STK26

serine/threonine kinase 26

General Information

Name	serine/threonine kinase 26
Alias	serine/threonine-protein kinase 26 Mst3 and SOK1-related kinase STE20-like kinase 4 STE20-like kinase MST4 mammalian Ste20-like protein kinase 4 mammalian sterile 20-like 4 serine/threonine protein kinase 26 serine/threonine protein kinase MST4 serine/threonine-protein kinase MASK
Gene_family	STRIPAK complex
organism	Homo sapiens
entrez_id	51765
location	Xq26.2
transcript_count	5
exon_count	13

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

nextProt Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556).

Interactions

NCBI

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STK26	BioGRID	CLEC16A	GeneID	BioGRID	Affinity Capture-MS
STK26	BioGRID	RICTOR	GeneID	BioGRID	Proximity Label-MS
STK26	BioGRID	PDCD10	GeneID	BioGRID	Affinity Capture-MS; Co-fractionation; Two-hybrid
STK26	BioGRID	RBM4B	GeneID	BioGRID	Affinity Capture-MS
STK26	BioGRID	FDXR	GeneID	BioGRID	Affinity Capture-MS
STK26	BioGRID	STIP1	GeneID	BioGRID	Affinity Capture-MS
STK26	BioGRID	HSPA5	GeneID	BioGRID	Affinity Capture-MS
STK26	BioGRID	STRIP1	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western
STK26	BioGRID	CTTNBP2	GeneID	BioGRID	Affinity Capture-MS; Affinity Capture-Western
STK26	BioGRID	SIKE1	GeneID	BioGRID	Affinity Capture-MS

Showing 1 to 10 of 190 entries

StringDB

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MST4	MAPK10	0	47	163	2	1
MST4	MAPK14	0	95	289	2	1
MST4	PRKAA2	0	69	185	2	1
MST4	MBP	213	124	300	2	1
MST4	AKT3	0	0	193	2	1
MST4	CAPNS1	245	0	270	2	1
MST4	SIRT1	0	0	193	2	1
MST4	TRAF3	0	120	166	2	1
MST4	LRRK2	270	75	438	2	1
MST4	TLR2	0	0	182	2	1

Showing 1 to 10 of 77 entries

Ontologies

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GO:0000287	Molecular Function	magnesium ion binding	enables	IDA
GO:0004672	Molecular Function	protein kinase activity	enables	IDA
GO:0004672	Molecular Function	protein kinase activity	enables	IMP
GO:0004674	Molecular Function	protein serine/threonine kinase activity	enables	IBA
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0005524	Molecular Function	ATP binding	enables	IDA
GO:0005737	Cellular Component	cytoplasm	is_active_in	IBA
GO:0005737	Cellular Component	cytoplasm	located_in	IDA
GO:0005794	Cellular Component	Golgi apparatus	is_active_in	IBA
GO:0005794	Cellular Component	Golgi apparatus	located_in	IDA

Showing 1 to 10 of 33 entries

Pathways

Name	DB	ID
Apoptosis	Reactome	R-HSA-109581
Apoptotic cleavage of cellular proteins	Reactome	R-HSA-111465
Programmed Cell Death	Reactome	R-HSA-5357801
Apoptotic execution phase	Reactome	R-HSA-75153

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_016542	4	mRNA	transcript variant 1	NC_000023	Reference
NM_001042453	2	mRNA	transcript variant 2	NC_000023	Reference
XM_047442155	1	mRNA	transcript variant X1	NC_000023	Reference
XM_047442156	1	mRNA	transcript variant X2	NC_000023	Reference
NM_001042452	2	mRNA	transcript variant 3	NC_000023	Reference