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PKD2

polycystin 2, transient receptor potential cation channel
General Information
Name polycystin 2, transient receptor potential cation channel
Alias
  • polycystin-2
  • autosomal dominant polycystic kidney disease type II protein
  • polycystic kidney disease 2 (autosomal dominant)
  • transient receptor potential cation channel subfamily P member 2
Gene_family EF-hand domain containing|Transient receptor potential cation channels
organism Homo sapiens
entrez_id 5311
location 4q22.1
transcript_count 5
exon_count 16
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
    Stringdb Polycystin-2; Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum. Together with TRPV4, forms mechano- and thermosensitive channels in cilium. PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, to [...]
    nextProt Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
PKD2 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
PKD2 BioGRID CHRND GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CLGN GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID C5AR1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID ART4 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID INSYN1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID IFITM5 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID TMPRSS12 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID LHFPL5 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID OR6T1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CCDC107 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID RNF133 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID DACT3 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID TMC4 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID C15orf32 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID LSMEM2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID FAM3D GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID GRIN3B GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID TPTE2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID TMEM169 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID COG7 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID C3orf52 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CENPH GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID COG6 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID BCAS4 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID ATP6V1D GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CRYL1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID ALG5 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID SPCS1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID PKD2L2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID OR10H1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID FBXO2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID EXOC3 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID C1D GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID PICK1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID NUMB GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID PTGIR GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID PIGH GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID NTSR1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID S1PR1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CYP2J2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CNGA4 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID SEC62 GeneID BioGRID Proximity Label-MS
PKD2 BioGRID RPN2 GeneID BioGRID Proximity Label-MS
PKD2 BioGRID E5 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID E5b GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID E5a GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CYSRT1 GeneID BioGRID Two-hybrid
PKD2 BioGRID KRTAP6-2 GeneID BioGRID Two-hybrid
PKD2 BioGRID HSF2BP GeneID BioGRID Two-hybrid
PKD2 BioGRID MDFI GeneID BioGRID Two-hybrid
PKD2 BioGRID PKD1 GeneID BioGRID Affinity Capture-Western; Co-fractionation; Two-hybrid
PKD2 BioGRID PTPRG GeneID BioGRID Two-hybrid
PKD2 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western
PKD2 BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
PKD2 BioGRID LMNA GeneID BioGRID Two-hybrid
PKD2 BioGRID GCC2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CD300E GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CEP170 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID GLRA2 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID CNGA3 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID Nrip3 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID Kctd5 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID Ppp2r1a GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID Chek1 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID TMEM248 GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID SRPRA GeneID BioGRID Affinity Capture-MS
PKD2 BioGRID MAGEA8 GeneID BioGRID Two-hybrid
PKD2 BioGRID PLSCR1 GeneID BioGRID Two-hybrid
PKD2 BioGRID KRTAP10-3 GeneID BioGRID Two-hybrid
PKD2 BioGRID KRTAP10-8 GeneID BioGRID Two-hybrid
PKD2 BioGRID KRT40 GeneID BioGRID Two-hybrid
PKD2 BioGRID GOLGA2 GeneID BioGRID Co-fractionation
PKD2 BioGRID CANX GeneID BioGRID Co-fractionation
PKD2 BioGRID ATP1A1 GeneID BioGRID Co-fractionation
PKD2 Protein PACS2 GeneID HPRD
PKD2 Protein HAX1 GeneID HPRD
PKD2 Protein TRPC1 GeneID HPRD
PKD2 Protein TNNI3 GeneID HPRD
PKD2 Protein PACS1 GeneID HPRD
PKD2 Protein CD2AP GeneID HPRD
PKD2 Protein DIAPH1 GeneID HPRD
PKD2 Protein PKD1 GeneID HPRD
PKD2 Protein TPM1 GeneID HPRD
PKD2 Protein PKD2 GeneID HPRD
PKD2 Protein ACTN2 GeneID HPRD
PKD2 BioGRID PKD2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
PKD2 BioGRID TNNI3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PKD2 BioGRID TRPC1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PKD2 Protein PKD1 GeneID BIND PKD1 interacts with PKD2.
PKD2 Protein PACS2 GeneID BIND PACS-2 interacts with PKD2.
PKD2 Protein PACS1 GeneID BIND PACS-1 interacts with PKD2.
PKD2 Protein DIAPH1 GeneID BIND PKD2 interacts with DRF1. This interaction was modeled on a demonstrated interaction between human PKD2 and mouse DRF1.
StringDB
A B experiments database textmining combined score hadb nhadb
PKD2 ALB 0 0 218 218 1 2
PKD2 KNG1 0 0 156 155 1 1
PKD2 BBS7 0 0 418 649 1 1
PKD2 TTLL6 0 0 218 283 1 1
PKD2 GPSM1 0 0 171 171 1 1
PKD2 KIF17 0 0 463 463 1 1
PKD2 HERPUD1 0 0 398 486 1 1
PKD2 ARMC4 0 0 81 175 1 1
PKD2 BBS10 0 0 181 208 1 1
PKD2 CUL1 0 0 0 181 1 1
PKD2 RABEP1 0 0 523 523 1 1
PKD2 ENSG00000272822 0 0 0 207 1 1
PKD2 CSNK2A2 0 0 385 414 1 1
PKD2 WNT9B 0 0 241 309 1 1
PKD2 ADCY5 0 0 705 713 1 1
PKD2 HVCN1 0 0 157 241 1 1
PKD2 HNF1B 0 0 392 428 1 1
PKD2 SCT 0 0 151 150 1 1
PKD2 GOLGA4 0 0 386 386 1 1
PKD2 ARL17A 0 0 0 407 1 1
PKD2 MYLK 0 0 97 168 1 1
PKD2 SEC63 0 0 563 689 1 1
PKD2 TRPM4 0 0 631 661 1 1
PKD2 TTLL1 0 0 113 156 1 1
PKD2 GLI2 0 0 251 284 1 2
PKD2 TCTN1 0 0 327 343 1 1
PKD2 RYR1 0 0 388 470 1 2
PKD2 CDH1 0 0 396 396 1 2
PKD2 LEFTY2 0 0 208 226 1 1
PKD2 MACF1 0 0 87 173 1 1
PKD2 CLCN1 0 0 95 151 1 1
PKD2 PKD1L2 0 0 414 665 1 1
PKD2 GLIS2 0 0 143 161 1 1
PKD2 CEP41 0 0 206 238 1 1
PKD2 CALHM3 0 0 0 177 1 1
PKD2 MYOC 0 0 306 306 1 1
PKD2 FJX1 0 0 166 165 1 1
PKD2 AQP2 0 0 416 423 1 1
PKD2 INVS 0 0 606 693 1 1
PKD2 AVP 0 0 154 153 1 1
PKD2 PXN 0 0 157 156 1 1
PKD2 VR1 0 0 559 619 1 1
PKD2 STIM2 0 0 150 339 1 1
PKD2 PTGER4 0 0 306 306 1 1
PKD2 DYNC2H1 0 0 167 223 1 1
PKD2 CTGF 0 0 112 171 1 1
PKD2 P2RX7 0 0 135 167 1 2
PKD2 VANGL2 0 0 310 318 1 1
PKD2 PTK2 0 0 370 370 1 2
PKD2 SCLT1 0 0 125 162 1 1
PKD2 DNAH5 0 0 212 241 1 1
PKD2 TTC21B 0 0 393 551 1 1
PKD2 PDE1C 0 0 112 246 1 1
PKD2 ACTN2 213 0 169 318 1 1
PKD2 IMPDH1 0 0 0 265 1 1
PKD2 DZIP1 0 0 124 235 1 1
PKD2 TRPM8 0 0 505 614 1 1
PKD2 CALCA 0 0 122 176 1 1
PKD2 GGA1 0 0 226 226 1 1
PKD2 EXOC6 0 600 295 772 1 1
PKD2 ITPR1 0 0 963 970 1 2
PKD2 HTR6 0 0 271 316 1 1
PKD2 BLOC1S2 0 0 107 265 1 1
PKD2 ASIC5 0 0 46 235 1 1
PKD2 RAB8B 0 0 0 364 1 2
PKD2 GCC2 169 0 66 209 1 1
PKD2 EGF 0 0 284 284 1 2
PKD2 TMEM2 0 0 259 258 1 1
PKD2 TEK 0 0 170 169 1 1
PKD2 TRPC6 0 0 602 329 1 1
PKD2 NEK9 0 0 518 553 1 1
PKD2 KCNK3 0 0 171 196 1 1
PKD2 NEK8 0 0 774 799 1 1
PKD2 FSCN1 0 0 436 436 1 1
PKD2 TSC1 0 0 227 236 1 2
PKD2 GOLGB1 0 0 143 246 1 1
PKD2 JUN 0 0 160 165 1 2
PKD2 ITPR3 0 0 470 514 1 1
PKD2 NXPH4 0 0 96 152 1 1
PKD2 CNGA1 0 0 154 213 1 1
PKD2 MDFI 75 0 95 364 1 1
PKD2 PLAT 0 0 159 223 1 1
PKD2 OTOP1 0 0 0 222 1 1
PKD2 ARL17B 0 0 0 407 1 1
PKD2 CAV1 0 0 140 183 1 2
PKD2 ALG8 0 0 207 225 1 1
PKD2 GPKOW 0 0 0 463 1 1
PKD2 GPR161 0 0 306 319 1 1
PKD2 MCOLN2 0 0 469 301 1 1
PKD2 EXOC7 0 600 167 657 1 1
PKD2 ITGB1BP2 0 0 0 240 1 1
PKD2 SHCBP1 0 0 0 188 1 1
PKD2 SNX3 0 0 445 445 1 1
PKD2 MCOLN3 0 0 565 334 1 1
PKD2 PKD2L2 129 0 686 166 1 1
PKD2 KCNK17 0 0 62 225 1 1
PKD2 SSTR3 0 0 562 593 1 1
PKD2 NEDD9 0 0 203 213 1 1
PKD2 KRT8 0 0 308 307 1 1
PKD2 OSTF1 0 0 67 432 1 1
PKD2 ID4 0 0 357 357 1 1
PKD2 NBPF1 0 0 404 404 1 1
PKD2 VCP 0 0 0 181 1 2
PKD2 ANK1 0 0 141 227 1 1
PKD2 CPZ 0 0 0 179 1 1
PKD2 DZIP1L 0 0 310 340 1 1
PKD2 IFT52 0 0 375 468 1 1
PKD2 GOLGA2 270 0 253 435 1 1
PKD2 TRPM6 0 0 519 629 1 1
PKD2 ENTPD4 0 0 0 157 1 1
PKD2 SHH 0 0 325 336 1 2
PKD2 RABL2A 0 0 143 196 1 1
PKD2 TRPC5 0 0 615 674 1 1
PKD2 KIF3C 0 0 52 151 1 1
PKD2 P2RY12 0 0 181 181 1 1
PKD2 TRPM5 0 0 450 506 1 1
PKD2 PACRG 0 0 166 165 1 1
PKD2 GPR84 0 0 0 207 1 1
PKD2 PDK2 0 0 161 161 1 1
PKD2 PTGER2 0 0 326 325 1 1
PKD2 GTF3A 0 0 385 384 1 1
PKD2 ZFYVE20 0 0 181 198 1 1
PKD2 SPR 0 0 0 189 1 1
PKD2 CEP164 0 0 324 340 1 1
PKD2 RHOA 0 0 154 161 1 2
PKD2 C2CD3 0 0 170 183 1 1
PKD2 DAND5 0 0 322 336 1 1
PKD2 TNNI3 270 0 454 585 1 1
PKD2 IFT122 0 0 267 317 1 1
PKD2 AURKA 0 0 161 161 1 2
PKD2 WDR19 0 0 289 323 1 1
PKD2 TPM1 213 0 690 752 1 1
PKD2 LRRC46 0 0 0 190 1 1
PKD2 TULP3 0 0 391 390 1 1
PKD2 CPD 0 0 89 183 1 1
PKD2 ACTB 0 0 471 493 1 2
PKD2 TMEM67 0 0 337 369 1 1
PKD2 INS 0 0 181 181 1 2
PKD2 ALG5 296 0 0 296 1 1
PKD2 AGBL3 0 0 0 207 1 1
PKD2 CTTN 0 0 306 306 1 1
PKD2 EXOC3 130 600 284 772 1 1
PKD2 ARL6 0 0 250 250 1 1
PKD2 MAPK3 0 0 174 189 1 2
PKD2 EXOC6B 0 0 125 364 1 1
PKD2 DNAH11 0 0 183 251 1 1
PKD2 GLI3 0 0 266 337 1 1
PKD2 OPN4 0 0 95 192 1 1
PKD2 CALHM1 0 0 0 204 1 1
PKD2 SLC9A3 0 0 149 237 1 1
PKD2 CRCT1 0 0 0 188 1 1
PKD2 EXOC5 0 600 714 929 1 1
PKD2 PKD1L3 0 0 605 445 1 1
PKD2 TMEM17 0 0 261 353 1 1
PKD2 P2RX2 0 0 60 189 1 1
PKD2 ACTN3 0 0 410 410 1 1
PKD2 DCTPP1 0 0 323 326 1 1
PKD2 PANX2 0 0 113 185 1 1
PKD2 CCP110 0 0 181 218 1 1
PKD2 SETBP1 0 0 0 302 1 1
PKD2 PKD1L1 0 0 782 373 1 1
PKD2 HIF1A 0 0 171 171 1 2
PKD2 EDN1 0 0 187 187 1 1
PKD2 WNT7B 0 0 67 171 1 1
PKD2 LRFN5 0 0 0 181 1 1
PKD2 TRPM7 0 0 564 664 1 1
PKD2 BBS1 0 0 464 632 1 1
PKD2 ARF3 0 0 56 219 1 1
PKD2 PAX2 0 0 202 202 1 1
PKD2 KCNJ8 0 0 112 152 1 1
PKD2 ASAP1 0 600 347 773 1 1
PKD2 WNT7A 0 0 57 180 1 1
PKD2 LEFTY1 0 0 134 153 1 1
PKD2 KCNU1 0 0 57 220 1 1
PKD2 TRPV1 0 0 559 619 1 2
PKD2 EXOC8 0 600 234 681 1 1
PKD2 GANAB 0 0 465 465 1 1
PKD2 TMEM44 0 0 0 188 1 1
PKD2 DCAF6 0 0 0 178 1 1
PKD2 MFN2 0 0 123 177 1 2
PKD2 ZNF768 0 0 166 293 1 1
PKD2 CDK2 0 0 350 359 1 2
PKD2 CTNNB1 0 0 463 487 1 2
PKD2 INPP5B 0 0 61 152 1 1
PKD2 CACNA1C 0 0 272 173 1 1
PKD2 ODF2 0 0 218 226 1 1
PKD2 PACS2 213 0 784 824 1 1
PKD2 RAB17 0 0 148 251 1 1
PKD2 KIF3B 0 0 461 518 1 1
PKD2 RHO 0 300 460 621 1 2
PKD2 CBY1 0 0 839 839 1 1
PKD2 NOTCH1 0 0 231 231 1 2
PKD2 PRICKLE1 0 0 66 228 1 1
PKD2 CALM1 0 0 51 203 1 1
PKD2 SMO 0 0 0 381 1 1
PKD2 RPGRIP1L 0 0 363 521 1 1
PKD2 CEP170 223 0 0 223 1 1
PKD2 TRPV6 0 0 546 681 1 1
PKD2 B9D2 0 0 324 326 1 1
PKD2 ANKS3 0 0 269 269 1 1
PKD2 LAP3 0 0 70 152 1 1
PKD2 BBS12 0 0 204 222 1 1
PKD2 MTOR 0 0 391 390 1 2
PKD2 WDR34 0 0 61 155 1 1
PKD2 CTRL 0 0 0 161 1 2
PKD2 BICC1 0 0 175 278 1 1
PKD2 MROH2A 0 0 0 180 1 1
PKD2 POLR1D 0 0 91 172 1 1
PKD2 KCNMA1 0 0 212 228 1 1
PKD2 ACTN4 0 0 504 504 1 1
PKD2 NPHS1 0 0 214 214 1 1
PKD2 STAT1 0 0 175 175 1 2
PKD2 ARL3 0 0 459 664 1 1
PKD2 ADCY9 0 0 125 205 1 1
PKD2 ARF1 0 0 112 265 1 1
PKD2 TPCN2 0 0 277 277 1 1
PKD2 PANX3 0 0 123 219 1 1
PKD2 RYR2 0 0 895 913 1 1
PKD2 HAVCR1 0 0 667 667 1 1
PKD2 CLUAP1 0 0 171 201 1 1
PKD2 PIEZO2 0 0 390 524 1 1
PKD2 ENTPD7 0 0 0 286 1 1
PKD2 PLCG2 0 0 212 286 1 1
PKD2 TAS2R9 0 0 0 298 1 1
PKD2 TTC30B 0 0 288 318 1 1
PKD2 RAPGEF3 0 0 175 175 1 1
PKD2 RAPGEF4 0 0 185 185 1 1
PKD2 MGMT 0 0 0 193 1 2
PKD2 TRPC1 486 0 988 994 1 1
PKD2 PDE4C 0 0 629 629 1 1
PKD2 RYR3 0 0 167 278 1 1
PKD2 FTO 0 0 0 183 1 2
PKD2 WNT8A 0 0 57 237 1 1
PKD2 BCAS4 271 0 0 271 1 1
PKD2 MAGEA8 289 0 0 288 1 1
PKD2 DIAPH1 481 0 171 605 1 1
PKD2 ITPR2 0 0 233 296 1 1
PKD2 CALCR 0 0 65 226 1 1
PKD2 UMOD 0 0 241 240 1 1
PKD2 IFT81 0 0 323 507 1 1
PKD2 TPCN1 0 0 113 168 1 1
PKD2 BBS4 0 0 470 629 1 1
PKD2 TRAF3IP1 0 0 294 402 1 1
PKD2 KCNK1 0 0 75 169 1 1
PKD2 GAPDH 0 0 202 202 1 2
PKD2 TRPC3 0 0 688 369 1 1
PKD2 MAP2K7 0 0 231 230 1 1
PKD2 WNT5A 0 0 96 152 1 2
PKD2 IFT22 0 0 244 276 1 1
PKD2 IFT20 0 0 662 836 1 1
PKD2 MYC 0 0 245 244 1 2
PKD2 GPR151 0 0 0 211 1 1
PKD2 RFX2 0 0 107 160 1 1
PKD2 PFN4 0 0 0 190 1 1
PKD2 NPHP4 0 0 392 603 1 1
PKD2 GNAQ 0 0 155 162 1 1
PKD2 DVL1 0 0 123 160 1 1
PKD2 OFD1 0 0 424 424 1 2
PKD2 GNAT3 0 0 0 402 1 1
PKD2 TBC1D31 0 0 0 161 1 1
PKD2 MICU1 0 0 154 251 1 1
PKD2 PLCB2 0 0 0 188 1 1
PKD2 WWTR1 0 0 792 826 1 1
PKD2 GNAT2 0 0 0 190 1 1
PKD2 CEP83 0 0 212 236 1 1
PKD2 FLNA 0 0 445 445 1 1
PKD2 ANO1 0 0 213 294 1 1
PKD2 GOLPH3 0 0 181 181 1 1
PKD2 TCTN2 0 0 205 205 1 1
PKD2 CEP97 0 0 203 232 1 1
PKD2 CPN1 0 0 0 341 1 1
PKD2 BBS2 0 0 391 557 1 1
PKD2 GLRA2 273 0 0 273 1 1
PKD2 PCNT 0 0 495 527 1 1
PKD2 AQP1 0 0 194 194 1 1
PKD2 TCF3 0 0 0 181 1 1
PKD2 CNGB1 0 500 368 699 1 1
PKD2 DSP 0 0 279 279 1 1
PKD2 STK11 0 0 244 243 1 2
PKD2 FLNB 0 0 55 232 1 1
PKD2 CFTR 0 0 455 455 1 2
PKD2 PKHD1 0 0 981 981 1 1
PKD2 STX5 0 0 462 462 1 1
PKD2 TMEM33 0 0 113 279 1 1
PKD2 EGFR 0 0 231 230 1 2
PKD2 LHX1 0 0 131 163 1 1
PKD2 AGBL1 0 0 0 207 1 1
PKD2 AAAS 0 0 154 168 1 1
PKD2 PITX2 0 0 213 295 1 1
PKD2 P2RX4 0 0 150 163 1 1
PKD2 ORAI1 0 0 267 282 1 1
PKD2 WNT4 0 0 95 151 1 1
PKD2 HSPB11 0 0 341 356 1 1
PKD2 GNAT1 0 0 0 190 1 1
PKD2 EXOC2 0 600 181 671 1 1
PKD2 HDAC6 0 0 459 459 1 2
PKD2 SCNN1B 0 0 0 189 1 1
PKD2 DNTTIP1 0 0 0 303 1 1
PKD2 PLEKHA8 0 0 182 183 1 1
PKD2 JAK2 0 0 142 160 1 2
PKD2 DAW1 0 0 150 173 1 1
PKD2 RPGR 0 0 285 302 1 1
PKD2 CALM3 0 0 55 206 1 1
PKD2 RAB8A 0 600 466 852 1 2
PKD2 MCOLN1 0 0 622 703 1 2
PKD2 MYO7B 0 0 104 168 1 1
PKD2 INPP5E 0 0 143 165 1 1
PKD2 OCRL 0 0 233 399 1 1
PKD2 IMPDH2 0 0 0 265 1 1
PKD2 SCNN1G 0 0 0 210 1 1
PKD2 STAT3 0 0 167 224 1 2
PKD2 MKKS 0 0 69 163 1 1
PKD2 FFAR4 0 0 0 188 1 1
PKD2 STOML3 0 0 269 336 1 1
PKD2 AGBL4 0 0 181 326 1 1
PKD2 VEGFA 0 0 202 202 1 2
PKD2 TRPV3 0 0 459 496 1 1
PKD2 PKD1P1 0 0 381 381 1 1
PKD2 GPR68 0 0 70 212 1 1
PKD2 LZTFL1 0 0 142 202 1 1
PKD2 IFT46 0 0 310 372 1 1
PKD2 CCDC115 0 0 134 225 1 1
PKD2 CCDC114 0 0 113 202 1 1
PKD2 C21orf33 0 0 195 195 1 1
PKD2 SDCCAG3 0 0 138 466 1 1
PKD2 PRKG2 0 0 0 187 1 1
PKD2 STX3 0 0 142 234 1 1
PKD2 PTPRG 192 0 392 501 1 1
PKD2 WT1 0 0 102 158 1 1
PKD2 NPHP3 0 0 492 536 1 1
PKD2 CEP89 0 0 213 235 1 1
PKD2 KCNA2 0 0 151 157 1 1
PKD2 KCNK2 0 0 281 306 1 1
PKD2 M6PR 0 0 320 319 1 1
PKD2 TNPO1 0 0 214 214 1 1
PKD2 EXOC4 0 600 324 746 1 1
PKD2 CNTLN 0 0 230 229 1 1
PKD2 PKDREJ 0 0 553 275 1 1
PKD2 PFN2 0 0 0 189 1 1
PKD2 PIEZO1 0 0 504 642 1 1
PKD2 FMN1 0 0 408 421 1 1
PKD2 KCNK4 0 0 138 271 1 1
PKD2 DYNC2LI1 0 0 113 194 1 1
PKD2 TAC1 0 0 459 459 1 1
PKD2 EGLN2 0 0 0 189 1 1
PKD2 TJP1 0 0 184 201 1 1
PKD2 CNGA4 0 500 142 593 1 1
PKD2 CALCRL 0 0 0 207 1 1
PKD2 KPTN 0 0 0 224 1 1
PKD2 GLI1 0 0 265 279 1 2
PKD2 ARL13B 0 0 596 638 1 1
PKD2 KCNN4 0 0 159 158 1 1
PKD2 HERPUD2 0 0 0 333 1 1
PKD2 PACSIN3 0 0 269 282 1 1
PKD2 VAMP3 0 0 270 270 1 1
PKD2 BBS9 0 0 244 500 1 1
PKD2 FN1 0 0 185 208 1 2
PKD2 CASR 0 0 234 247 1 2
PKD2 IFT27 0 0 419 482 1 1
PKD2 COCH 0 0 73 325 1 1
PKD2 RAB11FIP3 0 600 74 613 1 1
PKD2 IFT74 0 0 320 541 1 1
PKD2 VWDE 0 0 0 175 1 1
PKD2 ALDH4A1 0 0 0 256 1 1
PKD2 PRKCA 0 0 151 150 1 1
PKD2 ADCY8 0 0 166 180 1 1
PKD2 AVPR2 0 0 518 527 1 1
PKD2 OPTN 0 0 716 716 1 2
PKD2 P2RY2 0 0 202 202 1 1
PKD2 TRPA1 0 0 520 334 1 1
PKD2 IFT80 0 0 324 366 1 1
PKD2 KIAA0586 0 0 209 235 1 1
PKD2 BBS5 0 0 401 640 1 1
PKD2 NOX1 0 0 0 208 1 1
PKD2 KIF3A 0 0 836 853 1 1
PKD2 ENSG00000256349 0 0 0 342 1 1
PKD2 YAP1 0 0 101 163 1 2
PKD2 PRKD1 0 0 715 733 1 1
PKD2 HYDIN 0 0 171 178 1 1
PKD2 WNT3A 0 0 150 213 1 2
PKD2 ATP1A1 270 0 0 270 1 1
PKD2 MCHR1 0 0 421 437 1 1
PKD2 FRMD6 0 0 389 404 1 1
PKD2 SCD5 0 0 0 195 1 1
PKD2 TTLL4 0 0 166 184 1 1
PKD2 GLIS3 0 0 86 226 1 1
PKD2 PCDHGC5 0 0 0 331 1 1
PKD2 ADCY3 0 0 267 279 1 1
PKD2 EVC2 0 0 132 173 1 1
PKD2 SNAPIN 0 0 181 519 1 1
PKD2 ARF6 0 0 150 203 1 1
PKD2 IFT57 0 0 438 499 1 1
PKD2 PRKCSH 0 0 724 752 1 1
PKD2 MICU3 0 0 123 258 1 1
PKD2 BECN1 0 0 670 670 1 2
PKD2 PICK1 224 0 0 224 1 1
PKD2 ORAI3 0 0 173 260 1 1
PKD2 AGBL5 0 0 195 226 1 1
PKD2 LRP2 0 0 157 156 1 1
PKD2 WDR35 0 0 195 210 1 1
PKD2 BTRC 0 0 95 228 1 1
PKD2 HAX1 192 0 935 945 1 1
PKD2 NIN 0 0 150 172 1 1
PKD2 LIN54 0 0 0 160 1 1
PKD2 GPBAR1 0 0 161 161 1 1
PKD2 NPHP1 0 0 457 605 1 1
PKD2 TMEM248 246 0 0 245 1 1
PKD2 PTH 0 0 142 164 1 1
PKD2 TPTE2 189 0 0 189 1 1
PKD2 TMEM231 0 0 253 281 1 1
PKD2 CNGA3 129 0 134 261 1 1
PKD2 DTNBP1 0 0 113 162 1 1
PKD2 KCNK18 0 0 167 241 1 1
PKD2 SCNN1A 0 0 0 189 1 1
PKD2 KCNK10 0 0 141 273 1 1
PKD2 CYS1 0 0 457 457 1 1
PKD2 PLA2G2C 0 0 0 212 1 1
PKD2 MNS1 0 0 92 198 1 1
PKD2 FAM3D 411 0 0 410 1 1
PKD2 KCNJ10 0 0 141 178 1 1
PKD2 SCRIB 0 0 57 158 1 1
PKD2 AKAP1 0 0 211 211 1 1
PKD2 IQCB1 0 0 370 378 1 1
PKD2 GOLGA1 0 0 166 165 1 1
PKD2 TRPV5 0 0 556 688 1 1
PKD2 POC1A 0 0 134 153 1 1
PKD2 KCNK16 0 0 123 269 1 1
PKD2 CALHM2 0 0 0 173 1 1
PKD2 PDE1A 0 0 194 260 1 1
PKD2 FAT4 0 0 181 251 1 1
PKD2 CALM2 0 0 0 194 1 1
PKD2 SST 0 0 321 321 1 1
PKD2 NUDT9 0 0 140 193 1 1
PKD2 UNC119 0 0 155 193 1 1
PKD2 KLF2 0 0 181 322 1 1
PKD2 TRPM3 0 0 503 617 1 1
PKD2 STAM 0 0 193 283 1 1
PKD2 PFN1 0 0 0 173 1 1
PKD2 REN 0 0 306 306 1 1
PKD2 ACE 0 0 252 252 1 1
PKD2 KIF2A 0 0 94 220 1 1
PKD2 HELLS 0 0 0 208 1 1
PKD2 TRPC4 0 0 717 747 1 1
PKD2 GRM1 0 0 350 349 1 1
PKD2 CC2D2A 0 0 391 467 1 1
PKD2 HNRNPL 270 0 0 270 1 1
PKD2 TRPM2 0 0 414 548 1 2
PKD2 CEP19 0 0 172 171 1 1
PKD2 SEPT2 0 0 299 326 1 1
PKD2 CASP3 0 0 134 157 1 2
PKD2 MKS1 0 0 392 396 1 1
PKD2 RAB11A 0 600 339 753 1 2
PKD2 RAC2 0 0 157 158 1 1
PKD2 CCDC109B 0 0 147 416 1 1
PKD2 PACSIN1 0 0 61 161 1 1
PKD2 KDR 0 0 181 198 1 2
PKD2 EIF2S1 0 0 154 153 1 2
PKD2 ADCY4 0 0 180 220 1 1
PKD2 TGOLN2 0 0 323 323 1 1
PKD2 TRIP11 0 0 455 519 1 1
PKD2 TRPV4 0 0 989 991 1 1
PKD2 PGP 0 0 307 307 1 1
PKD2 MCIDAS 0 0 141 159 1 1
PKD2 CLCN7 0 0 181 198 1 1
PKD2 IFT88 0 0 634 785 1 1
PKD2 TAS2R13 0 0 0 193 1 1
PKD2 VPS45 0 0 90 152 1 1
PKD2 RAB28 0 0 113 153 1 1
PKD2 TSC2 0 0 359 412 1 2
PKD2 PIK3C2A 0 0 325 325 1 1
PKD2 PODXL 0 0 205 205 1 1
PKD2 CCNO 0 0 74 157 1 1
PKD2 SCD 0 0 0 195 1 1
PKD2 SRC 0 0 272 272 1 2
PKD2 ORAI2 0 0 68 167 1 1
PKD2 DOCK2 0 0 45 162 1 1
PKD2 CEP162 0 0 208 440 1 1
PKD2 ENSG00000279890 0 0 417 339 1 1
PKD2 MCU 0 0 244 291 1 2
PKD2 NEXN 0 0 329 329 1 1
PKD2 ARMC3 0 0 0 189 1 1
PKD2 NEK1 0 0 340 356 1 1
PKD2 RABEP2 0 0 108 182 1 1
PKD2 TRPV2 0 0 594 638 1 1
PKD2 EIF2AK3 0 0 158 164 1 2
PKD2 STAT6 0 0 261 262 1 1
PKD2 DNAJB11 0 0 161 161 1 1
PKD2 RHBDD3 0 0 0 193 1 1
PKD2 PLSCR1 274 0 0 274 1 1
PKD2 PKD1 978 540 990 994 1 1
PKD2 CCDC135 0 0 135 184 1 1
PKD2 PSMD7 0 0 0 181 1 1
PKD2 FBXW11 0 0 0 158 1 1
PKD2 SYCN 0 0 95 183 1 1
PKD2 ANK3 0 0 66 197 1 1
PKD2 EIF4EBP1 0 0 161 161 1 2
PKD2 KRT18 0 0 310 309 1 1
PKD2 PKHD1L1 0 0 280 295 1 1
PKD2 ID2 270 0 952 967 1 1
PKD2 GJA1 0 0 136 175 1 1
PKD2 SLC12A1 0 0 137 162 1 1
PKD2 ARL13A 0 0 370 424 1 1
PKD2 TAS1R1 0 0 0 396 1 1
PKD2 FBF1 0 0 181 181 1 1
PKD2 FOXJ1 0 0 181 218 1 1
PKD2 TTC21A 0 0 0 292 1 1
PKD2 KCNJ1 0 0 142 157 1 1
PKD2 TMEM216 0 0 211 220 1 1
PKD2 CPE 0 0 0 179 1 1
PKD2 BBIP1 0 0 258 258 1 1
PKD2 B9D1 0 0 321 401 1 1
PKD2 WDTC1 0 0 0 178 1 1
PKD2 PPARG 0 0 108 150 1 2
PKD2 ARL5A 0 0 0 242 1 1
PKD2 AKT1 270 0 294 470 1 2
PKD2 ACKR1 0 0 0 190 1 1
PKD2 ARF4 0 600 716 884 1 1
PKD2 ANKS6 0 0 325 326 1 1
PKD2 RUNX2 0 0 155 154 1 2
PKD2 IFT172 0 0 398 461 1 1
PKD2 PDE6D 0 0 215 215 1 1
PKD2 AHI1 0 0 310 336 1 1
PKD2 PANX1 0 0 217 238 1 1
PKD2 SKI 0 0 208 225 1 1
PKD2 ADCY6 0 0 663 676 1 1
PKD2 NFAT5 0 0 63 177 1 1
PKD2 UNC119B 0 0 150 188 1 1
PKD2 ASIC2 0 0 183 184 1 1
PKD2 TRPM1 0 0 517 627 1 1
PKD2 DNAH9 0 0 108 182 1 1
PKD2 ADCY7 0 0 134 176 1 1
PKD2 IFT140 0 0 408 499 1 1
PKD2 VCL 0 0 150 167 1 1
PKD2 GPR4 0 0 0 188 1 1
PKD2 CNGA2 0 500 163 594 1 1
PKD2 ALDH7A1 0 0 195 195 1 1
PKD2 BCAP31 161 0 397 472 1 1
PKD2 TAS1R2 0 0 48 437 1 1
PKD2 CSNK2A1 0 0 412 440 1 1
PKD2 C1orf27 0 0 182 182 1 1
PKD2 PPP6R3 0 0 0 359 1 1
PKD2 CD2AP 213 0 376 546 1 1
PKD2 PTCH1 0 0 207 261 1 1
PKD2 AGTPBP1 0 0 0 207 1 1
PKD2 ANAPC2 0 0 435 435 1 1
PKD2 RAB23 0 0 228 233 1 2
PKD2 RFX3 0 0 154 170 1 1
PKD2 EXOC3L2 0 0 0 200 1 1
PKD2 TTLL11 0 0 180 198 1 1
PKD2 RDH8 0 0 113 186 1 1
PKD2 CEP290 0 0 504 549 1 1
PKD2 IFT43 0 0 151 172 1 1
PKD2 TMEM27 0 0 138 175 1 1
PKD2 ASIC1 0 0 112 265 1 2
PKD2 SCAI 0 0 46 168 1 1
PKD2 HYLS1 0 0 151 151 1 1
PKD2 CNGB3 0 0 81 162 1 1
PKD2 LYZL6 0 0 154 154 1 1
PKD2 SRPR 218 0 0 218 1 1
PKD2 HOXB7 0 0 155 211 1 1
PKD2 GATD3B 0 0 203 203 1 1
PKD2 KCNK9 0 0 103 201 1 1
PKD2 KXD1 0 0 170 396 1 1
PKD2 NOS3 0 0 212 212 1 2
PKD2 RCC1 0 0 166 165 1 1
PKD2 AKAP5 0 0 73 174 1 1
PKD2 ANO7 0 0 0 192 1 1
PKD2 ACTN1 0 0 306 306 1 1
PKD2 DVL2 0 0 171 235 1 2
PKD2 STIM1 0 0 446 569 1 2
PKD2 WNT9A 0 0 81 156 1 1
PKD2 WNT8B 0 0 49 230 1 1
PKD2 EXOC1 0 600 242 703 1 1
PKD2 RHEB 0 0 184 183 1 2
PKD2 BCAT2 0 0 337 337 1 1
PKD2 MICU2 0 0 136 269 1 1
PKD2 AGBL2 0 0 65 226 1 1
PKD2 CROCC 0 0 82 201 1 1
PKD2 KIF12 0 0 103 159 1 1
PKD2 ATP2A2 0 0 123 157 1 1
PKD2 PACS1 213 0 917 934 1 1
PKD2 SEMA4G 0 0 0 341 1 1
PKD2 SV2B 0 0 0 204 1 1
PKD2 ANK2 0 0 0 175 1 1
PKD2 RAB3IP 0 600 452 778 1 1
PKD2 AQP11 0 0 155 161 1 1
PKD2 INF2 0 0 46 216 1 1
PKD2 ALMS1 0 0 216 224 1 1
PKD2 TMEM212 0 0 0 298 1 1
PKD2 CANX 270 0 258 439 1 2
PKD2 NPHS2 0 0 219 333 1 2
PKD2 ENSG00000264813 0 0 235 235 1 1
PKD2 INADL 0 0 392 392 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0051117 Molecular Function ATPase binding enables ISS
GO:0043398 Molecular Function HLH domain binding enables IPI
GO:0042805 Molecular Function actinin binding enables IDA
GO:0005262 Molecular Function calcium channel activity contributes_to IDA
GO:0005509 Molecular Function calcium ion binding enables IBA
GO:0005509 Molecular Function calcium ion binding enables IDA
GO:0005509 Molecular Function calcium ion binding enables ISS
GO:0048763 Molecular Function calcium-induced calcium release activity enables IDA
GO:0008092 Molecular Function cytoskeletal protein binding enables IDA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0042802 Molecular Function identical protein binding enables ISS
GO:0005261 Molecular Function monoatomic cation channel activity enables IMP
GO:0051371 Molecular Function muscle alpha-actinin binding enables IBA
GO:0015271 Molecular Function outward rectifier potassium channel activity enables ISS
GO:0051219 Molecular Function phosphoprotein binding enables IPI
GO:0005267 Molecular Function potassium channel activity enables IBA
GO:0005267 Molecular Function potassium channel activity enables IDA
GO:0005267 Molecular Function potassium channel activity enables ISS
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0005102 Molecular Function signaling receptor binding enables IBA
GO:0005102 Molecular Function signaling receptor binding enables IPI
GO:0140416 Molecular Function transcription regulator inhibitor activity enables IPI
GO:0044325 Molecular Function transmembrane transporter binding enables IPI
GO:0005245 Molecular Function voltage-gated calcium channel activity enables IBA
GO:0005245 Molecular Function voltage-gated calcium channel activity enables IDA
GO:0022843 Molecular Function voltage-gated monoatomic cation channel activity enables IDA
GO:0005244 Molecular Function voltage-gated monoatomic ion channel activity enables IDA
GO:0005249 Molecular Function voltage-gated potassium channel activity enables IMP
GO:0005248 Molecular Function voltage-gated sodium channel activity enables IBA
GO:0005248 Molecular Function voltage-gated sodium channel activity enables IDA
GO:0005248 Molecular Function voltage-gated sodium channel activity enables IMP
GO:0016055 Biological Process Wnt signaling pathway involved_in IEA
GO:0035904 Biological Process aorta development involved_in IEP
GO:0001658 Biological Process branching involved in ureteric bud morphogenesis involved_in IEP
GO:0070588 Biological Process calcium ion transmembrane transport involved_in IDA
GO:0006816 Biological Process calcium ion transport involved_in IDA
GO:0006816 Biological Process calcium ion transport involved_in ISS
GO:0198738 Biological Process cell-cell signaling by wnt involved_in IDA
GO:0071320 Biological Process cellular response to cAMP involved_in IMP
GO:0071277 Biological Process cellular response to calcium ion involved_in ISS
GO:0071498 Biological Process cellular response to fluid shear stress involved_in IMP
GO:0071464 Biological Process cellular response to hydrostatic pressure involved_in IDA
GO:0071470 Biological Process cellular response to osmotic stress involved_in IDA
GO:0034614 Biological Process cellular response to reactive oxygen species involved_in NAS
GO:0051298 Biological Process centrosome duplication involved_in NAS
GO:0044782 Biological Process cilium organization acts_upstream_of_or_within IMP
GO:0050982 Biological Process detection of mechanical stimulus involved_in IBA
GO:0050982 Biological Process detection of mechanical stimulus involved_in ISS
GO:0003127 Biological Process detection of nodal flow involved_in ISS
GO:0007368 Biological Process determination of left/right symmetry involved_in ISS
GO:0071910 Biological Process determination of liver left/right asymmetry involved_in IMP
GO:0001892 Biological Process embryonic placenta development involved_in ISS
GO:0051649 Biological Process establishment of localization in cell involved_in IEA
GO:0007507 Biological Process heart development involved_in IEP
GO:0001947 Biological Process heart looping involved_in IMP
GO:0098662 Biological Process inorganic cation transmembrane transport involved_in IMP
GO:0006874 Biological Process intracellular calcium ion homeostasis involved_in IEA
GO:0001889 Biological Process liver development involved_in IEP
GO:0072177 Biological Process mesonephric duct development involved_in IEP
GO:0072164 Biological Process mesonephric tubule development involved_in IEP
GO:0072284 Biological Process metanephric S-shaped body morphogenesis involved_in IEP
GO:0072218 Biological Process metanephric ascending thin limb development involved_in IEP
GO:0072214 Biological Process metanephric cortex development involved_in IEP
GO:0072219 Biological Process metanephric cortical collecting duct development involved_in IEP
GO:0072235 Biological Process metanephric distal tubule development involved_in IEP
GO:0072075 Biological Process metanephric mesenchyme development involved_in IEP
GO:0035502 Biological Process metanephric part of ureteric bud development involved_in IEP
GO:0072208 Biological Process metanephric smooth muscle tissue development involved_in IEP
GO:2000134 Biological Process negative regulation of G1/S transition of mitotic cell cycle acts_upstream_of IMP
GO:0008285 Biological Process negative regulation of cell population proliferation involved_in NAS
GO:0060315 Biological Process negative regulation of ryanodine-sensitive calcium-release channel activity involved_in ISS
GO:0021915 Biological Process neural tube development involved_in IEP
GO:0060674 Biological Process placenta blood vessel development involved_in ISS
GO:0007204 Biological Process positive regulation of cytosolic calcium ion concentration involved_in IEA
GO:0010628 Biological Process positive regulation of gene expression involved_in IEA
GO:0031587 Biological Process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity involved_in IMP
GO:0045429 Biological Process positive regulation of nitric oxide biosynthetic process involved_in IMP
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IMP
GO:0071805 Biological Process potassium ion transmembrane transport involved_in IBA
GO:0071805 Biological Process potassium ion transmembrane transport involved_in IDA
GO:0071805 Biological Process potassium ion transmembrane transport involved_in IMP
GO:0071805 Biological Process potassium ion transmembrane transport involved_in ISS
GO:0051290 Biological Process protein heterotetramerization involved_in IDA
GO:0051289 Biological Process protein homotetramerization involved_in IDA
GO:0051262 Biological Process protein tetramerization involved_in IDA
GO:0007259 Biological Process receptor signaling pathway via JAK-STAT involved_in ISO
GO:0007259 Biological Process receptor signaling pathway via JAK-STAT involved_in ISS
GO:0090279 Biological Process regulation of calcium ion import involved_in IDA
GO:0051726 Biological Process regulation of cell cycle involved_in ISS
GO:0042127 Biological Process regulation of cell population proliferation involved_in IMP
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IBA
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IDA
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IMP
GO:0061441 Biological Process renal artery morphogenesis involved_in IEP
GO:0061333 Biological Process renal tubule morphogenesis involved_in ISS
GO:0035725 Biological Process sodium ion transmembrane transport involved_in IDA
GO:0035725 Biological Process sodium ion transmembrane transport involved_in IMP
GO:0021510 Biological Process spinal cord development involved_in IEP
GO:0005794 Cellular Component Golgi apparatus located_in ISS
GO:0045180 Cellular Component basal cortex located_in IDA
GO:0009925 Cellular Component basal plasma membrane located_in IDA
GO:0016323 Cellular Component basolateral plasma membrane located_in IEA
GO:0034703 Cellular Component cation channel complex part_of IDA
GO:0005911 Cellular Component cell-cell junction colocalizes_with ISS
GO:0036064 Cellular Component ciliary basal body located_in IDA
GO:0060170 Cellular Component ciliary membrane located_in IEA
GO:0005929 Cellular Component cilium located_in IDA
GO:0005929 Cellular Component cilium located_in ISO
GO:0005929 Cellular Component cilium located_in ISS
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IMP
GO:0098554 Cellular Component cytoplasmic side of endoplasmic reticulum membrane located_in IDA
GO:0030659 Cellular Component cytoplasmic vesicle membrane located_in IEA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0005783 Cellular Component endoplasmic reticulum located_in IMP
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IDA
GO:0070062 Cellular Component extracellular exosome located_in HDA
GO:0030027 Cellular Component lamellipodium located_in IDA
GO:0098553 Cellular Component lumenal side of endoplasmic reticulum membrane located_in IDA
GO:0016020 Cellular Component membrane is_active_in IBA
GO:0016020 Cellular Component membrane located_in IDA
GO:0072686 Cellular Component mitotic spindle located_in IDA
GO:0031514 Cellular Component motile cilium located_in ISS
GO:0097730 Cellular Component non-motile cilium located_in ISS
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IMP
GO:0002133 Cellular Component polycystin complex part_of IPI
GO:0002133 Cellular Component polycystin complex part_of ISS
Pathways
Name DB ID
Organelle biogenesis and maintenance Reactome R-HSA-1852241
Cilium Assembly Reactome R-HSA-5617833
VxPx cargo-targeting to cilium Reactome R-HSA-5620916
Cargo trafficking to the periciliary membrane Reactome R-HSA-5620920
Ciliopathies (WP4803) WikiPathways WP4803_r110008
Bardet-Biedl syndrome (WP5234) WikiPathways WP5234_r123515
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_156488 2 miscRNA transcript variant 2 NC_000004 Reference
NM_000297 4 mRNA transcript variant 1 NC_000004 Reference
XM_011532028 3 mRNA transcript variant X1 NC_000004 Reference
XM_011532029 2 mRNA transcript variant X2 NC_000004 Reference
XM_011532030 3 mRNA transcript variant X3 NC_000004 Reference