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MLN

motilin
General Information
Name motilin
Alias
  • promotilin
  • prepromotilin
Gene_family Neuropeptides
organism Homo sapiens
entrez_id 4295
location 6p21.31
transcript_count 3
exon_count 5
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]
    Stringdb Promotilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Endogenous ligands
    nextProt Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MLN BioGRID TTC19 GeneID BioGRID Two-hybrid
MLN BioGRID TMX2 GeneID BioGRID Two-hybrid
MLN Protein MLNR GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
MLN NPY 0 0 564 564 1 1
MLN GRPR 0 0 107 220 1 1
MLN GHRH 0 0 456 456 1 1
MLN IGF1 0 0 181 181 1 2
MLN PCSK1N 0 0 208 424 1 1
MLN GHSR 0 0 732 778 1 1
MLN AGT 0 300 0 300 1 1
MLN GCG 0 300 720 797 1 1
MLN ATP12A 0 0 424 437 1 1
MLN RSPH4A 0 0 486 485 1 1
MLN CHGA 0 0 270 437 1 1
MLN PDYN 0 0 323 323 1 1
MLN TAC3 0 300 139 410 1 1
MLN GH1 0 0 218 218 1 1
MLN AOC1 0 0 266 266 1 1
MLN NTSR2 0 0 150 203 1 1
MLN NOS1 0 0 157 156 1 1
MLN NMB 0 500 244 814 1 1
MLN ANXA1 0 500 0 499 1 1
MLN NTS 0 300 825 875 1 1
MLN GPR37L1 0 0 204 341 1 1
MLN IFITM1 0 0 464 463 1 1
MLN UTS2 0 500 0 499 1 1
MLN TNF 0 0 163 163 1 2
MLN MRPL15 0 0 107 171 1 1
MLN PPIP5K1 0 0 90 234 1 1
MLN UTS2B 0 500 46 502 1 1
MLN LEMD2 0 0 0 437 1 1
MLN PSAPL1 0 0 0 300 1 1
MLN SLC35F5 0 0 181 181 1 1
MLN XCL2 0 500 0 499 1 1
MLN GDNF 0 0 167 167 1 2
MLN CCKAR 0 0 261 261 1 1
MLN SSTR2 0 0 180 179 1 1
MLN PYCR1 0 0 158 157 1 1
MLN GIP 0 0 720 730 1 1
MLN EDN2 0 500 0 499 1 1
MLN MLNR 213 800 967 994 1 1
MLN PCSK5 0 0 310 309 1 1
MLN HCRT 0 300 285 493 1 1
MLN C2orf40 0 0 207 207 1 1
MLN RPGR 0 0 306 306 1 1
MLN BRS3 0 0 245 325 1 1
MLN CHGB 0 0 171 183 1 1
MLN PRLH 0 0 322 321 1 1
MLN DNAH11 0 0 398 398 1 1
MLN NPFFR1 0 0 174 225 1 1
MLN CCDC174 0 0 175 175 1 1
MLN INS 0 0 601 612 1 2
MLN GLP1R 0 0 96 168 1 1
MLN GHRL 0 500 842 921 1 1
MLN NPW 0 0 219 331 1 1
MLN TRH 0 500 298 633 1 1
MLN LIPN 0 0 291 290 1 1
MLN GPR17 0 0 104 165 1 1
MLN PYY 0 0 736 742 1 1
MLN NTSR1 0 0 126 180 1 1
MLN EDN3 0 500 89 525 1 1
MLN NMS 0 300 81 329 1 1
MLN SFTPB 0 0 0 300 1 1
MLN AQP3 0 0 235 235 1 1
MLN KCNH2 0 0 247 246 1 1
MLN ALX3 0 0 0 155 1 1
MLN CALCB 0 0 150 187 1 1
MLN SST 0 0 844 850 1 1
MLN GNRH1 0 500 181 572 1 1
MLN ADM 0 0 242 241 1 2
MLN GRP 0 500 684 835 1 2
MLN GPR39 0 0 720 722 1 1
MLN COPA 0 0 250 250 1 1
MLN PMCH 0 300 0 300 1 1
MLN EDNRA 0 0 76 640 1 1
MLN PROK2 0 500 62 510 1 1
MLN NPFF 0 300 220 529 1 1
MLN QRFP 0 300 216 453 1 1
MLN CYP3A4 0 0 213 235 1 1
MLN CCL23 0 500 0 499 1 1
MLN IAPP 0 0 270 270 1 2
MLN GABRB1 0 0 0 155 1 1
MLN TAC1 0 300 733 805 1 1
MLN AQP8 0 0 227 226 1 1
MLN AVP 0 300 61 453 1 1
MLN IL6 0 0 151 150 1 2
MLN HTR5A 0 0 72 150 1 1
MLN GPR37 0 0 181 619 1 1
MLN NMBR 0 0 146 514 1 1
MLN PIRT 0 0 0 154 1 1
MLN BCHE 0 0 208 208 1 1
MLN DPP4 0 0 154 153 1 1
MLN SAA1 0 500 0 499 1 1
MLN SCG2 0 0 194 218 1 1
MLN OXT 0 300 292 490 1 1
MLN NMU 0 300 458 732 1 1
MLN AGRP 0 0 167 167 1 1
MLN CCL28 0 0 208 208 1 1
MLN F2 0 500 83 521 1 1
MLN OSTN 0 0 134 225 1 1
MLN SCT 0 0 865 865 1 1
MLN KIT 0 0 185 185 1 2
MLN LEP 0 0 325 325 1 1
MLN TRPV1 0 0 253 252 1 2
MLN RSPH9 0 0 487 487 1 1
MLN DNAI2 0 0 432 432 1 1
MLN APP 0 500 0 499 1 2
MLN FNDC3A 0 0 124 160 1 1
MLN TUBB2A 0 0 603 603 1 1
MLN C6orf141 0 0 252 382 1 1
MLN ENHO 0 0 135 271 1 1
MLN GPR148 0 0 228 227 1 1
MLN ALB 0 0 168 167 1 2
MLN NME8 0 0 410 410 1 1
MLN KNG1 0 300 298 487 1 1
MLN UCN2 0 0 90 182 1 1
MLN EDN1 0 500 123 542 1 1
MLN DNAAF2 0 0 489 489 1 1
MLN PPY 0 0 861 861 1 1
MLN INSL5 0 0 265 266 1 1
MLN ACHE 0 0 391 390 1 2
MLN PROK1 0 500 0 499 1 1
MLN VIP 0 0 758 758 1 1
MLN CRH 0 0 298 298 1 1
MLN DNAI1 0 0 500 499 1 1
MLN SPX 0 0 70 180 1 1
MLN ATP4A 0 0 419 431 1 1
MLN HTR3A 0 0 122 183 1 1
MLN PRL 0 0 264 264 1 1
MLN OXGR1 0 0 120 168 1 1
MLN UCN 0 0 179 179 1 1
MLN KISS1 0 300 92 337 1 1
MLN ADCYAP1 0 0 193 193 1 1
MLN POMC 0 0 466 465 1 1
MLN GNRH2 0 500 57 508 1 1
MLN TUBB 0 0 603 603 1 1
MLN KITLG 0 0 185 185 1 1
MLN DNAH5 0 0 416 416 1 1
MLN BCAS4 0 0 151 344 1 1
MLN ENO2 0 0 174 173 1 1
MLN C1orf127 0 0 216 341 1 1
MLN RGS4 0 0 150 248 1 1
MLN NMUR1 0 0 107 228 1 1
MLN CALCA 0 0 565 565 1 1
MLN PSAP 0 0 57 647 1 1
MLN DNAAF1 0 0 432 432 1 1
MLN NPS 0 300 113 352 1 1
MLN GAL 0 0 469 469 1 1
MLN HTR4 0 0 370 466 1 1
MLN CCK 0 300 844 889 1 1
MLN HLA-DQA2 0 0 270 270 1 1
MLN GAST 0 300 876 909 1 1
MLN DLEU7 0 0 0 183 1 1
MLN CORT 0 0 150 208 1 1
MLN APOA4 0 0 109 345 1 1
MLN HRH2 0 0 235 235 1 1
MLN TTC19 244 0 0 243 1 1
MLN DLD 0 0 212 212 1 2
MLN TAAR2 0 0 82 166 1 1
MLN MBOAT4 0 0 340 373 1 1
MLN XCL1 0 500 0 499 1 1
MLN VR1 0 0 253 252 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005179 Molecular Function hormone activity enables IEA
GO:0031788 Molecular Function motilin receptor binding enables IBA
GO:0031788 Molecular Function motilin receptor binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0007165 Biological Process signal transduction involved_in IEA
GO:0005576 Cellular Component extracellular region located_in TAS
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Signaling by GPCR Reactome R-HSA-372790
Class A/1 (Rhodopsin-like receptors) Reactome R-HSA-373076
Peptide ligand-binding receptors Reactome R-HSA-375276
GPCR downstream signalling Reactome R-HSA-388396
G alpha (q) signalling events Reactome R-HSA-416476
GPCR ligand binding Reactome R-HSA-500792
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001184698 2 mRNA transcript variant 3 NC_000006 Reference
NM_001040109 2 mRNA transcript variant 2 NC_000006 Reference
NM_002418 3 mRNA transcript variant 1 NC_000006 Reference