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ASIC1

acid sensing ion channel subunit 1
General Information
Name acid sensing ion channel subunit 1
Alias
  • acid-sensing ion channel 1
  • Cation channel, amiloride-sensitive, neuronal, 2
  • acid sensing (proton gated) ion channel 1
  • acid-sensing ion channel 1a protein
  • amiloride-sensitive cation channel 2, neuronal
  • brain sodium channel 2
Gene_family Acid sensing ion channel subunits
organism Homo sapiens
entrez_id 41
location 12q13.12
transcript_count 13
exon_count 16
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
    Stringdb Acid-sensing ion channel 1; Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry [...]
    nextProt Can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
ASIC1 BioGRID CANX GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID RHOF GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID CLEC4D GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID POM121C GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID DUOXA2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID MBLAC2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID C15orf32 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID B3GAT2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID TMPRSS11B GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ERMP1 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID TCTN2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID NCEH1 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID APOM GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID KLK15 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ASIC4 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID UFSP2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ODR4 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID PILRB GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ST8SIA5 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID CNNM3 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID SDF2L1 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID SEC11A GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID P2RX2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID SLC27A3 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID PICK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
ASIC1 BioGRID TNFRSF10B GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID B3GALT4 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID UPK2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID SFTPC GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID P2RX1 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ROR2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID HMOX2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID HLA-G GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID HLA-DRB3 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID HLA-C GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID GP9 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID EP300 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID DPEP1 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID CLPTM1 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ENTPD2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID ASIC2 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID DHFR2 GeneID BioGRID Proximity Label-MS
ASIC1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
ASIC1 BioGRID RAB11A GeneID BioGRID Proximity Label-MS
ASIC1 BioGRID RAB2A GeneID BioGRID Proximity Label-MS
ASIC1 BioGRID ARF6 GeneID BioGRID Proximity Label-MS
ASIC1 BioGRID KIR3DL3 GeneID BioGRID Two-hybrid
ASIC1 BioGRID MGST2 GeneID BioGRID Two-hybrid
ASIC1 BioGRID EIF2AK3 GeneID BioGRID Affinity Capture-MS
ASIC1 BioGRID TCTN3 GeneID BioGRID Proximity Label-MS
ASIC1 BioGRID STOM GeneID BioGRID Affinity Capture-Western
ASIC1 BioGRID ATXN3 GeneID BioGRID Two-hybrid
ASIC1 Protein PICK1 GeneID HPRD
ASIC1 Protein ASIC1 GeneID HPRD
ASIC1 Protein ASIC2 GeneID HPRD
ASIC1 Protein PRKACA GeneID HPRD
ASIC1 Protein STOM GeneID HPRD
ASIC1 BioGRID PRKACA GeneID BioGRID Biochemical Activity
ASIC1 Protein PICK1 GeneID BIND PICK1 interacts with ASIC.
StringDB
A B experiments database textmining combined score hadb nhadb
ASIC1 TMC1 0 0 123 206 1 1
ASIC1 DPP4 0 0 0 176 1 1
ASIC1 NR3C2 0 0 123 184 1 1
ASIC1 RAI2 0 0 202 202 1 1
ASIC1 DRD2 0 0 71 164 1 1
ASIC1 KLHL1 0 0 0 238 1 1
ASIC1 DIP2A 0 0 0 202 1 1
ASIC1 HTR1A 0 0 150 189 1 1
ASIC1 ATP10A 0 0 432 432 1 1
ASIC1 ART3 0 0 134 268 1 1
ASIC1 PCDH15 0 0 67 167 1 1
ASIC1 HIST1H4E 0 0 324 334 1 1
ASIC1 KCNIP3 0 0 0 161 1 1
ASIC1 SLC37A2 0 0 156 155 1 1
ASIC1 SYBU 0 0 44 265 1 1
ASIC1 ELFN2 0 0 0 177 1 1
ASIC1 KCNC4 0 0 134 233 1 1
ASIC1 PRPH2 0 0 327 327 1 1
ASIC1 PKD1L2 0 0 143 449 1 1
ASIC1 SCG2 0 0 390 431 1 1
ASIC1 KCNJ13 0 0 123 177 1 1
ASIC1 ADRA2A 0 0 165 202 1 1
ASIC1 TRPM4 0 0 328 332 1 1
ASIC1 PHACTR1 0 0 0 269 1 1
ASIC1 CACNG7 0 0 0 153 1 1
ASIC1 OR6A2 0 0 193 193 1 1
ASIC1 HVCN1 0 0 139 229 1 1
ASIC1 OPRL1 0 0 53 160 1 1
ASIC1 HAPLN2 0 0 0 161 1 1
ASIC1 KNG1 0 0 193 193 1 1
ASIC1 SGK2 0 0 537 547 1 1
ASIC1 MTSS1L 0 0 0 214 1 1
ASIC1 SPTBN4 0 0 90 206 1 1
ASIC1 FAP 0 0 0 176 1 2
ASIC1 ITGB1 0 0 457 457 1 1
ASIC1 PVALB 0 0 70 150 1 1
ASIC1 SLC52A3 0 0 42 186 1 1
ASIC1 SNPH 0 0 0 159 1 1
ASIC1 LHX5 0 0 90 156 1 1
ASIC1 CSPG5 0 0 0 205 1 1
ASIC1 SNRPN 0 0 607 615 1 1
ASIC1 CRHR1 0 0 125 217 1 1
ASIC1 DICER1 0 0 114 159 1 1
ASIC1 TBC1D5 0 0 0 284 1 2
ASIC1 C1QL1 0 0 0 176 1 1
ASIC1 NEK9 0 0 75 156 1 1
ASIC1 TRPC6 0 0 134 225 1 1
ASIC1 KCNJ16 0 0 113 196 1 1
ASIC1 DOPEY1 0 0 164 163 1 1
ASIC1 SLC35F1 0 0 130 212 1 1
ASIC1 ITPR1 0 0 137 156 1 2
ASIC1 RAC3 0 0 0 168 1 2
ASIC1 CTXN1 0 0 0 230 1 1
ASIC1 SLIT1 0 0 0 264 1 1
ASIC1 CD59 0 0 53 152 1 1
ASIC1 PPFIA3 0 0 0 202 1 1
ASIC1 NRXN2 0 0 108 202 1 1
ASIC1 ASIC5 0 600 654 678 1 1
ASIC1 GAK 0 0 74 319 1 1
ASIC1 PEX5 0 0 74 198 1 1
ASIC1 NANOS3 0 0 84 182 1 1
ASIC1 ADAM11 0 0 0 221 1 1
ASIC1 CALCA 0 0 180 296 1 1
ASIC1 TRPM8 0 0 408 448 1 1
ASIC1 ACTN2 0 0 0 177 1 1
ASIC1 PRSS8 0 0 96 158 1 1
ASIC1 RGS11 0 0 122 172 1 1
ASIC1 STIM2 0 0 82 218 1 1
ASIC1 VR1 0 0 607 693 1 1
ASIC1 MAPRE3 0 0 0 158 1 1
ASIC1 GJC2 0 0 0 184 1 1
ASIC1 NDUFS5 0 0 194 194 1 1
ASIC1 BHLHE23 0 0 113 282 1 1
ASIC1 P2RX7 0 0 142 219 1 2
ASIC1 KCNV1 0 0 46 161 1 1
ASIC1 GPD1L 0 0 0 234 1 1
ASIC1 TSPAN16 0 0 157 156 1 1
ASIC1 P2RX6 0 0 133 154 1 1
ASIC1 STOML2 0 0 0 166 1 1
ASIC1 P2RX5 0 0 341 378 1 1
ASIC1 TMEM39B 0 0 232 231 1 1
ASIC1 TRPC5 0 0 112 191 1 1
ASIC1 C11orf53 0 0 90 159 1 1
ASIC1 TRPM6 0 0 179 264 1 1
ASIC1 EEF1A2 0 0 0 171 1 1
ASIC1 P2RY1 0 0 283 298 1 1
ASIC1 SNX3 0 0 113 274 1 1
ASIC1 UCHL1 0 0 81 150 1 2
ASIC1 PPM1F 0 0 0 211 1 1
ASIC1 GJC3 0 0 95 292 1 1
ASIC1 NFATC3 0 0 124 193 1 1
ASIC1 HMX2 0 0 135 168 1 1
ASIC1 KCNK17 0 0 49 307 1 1
ASIC1 CADM4 0 0 0 171 1 1
ASIC1 NAT8L 0 0 0 231 1 1
ASIC1 SEPT5 0 0 0 157 1 1
ASIC1 RTN4R 0 0 54 156 1 1
ASIC1 SLC4A10 0 0 0 171 1 1
ASIC1 CERS5 0 0 193 334 1 1
ASIC1 RFC2 0 0 74 241 1 1
ASIC1 DPP9 0 0 0 155 1 1
ASIC1 KCNN1 0 0 127 219 1 1
ASIC1 KCNK3 0 0 283 406 1 1
ASIC1 TTC9B 0 0 0 155 1 1
ASIC1 SLC8A2 0 0 0 189 1 1
ASIC1 CNGA1 0 0 181 211 1 1
ASIC1 SCN3A 0 0 81 181 1 1
ASIC1 NXPH4 0 0 0 162 1 1
ASIC1 SNTG2 0 0 134 152 1 1
ASIC1 GPR31 0 0 48 194 1 1
ASIC1 SLC9A3 0 0 95 161 1 1
ASIC1 DPP6 0 0 0 176 1 1
ASIC1 PODXL2 0 0 0 181 1 1
ASIC1 GPRIN1 0 0 0 171 1 1
ASIC1 P2RX2 0 0 380 425 1 1
ASIC1 C2CD4C 0 0 0 154 1 1
ASIC1 PKD1L3 0 0 126 262 1 1
ASIC1 EPRS 0 0 95 163 1 1
ASIC1 ATP6V1G2 0 0 0 182 1 1
ASIC1 CAMK2N2 0 0 45 176 1 1
ASIC1 CACNB1 0 0 64 170 1 1
ASIC1 KCNT1 0 0 166 227 1 1
ASIC1 NEFH 0 0 96 224 1 1
ASIC1 LIMA1 0 0 150 341 1 1
ASIC1 KIR3DL3 255 0 0 254 1 1
ASIC1 FAT3 0 0 0 151 1 1
ASIC1 KCNF1 0 0 0 156 1 1
ASIC1 HIST1H4J 0 0 324 334 1 1
ASIC1 ARID4B 0 0 540 543 1 1
ASIC1 CSNK1E 0 0 0 164 1 1
ASIC1 EPCAM 0 0 157 156 1 2
ASIC1 SOX8 0 0 0 197 1 1
ASIC1 KCNH2 0 0 193 248 1 1
ASIC1 SPR 0 0 44 304 1 1
ASIC1 TPM1 0 0 0 192 1 1
ASIC1 STX1A 0 0 112 180 1 1
ASIC1 SCN7A 0 0 167 249 1 1
ASIC1 SYN1 0 0 0 191 1 1
ASIC1 FBXO38 0 0 0 284 1 1
ASIC1 ACAD8 0 0 241 268 1 1
ASIC1 NPSR1 0 0 266 266 1 1
ASIC1 BCR 0 0 329 329 1 2
ASIC1 TRPM5 0 0 109 174 1 1
ASIC1 ABCG4 0 0 0 153 1 1
ASIC1 OCA2 0 0 324 338 1 1
ASIC1 SOX9 0 0 0 150 1 1
ASIC1 TAS2R38 0 0 140 230 1 1
ASIC1 TMC2 0 0 48 230 1 1
ASIC1 GCOM1 0 0 184 235 1 1
ASIC1 ACAN 0 0 67 150 1 1
ASIC1 BRMS1L 0 0 398 398 1 1
ASIC1 NALCN 0 0 134 212 1 1
ASIC1 KCNA5 0 0 193 229 1 1
ASIC1 GRM8 0 0 67 153 1 1
ASIC1 KCNJ9 0 0 134 271 1 1
ASIC1 IL17D 0 0 0 151 1 1
ASIC1 KCNMA1 0 0 193 248 1 1
ASIC1 SYVN1 0 0 308 307 1 1
ASIC1 LIN7B 0 0 0 165 1 1
ASIC1 HIST1H4F 0 0 324 334 1 1
ASIC1 GRIP1 0 0 92 159 1 1
ASIC1 HCN2 0 0 202 585 1 1
ASIC1 CBY1 0 0 0 177 1 1
ASIC1 KCNH1 0 0 0 169 1 1
ASIC1 RPL13A 0 0 0 238 1 1
ASIC1 TRPV6 0 0 181 251 1 1
ASIC1 OLFM2 0 0 134 224 1 1
ASIC1 PRRT1 0 0 0 170 1 1
ASIC1 APP 0 0 90 169 1 2
ASIC1 DCAF6 0 0 0 154 1 1
ASIC1 SCN1A 0 0 233 263 1 1
ASIC1 TRPV1 0 0 607 693 1 2
ASIC1 SLC5A7 0 0 81 238 1 1
ASIC1 TMEM240 0 0 0 151 1 1
ASIC1 HCN4 0 0 0 251 1 1
ASIC1 CACNA1C 0 0 171 220 1 1
ASIC1 CACNA2D2 0 0 113 183 1 1
ASIC1 TRPM7 0 0 134 273 1 1
ASIC1 RTN4RL1 0 0 114 281 1 1
ASIC1 NEDD4 0 0 90 170 1 2
ASIC1 ID1 0 0 81 176 1 1
ASIC1 RAB6B 0 0 45 161 1 1
ASIC1 KCNQ1 0 0 170 204 1 1
ASIC1 UBE2G1 0 0 539 539 1 1
ASIC1 DIP2B 0 0 173 311 1 1
ASIC1 SLC6A5 0 0 0 173 1 1
ASIC1 KCNC1 0 0 154 261 1 1
ASIC1 TRPC3 0 0 142 261 1 1
ASIC1 GAPDH 0 0 134 175 1 2
ASIC1 CA14 0 0 151 263 1 1
ASIC1 BRSK2 0 0 0 196 1 1
ASIC1 SLC38A5 0 0 0 189 1 1
ASIC1 KCNB1 0 0 144 220 1 2
ASIC1 HIST4H4 0 0 324 334 1 1
ASIC1 BCCIP 0 0 128 170 1 1
ASIC1 SLC9A1 0 0 134 267 1 1
ASIC1 CHRNA4 0 0 0 160 1 1
ASIC1 PCLO 0 0 141 207 1 1
ASIC1 NDUFA12 0 0 0 252 1 1
ASIC1 KCNK1 0 0 140 228 1 1
ASIC1 CLCN2 0 0 188 239 1 1
ASIC1 CLCF1 0 0 90 183 1 1
ASIC1 UNC13C 0 0 0 170 1 1
ASIC1 GRIA2 0 0 52 262 1 1
ASIC1 PIANP 0 0 0 151 1 1
ASIC1 SLC25A6 0 0 0 189 1 1
ASIC1 TRPC1 0 0 340 384 1 1
ASIC1 TMEM199 0 0 66 180 1 1
ASIC1 LRRC4B 0 0 0 155 1 1
ASIC1 NCS1 0 0 108 258 1 1
ASIC1 CACNG1 0 0 137 187 1 1
ASIC1 GRIK2 0 0 194 239 1 1
ASIC1 SCNN1D 0 0 409 239 1 1
ASIC1 SIAH1 0 0 57 225 1 1
ASIC1 PLK1 0 0 340 340 1 2
ASIC1 SLC4A7 0 0 101 159 1 1
ASIC1 GPD1 0 0 96 583 1 1
ASIC1 TMEM198 0 0 0 157 1 1
ASIC1 PIEZO2 0 0 457 489 1 1
ASIC1 PRKACA 270 0 0 294 1 1
ASIC1 ATP1A3 0 0 0 151 1 1
ASIC1 KCNC3 0 0 126 198 1 1
ASIC1 UROD 0 0 397 396 1 1
ASIC1 GPR18 0 0 75 152 1 1
ASIC1 TAS2R9 0 0 0 153 1 1
ASIC1 NDN 0 0 351 365 1 1
ASIC1 LMTK3 0 0 0 193 1 1
ASIC1 LNPEP 0 0 86 236 1 1
ASIC1 FURIN 0 0 142 248 1 1
ASIC1 GLRB 0 0 134 216 1 1
ASIC1 RTN4RL2 0 0 120 214 1 1
ASIC1 B4GALNT1 0 0 0 220 1 1
ASIC1 LRRTM3 0 0 150 198 1 1
ASIC1 HIST1H4L 0 0 324 334 1 1
ASIC1 JPH3 0 0 0 159 1 1
ASIC1 MTA1 0 0 297 322 1 1
ASIC1 RIMS4 0 0 0 156 1 1
ASIC1 SLC6A7 0 0 0 197 1 1
ASIC1 FBXL16 0 0 0 170 1 1
ASIC1 KCNN3 0 0 91 166 1 1
ASIC1 TMEM132D 0 0 204 221 1 1
ASIC1 ZFP57 0 0 442 450 1 1
ASIC1 STOML1 0 0 181 408 1 1
ASIC1 NTS 0 0 0 157 1 1
ASIC1 SCN2A 0 0 206 310 1 1
ASIC1 RUVBL2 0 0 0 200 1 1
ASIC1 PHYHIP 0 0 164 314 1 1
ASIC1 ADORA1 0 0 49 180 1 1
ASIC1 CERS1 0 0 0 185 1 1
ASIC1 COX14 0 0 252 252 1 1
ASIC1 NCAN 0 0 108 243 1 1
ASIC1 USP10 0 0 0 169 1 1
ASIC1 KCNC2 0 0 167 376 1 1
ASIC1 POLR2G 0 0 0 258 1 1
ASIC1 GPR151 0 0 53 310 1 1
ASIC1 HTR1B 0 0 160 265 1 1
ASIC1 APC2 0 0 0 194 1 1
ASIC1 PPIP5K1 0 0 74 171 1 1
ASIC1 SLC6A4 0 0 150 198 1 1
ASIC1 NLGN2 0 0 0 173 1 1
ASIC1 PLTP 0 0 70 152 1 1
ASIC1 TPH1 0 0 107 205 1 1
ASIC1 MGST2 256 0 0 256 1 1
ASIC1 KCND3 0 0 89 164 1 1
ASIC1 NR2F1 0 0 0 151 1 1
ASIC1 MUC5AC 0 0 0 200 1 1
ASIC1 DYNLL1 0 0 0 188 1 1
ASIC1 SLC14A2 0 0 0 258 1 1
ASIC1 B4GALT6 0 0 154 153 1 1
ASIC1 CLCN5 0 0 93 190 1 1
ASIC1 GDNF 0 0 174 174 1 2
ASIC1 SCNN1G 0 0 340 336 1 1
ASIC1 KIAA1217 0 0 0 303 1 1
ASIC1 SEMA3C 0 0 0 189 1 1
ASIC1 SCNN1B 0 0 358 275 1 1
ASIC1 DIRAS1 0 0 0 194 1 1
ASIC1 SLC7A4 0 0 283 282 1 1
ASIC1 CHRNA3 0 0 44 151 1 1
ASIC1 CALM3 0 0 66 156 1 1
ASIC1 P2RX4 0 0 456 515 1 1
ASIC1 MUC5B 0 0 46 204 1 1
ASIC1 BRSK1 0 0 0 230 1 1
ASIC1 RBL1 0 0 294 294 1 1
ASIC1 SLC9A3R2 0 0 0 172 1 1
ASIC1 PRPH 0 0 245 276 1 1
ASIC1 HDAC2 0 0 310 309 1 1
ASIC1 PLP1 0 0 45 156 1 1
ASIC1 KRT2 0 0 90 182 1 1
ASIC1 DOCK3 0 0 95 190 1 1
ASIC1 COL9A3 0 0 75 162 1 1
ASIC1 CFTR 0 0 162 214 1 2
ASIC1 SCN10A 0 0 391 484 1 1
ASIC1 GPM6B 0 0 112 152 1 1
ASIC1 PCDHA6 0 0 164 194 1 1
ASIC1 HIST1H4I 0 0 324 334 1 1
ASIC1 HTT 0 0 0 177 1 2
ASIC1 KCNK4 0 0 135 380 1 1
ASIC1 RNF128 0 0 0 302 1 1
ASIC1 PIEZO1 0 0 395 431 1 1
ASIC1 GFRA1 0 0 180 203 1 1
ASIC1 GFAP 0 0 0 186 1 2
ASIC1 GRK6 0 0 108 229 1 1
ASIC1 PLXNB3 0 0 0 151 1 1
ASIC1 SMIM14 0 0 218 218 1 1
ASIC1 CABLES2 0 0 66 184 1 1
ASIC1 NPAP1 0 0 282 282 1 1
ASIC1 TAC1 0 0 181 327 1 1
ASIC1 FAIM2 0 0 91 212 1 1
ASIC1 DLG4 0 0 92 361 1 2
ASIC1 EPHA6 0 0 0 241 1 1
ASIC1 SEPT3 0 0 0 150 1 1
ASIC1 POLR3H 0 0 209 213 1 1
ASIC1 PON2 0 0 0 180 1 1
ASIC1 CDH10 0 0 0 176 1 1
ASIC1 KCNK2 0 0 286 371 1 1
ASIC1 GPR132 0 0 90 187 1 1
ASIC1 BRMS1 0 0 398 398 1 1
ASIC1 CASKIN2 0 0 180 239 1 1
ASIC1 KCNA3 0 0 215 304 1 1
ASIC1 CLCN3 0 0 127 185 1 1
ASIC1 KCNA2 0 0 284 352 1 1
ASIC1 NXPH1 0 0 113 195 1 1
ASIC1 ARTN 0 0 195 209 1 1
ASIC1 RCHY1 0 0 0 189 1 1
ASIC1 HIST1H4K 0 0 324 334 1 1
ASIC1 HIST1H4A 0 0 323 333 1 1
ASIC1 NPY1R 0 0 90 165 1 1
ASIC1 B4GALNT4 0 0 0 181 1 1
ASIC1 PKD2L1 0 0 184 323 1 1
ASIC1 MRPL35 0 0 194 507 1 1
ASIC1 MAK 0 0 0 232 1 1
ASIC1 FAM171A2 0 0 0 196 1 1
ASIC1 NTRK3 0 0 183 227 1 1
ASIC1 FTSJ3 0 0 0 360 1 1
ASIC1 STOML3 0 600 54 783 1 1
ASIC1 PVRL1 0 0 0 189 1 1
ASIC1 GPR68 0 0 57 313 1 1
ASIC1 TRPV3 0 0 298 341 1 1
ASIC1 KCNJ12 0 0 0 169 1 1
ASIC1 SLC6A3 0 0 242 284 1 1
ASIC1 SPX 0 0 134 152 1 1
ASIC1 CAMK1 0 0 0 207 1 1
ASIC1 GRIN1 0 0 0 266 1 1
ASIC1 ECHDC3 0 0 0 194 1 1
ASIC1 TRPA1 0 0 460 543 1 1
ASIC1 P2RY2 0 0 180 197 1 1
ASIC1 SEZ6L2 0 0 0 163 1 1
ASIC1 MPP2 0 0 0 173 1 1
ASIC1 NCL 0 0 171 171 1 2
ASIC1 GPR149 0 0 144 307 1 1
ASIC1 ADAMTS14 0 0 141 156 1 1
ASIC1 KCNS1 0 0 74 166 1 1
ASIC1 CDH9 0 0 0 272 1 1
ASIC1 LARP4 0 0 234 362 1 1
ASIC1 KCNA4 0 0 75 223 1 1
ASIC1 CASR 0 0 43 153 1 2
ASIC1 DYNLL2 0 0 0 217 1 1
ASIC1 NCAM2 0 0 0 310 1 1
ASIC1 PRKCA 0 0 113 312 1 1
ASIC1 CAMK2A 0 0 351 382 1 2
ASIC1 NCAM1 0 0 0 154 1 1
ASIC1 PSD3 0 0 0 213 1 1
ASIC1 SMG6 0 0 74 161 1 1
ASIC1 FAM178A 0 0 158 157 1 1
ASIC1 GUCY1A2 0 0 0 237 1 1
ASIC1 ICK 0 0 0 232 1 1
ASIC1 RAB3A 0 0 0 168 1 1
ASIC1 LAMC3 0 0 0 175 1 1
ASIC1 KCNN4 0 0 397 410 1 1
ASIC1 CLCC1 0 0 299 607 1 1
ASIC1 IVD 0 0 0 205 1 1
ASIC1 KCNK10 0 0 181 348 1 1
ASIC1 SNCB 0 0 0 177 1 1
ASIC1 SCNN1A 0 0 327 319 1 1
ASIC1 KCNK18 0 0 184 317 1 1
ASIC1 GJC1 0 0 0 224 1 1
ASIC1 APLP1 0 0 0 193 1 1
ASIC1 PON1 0 0 0 191 1 1
ASIC1 SNRPB 0 0 167 177 1 1
ASIC1 ADAM15 0 0 0 153 1 1
ASIC1 CACNA1I 0 0 113 164 1 1
ASIC1 GFRA3 0 0 0 206 1 1
ASIC1 SULT4A1 0 0 45 189 1 1
ASIC1 STXBP1 0 0 0 156 1 1
ASIC1 EEF2K 0 0 0 154 1 2
ASIC1 STOM 270 600 134 802 1 1
ASIC1 NTSR2 0 0 0 160 1 1
ASIC1 MAPK11 0 0 0 167 1 1
ASIC1 PEA15 0 0 95 157 1 1
ASIC1 KRTAP4-7 0 0 218 218 1 1
ASIC1 BCAN 0 0 74 251 1 1
ASIC1 ANKRD13B 0 0 0 172 1 1
ASIC1 CERS6 0 0 75 237 1 1
ASIC1 ORAI3 0 0 0 155 1 1
ASIC1 GRIN2B 0 0 81 215 1 1
ASIC1 ATXN3 192 0 0 225 1 2
ASIC1 PICK1 678 0 828 979 1 1
ASIC1 PHB 0 0 0 209 1 1
ASIC1 ADCYAP1R1 0 0 103 179 1 1
ASIC1 GABBR1 0 0 134 201 1 1
ASIC1 SLC48A1 0 0 166 165 1 1
ASIC1 SLC26A10 0 0 60 168 1 1
ASIC1 SCN8A 0 0 315 378 1 1
ASIC1 SIGMAR1 0 0 64 473 1 1
ASIC1 CLIC1 0 0 90 164 1 1
ASIC1 TTLL4 0 0 0 250 1 1
ASIC1 P2RX3 0 0 406 487 1 1
ASIC1 COLCA2 0 0 81 173 1 1
ASIC1 PITPNM3 0 0 146 203 1 1
ASIC1 SLC23A2 0 0 82 197 1 1
ASIC1 ATAT1 0 0 95 228 1 1
ASIC1 SLC45A3 0 0 81 469 1 1
ASIC1 DCDC2 0 0 0 185 1 1
ASIC1 TNFRSF10B 182 0 0 181 1 2
ASIC1 SUDS3 0 0 414 414 1 1
ASIC1 RASGRF1 0 0 0 155 1 1
ASIC1 BRINP3 0 0 113 192 1 1
ASIC1 DLG3 0 0 66 187 1 1
ASIC1 GPR65 0 0 193 288 1 1
ASIC1 TMEM59L 0 0 0 211 1 1
ASIC1 TRPC4 0 0 280 361 1 1
ASIC1 DPEP1 179 0 0 181 1 1
ASIC1 KCNQ2 0 0 216 372 1 1
ASIC1 RIMS3 0 0 120 240 1 1
ASIC1 S100B 0 0 81 164 1 1
ASIC1 FOLH1 0 0 261 261 1 1
ASIC1 TRPM3 0 0 320 340 1 1
ASIC1 SPOCK3 0 0 127 158 1 1
ASIC1 CACNA1H 0 0 170 225 1 1
ASIC1 HIST2H4A 0 0 324 334 1 1
ASIC1 TMEM106B 0 0 0 302 1 1
ASIC1 SCN4B 0 0 142 264 1 1
ASIC1 SNURF 0 0 518 518 1 1
ASIC1 RACGAP1 0 0 66 651 1 1
ASIC1 KCNK16 0 0 150 381 1 1
ASIC1 PHB2 0 0 0 155 1 1
ASIC1 TRPV5 0 0 261 340 1 1
ASIC1 LRRC73 0 0 0 151 1 1
ASIC1 HDAC1 0 0 266 266 1 2
ASIC1 KCNJ10 0 0 120 182 1 1
ASIC1 ALDH6A1 0 0 0 260 1 1
ASIC1 GAD1 0 0 83 180 1 1
ASIC1 CASKIN1 0 0 0 152 1 1
ASIC1 KRTAP5-4 0 0 181 181 1 1
ASIC1 SYT3 0 0 0 156 1 1
ASIC1 GSG1 0 0 247 263 1 1
ASIC1 PKD1 0 0 95 161 1 1
ASIC1 SLC25A5 0 0 0 189 1 1
ASIC1 SIN3B 0 0 411 410 1 1
ASIC1 F2 0 0 0 202 1 1
ASIC1 ORAI2 0 0 107 309 1 1
ASIC1 KRT73 0 0 217 259 1 1
ASIC1 FAM131C 0 0 0 165 1 1
ASIC1 TRPV2 0 0 380 445 1 1
ASIC1 ENSG00000279890 0 0 145 450 1 1
ASIC1 TRPV4 0 0 457 486 1 1
ASIC1 CDKL5 0 0 0 189 1 1
ASIC1 ASIC3 0 600 916 662 1 1
ASIC1 RASGRF2 0 0 0 277 1 1
ASIC1 KCNV2 0 0 112 249 1 1
ASIC1 DPP8 0 0 0 155 1 1
ASIC1 TPRA1 0 0 0 292 1 1
ASIC1 CSN3 0 0 155 154 1 1
ASIC1 TINAGL1 0 0 106 161 1 1
ASIC1 MRVI1 0 0 0 188 1 1
ASIC1 P2RX1 0 0 282 296 1 1
ASIC1 KCNN2 0 0 108 182 1 1
ASIC1 ZNF488 0 0 0 166 1 1
ASIC1 HIST1H4D 0 0 324 334 1 1
ASIC1 CACNA1A 0 0 113 168 1 1
ASIC1 PEG3 0 0 307 317 1 2
ASIC1 ARHGAP26 0 0 82 225 1 1
ASIC1 SCN5A 0 0 216 265 1 1
ASIC1 KIAA1033 0 0 214 214 1 1
ASIC1 KCNAB2 0 0 169 270 1 1
ASIC1 AQR 0 0 108 169 1 1
ASIC1 CACNG8 0 0 150 333 1 1
ASIC1 NTRK2 0 0 120 215 1 1
ASIC1 CDH6 0 0 0 151 1 1
ASIC1 HUS1 0 0 57 156 1 1
ASIC1 CD4 0 0 317 317 1 2
ASIC1 WDTC1 0 0 0 154 1 1
ASIC1 ARHGAP20 0 0 0 157 1 1
ASIC1 PRKCG 0 0 0 188 1 1
ASIC1 SCN9A 0 0 287 352 1 1
ASIC1 SGK3 0 0 515 525 1 1
ASIC1 DIP2C 0 0 0 231 1 1
ASIC1 KCNJ5 0 0 81 163 1 1
ASIC1 GRIK1 0 0 147 193 1 1
ASIC1 HIST1H4C 0 0 324 334 1 1
ASIC1 UBE3A 0 0 369 409 1 1
ASIC1 MAGEL2 0 0 412 433 1 1
ASIC1 BRINP2 0 0 0 222 1 1
ASIC1 KRT33A 0 0 157 215 1 1
ASIC1 KCNJ1 0 0 203 232 1 1
ASIC1 TH 0 0 120 153 1 2
ASIC1 FBXO25 0 0 0 217 1 1
ASIC1 GPR64 0 0 112 187 1 1
ASIC1 ENSG00000274276 0 0 0 158 1 1
ASIC1 NGF 0 0 241 318 1 2
ASIC1 NKX2-8 0 0 101 162 1 1
ASIC1 ILF2 0 0 0 207 1 1
ASIC1 MRGPRD 0 0 167 348 1 1
ASIC1 PPM1E 0 0 0 159 1 1
ASIC1 PKD2 0 0 112 265 1 2
ASIC1 MDGA2 0 0 0 315 1 1
ASIC1 TPM3 0 0 0 192 1 1
ASIC1 GRM5 0 0 0 150 1 1
ASIC1 FAAH 0 0 145 184 1 1
ASIC1 CCK 0 0 74 178 1 1
ASIC1 BSND 0 0 163 190 1 1
ASIC1 KCNJ2 0 0 181 246 1 1
ASIC1 BMP8B 0 0 432 436 1 1
ASIC1 GDF1 0 0 0 187 1 1
ASIC1 NEDD4L 0 0 124 247 1 1
ASIC1 RHEBL1 0 0 134 151 1 1
ASIC1 EPB41L1 0 0 0 156 1 1
ASIC1 AGTPBP1 0 0 0 206 1 1
ASIC1 CDK5R2 0 0 0 151 1 1
ASIC1 CNR1 0 0 108 175 1 1
ASIC1 SCN4A 0 0 88 164 1 1
ASIC1 MGAT5B 0 0 0 171 1 1
ASIC1 SLC17A8 0 0 125 164 1 1
ASIC1 HECW1 0 0 109 250 1 1
ASIC1 TMEM150C 0 0 206 626 1 1
ASIC1 CNIH2 0 0 0 158 1 1
ASIC1 PIK3C2G 0 0 0 261 1 1
ASIC1 BYSL 0 0 0 216 1 1
ASIC1 LAMC1 0 0 0 175 1 1
ASIC1 HIST1H4H 0 0 324 334 1 1
ASIC1 CACNG2 0 0 95 198 1 1
ASIC1 KCNK13 0 0 158 163 1 1
ASIC1 HCN3 0 0 181 348 1 1
ASIC1 MKRN3 0 0 443 443 1 1
ASIC1 ASIC2 445 600 951 801 1 1
ASIC1 SYN2 0 0 66 156 1 1
ASIC1 PON3 0 0 0 294 1 1
ASIC1 GPR55 0 0 113 158 1 1
ASIC1 GPR4 0 0 60 305 1 1
ASIC1 ABI2 0 0 91 184 1 1
ASIC1 PRPF6 0 0 91 339 1 1
ASIC1 HTR2C 0 0 386 413 1 1
ASIC1 KCND2 0 0 0 153 1 1
ASIC1 SLC6A9 0 0 0 196 1 1
ASIC1 MTMR11 0 0 202 202 1 1
ASIC1 SCP2 0 0 0 160 1 1
ASIC1 KCNH5 0 0 150 225 1 1
ASIC1 SIN3A 0 0 413 412 1 1
ASIC1 BDNF 0 0 150 270 1 2
ASIC1 DPP10 0 0 0 176 1 1
ASIC1 PSD2 0 0 0 277 1 1
ASIC1 NYAP1 0 0 0 214 1 1
ASIC1 GABRG2 0 0 67 231 1 1
ASIC1 DNAJC6 0 0 0 165 1 1
ASIC1 STEAP2 0 0 112 330 1 1
ASIC1 ARHGEF25 0 0 0 199 1 1
ASIC1 ARID4A 0 0 538 541 1 1
ASIC1 SRRM3 0 0 0 171 1 1
ASIC1 S100A10 0 0 134 392 1 1
ASIC1 HTR3B 0 0 91 185 1 1
ASIC1 NPHS2 0 0 0 188 1 2
ASIC1 GRIA1 0 0 92 198 1 1
ASIC1 HPCA 0 0 0 174 1 1
ASIC1 MDGA1 0 0 0 167 1 1
ASIC1 HIST2H4B 0 0 324 334 1 1
ASIC1 KCNJ4 0 0 0 208 1 1
ASIC1 EVL 0 0 0 165 1 1
ASIC1 PCDHB1 0 0 60 175 1 1
ASIC1 HPRT1 0 0 67 261 1 1
ASIC1 CTLA4 0 0 255 255 1 2
ASIC1 PSD 0 0 0 473 1 1
ASIC1 HOXC12 0 0 103 169 1 1
ASIC1 KCND1 0 0 67 169 1 1
ASIC1 KCNK9 0 0 213 346 1 1
ASIC1 TAS2R3 0 0 66 161 1 1
ASIC1 AHNAK 0 0 96 239 1 1
ASIC1 SAP30 0 0 307 307 1 1
ASIC1 CACNA1B 0 0 118 204 1 1
ASIC1 APEH 0 0 0 175 1 1
ASIC1 ADRA2C 0 0 170 219 1 1
ASIC1 STIM1 0 0 154 193 1 2
ASIC1 NPY5R 0 0 134 191 1 1
ASIC1 ACTN1 0 0 49 153 1 1
ASIC1 ANXA2 0 0 120 254 1 1
ASIC1 KCNA1 0 0 167 240 1 1
ASIC1 SGK1 0 0 305 320 1 2
ASIC1 SCN11A 0 0 296 344 1 1
ASIC1 NTRK1 0 0 180 259 1 1
ASIC1 HIST1H4B 0 0 324 334 1 1
ASIC1 CPLX1 0 0 0 171 1 1
ASIC1 KCNQ4 0 0 103 246 1 1
ASIC1 RFWD2 0 0 0 158 1 1
ASIC1 TTBK1 0 0 0 206 1 1
ASIC1 SCRT1 0 0 0 151 1 1
ASIC1 DRP2 0 0 0 166 1 1
ASIC1 FXYD2 0 0 0 189 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0044736 Molecular Function acid-sensing ion channel activity enables IBA
GO:0044736 Molecular Function acid-sensing ion channel activity enables IDA
GO:0044736 Molecular Function acid-sensing ion channel activity enables ISS
GO:0015280 Molecular Function ligand-gated sodium channel activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0008306 Biological Process associative learning involved_in IEA
GO:0001662 Biological Process behavioral fear response involved_in IEA
GO:0070588 Biological Process calcium ion transmembrane transport involved_in IEA
GO:0071467 Biological Process cellular response to pH involved_in IDA
GO:0007613 Biological Process memory involved_in IEA
GO:0046929 Biological Process negative regulation of neurotransmitter secretion involved_in IEA
GO:0007269 Biological Process neurotransmitter secretion involved_in IEA
GO:0070207 Biological Process protein homotrimerization involved_in ISS
GO:0042391 Biological Process regulation of membrane potential involved_in IEA
GO:0010447 Biological Process response to acidic pH involved_in IEA
GO:0001975 Biological Process response to amphetamine involved_in IEA
GO:0009268 Biological Process response to pH involved_in TAS
GO:0050915 Biological Process sensory perception of sour taste involved_in IMP
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0035725 Biological Process sodium ion transmembrane transport involved_in IBA
GO:0035725 Biological Process sodium ion transmembrane transport involved_in IDA
GO:0035725 Biological Process sodium ion transmembrane transport involved_in ISS
GO:0006814 Biological Process sodium ion transport involved_in NAS
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0009986 Cellular Component cell surface located_in IEA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IMP
GO:0005886 Cellular Component plasma membrane located_in ISS
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0098793 Cellular Component presynapse located_in IEA
Pathways
Name DB ID
Stimuli-sensing channels Reactome R-HSA-2672351
Transport of small molecules Reactome R-HSA-382551
Ion channel transport Reactome R-HSA-983712
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_046389 2 miscRNA transcript variant 4 NC_000012 Reference
XM_011538350 2 mRNA transcript variant X1 NC_000012 Reference
XM_011538352 2 mRNA transcript variant X2 NC_000012 Reference
NM_001412756 1 mRNA transcript variant 5 NC_000012 Reference
NM_020039 4 mRNA transcript variant 1 NC_000012 Reference
NM_001095 4 mRNA transcript variant 2 NC_000012 Reference
NM_001412758 1 mRNA transcript variant 7 NC_000012 Reference
NM_001412757 1 mRNA transcript variant 6 NC_000012 Reference
NM_001412759 1 mRNA transcript variant 8 NC_000012 Reference
NM_001412761 1 mRNA transcript variant 10 NC_000012 Reference
NM_001412760 1 mRNA transcript variant 9 NC_000012 Reference
NM_001412762 1 mRNA transcript variant 11 NC_000012 Reference
NM_001256830 2 mRNA transcript variant 3 NC_000012 Reference