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MTM1

myotubularin 1
General Information
Name myotubularin 1
Alias
  • myotubularin
  • phosphatidylinositol-3,5-bisphosphate 3-phosphatase
  • phosphatidylinositol-3-phosphate phosphatase
Gene_family Phosphoinositide phosphatases|Myotubularins
organism Homo sapiens
entrez_id 4534
location Xq28
transcript_count 15
exon_count 19
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]
    Stringdb Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not f [...]
    nextProt Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MTM1 BioGRID MTMR9 GeneID BioGRID Negative Genetic
MTM1 BioGRID MTMR2 GeneID BioGRID Negative Genetic
MTM1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PMPCA GeneID BioGRID Co-fractionation
MTM1 BioGRID SNX27 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID POTEF GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID TRIML2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SNX17 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID TUBA3C GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PTPN9 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CGA GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID KRT5 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID KRT2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID HLA-C GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID RELCH GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID TMX3 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID STOML2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID MTMR11 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID HAX1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SNX2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PSMD11 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PSMD7 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PSMD1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PFAS GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PCM1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID HSPD1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID ZNF548 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CHCHD3 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID UBR5 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID OSBPL3 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID HECTD1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID GANAB GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CCT5 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID IMMT GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID STIP1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CCT7 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID HELZ GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SEC16A GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PPFIA1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID VCP GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SCO1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID RCN1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID PTPRH GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CSK GeneID BioGRID Synthetic Lethality
MTM1 BioGRID KRAS GeneID BioGRID Proximity Label-MS
MTM1 BioGRID CCT8L1P GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SNX6 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID MTMR10 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SAMM50 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SCO2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID MTFR1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CIAO1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID AKR7A2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID VBP1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID TARBP2 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID SOAT1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID OXA1L GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID NDUFA9 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID MTM1 GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID ILK GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CALU GeneID BioGRID Affinity Capture-MS
MTM1 BioGRID CUL4A GeneID BioGRID Co-fractionation
MTM1 BioGRID BIN1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
MTM1 BioGRID KMT2A GeneID BioGRID Reconstituted Complex
MTM1 BioGRID KBTBD7 GeneID BioGRID Affinity Capture-MS
MTM1 Protein MTMR12 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
MTM1 ACTA1 0 0 391 392 1 1
MTM1 STXBP6 0 0 0 153 1 1
MTM1 VPS39 0 0 144 250 1 1
MTM1 TEX28 0 0 216 216 1 1
MTM1 CPN1 0 0 96 194 1 1
MTM1 PTPMT1 0 0 322 323 1 1
MTM1 DHTKD1 0 0 120 217 1 1
MTM1 DMBT1 0 0 325 325 1 1
MTM1 JPH3 0 0 163 315 1 1
MTM1 CACNA1S 0 0 200 289 1 1
MTM1 SRGAP2 0 0 0 203 1 1
MTM1 ALOX12B 0 0 170 194 1 1
MTM1 OR2F1 0 0 216 216 1 1
MTM1 FLNA 0 0 74 158 1 1
MTM1 TTN 0 0 451 466 1 1
MTM1 BOLA2 0 0 49 169 1 1
MTM1 TNPO3 0 0 103 164 1 1
MTM1 SYNJ1 0 0 292 367 1 1
MTM1 SSR4 0 0 206 206 1 1
MTM1 PIP4K2A 0 650 210 723 1 1
MTM1 SLC29A2 0 0 96 207 1 1
MTM1 SPEG 0 0 786 789 1 1
MTM1 SERINC1 0 0 124 235 1 1
MTM1 MECP2 0 0 185 185 1 1
MTM1 KIAA1549L 0 0 94 237 1 1
MTM1 GDAP1 0 0 122 155 1 1
MTM1 PI3 0 0 397 396 1 2
MTM1 CDC14A 0 0 163 164 1 1
MTM1 BTBD9 0 0 0 168 1 1
MTM1 PLCB3 0 650 0 671 1 1
MTM1 CAPN3 0 0 217 221 1 1
MTM1 MPP3 0 0 52 222 1 1
MTM1 PPIP5K1 0 0 0 187 1 1
MTM1 ST3GAL4 0 0 74 237 1 1
MTM1 CBLB 0 0 0 207 1 1
MTM1 ZNF812 0 0 235 235 1 1
MTM1 TRDN 0 0 222 271 1 1
MTM1 INPP5F 0 650 59 698 1 1
MTM1 PIK3CA 0 0 49 187 1 2
MTM1 PLCB2 0 650 0 671 1 1
MTM1 PIK3R3 0 650 0 657 1 1
MTM1 MYH10 0 0 411 410 1 1
MTM1 PPP1R3C 0 0 81 222 1 1
MTM1 PTPLB 0 0 141 272 1 1
MTM1 APPL1 0 0 228 305 1 1
MTM1 ANKRD42 0 0 170 176 1 1
MTM1 ATP2B4 0 0 0 151 1 1
MTM1 HGS 0 0 216 235 1 2
MTM1 ATP8B4 0 0 0 167 1 1
MTM1 ZDHHC15 0 0 180 186 1 1
MTM1 PTPN4 0 0 141 192 1 1
MTM1 GABRA3 0 0 397 396 1 1
MTM1 MTCH1 0 0 46 306 1 1
MTM1 ERGIC2 0 0 166 172 1 1
MTM1 PLEKHA3 0 0 334 374 1 1
MTM1 MYH6 0 0 195 195 1 1
MTM1 FGD4 0 0 94 190 1 1
MTM1 SERPINH1 0 0 556 556 1 1
MTM1 MCOLN1 0 0 231 262 1 2
MTM1 KRT5 260 0 0 260 1 1
MTM1 INPP5E 0 0 212 248 1 1
MTM1 GLRX5 0 0 275 275 1 1
MTM1 OCRL 0 0 469 526 1 1
MTM1 TCEAL2 0 0 184 183 1 1
MTM1 ATP2C1 0 0 0 243 1 1
MTM1 LAMP1 0 0 125 175 1 2
MTM1 HTR1E 0 0 0 207 1 1
MTM1 RAB2A 0 0 150 226 1 1
MTM1 SGCG 0 0 182 203 1 1
MTM1 MYH14 0 0 432 432 1 1
MTM1 TNNT3 0 0 75 176 1 1
MTM1 KRT2 260 0 87 295 1 1
MTM1 ORAI1 0 0 95 151 1 1
MTM1 FHOD1 0 0 94 250 1 1
MTM1 BRSK1 0 0 0 245 1 1
MTM1 MYOT 0 0 267 267 1 1
MTM1 LMNA 0 0 126 177 1 2
MTM1 IRAK1 0 0 0 156 1 1
MTM1 MTMR3 0 0 812 168 1 2
MTM1 GNE 0 0 244 244 1 1
MTM1 MTOR 0 0 86 202 1 2
MTM1 PTPN13 0 0 169 187 1 1
MTM1 MOSPD1 0 0 195 218 1 1
MTM1 PLEK 0 0 391 390 1 1
MTM1 DYNC1LI2 0 0 129 248 1 1
MTM1 MTMR7 0 0 812 258 1 1
MTM1 JPH4 0 0 181 232 1 1
MTM1 PIK3C3 0 650 765 944 1 2
MTM1 SMN1 0 0 142 181 1 1
MTM1 AFF2 0 0 229 228 1 1
MTM1 HSFX1 0 0 212 229 1 1
MTM1 DOCK1 0 0 397 451 1 1
MTM1 MTMR6 0 0 810 250 1 1
MTM1 DOK7 0 0 401 400 1 1
MTM1 RAB5A 0 0 460 519 1 2
MTM1 CLINT1 0 0 213 213 1 1
MTM1 SGCD 0 0 180 197 1 1
MTM1 NEDD4 0 0 90 165 1 2
MTM1 BAG3 0 0 139 283 1 2
MTM1 POMT1 0 0 218 231 1 1
MTM1 SRGAP2C 0 0 0 203 1 1
MTM1 INPP5B 0 0 323 395 1 1
MTM1 DNM3 0 0 141 297 1 1
MTM1 POMGNT2 0 0 134 267 1 1
MTM1 KLHL9 0 0 244 301 1 1
MTM1 SLX4IP 0 0 167 682 1 1
MTM1 DCAF6 0 0 0 196 1 1
MTM1 AKR1C3 0 0 283 282 1 1
MTM1 FYCO1 0 0 107 162 1 2
MTM1 CLCN2 0 0 0 196 1 1
MTM1 CNOT1 0 0 66 178 1 1
MTM1 ELMO3 0 0 395 721 1 1
MTM1 ARHGAP4 0 0 117 170 1 1
MTM1 PTPLA 0 0 731 731 1 1
MTM1 PIK3R4 0 0 705 718 1 2
MTM1 ATP8A2 0 0 0 231 1 1
MTM1 ABL1 0 0 150 391 1 1
MTM1 ARL5B 0 0 97 229 1 1
MTM1 BRSK2 0 0 0 336 1 1
MTM1 SMG1 0 0 0 162 1 1
MTM1 DUSP5 0 0 150 151 1 1
MTM1 GAPDH 0 0 141 166 1 2
MTM1 ATG14 0 0 170 202 1 2
MTM1 MYPN 0 0 123 475 1 1
MTM1 KSR2 0 0 0 156 1 1
MTM1 MYH3 0 0 396 406 1 1
MTM1 LMOD3 0 0 270 301 1 1
MTM1 PLCG2 0 650 0 663 1 1
MTM1 ZNF41 0 0 178 198 1 1
MTM1 AMER1 0 0 74 456 1 1
MTM1 ZSCAN18 0 0 160 159 1 1
MTM1 PNPO 0 0 107 199 1 1
MTM1 FIG4 0 900 518 967 1 1
MTM1 ATP1A3 0 0 74 205 1 1
MTM1 RYR2 0 0 116 194 1 1
MTM1 PLEC 0 0 171 202 1 1
MTM1 DPAGT1 0 0 300 346 1 1
MTM1 MINPP1 0 0 261 261 1 1
MTM1 FBXO32 0 0 95 206 1 2
MTM1 IBA57 0 0 193 194 1 1
MTM1 SH3GLB2 0 0 158 157 1 1
MTM1 FLNC 0 0 211 232 1 1
MTM1 DYNC1LI1 0 0 107 213 1 1
MTM1 WASL 0 0 141 181 1 1
MTM1 INPPL1 0 0 244 277 1 1
MTM1 PNCK 0 0 156 179 1 1
MTM1 AGRN 0 0 115 170 1 1
MTM1 NEK3 0 0 0 153 1 1
MTM1 CRK 0 0 95 155 1 1
MTM1 MCOLN2 0 0 128 162 1 1
MTM1 CFL2 0 0 336 336 1 1
MTM1 CSRP2 0 0 101 260 1 1
MTM1 ERC2 0 0 0 271 1 1
MTM1 SRGAP2B 0 0 0 203 1 1
MTM1 SOD1 0 0 112 309 1 2
MTM1 MED12 0 0 67 227 1 1
MTM1 VCP 76 0 77 265 1 2
MTM1 YWHAE 0 0 0 198 1 1
MTM1 FST 0 0 70 213 1 1
MTM1 WDFY2 0 0 129 151 1 1
MTM1 ATP2B3 0 0 181 275 1 1
MTM1 GRN 0 0 95 342 1 1
MTM1 ABI1 0 0 161 305 1 1
MTM1 DAPK1 0 0 49 435 1 2
MTM1 ENOX2 0 0 267 267 1 1
MTM1 PLCG1 0 650 94 682 1 1
MTM1 EFR3A 0 0 54 175 1 1
MTM1 CALB1 0 0 0 190 1 1
MTM1 MYH7B 0 0 398 398 1 1
MTM1 SNX1 0 0 182 216 1 1
MTM1 PLCB4 0 650 74 683 1 1
MTM1 ZNF660 0 0 292 292 1 1
MTM1 PTPN21 0 0 74 150 1 1
MTM1 STXBP5 0 0 0 153 1 1
MTM1 PIK3CG 0 0 71 185 1 1
MTM1 SIX4 0 0 81 178 1 1
MTM1 COLQ 0 0 325 353 1 1
MTM1 PI4K2B 0 650 167 729 1 1
MTM1 CUL4A 272 0 0 387 1 1
MTM1 HSFX2 0 0 212 229 1 1
MTM1 RNGTT 0 0 123 154 1 1
MTM1 PARN 0 0 0 303 1 1
MTM1 TNNT1 0 0 241 297 1 1
MTM1 CHRNB1 0 0 208 208 1 1
MTM1 ENSG00000150076 0 0 180 181 1 1
MTM1 SH3TC2 0 0 99 215 1 1
MTM1 DES 282 0 0 354 1 2
MTM1 KBTBD13 0 0 452 452 1 1
MTM1 PLEKHA1 0 0 212 212 1 1
MTM1 SBF1 0 0 824 442 1 1
MTM1 ZMYM2 0 0 306 344 1 1
MTM1 ATP8B1 0 0 0 167 1 1
MTM1 PROSC 0 0 141 372 1 1
MTM1 MYH9 0 0 323 323 1 1
MTM1 SH3TC1 0 0 0 188 1 1
MTM1 VPS16 0 0 95 170 1 1
MTM1 IGDCC3 0 0 204 236 1 1
MTM1 ADSS 0 0 108 160 1 1
MTM1 RHOG 0 0 57 173 1 1
MTM1 B3GALNT2 0 0 205 254 1 1
MTM1 PHPT1 0 0 115 210 1 1
MTM1 IFT122 0 0 350 349 1 1
MTM1 PGAM2 0 0 108 163 1 1
MTM1 MYL1 0 0 73 189 1 1
MTM1 TMLHE 0 0 194 194 1 1
MTM1 CMTM1 0 0 406 466 1 1
MTM1 ZFYVE20 0 0 167 219 1 1
MTM1 KIAA1468 260 0 0 261 1 1
MTM1 LLGL2 0 0 0 311 1 1
MTM1 EPM2A 0 0 132 221 1 2
MTM1 SH3PXD2A 0 0 0 307 1 1
MTM1 RYR1 0 0 688 732 1 2
MTM1 TTC7B 0 0 150 333 1 1
MTM1 CLCN1 0 0 203 505 1 1
MTM1 NEFL 0 0 305 307 1 1
MTM1 NSDHL 0 0 218 258 1 1
MTM1 MAP3K9 0 0 82 471 1 1
MTM1 CNTNAP1 0 0 90 292 1 1
MTM1 YWHAG 0 0 0 153 1 1
MTM1 ATP8B2 0 0 0 167 1 1
MTM1 ATP2A1 0 0 215 632 1 1
MTM1 ATP10A 0 0 0 167 1 1
MTM1 ACVR2B 0 0 143 183 1 1
MTM1 LBX1 0 0 74 286 1 1
MTM1 DNM2 0 0 740 769 1 1
MTM1 SGCB 0 0 188 228 1 1
MTM1 BOLA2B 0 0 50 170 1 1
MTM1 PLCD4 0 650 0 673 1 1
MTM1 FAM167A 0 0 323 323 1 1
MTM1 LLGL1 0 0 0 374 1 1
MTM1 BCHE 0 0 0 237 1 1
MTM1 MAP3K11 0 0 0 202 1 1
MTM1 NUP62CL 0 0 284 295 1 1
MTM1 PGK1 0 0 138 172 1 2
MTM1 PVALB 0 0 0 384 1 1
MTM1 DCAF7 0 0 219 297 1 1
MTM1 CEP112 0 0 66 209 1 1
MTM1 SLC25A37 0 0 181 202 1 1
MTM1 DAG1 0 0 171 171 1 1
MTM1 MADD 0 0 260 260 1 1
MTM1 NAA10 0 0 154 153 1 1
MTM1 PIP5K1C 0 0 314 335 1 1
MTM1 ELMO1 0 0 310 436 1 1
MTM1 SH3PXD2B 0 0 0 307 1 1
MTM1 TPTE 0 0 241 242 1 1
MTM1 IMPA2 0 900 0 907 1 1
MTM1 RLTPR 0 0 45 210 1 1
MTM1 PTPN3 0 0 103 187 1 1
MTM1 SH3GLB1 0 0 174 173 1 2
MTM1 GULP1 0 0 358 528 1 1
MTM1 SRGAP1 0 0 0 203 1 1
MTM1 ACHE 0 0 249 403 1 2
MTM1 HMGCL 0 0 97 218 1 1
MTM1 KLHL41 0 0 342 368 1 1
MTM1 NEK9 0 0 0 152 1 1
MTM1 CAPS2 0 0 323 339 1 1
MTM1 ATP2C2 0 0 0 243 1 1
MTM1 CLTC 0 0 55 153 1 1
MTM1 PIK3R1 0 650 0 657 1 1
MTM1 ABL2 0 0 0 308 1 1
MTM1 FKBP1A 0 0 124 164 1 2
MTM1 DAPK3 0 0 0 267 1 2
MTM1 TPM2 0 0 363 363 1 1
MTM1 VPS18 0 0 125 216 1 1
MTM1 SSH1 0 0 139 162 1 1
MTM1 ITGA7 0 0 113 214 1 1
MTM1 MAP2K4 0 0 48 150 1 1
MTM1 LDB3 0 0 170 221 1 1
MTM1 CLIC2 0 0 277 292 1 1
MTM1 ABHD14B 0 0 150 181 1 1
MTM1 AMOT 0 0 96 192 1 1
MTM1 PYGM 0 0 173 209 1 1
MTM1 CUL4B 0 0 66 333 1 1
MTM1 RAPSN 0 0 323 327 1 1
MTM1 ISCA2 0 0 212 212 1 1
MTM1 ATP12A 0 0 0 200 1 1
MTM1 PIK3C2G 0 650 167 780 1 1
MTM1 REC114 0 0 156 155 1 1
MTM1 TMEM55A 0 650 203 722 1 1
MTM1 RAB7A 0 0 424 551 1 2
MTM1 BCAP31 0 0 0 206 1 1
MTM1 PROX1 0 0 57 152 1 1
MTM1 KMT2A 270 0 439 578 1 1
MTM1 SCN4A 0 0 340 357 1 1
MTM1 CHRNE 0 0 346 360 1 1
MTM1 CASK 0 0 82 441 1 1
MTM1 UVRAG 0 0 187 278 1 2
MTM1 ITGA3 0 0 0 150 1 2
MTM1 ZNF275 0 0 241 240 1 1
MTM1 FCHO2 0 0 0 164 1 1
MTM1 PLCB1 0 650 89 688 1 1
MTM1 MYF6 0 0 358 358 1 1
MTM1 SACM1L 0 650 335 799 1 1
MTM1 VPS11 0 0 90 201 1 1
MTM1 CHRNA1 0 0 215 215 1 1
MTM1 JPH2 0 0 231 371 1 1
MTM1 TJP2 0 0 0 186 1 1
MTM1 ATP11C 0 0 0 224 1 1
MTM1 MTMR11 155 0 233 317 1 1
MTM1 ABHD5 0 0 81 165 1 1
MTM1 DAAM2 0 0 134 165 1 1
MTM1 PIK3R2 0 650 95 679 1 1
MTM1 ABI2 0 0 0 198 1 1
MTM1 RCAN1 0 0 57 162 1 2
MTM1 WIPI2 0 0 103 200 1 2
MTM1 ATP11B 0 0 0 157 1 1
MTM1 MYO18B 0 0 150 290 1 1
MTM1 FMR1 0 0 150 228 1 1
MTM1 MYH2 0 0 352 351 1 1
MTM1 ATP2A2 0 0 0 384 1 1
MTM1 F8 0 0 398 409 1 1
MTM1 TMEM243 0 0 202 202 1 1
MTM1 PLCE1 0 650 0 674 1 1
MTM1 SMN2 0 0 113 154 1 1
MTM1 PALLD 0 0 0 258 1 1
MTM1 CHRNG 0 0 234 250 1 1
MTM1 FCHO1 0 0 122 302 1 1
MTM1 CDIPT 0 900 90 922 1 1
MTM1 ELMO2 0 0 376 490 1 1
MTM1 COL6A3 0 0 165 165 1 1
MTM1 PDPK1 0 0 95 250 1 2
MTM1 ATP11A 0 0 0 157 1 1
MTM1 NUDT11 0 0 167 167 1 1
MTM1 YWHAQ 0 0 0 189 1 1
MTM1 ECEL1 0 0 225 224 1 1
MTM1 PRKDC 0 0 0 162 1 2
MTM1 ERC1 0 0 0 394 1 1
MTM1 B3GNT1 0 0 167 252 1 1
MTM1 STYXL1 0 0 140 172 1 1
MTM1 PIK3C2B 0 650 505 902 1 1
MTM1 CBL 0 0 0 207 1 1
MTM1 ATP2B2 0 0 0 151 1 1
MTM1 FAM58A 0 0 172 190 1 1
MTM1 EPG5 0 0 170 311 1 2
MTM1 SNX9 0 0 324 400 1 1
MTM1 MEGF10 0 0 212 284 1 1
MTM1 ATR 0 0 0 162 1 2
MTM1 GMCL1 0 0 166 165 1 1
MTM1 PPIP5K2 0 0 0 187 1 1
MTM1 IPPK 0 0 0 189 1 1
MTM1 EEA1 0 0 392 418 1 2
MTM1 ITGA6 0 0 0 150 1 1
MTM1 SLC29A3 0 0 170 198 1 1
MTM1 C19orf33 0 0 211 211 1 1
MTM1 YWHAB 0 0 0 198 1 1
MTM1 RNASEH1 0 0 103 280 1 1
MTM1 CEP162 0 0 0 205 1 1
MTM1 CDC42 0 0 74 193 1 2
MTM1 LPAR1 0 0 0 189 1 1
MTM1 ALAS2 0 0 123 212 1 1
MTM1 SLC25A39 0 0 325 400 1 1
MTM1 PORCN 0 0 76 312 1 1
MTM1 RABGEF1 0 0 162 182 1 1
MTM1 LYPLA2 0 0 127 315 1 1
MTM1 ECH1 0 0 89 228 1 1
MTM1 DTD1 0 0 180 179 1 1
MTM1 TRIML2 233 0 0 242 1 1
MTM1 CCDC7 0 0 180 198 1 1
MTM1 KBTBD7 263 0 0 263 1 1
MTM1 PREPL 0 0 182 181 1 1
MTM1 ING2 0 0 140 163 1 1
MTM1 BIN1 270 0 701 854 1 1
MTM1 ADSSL1 0 0 135 226 1 1
MTM1 RAB11A 0 0 122 251 1 2
MTM1 PTPN7 0 0 81 162 1 1
MTM1 ZNF414 0 0 244 243 1 1
MTM1 CCZ1 0 0 194 272 1 1
MTM1 VAMP7 0 0 122 150 1 2
MTM1 SBF2 0 0 686 400 1 1
MTM1 JPH1 0 0 218 360 1 1
MTM1 PIK3C2A 0 650 294 861 1 1
MTM1 PPM1D 0 0 63 173 1 1
MTM1 TRRAP 0 0 0 163 1 1
MTM1 RAB7B 0 0 425 460 1 1
MTM1 PIP4K2B 0 650 157 708 1 1
MTM1 DUSP13 0 0 129 188 1 1
MTM1 BOLA2-SMG1P6 0 0 0 162 1 1
MTM1 DYSF 0 0 500 598 1 1
MTM1 ATP10D 0 0 0 167 1 1
MTM1 AKT1 0 0 218 243 1 2
MTM1 MTMR14 0 0 767 917 1 2
MTM1 FKRP 0 0 232 261 1 1
MTM1 SYNJ2 0 0 234 297 1 1
MTM1 IMPA1 0 900 134 917 1 1
MTM1 INPP5D 0 0 154 191 1 1
MTM1 FAN1 0 0 232 365 1 1
MTM1 ATP2A3 0 0 0 252 1 1
MTM1 ISCU 0 0 166 186 1 1
MTM1 WDTC1 0 0 0 196 1 1
MTM1 ATP10B 0 0 0 167 1 1
MTM1 VIP 0 0 0 211 1 1
MTM1 SSH2 0 0 140 151 1 1
MTM1 COL6A1 0 0 143 164 1 1
MTM1 MTMR10 83 0 324 300 1 1
MTM1 MTMR4 0 0 811 175 1 1
MTM1 RAB21 0 0 138 379 1 1
MTM1 KIAA1804 0 0 0 202 1 1
MTM1 EHD1 0 0 146 182 1 1
MTM1 TCAP 0 0 261 334 1 1
MTM1 CCK 0 0 0 426 1 1
MTM1 MYH4 0 0 410 410 1 1
MTM1 SYPL2 0 0 194 319 1 1
MTM1 UBQLN1 0 0 0 187 1 1
MTM1 BTBD2 0 0 66 332 1 1
MTM1 PIKFYVE 0 900 608 971 1 2
MTM1 AIFM1 0 0 75 343 1 1
MTM1 TMEM5 0 0 193 251 1 1
MTM1 TPM3 0 0 367 367 1 1
MTM1 IMPAD1 0 900 47 905 1 1
MTM1 FBN1 0 0 50 243 1 1
MTM1 SRGAP3 0 0 0 203 1 1
MTM1 FBF1 0 0 0 199 1 1
MTM1 WDR81 0 0 243 307 1 1
MTM1 EFR3B 0 0 138 379 1 1
MTM1 CCZ1B 0 0 193 271 1 1
MTM1 JMJD6 0 0 103 181 1 1
MTM1 MAMLD1 0 0 814 814 1 1
MTM1 SOD2 0 0 193 193 1 2
MTM1 DNAJC13 0 0 120 228 1 1
MTM1 TPTE2 0 0 260 261 1 1
MTM1 SGCA 0 0 262 304 1 1
MTM1 WDR35 0 0 244 243 1 1
MTM1 MYH13 0 0 413 412 1 1
MTM1 SNX2 128 0 96 212 1 1
MTM1 TBC1D25 0 0 52 150 1 1
MTM1 DNM1 0 0 247 332 1 1
MTM1 POMGNT1 0 0 216 242 1 1
MTM1 MTMR9 0 0 720 259 1 1
MTM1 AGPAT6 0 0 0 154 1 1
MTM1 RAB11B 0 0 0 151 1 1
MTM1 MSTN 0 0 212 311 1 1
MTM1 KATNBL1 0 0 233 252 1 1
MTM1 CCDC78 0 0 517 517 1 1
MTM1 ALG14 0 0 293 293 1 1
MTM1 MON1A 0 0 241 320 1 1
MTM1 YWHAZ 0 0 45 201 1 1
MTM1 BIN3 0 0 0 235 1 1
MTM1 ISCA1 0 0 195 195 1 1
MTM1 WBP2 0 0 0 189 1 1
MTM1 CAV3 0 0 403 534 1 1
MTM1 MYH11 0 0 306 306 1 1
MTM1 ATP1A1 0 0 0 177 1 1
MTM1 PIK3CB 0 0 92 207 1 1
MTM1 VAC14 0 0 493 501 1 1
MTM1 RUFY2 0 0 0 158 1 1
MTM1 POMK 0 0 166 223 1 1
MTM1 MTMR12 270 800 684 899 1 1
MTM1 ARF6 0 0 155 201 1 1
MTM1 DNAJB6 0 0 120 209 1 1
MTM1 POMT2 0 0 210 228 1 1
MTM1 SLC36A3 0 0 165 165 1 1
MTM1 BECN1 0 0 134 169 1 2
MTM1 PTS 0 0 414 414 1 1
MTM1 GDF11 0 0 56 321 1 1
MTM1 COL6A2 0 0 135 155 1 1
MTM1 GDI1 0 0 234 276 1 1
MTM1 SLC25A40 0 0 120 218 1 1
MTM1 QKI 0 0 68 248 1 1
MTM1 CDS1 0 0 56 154 1 1
MTM1 MYH7 0 0 328 328 1 1
MTM1 EIF4B 0 0 0 365 1 1
MTM1 HSPB8 0 0 123 186 1 2
MTM1 AGPAT9 0 0 0 154 1 1
MTM1 ZFYVE21 0 0 203 203 1 1
MTM1 GFPT1 0 0 253 304 1 1
MTM1 PANK3 0 0 45 304 1 1
MTM1 LIX1 0 0 122 183 1 1
MTM1 MRPS21 0 0 0 252 1 1
MTM1 GMPPB 0 0 260 273 1 1
MTM1 MYH8 0 0 398 398 1 1
MTM1 MAP3K10 0 0 0 202 1 1
MTM1 WDR91 0 0 292 320 1 1
MTM1 TRABD 0 0 210 227 1 1
MTM1 CRYAB 0 0 150 170 1 2
MTM1 YWHAH 130 0 0 232 1 1
MTM1 PIK3CD 0 0 81 197 1 1
MTM1 INPP4B 0 900 193 919 1 1
MTM1 PI4KA 0 650 269 767 1 1
MTM1 LAMA2 0 0 285 284 1 1
MTM1 CHRND 0 0 335 391 1 1
MTM1 PLCZ1 0 650 0 650 1 1
MTM1 MFSD1 0 0 180 179 1 1
MTM1 MYH1 0 0 270 270 1 1
MTM1 SST 0 0 0 384 1 1
MTM1 ATP1A2 0 0 0 177 1 1
MTM1 PI4K2A 0 650 213 729 1 1
MTM1 POGLUT1 0 0 113 265 1 1
MTM1 PDZK1IP1 0 0 467 467 1 1
MTM1 TRIM32 0 0 144 188 1 1
MTM1 COL4A3BP 0 0 92 173 1 1
MTM1 AMPH 0 0 556 693 1 1
MTM1 LITAF 0 0 134 204 1 1
MTM1 MARCKS 0 0 134 166 1 1
MTM1 TJP1 0 0 0 394 1 1
MTM1 DMD 0 0 310 334 1 2
MTM1 ATP8B3 0 0 0 202 1 1
MTM1 SNX17 311 0 0 318 1 1
MTM1 EXOC4 270 0 0 316 1 1
MTM1 SLC25A43 0 0 170 249 1 1
MTM1 TBC1D8 0 0 0 309 1 1
MTM1 PTEN 0 0 284 338 1 2
MTM1 KLHL40 0 0 521 531 1 1
MTM1 TMEM35 0 0 74 180 1 1
MTM1 FEZ1 0 0 242 259 1 1
MTM1 STXBP5L 0 0 0 153 1 1
MTM1 ZNF566 0 0 0 248 1 1
MTM1 KIAA0226 0 0 0 225 1 1
MTM1 SLITRK4 0 0 155 154 1 1
MTM1 DNM1L 0 0 0 166 1 2
MTM1 PLN 0 0 125 185 1 1
MTM1 WIPI1 0 0 274 400 1 2
MTM1 PI4KB 0 650 181 739 1 1
MTM1 PTPRG 0 0 108 284 1 1
MTM1 ZNRF1 0 0 54 198 1 1
MTM1 ACBD4 0 0 181 181 1 1
MTM1 ABCB7 0 0 155 178 1 1
MTM1 ATP1A4 0 0 0 177 1 1
MTM1 MBNL1 0 0 124 275 1 1
MTM1 GMIP 0 0 151 263 1 1
MTM1 FKTN 0 0 213 213 1 1
MTM1 INPP4A 0 900 268 928 1 1
MTM1 OSBP 0 0 156 170 1 1
MTM1 BAI1 0 0 63 266 1 1
MTM1 BCOR 0 0 48 193 1 1
MTM1 INPP5A 0 0 213 213 1 1
MTM1 CHKB 0 0 180 229 1 1
MTM1 PIM2 0 0 0 205 1 1
MTM1 ESR1 0 0 52 161 1 2
MTM1 INPP5K 0 0 321 351 1 1
MTM1 UBQLN2 0 0 695 695 1 2
MTM1 TMEM55B 0 650 154 704 1 1
MTM1 TRPA1 0 0 329 329 1 1
MTM1 DGKA 0 0 94 178 1 1
MTM1 ECHDC3 0 0 140 510 1 1
MTM1 TOR1AIP1 0 0 142 323 1 1
MTM1 KSR1 0 0 73 246 1 1
MTM1 RNF114 0 0 0 453 1 1
MTM1 PTPRA 0 0 116 158 1 1
MTM1 PLCD1 0 650 90 698 1 1
MTM1 HLA-C 152 0 0 151 1 1
MTM1 SRD5A2 0 0 150 203 1 1
MTM1 ATP4A 0 0 0 200 1 1
MTM1 PLCD3 0 650 0 673 1 1
MTM1 SEPN1 0 0 504 524 1 1
MTM1 MCF2 0 0 52 159 1 1
MTM1 SNX6 83 0 150 220 1 1
MTM1 KCNN4 0 0 194 200 1 1
MTM1 ATP2B1 0 0 0 151 1 1
MTM1 NEB 0 0 269 269 1 1
MTM1 TSG101 0 0 0 151 1 2
MTM1 MTMR8 0 0 556 233 1 1
MTM1 AGFG1 0 0 163 169 1 1
MTM1 SERPINB5 0 0 193 193 1 1
MTM1 BTBD1 0 0 0 260 1 1
MTM1 ATP8A1 0 0 0 231 1 1
MTM1 PIP4K2C 0 650 46 662 1 1
MTM1 ANO5 0 0 294 299 1 1
MTM1 HNRNPDL 0 0 43 186 1 1
MTM1 MYH15 0 0 483 483 1 1
MTM1 MUSK 0 0 294 542 1 1
MTM1 IKBKG 0 0 95 175 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0019215 Molecular Function intermediate filament binding enables IDA
GO:0035091 Molecular Function phosphatidylinositol binding enables IDA
GO:0052629 Molecular Function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity enables IBA
GO:0052629 Molecular Function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity enables IDA
GO:0052629 Molecular Function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity enables TAS
GO:0004438 Molecular Function phosphatidylinositol-3-phosphate phosphatase activity enables IBA
GO:0004438 Molecular Function phosphatidylinositol-3-phosphate phosphatase activity enables IDA
GO:0004438 Molecular Function phosphatidylinositol-3-phosphate phosphatase activity enables TAS
GO:0004721 Molecular Function phosphoprotein phosphatase activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0031929 Biological Process TOR signaling involved_in IEA
GO:0000045 Biological Process autophagosome assembly involved_in IEA
GO:0008333 Biological Process endosome to lysosome transport involved_in IDA
GO:0045109 Biological Process intermediate filament organization involved_in IMP
GO:0048311 Biological Process mitochondrion distribution involved_in IBA
GO:0048311 Biological Process mitochondrion distribution involved_in IMP
GO:0070584 Biological Process mitochondrion morphogenesis involved_in IBA
GO:0070584 Biological Process mitochondrion morphogenesis involved_in IDA
GO:0046716 Biological Process muscle cell cellular homeostasis involved_in IBA
GO:0032007 Biological Process negative regulation of TOR signaling involved_in IEA
GO:1902902 Biological Process negative regulation of autophagosome assembly involved_in IBA
GO:0051898 Biological Process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IEA
GO:0032435 Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic process involved_in IEA
GO:0043491 Biological Process phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IEA
GO:0006661 Biological Process phosphatidylinositol biosynthetic process involved_in TAS
GO:0046856 Biological Process phosphatidylinositol dephosphorylation involved_in IBA
GO:0046856 Biological Process phosphatidylinositol dephosphorylation involved_in IDA
GO:0048633 Biological Process positive regulation of skeletal muscle tissue growth involved_in IEA
GO:0043161 Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process involved_in IEA
GO:0006470 Biological Process protein dephosphorylation involved_in IDA
GO:0015031 Biological Process protein transport involved_in IEA
GO:0044088 Biological Process regulation of vacuole organization involved_in IDA
GO:0048630 Biological Process skeletal muscle tissue growth involved_in IEA
GO:0031674 Cellular Component I band located_in IEA
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0030175 Cellular Component filopodium located_in IDA
GO:0005770 Cellular Component late endosome located_in IDA
GO:0016020 Cellular Component membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0001726 Cellular Component ruffle located_in IDA
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
PI Metabolism Reactome R-HSA-1483255
Phospholipid metabolism Reactome R-HSA-1483257
Synthesis of PIPs at the plasma membrane Reactome R-HSA-1660499
Synthesis of PIPs at the early endosome membrane Reactome R-HSA-1660516
Synthesis of PIPs at the late endosome membrane Reactome R-HSA-1660517
Metabolism of lipids Reactome R-HSA-556833
Phosphoinositides metabolism (WP4971) WikiPathways WP4971_r122106
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_047442132 1 mRNA transcript variant X1 NC_000023 Reference
XM_011531172 2 mRNA transcript variant X5 NC_000023 Reference
XM_047442133 1 mRNA transcript variant X2 NC_000023 Reference
XM_047442134 1 mRNA transcript variant X7 NC_000023 Reference
XM_017029548 2 mRNA transcript variant X6 NC_000023 Reference
NM_001376908 1 mRNA transcript variant 4 NC_000023 Reference
XM_011531171 2 mRNA transcript variant X4 NC_000023 Reference
NM_000252 3 mRNA transcript variant 5 NC_000023 Reference
NM_001376906 1 mRNA transcript variant 2 NC_000023 Reference
NM_001376907 1 mRNA transcript variant 3 NC_000023 Reference
XM_047442137 1 mRNA transcript variant X10 NC_000023 Reference
XM_047442135 1 mRNA transcript variant X8 NC_000023 Reference
XM_047442136 1 mRNA transcript variant X9 NC_000023 Reference
XM_017029547 1 mRNA transcript variant X3 NC_000023 Reference
XM_017029551 3 mRNA transcript variant X11 NC_000023 Reference