HAdb 2.0 is available now!

NOX4

NADPH oxidase 4
General Information
Name NADPH oxidase 4
Alias
  • NADPH oxidase 4
  • kidney oxidase-1
  • kidney superoxide-producing NADPH oxidase
  • renal NAD(P)H-oxidase
Gene_family
organism Homo sapiens
entrez_id 50507
location 11q14.3
transcript_count 9
exon_count 26
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
    Stringdb NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and is [...]
    nextProt Display reduced activity.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
NOX4 BioGRID CYBA GeneID BioGRID Affinity Capture-Western
NOX4 BioGRID MUC5B GeneID BioGRID Affinity Capture-MS
NOX4 BioGRID BPIFB1 GeneID BioGRID Affinity Capture-MS
NOX4 BioGRID PIGR GeneID BioGRID Affinity Capture-MS
NOX4 BioGRID JCHAIN GeneID BioGRID Affinity Capture-MS
NOX4 BioGRID HP GeneID BioGRID Affinity Capture-MS
NOX4 BioGRID SIRPA GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOX4 BioGRID PTPN11 GeneID BioGRID Reconstituted Complex
NOX4 BioGRID CYLD GeneID BioGRID Affinity Capture-Western
NOX4 BioGRID MYO18A GeneID BioGRID Affinity Capture-MS
NOX4 BioGRID ACTBL2 GeneID BioGRID Affinity Capture-MS
NOX4 Protein TLR4 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
NOX4 FOXO4 0 0 233 232 1 1
NOX4 SYCN 0 0 0 177 1 1
NOX4 EIF4EBP1 0 0 180 268 1 2
NOX4 CYLD 270 0 460 626 1 1
NOX4 EDNRB 0 0 210 215 1 1
NOX4 CETN1 0 0 0 167 1 1
NOX4 SLC39A11 0 0 0 188 1 1
NOX4 CXCL10 0 0 143 162 1 2
NOX4 SEPP1 0 0 174 190 1 1
NOX4 GPT 0 0 261 261 1 1
NOX4 CERS4 0 0 0 212 1 1
NOX4 IL11 0 0 241 240 1 1
NOX4 PDE5A 0 0 181 186 1 1
NOX4 SLC31A1 0 0 0 267 1 1
NOX4 PINK1 0 0 235 235 1 2
NOX4 NFATC4 0 0 81 206 1 1
NOX4 GSK3A 0 0 0 157 1 1
NOX4 SLC12A1 0 0 150 284 1 1
NOX4 SIRT4 0 0 287 286 1 1
NOX4 GUCA1A 0 0 0 167 1 1
NOX4 GJA1 0 0 261 261 1 1
NOX4 ENSG00000274276 0 0 298 303 1 1
NOX4 PRDX3 0 0 341 382 1 1
NOX4 CD34 0 0 203 203 1 2
NOX4 ERBB2 0 0 138 156 1 2
NOX4 ARG2 0 0 157 156 1 1
NOX4 CYP2C19 0 0 53 259 1 1
NOX4 TH 0 0 168 167 1 2
NOX4 LTB4R 0 0 134 157 1 1
NOX4 CYP2J2 0 0 0 359 1 1
NOX4 SCGN 0 0 0 210 1 1
NOX4 GSTA2 0 0 155 165 1 1
NOX4 HAO1 0 0 90 178 1 1
NOX4 GUCA1B 0 0 0 167 1 1
NOX4 EFCAB13 0 0 0 210 1 1
NOX4 FBN1 0 0 119 152 1 1
NOX4 TLR9 0 0 155 170 1 2
NOX4 SLC22A31 0 0 0 157 1 1
NOX4 CA9 0 0 99 162 1 1
NOX4 CD4 0 0 181 181 1 2
NOX4 ISCU 0 0 73 170 1 1
NOX4 ATF4 0 0 218 218 1 2
NOX4 VCAM1 0 0 517 538 1 1
NOX4 UQCRFS1 0 0 156 235 1 1
NOX4 NOSIP 0 0 63 164 1 1
NOX4 AKT1 0 0 772 783 1 2
NOX4 CPT1A 0 0 162 161 1 1
NOX4 CAPN1 0 0 150 180 1 2
NOX4 ETF1 0 0 0 185 1 1
NOX4 TGFB2 0 0 248 248 1 1
NOX4 PPARG 0 0 508 515 1 2
NOX4 NPDC1 0 0 0 164 1 1
NOX4 CYP2A7 0 0 0 212 1 1
NOX4 NADK 0 0 68 192 1 1
NOX4 STAG3 0 0 0 163 1 1
NOX4 CST3 0 0 166 166 1 1
NOX4 DROSHA 0 0 134 162 1 1
NOX4 XIAP 0 0 112 151 1 2
NOX4 PPP2R4 0 0 151 150 1 1
NOX4 ZKSCAN7 0 0 225 225 1 1
NOX4 RUNX2 0 0 230 229 1 2
NOX4 INSL5 0 0 0 177 1 1
NOX4 ATP7A 0 0 0 216 1 1
NOX4 COL1A2 0 0 184 235 1 1
NOX4 ATF6 0 0 310 309 1 2
NOX4 ACE2 0 0 427 449 1 2
NOX4 SLC26A6 0 0 112 167 1 1
NOX4 IKBKB 0 0 293 337 1 2
NOX4 DUOX1 0 540 879 733 1 1
NOX4 KLF4 0 0 208 214 1 2
NOX4 LRRC8C 0 0 54 196 1 1
NOX4 RAC2 0 0 519 549 1 1
NOX4 TOMM20 0 0 122 182 1 2
NOX4 CYP2C9 0 0 62 266 1 1
NOX4 AGTR2 0 0 251 296 1 1
NOX4 EIF2S1 0 0 218 218 1 2
NOX4 MMP12 0 0 137 175 1 1
NOX4 KDR 0 0 693 839 1 2
NOX4 HMOX1 0 0 619 645 1 2
NOX4 MGST1 0 0 67 246 1 1
NOX4 ASPN 0 0 48 173 1 1
NOX4 ADIPOR2 0 0 134 152 1 1
NOX4 CYP4V2 0 0 0 246 1 1
NOX4 EFCAB7 0 0 0 210 1 1
NOX4 GLRX 0 0 451 471 1 1
NOX4 RIPK3 0 0 81 210 1 2
NOX4 PRKCD 0 0 289 288 1 2
NOX4 TRPV4 0 0 123 154 1 1
NOX4 CYP2D6 0 0 0 189 1 1
NOX4 CNN1 0 0 151 150 1 1
NOX4 CDKN1B 0 0 140 175 1 2
NOX4 CLCN7 0 0 43 192 1 1
NOX4 SLC25A13 0 0 63 204 1 1
NOX4 STAT5B 0 900 150 911 1 1
NOX4 RASGRF2 0 0 0 204 1 1
NOX4 TSC2 0 0 174 192 1 2
NOX4 VDAC1 0 0 241 256 1 2
NOX4 TGFB1 0 0 371 534 1 2
NOX4 SRC 0 0 598 630 1 2
NOX4 SCD 0 0 181 181 1 1
NOX4 LRRC15 0 0 95 152 1 1
NOX4 CDC42 0 0 199 240 1 2
NOX4 F2 0 0 0 188 1 1
NOX4 CYP11B1 0 0 64 173 1 1
NOX4 GPX6 0 0 184 444 1 1
NOX4 MKL1 0 0 543 543 1 1
NOX4 MB 0 0 123 177 1 2
NOX4 MCU 0 0 211 211 1 2
NOX4 BGLAP 0 0 151 150 1 1
NOX4 EEA1 0 0 66 152 1 2
NOX4 ACTG2 0 0 140 211 1 1
NOX4 TNFSF11 0 0 210 227 1 2
NOX4 APOE 0 0 504 512 1 2
NOX4 PCSK9 0 0 107 182 1 1
NOX4 SLC2A4 0 0 325 336 1 1
NOX4 VDAC3 0 0 170 169 1 1
NOX4 FOXO3 0 0 351 355 1 2
NOX4 EIF2AK3 0 0 336 336 1 2
NOX4 ENSG00000167377 0 0 767 767 1 1
NOX4 STAT6 0 0 134 173 1 1
NOX4 SRXN1 0 0 255 301 1 1
NOX4 FMO2 0 0 181 246 1 1
NOX4 TLR3 0 0 154 169 1 2
NOX4 TESC 0 0 0 170 1 1
NOX4 DNMBP 0 0 0 156 1 1
NOX4 CIB1 0 0 0 170 1 1
NOX4 LGALS3 0 0 228 229 1 2
NOX4 MIF 0 0 123 157 1 2
NOX4 EFCAB11 0 0 0 210 1 1
NOX4 VHL 0 0 257 257 1 2
NOX4 CADM1 0 0 170 169 1 1
NOX4 FLT1 0 0 160 218 1 1
NOX4 EDNRA 0 0 256 256 1 1
NOX4 NTRK1 0 0 120 160 1 1
NOX4 HMGCR 0 0 167 167 1 1
NOX4 NOX5 0 540 965 697 1 1
NOX4 CYP24A1 0 0 0 152 1 1
NOX4 SAG 0 0 138 157 1 1
NOX4 SGK1 0 0 131 172 1 2
NOX4 IRS1 0 0 325 325 1 2
NOX4 LOX 0 0 325 345 1 2
NOX4 PGC 0 0 0 183 1 1
NOX4 RPS6KB1 0 0 241 240 1 2
NOX4 SLC7A8 0 0 0 156 1 1
NOX4 REM1 0 0 0 216 1 1
NOX4 AGTR1 0 0 650 657 1 1
NOX4 APOL2 0 0 0 157 1 1
NOX4 AHR 0 0 142 183 1 2
NOX4 SERPINE1 0 0 469 480 1 1
NOX4 PRKAA1 0 0 48 161 1 2
NOX4 SMTNL2 0 0 0 363 1 1
NOX4 ALDH2 0 0 183 215 1 2
NOX4 SREBF2 0 0 161 167 1 1
NOX4 CCND1 0 0 294 309 1 2
NOX4 ACTA2 0 0 212 416 1 1
NOX4 NOS3 0 0 731 741 1 2
NOX4 JUND 0 0 142 166 1 1
NOX4 TMX3 0 0 166 240 1 1
NOX4 SERPINE2 0 0 72 204 1 1
NOX4 MYL2 0 0 103 221 1 1
NOX4 NCF1 0 540 903 966 1 1
NOX4 CYP20A1 0 0 0 157 1 1
NOX4 RHEB 0 0 122 159 1 2
NOX4 AHCTF1 0 0 0 489 1 1
NOX4 HPRT1 0 0 195 195 1 1
NOX4 SLC7A13 0 0 0 156 1 1
NOX4 SPRY1 0 0 134 175 1 1
NOX4 HPCA 0 0 0 167 1 1
NOX4 PTPN2 0 0 81 212 1 2
NOX4 PRKRIR 0 0 55 155 1 1
NOX4 MDK 0 0 572 572 1 1
NOX4 ELL 0 0 52 298 1 1
NOX4 CYP4F22 0 0 0 294 1 1
NOX4 LDLR 0 0 261 261 1 2
NOX4 SV2B 0 0 0 157 1 1
NOX4 SLC27A1 0 0 439 439 1 1
NOX4 ATP2A2 0 0 141 264 1 1
NOX4 PECAM1 0 0 342 348 1 1
NOX4 CAT 0 0 738 793 1 2
NOX4 PTK2B 0 0 241 264 1 1
NOX4 NKX2-5 0 0 152 151 1 1
NOX4 DUSP6 0 0 448 491 1 1
NOX4 TSSK2 0 0 0 154 1 1
NOX4 PDPK1 0 0 139 172 1 2
NOX4 CYC1 0 0 47 193 1 1
NOX4 MEMO1 0 0 46 181 1 1
NOX4 FH 0 0 184 204 1 1
NOX4 NPHS2 0 0 430 434 1 2
NOX4 BMPR2 0 0 194 230 1 1
NOX4 CANX 0 0 250 259 1 2
NOX4 TXN 0 0 528 568 1 1
NOX4 ENSG00000264813 0 0 506 539 1 1
NOX4 AOX1 0 0 92 196 1 1
NOX4 LRP2BP 0 0 0 161 1 1
NOX4 GCH1 0 0 243 244 1 1
NOX4 TRAF3IP2 0 0 193 193 1 1
NOX4 HGF 0 0 211 211 1 2
NOX4 ENSG00000258973 0 0 0 176 1 1
NOX4 TSNAX 0 0 52 158 1 1
NOX4 KIAA0141 0 0 0 161 1 1
NOX4 NT5E 0 0 112 201 1 1
NOX4 MEF2C 0 0 208 208 1 1
NOX4 CD44 0 0 206 206 1 2
NOX4 C6 0 0 88 166 1 1
NOX4 TNNC2 0 0 0 210 1 1
NOX4 UCP3 0 0 233 233 1 1
NOX4 CABP1 0 0 0 210 1 1
NOX4 WISP1 0 0 150 169 1 1
NOX4 STAG1 0 0 0 163 1 1
NOX4 MMP3 0 0 180 262 1 1
NOX4 TNF 0 0 561 588 1 2
NOX4 SMARCD1 0 0 0 161 1 1
NOX4 SEL1L3 0 0 0 161 1 1
NOX4 XDH 0 0 260 591 1 1
NOX4 HSPA2 0 0 0 162 1 1
NOX4 CBSL 0 0 299 304 1 1
NOX4 SLC7A11 0 0 207 302 1 2
NOX4 RBFOX3 0 0 166 165 1 1
NOX4 TSSK1B 0 0 0 154 1 1
NOX4 NFAT5 0 0 92 156 1 1
NOX4 PPP1R15A 0 0 785 785 1 2
NOX4 SLC22A14 0 0 0 157 1 1
NOX4 MIOX 0 0 219 237 1 1
NOX4 MMP7 0 0 155 200 1 1
NOX4 FIS1 0 0 242 241 1 2
NOX4 ACADM 0 0 97 163 1 1
NOX4 RCAN1 0 0 107 274 1 2
NOX4 SLC22A7 0 0 0 157 1 1
NOX4 VCL 0 0 204 204 1 1
NOX4 CNGA2 0 0 0 163 1 1
NOX4 CYP2A6 0 0 44 215 1 1
NOX4 THRSP 0 0 0 438 1 1
NOX4 NPR3 0 0 172 171 1 1
NOX4 PRDX4 0 0 342 383 1 1
NOX4 FGF2 0 0 294 294 1 2
NOX4 GLRX2 0 0 241 268 1 1
NOX4 NFE2L3 0 0 243 265 1 1
NOX4 MMP8 0 0 92 186 1 1
NOX4 SV2C 0 0 0 157 1 1
NOX4 TXNIP 0 0 459 462 1 2
NOX4 SFRP4 0 0 92 164 1 1
NOX4 PRDX2 0 0 218 302 1 1
NOX4 VWF 0 0 260 260 1 1
NOX4 AGT 0 0 266 603 1 1
NOX4 CYB5R3 0 0 75 156 1 1
NOX4 CCND2 0 0 69 164 1 1
NOX4 GSTP1 0 0 193 210 1 1
NOX4 MYL4 0 0 90 210 1 1
NOX4 ATG4B 0 0 125 157 1 2
NOX4 CALN1 0 0 0 210 1 1
NOX4 TNNT2 0 0 95 190 1 1
NOX4 GCG 0 0 242 241 1 1
NOX4 POTEI 0 0 0 153 1 1
NOX4 ANAPC2 0 0 0 213 1 1
NOX4 MAPK1 0 0 161 208 1 2
NOX4 IGF1 0 0 391 399 1 2
NOX4 APOB 0 0 167 167 1 2
NOX4 PARP3 0 0 90 252 1 1
NOX4 MMP27 0 0 0 202 1 1
NOX4 THBS2 0 0 124 157 1 1
NOX4 ATOX1 0 0 83 303 1 1
NOX4 PKM 0 0 199 199 1 1
NOX4 AGTRAP 0 0 122 311 1 1
NOX4 CDH5 0 0 323 323 1 1
NOX4 RETN 0 0 427 427 1 1
NOX4 ATF3 0 0 170 226 1 2
NOX4 HAND2 0 0 53 154 1 1
NOX4 SPHK1 0 0 135 174 1 2
NOX4 HMOX2 0 0 341 386 1 1
NOX4 ADAM17 0 0 241 240 1 1
NOX4 CNGA4 0 0 0 163 1 1
NOX4 MAP1LC3B 0 0 173 173 1 2
NOX4 TIMP2 0 0 149 180 1 1
NOX4 SPHK2 0 0 136 152 1 1
NOX4 ERP27 0 0 54 152 1 1
NOX4 CYP2C8 0 0 0 249 1 1
NOX4 TERT 0 0 146 164 1 2
NOX4 AGL 0 0 0 303 1 1
NOX4 HSPB2 0 0 210 210 1 1
NOX4 KCNN4 0 0 170 171 1 1
NOX4 CMA1 0 0 170 169 1 1
NOX4 HSPB1 0 0 211 211 1 2
NOX4 NCF2 0 540 834 943 1 1
NOX4 TGFBR1 0 0 338 368 1 1
NOX4 GALC 0 0 0 261 1 1
NOX4 S100A4 0 0 161 161 1 1
NOX4 MMP13 0 0 161 161 1 2
NOX4 MPST 0 0 167 186 1 1
NOX4 GPX1 0 0 595 631 1 1
NOX4 FN1 0 0 557 569 1 2
NOX4 MT-CYB 0 0 267 280 1 1
NOX4 LRRC8D 0 0 66 153 1 1
NOX4 CYP11B2 0 0 219 310 1 1
NOX4 ULK1 0 0 95 151 1 2
NOX4 SOD3 0 0 530 629 1 1
NOX4 ATP5G1 0 0 96 152 1 1
NOX4 CERS3 0 0 0 212 1 1
NOX4 SEL1L 0 0 0 161 1 1
NOX4 PRKCA 0 0 331 331 1 1
NOX4 GPX3 0 0 427 515 1 1
NOX4 PIM2 0 0 0 154 1 1
NOX4 ESR1 0 0 190 207 1 2
NOX4 RAC1 0 0 273 310 1 2
NOX4 HMGB1 0 0 273 273 1 2
NOX4 DUOX2 0 540 806 730 1 1
NOX4 TXNDC5 0 0 112 156 1 1
NOX4 CTSK 0 0 123 210 1 2
NOX4 RCVRN 0 0 0 167 1 1
NOX4 SMARCD2 0 0 0 161 1 1
NOX4 SMAD7 0 0 323 323 1 1
NOX4 ACTBL2 130 0 0 150 1 1
NOX4 MYL3 0 0 97 216 1 1
NOX4 TRPA1 0 0 150 203 1 1
NOX4 ITGAM 0 0 264 271 1 1
NOX4 MAP3K5 0 0 469 484 1 1
NOX4 MCL1 0 0 146 153 1 2
NOX4 SIRT1 0 0 517 532 1 2
NOX4 MYOCD 0 0 385 384 1 1
NOX4 PLIN2 0 0 95 192 1 2
NOX4 LMNB1 0 0 141 164 1 1
NOX4 NOX1 0 800 986 871 1 1
NOX4 ACOX1 0 0 499 499 1 1
NOX4 GATA6 0 0 123 174 1 1
NOX4 SLC22A5 0 0 0 157 1 1
NOX4 MT1G 0 0 76 152 1 1
NOX4 ELN 0 0 342 342 1 1
NOX4 PTPN1 0 900 519 951 1 1
NOX4 PUM1 0 0 0 163 1 1
NOX4 XBP1 0 0 265 274 1 2
NOX4 ARHGAP28 0 0 0 207 1 1
NOX4 UGGT2 0 0 52 166 1 1
NOX4 YAP1 0 0 134 152 1 2
NOX4 CRH 0 0 307 307 1 1
NOX4 CABP2 0 0 0 210 1 1
NOX4 MT-ND1 0 0 83 223 1 1
NOX4 MAP2K6 0 0 108 284 1 1
NOX4 ATG5 0 0 249 262 1 2
NOX4 FMO3 0 0 95 166 1 1
NOX4 MMP11 0 0 50 150 1 1
NOX4 LTB4R2 0 0 308 307 1 1
NOX4 CABP7 0 0 0 210 1 1
NOX4 KIAA0226 0 0 450 450 1 1
NOX4 SLC22A16 0 0 0 157 1 1
NOX4 PRKAA2 0 0 0 154 1 2
NOX4 GAPDHS 0 0 0 171 1 1
NOX4 SLC22A2 0 0 0 157 1 1
NOX4 SLC7A7 0 0 0 156 1 1
NOX4 DNM1L 0 0 244 243 1 2
NOX4 PTEN 0 0 391 419 1 2
NOX4 FTL 0 0 95 232 1 1
NOX4 TXN2 0 0 408 447 1 1
NOX4 MAPK7 0 0 151 198 1 1
NOX4 STK40 0 0 0 154 1 1
NOX4 VEGFA 0 0 557 557 1 2
NOX4 SREBF1 0 0 306 311 1 1
NOX4 UCP1 0 0 195 195 1 2
NOX4 TSSK6 0 0 0 154 1 1
NOX4 TIMP3 0 0 171 171 1 1
NOX4 MAPK14 0 0 265 448 1 2
NOX4 CFL1 0 0 245 268 1 1
NOX4 LEP 0 0 335 346 1 1
NOX4 NFKBIA 0 0 394 399 1 2
NOX4 KIT 0 0 181 181 1 2
NOX4 ENSG00000273398 0 0 0 170 1 1
NOX4 NFE2L1 0 0 112 303 1 1
NOX4 SUSD5 0 0 65 158 1 1
NOX4 WT1 0 0 144 174 1 1
NOX4 LDHA 0 0 181 200 1 2
NOX4 BMP4 0 0 218 218 1 1
NOX4 ELL2 0 0 0 151 1 1
NOX4 ZNF359 0 0 767 767 1 1
NOX4 CCL3 0 0 149 174 1 1
NOX4 ENG 0 0 170 169 1 2
NOX4 G6PD 0 0 335 347 1 1
NOX4 SHC1 0 0 194 319 1 1
NOX4 CLCN3 0 0 241 321 1 1
NOX4 ATM 0 0 263 283 1 2
NOX4 ATP7B 0 0 0 216 1 1
NOX4 PON2 0 0 244 250 1 1
NOX4 AIF1L 0 0 0 210 1 1
NOX4 CYP4F8 0 0 0 325 1 1
NOX4 COL1A1 0 0 329 353 1 2
NOX4 CXCL2 0 0 137 153 1 1
NOX4 NAMPT 0 0 177 177 1 2
NOX4 PTK7 0 0 0 167 1 1
NOX4 SNAI1 0 0 232 231 1 1
NOX4 IL10 0 0 323 335 1 2
NOX4 MATR3 0 0 471 471 1 1
NOX4 PPP3R1 0 0 0 170 1 1
NOX4 GFAP 0 0 171 171 1 2
NOX4 ACTG1 0 0 167 198 1 1
NOX4 ATG7 0 0 193 218 1 2
NOX4 TJP1 0 0 261 261 1 1
NOX4 SELE 0 0 321 439 1 1
NOX4 TGFBR2 0 0 193 272 1 1
NOX4 CEBPB 0 0 181 181 1 2
NOX4 DHFR 0 0 172 171 1 1
NOX4 TXNRD1 0 0 370 435 1 1
NOX4 PDIA4 0 0 0 283 1 1
NOX4 RIPK1 0 0 134 173 1 2
NOX4 HDAC1 0 0 161 179 1 2
NOX4 CYP26C1 0 0 0 157 1 1
NOX4 EFCAB9 0 0 0 210 1 1
NOX4 TXNRD2 0 0 299 326 1 1
NOX4 ERO1LB 0 0 193 204 1 1
NOX4 MRC1 0 0 141 163 1 1
NOX4 GSK3B 0 0 150 326 1 2
NOX4 SLC11A1 0 0 0 234 1 1
NOX4 PDE1A 0 0 123 236 1 1
NOX4 GPX8 0 0 171 511 1 1
NOX4 MPC2 0 0 81 332 1 1
NOX4 ADM 0 0 161 161 1 2
NOX4 FABP4 0 0 151 150 1 1
NOX4 SOCS2 0 0 63 163 1 1
NOX4 CALM2 0 0 0 243 1 1
NOX4 PTPN12 0 0 143 173 1 1
NOX4 CDKN2A 0 0 253 252 1 2
NOX4 KLF2 0 0 193 216 1 1
NOX4 NRROS 0 0 173 194 1 1
NOX4 CHUK 0 0 234 282 1 1
NOX4 CUL3 0 0 194 212 1 2
NOX4 WNT2 0 0 63 161 1 1
NOX4 IL13 0 0 235 235 1 2
NOX4 REN 0 0 636 667 1 1
NOX4 STK17B 0 0 0 150 1 1
NOX4 RASGRF1 0 0 67 164 1 1
NOX4 GPER1 0 0 166 165 1 2
NOX4 KIF2A 0 0 60 160 1 1
NOX4 ALOX5 0 0 247 246 1 1
NOX4 ACE 0 0 508 541 1 1
NOX4 CYP46A1 0 0 0 157 1 1
NOX4 SLC7A6 0 0 0 156 1 1
NOX4 PPIA 0 0 166 165 1 1
NOX4 DPEP1 0 0 181 198 1 1
NOX4 TRPC4 0 0 95 163 1 1
NOX4 PTS 0 0 422 422 1 1
NOX4 ENSG00000268643 0 0 0 157 1 1
NOX4 CYBB 0 800 914 887 1 2
NOX4 MMP14 0 0 123 151 1 1
NOX4 PLA2G6 0 0 81 181 1 1
NOX4 ARHGAP18 0 0 90 330 1 1
NOX4 HEPHL1 0 0 0 323 1 1
NOX4 HSPA1B 0 0 0 185 1 1
NOX4 NLRP3 0 0 457 457 1 2
NOX4 REL 0 0 141 160 1 2
NOX4 PLD2 0 0 120 154 1 1
NOX4 CYP26B1 0 0 0 157 1 1
NOX4 TRIB3 0 0 85 193 1 2
NOX4 TRPM2 0 0 223 223 1 2
NOX4 CXCL1 0 0 143 159 1 2
NOX4 CPSF1 0 0 0 190 1 1
NOX4 IL33 0 0 134 165 1 2
NOX4 EGLN1 0 0 202 202 1 1
NOX4 CASP3 0 0 561 577 1 2
NOX4 CHP2 0 0 0 170 1 1
NOX4 PDIA6 0 0 51 170 1 1
NOX4 F3 0 0 205 205 1 1
NOX4 NQO1 0 0 459 462 1 2
NOX4 KCNIP1 0 0 0 167 1 1
NOX4 PTGS2 0 0 452 489 1 2
NOX4 CYP26A1 0 0 0 157 1 1
NOX4 CLCN6 0 0 0 190 1 1
NOX4 GALE 0 0 0 151 1 1
NOX4 BGN 0 0 109 210 1 1
NOX4 CPOX 0 0 0 151 1 1
NOX4 PLEKHB1 0 0 0 206 1 1
NOX4 GFM2 0 0 0 211 1 1
NOX4 LPIN1 0 0 71 168 1 2
NOX4 PDIA3 0 0 105 335 1 1
NOX4 STK17A 0 0 0 164 1 1
NOX4 MYH11 0 0 184 183 1 1
NOX4 PGF 0 0 140 187 1 1
NOX4 TLR6 0 0 95 176 1 1
NOX4 IL2 0 0 143 161 1 1
NOX4 OLR1 0 0 457 457 1 2
NOX4 LRP1 0 0 357 357 1 1
NOX4 COX4I2 0 0 127 162 1 1
NOX4 BECN1 0 0 303 303 1 2
NOX4 FRRS1L 0 0 0 159 1 1
NOX4 TMX4 0 0 113 264 1 1
NOX4 MAOB 0 0 167 167 1 1
NOX4 THBS1 0 0 261 261 1 1
NOX4 SMARCD3 0 0 0 161 1 1
NOX4 CYP11A1 0 0 0 152 1 1
NOX4 LRRK2 0 0 60 150 1 2
NOX4 SLC22A9 0 0 0 157 1 1
NOX4 NCALD 0 0 0 167 1 1
NOX4 CYP27C1 0 0 0 171 1 1
NOX4 MET 0 0 119 182 1 2
NOX4 PHB 0 0 171 185 1 1
NOX4 MAPK11 0 0 47 175 1 1
NOX4 FGF23 0 0 107 243 1 1
NOX4 DUSP1 0 0 315 341 1 1
NOX4 SLC5A2 0 0 294 323 1 1
NOX4 PIM3 0 0 0 154 1 1
NOX4 CERS6 0 0 0 212 1 1
NOX4 TLR2 0 0 294 307 1 2
NOX4 SLC25A28 0 0 0 200 1 1
NOX4 FTH1 0 0 150 239 1 1
NOX4 SGCA 0 0 56 161 1 1
NOX4 HSPA5 0 0 340 373 1 2
NOX4 TSSK4 0 0 0 154 1 1
NOX4 SOD2 0 0 595 640 1 2
NOX4 CYP2A13 0 0 0 212 1 1
NOX4 GPX2 0 0 322 506 1 1
NOX4 ADRBK1 0 0 150 171 1 1
NOX4 ITGB2 0 0 108 219 1 1
NOX4 CNGA3 0 0 0 163 1 1
NOX4 EPAS1 0 0 150 284 1 2
NOX4 FOXO1 0 0 324 336 1 2
NOX4 KRAS 0 0 193 283 1 2
NOX4 TGFB1I1 0 0 277 293 1 1
NOX4 MATK 0 0 110 151 1 1
NOX4 FOS 0 0 261 311 1 2
NOX4 SV2A 0 0 0 157 1 1
NOX4 MSTN 0 0 193 193 1 1
NOX4 PTPN11 104 0 246 295 1 1
NOX4 DDAH1 0 0 257 273 1 1
NOX4 AQP4 0 0 107 153 1 1
NOX4 GAB1 0 0 0 189 1 1
NOX4 STAT5A 0 900 158 912 1 1
NOX4 PON1 0 0 202 213 1 1
NOX4 RYR2 0 0 260 336 1 1
NOX4 HSPA1L 0 0 0 179 1 1
NOX4 ARHGEF19 0 0 57 160 1 1
NOX4 MAPK4 0 0 74 198 1 1
NOX4 LONP1 0 0 108 205 1 1
NOX4 SLC22A4 0 0 0 157 1 1
NOX4 SDHB 0 0 145 234 1 1
NOX4 ACO2 0 0 182 211 1 1
NOX4 NFE2 0 0 161 185 1 1
NOX4 CALB2 0 0 0 210 1 1
NOX4 HAVCR1 0 0 302 317 1 1
NOX4 CCL5 0 0 234 234 1 2
NOX4 CREB1 0 0 268 268 1 2
NOX4 STAG2 0 0 0 163 1 1
NOX4 NIT1 0 0 103 156 1 1
NOX4 IFNG 0 0 247 279 1 2
NOX4 NOX3 0 540 951 727 1 1
NOX4 APOA4 0 0 0 214 1 1
NOX4 TAGLN 0 0 296 296 1 1
NOX4 TRPC1 0 0 139 169 1 1
NOX4 FBXO32 0 0 175 175 1 2
NOX4 CYP4X1 0 0 0 157 1 1
NOX4 HSD11B2 0 0 181 235 1 1
NOX4 ANXA5 0 0 321 351 1 2
NOX4 CS 0 0 218 237 1 1
NOX4 NPPA 0 0 234 281 1 1
NOX4 FGF21 0 0 142 201 1 2
NOX4 PRDX6 0 0 170 298 1 1
NOX4 IQGAP1 0 0 138 172 1 1
NOX4 EPO 0 0 282 282 1 2
NOX4 NCS1 0 0 0 167 1 1
NOX4 SIRT2 0 0 274 280 1 2
NOX4 CYP4F3 0 0 0 325 1 1
NOX4 PRDX5 0 0 257 266 1 1
NOX4 RANBP2 0 0 0 153 1 1
NOX4 SLC22A24 0 0 0 157 1 1
NOX4 MMP20 0 0 0 197 1 1
NOX4 TLR10 0 0 73 154 1 1
NOX4 TPO 0 0 90 152 1 1
NOX4 SLC31A2 0 0 0 267 1 1
NOX4 GSTM3 0 0 112 161 1 1
NOX4 RELA 0 0 181 189 1 2
NOX4 BCL2L1 0 0 299 304 1 2
NOX4 KCNIP4 0 0 0 167 1 1
NOX4 EVPL 0 0 63 406 1 1
NOX4 SLC5A4 0 0 293 305 1 1
NOX4 CYP1A1 0 0 164 284 1 2
NOX4 HDGF 0 0 305 305 1 1
NOX4 GAPDH 0 0 594 598 1 2
NOX4 SMAD2 0 0 635 635 1 2
NOX4 TLR4 486 0 989 994 1 2
NOX4 ZSCAN21 0 0 764 764 1 1
NOX4 SLC22A13 0 0 0 157 1 1
NOX4 NNT 0 0 149 189 1 1
NOX4 ABL1 0 0 205 241 1 1
NOX4 NOS2 0 0 341 372 1 2
NOX4 CX3CL1 0 0 155 154 1 1
NOX4 MAP2K7 0 0 245 258 1 1
NOX4 TSSK3 0 0 0 154 1 1
NOX4 POTEE 0 0 0 153 1 1
NOX4 APOA1 0 0 150 169 1 1
NOX4 SLC22A23 0 0 0 157 1 1
NOX4 RAP1A 0 0 204 237 1 1
NOX4 SP1 0 0 184 183 1 2
NOX4 IL1B 0 0 561 561 1 2
NOX4 PRKCB 0 0 286 286 1 2
NOX4 CYP4F2 0 0 0 325 1 1
NOX4 POSTN 0 0 203 277 1 1
NOX4 EDN1 0 0 556 570 1 1
NOX4 HIF1A 0 0 615 618 1 2
NOX4 CYP27B1 0 0 46 157 1 1
NOX4 SLC22A8 0 0 183 299 1 1
NOX4 KCNIP2 0 0 0 167 1 1
NOX4 PYGL 0 0 57 219 1 1
NOX4 SIRT5 0 0 285 284 1 1
NOX4 NOXO1 0 540 758 895 1 1
NOX4 ARF3 0 0 210 233 1 1
NOX4 CXCL8 0 0 401 400 1 2
NOX4 SLC22A25 0 0 0 157 1 1
NOX4 APP 0 0 193 229 1 2
NOX4 MFN2 0 0 241 240 1 2
NOX4 EGR1 0 0 241 240 1 2
NOX4 TRPV1 0 0 216 233 1 2
NOX4 CTNNB1 0 0 339 353 1 2
NOX4 HRAS 0 0 264 338 1 2
NOX4 CDK2 0 0 123 163 1 2
NOX4 COQ9 0 0 113 178 1 1
NOX4 CYP4B1 0 0 0 424 1 1
NOX4 PLA2G4A 0 0 167 192 1 1
NOX4 EFCAB3 0 0 0 210 1 1
NOX4 PASK 0 0 0 197 1 1
NOX4 MMP1 0 0 241 269 1 1
NOX4 PTPN13 0 0 0 189 1 1
NOX4 MYL5 0 0 90 210 1 1
NOX4 NOTCH1 0 0 247 246 1 2
NOX4 PTGS1 0 0 150 208 1 1
NOX4 TRAF4 0 0 147 163 1 1
NOX4 RRAS 0 0 81 208 1 1
NOX4 GUCA1C 0 0 0 167 1 1
NOX4 CXCR4 0 0 193 193 1 2
NOX4 SMOX 0 0 150 221 1 1
NOX4 TIMP4 0 0 162 161 1 1
NOX4 POTEF 0 0 125 227 1 1
NOX4 CALM1 0 0 0 271 1 1
NOX4 MTOR 0 0 370 377 1 2
NOX4 TRIB2 0 0 0 154 1 1
NOX4 EPHX2 0 0 181 249 1 1
NOX4 LRTM2 0 0 90 175 1 1
NOX4 IL6 0 0 558 573 1 2
NOX4 UCP2 0 0 400 407 1 2
NOX4 MPO 0 0 418 457 1 2
NOX4 PRKG1 0 0 212 239 1 1
NOX4 CHP1 0 0 0 170 1 1
NOX4 TNFRSF1A 0 0 210 227 1 1
NOX4 MYL6B 0 0 94 213 1 1
NOX4 CYP4A11 0 0 0 298 1 1
NOX4 NPHS1 0 0 393 409 1 1
NOX4 CYP2F1 0 0 0 394 1 1
NOX4 KCNMA1 0 0 120 210 1 1
NOX4 OCLN 0 0 205 205 1 1
NOX4 KCNA5 0 0 232 233 1 1
NOX4 STAT1 0 0 216 222 1 2
NOX4 P4HTM 0 0 151 150 1 1
NOX4 CYP2C18 0 0 81 281 1 1
NOX4 AQP8 0 0 150 195 1 1
NOX4 CYP4A22 0 0 0 298 1 1
NOX4 FLNB 0 0 55 151 1 1
NOX4 EFCAB6 0 0 0 210 1 1
NOX4 MDM2 0 0 163 163 1 2
NOX4 LCN2 0 0 171 177 1 1
NOX4 TP53 0 0 469 478 1 2
NOX4 ALOX15 0 0 170 169 1 1
NOX4 MAOA 0 0 150 173 1 1
NOX4 TGM2 0 0 150 197 1 2
NOX4 EGFR 0 0 370 390 1 2
NOX4 CDK4 0 0 162 172 1 2
NOX4 MYD88 0 0 267 292 1 2
NOX4 MYL10 0 0 93 213 1 1
NOX4 LAMP1 0 0 113 157 1 2
NOX4 SLC2A1 0 0 277 283 1 2
NOX4 DUOXA2 0 0 520 689 1 1
NOX4 SLC22A6 0 0 69 200 1 1
NOX4 OCM 0 0 0 210 1 1
NOX4 EDN3 0 0 53 152 1 1
NOX4 ZNF19 0 0 735 735 1 1
NOX4 IRAK1 0 0 227 269 1 1
NOX4 SLC2A2 0 0 111 184 1 1
NOX4 LMNA 0 0 170 171 1 2
NOX4 ZSCAN22 0 0 95 162 1 1
NOX4 MCAT 0 0 234 238 1 1
NOX4 EDA 0 0 142 209 1 1
NOX4 MAP3K7 0 0 183 221 1 2
NOX4 HDAC2 0 0 171 204 1 1
NOX4 DDIT3 0 0 321 333 1 2
NOX4 SLC7A5 0 0 0 168 1 1
NOX4 MYL6 0 0 77 199 1 1
NOX4 CDH2 0 0 172 171 1 1
NOX4 APAF1 0 0 138 170 1 2
NOX4 JAK2 0 0 289 321 1 2
NOX4 PPARD 0 0 70 152 1 1
NOX4 SLC22A15 0 0 0 157 1 1
NOX4 MELK 0 0 0 154 1 1
NOX4 TNNC1 0 0 0 210 1 1
NOX4 CALM3 0 0 0 243 1 1
NOX4 GSTK1 0 0 170 169 1 1
NOX4 CYBA 0 800 989 998 1 1
NOX4 MMP15 0 0 0 199 1 1
NOX4 RHPN1 0 0 0 303 1 1
NOX4 MYH6 0 0 243 242 1 1
NOX4 MUC5AC 0 0 181 181 1 1
NOX4 SLC22A3 0 0 0 157 1 1
NOX4 ANKH 0 0 0 225 1 1
NOX4 GCLM 0 0 325 385 1 1
NOX4 ZNF3 0 0 764 764 1 1
NOX4 ERN1 0 0 340 384 1 2
NOX4 EFCAB2 0 0 0 210 1 1
NOX4 MGST2 0 0 161 348 1 1
NOX4 NCDN 0 0 48 253 1 1
NOX4 STAT3 0 0 392 400 1 2
NOX4 RHBDL3 0 0 0 266 1 1
NOX4 CPT2 0 0 166 204 1 1
NOX4 HBEGF 0 0 327 327 1 1
NOX4 DDAH2 0 0 256 256 1 1
NOX4 DHRS7 0 0 60 158 1 1
NOX4 SVOP 0 0 0 176 1 1
NOX4 DUOXA1 0 0 517 687 1 1
NOX4 IL18 0 0 310 319 1 2
NOX4 PPP5C 0 0 466 471 1 1
NOX4 PPIG 0 0 159 158 1 1
NOX4 APEX1 0 0 218 218 1 1
NOX4 PDK1 0 0 158 191 1 2
NOX4 MYC 0 0 298 298 1 2
NOX4 PPARGC1A 0 0 464 463 1 2
NOX4 CIB3 0 0 0 167 1 1
NOX4 IGF1R 0 0 175 224 1 2
NOX4 SDHC 0 0 180 179 1 1
NOX4 COL11A1 0 0 70 182 1 1
NOX4 GNAQ 0 0 181 198 1 1
NOX4 MSRA 0 0 134 165 1 1
NOX4 FKBP1B 0 0 66 160 1 1
NOX4 MEFV 0 0 167 173 1 1
NOX4 G6PC 0 0 142 176 1 1
NOX4 PIM1 0 0 0 154 1 1
NOX4 TRAF2 0 0 134 157 1 2
NOX4 P4HB 0 0 791 802 1 2
NOX4 GPX7 0 0 248 546 1 1
NOX4 CIB2 0 0 0 167 1 1
NOX4 MMP17 0 0 0 199 1 1
NOX4 SLC22A10 0 0 0 157 1 1
NOX4 CETN3 0 0 0 167 1 1
NOX4 ALOX12 0 0 183 183 1 1
NOX4 TMEM45A 0 0 0 162 1 1
NOX4 TTN 0 0 101 186 1 1
NOX4 SMAD4 0 0 323 337 1 2
NOX4 ACTA1 0 0 180 248 1 1
NOX4 SYNPO 0 0 166 165 1 1
NOX4 PARK7 0 0 203 220 1 2
NOX4 NOXA1 0 540 754 902 1 1
NOX4 AKT2 0 0 170 207 1 2
NOX4 ICA1 0 0 68 228 1 1
NOX4 MYL9 0 0 99 218 1 1
NOX4 NFE2L2 0 0 563 575 1 2
NOX4 TLR1 0 0 120 174 1 1
NOX4 MAP2K5 0 0 93 233 1 1
NOX4 VASP 0 0 202 207 1 1
NOX4 MAP2K1 0 0 222 236 1 1
NOX4 PPIF 0 0 232 231 1 1
NOX4 OPA1 0 0 141 200 1 2
NOX4 PDGFB 0 0 270 306 1 2
NOX4 CYB5A 0 0 96 161 1 1
NOX4 ZKSCAN1 0 0 787 787 1 1
NOX4 STK11 0 0 159 258 1 2
NOX4 PXN 0 0 699 706 1 1
NOX4 HIST2H3PS2 0 0 209 223 1 1
NOX4 SPATA21 0 0 0 210 1 1
NOX4 RHPN2 0 0 44 531 1 1
NOX4 SESN2 0 0 204 204 1 2
NOX4 LPO 0 0 193 248 1 1
NOX4 TNS1 0 0 142 169 1 1
NOX4 VR1 0 0 216 233 1 1
NOX4 GPX4 0 0 370 541 1 2
NOX4 SSH1 0 0 166 198 1 1
NOX4 CALML4 0 0 0 210 1 1
NOX4 FKBP1A 0 0 143 229 1 2
NOX4 CYP2B6 0 0 42 213 1 1
NOX4 COL4A1 0 0 150 196 1 1
NOX4 P2RX7 0 0 108 182 1 2
NOX4 CTGF 0 0 518 531 1 1
NOX4 GCLC 0 0 391 413 1 1
NOX4 ANAPC1 0 0 47 370 1 1
NOX4 ARG1 0 0 194 194 1 2
NOX4 MAPK8 0 0 325 326 1 2
NOX4 PTK2 0 0 181 205 1 2
NOX4 PTGIS 0 0 212 274 1 1
NOX4 MYLPF 0 0 100 219 1 1
NOX4 ADIPOQ 0 0 394 397 1 2
NOX4 PLD1 0 0 119 179 1 2
NOX4 PKDCC 0 0 0 154 1 1
NOX4 PPP3R2 0 0 0 170 1 1
NOX4 ZNF33B 0 0 193 193 1 1
NOX4 SLC22A1 0 0 47 163 1 1
NOX4 ZNF7 0 0 655 655 1 1
NOX4 OGG1 0 0 228 231 1 1
NOX4 CYCS 0 0 519 519 1 2
NOX4 MYL12A 0 0 86 206 1 1
NOX4 SESN3 0 0 139 157 1 1
NOX4 TRAF6 0 0 264 265 1 2
NOX4 NANOG 0 0 135 156 1 2
NOX4 CASP9 0 0 310 309 1 2
NOX4 ITPR1 0 0 173 185 1 2
NOX4 CYP4F11 0 0 0 325 1 1
NOX4 FASN 0 0 134 193 1 2
NOX4 ETS1 0 0 183 183 1 1
NOX4 CYP27A1 0 0 0 152 1 1
NOX4 BMP2 0 0 171 171 1 1
NOX4 EGF 0 0 390 390 1 2
NOX4 HNF1A 0 0 123 154 1 1
NOX4 AKR1B1 0 0 266 266 1 1
NOX4 ATP5A1 0 0 128 166 1 1
NOX4 IL17A 0 0 224 224 1 2
NOX4 ZNF32 0 0 162 161 1 1
NOX4 TYR 0 0 90 157 1 2
NOX4 POTEJ 0 0 0 153 1 1
NOX4 TMX1 0 0 134 253 1 1
NOX4 DICER1 0 0 183 183 1 1
NOX4 ATP6AP2 0 0 361 361 1 1
NOX4 C1QTNF2 0 0 295 295 1 1
NOX4 CYP1B1 0 0 107 218 1 1
NOX4 CFD 0 0 247 246 1 1
NOX4 GATA4 0 0 233 277 1 2
NOX4 HSPA4 0 0 238 264 1 1
NOX4 ZNF16 0 0 765 765 1 1
NOX4 TEK 0 0 229 228 1 1
NOX4 ACHE 0 0 90 163 1 2
NOX4 TRIB1 0 0 0 154 1 1
NOX4 PPARA 0 0 454 465 1 2
NOX4 HPCAL4 0 0 0 167 1 1
NOX4 CCR2 0 0 211 211 1 2
NOX4 TRPC6 0 0 326 325 1 1
NOX4 HSPB3 0 0 205 205 1 1
NOX4 PDCD4 0 0 112 152 1 2
NOX4 CYP2E1 0 0 323 426 1 2
NOX4 HSP90B1 0 0 454 458 1 1
NOX4 KNG1 0 0 263 263 1 1
NOX4 CCL2 0 0 557 566 1 2
NOX4 ALB 0 0 518 548 1 2
NOX4 CD68 0 0 325 358 1 2
NOX4 CASP8 0 0 181 181 1 2
NOX4 LEPR 0 0 202 208 1 1
NOX4 SLC25A37 0 0 0 200 1 1
NOX4 IL16 0 0 90 182 1 1
NOX4 CALML5 0 0 0 210 1 1
NOX4 SLC22A11 0 0 0 157 1 1
NOX4 CYP4F12 0 0 0 325 1 1
NOX4 ELAVL1 0 0 134 188 1 2
NOX4 LRRC8E 0 0 66 151 1 1
NOX4 ITGB1 0 0 134 176 1 1
NOX4 PVALB 0 0 54 220 1 1
NOX4 FAP 0 0 0 193 1 2
NOX4 GTF2IRD1 0 0 0 343 1 1
NOX4 SLC22A17 0 0 0 157 1 1
NOX4 IL4 0 0 262 262 1 1
NOX4 SCARB1 0 0 134 180 1 1
NOX4 SH3PXD2B 0 0 322 339 1 1
NOX4 SLC12A2 0 0 57 189 1 1
NOX4 PDGFRB 0 0 232 231 1 2
NOX4 GPX5 0 0 180 486 1 1
NOX4 SIRPA 104 0 698 718 1 1
NOX4 EP300 0 0 163 163 1 2
NOX4 ADIPOR1 0 0 202 219 1 1
NOX4 MYLK 0 0 167 173 1 1
NOX4 ROCK1 0 0 204 257 1 2
NOX4 ERO1L 0 0 411 420 1 1
NOX4 RASSF6 0 0 0 213 1 1
NOX4 HVCN1 0 0 218 266 1 1
NOX4 PHACTR1 0 0 70 166 1 1
NOX4 SMAD3 0 0 556 558 1 2
NOX4 ANXA8 0 0 150 182 1 1
NOX4 CTH 0 0 359 412 1 1
NOX4 CP 0 0 124 382 1 1
NOX4 SIRT6 0 0 314 313 1 2
NOX4 USP32 0 0 0 167 1 1
NOX4 OCM2 0 0 0 210 1 1
NOX4 AGER 0 800 282 850 1 2
NOX4 CERS2 0 0 0 212 1 1
NOX4 SLC22A12 0 0 134 257 1 1
NOX4 KCNIP3 0 0 0 167 1 1
NOX4 ACTC1 0 0 125 260 1 1
NOX4 EFCAB1 0 0 0 167 1 1
NOX4 CDH1 0 0 249 248 1 2
NOX4 RAP2B 0 0 218 250 1 1
NOX4 NCF4 0 540 754 885 1 1
NOX4 CALML3 0 0 0 210 1 1
NOX4 CABP4 0 0 0 210 1 1
NOX4 SH3PXD2A 0 0 424 433 1 1
NOX4 RYR1 0 0 492 539 1 2
NOX4 TTC7B 0 0 203 221 1 1
NOX4 PRKCZ 0 0 270 303 1 1
NOX4 PLG 0 0 284 299 1 1
NOX4 MAF 0 0 180 179 1 1
NOX4 VPS54 0 0 0 161 1 1
NOX4 MAP3K11 0 0 134 200 1 1
NOX4 NR3C2 0 0 325 343 1 1
NOX4 DPP4 0 0 282 307 1 1
NOX4 LOXL2 0 0 167 167 1 1
NOX4 BCHE 0 0 123 198 1 1
NOX4 ABCA1 0 0 211 215 1 2
NOX4 ROCK2 0 0 96 265 1 1
NOX4 CABP5 0 0 0 210 1 1
NOX4 CALML6 0 0 0 210 1 1
NOX4 AQP2 0 0 134 179 1 1
NOX4 IL1A 0 0 172 190 1 1
NOX4 ACVR2B 0 0 75 154 1 1
NOX4 H2AFX 0 0 218 218 1 1
NOX4 ATP2A1 0 0 88 172 1 1
NOX4 NIM1K 0 0 0 154 1 1
NOX4 HUNK 0 0 0 154 1 1
NOX4 CYP2R1 0 0 0 170 1 1
NOX4 PTPRC 0 0 208 208 1 1
NOX4 CYP2U1 0 0 0 170 1 1
NOX4 ESR2 0 0 134 152 1 1
NOX4 SIRT7 0 0 283 282 1 2
NOX4 ZEB1 0 0 140 164 1 2
NOX4 ICAM1 0 0 507 526 1 2
NOX4 SPR 0 0 67 161 1 1
NOX4 NKRF 0 0 170 169 1 1
NOX4 CDKN1A 0 0 213 213 1 2
NOX4 SPP1 0 0 365 365 1 2
NOX4 ERP44 0 0 112 204 1 1
NOX4 GSR 0 0 470 491 1 1
NOX4 HSPA8 0 0 95 219 1 2
NOX4 PARP1 0 0 212 218 1 2
NOX4 RHOA 0 0 423 449 1 2
NOX4 ASXL1 0 0 0 190 1 1
NOX4 MYL1 0 0 86 206 1 1
NOX4 TLR5 0 0 562 589 1 1
NOX4 PLA2G1B 0 0 228 227 1 1
NOX4 BAX 0 0 170 176 1 2
NOX4 TIMP1 0 0 366 366 1 1
NOX4 CXCL12 0 0 285 285 1 2
NOX4 CLDN5 0 0 167 167 1 1
NOX4 ATG13 0 0 55 166 1 2
NOX4 ACP1 0 0 334 351 1 1
NOX4 SELP 0 0 246 322 1 1
NOX4 INS 0 0 623 623 1 2
NOX4 ACTB 0 0 601 647 1 2
NOX4 RFK 0 0 95 161 1 1
NOX4 GRAP2 0 0 75 217 1 1
NOX4 ARHGDIA 0 0 113 155 1 1
NOX4 CTTN 0 0 144 165 1 1
NOX4 STUB1 0 0 125 254 1 2
NOX4 GLP1R 0 0 228 276 1 1
NOX4 DNMT1 0 0 186 186 1 2
NOX4 TTF2 0 0 0 223 1 1
NOX4 KEAP1 0 0 556 566 1 2
NOX4 MMP9 0 0 469 489 1 2
NOX4 B2M 0 0 157 163 1 1
NOX4 MAPK3 0 0 519 546 1 2
NOX4 KLF15 0 0 82 167 1 1
NOX4 SLC30A9 0 0 66 170 1 1
NOX4 THY1 0 0 165 165 1 1
NOX4 ABCG1 0 0 183 205 1 2
NOX4 ANGPT1 0 0 241 257 1 1
NOX4 SIRT3 0 0 400 413 1 2
NOX4 PROM1 0 0 134 171 1 2
NOX4 MYL12B 0 0 96 215 1 1
NOX4 PCK2 0 0 387 400 1 1
NOX4 CRYZ 0 0 210 227 1 1
NOX4 SLC11A2 0 0 61 250 1 1
NOX4 PDGFD 0 0 63 163 1 1
NOX4 BNIP3 0 0 218 261 1 2
NOX4 KHSRP 0 0 0 216 1 1
NOX4 PDIA2 0 0 0 173 1 1
NOX4 HSP90AA1 0 0 311 316 1 2
NOX4 HDAC4 0 0 279 279 1 2
NOX4 HPGDS 0 0 291 290 1 1
NOX4 SLC9A3 0 0 144 192 1 1
NOX4 CEBPA 0 0 181 181 1 1
NOX4 ATF2 0 0 90 152 1 1
NOX4 COX4I1 0 0 234 249 1 1
NOX4 CRP 0 0 283 314 1 2
NOX4 KL 0 0 213 213 1 2
NOX4 KCNK3 0 0 831 831 1 1
NOX4 ENSG00000173366 0 0 142 158 1 1
NOX4 CYP19A1 0 0 43 159 1 2
NOX4 COX17 0 0 0 208 1 1
NOX4 FMO4 0 0 146 213 1 1
NOX4 CALB1 0 0 0 210 1 1
NOX4 NRF1 0 0 189 189 1 2
NOX4 CDH17 0 0 167 167 1 1
NOX4 NPPB 0 0 195 195 1 1
NOX4 BCL2L11 0 0 234 234 1 2
NOX4 FRRS1 0 0 0 159 1 1
NOX4 MYL7 0 0 92 212 1 1
NOX4 MT1HL1 0 0 87 162 1 1
NOX4 HEPH 0 0 0 323 1 1
NOX4 CNGA1 0 0 0 163 1 1
NOX4 PXDN 0 0 248 311 1 1
NOX4 ITPR3 0 0 181 193 1 1
NOX4 JUN 0 0 503 518 1 2
NOX4 EIF2AK1 0 0 81 221 1 1
NOX4 CYP4Z1 0 0 0 157 1 1
NOX4 NOS1 0 0 460 483 1 1
NOX4 CASP1 0 0 324 323 1 2
NOX4 MPZL1 0 0 0 303 1 1
NOX4 SNCA 0 0 165 165 1 2
NOX4 CIB4 0 0 0 170 1 1
NOX4 CHEK1 0 0 143 205 1 2
NOX4 DNTT 0 0 260 260 1 1
NOX4 MAP2K3 0 0 134 336 1 1
NOX4 DGKQ 0 0 47 195 1 1
NOX4 HPCAL1 0 0 0 167 1 1
NOX4 ULK2 0 0 54 165 1 2
NOX4 POLDIP2 0 0 986 986 1 1
NOX4 CERS5 0 0 0 212 1 1
NOX4 HSPA1A 0 0 112 246 1 1
NOX4 COL18A1 0 0 160 159 1 1
NOX4 AIF1 0 0 235 369 1 2
NOX4 SRF 0 0 294 294 1 1
NOX4 SPSB4 0 0 66 168 1 1
NOX4 CAV1 0 0 431 445 1 2
NOX4 CALR 0 0 326 325 1 1
NOX4 SMAD1 0 0 143 161 1 2
NOX4 CD8A 0 0 157 166 1 1
NOX4 SORD 0 0 124 161 1 1
NOX4 IRS2 0 0 143 164 1 1
NOX4 PUM2 0 0 0 163 1 1
NOX4 MFN1 0 0 189 189 1 2
NOX4 IGFBP3 0 0 181 181 1 2
NOX4 SLC27A6 0 0 442 442 1 1
NOX4 MMP2 0 0 391 390 1 2
NOX4 SLC7A9 0 0 0 156 1 1
NOX4 SEL1L2 0 0 0 161 1 1
NOX4 TBXAS1 0 0 108 160 1 1
NOX4 TFAM 0 0 320 323 1 2
NOX4 CNR2 0 0 86 179 1 1
NOX4 SLC7A10 0 0 0 156 1 1
NOX4 COL3A1 0 0 243 280 1 1
NOX4 ANGPT2 0 0 164 163 1 1
NOX4 VSNL1 0 0 0 167 1 1
NOX4 JAG1 0 0 134 155 1 1
NOX4 LCK 0 0 112 152 1 1
NOX4 CYSLTR1 0 0 113 168 1 1
NOX4 FYN 0 0 278 378 1 1
NOX4 GRB2 0 0 608 608 1 1
NOX4 PRDX1 0 0 390 440 1 1
NOX4 GTPBP4 0 0 171 171 1 1
NOX4 LTA 0 0 0 202 1 1
NOX4 SOD1 0 0 505 601 1 2
NOX4 ARNT 0 0 216 216 1 2
NOX4 TRPC5 0 0 137 202 1 1
NOX4 CETN2 0 0 0 167 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0016174 Molecular Function NAD(P)H oxidase H2O2-forming activity enables IDA
GO:0016174 Molecular Function NAD(P)H oxidase H2O2-forming activity enables IMP
GO:0016174 Molecular Function NAD(P)H oxidase H2O2-forming activity enables TAS
GO:0009055 Molecular Function electron transfer activity enables TAS
GO:0050660 Molecular Function flavin adenine dinucleotide binding enables TAS
GO:0020037 Molecular Function heme binding enables IDA
GO:0020037 Molecular Function heme binding enables TAS
GO:0072341 Molecular Function modified amino acid binding enables IDA
GO:0000166 Molecular Function nucleotide binding enables TAS
GO:0019826 Molecular Function oxygen sensor activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:1990782 Molecular Function protein tyrosine kinase binding enables ISS
GO:0016175 Molecular Function superoxide-generating NAD(P)H oxidase activity enables IBA
GO:0016175 Molecular Function superoxide-generating NAD(P)H oxidase activity enables IDA
GO:0045453 Biological Process bone resorption involved_in IEA
GO:0055007 Biological Process cardiac muscle cell differentiation involved_in IEA
GO:0000902 Biological Process cell morphogenesis involved_in ISS
GO:0071333 Biological Process cellular response to glucose stimulus involved_in IEA
GO:0006952 Biological Process defense response involved_in IBA
GO:0022900 Biological Process electron transport chain involved_in IEA
GO:0010467 Biological Process gene expression involved_in IMP
GO:0003015 Biological Process heart process involved_in IGI
GO:0050667 Biological Process homocysteine metabolic process involved_in IDA
GO:0006954 Biological Process inflammatory response involved_in TAS
GO:0008285 Biological Process negative regulation of cell population proliferation involved_in ISS
GO:2000573 Biological Process positive regulation of DNA biosynthetic process involved_in IEA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IEA
GO:0051897 Biological Process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IEA
GO:0061098 Biological Process positive regulation of protein tyrosine kinase activity involved_in ISS
GO:1903409 Biological Process reactive oxygen species biosynthetic process involved_in NAS
GO:0042554 Biological Process superoxide anion generation involved_in IBA
GO:0042554 Biological Process superoxide anion generation involved_in ISS
GO:0006801 Biological Process superoxide metabolic process involved_in IDA
GO:0043020 Cellular Component NADPH oxidase complex part_of IBA
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IDA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in TAS
GO:0005925 Cellular Component focal adhesion located_in IEA
GO:0016020 Cellular Component membrane located_in TAS
GO:0005739 Cellular Component mitochondrion located_in ISS
GO:0005730 Cellular Component nucleolus located_in IEA
GO:0005634 Cellular Component nucleus located_in IDA
GO:0005634 Cellular Component nucleus located_in ISS
GO:0097038 Cellular Component perinuclear endoplasmic reticulum located_in ISS
GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IDA
GO:0048471 Cellular Component perinuclear region of cytoplasm located_in ISS
GO:0005886 Cellular Component plasma membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in TAS
Pathways
Name DB ID
Disease Reactome R-HSA-1643685
Cellular responses to stress Reactome R-HSA-2262752
Detoxification of Reactive Oxygen Species Reactome R-HSA-3299685
Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
Cellular responses to stimuli Reactome R-HSA-8953897
FLT3 signaling in disease Reactome R-HSA-9682385
STAT5 activation downstream of FLT3 ITD mutants Reactome R-HSA-9702518
Signaling by FLT3 fusion proteins Reactome R-HSA-9703465
Signaling by FLT3 ITD and TKD mutants Reactome R-HSA-9703648
Cellular response to chemical stress Reactome R-HSA-9711123
Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
Angiotensin II receptor type 1 pathway (WP5036) WikiPathways WP5036_r119016
Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
Oxidative stress response (WP408) WikiPathways WP408_r116900
Burn wound healing (WP5055) WikiPathways WP5055_r122621
Ferroptosis (WP4313) WikiPathways WP4313_r123507
Spinal cord injury (WP2431) WikiPathways WP2431_r120812
VEGFA-VEGFR2 signaling pathway (WP3888) WikiPathways WP3888_r116782
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_120406 2 miscRNA transcript variant 7 NC_000011 Reference
NM_001143837 2 mRNA transcript variant 3 NC_000011 Reference
NM_001300995 1 mRNA transcript variant 8 NC_000011 Reference
NM_001291926 2 mRNA transcript variant 4 NC_000011 Reference
NM_001143836 3 mRNA transcript variant NOX4B NC_000011 Reference
NM_016931 5 mRNA transcript variant 1 NC_000011 Reference
NM_001291927 1 mRNA transcript variant 5 NC_000011 Reference
NM_001291929 2 mRNA transcript variant 6 NC_000011 Reference
XM_017017843 3 mRNA transcript variant X1 NC_000011 Reference