAT1 0 0 262 262 1 1
IL18 ATG7 0 0 361 361 1 2
IL18 NAMPT 0 0 373 373 1 2
IL18 FLT3 0 0 276 276 1 2
IL18 IRAK4 0 0 520 534 1 1
IL18 COL1A1 0 0 195 195 1 2
IL18 CXCL2 0 900 561 967 1 1
IL18 CXCR6 0 0 458 457 1 1
IL18 GFAP 0 0 270 300 1 2
IL18 CCL20 0 900 595 957 1 1
IL18 IL10 0 900 858 988 1 2
IL18 ADRB2 0 0 211 229 1 1
IL18 REM1 0 0 0 188 1 1
IL18 AGTR1 0 0 212 212 1 1
IL18 FCGR1A 0 0 373 400 1 1
IL18 RPS6KB1 0 0 189 189 1 2
IL18 AHR 0 0 391 413 1 2
IL18 SERPINE1 0 0 469 470 1 1
IL18 ZBTB32 0 0 261 274 1 1
IL18 SLPI 0 0 208 236 1 1
IL18 HIST2H2BE 0 0 234 253 1 1
IL18 MUC1 0 0 293 293 1 1
IL18 NLRP2 0 0 518 597 1 1
IL18 CD207 0 0 270 270 1 1
IL18 HMGCR 0 0 195 195 1 1
IL18 NTRK1 0 0 162 161 1 1
IL18 KLRG1 0 0 426 426 1 1
IL18 LOX 0 0 245 244 1 2
IL18 GNLY 0 0 289 288 1 1
IL18 IRS1 0 0 286 291 1 2
IL18 ANXA2 0 0 146 212 1 1
IL18 NCF1 0 0 255 271 1 1
IL18 IRAK2 0 0 325 344 1 1
IL18 PTAFR 0 0 124 167 1 1
IL18 MTHFR 0 0 166 165 1 1
IL18 STIM1 0 0 97 190 1 2
IL18 IFIT2 0 0 228 227 1 1
IL18 ICAM2 0 0 206 223 1 1
IL18 CD19 0 0 518 535 1 1
IL18 CSF2RB 0 0 124 178 1 1
IL18 CD274 0 0 505 523 1 2
IL18 SREBF2 0 0 155 154 1 1
IL18 CCND1 0 0 241 240 1 2
IL18 TIMD4 0 0 181 198 1 1
IL18 AIMP1 0 0 113 156 1 1
IL18 ACTA2 0 0 61 154 1 1
IL18 HLA-E 0 0 456 456 1 1
IL18 NOS3 0 0 375 384 1 2
IL18 FLT3LG 0 0 338 348 1 1
IL18 LDLR 0 0 262 262 1 2
IL18 CARD18 0 0 244 243 1 1
IL18 CCL19 0 900 467 944 1 1
IL18 CHIT1 0 0 191 201 1 1
IL18 P2RY6 0 0 203 222 1 1
IL18 CD97 0 0 60 159 1 1
IL18 CTLA4 0 0 634 634 1 2
IL18 RNASEL 0 0 323 332 1 1
IL18 HPRT1 0 0 323 331 1 1
IL18 CD46 0 0 261 261 1 2
IL18 IFI44 0 0 185 257 1 1
IL18 CD38 0 0 347 361 1 2
IL18 PTPN2 0 0 155 154 1 2
IL18 CKLF 0 0 134 188 1 1
IL18 TXN 0 0 391 413 1 1
IL18 LCP1 0 0 54 152 1 1
IL18 S100A10 0 0 81 280 1 1
IL18 NUBP2 0 0 145 184 1 1
IL18 NPHS2 0 0 161 161 1 2
IL18 ENSG00000264813 0 0 392 396 1 1
IL18 FSTL1 0 0 263 263 1 1
IL18 RETNLB 0 0 329 329 1 1
IL18 HGF 0 0 400 400 1 2
IL18 TRAF3IP2 0 0 229 228 1 1
IL18 SFTPD 0 0 260 260 1 1
IL18 SPINK1 0 0 57 220 1 1
IL18 GFI1 0 0 167 174 1 1
IL18 CAT 0 0 424 424 1 2
IL18 PECAM1 0 0 325 325 1 1
IL18 CCL1 0 0 371 371 1 1
IL18 KIR3DL1 0 0 455 455 1 1
IL18 NBR1 0 0 171 192 1 2
IL18 IFITM1 0 0 157 175 1 1
IL18 NCR3LG1 0 0 288 288 1 1
IL18 TNF 0 900 870 988 1 2
IL18 PLA2G2A 0 0 211 211 1 1
IL18 TANK 0 0 282 282 1 2
IL18 XDH 0 0 112 202 1 1
IL18 TIRAP 0 0 504 504 1 1
IL18 HLA-DMA 0 0 149 170 1 1
IL18 MMP25 0 0 89 181 1 1
IL18 CD44 0 0 451 464 1 2
IL18 BDNF 0 0 414 421 1 2
IL18 ITK 0 0 171 171 1 1
IL18 IL7 0 0 739 740 1 1
IL18 ADAMTS4 0 0 167 167 1 1
IL18 KRT14 0 0 150 168 1 1
IL18 NT5E 0 0 294 294 1 1
IL18 IL1RN 0 0 608 664 1 1
IL18 MMP3 0 0 457 468 1 1
IL18 LPIN2 0 0 181 181 1 1
IL18 HDC 0 0 182 181 1 1
IL18 CASP2 0 0 291 290 1 1
IL18 CHIA 0 0 120 180 1 1
IL18 VDR 0 0 272 290 1 2
IL18 NAIP 0 0 596 604 1 1
IL18 CD300LF 0 0 127 158 1 1
IL18 MMP7 0 0 310 342 1 1
IL18 CD209 0 0 419 418 1 1
IL18 NFAT5 0 0 140 230 1 1
IL18 DFNB59 0 0 150 173 1 1
IL18 RBFOX3 0 0 234 238 1 1
IL18 IL23R 0 0 494 493 1 1
IL18 POU2F1 0 0 322 321 1 1
IL18 ENSG00000272980 0 0 503 524 1 1
IL18 TFRC 0 0 231 230 1 1
IL18 TNFAIP6 0 0 195 195 1 1
IL18 IFNAR1 0 0 503 506 1 1
IL18 IL5 0 0 739 742 1 1
IL18 VWF 0 0 341 341 1 1
IL18 CD63 0 0 193 202 1 2
IL18 AGT 0 0 260 321 1 1
IL18 CD70 0 0 273 273 1 1
IL18 IL1R2 0 0 505 517 1 1
IL18 ATP12A 0 0 217 217 1 1
IL18 SPN 0 0 184 183 1 1
IL18 CMKLR1 0 0 217 217 1 1
IL18 GCG 0 0 288 288 1 1
IL18 TNFAIP3 0 0 373 388 1 2
IL18 NFKB2 0 900 271 924 1 1
IL18 APOC3 0 0 157 165 1 1
IL18 IL34 0 0 269 269 1 1
IL18 ENSG00000196136 0 0 204 233 1 1
IL18 RELB 0 0 325 336 1 2
IL18 S100A9 0 0 246 283 1 1
IL18 CD9 0 0 181 190 1 1
IL18 FGF2 0 0 459 462 1 2
IL18 CXCL3 0 0 325 523 1 1
IL18 RAB7A 0 0 161 161 1 2
IL18 TIGIT 0 0 321 321 1 1
IL18 IFNL2 0 0 294 298 1 1
IL18 TXNIP 0 0 622 622 1 2
IL18 TNFSF14 0 0 287 286 1 1
IL18 MMP8 0 0 367 391 1 1
IL18 BCL2A1 0 0 184 204 1 1
IL18 IFI16 0 0 560 582 1 1
IL18 IFNL1 0 0 342 346 1 1
IL18 FFAR3 0 0 269 269 1 1
IL18 ATF3 0 0 253 252 1 2
IL18 CDH5 0 0 150 172 1 1
IL18 GBP5 0 0 371 371 1 1
IL18 RETN 0 0 504 504 1 1
IL18 APOB 0 0 297 297 1 2
IL18 CSF1R 0 0 325 356 1 1
IL18 DEFB4A 0 0 391 390 1 1
IL18 MMP27 0 0 52 224 1 1
IL18 DDX53 0 0 282 282 1 1
IL18 SOCS4 0 0 205 205 1 1
IL18 IRF7 0 0 508 528 1 1
IL18 MAPK1 0 0 171 181 1 2
IL18 IGF1 0 0 401 415 1 2
IL18 ITIH4 0 0 282 292 1 1
IL18 SOCS1 0 0 423 422 1 1
IL18 FABP1 0 0 634 634 1 1
IL18 BTK 0 0 219 219 1 1
IL18 ULBP2 0 0 218 227 1 1
IL18 MERTK 0 0 204 221 1 1
IL18 ITPKC 0 0 181 181 1 1
IL18 IL11 0 0 556 556 1 1
IL18 ID2 0 0 285 284 1 1
IL18 GPT 0 0 463 463 1 1
IL18 CD58 0 0 231 230 1 1
IL18 SIRT4 0 0 209 209 1 1
IL18 GJA1 0 0 211 211 1 1
IL18 CCK 0 0 125 185 1 1
IL18 BCL6 0 0 261 272 1 1
IL18 PINK1 0 0 212 212 1 2
IL18 IFNGR2 0 0 293 293 1 1
IL18 IL24 0 0 325 325 1 2
IL18 AXL 0 0 181 198 1 2
IL18 HSP90AB1 0 0 92 180 1 2
IL18 MALT1 0 0 232 231 1 1
IL18 CXCL10 0 900 731 973 1 2
IL18 KRT18 0 0 173 173 1 1
IL18 CYLD 0 0 210 210 1 1
IL18 EDNRB 0 0 112 170 1 1
IL18 PYCARD 0 800 759 956 1 2
IL18 IL6ST 0 0 285 284 1 1
IL18 LTB4R 0 0 219 219 1 1
IL18 TNFSF8 0 0 218 218 1 1
IL18 NR1I2 0 0 151 150 1 1
IL18 VLDLR 0 0 321 321 1 1
IL18 KIR2DL4 0 0 346 345 1 1
IL18 CD1D 0 0 561 568 1 1
IL18 CFP 0 0 170 169 1 1
IL18 GZMK 0 0 213 230 1 1
IL18 TLR9 0 0 701 721 1 2
IL18 CR2 0 0 181 181 1 1
IL18 IRF3 0 0 601 601 1 2
IL18 NGF 0 0 455 455 1 2
IL18 CD34 0 0 391 390 1 2
IL18 ERBB2 0 0 285 284 1 2
IL18 ARG2 0 0 383 387 1 1
IL18 MEP1B 0 0 92 155 1 1
IL18 CCL3L3 0 900 171 921 1 1
IL18 NLRP7 0 0 557 629 1 1
IL18 KLK4 0 0 193 193 1 1
IL18 CTSC 0 0 169 187 1 1
IL18 IL17RB 0 0 324 323 1 1
IL18 PPARG 0 0 460 471 1 2
IL18 AKT1 0 0 519 538 1 2
IL18 GBP2 0 0 292 338 1 1
IL18 TGFB2 0 0 381 381 1 1
IL18 ACKR1 0 0 167 167 1 1
IL18 IL17C 0 0 314 313 1 1
IL18 CD48 0 0 268 268 1 1
IL18 MKI67 0 0 74 215 1 2
IL18 IL12RB1 0 0 625 625 1 1
IL18 CSF2 0 900 746 973 1 1
IL18 LY96 0 0 458 471 1 1
IL18 FAS 0 0 391 441 1 2
IL18 CARD8 0 0 504 504 1 1
IL18 VCAM1 0 0 602 610 1 1
IL18 IFIT3 0 0 206 223 1 1
IL18 CCL16 0 0 172 171 1 1
IL18 CCL14 0 0 203 231 1 1
IL18 CD4 0 0 766 795 1 2
IL18 INPP5D 0 0 181 181 1 1
IL18 ATP7A 0 0 212 212 1 1
IL18 CD247 0 0 391 398 1 1
IL18 VIP 0 0 182 181 1 1
IL18 PANX1 0 0 522 533 1 1
IL18 DUOX1 0 0 230 246 1 1
IL18 KLF4 0 0 181 201 1 2
IL18 ATF6 0 0 206 206 1 2
IL18 ALOX5AP 0 0 157 162 1 1
IL18 IKBKB 0 0 469 470 1 2
IL18 NLRC4 0 0 856 868 1 2
IL18 CST3 0 0 681 681 1 1
IL18 NOX4 0 0 310 319 1 2
IL18 KIR2DL3 0 0 459 459 1 1
IL18 CLEC4C 0 0 258 258 1 1
IL18 CFH 0 0 294 294 1 1
IL18 FABP2 0 0 211 211 1 1
IL18 IFNLR1 0 0 202 287 1 1
IL18 RUNX2 0 0 181 181 1 2
IL18 XIAP 0 0 324 331 1 2
IL18 SERPINB6 0 0 70 213 1 1
IL18 FOXP3 0 0 607 609 1 2
IL18 HMOX1 0 0 456 456 1 2
IL18 IL32 0 0 519 519 1 1
IL18 HLA-DOB 0 0 95 157 1 1
IL18 PPBP 0 0 310 437 1 1
IL18 TBK1 0 0 460 460 1 2
IL18 TICAM2 0 0 157 228 1 1
IL18 NCR2 0 0 526 526 1 1
IL18 ADIPOR2 0 0 207 207 1 1
IL18 CLEC5A 0 0 217 239 1 1
IL18 P2RX1 0 0 277 277 1 1
IL18 RAC2 0 0 154 193 1 1
IL18 LYST 0 0 165 165 1 1
IL18 KLRB1 0 0 503 506 1 1
IL18 NFATC2 0 0 217 217 1 1
IL18 STXBP2 0 0 167 187 1 1
IL18 KDR 0 0 261 277 1 2
IL18 RARRES2 0 0 322 336 1 1
IL18 IL4I1 0 0 113 155 1 1
IL18 JAK1 0 0 419 418 1 2
IL18 ICOS 0 0 207 208 1 1
IL18 CLDN4 0 0 138 157 1 1
IL18 EIF2S1 0 0 181 181 1 2
IL18 ANPEP 0 0 150 170 1 1
IL18 NTN1 0 0 206 206 1 1
IL18 MMP12 0 0 338 352 1 1
IL18 SCGB1A1 0 0 150 173 1 1
IL18 F2R 0 0 151 150 1 1
IL18 GHITM 0 0 95 176 1 1
IL18 ENSG00000244255 0 0 142 173 1 1
IL18 PF4 0 0 320 362 1 1
IL18 C1QB 0 0 181 200 1 1
IL18 ADORA2B 0 0 262 262 1 1
IL18 BNIP3L 0 0 143 169 1 2
IL18 KRT19 0 0 112 174 1 1
IL18 VDAC1 0 0 218 218 1 2
IL18 GADD45G 0 0 163 163 1 1
IL18 TGFB1 0 0 413 493 1 2
IL18 STAT5B 0 0 402 402 1 1
IL18 RAB7B 0 0 166 165 1 1
IL18 RIPK3 0 0 457 472 1 2
IL18 MMP10 0 0 207 261 1 1
IL18 IFIT1 0 0 283 282 1 1
IL18 REG3A 0 0 254 274 1 1
IL18 CD2 0 0 324 323 1 1
IL18 PRKCD 0 0 254 254 1 2
IL18 TRPV4 0 0 95 157 1 1
IL18 TEP1 0 0 156 155 1 1
IL18 TXLNA 0 0 282 282 1 1
IL18 BGLAP 0 0 164 163 1 1
IL18 CD47 0 0 267 283 1 2
IL18 SPTAN1 0 0 193 193 1 1
IL18 TNFSF11 0 0 469 469 1 2
IL18 IL25 0 0 310 309 1 1
IL18 MB 0 0 240 239 1 2
IL18 BPI 0 0 150 177 1 1
IL18 SLC2A4 0 0 252 256 1 1
IL18 IL26 0 0 340 340 1 1
IL18 IL36B 0 0 402 557 1 1
IL18 FOXO3 0 0 243 244 1 2
IL18 APOE 0 0 507 518 1 2
IL18 SCD 0 0 137 155 1 1
IL18 IRF8 0 0 372 385 1 1
IL18 HP 0 0 391 404 1 1
IL18 CD3G 0 0 181 181 1 1
IL18 SRC 0 0 374 387 1 2
IL18 ADA 0 0 222 239 1 1
IL18 F2 0 0 216 251 1 1
IL18 RAG1 0 0 325 325 1 1
IL18 CDC42 0 0 212 218 1 2
IL18 ATG3 0 0 183 183 1 2
IL18 LGALS3 0 0 335 377 1 2
IL18 MIF 0 0 556 556 1 2
IL18 TLR3 0 0 681 705 1 2
IL18 IL19 0 0 400 400 1 1
IL18 RSAD2 0 0 293 339 1 1
IL18 TNFRSF18 0 0 248 248 1 1
IL18 FLT1 0 0 234 234 1 1
IL18 CD52 0 0 174 173 1 1
IL18 CADM1 0 0 216 227 1 1
IL18 FAM110A 0 0 0 189 1 1
IL18 A2M 0 0 241 293 1 1
IL18 CCR8 0 0 261 261 1 1
IL18 EIF2AK3 0 0 261 261 1 2
IL18 SERPINB7 0 0 0 309 1 1
IL18 SERPINB3 0 0 44 218 1 1
IL18 TNFSF12 0 0 329 329 1 1
IL18 P2RY13 0 0 112 150 1 1
IL18 STAT6 0 0 504 504 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005125 Molecular Function cytokine activity enables IDA
GO:0005125 Molecular Function cytokine activity enables ISS
GO:0005125 Molecular Function cytokine activity enables TAS
GO:0045515 Molecular Function interleukin-18 receptor binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0042088 Biological Process T-helper 1 type immune response involved_in IDA
GO:0001525 Biological Process angiogenesis involved_in IDA
GO:0008283 Biological Process cell population proliferation involved_in IEA
GO:0007267 Biological Process cell-cell signaling involved_in TAS
GO:0042632 Biological Process cholesterol homeostasis involved_in ISS
GO:0050830 Biological Process defense response to Gram-positive bacterium involved_in ISS
GO:0061436 Biological Process establishment of skin barrier involved_in ISS
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0035655 Biological Process interleukin-18-mediated signaling pathway involved_in IDA
GO:0030101 Biological Process natural killer cell activation involved_in IEA
GO:0042267 Biological Process natural killer cell mediated cytotoxicity involved_in IEA
GO:0045662 Biological Process negative regulation of myoblast differentiation involved_in IEA
GO:0042119 Biological Process neutrophil activation involved_in IEA
GO:0038061 Biological Process non-canonical NF-kappaB signal transduction involved_in IEA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0051142 Biological Process positive regulation of NK T cell proliferation involved_in IDA
GO:2000556 Biological Process positive regulation of T-helper 1 cell cytokine production involved_in IDA
GO:0045630 Biological Process positive regulation of T-helper 2 cell differentiation involved_in ISS
GO:0042104 Biological Process positive regulation of activated T cell proliferation involved_in IDA
GO:0032722 Biological Process positive regulation of chemokine production involved_in TAS
GO:0120162 Biological Process positive regulation of cold-induced thermogenesis involved_in ISS
GO:0032725 Biological Process positive regulation of granulocyte macrophage colony-stimulating factor production involved_in IDA
GO:0050729 Biological Process positive regulation of inflammatory response involved_in IC
GO:0050729 Biological Process positive regulation of inflammatory response involved_in ISS
GO:0032736 Biological Process positive regulation of interleukin-13 production involved_in TAS
GO:0032740 Biological Process positive regulation of interleukin-17 production involved_in IDA
GO:0010744 Biological Process positive regulation of macrophage derived foam cell differentiation involved_in ISS
GO:0032819 Biological Process positive regulation of natural killer cell proliferation involved_in IDA
GO:0150078 Biological Process positive regulation of neuroinflammatory response involved_in TAS
GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IEA
GO:0051897 Biological Process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IDA
GO:0048661 Biological Process positive regulation of smooth muscle cell proliferation involved_in IDA
GO:0034105 Biological Process positive regulation of tissue remodeling involved_in IC
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0032729 Biological Process positive regulation of type II interferon production involved_in IDA
GO:0032729 Biological Process positive regulation of type II interferon production involved_in TAS
GO:0042531 Biological Process positive regulation of tyrosine phosphorylation of STAT protein involved_in IDA
GO:0030155 Biological Process regulation of cell adhesion involved_in IDA
GO:0030431 Biological Process sleep involved_in ISS
GO:0070328 Biological Process triglyceride homeostasis involved_in ISS
GO:0042092 Biological Process type 2 immune response involved_in TAS
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IDA
GO:0005615 Cellular Component extracellular space located_in IDA
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Disease Reactome R-HSA-1643685
Immune System Reactome R-HSA-168256
Interleukin-1 family signaling Reactome R-HSA-446652
Interleukin-1 processing Reactome R-HSA-448706
Signaling by Interleukins Reactome R-HSA-449147
Regulated Necrosis Reactome R-HSA-5218859
Programmed Cell Death Reactome R-HSA-5357801
Pyroptosis Reactome R-HSA-5620971
Infectious disease Reactome R-HSA-5663205
Interleukin-10 signaling Reactome R-HSA-6783783
Interleukin-4 and Interleukin-13 signaling Reactome R-HSA-6785807
Interleukin-18 signaling Reactome R-HSA-9012546
Leishmania infection Reactome R-HSA-9658195
Purinergic signaling in leishmaniasis infection Reactome R-HSA-9660826
Cell recruitment (pro-inflammatory response) Reactome R-HSA-9664424
Parasitic Infection Pathways Reactome R-HSA-9824443
Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
Development and heterogeneity of the ILC family (WP3893) WikiPathways WP3893_r118859
Inflammatory bowel disease signaling (WP5198) WikiPathways WP5198_r123858
Overview of proinflammatory and profibrotic mediators (WP5095) WikiPathways WP5095_r120801
Corticotropin-releasing hormone signaling pathway (WP2355) WikiPathways WP2355_r120664
TYROBP causal network in microglia (WP3945) WikiPathways WP3945_r116679
IL-18 signaling pathway (WP4754) WikiPathways WP4754_r115147
Sleep regulation (WP3591) WikiPathways WP3591_r88424
SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction (WP5183) WikiPathways WP5183_r124655
Hypertrophy model (WP516) WikiPathways WP516_r117755
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
IL1 and megakaryocytes in obesity (WP2865) WikiPathways WP2865_r123108
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001243211 2 mRNA transcript variant 2 NC_000011 Reference
NM_001562 4 mRNA transcript variant 1 NC_000011 Reference
XM_011542805 2 mRNA transcript variant X1 NC_000011 Reference
NM_001386420 1 mRNA transcript variant 3 NC_000011 Reference