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PI3

peptidase inhibitor 3
General Information
Name peptidase inhibitor 3
Alias
  • elafin
  • PI-3
  • WAP four-disulfide core domain 14
  • WAP four-disulfide core domain protein 14
  • elastase-specific inhibitor
  • peptidase inhibitor 3, skin-derived
  • pre-elafin
  • protease inhibitor 3, skin-derived (SKALP)
  • protease inhibitor WAP3
  • skin-derived antileukoproteinase
  • trappin-2
Gene_family WAP four-disulfide core domain containing
organism Homo sapiens
entrez_id 5266
location 20q13.12
transcript_count 1
exon_count 3
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
    Stringdb Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing
    nextProt Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
PI3 BioGRID PINK1 GeneID BioGRID Affinity Capture-MS
PI3 BioGRID PPP2R2B GeneID BioGRID Affinity Capture-MS
PI3 BioGRID CCR1 GeneID BioGRID Affinity Capture-MS
PI3 Protein EVPL GeneID HPRD
PI3 Protein CELA1 GeneID HPRD
PI3 BioGRID LORICRIN GeneID BioGRID Reconstituted Complex
PI3 BioGRID KRT1 GeneID BioGRID Reconstituted Complex
PI3 BioGRID CSTA GeneID BioGRID Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
PI3 XIAP 0 0 181 181 1 2
PI3 SERPINB6 0 0 460 467 1 1
PI3 PPP2R4 0 0 241 240 1 1
PI3 FMOD 0 0 453 453 1 1
PI3 DROSHA 0 0 181 181 1 1
PI3 KRT6A 0 0 256 342 1 1
PI3 DUOX1 0 0 108 163 1 1
PI3 BMX 0 0 143 168 1 1
PI3 IKBKB 0 0 167 167 1 2
PI3 NTRK2 0 0 252 252 1 1
PI3 DEFB104B 0 0 202 202 1 1
PI3 LCE3C 0 600 64 609 1 1
PI3 VCAM1 0 0 193 193 1 1
PI3 CD4 0 0 334 334 1 2
PI3 INPP5D 0 0 391 390 1 1
PI3 KLK14 0 0 244 243 1 1
PI3 CPE 0 0 66 164 1 1
PI3 SGK3 0 0 233 232 1 1
PI3 CSF2 0 0 266 281 1 1
PI3 MTMR14 0 0 178 177 1 2
PI3 PPARG 0 0 289 288 1 2
PI3 AKT1 0 0 988 988 1 2
PI3 CCZ1B 0 0 448 448 1 1
PI3 KLK4 0 0 258 258 1 1
PI3 KLK1 0 0 252 282 1 1
PI3 CD34 0 0 181 181 1 2
PI3 NGF 0 0 445 445 1 2
PI3 ERBB2 0 0 391 390 1 2
PI3 RPTN 0 900 141 910 1 1
PI3 GFPT2 0 0 108 205 1 1
PI3 TLR9 0 0 219 219 1 2
PI3 CXCL10 0 0 270 305 1 2
PI3 PIKFYVE 0 0 673 673 1 2
PI3 EIF4EBP1 0 0 282 282 1 2
PI3 KRT18 0 0 204 204 1 1
PI3 CST6 0 0 207 207 1 1
PI3 KLKB1 0 0 161 161 1 1
PI3 OSGEP 0 0 103 262 1 1
PI3 RNASE7 0 0 403 525 1 1
PI3 SERPINB3 0 0 294 395 1 1
PI3 TP53INP1 0 0 350 349 1 2
PI3 LRPAP1 0 0 156 155 1 1
PI3 A2M 0 0 193 194 1 1
PI3 EIF2AK3 0 0 300 300 1 2
PI3 SERPINB7 0 0 180 264 1 1
PI3 LGALS3 0 0 151 176 1 2
PI3 ATG3 0 0 281 281 1 2
PI3 TLR3 0 0 208 208 1 2
PI3 RABGEF1 0 0 184 183 1 1
PI3 PLSCR1 0 0 456 456 1 1
PI3 IL19 0 0 205 205 1 1
PI3 IRS4 0 0 142 205 1 1
PI3 CDC42 0 0 337 348 1 2
PI3 HP 0 0 153 152 1 1
PI3 SRC 0 0 529 529 1 2
PI3 SLC2A4 0 0 376 376 1 1
PI3 FOXO3 0 0 241 240 1 2
PI3 GFM1 0 0 45 529 1 1
PI3 APOE 0 0 180 179 1 2
PI3 EEA1 0 0 816 816 1 2
PI3 BPI 0 0 301 378 1 1
PI3 PRKCD 0 0 157 156 1 2
PI3 CDKN1B 0 0 258 258 1 2
PI3 ZFYVE1 0 0 785 785 1 2
PI3 REG3A 0 0 468 468 1 1
PI3 PIP4K2B 0 0 156 170 1 1
PI3 HCAR3 0 0 48 161 1 1
PI3 RAB7B 0 0 404 404 1 1
PI3 STAT5B 0 0 246 245 1 1
PI3 TRRAP 0 0 172 171 1 1
PI3 TSC2 0 0 280 280 1 2
PI3 PIK3C2A 0 0 270 270 1 1
PI3 SCGB1A1 0 0 154 153 1 1
PI3 SBF2 0 0 181 181 1 1
PI3 CSN3 0 0 453 453 1 1
PI3 KDR 0 0 261 261 1 2
PI3 JAK1 0 0 180 179 1 2
PI3 MMP12 0 0 234 272 1 1
PI3 RAB11A 0 0 211 211 1 2
PI3 RAC2 0 0 243 309 1 1
PI3 STX17 0 0 186 186 1 2
PI3 TCHP 0 0 202 202 1 1
PI3 TBK1 0 0 95 160 1 2
PI3 HMOX1 0 0 212 212 1 2
PI3 FOXP3 0 0 193 193 1 2
PI3 IL32 0 0 202 231 1 1
PI3 PDPK1 0 0 231 236 1 2
PI3 IDE 0 0 125 164 1 1
PI3 PTK2B 0 0 209 209 1 1
PI3 PECAM1 0 0 155 181 1 1
PI3 CAT 0 0 216 216 1 2
PI3 LCE1E 0 600 0 600 1 1
PI3 GINM1 0 0 187 187 1 1
PI3 ENSG00000264813 0 0 151 150 1 1
PI3 SFTPD 0 0 183 183 1 1
PI3 HGF 0 0 361 361 1 2
PI3 CDIPT 0 0 106 583 1 1
PI3 TXN 0 0 128 219 1 1
PI3 BMPR2 0 0 217 217 1 1
PI3 DEFA1 0 0 124 160 1 1
PI3 CD38 0 0 162 161 1 2
PI3 ANXA7 0 0 480 480 1 1
PI3 RHEB 0 0 260 260 1 2
PI3 S100A7A 0 0 258 279 1 1
PI3 NADSYN1 0 0 0 191 1 1
PI3 PACS1 0 0 0 188 1 1
PI3 CTLA4 0 0 218 218 1 2
PI3 WFDC12 0 0 720 720 1 1
PI3 EHF 0 0 0 237 1 1
PI3 SEMA3A 0 0 142 201 1 1
PI3 NR5A1 0 0 441 441 1 1
PI3 NOS3 0 0 409 408 1 2
PI3 CCND1 0 0 323 323 1 2
PI3 CD274 0 0 126 156 1 2
PI3 ATR 0 0 234 234 1 2
PI3 SNX9 0 0 142 212 1 1
PI3 LCE3D 0 600 90 642 1 1
PI3 DEFA1B 0 0 134 152 1 1
PI3 FAU 0 0 102 158 1 2
PI3 VNN2 0 0 97 153 1 1
PI3 NCF1 0 0 163 183 1 1
PI3 LOX 0 0 161 161 1 2
PI3 PIK3C2B 0 0 194 194 1 1
PI3 CBL 0 0 295 295 1 1
PI3 IRS1 0 0 505 505 1 2
PI3 SGK1 0 0 234 234 1 2
PI3 IPMK 0 0 180 179 1 1
PI3 EPOR 0 0 181 181 1 1
PI3 NTRK1 0 0 320 319 1 1
PI3 SERPINE1 0 0 193 193 1 1
PI3 PRKDC 0 0 406 406 1 2
PI3 SLPI 0 0 769 622 1 1
PI3 MUC1 0 0 129 175 1 1
PI3 PGR 0 0 156 155 1 1
PI3 EIF4E 0 0 195 195 1 2
PI3 LCE3A 0 600 82 617 1 1
PI3 HBD 0 0 244 275 1 1
PI3 RPS6KB1 0 0 365 365 1 2
PI3 BTK 0 0 270 270 1 1
PI3 WDR45 0 0 404 404 1 2
PI3 WDFY3 0 0 271 271 1 2
PI3 DEFB4A 0 0 607 626 1 1
PI3 CYTH3 0 0 165 165 1 1
PI3 UVRAG 0 0 329 329 1 2
PI3 MAPK1 0 0 211 211 1 2
PI3 ITIH4 0 0 218 235 1 1
PI3 IGF1 0 0 459 459 1 2
PI3 RETN 0 0 193 193 1 1
PI3 SPRR2B 0 600 113 640 1 1
PI3 C1orf64 0 0 0 248 1 1
PI3 MMP8 0 0 240 239 1 1
PI3 ENSG00000196136 0 0 294 294 1 1
PI3 S100A9 0 0 167 410 1 1
PI3 FGF2 0 0 235 235 1 2
PI3 RAB7A 0 0 438 438 1 2
PI3 CXCL3 0 0 102 155 1 1
PI3 PIK3C2G 0 0 217 217 1 1
PI3 GCG 0 0 174 173 1 1
PI3 RPS6KA2 0 0 193 193 1 1
PI3 VWF 0 0 123 177 1 1
PI3 IL1R2 0 0 127 261 1 1
PI3 NFAT5 0 0 398 398 1 1
PI3 IL23R 0 0 87 293 1 1
PI3 WIPI2 0 0 478 478 1 2
PI3 WFDC13 0 0 154 160 1 1
PI3 ALDH7A1 0 0 150 180 1 1
PI3 MMP7 0 0 150 174 1 1
PI3 IL1RN 0 0 206 350 1 1
PI3 MMP3 0 0 187 216 1 1
PI3 MTMR1 0 0 141 166 1 1
PI3 PIK3R2 0 0 325 325 1 1
PI3 VPS36 0 0 477 477 1 1
PI3 CD44 0 0 224 243 1 2
PI3 BDNF 0 0 324 323 1 2
PI3 IL7 0 0 158 157 1 1
PI3 ITK 0 0 134 197 1 1
PI3 KRT14 0 0 167 213 1 1
PI3 SERPINB13 0 0 293 329 1 1
PI3 LCE1C 0 600 0 600 1 1
PI3 VPS11 0 0 245 244 1 1
PI3 SACM1L 0 0 194 194 1 1
PI3 SEMA4D 0 0 160 159 1 1
PI3 NBR1 0 0 142 201 1 2
PI3 PRRC2C 0 0 0 290 1 1
PI3 TNF 0 0 465 478 1 2
PI3 ELN 0 0 494 494 1 1
PI3 TTF1 0 0 0 167 1 1
PI3 LCE6A 0 600 0 600 1 1
PI3 PTPN1 0 0 193 193 1 1
PI3 IRF1 0 0 180 206 1 2
PI3 ATG5 0 0 335 335 1 2
PI3 SPRR2E 0 600 0 627 1 1
PI3 TLR8 0 0 124 155 1 1
PI3 WDR18 0 0 467 467 1 1
PI3 DSG1 0 0 210 210 1 1
PI3 ITGAM 0 0 136 153 1 1
PI3 LYN 0 0 293 293 1 1
PI3 ESR1 0 0 310 309 1 2
PI3 DUOX2 0 0 123 236 1 1
PI3 RAC1 0 0 162 176 1 2
PI3 IFNB1 0 0 211 211 1 1
PI3 TP53BP1 0 0 173 173 1 1
PI3 CTSB 0 0 167 167 1 2
PI3 KCNS1 0 0 48 291 1 1
PI3 UBTF 0 0 326 325 1 1
PI3 INPP4A 0 0 232 233 1 1
PI3 MCL1 0 0 260 260 1 2
PI3 FN1 0 0 864 864 1 2
PI3 TBP 0 0 95 157 1 1
PI3 TGM3 0 0 193 251 1 1
PI3 TFF2 0 0 136 154 1 1
PI3 SNX5 0 0 193 211 1 1
PI3 AKT3 0 0 321 321 1 2
PI3 RPS6KA1 0 0 195 195 1 1
PI3 ELANE 0 0 723 723 1 1
PI3 PRKCA 0 0 156 170 1 1
PI3 NBN 0 0 131 190 1 1
PI3 ULK1 0 0 294 294 1 2
PI3 SERPINB5 0 0 558 591 1 1
PI3 MAP1LC3B 0 0 151 150 1 2
PI3 S100P 0 0 48 189 1 1
PI3 SERPINB9 0 0 321 330 1 1
PI3 SERPINB8 0 0 342 357 1 1
PI3 ADAM17 0 0 155 154 1 1
PI3 LOR 270 600 457 827 1 1
PI3 ATG10 0 0 211 211 1 2
PI3 S100A4 0 0 143 164 1 1
PI3 CST4 0 0 195 195 1 1
PI3 ADI1 0 0 65 229 1 1
PI3 WFDC1 0 0 393 532 1 1
PI3 VAV1 0 0 167 188 1 1
PI3 CMA1 0 0 193 203 1 1
PI3 GLI1 0 0 165 165 1 2
PI3 NCF2 0 0 142 192 1 1
PI3 IL10 0 0 325 325 1 2
PI3 CCL20 0 0 454 510 1 1
PI3 HBB 0 0 155 224 1 1
PI3 FLT3 0 0 160 159 1 2
PI3 IRAK4 0 0 151 150 1 1
PI3 CXCL2 0 0 164 194 1 1
PI3 SELE 0 0 193 193 1 1
PI3 TJP1 0 0 202 202 1 1
PI3 MARCKS 0 0 367 367 1 1
PI3 ATG7 0 0 284 284 1 2
PI3 COL17A1 0 0 74 167 1 1
PI3 RET 0 0 187 187 1 1
PI3 KLK6 0 0 325 325 1 1
PI3 HOXA1 0 0 0 163 1 1
PI3 CTSG 0 0 505 505 1 1
PI3 CCL3 0 0 208 222 1 1
PI3 FCGR3B 0 0 113 172 1 1
PI3 SPRR2F 0 600 0 600 1 1
PI3 IGF2 0 0 206 206 1 1
PI3 AMPH 0 0 193 205 1 1
PI3 CTSD 0 0 211 211 1 2
PI3 KCNA3 0 0 165 165 1 1
PI3 ATM 0 0 468 468 1 2
PI3 SHC1 0 0 397 397 1 1
PI3 THBD 0 0 112 364 1 1
PI3 PDZK1IP1 0 0 57 226 1 1
PI3 NTF4 0 0 181 181 1 1
PI3 CFL1 0 0 194 194 1 1
PI3 MAPK14 0 0 325 325 1 2
PI3 NGFR 0 0 171 171 1 1
PI3 AMBRA1 0 0 210 210 1 2
PI3 SKAP1 0 0 278 278 1 1
PI3 LEP 0 0 247 246 1 1
PI3 SYK 0 0 283 282 1 2
PI3 KIT 0 0 241 240 1 2
PI3 NFKBIA 0 0 262 262 1 2
PI3 WIPI1 0 0 573 573 1 2
PI3 PLN 0 0 0 173 1 1
PI3 NTRK3 0 0 137 196 1 1
PI3 PI4KB 0 0 205 205 1 1
PI3 KRT16 0 0 468 522 1 1
PI3 VEGFA 0 0 454 454 1 2
PI3 GABARAP 0 0 193 193 1 2
PI3 PTEN 0 0 566 566 1 2
PI3 CXCL1 0 0 249 360 1 2
PI3 PLD2 0 0 149 235 1 1
PI3 GFPT1 0 0 75 176 1 1
PI3 ATG101 0 0 217 217 1 2
PI3 ELF3 0 0 95 453 1 1
PI3 MMP14 0 0 119 169 1 1
PI3 PGLYRP1 0 0 140 161 1 1
PI3 GPA33 0 0 51 196 1 1
PI3 KRT6B 0 0 216 325 1 1
PI3 VPS29 0 0 139 198 1 1
PI3 PTGS2 0 0 234 272 1 2
PI3 SLC6A14 0 0 166 190 1 1
PI3 ERBB3 0 0 280 280 1 1
PI3 CASP3 0 0 390 390 1 2
PI3 F3 0 0 103 164 1 1
PI3 KLK5 0 0 318 334 1 1
PI3 ACE 0 0 171 171 1 1
PI3 TNFSF13B 0 0 209 209 1 1
PI3 REN 0 0 157 156 1 1
PI3 ATG12 0 0 393 393 1 2
PI3 IL13 0 0 241 240 1 2
PI3 CYBB 0 0 180 185 1 2
PI3 CD28 0 0 180 179 1 1
PI3 HELLS 0 0 0 258 1 1
PI3 CXCL5 0 0 123 155 1 1
PI3 CSTB 0 0 249 300 1 1
PI3 SPRR2D 0 600 0 629 1 1
PI3 CDKN2A 0 0 289 288 1 2
PI3 SFN 0 0 124 176 1 2
PI3 ADM 0 0 162 194 1 2
PI3 ST14 0 0 108 154 1 1
PI3 WFDC5 0 0 373 520 1 1
PI3 GSK3B 0 0 155 154 1 2
PI3 XRCC5 0 0 203 203 1 1
PI3 NTF3 0 0 171 171 1 1
PI3 LCE5A 0 600 0 600 1 1
PI3 KLK11 0 0 184 183 1 1
PI3 LCE2B 0 600 90 620 1 1
PI3 PIGR 0 0 151 169 1 1
PI3 TCN1 0 0 74 169 1 1
PI3 CHUK 0 0 142 175 1 1
PI3 S100A12 0 0 324 517 1 1
PI3 HCK 0 0 172 188 1 1
PI3 TSPO 0 0 386 400 1 1
PI3 NOD2 0 0 171 210 1 2
PI3 CEBPB 0 0 123 155 1 2
PI3 ATG16L1 0 0 294 294 1 2
PI3 PIK3CD 0 0 536 536 1 1
PI3 INPP4B 0 0 228 227 1 1
PI3 FOS 0 0 261 261 1 2
PI3 FASLG 0 0 193 193 1 1
PI3 S100A8 0 0 181 361 1 2
PI3 IL31 0 0 180 179 1 1
PI3 RHOD 0 0 174 173 1 1
PI3 SOCS3 0 0 146 167 1 1
PI3 SEMG1 0 0 645 654 1 1
PI3 STAT5A 0 0 248 248 1 1
PI3 GAB1 0 0 113 206 1 1
PI3 PTPN11 0 0 722 722 1 1
PI3 RNASE6 0 0 95 198 1 1
PI3 CRKL 0 0 150 257 1 1
PI3 CASP14 0 900 66 902 1 1
PI3 ZNRF3 0 0 0 216 1 1
PI3 MLST8 0 0 185 185 1 1
PI3 SNX2 0 0 155 156 1 1
PI3 KRAS 0 0 324 323 1 2
PI3 FOXO1 0 0 293 293 1 2
PI3 PKN2 0 0 103 163 1 1
PI3 RNASE8 0 0 0 150 1 1
PI3 KLK9 0 0 205 234 1 1
PI3 ADRBK1 0 0 97 156 1 1
PI3 ADO 0 0 95 586 1 1
PI3 CCL17 0 0 180 179 1 1
PI3 TUT1 0 0 156 155 1 1
PI3 SDC1 0 0 150 156 1 1
PI3 SPRR3 0 600 234 699 1 1
PI3 BECN1 0 0 408 408 1 2
PI3 ARF6 0 0 154 153 1 1
PI3 IL2 0 0 270 270 1 1
PI3 VAC14 0 0 391 390 1 1
PI3 CDKN2B 0 0 102 167 1 1
PI3 PIK3CB 0 0 458 457 1 1
PI3 TLR2 0 0 268 289 1 2
PI3 DUSP1 0 0 162 161 1 1
PI3 MET 0 0 243 242 1 2
PI3 WARS 0 0 170 169 1 1
PI3 WAS 0 0 140 235 1 1
PI3 SNX16 0 0 454 454 1 1
PI3 PGF 0 0 144 155 1 1
PI3 SERPINB4 0 0 345 411 1 1
PI3 FGFR2 0 0 108 159 1 1
PI3 TLR4 0 0 294 294 1 2
PI3 SMAD2 0 0 194 194 1 2
PI3 GAPDH 0 0 322 321 1 2
PI3 ATG14 0 0 632 632 1 2
PI3 GABARAPL2 0 0 325 325 1 2
PI3 SMG1 0 0 261 265 1 1
PI3 OAS2 0 0 155 172 1 1
PI3 FCGBP 0 0 0 463 1 1
PI3 DEFB105A 0 0 204 204 1 1
PI3 MAP2K7 0 0 508 508 1 1
PI3 ABL1 0 0 218 218 1 1
PI3 NF1 0 0 161 161 1 1
PI3 PIK3R4 0 0 418 418 1 2
PI3 PI15 0 0 217 217 1 1
PI3 TOM1 0 0 58 225 1 1
PI3 KITLG 0 0 182 181 1 1
PI3 CASP6 0 0 66 164 1 1
PI3 ZAP70 0 0 122 186 1 1
PI3 TCHH 0 900 103 906 1 1
PI3 EVPL 213 600 140 713 1 1
PI3 NFKB1 0 0 384 384 1 2
PI3 CCL4L1 0 0 159 158 1 1
PI3 FYCO1 0 0 157 156 1 2
PI3 PELP1 0 0 163 163 1 2
PI3 PRRC2B 0 0 0 216 1 1
PI3 RELA 0 0 156 155 1 2
PI3 KLK15 0 0 177 177 1 1
PI3 BCL2L1 0 0 335 335 1 2
PI3 WASL 0 0 155 177 1 1
PI3 ANXA5 0 0 247 246 1 2
PI3 KLK2 0 0 151 239 1 1
PI3 CRLS1 0 0 0 187 1 1
PI3 INPPL1 0 0 325 325 1 1
PI3 LCE3B 0 600 66 610 1 1
PI3 SERPINI1 0 0 322 321 1 1
PI3 SERPINI2 0 0 209 209 1 1
PI3 EPO 0 0 160 159 1 2
PI3 IQGAP1 0 0 117 172 1 1
PI3 LCE1D 0 600 0 600 1 1
PI3 SPRR2G 0 600 81 628 1 1
PI3 HCAR2 0 0 0 175 1 1
PI3 CCL13 0 0 180 179 1 1
PI3 ARF1 0 0 150 292 1 1
PI3 FIG4 0 0 325 325 1 1
PI3 HIST2H2AC 0 0 147 195 1 1
PI3 IFNG 0 0 219 219 1 2
PI3 BIRC2 0 0 150 201 1 1
PI3 CREB1 0 0 285 284 1 2
PI3 CCL5 0 0 284 284 1 2
PI3 MPO 0 0 241 240 1 2
PI3 PIK3C3 0 0 565 565 1 2
PI3 IL6 0 0 456 471 1 2
PI3 LYZ 0 0 123 186 1 1
PI3 CTRL 0 0 159 158 1 2
PI3 DEFB1 0 0 454 480 1 1
PI3 STAT1 0 0 216 216 1 2
PI3 OCLN 0 0 181 181 1 1
PI3 PLEK 0 0 468 468 1 1
PI3 RPS6 0 0 180 179 1 2
PI3 TNFRSF1A 0 0 321 321 1 1
PI3 SEMG2 0 0 645 654 1 1
PI3 RRAS 0 0 108 163 1 1
PI3 CDSN 0 600 235 689 1 1
PI3 CXCR4 0 0 310 309 1 2
PI3 CD40LG 0 0 165 165 1 1
PI3 VNN1 0 0 90 202 1 1
PI3 NOTCH1 0 0 235 235 1 2
PI3 MMP1 0 0 233 262 1 1
PI3 LCE2A 0 600 0 600 1 1
PI3 RAD51 0 0 218 218 1 2
PI3 MTOR 0 0 518 518 1 2
PI3 APOBEC3G 0 0 205 205 1 1
PI3 SPINK5 0 0 386 386 1 1
PI3 CD163 0 0 134 329 1 1
PI3 SAA1 0 0 107 172 1 1
PI3 MTMR3 0 0 265 265 1 2
PI3 PSMC6 0 0 174 173 1 1
PI3 LCE1F 0 600 0 600 1 1
PI3 CDK2 0 0 208 208 1 2
PI3 CTNNB1 0 0 466 466 1 2
PI3 HRAS 0 0 379 379 1 2
PI3 TRPV1 0 0 170 169 1 2
PI3 APP 0 0 228 233 1 2
PI3 EGR1 0 0 181 181 1 2
PI3 RHO 0 0 143 159 1 2
PI3 CXCR2 0 0 173 197 1 1
PI3 KRT17 0 0 181 228 1 1
PI3 GPR101 0 0 310 309 1 1
PI3 PACS2 0 0 54 159 1 1
PI3 OAS1 0 0 99 154 1 1
PI3 EDN1 0 0 218 218 1 1
PI3 HIF1A 0 0 293 293 1 2
PI3 PRRC2A 0 0 49 475 1 1
PI3 RAB5A 0 0 555 555 1 2
PI3 MATN4 0 0 112 249 1 1
PI3 IL1B 0 0 426 484 1 2
PI3 DEFB105B 0 0 204 204 1 1
PI3 PIR 0 0 195 195 1 1
PI3 CXCL8 0 0 502 546 1 2
PI3 UNC79 0 0 91 187 1 1
PI3 CTSL 0 0 157 156 1 2
PI3 ARF3 0 0 152 205 1 1
PI3 KLK3 0 0 218 299 1 1
PI3 XRCC6 0 0 218 218 1 1
PI3 MUC5AC 0 0 181 249 1 1
PI3 INPP5E 0 0 90 152 1 1
PI3 OCRL 0 0 194 194 1 1
PI3 KRT5 0 0 139 191 1 1
PI3 AGO2 0 0 302 302 1 2
PI3 TGFA 0 0 166 215 1 1
PI3 DEFA5 0 0 218 235 1 1
PI3 STAT3 0 0 390 390 1 2
PI3 GDNF 0 0 193 193 1 2
PI3 JAK2 0 0 382 382 1 2
PI3 KLK7 0 0 341 341 1 1
PI3 FGR 0 0 167 167 1 1
PI3 TGM1 0 600 295 716 1 1
PI3 SPRR2A 0 600 67 651 1 1
PI3 HGS 0 0 209 209 1 2
PI3 MUC5B 0 0 95 172 1 1
PI3 RAF1 0 0 251 250 1 2
PI3 CSF3 0 0 174 205 1 1
PI3 TXK 0 0 149 202 1 1
PI3 SPRR1B 0 600 252 724 1 1
PI3 SERPINA4 0 0 784 784 1 1
PI3 HAND1 0 0 0 195 1 1
PI3 CAMP 0 0 505 521 1 2
PI3 FGF7 0 0 167 167 1 1
PI3 KRT10 0 0 260 260 1 1
PI3 LCE2D 0 600 0 600 1 1
PI3 GIG25 0 0 294 294 1 1
PI3 TGM2 0 0 179 179 1 2
PI3 TP53 0 0 458 457 1 2
PI3 LCN2 0 0 380 562 1 1
PI3 MDM2 0 0 245 244 1 2
PI3 IVL 0 600 504 800 1 1
PI3 WFDC11 0 0 218 218 1 1
PI3 ZAN 0 0 134 676 1 1
PI3 TSLP 0 0 193 193 1 1
PI3 LAMP1 0 0 186 186 1 2
PI3 SLC2A1 0 0 217 217 1 2
PI3 FGFR3 0 0 123 155 1 1
PI3 MYD88 0 0 193 193 1 2
PI3 DEFB103A 0 0 458 469 1 1
PI3 KRT23 0 0 96 229 1 1
PI3 TNFRSF4 0 0 97 159 1 1
PI3 CDK4 0 0 170 169 1 2
PI3 CFLAR 0 0 170 169 1 2
PI3 EGFR 0 0 468 468 1 2
PI3 RB1CC1 0 0 261 261 1 2
PI3 WFDC8 0 0 279 376 1 1
PI3 TLR1 0 0 150 174 1 1
PI3 NFE2L2 0 0 170 169 1 2
PI3 AKT2 0 0 337 337 1 2
PI3 MTMR2 0 0 432 432 1 1
PI3 FRS2 0 0 170 221 1 1
PI3 PIP4K2A 0 0 273 273 1 1
PI3 DSP 0 0 158 157 1 1
PI3 KRT4 0 0 151 181 1 1
PI3 AREG 0 0 150 181 1 1
PI3 OASL 0 0 107 150 1 1
PI3 BRCA1 0 0 262 262 1 2
PI3 STK11 0 0 205 205 1 2
PI3 MAP2K1 0 0 379 379 1 1
PI3 SMAD4 0 0 166 165 1 2
PI3 CTSE 0 0 171 191 1 1
PI3 DMBT1 0 0 123 598 1 1
PI3 PBK 0 0 66 166 1 1
PI3 CHI3L1 0 0 155 176 1 1
PI3 MX1 0 0 193 193 1 1
PI3 APPL1 0 0 248 248 1 1
PI3 UBTFL1 0 0 106 243 1 1
PI3 RICTOR 0 0 261 261 1 2
PI3 GNAQ 0 0 194 194 1 1
PI3 CELA1 213 0 123 280 1 1
PI3 PIK3R3 0 0 317 317 1 1
PI3 SERPINB10 0 0 201 436 1 1
PI3 GLIPR2 0 0 60 221 1 2
PI3 PIK3CA 0 0 501 501 1 2
PI3 GAB2 0 0 669 669 1 1
PI3 IL2RA 0 0 183 217 1 1
PI3 MYC 0 0 376 376 1 2
PI3 S100A7 0 0 506 549 1 1
PI3 IL1R1 0 0 453 464 1 1
PI3 IFNA1 0 0 241 240 1 1
PI3 ILK 0 0 167 167 1 1
PI3 IL18 0 0 203 232 1 2
PI3 RALGDS 0 0 181 181 1 1
PI3 IGF1R 0 0 342 342 1 2
PI3 IL36G 0 0 305 346 1 1
PI3 LELP1 0 600 139 640 1 1
PI3 FGFBP1 0 0 49 186 1 1
PI3 LTF 0 0 162 205 1 1
PI3 HSPA4 0 0 180 179 1 1
PI3 EPPIN 0 0 309 314 1 1
PI3 TRIM5 0 0 181 181 1 1
PI3 PIK3R1 0 0 459 459 1 1
PI3 DICER1 0 0 181 181 1 1
PI3 WFDC6 0 0 0 443 1 1
PI3 HSPB3 0 0 167 167 1 1
PI3 RPTOR 0 0 284 284 1 2
PI3 LCE4A 0 600 0 600 1 1
PI3 PPARA 0 0 181 181 1 2
PI3 DEFB103B 0 0 459 472 1 1
PI3 CXCL9 0 0 234 260 1 1
PI3 MTM1 0 0 397 396 1 2
PI3 CASP9 0 0 282 282 1 2
PI3 VCAN 0 0 102 158 1 1
PI3 TRAF6 0 0 202 202 1 2
PI3 GDF2 0 0 286 286 1 1
PI3 CYCS 0 0 294 294 1 2
PI3 CHEK2 0 0 292 292 1 1
PI3 RPS6KA3 0 0 218 218 1 1
PI3 RAC3 0 0 123 177 1 2
PI3 TLR7 0 0 170 169 1 2
PI3 CXCL11 0 0 150 193 1 1
PI3 CD163L1 0 0 0 256 1 1
PI3 IL17A 0 0 293 293 1 2
PI3 PLAU 0 0 171 209 1 1
PI3 PRTN3 0 0 676 676 1 1
PI3 LCE1A 0 600 0 600 1 1
PI3 EGF 0 0 451 451 1 2
PI3 ADIPOQ 0 0 202 202 1 2
PI3 PTK2 0 0 211 211 1 2
PI3 MAPK8 0 0 271 271 1 2
PI3 BRAF 0 0 157 156 1 2
PI3 VR1 0 0 438 438 1 1
PI3 TFF1 0 0 170 227 1 1
PI3 TNS1 0 0 343 343 1 1
PI3 IFIH1 0 0 128 152 1 1
PI3 PXN 0 0 169 169 1 1
PI3 HIST2H3PS2 0 0 162 161 1 1
PI3 FLG 0 0 391 390 1 1
PI3 FKBP1A 0 0 218 218 1 2
PI3 GPR56 0 0 0 244 1 1
PI3 PIK3R5 0 0 269 269 1 1
PI3 XRCC4 0 0 276 276 1 1
PI3 SPRR1A 0 600 116 665 1 1
PI3 LGALS4 0 0 171 171 1 1
PI3 H2AFX 0 0 294 294 1 1
PI3 CCL4 0 0 203 220 1 1
PI3 IL1A 0 0 296 331 1 1
PI3 NEFL 0 0 309 309 1 1
PI3 DDX58 0 0 153 152 1 1
PI3 VPS35 0 0 142 201 1 2
PI3 PLG 0 0 183 183 1 1
PI3 SH3PXD2A 0 0 365 365 1 1
PI3 PRKCZ 0 0 232 231 1 1
PI3 VPS26A 0 0 231 230 1 1
PI3 NCF4 0 0 453 464 1 1
PI3 RAP2B 0 0 181 181 1 1
PI3 DEFB4B 0 0 371 393 1 1
PI3 CDH1 0 0 337 337 1 2
PI3 PDGFRB 0 0 193 193 1 2
PI3 A2ML1 0 0 107 188 1 1
PI3 IL4 0 0 271 271 1 1
PI3 IL17F 0 0 95 195 1 1
PI3 ANXA8 0 0 137 163 1 1
PI3 BIRC3 0 0 134 174 1 1
PI3 SMAD3 0 0 181 181 1 2
PI3 KLK10 0 0 241 240 1 1
PI3 ROCK1 0 0 108 163 1 2
PI3 SERPINB1 0 0 564 582 1 1
PI3 ALB 0 0 342 342 1 2
PI3 CASP8 0 0 255 254 1 2
PI3 KNG1 0 0 158 157 1 1
PI3 CCL2 0 0 321 321 1 2
PI3 DSPP 0 0 415 415 1 1
PI3 CASP7 0 0 90 164 1 1
PI3 MBL2 0 0 155 154 1 1
PI3 HIST2H2AA3 0 0 154 153 1 1
PI3 LBP 0 0 94 150 1 1
PI3 SBF1 0 0 443 443 1 1
PI3 HSP90AA1 0 0 453 453 1 2
PI3 IL3 0 0 182 181 1 1
PI3 CRP 0 0 208 208 1 2
PI3 CD40 0 0 183 183 1 2
PI3 WAP7 0 0 324 597 1 1
PI3 HIST2H2AA 0 0 154 153 1 1
PI3 SELP 0 0 141 158 1 1
PI3 INS 0 0 556 556 1 2
PI3 ATG13 0 0 218 218 1 2
PI3 ACTB 0 0 340 340 1 2
PI3 KLK12 0 0 204 233 1 1
PI3 SQSTM1 0 0 228 228 1 2
PI3 SPINT4 0 0 68 477 1 1
PI3 LCE3E 0 600 51 623 1 1
PI3 B2M 0 0 134 158 1 1
PI3 MMP9 0 0 323 363 1 2
PI3 RND1 0 0 157 156 1 1
PI3 MAPK3 0 0 459 459 1 2
PI3 AR 0 0 184 183 1 2
PI3 RHOA 0 0 325 325 1 2
PI3 PARP1 0 0 166 165 1 2
PI3 ZFYVE20 0 0 166 165 1 1
PI3 SPP1 0 0 164 163 1 2
PI3 VPS28 0 0 208 208 1 1
PI3 CDKN1A 0 0 213 213 1 2
PI3 RHOQ 0 0 155 154 1 1
PI3 CCL18 0 0 195 218 1 1
PI3 CXCL12 0 0 267 267 1 2
PI3 TIMP1 0 0 262 262 1 1
PI3 FABP5 0 0 166 165 1 1
PI3 PLA2G1B 0 0 151 150 1 1
PI3 ESR2 0 0 161 161 1 1
PI3 CXCR1 0 0 162 251 1 1
PI3 RHOG 0 0 113 168 1 1
PI3 GABARAPL1 0 0 325 325 1 2
PI3 ICAM1 0 0 263 285 1 2
PI3 CPNE1 0 0 141 375 1 1
PI3 RNF8 0 0 164 163 1 1
PI3 GRB2 0 0 381 381 1 1
PI3 FYN 0 0 262 262 1 1
PI3 KLK13 0 0 262 262 1 1
PI3 LCK 0 0 232 231 1 1
PI3 CSTA 270 900 390 959 1 1
PI3 IL36RN 0 0 157 207 1 1
PI3 CCR5 0 0 260 260 1 1
PI3 TBC1D4 0 0 243 242 1 1
PI3 KRT1 270 0 442 591 1 1
PI3 LCE2C 0 600 0 600 1 1
PI3 PPL 0 600 184 659 1 1
PI3 SNX3 0 0 204 221 1 1
PI3 CAMK1D 0 0 60 203 1 1
PI3 ADAM8 0 0 124 155 1 1
PI3 WDFY1 0 0 342 342 1 1
PI3 CD8A 0 0 282 282 1 1
PI3 IRS2 0 0 473 473 1 1
PI3 ANGPT2 0 0 171 171 1 1
PI3 CRK 0 0 227 241 1 1
PI3 MMP2 0 0 282 282 1 2
PI3 WFDC2 0 0 457 457 1 1
PI3 ENSG00000270024 0 0 226 225 1 1
PI3 MAST2 0 0 109 174 1 1
PI3 AZU1 0 0 154 153 1 1
PI3 CD74 0 0 93 161 1 1
PI3 CHEK1 0 0 293 293 1 2
PI3 SNAP29 0 0 151 150 1 2
PI3 KLK8 0 0 233 232 1 1
PI3 PLAT 0 0 134 197 1 1
PI3 CXCL6 0 0 107 150 1 1
PI3 SNCA 0 0 181 181 1 2
PI3 CASP1 0 0 145 195 1 2
PI3 AKT1S1 0 0 261 261 1 1
PI3 TNFSF10 0 0 177 207 1 2
PI3 CAV1 0 0 216 216 1 2
PI3 CEACAM6 0 0 90 179 1 1
PI3 ERBB4 0 0 202 202 1 1
PI3 DEFB104A 0 0 202 202 1 1
PI3 PIK3CG 0 0 508 508 1 1
PI3 JAK3 0 0 189 189 1 1
PI3 BCL2L11 0 0 213 213 1 2
PI3 SNX1 0 0 335 335 1 1
PI3 TSC1 0 0 154 153 1 2
PI3 ENSG00000173366 0 0 217 217 1 1
PI3 SERPINA1 0 0 469 500 1 2
PI3 JUN 0 0 391 390 1 2
PI3 TFF3 0 0 142 169 1 1
PI3 LCE1B 0 600 0 600 1 1
PI3 PLCG1 0 0 436 436 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004866 Molecular Function endopeptidase inhibitor activity enables TAS
GO:0004867 Molecular Function serine-type endopeptidase inhibitor activity enables IBA
GO:0030280 Molecular Function structural constituent of skin epidermis enables IDA
GO:0019731 Biological Process antibacterial humoral response involved_in IBA
GO:0007620 Biological Process copulation involved_in IEA
GO:0045087 Biological Process innate immune response involved_in IBA
GO:0018149 Biological Process peptide cross-linking involved_in IDA
GO:0001533 Cellular Component cornified envelope located_in IDA
GO:0001533 Cellular Component cornified envelope located_in TAS
GO:0005829 Cellular Component cytosol located_in TAS
GO:0031012 Cellular Component extracellular matrix located_in TAS
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IBA
Pathways
Name DB ID
Developmental Biology Reactome R-HSA-1266738
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Antimicrobial peptides Reactome R-HSA-6803157
Keratinization Reactome R-HSA-6805567
Formation of the cornified envelope Reactome R-HSA-6809371
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_002638 4 mRNA None NC_000020 Reference