MALAT1

metastasis associated lung adenocarcinoma transcript 1

General Information

Name	metastasis associated lung adenocarcinoma transcript 1
Alias	hepcarcin long intergenic non-protein coding RNA 47 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) nuclear enriched abundant transcript 2 nuclear paraspeckle assembly transcript 2 (non-protein coding)
Gene_family	Long non-coding RNAs with non-systematic symbols
organism	Homo sapiens
entrez_id	378938
location	11q13.1
transcript_count	3
exon_count	2

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]

Interactions

NCBI

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MALAT1	BioGRID	HNRNPUL2	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	HNRNPA3	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	SERPINB12	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	H2BC12	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	H2AC12	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	LAS1L	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	TRIM56	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	FIP1L1	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	POF1B	GeneID	BioGRID	Affinity Capture-MS
MALAT1	BioGRID	NOC4L	GeneID	BioGRID	Affinity Capture-MS

Showing 1 to 10 of 133 entries

StringDB

A	B	experiments	database	textmining	combined score	hadb	nhadb

Ontologies

ID	Category	Term	Effect	Evidence
GO:0140869	Molecular Function	miRNA inhibitor activity via base-pairing	enables	IDA
GO:0071456	Biological Process	cellular response to hypoxia	involved_in	IMP
GO:0000512	Biological Process	lncRNA-mediated post-transcriptional gene silencing	involved_in	IDA
GO:0110024	Biological Process	positive regulation of cardiac muscle myoblast proliferation	involved_in	IMP
GO:2000147	Biological Process	positive regulation of cell motility	involved_in	IEA
GO:2000627	Biological Process	positive regulation of miRNA catabolic process	involved_in	IDA
GO:0005634	Cellular Component	nucleus	located_in	IDA

Pathways

Name	DB	ID

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NR_002819	4	ncRNA	transcript variant 1	NC_000011	Reference
NR_144567	1	ncRNA	transcript variant 2	NC_000011	Reference
NR_144568	1	ncRNA	transcript variant 3	NC_000011	Reference