HAdb 2.0 is available now!

IRF3

interferon regulatory factor 3
General Information
Name interferon regulatory factor 3
Alias
  • interferon regulatory factor 3
Gene_family Interferon regulatory factors
organism Homo sapiens
entrez_id 3661
location 19q13.33
transcript_count 23
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
    Stringdb Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive [...]
    nextProt Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:24049179, PubMed:31340999). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
IRF3 BioGRID TBK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-fractionation; Reconstituted Complex; Two-hybrid
IRF3 BioGRID KPNA2 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID KPNA6 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID ORF1ab GeneID BioGRID Two-hybrid
IRF3 BioGRID ORF8b GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID HDAC2 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID NBR1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID CALCOCO2 GeneID BioGRID Affinity Capture-Western; Co-localization
IRF3 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IRF3 BioGRID CASP8 GeneID BioGRID Co-fractionation
IRF3 BioGRID MOCOS GeneID BioGRID Affinity Capture-MS; Co-fractionation
IRF3 BioGRID NUDT5 GeneID BioGRID Co-fractionation
IRF3 BioGRID IRF3 GeneID BioGRID Affinity Capture-Western; PCA; Reconstituted Complex
IRF3 BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID OTUD7B GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID MAP4K1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID OTULIN GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID UBA1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID PSMB7 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID MID1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID FLOT2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID FLOT1 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID IKBKE GeneID BioGRID Affinity Capture-Western; Biochemical Activity
IRF3 BioGRID CREBBP GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex
IRF3 BioGRID TELO2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID PSEN2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID MSRA GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID C5orf34 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID LRWD1 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID FOXO1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID CSNK1G3 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID AXL GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID ATP1A3 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID ANKRD40 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID CCDC47 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID TMEM132A GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID MOCS3 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID JMJD6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
IRF3 BioGRID GLMN GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID USP19 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID UFL1 GeneID BioGRID Two-hybrid
IRF3 BioGRID STING1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID OGT GeneID BioGRID Reconstituted Complex
IRF3 BioGRID PSMD14 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
IRF3 BioGRID ORF1ab GeneID BioGRID Biochemical Activity
IRF3 BioGRID OTUD1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization
IRF3 BioGRID FADD GeneID BioGRID Negative Genetic
IRF3 BioGRID RALB GeneID BioGRID Positive Genetic
IRF3 BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-RNA
IRF3 BioGRID S1PR1 GeneID BioGRID Negative Genetic
IRF3 BioGRID TRIM63 GeneID BioGRID Two-hybrid
IRF3 BioGRID TRIM55 GeneID BioGRID Two-hybrid
IRF3 BioGRID E6 GeneID BioGRID PCA
IRF3 BioGRID E6 GeneID BioGRID PCA; Two-hybrid
IRF3 BioGRID E6 GeneID BioGRID PCA
IRF3 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western; Biochemical Activity
IRF3 BioGRID FBXO6 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID UBE3A GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID PINK1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID YAP1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID APEX1 GeneID BioGRID Affinity Capture-RNA
IRF3 BioGRID MAP3K14 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID SOCS1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
IRF3 BioGRID FKBP8 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID ZC3H12A GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID WDR82 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID FBXO7 GeneID BioGRID Biochemical Activity
IRF3 BioGRID FBXO17 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID PPP2CA GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
IRF3 BioGRID DOCK7 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID CCDC88A GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID CBL GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID DDX3X GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID MAVS GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
IRF3 BioGRID TRIM26 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
IRF3 BioGRID IPO5 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID ESYT2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID WRNIP1 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID BCAS3 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID ADGRL2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID SMC2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID SYNGR3 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID ASMTL GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID SMC1A GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID SLMAP GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID TRO GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID SALL2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID SORT1 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID PSMA5 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID TEX36 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID TUBB8 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID KIT GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID HK2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID FASN GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID DCTN1 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID Mavs GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TICAM1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID HERC5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
IRF3 BioGRID EP300 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Protein-peptide; Reconstituted Complex
IRF3 BioGRID TRAF3IP2 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID POLR2A GeneID BioGRID Co-localization
IRF3 BioGRID DEAF1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID MAFB GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID vIRF-3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
IRF3 BioGRID SMAD4 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID SMAD2 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID vIRF-1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID SGTA GeneID BioGRID Affinity Capture-Western; Two-hybrid
IRF3 BioGRID PEX19 GeneID BioGRID Two-hybrid
IRF3 BioGRID PIAS4 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TOMM70 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
IRF3 BioGRID TLR2 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID MAPK9 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID MAPK8 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
IRF3 BioGRID RIGI GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID TRIM21 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
IRF3 BioGRID PIN1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID IRF7 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
IRF3 BioGRID CUL1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID XIAP GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID HDAC3 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID RBL2 GeneID BioGRID Affinity Capture-MS
IRF3 BioGRID RBL1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
IRF3 BioGRID RB1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
IRF3 BioGRID EWSR1 GeneID BioGRID Two-hybrid
IRF3 Protein GRIP1 GeneID HPRD
IRF3 Protein TICAM2 GeneID HPRD
IRF3 Protein MAVS GeneID HPRD
IRF3 Protein PIAS4 GeneID HPRD
IRF3 Protein SMURF2 GeneID HPRD
IRF3 Protein TICAM1 GeneID HPRD
IRF3 Protein IRF5 GeneID HPRD
IRF3 Protein IKBKE GeneID HPRD
IRF3 Protein IRF7 GeneID HPRD
IRF3 Protein TBK1 GeneID HPRD
IRF3 Protein IRF3 GeneID HPRD
IRF3 Protein EP300 GeneID HPRD
IRF3 Protein CREBBP GeneID HPRD
IRF3 Protein SYT1 GeneID HPRD
IRF3 Protein PRDX1 GeneID HPRD
IRF3 Protein SERPINB2 GeneID HPRD
IRF3 Protein RELA GeneID HPRD
IRF3 Protein PPIB GeneID HPRD
IRF3 BioGRID TANK GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID PPIP5K1 GeneID BioGRID Affinity Capture-Western
IRF3 BioGRID IRF5 GeneID BioGRID Reconstituted Complex
IRF3 BioGRID PRDX1 GeneID BioGRID Two-hybrid
IRF3 Protein IRF3 GeneID BIND IRF-3 dimerizes upon activation.
IRF3 Protein CDKL2 GeneID BIND IRF-3 interacts with the P56 promoter.
IRF3 Protein CREBBP GeneID BIND IRF-3 interacts with CBP.
IRF3 Protein E6 GeneID BIND Human papillomavirus type 16 (HPV16) protein E6 interacts with human host protein IRF-3.
IRF3 Protein CXCL10 GeneID BIND IRF3 interacts with promoter IP-10.
StringDB
A B experiments database textmining combined score hadb nhadb
IRF3 OAS3 0 900 454 944 1 1
IRF3 SMAD4 270 0 386 536 1 2
IRF3 HDAC3 270 0 112 324 1 2
IRF3 PRSS57 0 0 400 400 1 1
IRF3 UBA1 0 0 150 206 1 1
IRF3 CASP10 0 0 244 243 1 1
IRF3 DRG2 0 0 0 150 1 1
IRF3 UBD 0 0 205 205 1 1
IRF3 NELFCD 0 0 184 183 1 1
IRF3 TAX1BP1 0 0 392 392 1 2
IRF3 TLR1 0 0 612 612 1 1
IRF3 EIF2B5 0 0 0 381 1 1
IRF3 PSMB3 0 0 0 214 1 1
IRF3 RBCK1 0 0 521 539 1 1
IRF3 OASL 0 900 518 949 1 1
IRF3 FURIN 0 0 194 194 1 1
IRF3 NFX1 0 0 135 153 1 1
IRF3 PSMA6 0 0 0 183 1 1
IRF3 CD80 0 0 460 459 1 2
IRF3 CCL21 0 0 162 161 1 1
IRF3 FKBP7 0 0 247 256 1 1
IRF3 NLRP12 0 0 246 245 1 1
IRF3 BRCA1 0 0 212 212 1 2
IRF3 PITX1 0 0 96 150 1 1
IRF3 IFITM2 0 900 310 929 1 1
IRF3 CH25H 0 0 240 239 1 1
IRF3 MAP3K8 0 0 243 242 1 1
IRF3 MAP2K1 0 0 184 183 1 1
IRF3 DHX58 0 0 735 746 1 1
IRF3 TCF3 0 0 390 390 1 1
IRF3 IRGM 0 0 234 234 1 2
IRF3 IL15 0 0 475 475 1 1
IRF3 ITGAE 0 0 260 260 1 1
IRF3 MYC 0 0 456 456 1 2
IRF3 MRPS11 0 0 50 246 1 1
IRF3 RNF125 0 0 505 516 1 1
IRF3 IFITM3 0 900 534 952 1 1
IRF3 IL1R1 0 0 562 562 1 1
IRF3 IL18 0 0 601 601 1 2
IRF3 PARP12 0 0 155 173 1 1
IRF3 TRAPPC9 0 0 0 230 1 1
IRF3 IFNA1 0 600 856 940 1 1
IRF3 PPIP5K1 270 0 412 552 1 1
IRF3 PARK2 0 0 158 157 1 1
IRF3 SDHC 0 0 378 411 1 1
IRF3 AZI2 0 0 402 402 1 1
IRF3 USF1 0 0 143 161 1 1
IRF3 TAB2 0 0 503 506 1 2
IRF3 UBE2D1 0 0 233 235 1 1
IRF3 MX1 0 900 700 968 1 1
IRF3 TRAF2 270 0 324 505 1 2
IRF3 TAB1 0 0 459 471 1 1
IRF3 MEFV 0 0 556 562 1 1
IRF3 DHX33 0 0 294 312 1 1
IRF3 MSRA 234 0 0 234 1 1
IRF3 USP15 0 0 244 262 1 1
IRF3 SERPINA5 0 0 155 154 1 1
IRF3 POLR3B 0 0 75 158 1 1
IRF3 JAK2 0 0 341 351 1 2
IRF3 NLRC5 0 0 391 390 1 1
IRF3 TRIM6-TRIM34 0 0 134 275 1 1
IRF3 PTX3 0 0 386 386 1 1
IRF3 APAF1 0 0 170 169 1 2
IRF3 HDAC6 0 0 212 212 1 2
IRF3 EXOC2 0 0 398 398 1 1
IRF3 SKIV2L 0 0 140 168 1 1
IRF3 SRSF1 0 0 195 210 1 1
IRF3 PIN1 270 800 866 979 1 1
IRF3 BRD4 0 0 150 331 1 2
IRF3 MED23 0 0 142 201 1 1
IRF3 RALBP1 0 0 73 216 1 1
IRF3 BAZ2A 0 0 0 242 1 1
IRF3 ERN1 0 0 232 244 1 2
IRF3 TRIM23 0 0 337 345 1 1
IRF3 MICA 0 0 172 217 1 1
IRF3 XRCC6 0 900 284 926 1 1
IRF3 TCEA1 0 0 357 375 1 1
IRF3 GATA3 0 0 181 181 1 1
IRF3 PTPN22 0 0 179 179 1 1
IRF3 AGO2 0 0 150 179 1 2
IRF3 EIF2AK4 0 0 150 151 1 2
IRF3 CD55 0 0 159 158 1 1
IRF3 CD300C 0 0 166 165 1 1
IRF3 TRIM8 0 0 216 228 1 1
IRF3 GMPPA 0 0 0 240 1 1
IRF3 IFNA2 0 900 601 958 1 1
IRF3 DEAF1 270 0 372 522 1 1
IRF3 STAT3 0 0 517 523 1 2
IRF3 IRF9 0 900 768 932 1 1
IRF3 TRIM16 0 0 171 206 1 2
IRF3 MDM2 0 0 193 193 1 2
IRF3 TP53 0 0 571 577 1 2
IRF3 KPNA4 0 0 490 514 1 1
IRF3 TRIM24 0 0 249 272 1 1
IRF3 ZNF143 0 0 163 197 1 1
IRF3 NEDD8 0 0 194 228 1 2
IRF3 VPS53 0 0 0 409 1 1
IRF3 TSLP 0 0 266 266 1 1
IRF3 FBXO6 270 0 0 270 1 1
IRF3 LAMP1 0 0 246 245 1 2
IRF3 ESX1 0 0 394 394 1 1
IRF3 FADD 189 0 517 636 1 2
IRF3 RNASEH2A 0 0 264 264 1 1
IRF3 SARM1 0 0 543 546 1 1
IRF3 TNFRSF4 0 0 150 161 1 1
IRF3 DEFB103A 0 0 161 161 1 1
IRF3 MYD88 0 0 856 882 1 2
IRF3 PPP1CC 0 0 158 157 1 1
IRF3 CFLAR 0 0 324 323 1 2
IRF3 EGFR 0 0 253 252 1 2
IRF3 EXO1 0 0 218 218 1 1
IRF3 LMNA 0 0 261 261 1 2
IRF3 IRAK1 0 0 703 707 1 1
IRF3 CSF3 0 0 286 286 1 1
IRF3 CAMP 0 0 286 286 1 2
IRF3 LSM14A 0 0 215 253 1 1
IRF3 TRAF1 0 0 391 409 1 1
IRF3 MED8 0 0 170 204 1 1
IRF3 CUL2 0 0 354 369 1 1
IRF3 CARD9 0 800 371 871 1 1
IRF3 RBL1 157 0 90 200 1 1
IRF3 MYL6 0 0 0 193 1 1
IRF3 GUK1 0 0 0 215 1 1
IRF3 TRIM40 0 0 173 185 1 1
IRF3 NLRP4 0 600 299 707 1 1
IRF3 DDIT3 0 0 161 161 1 2
IRF3 NUP153 0 0 142 166 1 1
IRF3 MAP3K7 0 0 413 422 1 2
IRF3 KPNA3 0 0 664 664 1 1
IRF3 NFKBIZ 0 0 166 165 1 1
IRF3 SPECC1 0 0 342 342 1 1
IRF3 PABPC1 0 0 150 160 1 1
IRF3 ZBP1 0 800 695 948 1 1
IRF3 CXCR4 0 0 260 260 1 2
IRF3 PEX19 111 0 450 513 1 1
IRF3 HLA-G 0 900 61 902 1 1
IRF3 RRAS 0 0 385 384 1 1
IRF3 TRAF4 0 0 310 331 1 1
IRF3 CD40LG 0 0 325 325 1 1
IRF3 SEC61A1 0 0 242 241 1 1
IRF3 GRIP1 270 0 0 283 1 1
IRF3 RNF138 0 0 70 172 1 1
IRF3 NOTCH1 0 0 184 183 1 2
IRF3 PSMB4 0 0 53 192 1 1
IRF3 RAD23A 0 0 0 158 1 1
IRF3 RPL13A 0 0 103 265 1 1
IRF3 TRIM59 0 0 143 156 1 1
IRF3 NLRP1 0 0 391 390 1 1
IRF3 MTOR 0 0 253 252 1 2
IRF3 APOBEC3G 0 0 392 412 1 1
IRF3 ADAR 0 900 467 944 1 1
IRF3 CD163 0 0 261 261 1 1
IRF3 POTEF 0 0 170 169 1 1
IRF3 KPNA1 0 0 272 275 1 1
IRF3 DDX21 0 0 390 390 1 1
IRF3 PIK3C3 0 0 224 238 1 2
IRF3 MPO 0 0 193 193 1 2
IRF3 NLRC3 0 900 360 933 1 1
IRF3 IL3RA 0 0 167 167 1 1
IRF3 ETS2 0 0 156 155 1 1
IRF3 IL6 0 0 702 713 1 2
IRF3 SCAF11 0 0 48 180 1 1
IRF3 ATL1 0 0 161 161 1 1
IRF3 CTRL 0 0 221 221 1 2
IRF3 SOCS5 0 0 182 181 1 1
IRF3 BRD2 0 0 70 265 1 1
IRF3 STAT1 0 900 803 979 1 2
IRF3 OCLN 0 0 211 228 1 1
IRF3 GZMB 0 0 287 286 1 1
IRF3 TNFRSF1A 0 0 502 512 1 1
IRF3 MYL6B 0 0 0 193 1 1
IRF3 TRIM27 0 0 340 350 1 1
IRF3 NEDD4 0 0 181 181 1 2
IRF3 TRAF5 0 0 467 483 1 1
IRF3 HIF1A 0 0 322 322 1 2
IRF3 OAS1 0 900 610 959 1 1
IRF3 IL1B 0 0 684 692 1 2
IRF3 RAB5A 0 0 164 175 1 2
IRF3 SP1 0 0 151 161 1 2
IRF3 ADAP2 0 0 108 163 1 1
IRF3 CXCL8 0 0 603 603 1 2
IRF3 RNF11 0 0 211 211 1 1
IRF3 SUMO2 0 0 240 239 1 1
IRF3 IL6R 0 0 193 193 1 1
IRF3 NFKBID 0 0 203 203 1 1
IRF3 PAX2 0 0 0 213 1 1
IRF3 NCR1 0 0 167 167 1 1
IRF3 C9orf142 0 0 0 175 1 1
IRF3 SOCS7 0 0 203 203 1 1
IRF3 FCGR3A 0 0 268 268 1 1
IRF3 HRAS 0 0 202 202 1 2
IRF3 CTNNB1 0 600 968 986 1 2
IRF3 TRIM13 0 0 167 180 1 1
IRF3 EGR1 0 900 241 920 1 2
IRF3 IFNA4 0 900 519 950 1 1
IRF3 APP 0 0 161 161 1 2
IRF3 MFN2 0 0 235 253 1 2
IRF3 MYOM2 0 0 391 390 1 1
IRF3 TRIM4 0 0 295 316 1 1
IRF3 CXCR2 0 0 193 193 1 1
IRF3 BAZ1A 0 0 0 242 1 1
IRF3 HERC5 270 900 424 954 1 1
IRF3 XPO1 0 0 252 311 1 1
IRF3 IKBKE 875 800 681 991 1 1
IRF3 TNFRSF1B 0 0 185 185 1 1
IRF3 TRIM25 0 600 738 892 1 1
IRF3 TRIM34 0 0 134 185 1 1
IRF3 TAB3 0 0 415 414 1 1
IRF3 STAT4 0 0 241 251 1 1
IRF3 ZAP70 0 0 139 196 1 1
IRF3 TLR10 0 0 459 459 1 1
IRF3 CLEC7A 0 0 391 390 1 1
IRF3 HMGB2 0 0 413 412 1 1
IRF3 NFKB1 0 0 392 441 1 2
IRF3 COX5B 0 0 145 151 1 1
IRF3 CARM1 0 0 74 166 1 2
IRF3 AOC3 0 0 170 169 1 1
IRF3 CCL4L1 0 0 283 282 1 1
IRF3 BCL2L1 0 0 293 293 1 2
IRF3 ANAPC5 0 0 358 362 1 1
IRF3 RELA 213 900 870 989 1 2
IRF3 PML 0 0 325 335 1 2
IRF3 SMAD2 270 0 162 362 1 2
IRF3 TLR4 0 600 805 918 1 2
IRF3 GAPDH 282 0 600 712 1 2
IRF3 UBE2V2 0 0 81 157 1 1
IRF3 FKBP8 270 0 60 363 1 1
IRF3 ATRX 0 0 112 158 1 1
IRF3 OAS2 0 900 505 949 1 1
IRF3 CD83 0 0 310 309 1 1
IRF3 CD14 0 600 150 681 1 1
IRF3 MAP2K7 0 0 212 212 1 1
IRF3 NOS2 0 0 341 341 1 2
IRF3 CX3CL1 0 0 157 156 1 1
IRF3 FAM214B 0 0 164 163 1 1
IRF3 ABL1 0 0 457 466 1 1
IRF3 UBE2D3 0 0 202 202 1 1
IRF3 SDHB 0 0 208 241 1 1
IRF3 PSMB1 0 0 72 211 1 1
IRF3 CREBBP 913 900 989 999 1 1
IRF3 PSMA1 0 0 0 183 1 1
IRF3 TRIM9 0 0 165 165 1 1
IRF3 TSKS 0 0 502 502 1 1
IRF3 DHX9 0 0 392 497 1 1
IRF3 BIRC2 0 0 339 339 1 1
IRF3 IFNG 0 0 336 537 1 2
IRF3 GSDMD 0 0 314 354 1 2
IRF3 CREB1 0 0 965 966 1 2
IRF3 CCL5 0 0 661 661 1 2
IRF3 PLCG2 0 0 215 215 1 1
IRF3 ANXA5 0 0 263 263 1 2
IRF3 HSPD1 0 0 460 463 1 1
IRF3 POLR2A 273 900 124 931 1 1
IRF3 RANBP2 0 0 161 187 1 1
IRF3 GSDMA 0 0 131 150 1 1
IRF3 CXCL13 0 0 193 193 1 1
IRF3 PLK1 0 0 154 153 1 2
IRF3 MFN1 0 0 235 267 1 2
IRF3 AKAP8L 0 0 45 165 1 1
IRF3 PSMB8 0 900 261 924 1 1
IRF3 EIF2AK2 0 0 452 462 1 2
IRF3 HAVCR2 0 0 241 240 1 1
IRF3 XRN1 0 0 182 218 1 1
IRF3 EIF3K 0 0 0 183 1 1
IRF3 CD8A 0 0 601 601 1 1
IRF3 CALR 0 0 267 268 1 1
IRF3 RIPK2 0 0 465 477 1 2
IRF3 TFAM 0 0 204 204 1 2
IRF3 CPSF6 0 0 165 169 1 1
IRF3 IRF6 0 900 409 913 1 1
IRF3 NCOA3 0 0 558 561 1 1
IRF3 TNFRSF13C 0 0 167 167 1 1
IRF3 SLAMF1 0 0 166 165 1 1
IRF3 TREM2 0 0 180 179 1 1
IRF3 CNPY3 0 0 231 247 1 1
IRF3 TICAM1 462 800 754 980 1 2
IRF3 NFKBIE 0 0 203 258 1 1
IRF3 GTF2F1 0 900 66 902 1 1
IRF3 GOLGA2 0 0 156 159 1 1
IRF3 FYN 0 0 150 163 1 1
IRF3 PSMD1 0 0 0 173 1 1
IRF3 IFNK 0 0 272 272 1 1
IRF3 LCK 0 0 181 222 1 1
IRF3 VCP 0 0 144 160 1 2
IRF3 YWHAE 0 0 204 242 1 1
IRF3 PQBP1 0 0 325 340 1 1
IRF3 CLEC6A 0 0 260 260 1 1
IRF3 CCRL2 0 0 193 193 1 1
IRF3 IL17RA 0 0 167 167 1 1
IRF3 ACAP1 0 0 0 153 1 1
IRF3 CCR5 0 0 367 367 1 1
IRF3 ARIH1 0 900 134 909 1 1
IRF3 DNAJC3 0 0 142 159 1 1
IRF3 RTP4 0 0 181 198 1 1
IRF3 LTA 0 0 184 251 1 1
IRF3 SOD1 0 0 134 168 1 2
IRF3 EIF3M 0 0 0 154 1 1
IRF3 USP4 0 0 218 250 1 1
IRF3 KPNA2 0 0 181 181 1 1
IRF3 CD69 0 0 263 263 1 1
IRF3 PARP14 0 0 160 159 1 1
IRF3 MIB2 0 0 241 240 1 1
IRF3 DTX4 0 600 257 690 1 1
IRF3 PRDX1 478 0 53 485 1 1
IRF3 BCL2L11 0 0 181 181 1 2
IRF3 SERPINB2 213 0 456 553 1 1
IRF3 PNMA3 0 0 134 158 1 1
IRF3 IL10RA 0 0 250 250 1 1
IRF3 HNRNPA1 0 0 149 164 1 1
IRF3 TRIM17 0 0 293 304 1 1
IRF3 KPNB1 0 0 101 179 1 1
IRF3 SIGLEC1 0 0 233 232 1 1
IRF3 AMFR 0 0 283 282 1 1
IRF3 BRD3 0 0 47 272 1 1
IRF3 ENSG00000173366 0 0 759 759 1 1
IRF3 MAML1 0 0 108 177 1 1
IRF3 ASF1A 0 0 261 261 1 1
IRF3 JUN 800 900 974 999 1 2
IRF3 DHX15 0 0 167 172 1 1
IRF3 DAPK1 0 0 447 447 1 2
IRF3 TYK2 0 0 564 596 1 1
IRF3 RPL37A 0 0 0 152 1 1
IRF3 TNIP3 0 0 170 169 1 1
IRF3 TMEM173 675 600 916 988 1 1
IRF3 TRIM11 0 0 193 205 1 1
IRF3 MAFB 270 0 330 490 1 1
IRF3 MVP 0 0 112 165 1 1
IRF3 GTF2H4 0 0 66 198 1 1
IRF3 TRIM6 0 0 255 376 1 1
IRF3 TRIM38 0 0 402 411 1 1
IRF3 NCOA2 0 0 447 447 1 1
IRF3 DEDD 0 0 107 242 1 1
IRF3 PVR 0 0 134 172 1 1
IRF3 CASP1 0 0 630 630 1 2
IRF3 TNFSF10 0 0 321 321 1 2
IRF3 ZFP36 0 0 210 210 1 1
IRF3 GBP4 0 0 194 194 1 1
IRF3 AIF1 0 0 180 228 1 2
IRF3 HSPA1A 0 0 181 181 1 1
IRF3 SH2D3C 0 0 596 596 1 1
IRF3 JAK3 0 0 181 193 1 1
IRF3 MAP2K3 0 0 261 264 1 1
IRF3 NLRX1 0 0 680 682 1 2
IRF3 STUB1 0 0 205 234 1 2
IRF3 CD40 0 0 502 512 1 2
IRF3 SELL 0 0 193 193 1 1
IRF3 FPR2 0 0 157 156 1 1
IRF3 MED25 0 0 0 168 1 1
IRF3 EPRS 0 0 136 371 1 1
IRF3 UBE2E1 0 0 218 218 1 1
IRF3 ACTB 0 900 609 959 1 2
IRF3 INS 0 0 252 252 1 2
IRF3 FCGR2B 0 0 265 265 1 1
IRF3 SQSTM1 0 0 324 323 1 2
IRF3 MICB 0 0 170 215 1 1
IRF3 RNF5 0 0 455 455 1 1
IRF3 JUNB 0 0 166 206 1 1
IRF3 GLI3 0 0 180 179 1 1
IRF3 ABCG1 0 0 161 161 1 2
IRF3 MAPK3 0 0 390 405 1 2
IRF3 PAX5 0 0 91 254 1 1
IRF3 MMP9 0 0 233 232 1 2
IRF3 B2M 0 0 218 233 1 1
IRF3 HPGDS 0 0 321 321 1 1
IRF3 IL21 0 0 0 186 1 1
IRF3 MBL2 0 0 212 212 1 1
IRF3 HSP90AA1 486 0 715 853 1 2
IRF3 PAX8 0 0 0 213 1 1
IRF3 IFNA16 0 900 124 909 1 1
IRF3 LBP 0 0 207 207 1 1
IRF3 IL3 0 0 193 193 1 1
IRF3 TFEB 0 0 138 156 1 2
IRF3 COX4I1 0 0 165 171 1 1
IRF3 CRP 0 0 181 181 1 2
IRF3 MUL1 0 0 167 167 1 2
IRF3 ATF2 800 900 444 987 1 1
IRF3 IFIT5 0 900 335 930 1 1
IRF3 CEBPA 0 0 184 183 1 1
IRF3 PSMA2 0 0 67 205 1 1
IRF3 SYT1 213 0 0 213 1 1
IRF3 SP100 0 0 286 311 1 1
IRF3 WDR82 270 0 0 270 1 1
IRF3 CXCR1 0 0 183 183 1 1
IRF3 TRIM31 0 0 258 269 1 1
IRF3 BCL2L12 0 0 259 315 1 1
IRF3 PTPRC 0 0 370 370 1 1
IRF3 FEN1 0 0 306 306 1 1
IRF3 SMDT1 0 0 150 160 1 1
IRF3 BCL10 0 0 293 295 1 1
IRF3 MLKL 0 0 317 327 1 2
IRF3 OCA2 0 0 380 380 1 1
IRF3 TRAPPC4 0 0 0 152 1 1
IRF3 RALB 189 0 295 403 1 2
IRF3 ICAM1 0 0 391 390 1 2
IRF3 UNC93B1 0 0 508 533 1 1
IRF3 RHBDF2 0 0 251 250 1 1
IRF3 MXI1 0 0 260 260 1 1
IRF3 MID1 0 0 153 166 1 1
IRF3 PARP1 0 0 188 188 1 2
IRF3 EIF4G1 0 0 287 289 1 2
IRF3 IFNAR2 0 0 696 696 1 1
IRF3 CD1C 0 0 243 242 1 1
IRF3 HSPA8 118 0 138 234 1 2
IRF3 ATG9A 0 0 321 374 1 2
IRF3 HNRNPH1 270 0 0 286 1 1
IRF3 IFNA7 0 900 193 916 1 1
IRF3 TNFRSF14 0 0 175 175 1 1
IRF3 GTF3A 0 900 0 900 1 1
IRF3 SPP1 0 0 181 181 1 2
IRF3 NMRAL1 0 0 197 197 1 1
IRF3 CXCL12 0 0 195 195 1 2
IRF3 UBE2N 0 0 392 422 1 1
IRF3 BAX 270 0 415 578 1 2
IRF3 RCN2 0 0 341 381 1 1
IRF3 TSSC1 0 0 0 406 1 1
IRF3 KLRK1 0 0 266 266 1 1
IRF3 GTF2H1 0 0 103 177 1 2
IRF3 LRRC59 0 0 95 151 1 1
IRF3 MYL1 0 0 0 193 1 1
IRF3 TLR5 0 0 602 602 1 1
IRF3 DUT 0 0 143 207 1 1
IRF3 AGER 0 0 248 248 1 2
IRF3 FKBP4 0 0 134 188 1 1
IRF3 DDX41 0 900 686 971 1 1
IRF3 AIM2 0 0 681 681 1 2
IRF3 DDX58 486 600 883 975 1 1
IRF3 FBXL20 0 0 296 296 1 1
IRF3 TRIM21 675 0 867 955 1 1
IRF3 DDX55 0 0 0 192 1 1
IRF3 DUSP10 0 0 454 454 1 1
IRF3 MB21D1 0 0 856 856 1 1
IRF3 UBXN1 0 0 209 257 1 1
IRF3 OTUB2 0 0 213 213 1 1
IRF3 CDH1 0 0 157 156 1 2
IRF3 BSG 0 0 329 354 1 1
IRF3 GLMN 184 0 0 188 1 1
IRF3 DPP4 0 0 123 196 1 1
IRF3 GTPBP1 0 0 202 202 1 1
IRF3 FKBP5 0 0 127 152 1 1
IRF3 PSMA4 0 0 58 190 1 1
IRF3 MAF 0 0 193 193 1 1
IRF3 LGALS4 0 0 206 206 1 1
IRF3 RNF31 0 0 329 380 1 1
IRF3 SMARCE1 0 900 0 900 1 1
IRF3 CRYGC 0 0 341 341 1 1
IRF3 MAVS 878 600 971 998 1 2
IRF3 PSMB2 0 0 67 240 1 1
IRF3 DNM2 0 0 54 170 1 1
IRF3 CALML6 0 0 255 299 1 1
IRF3 IL1A 0 0 465 465 1 1
IRF3 GBP1 0 0 392 392 1 1
IRF3 CCL4 0 0 414 414 1 1
IRF3 EIF2B3 0 0 0 225 1 1
IRF3 TRADD 0 0 524 594 1 1
IRF3 CUL5 0 0 181 185 1 1
IRF3 ABCA1 0 0 202 202 1 2
IRF3 TRIM62 0 0 167 180 1 1
IRF3 OTULIN 0 0 217 226 1 1
IRF3 CD276 0 0 287 321 1 1
IRF3 IFNE 0 0 224 224 1 1
IRF3 IFI6 0 900 365 935 1 1
IRF3 IDO1 0 0 260 260 1 1
IRF3 CD68 0 0 261 261 1 2
IRF3 CASP8 0 0 505 505 1 2
IRF3 ALB 0 0 392 396 1 2
IRF3 CCL2 0 0 556 556 1 2
IRF3 GYPC 0 0 202 202 1 1
IRF3 LRRFIP1 0 0 517 517 1 1
IRF3 KAT2A 0 0 181 372 1 1
IRF3 ILF3 0 0 187 193 1 1
IRF3 TYROBP 0 0 194 194 1 1
IRF3 EIF4E2 0 0 64 153 1 1
IRF3 TRIM41 0 0 181 193 1 1
IRF3 CASP7 0 0 204 207 1 1
IRF3 CUL1 270 0 597 693 1 1
IRF3 PRMT6 0 0 422 429 1 1
IRF3 SIRPA 0 0 166 165 1 1
IRF3 EP300 872 800 989 999 1 2
IRF3 IL9 0 0 207 207 1 1
IRF3 IL4 0 0 501 501 1 1
IRF3 IPO5 270 0 800 850 1 1
IRF3 SCARB1 0 0 161 161 1 1
IRF3 IL27 0 0 244 243 1 1
IRF3 RBM42 0 0 0 156 1 1
IRF3 IFNA6 0 900 306 928 1 1
IRF3 BIRC3 0 0 218 218 1 1
IRF3 B3GNT3 0 0 155 154 1 1
IRF3 ROBO3 0 0 270 270 1 1
IRF3 IL17F 0 0 181 181 1 1
IRF3 SMAD3 0 0 213 213 1 2
IRF3 DPH2 0 0 0 173 1 1
IRF3 IFI44L 0 0 322 327 1 1
IRF3 TNFRSF10A 0 0 158 157 1 1
IRF3 CASP9 0 0 287 286 1 2
IRF3 PYHIN1 0 0 334 334 1 1
IRF3 CNOT7 0 0 72 164 1 1
IRF3 DDX19B 0 0 425 454 1 1
IRF3 TRAF6 270 0 776 834 1 2
IRF3 DUSP12 0 0 448 448 1 1
IRF3 CYCS 0 0 296 326 1 2
IRF3 MAPK9 270 0 167 369 1 2
IRF3 CXCL11 0 0 390 390 1 1
IRF3 TLR7 0 0 760 760 1 2
IRF3 DHX36 0 0 518 518 1 1
IRF3 IL17A 0 0 457 457 1 2
IRF3 EGF 0 0 251 250 1 2
IRF3 PELI1 0 0 310 311 1 1
IRF3 FCGRT 0 0 99 180 1 1
IRF3 NFRKB 0 0 48 156 1 1
IRF3 PCSK1 0 0 170 169 1 1
IRF3 HSPA4 0 0 288 321 1 1
IRF3 IRF2 0 900 611 923 1 1
IRF3 PCBP2 0 0 344 377 1 1
IRF3 RNASEH2C 0 0 243 242 1 1
IRF3 XCR1 0 0 167 167 1 1
IRF3 USP22 0 0 307 307 1 1
IRF3 APOBEC3F 0 0 175 175 1 1
IRF3 DICER1 0 0 261 262 1 1
IRF3 PPIB 213 0 421 525 1 1
IRF3 RIOK3 270 0 134 340 1 1
IRF3 CX3CR1 0 0 219 219 1 1
IRF3 TRIM5 0 0 465 473 1 1
IRF3 HSP90B1 0 0 204 217 1 1
IRF3 ENDOU 0 0 154 212 1 1
IRF3 ISG20 0 900 503 948 1 1
IRF3 BPTF 0 0 0 277 1 1
IRF3 DDX1 0 0 413 442 1 1
IRF3 CCR2 0 0 310 309 1 2
IRF3 DEFB103B 0 0 161 161 1 1
IRF3 PPARA 0 0 240 239 1 2
IRF3 TRIM55 192 0 45 207 1 1
IRF3 FBXO7 270 0 0 278 1 1
IRF3 NFYA 0 0 147 158 1 1
IRF3 CXCL9 0 0 459 459 1 1
IRF3 ZDHHC1 0 0 294 294 1 1
IRF3 MGME1 0 0 372 379 1 1
IRF3 TUFM 0 0 213 235 1 2
IRF3 BATF3 0 0 234 236 1 1
IRF3 OTUB1 0 0 284 337 1 1
IRF3 DNASE2 0 0 194 209 1 1
IRF3 PSMD11 0 0 0 173 1 1
IRF3 IFIH1 0 600 880 952 1 1
IRF3 HBZ 0 0 155 154 1 1
IRF3 PXN 0 0 150 210 1 1
IRF3 HIST2H3PS2 0 0 286 286 1 1
IRF3 DIABLO 0 0 230 252 1 2
IRF3 P2RX7 0 0 204 204 1 2
IRF3 IFNA10 0 900 123 909 1 1
IRF3 BAZ1B 0 0 0 246 1 1
IRF3 CSK 0 0 103 150 1 1
IRF3 CISH 0 0 450 450 1 1
IRF3 MX2 0 900 517 949 1 1
IRF3 PRF1 0 0 310 309 1 1
IRF3 IL2RG 0 0 134 153 1 1
IRF3 NR3C1 0 900 247 921 1 1
IRF3 SMARCB1 0 900 90 905 1 1
IRF3 CCR1 0 0 193 193 1 1
IRF3 MAPK8 270 0 391 548 1 2
IRF3 ARG1 0 0 288 288 1 2
IRF3 SEC61G 0 0 0 156 1 1
IRF3 PABPN1 0 0 136 167 1 1
IRF3 MAP2K4 0 0 206 206 1 1
IRF3 IFNL2 0 0 517 526 1 1
IRF3 SUPT5H 0 0 0 157 1 1
IRF3 FKBP1C 0 0 253 252 1 1
IRF3 BCL2A1 0 0 156 155 1 1
IRF3 CSNK2A1 0 0 125 158 1 1
IRF3 IFI16 0 900 709 969 1 1
IRF3 RELB 0 0 464 468 1 2
IRF3 CXCL3 0 0 156 155 1 1
IRF3 RAB7A 0 0 194 198 1 2
IRF3 TNFAIP3 0 0 379 379 1 2
IRF3 MYL4 0 0 0 193 1 1
IRF3 NFKB2 0 0 393 409 1 1
IRF3 IFNAR1 0 0 767 829 1 1
IRF3 MAP3K14 270 0 96 311 1 1
IRF3 IL5 0 0 325 325 1 1
IRF3 BTK 0 0 260 271 1 1
IRF3 RFXANK 0 0 46 195 1 1
IRF3 SOCS1 482 0 519 740 1 1
IRF3 RNF41 0 0 331 351 1 1
IRF3 MERTK 0 0 174 186 1 1
IRF3 TREX1 0 0 390 403 1 1
IRF3 UVRAG 0 0 123 165 1 2
IRF3 SOCS4 0 0 212 212 1 1
IRF3 CSF1R 0 0 184 183 1 1
IRF3 DEFB4A 0 0 213 213 1 1
IRF3 ITIH4 0 0 234 234 1 1
IRF3 SNF8 0 0 64 163 1 1
IRF3 IRF7 486 900 988 967 1 1
IRF3 MAPK1 0 0 432 432 1 2
IRF3 ITPA 0 0 194 208 1 1
IRF3 IFNW1 0 0 146 158 1 1
IRF3 ATF3 0 0 288 290 1 2
IRF3 G3BP1 0 0 294 294 1 1
IRF3 GBP5 0 0 241 240 1 1
IRF3 USP19 130 0 81 179 1 1
IRF3 IFNL1 0 0 566 574 1 1
IRF3 IFI35 0 900 373 937 1 1
IRF3 KRT37 0 0 161 161 1 1
IRF3 TDG 0 0 357 357 1 1
IRF3 IL1RN 0 0 201 201 1 1
IRF3 VPS51 0 0 0 398 1 1
IRF3 USP5 0 0 143 179 1 1
IRF3 CD44 0 0 217 217 1 2
IRF3 RNF185 0 0 151 150 1 1
IRF3 IL7 0 0 174 173 1 1
IRF3 C22orf29 0 0 163 163 1 1
IRF3 TIRAP 0 0 732 738 1 1
IRF3 PIH1D1 0 0 46 171 1 1
IRF3 IFITM1 0 900 417 940 1 1
IRF3 SMARCD1 0 900 0 902 1 1
IRF3 NBR1 0 0 171 171 1 2
IRF3 TANK 270 600 744 920 1 2
IRF3 TNF 0 0 690 715 1 2
IRF3 ITCH 0 0 294 294 1 1
IRF3 USP14 0 0 181 217 1 2
IRF3 DDX3X 270 0 822 865 1 1
IRF3 RBM8A 0 0 140 150 1 1
IRF3 PPP1R15A 0 0 203 203 1 2
IRF3 RNF135 0 600 561 819 1 1
IRF3 IL23R 0 0 142 161 1 1
IRF3 HERC6 0 0 181 181 1 1
IRF3 CD209 0 0 395 394 1 1
IRF3 NAIP 0 0 215 215 1 1
IRF3 TRAF3IP3 0 0 323 323 1 1
IRF3 FIS1 0 0 123 153 1 2
IRF3 IFI30 0 0 180 221 1 1
IRF3 IFI27 0 900 321 929 1 1
IRF3 CD38 0 0 160 159 1 2
IRF3 HPRT1 0 0 277 280 1 1
IRF3 CD46 0 0 204 204 1 2
IRF3 RNASEL 0 900 665 965 1 1
IRF3 IFI44 0 0 401 405 1 1
IRF3 PSMA7 0 0 182 301 1 1
IRF3 VPRBP 0 0 181 191 1 1
IRF3 TBC1D17 0 0 102 186 1 1
IRF3 CTLA4 0 0 370 370 1 2
IRF3 CCL19 0 0 217 217 1 1
IRF3 LDLR 0 0 170 169 1 2
IRF3 GNB2L1 0 0 432 468 1 1
IRF3 SAV1 0 0 73 186 1 1
IRF3 PSMA3 0 0 71 182 1 1
IRF3 PTOV1 0 0 0 183 1 1
IRF3 PTK2B 0 0 181 181 1 1
IRF3 ELMO2 0 0 0 152 1 1
IRF3 UBB 0 900 84 904 1 1
IRF3 CAT 0 0 171 171 1 2
IRF3 MCUR1 0 0 0 179 1 1
IRF3 RETNLB 0 0 157 156 1 1
IRF3 FSTL1 0 0 226 226 1 1
IRF3 HGF 0 0 89 165 1 2
IRF3 TRAF3IP2 270 0 125 333 1 1
IRF3 CANX 0 0 218 218 1 2
IRF3 TXN 0 0 143 153 1 1
IRF3 USP13 0 0 162 161 1 1
IRF3 UXT 0 0 113 156 1 1
IRF3 MGA 0 0 285 284 1 1
IRF3 CBL 270 0 183 382 1 1
IRF3 DDX60 0 0 415 414 1 1
IRF3 NUP62 282 0 92 328 1 1
IRF3 CD207 0 0 153 152 1 1
IRF3 HIST2H2BE 0 0 170 169 1 1
IRF3 PPP2CA 486 0 112 541 1 1
IRF3 PRKDC 0 900 182 915 1 2
IRF3 EIF4E 0 0 203 203 1 2
IRF3 CHMP4B 0 0 0 183 1 2
IRF3 NCOR1 0 0 189 223 1 1
IRF3 NLRP2 0 0 112 174 1 1
IRF3 KAT2B 0 900 204 936 1 1
IRF3 FCGR1A 0 0 211 211 1 1
IRF3 INO80E 0 0 0 179 1 1
IRF3 RPS6KB1 0 0 183 183 1 2
IRF3 SAP30 0 0 202 254 1 1
IRF3 JUND 0 0 193 193 1 1
IRF3 FLT3LG 0 0 182 181 1 1
IRF3 TRIM65 0 0 247 268 1 1
IRF3 HLA-E 0 900 118 908 1 1
IRF3 CD274 0 0 379 379 1 2
IRF3 CCND1 0 0 166 165 1 2
IRF3 AIMP1 0 0 0 181 1 1
IRF3 IFIT2 0 900 681 966 1 1
IRF3 MTIF3 0 0 0 152 1 1
IRF3 CD19 0 0 294 294 1 1
IRF3 UBE2I 0 0 233 274 1 1
IRF3 NCF1 0 0 160 159 1 1
IRF3 IRAK2 0 0 524 531 1 1
IRF3 SMARCC1 0 900 0 900 1 1
IRF3 C1QBP 0 0 252 266 1 1
IRF3 TUBA1C 0 0 0 171 1 1
IRF3 RAG1 0 0 181 181 1 1
IRF3 SMURF2 128 0 124 203 1 1
IRF3 SCD 0 0 67 191 1 1
IRF3 IRF8 0 0 760 310 1 1
IRF3 ADA 0 0 289 288 1 1
IRF3 SRC 0 0 458 466 1 2
IRF3 FOXO3 0 0 218 218 1 2
IRF3 BBOX1 0 0 391 418 1 1
IRF3 APOE 0 0 211 228 1 2
IRF3 TNFSF11 0 0 184 183 1 2
IRF3 EEA1 0 0 212 214 1 2
IRF3 COMMD10 0 0 45 159 1 1
IRF3 ACIN1 0 0 96 202 1 1
IRF3 C16orf13 0 0 108 151 1 1
IRF3 STAT6 0 0 459 466 1 1
IRF3 EIF2AK3 0 0 261 274 1 2
IRF3 CD180 0 0 183 183 1 1
IRF3 PSMD7 0 0 0 188 1 1
IRF3 ATG3 0 0 134 162 1 2
IRF3 PLSCR1 0 0 193 193 1 1
IRF3 RSAD2 0 900 662 970 1 1
IRF3 TLR3 0 600 905 960 1 2
IRF3 TUBB8 130 0 0 223 1 1
IRF3 TRIM28 0 0 195 348 1 2
IRF3 JAK1 0 0 594 600 1 2
IRF3 SKP1 0 0 193 230 1 2
IRF3 EIF2S1 0 0 390 426 1 2
IRF3 RPL11 0 0 44 160 1 1
IRF3 YY1 0 0 188 192 1 1
IRF3 PIAS4 270 0 208 397 1 1
IRF3 RAB11A 0 0 184 190 1 2
IRF3 TOMM20 0 0 169 183 1 2
IRF3 MARCH5 0 0 252 276 1 1
IRF3 NFATC2 0 0 170 169 1 1
IRF3 NDFIP1 0 0 148 164 1 1
IRF3 MCTS1 0 0 0 169 1 1
IRF3 CLEC5A 0 0 180 179 1 1
IRF3 TBK1 917 800 989 999 1 2
IRF3 TCHP 0 0 182 181 1 1
IRF3 TICAM2 213 600 508 857 1 1
IRF3 SLFN11 0 0 171 171 1 1
IRF3 FOXP3 0 0 322 321 1 2
IRF3 TRIM14 0 0 364 364 1 1
IRF3 HMOX1 0 0 510 510 1 2
IRF3 METTL14 0 0 0 152 1 1
IRF3 CTCF 0 0 163 169 1 1
IRF3 USP7 0 0 235 259 1 1
IRF3 GTF2B 0 900 180 914 1 1
IRF3 RIPK3 0 0 391 400 1 2
IRF3 CDA 0 0 157 156 1 1
IRF3 IFIT1 0 900 744 973 1 1
IRF3 HEXIM1 0 0 122 152 1 1
IRF3 RB1 157 0 116 222 1 2
IRF3 RASSF5 0 0 418 418 1 1
IRF3 VDAC1 0 0 211 211 1 2
IRF3 DDB1 0 0 138 178 1 1
IRF3 TSC2 0 0 167 173 1 2
IRF3 STAT5B 0 0 270 279 1 1
IRF3 RBX1 0 0 134 171 1 1
IRF3 RAB7B 0 0 216 216 1 1
IRF3 C1QB 0 0 103 154 1 1
IRF3 TRIM29 0 0 266 266 1 1
IRF3 RAE1 0 0 67 301 1 1
IRF3 NOSIP 0 0 67 257 1 1
IRF3 VCAM1 0 0 239 238 1 1
IRF3 IFIT3 0 900 557 953 1 1
IRF3 INPP5D 0 0 210 210 1 1
IRF3 MBTPS1 0 0 166 165 1 1
IRF3 CD4 0 0 566 569 1 2
IRF3 FAS 0 0 218 223 1 2
IRF3 SUMO1 0 0 260 275 1 1
IRF3 UBR4 0 0 155 321 1 1
IRF3 ACKR1 0 0 167 167 1 1
IRF3 GTF2A1 0 900 0 903 1 1
IRF3 LY96 0 600 731 890 1 1
IRF3 IL12RB1 0 0 181 181 1 1
IRF3 CSF2 0 0 517 521 1 1
IRF3 PPARG 0 0 486 486 1 2
IRF3 UBE3A 270 0 323 508 1 1
IRF3 AKT1 270 0 469 604 1 2
IRF3 GBP2 0 900 303 927 1 1
IRF3 PPP2R4 0 0 174 173 1 1
IRF3 XIAP 270 0 447 592 1 2
IRF3 IFNLR1 0 0 456 456 1 1
IRF3 CLEC4C 0 0 251 250 1 1
IRF3 KLF4 0 0 160 159 1 2
IRF3 IKBKB 282 0 826 872 1 2
IRF3 NLRC4 0 0 455 455 1 2
IRF3 CLDN1 0 0 135 168 1 1
IRF3 ENSG00000279392 0 0 134 171 1 1
IRF3 ACE2 0 0 171 176 1 2
IRF3 ATF6 0 0 232 231 1 2
IRF3 EIF3L 0 0 46 168 1 1
IRF3 BRDT 0 0 0 242 1 1
IRF3 CREB3L4 0 0 270 270 1 1
IRF3 USP25 0 0 267 280 1 1
IRF3 CXCL10 0 0 690 690 1 2
IRF3 ZNHIT2 0 0 0 179 1 1
IRF3 MALT1 0 0 249 248 1 1
IRF3 C15orf40 0 0 0 173 1 1
IRF3 PHF20 0 0 167 167 1 1
IRF3 PIKFYVE 0 0 134 171 1 2
IRF3 CYLD 0 0 507 507 1 1
IRF3 HSP90AB1 129 0 67 184 1 2
IRF3 AXL 0 0 245 256 1 2
IRF3 PDLIM2 0 0 216 233 1 1
IRF3 DDX56 0 0 404 433 1 1
IRF3 GP2 0 0 245 244 1 1
IRF3 USP3 0 0 228 227 1 1
IRF3 TCEB2 0 0 95 153 1 1
IRF3 BCL6 0 0 170 169 1 1
IRF3 PINK1 270 0 165 364 1 2
IRF3 IFNGR2 0 0 285 306 1 1
IRF3 SSR2 0 0 324 323 1 1
IRF3 PHGDH 0 0 424 424 1 1
IRF3 C9orf89 0 0 112 167 1 1
IRF3 GPT 0 0 219 219 1 1
IRF3 NOP10 0 0 0 153 1 1
IRF3 NLRP7 0 0 137 198 1 1
IRF3 PRR12 0 0 156 201 1 1
IRF3 ARG2 0 0 211 211 1 1
IRF3 VTI1A 0 0 0 167 1 1
IRF3 UBE2E2 0 0 268 268 1 1
IRF3 UBA7 0 0 326 325 1 1
IRF3 CD34 0 0 142 156 1 2
IRF3 RNASEH2B 0 0 260 260 1 1
IRF3 IMMP1L 0 0 51 215 1 1
IRF3 TLR9 0 0 759 759 1 2
IRF3 PRKRA 0 0 153 152 1 1
IRF3 PYCARD 0 0 391 404 1 2
IRF3 MAP3K1 0 0 218 218 1 1
IRF3 ANKRA2 0 0 0 160 1 1
IRF3 CD1D 0 0 232 231 1 1
IRF3 MAFK 0 0 107 171 1 1
IRF3 HSPA5 0 0 203 203 1 2
IRF3 GBP6 0 0 167 167 1 1
IRF3 MID2 0 0 155 168 1 1
IRF3 CCL8 0 0 218 218 1 1
IRF3 HAX1 0 0 96 176 1 1
IRF3 BTRC 0 0 284 284 1 1
IRF3 ARHGEF1 0 0 0 171 1 1
IRF3 FOXO1 270 0 155 356 1 2
IRF3 KRAS 0 0 170 169 1 2
IRF3 SNRNP200 0 0 95 155 1 1
IRF3 RNF122 0 0 174 173 1 1
IRF3 C14orf1 0 0 0 152 1 1
IRF3 CDK9 0 0 123 169 1 1
IRF3 IFNGR1 0 0 413 429 1 1
IRF3 HLA-B 0 900 96 905 1 1
IRF3 CCL17 0 0 171 171 1 1
IRF3 FASLG 0 0 261 261 1 1
IRF3 KDM6B 0 0 163 176 1 1
IRF3 FOS 0 0 391 392 1 2
IRF3 MNDA 0 0 261 274 1 1
IRF3 PSME2 0 0 112 159 1 1
IRF3 CLEC9A 0 0 202 202 1 1
IRF3 SOCS3 0 0 457 457 1 1
IRF3 DDX24 0 0 260 260 1 1
IRF3 IRG1 0 0 294 294 1 1
IRF3 TCEB1 0 0 73 153 1 1
IRF3 DDX31 0 0 0 190 1 1
IRF3 RXRA 0 0 155 158 1 1
IRF3 STAT5A 0 0 301 310 1 1
IRF3 NKPD1 0 0 0 160 1 1
IRF3 TADA3 0 0 180 218 1 1
IRF3 RPS11 0 0 134 165 1 1
IRF3 IRAK3 0 0 459 467 1 1
IRF3 TNIP1 0 0 202 207 1 1
IRF3 SIGIRR 0 0 273 288 1 1
IRF3 PTPN11 0 900 222 919 1 1
IRF3 COPS6 0 0 0 150 1 1
IRF3 XAF1 0 900 166 914 1 1
IRF3 IFNL3 0 0 559 567 1 1
IRF3 CD86 0 0 506 509 1 1
IRF3 TBKBP1 0 0 519 519 1 1
IRF3 IFNA13 0 600 380 743 1 1
IRF3 SCD5 0 0 0 169 1 1
IRF3 NIF3L1 0 0 63 163 1 1
IRF3 SHARPIN 0 0 261 297 1 1
IRF3 CD81 0 0 289 288 1 1
IRF3 GSS 270 0 0 330 1 1
IRF3 CARD11 0 0 189 189 1 1
IRF3 IFNA17 0 900 562 954 1 1
IRF3 NOD1 0 0 550 550 1 2
IRF3 ZC3HAV1 0 0 366 385 1 1
IRF3 OTUD7B 0 0 210 210 1 1
IRF3 CCL7 0 0 278 278 1 1
IRF3 BECN1 0 0 491 534 1 2
IRF3 LRP1 0 0 337 337 1 1
IRF3 TLR6 0 0 561 561 1 1
IRF3 IL2 0 0 421 421 1 1
IRF3 TLR2 270 0 710 779 1 2
IRF3 AGBL5 0 0 161 161 1 1
IRF3 PIAS1 0 0 521 521 1 1
IRF3 PMAIP1 0 0 277 277 1 2
IRF3 MEX3C 0 0 203 203 1 1
IRF3 IPO7 0 0 383 403 1 1
IRF3 LILRA4 0 0 171 171 1 1
IRF3 DUSP1 0 0 287 286 1 1
IRF3 TRAF3 486 600 802 957 1 2
IRF3 GTF2H2 0 0 134 190 1 1
IRF3 PPM1A 0 0 188 253 1 1
IRF3 TOLLIP 0 0 375 375 1 1
IRF3 HSH2D 0 0 155 154 1 1
IRF3 KIAA2013 0 0 0 153 1 1
IRF3 PPM1B 0 0 249 360 1 1
IRF3 TNFSF13B 0 0 294 294 1 1
IRF3 PSMA5 111 0 74 214 1 1
IRF3 IFNA14 0 900 166 913 1 1
IRF3 ATG12 0 0 325 325 1 2
IRF3 IL13 0 0 392 392 1 2
IRF3 TNFRSF10B 0 0 183 183 1 2
IRF3 CD28 0 0 294 294 1 1
IRF3 CYBB 0 0 284 284 1 2
IRF3 TRIM56 0 0 558 567 1 1
IRF3 TRIM22 0 0 342 381 1 1
IRF3 ASZ1 0 0 286 286 1 1
IRF3 CXCL5 0 0 212 212 1 1
IRF3 PPIA 0 0 430 450 1 1
IRF3 IFNA5 0 600 325 720 1 1
IRF3 IL33 0 0 329 329 1 2
IRF3 CXCL1 0 0 408 408 1 2
IRF3 UBE2V1 0 0 324 328 1 1
IRF3 CPSF4 0 0 518 552 1 1
IRF3 GMPPB 0 0 0 201 1 1
IRF3 NLRP3 0 0 602 602 1 2
IRF3 REL 0 0 502 515 1 2
IRF3 DAXX 0 0 229 233 1 1
IRF3 IL1RL1 0 0 155 154 1 1
IRF3 MSR1 0 0 184 183 1 1
IRF3 CLEC4M 0 0 194 194 1 1
IRF3 SMURF1 0 0 181 181 1 1
IRF3 PTGS2 0 0 335 335 1 2
IRF3 EEF1A1 0 0 134 193 1 1
IRF3 CCL11 0 0 203 203 1 1
IRF3 PSMB9 0 0 259 275 1 1
IRF3 ARID3A 0 0 107 299 1 1
IRF3 CASP3 0 0 455 455 1 2
IRF3 KIDINS220 0 0 0 160 1 1
IRF3 HCK 0 0 142 155 1 1
IRF3 HMGB3 0 0 540 540 1 1
IRF3 NOD2 0 0 603 603 1 2
IRF3 SIPA1L1 0 0 209 227 1 1
IRF3 ECSIT 0 0 322 342 1 1
IRF3 CIITA 0 0 294 294 1 1
IRF3 ATG16L1 0 0 316 315 1 2
IRF3 IFIT1B 0 0 170 169 1 1
IRF3 CEBPB 0 0 325 325 1 2
IRF3 UBE2L6 0 900 322 929 1 1
IRF3 LTBR 0 0 164 182 1 1
IRF3 PRDM1 0 0 193 193 1 1
IRF3 HDAC1 0 0 245 244 1 2
IRF3 CSF1 0 0 400 400 1 1
IRF3 RIPK1 0 0 600 606 1 2
IRF3 CDKN2A 0 0 201 201 1 2
IRF3 SOCS2 0 0 261 261 1 1
IRF3 RPS27A 270 900 49 927 1 1
IRF3 ITGAX 0 0 470 470 1 1
IRF3 XRCC5 0 900 167 915 1 1
IRF3 PBRM1 0 0 0 248 1 1
IRF3 MRC1 0 0 297 297 1 1
IRF3 RBL2 157 0 66 178 1 1
IRF3 FBXO17 270 0 386 533 1 1
IRF3 USF2 0 0 261 304 1 1
IRF3 CENPC 0 0 0 201 1 1
IRF3 NPLOC4 0 0 95 157 1 1
IRF3 SAMHD1 0 900 607 959 1 1
IRF3 CHUK 0 0 683 687 1 1
IRF3 GTF2E1 0 900 43 903 1 1
IRF3 HLA-A 0 900 167 913 1 1
IRF3 LYAR 0 0 441 449 1 1
IRF3 TRIM26 270 0 324 493 1 1
IRF3 FCGR3B 0 0 270 270 1 1
IRF3 CCL22 0 0 218 218 1 1
IRF3 PNKP 0 0 57 153 1 1
IRF3 CCL3 0 0 460 459 1 1
IRF3 BAZ2B 0 0 0 242 1 1
IRF3 ENSG00000267261 0 0 0 265 1 1
IRF3 TYRO3 0 0 210 222 1 1
IRF3 RNF26 0 0 307 307 1 1
IRF3 MARCO 0 0 150 165 1 1
IRF3 CECR2 0 0 0 265 1 1
IRF3 TRIM63 192 0 46 208 1 1
IRF3 IL23A 0 0 266 282 1 1
IRF3 THBD 0 0 218 218 1 1
IRF3 IL18RAP 0 0 90 152 1 1
IRF3 TOMM70A 270 0 682 778 1 1
IRF3 ATM 0 0 296 301 1 2
IRF3 TRIM32 0 0 373 382 1 1
IRF3 MRE11A 0 900 156 914 1 1
IRF3 PSMB10 0 0 156 174 1 1
IRF3 RNF128 0 0 156 155 1 1
IRF3 CCL20 0 0 320 319 1 1
IRF3 IL10 0 0 607 616 1 2
IRF3 TNPO1 0 0 61 174 1 1
IRF3 RFX5 0 0 184 196 1 1
IRF3 CXCL2 0 0 342 342 1 1
IRF3 IRAK4 0 0 661 666 1 1
IRF3 NICN1 0 0 62 181 1 1
IRF3 TRAT1 0 0 561 561 1 1
IRF3 OTUD5 0 0 518 518 1 1
IRF3 SELE 0 0 217 217 1 1
IRF3 ATG7 0 0 241 275 1 2
IRF3 IFNA8 0 900 134 910 1 1
IRF3 SMARCC2 0 900 0 912 1 1
IRF3 CMPK2 0 0 193 196 1 1
IRF3 ACTG1 0 0 186 186 1 1
IRF3 CASP5 0 0 164 163 1 1
IRF3 TRAF7 0 0 288 310 1 1
IRF3 KIAA0226 0 0 599 599 1 1
IRF3 AGBL4 0 0 181 181 1 1
IRF3 NFATC1 0 0 150 173 1 2
IRF3 PDCD1LG2 0 0 160 159 1 1
IRF3 VEGFA 0 0 275 275 1 2
IRF3 FPR1 0 0 154 153 1 1
IRF3 IRF4 0 900 543 918 1 1
IRF3 NLRP6 0 0 287 286 1 1
IRF3 IFNA21 0 900 595 958 1 1
IRF3 TRAFD1 0 0 387 400 1 1
IRF3 PVRL1 0 0 150 166 1 1
IRF3 BST2 0 900 504 949 1 1
IRF3 PTEN 0 0 205 205 1 2
IRF3 PLP2 0 0 557 557 1 1
IRF3 FBXL2 0 0 295 295 1 1
IRF3 DAK 0 0 144 162 1 1
IRF3 SCAF1 0 0 155 243 1 1
IRF3 CLEC4E 0 0 282 282 1 1
IRF3 CTTNBP2 0 0 151 150 1 1
IRF3 MAPK14 0 0 295 295 1 2
IRF3 UBA52 0 900 57 901 1 1
IRF3 SREBF1 0 0 159 165 1 1
IRF3 FCGR2A 0 0 286 286 1 1
IRF3 ZC3H12A 270 0 261 437 1 1
IRF3 NFKBIA 0 0 681 681 1 2
IRF3 KIT 130 0 112 194 1 2
IRF3 SYK 0 0 406 415 1 2
IRF3 NUP98 0 0 151 161 1 1
IRF3 UBE2M 0 0 89 165 1 1
IRF3 S1PR1 189 0 340 442 1 1
IRF3 MAP3K5 0 0 218 218 1 1
IRF3 OPTN 0 0 597 598 1 2
IRF3 MYL3 0 0 0 193 1 1
IRF3 ITGAM 0 0 465 465 1 1
IRF3 EMC7 0 0 0 183 1 1
IRF3 PDCD1 0 0 161 179 1 2
IRF3 IP6K2 0 900 0 900 1 1
IRF3 LYN 0 0 231 243 1 1
IRF3 COPS5 0 0 113 172 1 1
IRF3 PPP1CA 0 0 361 401 1 1
IRF3 IFNB1 0 900 910 990 1 1
IRF3 HMGB1 0 900 487 946 1 2
IRF3 IRF5 462 900 935 962 1 1
IRF3 NCL 0 0 194 194 1 2
IRF3 PSMD12 0 0 0 156 1 1
IRF3 ESR1 0 0 170 169 1 2
IRF3 SIKE1 0 650 456 801 1 1
IRF3 CTSB 0 0 216 222 1 2
IRF3 TP53BP1 0 0 149 153 1 1
IRF3 SPI1 0 0 379 392 1 1
IRF3 LMNB1 0 0 193 210 1 1
IRF3 IL10RB 0 0 369 388 1 1
IRF3 SIRT1 0 0 203 211 1 2
IRF3 ELF4 0 0 670 670 1 1
IRF3 SMARCA4 0 900 90 905 1 1
IRF3 MCL1 0 0 203 203 1 2
IRF3 ERVW-1 0 0 278 278 1 1
IRF3 CXCR3 0 0 325 325 1 1
IRF3 YAP1 270 0 451 582 1 2
IRF3 STAT2 0 900 776 976 1 1
IRF3 SCARF1 0 0 181 181 1 1
IRF3 XBP1 0 0 293 293 1 2
IRF3 IRF1 270 900 879 950 1 2
IRF3 HLA-C 0 900 94 907 1 1
IRF3 KIAA0368 0 0 0 152 1 1
IRF3 MAP2K6 0 0 207 207 1 1
IRF3 ATG5 0 0 391 394 1 2
IRF3 RNF114 0 0 181 222 1 1
IRF3 CALCOCO2 0 0 349 349 1 2
IRF3 MT-ND1 0 0 0 171 1 1
IRF3 TLR8 0 0 681 681 1 1
IRF3 TIA1 0 0 163 163 1 1
IRF3 BRD8 0 0 0 242 1 1
IRF3 KCMF1 0 0 0 154 1 1
IRF3 SH2D3A 0 0 891 891 1 1
IRF3 ISG15 0 800 839 966 1 2
IRF3 UBC 0 900 134 909 1 2
IRF3 TEAD4 0 0 422 422 1 1
IRF3 MAP1LC3B 0 0 174 199 1 2
IRF3 FAM20C 270 0 0 280 1 1
IRF3 NFKBIB 0 0 281 281 1 1
IRF3 ARID1A 0 900 45 900 1 1
IRF3 GBP3 0 0 204 204 1 1
IRF3 USP18 0 0 519 519 1 1
IRF3 TGFBR1 0 0 540 547 1 1
IRF3 SOCS6 0 0 202 202 1 1
IRF3 HLA-F 0 900 60 901 1 1
IRF3 TSG101 0 0 151 177 1 2
IRF3 ENSG00000255819 0 0 263 263 1 1
IRF3 VAV1 0 0 151 151 1 1
IRF3 PRRG2 0 0 148 310 1 1
IRF3 TERT 0 0 173 173 1 2
IRF3 PSMD14 0 0 108 230 1 1
IRF3 TIAL1 0 0 166 172 1 1
IRF3 TBP 0 0 246 245 1 1
IRF3 FN1 0 0 241 240 1 2
IRF3 IKBKG 0 800 667 930 1 1
IRF3 RAG2 0 0 150 173 1 1
IRF3 CCR7 0 0 282 282 1 1
IRF3 CXCR5 0 0 160 159 1 1
IRF3 RCOR1 0 0 90 156 1 1
IRF3 C3 0 0 204 204 1 2
IRF3 HNRNPDL 0 0 124 155 1 1
IRF3 OTUD1 270 0 163 362 1 1
IRF3 PRKCA 0 0 182 181 1 1
IRF3 ULK1 270 0 234 416 1 2
IRF3 TBX21 0 0 261 261 1 1
IRF3 NCAM1 0 0 156 155 1 1
IRF3 HNRNPK 0 0 90 157 1 1
IRF3 LATS1 0 0 136 164 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0003677 Molecular Function DNA binding enables NAS
GO:0001216 Molecular Function DNA-binding transcription activator activity enables IDA
GO:0001228 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific enables IMP
GO:0003700 Molecular Function DNA-binding transcription factor activity enables IC
GO:0003700 Molecular Function DNA-binding transcription factor activity enables IDA
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables IBA
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables IDA
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables ISA
GO:0001227 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific enables IEA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IBA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IDA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IMP
GO:0042802 Molecular Function identical protein binding enables IPI
GO:1990841 Molecular Function promoter-specific chromatin binding enables IEA
GO:0005515 Molecular Function protein binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0019904 Molecular Function protein domain specific binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0042803 Molecular Function protein homodimerization activity enables IPI
GO:0043565 Molecular Function sequence-specific DNA binding enables IDA
GO:1990837 Molecular Function sequence-specific double-stranded DNA binding enables IDA
GO:0006974 Biological Process DNA damage response involved_in TAS
GO:0039530 Biological Process MDA-5 signaling pathway involved_in TAS
GO:0035666 Biological Process TRIF-dependent toll-like receptor signaling pathway involved_in IDA
GO:0006915 Biological Process apoptotic process involved_in TAS
GO:0071360 Biological Process cellular response to exogenous dsRNA involved_in IEA
GO:0098586 Biological Process cellular response to virus involved_in IDA
GO:0002753 Biological Process cytoplasmic pattern recognition receptor signaling pathway involved_in IDA
GO:0051607 Biological Process defense response to virus involved_in ISS
GO:0002376 Biological Process immune system process involved_in IBA
GO:0031663 Biological Process lipopolysaccharide-mediated signaling pathway involved_in IEA
GO:0071888 Biological Process macrophage apoptotic process involved_in TAS
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IEA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IEA
GO:0032727 Biological Process positive regulation of interferon-alpha production involved_in ISS
GO:0032728 Biological Process positive regulation of interferon-beta production involved_in ISS
GO:0032728 Biological Process positive regulation of interferon-beta production involved_in TAS
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IMP
GO:0032481 Biological Process positive regulation of type I interferon production involved_in IDA
GO:0060340 Biological Process positive regulation of type I interferon-mediated signaling pathway involved_in IEA
GO:0097300 Biological Process programmed necrotic cell death involved_in IEA
GO:0042981 Biological Process regulation of apoptotic process involved_in IDA
GO:0050727 Biological Process regulation of inflammatory response involved_in IEA
GO:0006357 Biological Process regulation of transcription by RNA polymerase II involved_in IBA
GO:0060337 Biological Process type I interferon-mediated signaling pathway involved_in IEA
GO:0000785 Cellular Component chromatin part_of IDA
GO:0000785 Cellular Component chromatin part_of ISA
GO:0005737 Cellular Component cytoplasm is_active_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IGI
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus is_active_in IDA
GO:0005634 Cellular Component nucleus located_in IDA
Pathways
Name DB ID
ISG15 antiviral mechanism Reactome R-HSA-1169408
Antiviral mechanism by IFN-stimulated genes Reactome R-HSA-1169410
Cytokine Signaling in Immune system Reactome R-HSA-1280215
ZBP1(DAI) mediated induction of type I IFNs Reactome R-HSA-1606322
IRF3 mediated activation of type 1 IFN Reactome R-HSA-1606341
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
STING mediated induction of host immune responses Reactome R-HSA-1834941
Cytosolic sensors of pathogen-associated DNA Reactome R-HSA-1834949
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome R-HSA-3134973
Regulation of innate immune responses to cytosolic DNA Reactome R-HSA-3134975
IRF3-mediated induction of type I IFN Reactome R-HSA-3270619
Infectious disease Reactome R-HSA-5663205
Interferon gamma signaling Reactome R-HSA-877300
TICAM1-dependent activation of IRF3/IRF7 Reactome R-HSA-9013973
Interferon alpha/beta signaling Reactome R-HSA-909733
Interferon Signaling Reactome R-HSA-913531
TRAF3-dependent IRF activation pathway Reactome R-HSA-918233
TRAF6 mediated IRF7 activation Reactome R-HSA-933541
Negative regulators of DDX58/IFIH1 signaling Reactome R-HSA-936440
Activation of IRF3, IRF7 mediated by TBK1, IKBKE Reactome R-HSA-936964
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
SARS-CoV-1 Infection Reactome R-HSA-9678108
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-1-host interactions Reactome R-HSA-9692914
SARS-CoV-1 activates/modulates innate immune responses Reactome R-HSA-9692916
SARS-CoV-2 Infection Reactome R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
SARS-CoV-2-host interactions Reactome R-HSA-9705683
Viral Infection Pathways Reactome R-HSA-9824446
mRNA vaccine activation of dendritic cell and induction of IFN-1 (WP5187) WikiPathways WP5187_r122433
TLR4 signaling and tolerance (WP3851) WikiPathways WP3851_r121712
Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
White fat cell differentiation (WP4149) WikiPathways WP4149_r107159
Measles virus infection (WP4630) WikiPathways WP4630_r123414
Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
STING pathway in Kawasaki-like disease and COVID-19 (WP4961) WikiPathways WP4961_r123345
Toll-like receptor signaling related to MyD88 (WP3858) WikiPathways WP3858_r117850
SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (WP5116) WikiPathways WP5116_r124652
SARS coronavirus and innate immunity (WP4912) WikiPathways WP4912_r124650
Type I interferon induction and signaling during SARS-CoV-2 infection (WP4868) WikiPathways WP4868_r124657
SARS-CoV-2 innate immunity evasion and cell-specific immune response (WP5039) WikiPathways WP5039_r124653
Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
Mitochondrial immune response to SARS-CoV-2 (WP5038) WikiPathways WP5038_r124641
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway (WP5113) WikiPathways WP5113_r124660
Apoptosis (WP254) WikiPathways WP254_r118382
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
Host-pathogen interaction of human coronaviruses - interferon induction (WP4880) WikiPathways WP4880_r124638
Fibrin complement receptor 3 signaling pathway (WP4136) WikiPathways WP4136_r120387
Ebola virus infection in host (WP4217) WikiPathways WP4217_r120623
Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
Pathways of nucleic acid metabolism and innate immune sensing (WP4705) WikiPathways WP4705_r123423
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_045568 2 miscRNA transcript variant 9 NC_000019 Reference
XR_007066794 1 miscRNA transcript variant X8 NC_000019 Reference
XR_007066795 1 miscRNA transcript variant X9 NC_000019 Reference
XM_047438784 1 mRNA transcript variant X13 NC_000019 Reference
XM_017026767 2 mRNA transcript variant X4 NC_000019 Reference
XM_006723198 2 mRNA transcript variant X2 NC_000019 Reference
XM_024451495 2 mRNA transcript variant X11 NC_000019 Reference
XM_017026766 2 mRNA transcript variant X3 NC_000019 Reference
XM_006723197 1 mRNA transcript variant X1 NC_000019 Reference
NM_001197128 2 mRNA transcript variant 8 NC_000019 Reference
NM_001197126 2 mRNA transcript variant 6 NC_000019 Reference
NM_001197127 2 mRNA transcript variant 7 NC_000019 Reference
NM_001197125 2 mRNA transcript variant 5 NC_000019 Reference
XM_006723201 2 mRNA transcript variant X12 NC_000019 Reference
XM_047438785 1 mRNA transcript variant X14 NC_000019 Reference
XM_024451494 2 mRNA transcript variant X10 NC_000019 Reference
NM_001197123 2 mRNA transcript variant 3 NC_000019 Reference
NM_001197124 2 mRNA transcript variant 4 NC_000019 Reference
NM_001571 6 mRNA transcript variant 1 NC_000019 Reference
NM_001197122 2 mRNA transcript variant 2 NC_000019 Reference
XM_006723200 2 mRNA transcript variant X5 NC_000019 Reference
XM_047438783 1 mRNA transcript variant X7 NC_000019 Reference
XM_047438782 1 mRNA transcript variant X6 NC_000019 Reference