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OLR1

oxidized low density lipoprotein receptor 1
General Information
Name oxidized low density lipoprotein receptor 1
Alias
  • oxidized low-density lipoprotein receptor 1
  • C-type lectin domain family 8 member A
  • hLOX-1
  • lectin-type oxidized LDL receptor 1
  • ox LDL receptor 1
  • oxidized low density lipoprotein (lectin-like) receptor 1
  • oxidized low-density lipoprotein receptor 1, soluble form
  • scavenger receptor class E, member 1
Gene_family C-type lectin domain containing|Scavenger receptors
organism Homo sapiens
entrez_id 4973
location 12p13.2
transcript_count 6
exon_count 8
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
    Stringdb Oxidized low-density lipoprotein receptor 1; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reductio [...]
    nextProt Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
OLR1 BioGRID EZH2 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID PHLPP1 GeneID BioGRID Proximity Label-MS
OLR1 BioGRID CDC42 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOH GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOG GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RND3 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOC GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOB GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOA GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOV GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOU GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOJ GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOF GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RHOQ GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RND2 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RAC3 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RAC2 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID RAC1 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID F5 GeneID BioGRID Affinity Capture-MS
OLR1 BioGRID SYVN1 GeneID BioGRID Affinity Capture-Western; Co-localization
OLR1 BioGRID FBXL17 GeneID BioGRID Two-hybrid
OLR1 BioGRID KRAS GeneID BioGRID Proximity Label-MS
OLR1 BioGRID HRAS GeneID BioGRID Proximity Label-MS
OLR1 BioGRID CEL GeneID BioGRID Reconstituted Complex
OLR1 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
OLR1 Protein HSPA4 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
OLR1 CX3CR1 0 0 164 163 1 1
OLR1 ACAD10 0 0 0 223 1 1
OLR1 PTPRK 0 0 0 151 1 1
OLR1 PLAUR 0 0 134 153 1 1
OLR1 PMEL 0 0 204 204 1 1
OLR1 HSPA4 213 0 981 986 1 1
OLR1 LTF 0 0 211 239 1 1
OLR1 CETP 0 0 220 220 1 1
OLR1 PPARA 0 0 364 387 1 2
OLR1 LPL 0 0 358 372 1 1
OLR1 TEK 0 0 171 201 1 1
OLR1 DBR1 0 0 0 155 1 1
OLR1 HSP90B1 0 0 296 301 1 1
OLR1 CLEC12A 0 0 538 241 1 1
OLR1 CCR2 0 0 261 266 1 2
OLR1 CYCS 0 0 256 272 1 2
OLR1 TLR7 0 0 194 206 1 2
OLR1 VCAN 0 0 134 189 1 1
OLR1 CASP9 0 0 159 158 1 2
OLR1 ITGA8 0 0 94 189 1 1
OLR1 FASN 0 0 170 169 1 2
OLR1 FBLN5 0 0 181 203 1 1
OLR1 IL17A 0 0 225 224 1 2
OLR1 OLFM4 0 0 151 150 1 1
OLR1 AKR1B1 0 0 137 189 1 1
OLR1 PTPRS 0 0 0 151 1 1
OLR1 PTPN3 0 0 0 151 1 1
OLR1 EGF 0 0 242 241 1 2
OLR1 PRTN3 0 0 151 150 1 1
OLR1 CYP27A1 0 0 151 152 1 1
OLR1 MAPK8 0 0 134 155 1 2
OLR1 ARG1 0 0 362 375 1 2
OLR1 GCLC 0 0 127 187 1 1
OLR1 ADIPOQ 0 0 324 323 1 2
OLR1 KLRD1 0 0 574 197 1 1
OLR1 CLEC2A 0 0 575 575 1 1
OLR1 TBXA2R 0 0 166 165 1 1
OLR1 BOC 0 0 0 155 1 1
OLR1 EFEMP2 0 0 150 163 1 1
OLR1 STAB2 0 0 450 450 1 1
OLR1 VR1 0 0 67 160 1 1
OLR1 CEACAM8 0 0 324 349 1 1
OLR1 GPX4 0 0 66 163 1 2
OLR1 KLF5 0 0 101 172 1 2
OLR1 KLRF1 0 0 535 208 1 1
OLR1 CTGF 0 0 205 205 1 1
OLR1 CLEC1A 0 0 725 222 1 1
OLR1 GLB1 0 0 111 204 1 1
OLR1 LOXL2 0 0 212 270 1 1
OLR1 PIK3AP1 0 0 94 191 1 1
OLR1 ROCK2 0 0 427 437 1 1
OLR1 ABCA1 0 0 612 626 1 2
OLR1 IL1A 0 0 261 291 1 1
OLR1 CCL4 0 0 171 212 1 1
OLR1 FKBP4 0 0 305 305 1 1
OLR1 HMGCS2 0 0 154 238 1 1
OLR1 ABCA9 0 0 122 151 1 1
OLR1 HYOU1 0 0 289 334 1 1
OLR1 AGER 0 0 373 373 1 2
OLR1 CD33 0 0 244 253 1 1
OLR1 PTPRJ 0 0 0 151 1 1
OLR1 MFGE8 0 0 288 288 1 1
OLR1 SCARA5 0 0 207 207 1 1
OLR1 PLG 0 0 194 208 1 1
OLR1 SPPL2A 0 0 211 211 1 1
OLR1 IL4 0 0 303 303 1 1
OLR1 SCARB1 0 0 724 724 1 1
OLR1 CLEC2B 0 0 435 439 1 1
OLR1 OPRL1 0 0 457 462 1 1
OLR1 AMBP 0 0 74 228 1 1
OLR1 TNXB 0 0 71 184 1 1
OLR1 CD68 0 0 556 584 1 2
OLR1 CASP8 0 0 170 189 1 2
OLR1 ALB 0 0 379 402 1 2
OLR1 CCL2 0 0 556 578 1 2
OLR1 KNG1 0 0 193 193 1 1
OLR1 CD276 0 0 156 155 1 1
OLR1 TYROBP 0 0 95 195 1 1
OLR1 RESP18 0 0 0 151 1 1
OLR1 MME 0 0 94 204 1 1
OLR1 MOXD1 0 0 263 263 1 1
OLR1 PNPLA2 0 0 81 158 1 2
OLR1 HSP90AA1 0 0 675 680 1 2
OLR1 PTGDR 0 0 306 306 1 1
OLR1 LRRC3 0 0 108 156 1 1
OLR1 MBL2 0 0 220 220 1 1
OLR1 CLEC2D 0 0 268 166 1 1
OLR1 LAIR1 0 0 73 248 1 1
OLR1 CRP 0 0 985 985 1 2
OLR1 ACTB 0 0 392 402 1 2
OLR1 GAS6 0 0 261 261 1 1
OLR1 SELP 0 0 420 440 1 1
OLR1 INS 0 0 329 329 1 2
OLR1 TNNT1 0 0 228 227 1 1
OLR1 CD40 0 0 519 529 1 2
OLR1 SELL 0 0 151 150 1 1
OLR1 FPR2 0 0 312 329 1 1
OLR1 ABCG1 0 0 595 610 1 2
OLR1 ANGPT1 0 0 103 212 1 1
OLR1 SIRT3 0 0 93 234 1 2
OLR1 MAPK3 0 0 324 323 1 2
OLR1 MMP9 0 0 455 455 1 2
OLR1 FCGR2B 0 0 233 232 1 1
OLR1 PCK2 0 0 295 295 1 1
OLR1 SPP1 0 0 202 202 1 2
OLR1 RHOA 0 0 245 257 1 2
OLR1 AR 0 0 137 168 1 2
OLR1 FGL2 0 0 47 163 1 1
OLR1 CD1C 0 0 283 282 1 1
OLR1 HSPA8 0 0 155 393 1 2
OLR1 IFT122 0 0 137 151 1 1
OLR1 PLA2G1B 0 0 201 201 1 1
OLR1 KLRK1 0 0 415 169 1 1
OLR1 TLR5 0 0 180 192 1 1
OLR1 CXCL12 0 0 181 181 1 2
OLR1 TIMP1 0 0 234 250 1 1
OLR1 BAX 0 0 157 156 1 2
OLR1 ITGAV 0 0 139 168 1 1
OLR1 EHHADH 0 0 137 223 1 1
OLR1 PTPRC 0 0 205 297 1 1
OLR1 LOXL4 0 0 218 253 1 1
OLR1 CCT4 270 0 526 639 1 1
OLR1 ICAM1 0 0 594 607 1 2
OLR1 PTPRN 0 0 0 151 1 1
OLR1 PTPRO 0 0 0 151 1 1
OLR1 ABCG4 0 0 75 249 1 1
OLR1 APOLD1 0 0 126 352 1 1
OLR1 CHI3L2 0 0 154 153 1 1
OLR1 PRDX1 0 0 82 154 1 1
OLR1 ANGPTL6 0 0 0 157 1 1
OLR1 LAMP3 0 0 135 169 1 1
OLR1 CCR5 0 0 213 239 1 1
OLR1 SOD1 0 0 143 164 1 2
OLR1 ELOVL6 0 0 125 160 1 1
OLR1 CD8A 0 0 381 381 1 1
OLR1 CXorf49 0 0 217 225 1 1
OLR1 CALR 0 0 261 266 1 1
OLR1 SRA1 0 0 391 429 1 1
OLR1 SLC27A6 0 0 135 253 1 1
OLR1 MMP2 0 0 325 325 1 2
OLR1 TREM2 0 0 143 202 1 1
OLR1 ANGPT2 0 0 82 193 1 1
OLR1 CPNE2 0 0 94 185 1 1
OLR1 COL3A1 0 0 241 259 1 1
OLR1 ALOX15B 0 0 457 474 1 1
OLR1 SIGLEC14 0 0 166 165 1 1
OLR1 NOS1 0 0 167 180 1 1
OLR1 CASP1 0 0 232 269 1 2
OLR1 BAG5 0 0 328 328 1 1
OLR1 CYP7A1 0 0 203 217 1 1
OLR1 CXCL6 0 0 142 167 1 1
OLR1 PLAT 0 0 156 177 1 1
OLR1 PTPN21 0 0 0 151 1 1
OLR1 CAV1 0 0 217 217 1 2
OLR1 SRF 0 0 134 156 1 1
OLR1 HSPA1A 0 0 241 603 1 1
OLR1 SIGLEC1 0 0 136 189 1 1
OLR1 ENSG00000173366 0 0 293 304 1 1
OLR1 SERPINB2 0 0 93 181 1 1
OLR1 FABP3 0 0 162 179 1 1
OLR1 JUN 0 0 315 315 1 2
OLR1 GAPDH 0 0 381 381 1 2
OLR1 PTPN9 0 0 0 159 1 1
OLR1 TSPAN12 0 0 45 191 1 1
OLR1 ENO1 0 0 61 162 1 1
OLR1 SMAD2 0 0 127 162 1 2
OLR1 TLR4 0 0 590 610 1 2
OLR1 NOS2 0 0 183 205 1 2
OLR1 CX3CL1 0 0 181 181 1 1
OLR1 APOA1 0 0 465 517 1 1
OLR1 CD14 0 0 56 195 1 1
OLR1 CD83 0 0 250 268 1 1
OLR1 TLR10 0 0 72 165 1 1
OLR1 CLEC7A 0 0 558 209 1 1
OLR1 GSTM3 0 0 83 154 1 1
OLR1 PTPN14 0 0 0 151 1 1
OLR1 BCL2L1 0 0 181 181 1 2
OLR1 RELA 0 0 138 165 1 2
OLR1 HSPD1 0 0 831 831 1 1
OLR1 TAGLN 0 0 154 153 1 1
OLR1 ANXA5 0 0 287 286 1 2
OLR1 CLEC4D 0 0 391 194 1 1
OLR1 TSPAN11 0 0 0 189 1 1
OLR1 PPID 0 0 327 327 1 1
OLR1 HSPA1L 312 0 0 591 1 1
OLR1 HCST 0 0 99 282 1 1
OLR1 CCL5 0 0 242 258 1 2
OLR1 BIRC2 0 0 170 169 1 1
OLR1 IFNG 0 0 210 261 1 2
OLR1 APOA4 0 0 202 250 1 1
OLR1 IL6 0 0 517 541 1 2
OLR1 GPR37 0 0 320 319 1 1
OLR1 LYZ 0 0 90 188 1 1
OLR1 MPO 0 0 406 415 1 2
OLR1 UCP2 0 0 108 205 1 2
OLR1 TNFRSF1A 0 0 193 193 1 1
OLR1 BATF2 0 0 94 189 1 1
OLR1 STAT1 0 0 193 193 1 2
OLR1 PTGS1 0 0 173 205 1 1
OLR1 CD40LG 0 0 361 361 1 1
OLR1 SH3BP2 0 0 66 183 1 1
OLR1 MSH5 0 0 0 150 1 1
OLR1 MMP1 0 0 282 282 1 1
OLR1 PTPN13 0 0 0 151 1 1
OLR1 CXCR4 0 0 203 221 1 2
OLR1 SAA1 0 0 430 435 1 1
OLR1 CD163 0 0 288 329 1 1
OLR1 PTPRU 0 0 0 151 1 1
OLR1 MTOR 0 0 181 181 1 2
OLR1 TRPV1 0 0 67 160 1 2
OLR1 ALOXE3 0 0 134 173 1 1
OLR1 HRAS 174 0 74 215 1 2
OLR1 FCGR3A 0 0 218 246 1 1
OLR1 FCN3 0 0 45 161 1 1
OLR1 TMEM132E 0 0 115 175 1 1
OLR1 F5 179 0 0 179 1 1
OLR1 CXCR2 0 0 193 193 1 1
OLR1 OR10Z1 0 0 262 262 1 1
OLR1 IL1B 0 0 504 533 1 2
OLR1 CCT5 270 0 0 270 1 1
OLR1 NR1H3 0 0 309 358 1 1
OLR1 PYGL 0 0 70 174 1 1
OLR1 EDN1 0 0 458 462 1 1
OLR1 HIF1A 0 0 283 282 1 2
OLR1 PRKCB 0 0 202 225 1 2
OLR1 UQCRC2 0 0 306 306 1 1
OLR1 CXCL8 0 0 414 443 1 2
OLR1 ENSG00000268500 0 0 166 183 1 1
OLR1 STAB1 0 0 517 517 1 1
OLR1 DDOST 0 0 262 262 1 1
OLR1 CD151 0 0 57 261 1 1
OLR1 C1QTNF7 0 0 167 317 1 1
OLR1 C2orf40 0 0 465 465 1 1
OLR1 PTPRT 0 0 0 151 1 1
OLR1 SCNN1G 0 0 296 296 1 1
OLR1 STAT3 0 0 243 243 1 2
OLR1 PTPN22 0 0 47 177 1 1
OLR1 PTN 0 0 0 155 1 1
OLR1 PTX3 0 0 243 242 1 1
OLR1 PTPN4 0 0 0 151 1 1
OLR1 JAK2 0 0 134 167 1 2
OLR1 PPARD 0 0 101 187 1 1
OLR1 NR4A1 0 0 141 156 1 2
OLR1 CYBA 0 0 378 390 1 1
OLR1 GSTK1 0 0 0 155 1 1
OLR1 CARD9 0 0 162 161 1 1
OLR1 VAMP4 0 0 118 166 1 1
OLR1 PTPRD 0 0 0 151 1 1
OLR1 CSF3 0 0 225 224 1 1
OLR1 ADAT2 0 0 0 155 1 1
OLR1 DDIT3 0 0 193 193 1 2
OLR1 HMGCS1 0 0 120 154 1 1
OLR1 S100A1 0 0 306 306 1 1
OLR1 NR1H2 0 0 74 171 1 1
OLR1 TGM2 0 0 170 169 1 2
OLR1 ALOX15 0 0 529 529 1 1
OLR1 KLRC1 0 0 397 177 1 1
OLR1 LCN2 0 0 160 161 1 1
OLR1 TP53 0 0 228 227 1 2
OLR1 MYD88 0 0 329 329 1 2
OLR1 EGFR 0 0 157 156 1 2
OLR1 TAF1C 0 0 66 164 1 1
OLR1 ZNF423 0 0 358 369 1 1
OLR1 CEL 270 0 89 317 1 1
OLR1 CLEC1B 0 0 642 205 1 1
OLR1 NFE2L2 0 0 193 193 1 2
OLR1 TLR1 0 0 233 269 1 1
OLR1 PAPPA 0 0 184 183 1 1
OLR1 CH25H 0 0 208 225 1 1
OLR1 FUT4 0 0 324 325 1 1
OLR1 ASGR1 0 0 431 198 1 1
OLR1 CD80 0 0 252 268 1 2
OLR1 ALOX12 0 0 261 261 1 1
OLR1 CLEC4A 0 0 507 236 1 1
OLR1 ALOX12B 0 0 156 284 1 1
OLR1 SOAT1 0 0 370 370 1 1
OLR1 ACSL1 0 0 150 157 1 1
OLR1 LY75 0 0 504 510 1 1
OLR1 ANGPTL7 0 0 0 157 1 1
OLR1 NPC1 0 0 161 161 1 2
OLR1 APOH 0 0 227 232 1 1
OLR1 CD300A 0 0 102 158 1 1
OLR1 P4HB 0 0 81 180 1 2
OLR1 STOML1 0 0 0 212 1 1
OLR1 ACP5 0 0 71 160 1 1
OLR1 NR4A3 0 0 144 180 1 1
OLR1 IL18 0 0 287 286 1 2
OLR1 IFNA1 0 0 194 194 1 1
OLR1 ANGPTL5 0 0 0 157 1 1
OLR1 IL15 0 0 140 152 1 1
OLR1 MYC 0 0 166 165 1 2
OLR1 CLECL1 0 0 259 258 1 1
OLR1 PTPRN2 0 0 0 151 1 1
OLR1 DGAT1 0 0 167 167 1 2
OLR1 IL1R1 0 0 175 175 1 1
OLR1 ADAM10 0 0 187 187 1 1
OLR1 MFAP4 0 0 0 157 1 1
OLR1 PCK1 0 0 322 321 1 1
OLR1 TREM1 0 0 124 176 1 1
OLR1 PLTP 0 0 158 256 1 1
OLR1 SCARB2 0 0 324 323 1 1
OLR1 PTPN1 0 0 48 178 1 1
OLR1 RDH11 0 0 69 167 1 1
OLR1 PTPRZ1 0 0 0 172 1 1
OLR1 ELN 0 0 320 319 1 1
OLR1 APOA5 0 0 166 165 1 1
OLR1 SCARF1 0 0 701 701 1 1
OLR1 XBP1 0 0 168 167 1 2
OLR1 TLR8 0 0 181 219 1 1
OLR1 SCARF2 0 0 174 192 1 1
OLR1 APOC4 0 0 124 151 1 1
OLR1 PTPRA 0 0 0 151 1 1
OLR1 IFNB1 0 0 184 183 1 1
OLR1 DUOX2 0 0 276 282 1 1
OLR1 HMGB1 0 0 271 271 1 2
OLR1 ESR1 0 0 135 166 1 2
OLR1 ITGAM 0 0 340 368 1 1
OLR1 P2RY2 0 0 138 156 1 1
OLR1 SIRT1 0 0 344 349 1 2
OLR1 MYOCD 0 0 150 168 1 1
OLR1 PLIN2 0 0 155 154 1 2
OLR1 BAI1 0 0 218 218 1 1
OLR1 ACOX1 0 0 81 175 1 1
OLR1 NOX1 0 0 294 318 1 1
OLR1 TNR 0 0 0 181 1 1
OLR1 MMP13 0 0 140 176 1 2
OLR1 OSBPL9 0 0 252 268 1 1
OLR1 TIAL1 0 0 0 191 1 1
OLR1 KLRC2 0 0 388 176 1 1
OLR1 FN1 0 0 446 446 1 2
OLR1 GPX1 0 0 161 172 1 1
OLR1 CCR7 0 0 183 183 1 1
OLR1 LOXL3 0 0 145 184 1 1
OLR1 NCAM1 0 0 143 167 1 1
OLR1 ELANE 0 0 148 166 1 1
OLR1 PLAA 0 0 0 299 1 1
OLR1 PRKCA 0 0 172 184 1 1
OLR1 PTPRH 0 0 0 151 1 1
OLR1 ADAM17 0 0 228 227 1 1
OLR1 EIF2A 0 0 75 199 1 2
OLR1 ACSM4 0 0 108 244 1 1
OLR1 PTPRR 0 0 0 172 1 1
OLR1 HSPB1 0 0 174 173 1 2
OLR1 NCF2 0 0 217 247 1 1
OLR1 ENSG00000255819 0 0 415 169 1 1
OLR1 OBBP2 0 0 166 165 1 1
OLR1 AGL 0 0 0 206 1 1
OLR1 PTPRF 0 0 0 151 1 1
OLR1 COL1A1 0 0 174 184 1 2
OLR1 CXCL2 0 0 255 290 1 1
OLR1 IL10 0 0 394 407 1 2
OLR1 NR1H4 0 0 134 183 1 1
OLR1 TF 0 0 0 188 1 2
OLR1 RXRG 0 0 322 346 1 1
OLR1 SELE 0 0 460 479 1 1
OLR1 FCGR3B 0 0 219 219 1 1
OLR1 CCL3 0 0 243 281 1 1
OLR1 GOT2 0 0 306 306 1 1
OLR1 ICAM3 0 0 189 189 1 1
OLR1 LCAT 0 0 180 195 1 1
OLR1 THBD 0 0 324 323 1 1
OLR1 TOMM70A 0 0 357 357 1 1
OLR1 ITGA2B 0 0 167 178 1 1
OLR1 PTPN20A 0 0 0 172 1 1
OLR1 M6PR 161 0 134 242 1 1
OLR1 PON2 0 0 171 171 1 1
OLR1 MARCO 0 0 455 484 1 1
OLR1 SLC27A2 0 0 127 166 1 1
OLR1 FCGR2A 0 0 229 248 1 1
OLR1 SREBF1 0 0 233 232 1 1
OLR1 CXorf49B 0 0 217 225 1 1
OLR1 UCP1 0 0 122 182 1 2
OLR1 CLEC4E 0 0 310 182 1 1
OLR1 MAPK14 0 0 94 232 1 2
OLR1 FGB 0 0 72 185 1 1
OLR1 ANGPTL2 0 0 83 194 1 1
OLR1 NFKBIA 0 0 326 325 1 2
OLR1 KIT 0 0 123 155 1 2
OLR1 SYK 0 0 234 247 1 2
OLR1 LEP 0 0 272 272 1 1
OLR1 PTPRG 0 0 0 172 1 1
OLR1 SCARA3 0 0 211 211 1 1
OLR1 PDCD1LG2 0 0 92 241 1 1
OLR1 SEPT10 0 0 69 237 1 1
OLR1 NCOA6 0 0 303 303 1 1
OLR1 TREML4 0 0 124 162 1 1
OLR1 VEGFA 0 0 371 371 1 2
OLR1 NLRP3 0 0 323 357 1 2
OLR1 HSPA1B 0 0 43 499 1 1
OLR1 PLA2G7 0 0 242 275 1 1
OLR1 MMP14 0 0 919 921 1 1
OLR1 CXCL1 0 0 258 274 1 2
OLR1 TNN 0 0 0 181 1 1
OLR1 CLEC14A 0 0 181 181 1 1
OLR1 PTGS2 0 0 321 366 1 2
OLR1 DDX6 0 0 0 167 1 1
OLR1 F3 0 0 391 429 1 1
OLR1 ZSCAN26 0 0 96 271 1 1
OLR1 CASP3 0 0 390 390 1 2
OLR1 FCN2 0 0 113 221 1 1
OLR1 MSR1 0 0 635 657 1 1
OLR1 REN 0 0 340 362 1 1
OLR1 IL13 0 0 208 208 1 2
OLR1 ACE 0 0 325 329 1 1
OLR1 CYP46A1 0 0 220 220 1 1
OLR1 PTPN5 0 0 0 172 1 1
OLR1 ALOX5 0 0 324 345 1 1
OLR1 CXCL5 0 0 145 170 1 1
OLR1 FPR3 0 0 137 168 1 1
OLR1 CYBB 0 0 553 578 1 2
OLR1 GPX8 0 0 108 165 1 1
OLR1 ITGAX 0 0 282 318 1 1
OLR1 MRC1 0 0 323 346 1 1
OLR1 PTPN12 0 0 0 172 1 1
OLR1 MGP 0 0 241 241 1 1
OLR1 CXCL16 0 0 463 495 1 1
OLR1 GK 0 0 145 167 1 1
OLR1 FABP4 0 0 306 320 1 1
OLR1 ANGPTL3 0 0 124 258 1 1
OLR1 CHUK 0 0 135 168 1 1
OLR1 KLF2 0 0 193 207 1 1
OLR1 PNPLA3 0 0 82 197 1 1
OLR1 S100A12 0 0 183 201 1 1
OLR1 ITPKB 0 0 90 231 1 1
OLR1 SMPD1 0 0 326 325 1 1
OLR1 LAMB4 0 0 112 314 1 1
OLR1 CEBPB 0 0 167 185 1 2
OLR1 PTPRB 0 0 0 151 1 1
OLR1 CSF1 0 0 282 297 1 1
OLR1 LIPK 0 0 134 168 1 1
OLR1 CLEC9A 0 0 518 161 1 1
OLR1 FGL1 0 0 0 157 1 1
OLR1 TNC 0 0 66 202 1 1
OLR1 CCT7 270 0 0 270 1 1
OLR1 PTPN11 0 0 120 238 1 1
OLR1 DDAH1 0 0 107 161 1 1
OLR1 PTPN18 0 0 0 172 1 1
OLR1 PON1 0 0 455 481 1 1
OLR1 ANGPTL4 0 0 141 305 1 1
OLR1 ARHGEF1 0 0 422 422 1 1
OLR1 HSPA5 0 0 193 251 1 2
OLR1 ZC3H10 0 0 106 243 1 1
OLR1 SOD2 0 0 172 208 1 2
OLR1 KRAS 175 0 47 193 1 2
OLR1 ITGB2 0 0 193 193 1 1
OLR1 ARMC6 0 0 112 152 1 1
OLR1 LRP1 0 0 682 682 1 1
OLR1 ANXA1 0 0 164 182 1 1
OLR1 PRKCSH 0 0 235 235 1 1
OLR1 TLR6 0 0 242 270 1 1
OLR1 IL2 0 0 210 210 1 1
OLR1 SDC1 0 0 108 174 1 1
OLR1 THBS1 0 0 193 210 1 1
OLR1 ABCB1 0 0 113 153 1 2
OLR1 BECN1 0 0 186 186 1 2
OLR1 CCL7 0 0 96 154 1 1
OLR1 PICK1 0 0 58 170 1 1
OLR1 TLR2 0 0 669 704 1 2
OLR1 ANGPT4 0 0 0 157 1 1
OLR1 LILRA4 0 0 150 155 1 1
OLR1 FCN1 0 0 143 266 1 1
OLR1 SPATA6 0 0 166 165 1 1
OLR1 CD86 0 0 288 315 1 1
OLR1 ACOX3 0 0 66 172 1 1
OLR1 RXRB 0 0 306 331 1 1
OLR1 PPP1R3A 0 0 50 151 1 1
OLR1 ESM1 0 0 151 150 1 1
OLR1 FMOD 0 0 45 163 1 1
OLR1 NOX4 0 0 457 457 1 2
OLR1 CFH 0 0 155 164 1 1
OLR1 DCTN5 0 0 0 155 1 1
OLR1 DUOX1 0 0 288 293 1 1
OLR1 KLF4 0 0 181 195 1 2
OLR1 IKBKB 0 0 203 217 1 2
OLR1 ACE2 0 0 166 218 1 2
OLR1 SPPL2B 0 0 183 183 1 1
OLR1 VCAM1 0 0 601 623 1 1
OLR1 CCL16 0 0 0 187 1 1
OLR1 INPP5D 0 0 0 187 1 1
OLR1 CD4 0 0 365 376 1 2
OLR1 PPARG 0 0 470 489 1 2
OLR1 AKT1 0 0 404 414 1 2
OLR1 CPT1A 0 0 180 185 1 1
OLR1 LY96 0 0 159 166 1 1
OLR1 CSF2 0 0 358 358 1 1
OLR1 FOXF1 0 0 0 201 1 1
OLR1 ARG2 0 0 324 338 1 1
OLR1 ECE1 0 0 126 160 1 1
OLR1 CD34 0 0 181 181 1 2
OLR1 FBXL17 192 0 0 192 1 1
OLR1 CD1D 0 0 181 181 1 1
OLR1 VLDLR 0 0 259 258 1 1
OLR1 CLEC12B 0 0 556 179 1 1
OLR1 FBN1 0 0 167 180 1 1
OLR1 TLR9 0 0 294 305 1 2
OLR1 HSP90AB1 0 0 48 157 1 2
OLR1 AXL 0 0 136 151 1 2
OLR1 DLD 0 0 0 166 1 2
OLR1 PTPN23 0 0 0 172 1 1
OLR1 FGG 0 0 73 186 1 1
OLR1 CXCL10 0 0 181 198 1 2
OLR1 LPA 0 0 171 185 1 1
OLR1 APOA2 0 0 108 213 1 1
OLR1 SIRPB2 0 0 161 199 1 1
OLR1 A2M 0 0 246 268 1 1
OLR1 TAF2 0 0 0 155 1 1
OLR1 EIF2AK3 0 0 155 154 1 2
OLR1 PTPRM 0 0 0 151 1 1
OLR1 MED20 0 0 260 260 1 1
OLR1 LGALS3 0 0 255 271 1 2
OLR1 FRMPD2 0 0 0 159 1 1
OLR1 HRH1 0 0 84 181 1 1
OLR1 SCAF4 0 0 135 167 1 1
OLR1 TLR3 0 0 282 293 1 2
OLR1 FLT1 0 0 151 233 1 1
OLR1 CADM1 0 0 196 196 1 1
OLR1 SCD 0 0 180 268 1 1
OLR1 IRF8 0 0 137 224 1 1
OLR1 SRC 0 0 246 259 1 2
OLR1 TIMM44 0 0 415 414 1 1
OLR1 CCT3 270 0 48 276 1 1
OLR1 CD47 0 0 141 180 1 2
OLR1 EEA1 161 0 123 232 1 2
OLR1 MB 0 0 170 188 1 2
OLR1 PLB1 0 0 57 239 1 1
OLR1 PCSK9 0 0 542 542 1 1
OLR1 APOE 0 0 634 674 1 2
OLR1 HSD17B2 0 0 61 205 1 1
OLR1 ABCD3 0 0 0 373 1 1
OLR1 OR6K3 0 0 155 154 1 1
OLR1 TGFB1 0 0 204 216 1 2
OLR1 AGTR2 0 0 235 235 1 1
OLR1 ADSSL1 0 0 81 174 1 1
OLR1 KLRB1 0 0 388 166 1 1
OLR1 PTPN7 0 0 0 172 1 1
OLR1 KDR 0 0 171 216 1 2
OLR1 PTPRQ 0 0 0 151 1 1
OLR1 MGST1 0 0 45 256 1 1
OLR1 PTPN6 0 0 0 151 1 1
OLR1 APOC2 0 0 107 182 1 1
OLR1 H2AFJ 0 0 0 171 1 1
OLR1 FOXP3 0 0 171 183 1 2
OLR1 HMOX1 0 0 358 358 1 2
OLR1 FGA 0 0 66 179 1 1
OLR1 CLEC5A 0 0 261 319 1 1
OLR1 PECAM1 0 0 260 260 1 1
OLR1 CAT 0 0 321 326 1 2
OLR1 CCT6A 270 0 45 273 1 1
OLR1 TXN 0 0 164 163 1 1
OLR1 DEFA1 0 0 164 163 1 1
OLR1 FADS2 0 0 150 227 1 1
OLR1 FADS1 0 0 97 193 1 1
OLR1 ENSG00000264813 0 0 325 329 1 1
OLR1 AOX1 0 0 67 185 1 1
OLR1 FCAR 0 0 95 233 1 1
OLR1 PTPN2 0 0 0 172 1 2
OLR1 COLEC12 0 0 405 405 1 1
OLR1 LDLR 0 0 529 529 1 2
OLR1 CHIT1 0 0 183 200 1 1
OLR1 CTLA4 0 0 193 193 1 2
OLR1 SREBF2 0 0 267 279 1 1
OLR1 CD274 0 0 180 227 1 2
OLR1 TIMD4 0 0 320 334 1 1
OLR1 LOXL1 0 0 310 357 1 1
OLR1 CD36 0 0 275 275 1 2
OLR1 NOS3 0 0 608 614 1 2
OLR1 ACTA2 0 0 114 169 1 1
OLR1 NCF1 0 0 414 453 1 1
OLR1 PTAFR 0 0 184 201 1 1
OLR1 FIBCD1 0 0 0 157 1 1
OLR1 ICAM2 0 0 124 159 1 1
OLR1 PTPRE 0 0 0 151 1 1
OLR1 CD19 0 0 144 168 1 1
OLR1 NOX5 0 0 131 163 1 1
OLR1 EDNRA 0 0 166 165 1 1
OLR1 HMGCR 0 0 295 295 1 1
OLR1 LIPA 0 0 255 254 1 1
OLR1 CD207 0 0 395 406 1 1
OLR1 LOX 0 0 761 761 1 2
OLR1 IRS1 0 0 134 153 1 2
OLR1 FCGR1A 0 0 218 246 1 1
OLR1 AGTR1 0 0 541 541 1 1
OLR1 RPS9 0 0 0 222 1 1
OLR1 SERPINE1 0 0 336 362 1 1
OLR1 PLA2G3 0 0 67 386 1 1
OLR1 APOB 0 600 882 950 1 2
OLR1 CSF1R 0 0 143 199 1 1
OLR1 IGF1 0 0 181 181 1 2
OLR1 FABP1 0 0 161 178 1 1
OLR1 MERTK 0 0 286 298 1 1
OLR1 CHID1 0 0 156 155 1 1
OLR1 KLRC4 0 0 270 270 1 1
OLR1 CDH5 0 0 150 163 1 1
OLR1 RETN 0 0 205 228 1 1
OLR1 CXCL3 0 0 140 158 1 1
OLR1 FGF2 0 0 172 171 1 2
OLR1 MMP8 0 0 175 211 1 1
OLR1 GPNMB 0 0 161 183 1 1
OLR1 TNFAIP6 0 0 135 166 1 1
OLR1 AGT 0 0 45 231 1 1
OLR1 VWF 0 0 289 288 1 1
OLR1 TNFAIP3 0 0 150 188 1 2
OLR1 TCP1 270 0 95 311 1 1
OLR1 GSTP1 0 0 53 152 1 1
OLR1 APOC3 0 0 286 286 1 1
OLR1 ACADM 0 0 95 211 1 1
OLR1 MMP7 0 0 91 153 1 1
OLR1 CD209 0 0 458 176 1 1
OLR1 PON3 0 0 194 194 1 1
OLR1 CD44 0 0 181 225 1 2
OLR1 ANGPTL1 0 0 43 159 1 1
OLR1 MMP3 0 0 293 293 1 1
OLR1 IL1RN 0 0 108 165 1 1
OLR1 UCP3 0 0 52 216 1 1
OLR1 HNRNPD 0 0 304 304 1 1
OLR1 PLA2G2A 0 0 157 156 1 1
OLR1 TNF 0 0 520 549 1 2
OLR1 HSPA2 0 0 431 551 1 1
OLR1 XDH 0 0 0 203 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0030246 Molecular Function carbohydrate binding enables IEA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0005041 Molecular Function low-density lipoprotein particle receptor activity enables IBA
GO:0005515 Molecular Function protein binding enables IPI
GO:0008015 Biological Process blood circulation involved_in TAS
GO:0006897 Biological Process endocytosis involved_in IEA
GO:0002376 Biological Process immune system process involved_in IEA
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0007159 Biological Process leukocyte cell-cell adhesion involved_in IBA
GO:0042157 Biological Process lipoprotein metabolic process involved_in IBA
GO:0006508 Biological Process proteolysis involved_in TAS
GO:0005576 Cellular Component extracellular region located_in IEA
GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
GO:0016020 Cellular Component membrane located_in TAS
GO:0045121 Cellular Component membrane raft located_in IEA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005886 Cellular Component plasma membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0043235 Cellular Component receptor complex part_of IBA
GO:0043235 Cellular Component receptor complex part_of IDA
GO:0035579 Cellular Component specific granule membrane located_in TAS
GO:0070821 Cellular Component tertiary granule membrane located_in TAS
Pathways
Name DB ID
Hemostasis Reactome R-HSA-109582
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Cell surface interactions at the vascular wall Reactome R-HSA-202733
Neutrophil degranulation Reactome R-HSA-6798695
PPAR signaling pathway (WP3942) WikiPathways WP3942_r106517
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_047428907 1 mRNA transcript variant X1 NC_000012 Reference
NM_001172632 2 mRNA transcript variant 2 NC_000012 Reference
NM_001172633 2 mRNA transcript variant 3 NC_000012 Reference
NM_002543 4 mRNA transcript variant 1 NC_000012 Reference
XM_047428909 1 mRNA transcript variant X3 NC_000012 Reference
XM_047428908 1 mRNA transcript variant X2 NC_000012 Reference