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MST1

macrophage stimulating 1
General Information
Name macrophage stimulating 1
Alias
  • hepatocyte growth factor-like protein
  • hepatocyte growth factor-like protein homolog
  • macrophage stimulating 1 (hepatocyte growth factor-like)
  • macrophage-stimulating protein
Gene_family
organism Homo sapiens
entrez_id 4485
location 3p21.31
transcript_count 13
exon_count 18
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
    Stringdb Hepatocyte growth factor-like protein; Macrophage stimulating 1
    nextProt None
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MST1 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
MST1 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
MST1 BioGRID HSPA5 GeneID BioGRID Affinity Capture-MS
MST1 BioGRID LDLR GeneID BioGRID Negative Genetic
MST1 BioGRID PPM1F GeneID BioGRID Affinity Capture-Western
MST1 BioGRID RNF123 GeneID BioGRID Affinity Capture-MS
MST1 BioGRID TNNT2 GeneID BioGRID Biochemical Activity
MST1 BioGRID TNNI3 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Two-hybrid
MST1 BioGRID TNNC1 GeneID BioGRID Biochemical Activity
MST1 BioGRID RASSF1 GeneID BioGRID Two-hybrid
MST1 BioGRID FOXO1 GeneID BioGRID Biochemical Activity
MST1 Protein MOB1A GeneID HPRD
MST1 Protein MST1R GeneID HPRD
MST1 Protein KLKB1 GeneID HPRD
MST1 Protein SERPINA3 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
MST1 RASSF5 0 0 204 342 1 1
MST1 CTAGE6 0 0 164 182 1 1
MST1 TRRAP 0 0 0 197 1 1
MST1 SPINT2 0 900 161 914 1 1
MST1 ASIC3 0 0 0 153 1 1
MST1 CYP2D6 0 0 0 170 1 1
MST1 SCGB1C2 0 0 155 154 1 1
MST1 FGA 0 0 0 177 1 1
MST1 NRG1 0 0 91 253 1 2
MST1 APOC2 0 0 65 242 1 1
MST1 AMT 0 0 0 153 1 1
MST1 RASSF1 192 0 71 277 1 1
MST1 A1BG 0 0 90 165 1 1
MST1 TCL1A 0 0 0 171 1 1
MST1 TGM4 0 0 442 442 1 1
MST1 A2M 0 0 123 186 1 1
MST1 HNF4A 0 0 156 217 1 1
MST1 FOXO3 0 900 150 913 1 2
MST1 YWHAB 0 900 0 901 1 1
MST1 IGFALS 0 0 142 217 1 1
MST1 SLK 0 0 0 354 1 1
MST1 F2 0 0 232 226 1 1
MST1 SRC 0 0 299 317 1 2
MST1 STC2 0 0 0 186 1 1
MST1 NMT2 0 0 104 196 1 1
MST1 HAO1 0 0 0 183 1 1
MST1 LEAP2 0 0 0 151 1 1
MST1 SHBG 0 0 113 160 1 1
MST1 ARG2 0 0 210 228 1 1
MST1 ERBB2 0 0 165 165 1 2
MST1 NGF 0 0 107 162 1 2
MST1 UBA7 0 0 170 323 1 1
MST1 APOA2 0 0 89 168 1 1
MST1 CLEC3B 0 0 252 252 1 1
MST1 GPT 0 0 81 205 1 1
MST1 SEPP1 0 0 122 202 1 1
MST1 FGG 0 0 52 185 1 1
MST1 CST6 0 0 140 165 1 1
MST1 LPA 0 0 112 174 1 1
MST1 KLKB1 213 0 112 264 1 1
MST1 AXL 0 0 167 167 1 2
MST1 SLC26A6 0 0 0 152 1 1
MST1 SDF2 0 0 108 170 1 1
MST1 TMPRSS11D 270 0 322 346 1 1
MST1 DCTN5 0 0 46 254 1 1
MST1 TEAD2 0 0 171 185 1 1
MST1 CSF2 0 0 164 163 1 1
MST1 AKT1 0 900 370 938 1 2
MST1 CCL16 0 0 166 165 1 1
MST1 FNIP2 0 0 0 190 1 1
MST1 CDK3 0 0 0 153 1 1
MST1 SEMA4D 0 0 175 175 1 1
MST1 TNF 0 0 202 202 1 2
MST1 HIPK3 0 0 0 189 1 1
MST1 LSM8 0 0 113 205 1 1
MST1 USP19 0 0 92 158 1 1
MST1 PFKFB4 0 0 0 156 1 1
MST1 KNSTRN 0 0 112 313 1 1
MST1 MOB1B 270 0 229 543 1 1
MST1 VGLL4 0 0 97 253 1 1
MST1 IGF1 0 0 194 212 1 2
MST1 SLC3A1 0 0 0 307 1 1
MST1 C8G 0 0 0 197 1 1
MST1 TNNT2 270 0 0 270 1 1
MST1 PLXNB2 0 0 230 258 1 1
MST1 APOC3 0 0 81 215 1 1
MST1 SERPINA10 0 0 134 160 1 1
MST1 SLC38A6 0 0 0 237 1 1
MST1 AGT 0 0 150 266 1 1
MST1 SRSF2 0 0 134 152 1 1
MST1 FOXK2 0 0 0 261 1 1
MST1 ENSG00000196136 0 0 108 150 1 1
MST1 NAT9 0 0 261 642 1 1
MST1 GCM2 0 0 61 216 1 1
MST1 C8A 0 0 0 237 1 1
MST1 SERPINE2 0 0 57 382 1 1
MST1 ATP2B2 0 0 73 233 1 1
MST1 WDR6 0 0 162 182 1 1
MST1 PROZ 0 0 292 217 1 1
MST1 CCND1 0 0 164 186 1 2
MST1 APEH 0 0 827 830 1 1
MST1 SERPINE1 0 0 93 434 1 1
MST1 CDK1 0 0 81 161 1 2
MST1 YWHAQ 0 900 45 900 1 1
MST1 CBL 0 0 195 195 1 1
MST1 SERPINE3 0 0 208 481 1 1
MST1 HMSD 0 0 60 166 1 1
MST1 NTRK1 0 0 549 549 1 1
MST1 PLA2G12B 0 0 0 191 1 1
MST1 SAV1 0 0 325 478 1 1
MST1 SEMA4G 0 0 137 188 1 1
MST1 CYP4F22 0 0 93 206 1 1
MST1 TACSTD2 0 0 86 153 1 1
MST1 PLXNC1 0 0 227 226 1 1
MST1 FGB 0 0 0 175 1 1
MST1 SKAP1 0 0 212 354 1 1
MST1 FERMT3 0 0 113 176 1 1
MST1 DOCK8 0 0 173 173 1 1
MST1 PAX1 0 0 0 250 1 1
MST1 PTH2R 0 0 60 236 1 1
MST1 PTH1R 0 0 0 176 1 1
MST1 VEGFA 0 0 240 267 1 2
MST1 GC 0 0 73 152 1 1
MST1 GLIPR1 0 0 73 384 1 1
MST1 SERPINF2 0 0 82 333 1 1
MST1 SLC7A7 0 0 0 294 1 1
MST1 ADAMTS13 0 0 57 184 1 1
MST1 NOSTRIN 0 0 96 171 1 1
MST1 TF 0 0 117 220 1 2
MST1 SKAP2 0 0 91 239 1 1
MST1 IL10 0 0 166 165 1 2
MST1 ITGB4 0 0 123 160 1 1
MST1 PLXNB3 0 0 228 250 1 1
MST1 TNFRSF10C 0 0 189 189 1 1
MST1 TYRO3 0 0 112 173 1 1
MST1 SERPINC1 0 0 91 266 1 1
MST1 SHC1 0 0 166 165 1 1
MST1 SMAD5 0 0 66 164 1 1
MST1 FRYL 0 0 118 205 1 1
MST1 TEAD1 0 0 261 277 1 1
MST1 LCAT 0 0 134 187 1 1
MST1 CCL28 0 0 181 181 1 1
MST1 MAPKAPK3 0 0 94 150 1 1
MST1 LATS1 0 0 392 501 1 1
MST1 HABP2 0 0 167 269 1 1
MST1 FN1 0 0 203 287 1 2
MST1 FNIP1 0 0 0 286 1 1
MST1 CASR 0 0 45 251 1 2
MST1 TBP 0 0 0 258 1 1
MST1 VTN 0 0 182 264 1 1
MST1 LPAR2 0 0 52 263 1 1
MST1 C3 0 0 180 215 1 2
MST1 HS1BP3 0 0 0 169 1 2
MST1 MST1R 974 900 988 999 1 1
MST1 ATP2B1 0 0 0 189 1 1
MST1 TEAD4 0 0 184 198 1 1
MST1 HPN 0 900 541 920 1 1
MST1 PLXNB1 0 0 251 278 1 1
MST1 HIPK2 0 0 67 234 1 2
MST1 YAP1 0 0 261 377 1 2
MST1 F9 0 0 207 171 1 1
MST1 SEMA6C 0 0 137 168 1 1
MST1 MURC 0 0 96 293 1 1
MST1 ITGAM 0 900 133 909 1 1
MST1 MET 0 0 600 608 1 2
MST1 PLXNA4 0 0 211 211 1 1
MST1 PPM1A 0 0 0 218 1 1
MST1 ERF 0 0 69 220 1 1
MST1 BECN1 270 0 70 302 1 2
MST1 ZMYND11 0 0 0 307 1 1
MST1 SPINT1 0 900 392 938 1 1
MST1 PFKFB1 0 0 0 156 1 1
MST1 RAB11B 0 0 218 218 1 1
MST1 YWHAZ 0 900 0 900 1 1
MST1 FOXO1 270 0 136 384 1 2
MST1 ITGB2 0 900 53 903 1 1
MST1 RP2 0 0 162 161 1 1
MST1 PTH 0 0 73 157 1 1
MST1 FOXK1 0 0 0 190 1 1
MST1 GDPD2 0 0 54 152 1 1
MST1 HPX 0 0 184 274 1 1
MST1 SFN 0 900 0 900 1 2
MST1 ST14 270 0 602 454 1 1
MST1 PLXND1 0 0 211 230 1 1
MST1 FAT4 0 0 100 164 1 1
MST1 TRPV5 0 0 53 267 1 1
MST1 YWHAH 0 900 0 900 1 1
MST1 AHSG 0 0 94 173 1 1
MST1 SCRIB 270 0 0 382 1 1
MST1 CSF1 0 0 124 168 1 1
MST1 NOD2 0 0 122 185 1 2
MST1 AFP 0 0 107 159 1 2
MST1 APCS 0 0 103 164 1 1
MST1 GMPPB 0 0 123 183 1 1
MST1 CPSF4 0 0 107 196 1 1
MST1 MED26 0 0 0 216 1 1
MST1 LMNTD2 0 0 0 156 1 1
MST1 NRSN1 0 0 127 181 1 1
MST1 CXCL5 0 0 184 183 1 1
MST1 SLC7A6 0 0 0 294 1 1
MST1 AFM 0 0 150 220 1 1
MST1 REN 0 0 0 155 1 1
MST1 RHBG 0 0 95 217 1 1
MST1 CDK2 0 0 73 170 1 2
MST1 CDCP1 0 0 234 315 1 1
MST1 HRAS 0 0 122 203 1 2
MST1 CTNNB1 0 0 263 263 1 2
MST1 LATS2 0 0 172 322 1 1
MST1 ENSG00000224916 0 0 0 222 1 1
MST1 HIF1A 0 0 159 177 1 2
MST1 IL1B 0 0 160 159 1 2
MST1 F11 0 0 114 171 1 1
MST1 HGFAC 0 0 506 301 1 1
MST1 IL6 0 0 232 231 1 2
MST1 SCAF11 0 0 194 194 1 1
MST1 TRPV6 0 0 0 258 1 1
MST1 C4A 0 0 83 203 1 1
MST1 CYR61 0 0 85 222 1 1
MST1 MARK4 0 0 67 204 1 1
MST1 NOTCH1 0 0 113 158 1 2
MST1 SCNN1D 0 0 0 155 1 1
MST1 SERPINI1 0 0 62 363 1 1
MST1 EPO 0 0 151 171 1 2
MST1 PLEC 0 0 218 246 1 1
MST1 FAM212A 0 0 218 218 1 1
MST1 SPSB2 0 0 171 171 1 1
MST1 KHDRBS1 0 0 190 190 1 1
MST1 PFKFB3 0 0 0 290 1 2
MST1 CREBBP 0 0 57 265 1 1
MST1 APOA1 0 0 95 238 1 1
MST1 MAP2K7 0 0 142 170 1 1
MST1 PLGLB2 0 0 128 268 1 1
MST1 SMAD2 0 0 127 175 1 2
MST1 GAPDH 0 0 155 154 1 2
MST1 SPRYD4 0 0 231 333 1 1
MST1 RBM23 0 0 246 245 1 1
MST1 SERPINA5 0 0 150 195 1 1
MST1 WWTR1 0 0 234 234 1 1
MST1 YY1AP1 0 0 257 274 1 1
MST1 RUVBL2 0 0 0 205 1 1
MST1 SEMA6A 0 0 260 260 1 1
MST1 APOH 0 0 57 153 1 1
MST1 IGF1R 0 0 213 213 1 2
MST1 MYC 0 0 142 234 1 2
MST1 ETHE1 0 0 0 205 1 1
MST1 NR0B2 0 0 113 156 1 1
MST1 STK11 270 0 62 347 1 2
MST1 PLXNA2 0 0 212 212 1 1
MST1 C5 0 0 113 155 1 1
MST1 VGLL3 0 0 0 189 1 1
MST1 ARMC10 0 0 181 181 1 1
MST1 CYB561 0 0 134 267 1 1
MST1 TCL1B 0 0 43 304 1 1
MST1 STC1 0 0 90 383 1 1
MST1 MKNK2 0 0 181 201 1 1
MST1 APBB1IP 0 0 422 422 1 1
MST1 GIG25 213 0 108 287 1 1
MST1 SFT2D1 234 0 0 234 1 1
MST1 CPB2 0 0 0 179 1 1
MST1 RBL1 0 0 0 258 1 1
MST1 SLC2A1 0 0 0 156 1 2
MST1 EGFR 0 0 321 340 1 2
MST1 TP53 0 0 170 221 1 2
MST1 MDM2 0 0 81 175 1 2
MST1 MARK1 270 0 0 289 1 1
MST1 SEMA3B 0 0 305 331 1 1
MST1 HNRNPH2 0 0 159 158 1 1
MST1 STAT3 0 0 202 202 1 2
MST1 NF2 0 0 155 161 1 1
MST1 SRSF1 0 0 603 603 1 1
MST1 MED23 0 0 0 188 1 1
MST1 TNNC1 270 0 0 270 1 1
MST1 CTBP2 0 0 0 531 1 1
MST1 ATP2B4 0 0 0 189 1 1
MST1 TPR 0 0 122 165 1 1
MST1 AMBP 0 0 57 225 1 1
MST1 RNF123 270 0 76 587 1 1
MST1 VGLL2 0 0 0 215 1 1
MST1 EP300 0 0 44 255 1 2
MST1 F7 0 0 134 177 1 1
MST1 KAT2A 0 0 0 250 1 1
MST1 STK10 0 0 0 188 1 1
MST1 FAP 0 0 0 189 1 2
MST1 DCAF7 0 0 0 239 1 1
MST1 ALB 0 0 184 256 1 2
MST1 CCL2 0 0 167 167 1 2
MST1 KNG1 0 0 103 192 1 1
MST1 SLC38A4 0 0 0 177 1 1
MST1 FETUB 0 0 88 198 1 1
MST1 TEAD3 0 0 216 233 1 1
MST1 SLC3A2 0 0 0 193 1 1
MST1 C8B 0 0 0 179 1 1
MST1 PLG 0 0 468 204 1 1
MST1 CDH1 0 0 204 204 1 2
MST1 SLC26A1 0 0 0 189 1 1
MST1 SCGB1C1 0 0 160 159 1 1
MST1 YWHAG 0 900 0 900 1 1
MST1 C4B 0 0 103 183 1 1
MST1 CP 0 0 124 181 1 1
MST1 SERPING1 0 0 135 167 1 1
MST1 SLC26A3 0 0 0 217 1 1
MST1 PTK2 0 0 162 161 1 2
MST1 XRCC1 0 0 57 160 1 1
MST1 MAPK8 0 0 95 151 1 2
MST1 ARG1 0 0 243 261 1 2
MST1 MOB1A 213 0 210 495 1 1
MST1 RPTOR 0 0 0 188 1 2
MST1 NEK9 0 0 0 252 1 1
MST1 SLC8A3 0 0 0 201 1 1
MST1 PHLDB3 0 0 74 219 1 1
MST1 C9 0 0 122 234 1 1
MST1 RPL22L1 0 0 123 197 1 1
MST1 PLAUR 0 0 215 215 1 1
MST1 EGF 0 0 261 262 1 2
MST1 PROC 0 0 222 205 1 1
MST1 OIT3 0 0 150 171 1 1
MST1 SESN3 0 0 46 179 1 1
MST1 PLGLB1 0 0 124 265 1 1
MST1 VPREB3 0 0 0 213 1 1
MST1 SLC8A1 0 0 0 201 1 1
MST1 ITIH3 0 0 0 185 1 1
MST1 TMPRSS6 0 0 122 214 1 1
MST1 JUN 0 0 210 210 1 2
MST1 ASIC4 0 0 0 186 1 1
MST1 ITGAL 0 0 244 244 1 1
MST1 TAZ 0 0 299 539 1 1
MST1 ITIH2 0 0 75 291 1 1
MST1 SLC8A2 0 0 0 201 1 1
MST1 ATP2B3 0 0 0 207 1 1
MST1 GRB2 0 0 244 243 1 1
MST1 IGFBP4 0 0 123 162 1 1
MST1 SERPIND1 0 0 138 239 1 1
MST1 YWHAE 0 900 52 901 1 1
MST1 PPM1F 270 0 0 271 1 1
MST1 ORM2 0 0 134 187 1 1
MST1 NEK5 0 0 140 335 1 1
MST1 MOB2 0 0 0 159 1 1
MST1 SMAD1 0 0 66 258 1 2
MST1 CXCL12 0 0 187 187 1 2
MST1 PLXNA1 0 0 211 211 1 1
MST1 AGA 0 0 155 154 1 1
MST1 PI16 0 0 113 203 1 1
MST1 TNNI3 270 0 0 321 1 1
MST1 SLC15A1 0 0 0 210 1 1
MST1 RHOA 0 0 125 158 1 2
MST1 PLXNA3 0 0 218 218 1 1
MST1 ICAM1 0 900 112 907 1 2
MST1 SEMA4B 0 0 136 157 1 1
MST1 STK4 0 0 324 353 1 1
MST1 TP73 0 0 0 261 1 2
MST1 SETD1A 0 0 0 162 1 1
MST1 SLC9A3 0 0 0 160 1 1
MST1 CTBP1 0 0 0 303 1 1
MST1 ARID4B 0 0 153 165 1 1
MST1 PDGFD 0 0 260 323 1 1
MST1 F12 0 0 315 250 1 1
MST1 SIRT3 0 0 81 194 1 2
MST1 MAPK3 0 0 244 243 1 2
MST1 MMP9 0 0 134 160 1 2
MST1 FTCD 0 0 0 196 1 1
MST1 UHRF1BP1 0 0 108 169 1 1
MST1 ACTB 0 0 151 150 1 2
MST1 INS 0 0 146 172 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004175 Molecular Function endopeptidase activity NOT enables IBA
GO:0005515 Molecular Function protein binding enables IPI
GO:0030971 Molecular Function receptor tyrosine kinase binding enables IBA
GO:0030971 Molecular Function receptor tyrosine kinase binding enables IDA
GO:0045721 Biological Process negative regulation of gluconeogenesis involved_in IDA
GO:0006508 Biological Process proteolysis involved_in IEA
GO:2000479 Biological Process regulation of cAMP-dependent protein kinase activity involved_in IDA
GO:0046425 Biological Process regulation of receptor signaling pathway via JAK-STAT involved_in IBA
GO:0062023 Cellular Component collagen-containing extracellular matrix located_in HDA
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IBA
GO:0005615 Cellular Component extracellular space located_in IDA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Signaling by MST1 Reactome R-HSA-8852405
Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
Hippo signaling regulation pathways (WP4540) WikiPathways WP4540_r120395
Hippo-Yap signaling pathway (WP4537) WikiPathways WP4537_r103300
Leukocyte-intrinsic Hippo pathway functions (WP4542) WikiPathways WP4542_r120673
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms (WP4534) WikiPathways WP4534_r103303
Hippo-Merlin signaling dysregulation (WP4541) WikiPathways WP4541_r116745
Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_146060 2 miscRNA transcript variant 2 NC_000003 Reference
XM_047448159 1 mRNA transcript variant X3 NC_000003 Reference
NM_001393584 1 mRNA transcript variant 6 NC_000003 Reference
XM_017006460 3 mRNA transcript variant X1 NC_000003 Reference
NM_001393581 1 mRNA transcript variant 3 NC_000003 Reference
NM_001393583 1 mRNA transcript variant 5 NC_000003 Reference
NM_001393585 1 mRNA transcript variant 7 NC_000003 Reference
XM_047448158 1 mRNA transcript variant X2 NC_000003 Reference
NM_001393582 1 mRNA transcript variant 4 NC_000003 Reference
NM_020998 4 mRNA transcript variant 1 NC_000003 Reference
XM_047448160 1 mRNA transcript variant X4 NC_000003 Reference
XM_011533738 4 mRNA transcript variant X5 NC_000003 Reference
XM_047448161 1 mRNA transcript variant X6 NC_000003 Reference