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TBC1D7

TBC1 domain family member 7
General Information
Name TBC1 domain family member 7
Alias
  • TBC1 domain family member 7
  • TBC domain family 7
  • TS complex subunit 3
  • Tre2-Bub2-Cdc16 Domain Family Member 7
  • cell migration-inducing protein 23
Gene_family TSC complex
organism Homo sapiens
entrez_id 51256
location 6p24.1
transcript_count 7
exon_count 8
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the TBC-domain containing protein family. The encoded protein functions as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation. Mutations in this gene have been associated with autosomal recessive megalencephaly. Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between this locus and downstream LOC100130357. [provided by RefSeq, Jan 2016]
    Stringdb TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is un [...]
    nextProt Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TBC1D7 BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID CCNF GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID ATG9A GeneID BioGRID Proximity Label-MS
TBC1D7 BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TBC1D7 BioGRID YWHAG GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID YWHAE GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID YWHAB GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID MMS19 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID KIF27 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID TSC2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TBC1D7 BioGRID TSC1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TBC1D7 BioGRID FASN GeneID BioGRID Negative Genetic
TBC1D7 BioGRID SH3GLB2 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID TRIM62 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID HOOK1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID MMADHC GeneID BioGRID Two-hybrid
TBC1D7 BioGRID LDOC1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID LZTS1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID KEAP1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID TRAF4 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID BAG4 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID PICK1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID SSNA1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID BLZF1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID XPA GeneID BioGRID Two-hybrid
TBC1D7 BioGRID KRT35 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID KRT19 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID ALOX5 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID INCA1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID MIPOL1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID FBXW11 GeneID BioGRID Affinity Capture-Western
TBC1D7 BioGRID PHLPP1 GeneID BioGRID Affinity Capture-Western
TBC1D7 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TBC1D7 BioGRID PIH1D1 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID LNX2 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID TNIP2 GeneID BioGRID Affinity Capture-RNA
TBC1D7 BioGRID DNAAF10 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID RRAGC GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID LAMTOR1 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID CPVL GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID TBC1D7 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID RUVBL2 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID RRAGA GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID URI1 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID Kif2c GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID Tsc1 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID Ezr GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID MZT1 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID KIF2C GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
TBC1D7 BioGRID LZTS2 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID RPGRIP1 GeneID BioGRID Two-hybrid
TBC1D7 BioGRID APP GeneID BioGRID Reconstituted Complex
TBC1D7 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TBC1D7 BioGRID GABARAPL1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TBC1D7 BioGRID NEDD4L GeneID BioGRID Reconstituted Complex
TBC1D7 BioGRID NEDD4 GeneID BioGRID Reconstituted Complex
TBC1D7 BioGRID BECN1 GeneID BioGRID Affinity Capture-MS
TBC1D7 BioGRID IKBKG GeneID BioGRID Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
TBC1D7 MIOS 0 0 455 455 1 1
TBC1D7 GFOD1 0 0 154 592 1 1
TBC1D7 RAP1GAP 0 0 218 218 1 1
TBC1D7 IDH2 0 0 0 183 1 1
TBC1D7 ENSG00000278299 0 0 325 342 1 1
TBC1D7 SUGCT 0 0 264 264 1 1
TBC1D7 TTI1 0 0 374 410 1 1
TBC1D7 RPL38 0 0 81 175 1 1
TBC1D7 BMP10 0 0 90 152 1 1
TBC1D7 SLC3A2 0 0 193 193 1 1
TBC1D7 TBC1D2 0 0 194 378 1 1
TBC1D7 TBC1D22A 0 0 171 397 1 1
TBC1D7 TBC1D8 0 0 339 483 1 1
TBC1D7 GMNN 0 0 0 180 1 1
TBC1D7 RABEP1 0 0 140 190 1 1
TBC1D7 PTTG1 0 0 0 154 1 1
TBC1D7 HOOK1 494 0 0 493 1 1
TBC1D7 TXN2 0 0 0 197 1 1
TBC1D7 PTEN 0 0 282 282 1 2
TBC1D7 SGSM1 0 0 295 518 1 1
TBC1D7 BBS10 0 0 96 152 1 1
TBC1D7 ZCCHC3 0 0 212 342 1 1
TBC1D7 AGPS 0 0 0 260 1 1
TBC1D7 EIF4A1 0 0 210 210 1 1
TBC1D7 KLHL14 0 0 155 321 1 1
TBC1D7 RRAGB 0 0 544 544 1 1
TBC1D7 SERTAD3 0 0 180 181 1 1
TBC1D7 TELO2 0 0 145 176 1 1
TBC1D7 PRKAA2 0 800 43 805 1 2
TBC1D7 TBCK 0 0 384 384 1 1
TBC1D7 LDHA 0 0 74 170 1 2
TBC1D7 PHACTR1 0 0 108 585 1 1
TBC1D7 FGB 0 0 57 548 1 1
TBC1D7 RABGAP1L 0 0 125 364 1 1
TBC1D7 MADD 0 0 147 238 1 1
TBC1D7 TBC1D10A 0 0 160 305 1 1
TBC1D7 SREBF1 0 0 187 187 1 1
TBC1D7 IGFBP1 0 0 0 152 1 1
TBC1D7 SIRT1 0 0 74 171 1 2
TBC1D7 VCAN 0 0 0 187 1 1
TBC1D7 TBC1D15 0 0 184 309 1 1
TBC1D7 FLCN 0 0 456 456 1 1
TBC1D7 SESN3 0 0 246 245 1 1
TBC1D7 RPS6KA3 0 600 324 718 1 1
TBC1D7 GADD45B 0 0 43 303 1 1
TBC1D7 AAR2 0 0 181 322 1 1
TBC1D7 GNPAT 0 0 0 252 1 1
TBC1D7 LARP1B 0 0 0 190 1 1
TBC1D7 RPTOR 0 0 595 595 1 2
TBC1D7 TBC1D23 0 0 169 169 1 1
TBC1D7 PDCD4 0 0 123 153 1 2
TBC1D7 TBC1D5 0 0 106 308 1 2
TBC1D7 RPAP2 0 0 123 313 1 1
TBC1D7 TBC1D9B 0 0 213 389 1 1
TBC1D7 PCNA 0 0 0 155 1 2
TBC1D7 TYR 0 0 0 181 1 2
TBC1D7 RPL22L1 0 0 49 156 1 1
TBC1D7 DPPA4 0 0 0 152 1 1
TBC1D7 CDC45 0 0 0 181 1 1
TBC1D7 RPS6KB2 0 0 193 203 1 2
TBC1D7 TYRP1 0 0 60 158 1 1
TBC1D7 FKBP1A 0 0 289 297 1 2
TBC1D7 DYRK1A 486 0 0 485 1 1
TBC1D7 AGFG1 0 0 101 346 1 1
TBC1D7 KPTN 0 0 450 454 1 1
TBC1D7 SH3BGRL3 0 0 150 272 1 1
TBC1D7 SESN2 0 0 325 338 1 2
TBC1D7 VPS18 0 0 81 372 1 1
TBC1D7 ATP6V0D2 0 0 0 186 1 1
TBC1D7 RPS6KA1 0 600 426 760 1 1
TBC1D7 ULK1 0 0 230 229 1 2
TBC1D7 PLD1 0 0 134 157 1 2
TBC1D7 TBC1D14 0 0 293 486 1 2
TBC1D7 URI1 270 0 44 294 1 1
TBC1D7 PSMD14 0 0 0 200 1 1
TBC1D7 RALA 0 0 113 180 1 1
TBC1D7 FNIP1 0 0 422 426 1 1
TBC1D7 FUT9 0 0 269 269 1 1
TBC1D7 RUVBL1 0 0 151 150 1 1
TBC1D7 IKBKG 178 0 0 177 1 1
TBC1D7 IFT27 0 0 122 256 1 1
TBC1D7 SKP2 0 0 123 158 1 2
TBC1D7 ARL9 0 0 142 162 1 1
TBC1D7 AKT3 0 800 262 846 1 2
TBC1D7 FOXO1 0 0 182 181 1 2
TBC1D7 KRAS 0 0 59 169 1 2
TBC1D7 RSPH4A 0 0 123 256 1 1
TBC1D7 TSPAN2 0 0 261 261 1 1
TBC1D7 CORO1C 0 0 94 566 1 1
TBC1D7 DHRS7B 0 0 92 384 1 1
TBC1D7 ATP5B 0 0 160 159 1 1
TBC1D7 DNAJC13 0 0 181 181 1 1
TBC1D7 TFE3 0 0 163 163 1 2
TBC1D7 CSRP2 0 0 95 159 1 1
TBC1D7 EIF4A2 0 0 207 207 1 1
TBC1D7 DEPDC5 0 0 470 471 1 1
TBC1D7 MLST8 0 0 560 573 1 1
TBC1D7 TBC1D25 0 0 53 152 1 1
TBC1D7 ME3 0 0 0 256 1 1
TBC1D7 PHACTR4 0 0 0 226 1 1
TBC1D7 TBC1D4 0 0 234 373 1 1
TBC1D7 TBC1D10B 0 0 166 347 1 1
TBC1D7 NPRL3 0 0 455 455 1 1
TBC1D7 SLMO1 0 0 234 409 1 1
TBC1D7 DEPTOR 0 0 557 568 1 2
TBC1D7 RRAGC 270 0 595 691 1 1
TBC1D7 TBC1D2B 0 0 203 419 1 1
TBC1D7 YWHAZ 847 0 402 905 1 1
TBC1D7 RSPH6A 0 0 0 187 1 1
TBC1D7 NDUFA3 0 0 112 173 1 1
TBC1D7 WDR59 0 0 423 427 1 1
TBC1D7 TTLL5 0 0 142 514 1 1
TBC1D7 LAMP2 0 0 264 280 1 2
TBC1D7 TTLL4 0 0 0 202 1 1
TBC1D7 LPIN1 0 0 267 267 1 2
TBC1D7 RRAGD 0 0 556 556 1 1
TBC1D7 TSC1 974 800 970 999 1 2
TBC1D7 MTHFD2 0 0 193 224 1 1
TBC1D7 RABGAP1 0 0 114 356 1 1
TBC1D7 HAO2 0 0 45 261 1 1
TBC1D7 WDR83OS 0 0 286 339 1 1
TBC1D7 PIM3 0 0 91 291 1 1
TBC1D7 TFIP11 0 0 0 260 1 1
TBC1D7 CAD 0 0 167 234 1 2
TBC1D7 CEP104 0 0 112 167 1 1
TBC1D7 TBC1D21 0 0 390 473 1 1
TBC1D7 BECN1 142 0 90 185 1 2
TBC1D7 EIF4EBP2 0 0 195 195 1 1
TBC1D7 AKT1S1 0 0 563 574 1 1
TBC1D7 PEX16 0 0 68 238 1 1
TBC1D7 FGD1 0 0 102 196 1 1
TBC1D7 STXBP1 0 0 69 316 1 1
TBC1D7 EEF2K 0 0 218 239 1 2
TBC1D7 AVPI1 0 0 181 457 1 1
TBC1D7 BNIP3 0 0 96 163 1 2
TBC1D7 MAPK3 0 800 134 819 1 2
TBC1D7 GPR137B 0 0 134 230 1 1
TBC1D7 RPS6KA6 0 600 0 616 1 1
TBC1D7 PHACTR2 0 0 0 302 1 1
TBC1D7 PSMA5 0 0 0 170 1 1
TBC1D7 RNGTT 0 0 113 235 1 1
TBC1D7 ATG13 0 0 243 242 1 2
TBC1D7 INS 0 0 323 323 1 2
TBC1D7 AFP 0 0 0 181 1 2
TBC1D7 CENPN 0 0 0 154 1 1
TBC1D7 TBC1D9 0 0 243 635 1 1
TBC1D7 EIF4B 0 0 254 255 1 1
TBC1D7 DHX29 0 0 0 153 1 1
TBC1D7 TBC1D3D 0 0 324 341 1 1
TBC1D7 RFC4 0 0 0 181 1 1
TBC1D7 NHP2L1 0 0 75 173 1 1
TBC1D7 UQCC2 0 0 74 192 1 1
TBC1D7 TOR1B 0 0 0 153 1 1
TBC1D7 WASF2 0 0 0 156 1 1
TBC1D7 EXOC5 0 0 174 226 1 1
TBC1D7 RNF152 0 0 391 404 1 1
TBC1D7 KIF27 457 0 0 457 1 1
TBC1D7 TFEB 0 0 325 325 1 2
TBC1D7 OCA2 0 0 57 150 1 1
TBC1D7 LAMTOR1 270 0 459 588 1 1
TBC1D7 AHSG 0 0 0 152 1 1
TBC1D7 GABARAPL1 270 0 0 270 1 2
TBC1D7 YWHAH 182 0 0 181 1 1
TBC1D7 TXNRD2 0 0 0 204 1 1
TBC1D7 WDR92 270 0 0 270 1 1
TBC1D7 IQCB1 0 0 95 255 1 1
TBC1D7 RAB35 0 0 122 176 1 1
TBC1D7 HBE1 0 0 0 154 1 1
TBC1D7 ABCD4 0 0 0 163 1 1
TBC1D7 USP6 0 0 759 759 1 1
TBC1D7 TXNRD1 0 0 0 216 1 1
TBC1D7 RAB1A 0 0 194 194 1 1
TBC1D7 ADSS 0 0 70 212 1 1
TBC1D7 RPAP3 0 0 112 226 1 1
TBC1D7 KIAA1731NL 0 0 188 188 1 1
TBC1D7 TBC1D19 0 0 392 456 1 1
TBC1D7 EIF4G1 0 0 218 218 1 2
TBC1D7 MT-ND4L 0 0 48 150 1 1
TBC1D7 TBC1D1 0 0 393 498 1 1
TBC1D7 FXYD6 0 0 125 443 1 1
TBC1D7 GATSL3 0 0 459 470 1 1
TBC1D7 GSK3B 0 800 108 818 1 2
TBC1D7 MTOR 0 0 556 563 1 2
TBC1D7 MAPKAP1 0 0 154 344 1 1
TBC1D7 EVI5L 0 0 0 290 1 1
TBC1D7 GIMAP8 0 0 0 207 1 1
TBC1D7 WDR24 0 0 460 463 1 1
TBC1D7 TRAF4 475 0 0 475 1 1
TBC1D7 CCNO 0 0 116 317 1 1
TBC1D7 TRAPPC8 0 0 0 213 1 1
TBC1D7 MZT1 275 0 0 275 1 1
TBC1D7 GATSL2 0 0 325 339 1 1
TBC1D7 FBXW11 270 0 0 270 1 1
TBC1D7 DOCK7 0 0 182 181 1 1
TBC1D7 MCRS1 0 0 193 194 1 1
TBC1D7 PLEK 0 0 202 202 1 1
TBC1D7 TBC1D16 0 0 377 400 1 1
TBC1D7 RPS6 0 0 576 576 1 2
TBC1D7 GMPS 0 0 0 156 1 1
TBC1D7 PIK3C3 0 0 204 204 1 2
TBC1D7 PRKG1 0 0 112 152 1 1
TBC1D7 USP6NL 0 0 184 310 1 1
TBC1D7 PLOD3 0 0 0 190 1 1
TBC1D7 STK25 0 0 95 174 1 1
TBC1D7 FADS3 0 0 181 181 1 1
TBC1D7 SH3YL1 0 0 161 161 1 1
TBC1D7 EPHX2 0 0 0 236 1 1
TBC1D7 SGSM2 0 0 268 636 1 1
TBC1D7 SEC13 0 0 342 342 1 1
TBC1D7 CDCA5 0 0 0 152 1 1
TBC1D7 MTFP1 0 0 181 181 1 1
TBC1D7 LAPTM4B 0 0 113 164 1 2
TBC1D7 PHACTR3 0 0 0 226 1 1
TBC1D7 SLC1A7 0 0 241 240 1 1
TBC1D7 ASAP1 0 0 134 227 1 1
TBC1D7 SH3BP4 0 0 294 294 1 1
TBC1D7 SIRT5 0 0 49 318 1 1
TBC1D7 RRAGA 270 0 519 636 1 1
TBC1D7 HIF1A 0 0 150 238 1 2
TBC1D7 NUDT22 0 0 252 333 1 1
TBC1D7 WASF1 0 0 66 418 1 1
TBC1D7 RAC2 0 0 209 209 1 1
TBC1D7 RAB5A 0 0 233 249 1 2
TBC1D7 RAB11A 0 0 150 203 1 2
TBC1D7 CLINT1 0 0 0 188 1 1
TBC1D7 GIMAP2 0 0 0 207 1 1
TBC1D7 RAB17 0 0 537 712 1 1
TBC1D7 GADD45G 0 0 49 203 1 1
TBC1D7 KRT19 432 0 0 432 1 1
TBC1D7 TSC2 752 800 989 999 1 2
TBC1D7 RHO 0 0 57 151 1 2
TBC1D7 RAB7B 0 0 194 194 1 1
TBC1D7 ABCD3 0 0 150 378 1 1
TBC1D7 CITED4 0 0 113 168 1 1
TBC1D7 ODF2 0 0 113 203 1 1
TBC1D7 MCIDAS 0 0 114 305 1 1
TBC1D7 TBC1D22B 0 0 218 353 1 1
TBC1D7 SSNA1 628 0 0 628 1 1
TBC1D7 GIMAP5 0 0 113 514 1 1
TBC1D7 TBC1D3 0 0 325 342 1 1
TBC1D7 HRAS 0 0 90 336 1 2
TBC1D7 MAP1LC3A 270 0 0 270 1 2
TBC1D7 TBC1D30 0 0 393 716 1 1
TBC1D7 DNMT3B 0 0 0 155 1 1
TBC1D7 GPN1 0 0 143 335 1 1
TBC1D7 AKT1 270 800 450 912 1 2
TBC1D7 CYTH4 0 0 155 165 1 1
TBC1D7 ME1 0 0 0 188 1 1
TBC1D7 GSTM3 0 0 0 210 1 1
TBC1D7 ZNF552 0 0 267 267 1 1
TBC1D7 USO1 0 0 123 198 1 1
TBC1D7 EVI5 0 0 253 549 1 1
TBC1D7 ATF4 0 0 165 165 1 2
TBC1D7 PHLPP1 270 0 222 460 1 2
TBC1D7 ACOX2 0 0 0 189 1 1
TBC1D7 ACOXL 0 0 49 200 1 1
TBC1D7 PRR5 0 0 455 459 1 1
TBC1D7 IKBKB 0 800 138 820 1 2
TBC1D7 MAP2K7 0 0 170 169 1 1
TBC1D7 SLC36A1 0 0 160 167 1 1
TBC1D7 NNT 0 0 0 277 1 1
TBC1D7 SLC6A5 0 0 0 189 1 1
TBC1D7 PLA1A 0 0 113 250 1 1
TBC1D7 TPD52L2 0 0 141 282 1 1
TBC1D7 AGFG2 0 0 0 186 1 1
TBC1D7 LARS2 0 0 343 351 1 1
TBC1D7 ARF4 0 0 112 167 1 1
TBC1D7 TBC1D12 0 0 293 612 1 1
TBC1D7 KIAA0247 0 0 208 351 1 1
TBC1D7 CDC16 0 0 726 727 1 1
TBC1D7 GRTP1 0 0 173 261 1 1
TBC1D7 USH2A 0 0 57 165 1 1
TBC1D7 TYMS 0 0 0 167 1 1
TBC1D7 GRB10 0 0 212 212 1 1
TBC1D7 EIF4EBP1 0 0 457 457 1 2
TBC1D7 TBC1D3B 0 0 455 469 1 1
TBC1D7 GPN3 0 0 181 349 1 1
TBC1D7 ARL3 0 0 183 229 1 1
TBC1D7 ARF1 0 0 233 232 1 1
TBC1D7 SEH1L 0 0 376 376 1 1
TBC1D7 ZKSCAN3 0 0 200 200 1 2
TBC1D7 GUCA1B 0 0 107 464 1 1
TBC1D7 C12orf66 0 0 464 463 1 1
TBC1D7 CCNB1 0 0 0 168 1 1
TBC1D7 NPM2 0 0 101 157 1 1
TBC1D7 SLC38A9 0 0 504 508 1 1
TBC1D7 LAMTOR5 0 0 423 422 1 1
TBC1D7 LAMTOR3 0 0 391 390 1 1
TBC1D7 EFNA5 0 0 460 459 1 1
TBC1D7 MND1 0 0 0 167 1 1
TBC1D7 SEC16A 0 0 90 262 1 2
TBC1D7 TFRC 0 0 49 188 1 1
TBC1D7 VPS39 0 0 181 181 1 1
TBC1D7 SLC6A7 0 0 0 302 1 1
TBC1D7 SPTSSB 0 0 0 153 1 1
TBC1D7 RPS6KA2 0 600 372 738 1 1
TBC1D7 LAMTOR2 0 0 367 367 1 1
TBC1D7 ITFG2 0 0 392 430 1 1
TBC1D7 EIF5B 0 0 66 194 1 1
TBC1D7 RAB7A 0 0 194 194 1 2
TBC1D7 GLRX2 0 0 0 221 1 1
TBC1D7 SSR1 0 0 108 573 1 1
TBC1D7 STK11 0 0 294 294 1 2
TBC1D7 ENSG00000248751 0 0 0 207 1 1
TBC1D7 ANKRD27 0 0 42 206 1 1
TBC1D7 UNK 0 0 57 227 1 1
TBC1D7 LARP1 0 0 213 335 1 1
TBC1D7 RB1CC1 0 0 203 203 1 2
TBC1D7 RAB23 0 0 294 450 1 2
TBC1D7 GFOD2 0 0 0 313 1 1
TBC1D7 DCAF5 0 0 203 340 1 1
TBC1D7 RHEBL1 0 0 419 418 1 1
TBC1D7 PLOD2 0 0 64 546 1 1
TBC1D7 CIDEA 0 0 46 262 1 1
TBC1D7 IGF1 0 0 167 167 1 2
TBC1D7 MAPK1 0 800 0 800 1 2
TBC1D7 AKT2 0 800 123 817 1 2
TBC1D7 XDH 0 0 0 231 1 1
TBC1D7 KIF2C 198 0 0 257 1 1
TBC1D7 LIG4 0 0 54 271 1 1
TBC1D7 LARS 0 0 392 419 1 1
TBC1D7 PIH1D1 292 0 166 447 1 1
TBC1D7 RHAG 0 0 0 151 1 1
TBC1D7 MYC 0 0 123 216 1 2
TBC1D7 TBC1D24 0 0 294 294 1 1
TBC1D7 SLC6A9 0 0 95 459 1 1
TBC1D7 UCK2 0 0 112 305 1 1
TBC1D7 PIK3R2 0 0 180 185 1 1
TBC1D7 MAD2L1 0 0 0 181 1 1
TBC1D7 IFT20 0 0 120 193 1 1
TBC1D7 PIK3CA 0 0 147 165 1 2
TBC1D7 AJAP1 0 0 249 277 1 1
TBC1D7 TBC1D31 0 0 174 173 1 1
TBC1D7 EEF2 0 0 204 205 1 2
TBC1D7 FNIP2 0 0 234 239 1 1
TBC1D7 PIM1 0 0 0 173 1 1
TBC1D7 RICTOR 0 0 465 465 1 2
TBC1D7 EFTUD2 0 0 84 150 1 1
TBC1D7 SLC2A4RG 0 0 0 171 1 1
TBC1D7 RUVBL2 270 0 56 297 1 1
TBC1D7 CENPH 0 0 0 156 1 1
TBC1D7 TBC1D10C 0 0 240 413 1 1
TBC1D7 APOA1BP 0 0 370 370 1 1
TBC1D7 NTS 0 0 0 154 1 1
TBC1D7 TBC1D17 0 0 181 404 1 1
TBC1D7 GSTK1 0 0 0 210 1 1
TBC1D7 TP53I3 0 0 89 154 1 1
TBC1D7 NPRL2 0 0 460 463 1 1
TBC1D7 SGSM3 0 0 234 527 1 1
TBC1D7 SZT2 0 0 425 482 1 1
TBC1D7 EEF1E1 0 0 0 185 1 1
TBC1D7 WASF3 0 0 0 156 1 1
TBC1D7 NGFRAP1 0 0 217 217 1 1
TBC1D7 MLANA 0 0 0 159 1 1
TBC1D7 ZBTB10 0 0 82 223 1 1
TBC1D7 DDX46 0 0 0 155 1 1
TBC1D7 RHEB 0 800 793 959 1 2
TBC1D7 DDIT4 0 800 391 873 1 2
TBC1D7 MCM10 0 0 60 156 1 1
TBC1D7 MAP4K3 0 0 142 160 1 1
TBC1D7 C7orf60 0 0 248 248 1 1
TBC1D7 CPVL 270 0 0 270 1 1
TBC1D7 UBE2T 0 0 74 209 1 1
TBC1D7 PDPK1 0 0 210 220 1 2
TBC1D7 RAB8A 0 0 218 239 1 2
TBC1D7 LAMTOR4 0 0 517 517 1 1
TBC1D7 RAB3IP 0 0 219 220 1 1
TBC1D7 GLRX5 0 0 0 207 1 1
TBC1D7 EIF4E 0 0 342 342 1 2
TBC1D7 CDK1 0 0 54 150 1 2
TBC1D7 REM1 0 0 0 188 1 1
TBC1D7 TOR1A 0 0 0 153 1 1
TBC1D7 HIVEP1 0 0 113 587 1 1
TBC1D7 RPS6KB1 0 0 500 506 1 2
TBC1D7 GART 0 0 0 226 1 1
TBC1D7 CREBL2 0 0 181 326 1 1
TBC1D7 SGK1 0 0 319 319 1 2
TBC1D7 IRS1 0 0 234 234 1 2
TBC1D7 PRPS2 0 0 194 194 1 1
TBC1D7 SESN1 0 0 194 194 1 1
TBC1D7 IPMK 0 0 172 171 1 1
TBC1D7 TBC1D13 0 0 193 391 1 1
TBC1D7 CHAF1B 0 0 0 154 1 1
TBC1D7 SLC7A5 0 0 156 214 1 1
TBC1D7 PPP1R37 0 0 254 443 1 1
TBC1D7 RAB10 0 0 276 286 1 1
TBC1D7 EXO1 0 0 0 163 1 1
TBC1D7 QPCT 0 0 96 210 1 1
TBC1D7 PLOD1 0 0 0 190 1 1
TBC1D7 TTLL10 0 0 140 506 1 1
TBC1D7 GPR143 0 0 108 172 1 1
TBC1D7 TBC1D20 0 0 324 539 1 1
TBC1D7 PRKAA1 0 800 0 805 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005096 Molecular Function GTPase activator activity enables IBA
GO:0005096 Molecular Function GTPase activator activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0031267 Molecular Function small GTPase binding enables IPI
GO:0090630 Biological Process activation of GTPase activity involved_in IBA
GO:0090630 Biological Process activation of GTPase activity involved_in IMP
GO:0009267 Biological Process cellular response to starvation involved_in IDA
GO:0032007 Biological Process negative regulation of TOR signaling involved_in IBA
GO:0032007 Biological Process negative regulation of TOR signaling involved_in IDA
GO:0032007 Biological Process negative regulation of TOR signaling involved_in IMP
GO:1904262 Biological Process negative regulation of TORC1 signaling involved_in IDA
GO:1902018 Biological Process negative regulation of cilium assembly involved_in IMP
GO:0043547 Biological Process positive regulation of GTPase activity involved_in IDA
GO:0031398 Biological Process positive regulation of protein ubiquitination involved_in IDA
GO:0070848 Biological Process response to growth factor involved_in IMP
GO:0033596 Cellular Component TSC1-TSC2 complex part_of IDA
GO:0033596 Cellular Component TSC1-TSC2 complex part_of IPI
GO:0036064 Cellular Component ciliary basal body located_in IDA
GO:0031410 Cellular Component cytoplasmic vesicle located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005765 Cellular Component lysosomal membrane is_active_in IDA
Pathways
Name DB ID
Membrane Trafficking Reactome R-HSA-199991
Vesicle-mediated transport Reactome R-HSA-5653656
TBC/RABGAPs Reactome R-HSA-8854214
Rab regulation of trafficking Reactome R-HSA-9007101
Fragile X syndrome (WP4549) WikiPathways WP4549_r124287
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001143966 4 mRNA transcript variant 4 NC_000006 Reference
NM_001258457 3 mRNA transcript variant 5 NC_000006 Reference
NM_001143965 4 mRNA transcript variant 3 NC_000006 Reference
NM_001318805 2 mRNA transcript variant 6 NC_000006 Reference
NM_001143964 4 mRNA transcript variant 2 NC_000006 Reference
NM_016495 6 mRNA transcript variant 1 NC_000006 Reference
NM_001318806 2 mRNA transcript variant 7 NC_000006 Reference