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DDIT4

DNA damage inducible transcript 4
General Information
Name DNA damage inducible transcript 4
Alias
  • DNA damage-inducible transcript 4 protein
  • HIF-1 responsive protein RTP801
  • protein regulated in development and DNA damage response 1
Gene_family
organism Homo sapiens
entrez_id 54541
location 10q22.1
transcript_count 1
exon_count 3
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Predicted to enable 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR signaling; and response to hypoxia. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell typ [...]
    nextProt Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
DDIT4 BioGRID DCAF6 GeneID BioGRID Affinity Capture-MS
DDIT4 BioGRID CUL4A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
DDIT4 BioGRID N GeneID BioGRID Protein-RNA
DDIT4 BioGRID NME2P1 GeneID BioGRID Affinity Capture-MS
DDIT4 BioGRID HUWE1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DDIT4 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
DDIT4 BioGRID EGFR GeneID BioGRID Positive Genetic
DDIT4 BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-RNA
DDIT4 BioGRID DCAF15 GeneID BioGRID Proximity Label-MS
DDIT4 BioGRID LRRK2 GeneID BioGRID Reconstituted Complex
DDIT4 BioGRID NEDD4 GeneID BioGRID Affinity Capture-Western
DDIT4 BioGRID HSPB2 GeneID BioGRID Two-hybrid
DDIT4 BioGRID YWHAB GeneID BioGRID Affinity Capture-Western
DDIT4 BioGRID TXNIP GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
DDIT4 BioGRID YWHAZ GeneID BioGRID Affinity Capture-Western
DDIT4 BioGRID PRKN GeneID BioGRID Affinity Capture-Western; Biochemical Activity
DDIT4 BioGRID BTRC GeneID BioGRID Affinity Capture-Western
DDIT4 BioGRID GSK3B GeneID BioGRID Affinity Capture-Western; Biochemical Activity
DDIT4 BioGRID DDB1 GeneID BioGRID Affinity Capture-Western
DDIT4 BioGRID HSPA4 GeneID BioGRID Two-hybrid
DDIT4 BioGRID PDPK1 GeneID BioGRID Two-hybrid
DDIT4 None LRIF1 GeneID HPRD
DDIT4 None HSPA4 GeneID HPRD
DDIT4 BioGRID LRIF1 GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
DDIT4 HTT 0 0 194 199 1 2
DDIT4 EGFR 0 0 250 256 1 2
DDIT4 CDK4 0 0 150 182 1 2
DDIT4 SLC2A1 0 0 416 441 1 2
DDIT4 NEDD8 0 0 155 154 1 2
DDIT4 FOXS1 0 0 63 161 1 1
DDIT4 RASGRP1 0 0 62 151 1 1
DDIT4 HMBS 0 0 94 190 1 1
DDIT4 COMMD8 0 0 0 218 1 1
DDIT4 RAB2A 0 0 0 250 1 1
DDIT4 TGM2 0 0 270 270 1 2
DDIT4 LCN2 0 0 112 162 1 1
DDIT4 TP53 0 900 604 958 1 2
DDIT4 MDM2 0 0 303 303 1 2
DDIT4 BCAS3 0 0 105 160 1 1
DDIT4 EDA 0 0 0 642 1 1
DDIT4 SLC7A5 0 0 270 302 1 1
DDIT4 DDIT3 0 0 459 468 1 2
DDIT4 PLOD1 0 0 205 205 1 1
DDIT4 MXD4 0 0 66 204 1 1
DDIT4 HK2 0 0 218 265 1 2
DDIT4 CUL2 0 0 155 154 1 1
DDIT4 SIAH2 0 0 113 168 1 1
DDIT4 NPRL2 0 0 155 154 1 1
DDIT4 LY86 0 0 88 155 1 1
DDIT4 NR4A1 0 0 143 295 1 2
DDIT4 BMP2K 0 0 61 163 1 1
DDIT4 HUWE1 270 0 203 406 1 1
DDIT4 CAMKK2 0 0 358 358 1 2
DDIT4 MKNK1 0 0 107 172 1 1
DDIT4 TSC22D3 0 0 395 448 1 1
DDIT4 MRPL42 0 0 81 235 1 1
DDIT4 C7orf60 0 0 166 165 1 1
DDIT4 STAT3 0 0 293 293 1 2
DDIT4 TCEB3CL2 0 0 0 323 1 1
DDIT4 GDNF 0 0 143 161 1 2
DDIT4 EIF2AK4 0 0 317 317 1 2
DDIT4 LAMTOR4 0 0 162 161 1 1
DDIT4 TAOK2 0 0 54 227 1 1
DDIT4 NDUFS1 0 0 61 159 1 1
DDIT4 SFT2D2 0 0 125 184 1 1
DDIT4 EDN2 0 0 117 160 1 1
DDIT4 ERN1 0 0 244 260 1 2
DDIT4 PCK1 0 0 134 172 1 1
DDIT4 PPARGC1A 0 0 293 293 1 2
DDIT4 IGF1R 0 0 285 285 1 2
DDIT4 PARK2 270 0 210 398 1 1
DDIT4 NR0B2 0 0 0 208 1 1
DDIT4 MAD2L1 0 0 0 189 1 1
DDIT4 MYC 0 0 342 357 1 2
DDIT4 ITGAE 0 0 306 306 1 1
DDIT4 PDK1 0 0 321 321 1 2
DDIT4 IFITM3 0 0 123 163 1 1
DDIT4 IDH3G 0 0 60 154 1 1
DDIT4 ZNF812 0 0 216 216 1 1
DDIT4 PIK3CA 0 0 203 203 1 2
DDIT4 TPI1 0 0 143 184 1 1
DDIT4 TIGD4 0 0 135 231 1 1
DDIT4 EMC4 0 0 81 282 1 1
DDIT4 NDUFC1 0 0 0 196 1 1
DDIT4 PIK3R3 0 0 142 238 1 1
DDIT4 ADORA1 0 0 77 215 1 1
DDIT4 EGLN3 0 0 391 441 1 1
DDIT4 MAATS1 0 0 45 150 1 1
DDIT4 RPL27 0 0 97 161 1 1
DDIT4 HNRNPUL1 0 0 103 176 1 1
DDIT4 RICTOR 0 0 492 495 1 2
DDIT4 EFNA5 0 0 288 288 1 1
DDIT4 GOLPH3 0 0 294 294 1 1
DDIT4 NGDN 0 0 211 211 1 1
DDIT4 NUPR1 0 0 235 235 1 2
DDIT4 TMEM45A 0 0 218 337 1 1
DDIT4 EIF5B 0 0 286 286 1 1
DDIT4 SLC2A3 0 0 193 193 1 1
DDIT4 ARCN1 0 0 0 191 1 1
DDIT4 MKNK2 0 0 150 185 1 1
DDIT4 TNFRSF12A 0 0 117 155 1 1
DDIT4 PPIF 0 0 101 162 1 1
DDIT4 MAP2K1 0 0 173 173 1 1
DDIT4 PHLDA3 0 0 293 308 1 1
DDIT4 OASL 0 0 123 162 1 1
DDIT4 CHAC1 0 0 386 399 1 1
DDIT4 STK11 0 0 469 469 1 2
DDIT4 BRCA1 0 0 166 165 1 2
DDIT4 AKT2 0 0 247 257 1 2
DDIT4 RB1CC1 0 0 294 294 1 2
DDIT4 LARP1 0 0 137 193 1 1
DDIT4 NFE2L2 0 0 193 193 1 2
DDIT4 CREB1 0 0 201 280 1 2
DDIT4 G0S2 0 0 134 173 1 1
DDIT4 MOV10 0 0 120 159 1 1
DDIT4 CREBBP 0 0 95 190 1 1
DDIT4 ACO2 0 0 61 154 1 1
DDIT4 GRB10 0 0 232 245 1 1
DDIT4 ESRRA 0 0 328 341 1 1
DDIT4 PFKFB3 0 0 320 342 1 2
DDIT4 EPO 0 0 246 245 1 2
DDIT4 ATF5 0 0 150 199 1 1
DDIT4 PLK1 0 0 166 165 1 2
DDIT4 PPP2R2A 0 0 203 203 1 1
DDIT4 SIRT2 0 0 143 173 1 2
DDIT4 ROGDI 0 0 94 150 1 1
DDIT4 SLC38A9 0 0 283 282 1 1
DDIT4 FBXO32 0 0 519 549 1 2
DDIT4 CCNB1 0 0 167 167 1 1
DDIT4 FAM129A 0 0 146 219 1 1
DDIT4 ANXA5 0 0 181 181 1 2
DDIT4 BCL2L1 0 0 246 252 1 2
DDIT4 RELA 0 0 143 219 1 2
DDIT4 ALDOA 0 0 103 293 1 1
DDIT4 ZNF732 0 0 155 154 1 1
DDIT4 KLF6 0 0 320 320 1 1
DDIT4 SLC25A20 0 0 95 151 1 1
DDIT4 P4HA2 0 0 167 199 1 1
DDIT4 JADE2 0 0 66 232 1 1
DDIT4 PIK3R4 0 0 171 171 1 2
DDIT4 MAP2K7 0 0 292 292 1 1
DDIT4 GABARAPL2 0 0 167 167 1 2
DDIT4 PGAM4 0 0 210 217 1 1
DDIT4 FKBP8 0 0 397 412 1 1
DDIT4 PRR5 0 0 383 393 1 1
DDIT4 DUSP5 0 0 128 484 1 1
DDIT4 GAPDH 0 0 345 360 1 2
DDIT4 LARS2 0 0 172 173 1 1
DDIT4 CYP1A1 0 0 125 173 1 2
DDIT4 ATG14 0 0 245 244 1 2
DDIT4 SPSB1 0 0 166 248 1 1
DDIT4 ENO1 0 0 181 249 1 1
DDIT4 MT1M 0 0 155 154 1 1
DDIT4 KLHL24 0 0 266 484 1 1
DDIT4 TLR4 0 0 127 150 1 2
DDIT4 SMAD2 0 0 136 169 1 2
DDIT4 PHACTR3 0 0 66 331 1 1
DDIT4 ATXN1 0 0 0 193 1 1
DDIT4 SLC1A7 0 0 328 328 1 1
DDIT4 MAD2L1BP 0 0 83 179 1 1
DDIT4 PKIB 0 0 243 242 1 1
DDIT4 CXCL8 0 0 218 218 1 2
DDIT4 MAPK13 0 0 81 178 1 1
DDIT4 NDRG1 0 0 420 472 1 1
DDIT4 ID1 0 0 135 180 1 1
DDIT4 IL1B 0 0 243 242 1 2
DDIT4 HIF3A 0 0 137 176 1 1
DDIT4 SH3BP4 0 0 134 171 1 1
DDIT4 NEDD4 270 0 140 350 1 2
DDIT4 HIF1A 0 0 636 636 1 2
DDIT4 EDN1 0 0 155 154 1 1
DDIT4 AK4 0 0 139 171 1 1
DDIT4 BAG3 0 0 155 175 1 2
DDIT4 CACNA1C 0 0 59 203 1 1
DDIT4 HOXA4 0 0 61 614 1 1
DDIT4 LIAS 0 0 0 189 1 1
DDIT4 PSAT1 0 0 150 171 1 1
DDIT4 MTSS1 0 0 70 347 1 1
DDIT4 EGR1 0 0 236 267 1 2
DDIT4 CDK2 0 0 171 171 1 2
DDIT4 MAP1LC3A 0 0 141 246 1 2
DDIT4 HRAS 0 0 204 258 1 2
DDIT4 CTNNB1 0 0 260 260 1 2
DDIT4 HSD11B1L 0 0 123 177 1 1
DDIT4 E2F2 0 0 161 199 1 1
DDIT4 HILPDA 0 0 181 241 1 1
DDIT4 NAT10 0 0 108 163 1 1
DDIT4 MAPKAP1 0 0 166 256 1 1
DDIT4 MTOR 0 0 703 703 1 2
DDIT4 TAOK3 0 0 0 189 1 1
DDIT4 SCO2 0 0 212 212 1 1
DDIT4 NOTCH1 0 0 210 229 1 2
DDIT4 CXCR4 0 0 203 203 1 2
DDIT4 CYR61 0 0 150 379 1 1
DDIT4 PLEK 0 0 188 188 1 1
DDIT4 RPL32 0 0 94 460 1 1
DDIT4 MYOG 0 0 211 222 1 1
DDIT4 RPS6 0 0 507 518 1 2
DDIT4 BCL2L2-PABPN1 0 0 161 167 1 1
DDIT4 IL6 0 0 281 281 1 2
DDIT4 PIK3C3 0 0 325 325 1 2
DDIT4 MXI1 0 0 208 226 1 1
DDIT4 SYTL1 0 0 60 154 1 1
DDIT4 GABARAPL1 0 0 235 235 1 2
DDIT4 USP6 0 0 157 156 1 1
DDIT4 SPOCD1 0 0 108 163 1 1
DDIT4 FABP5 0 0 163 178 1 1
DDIT4 CXCL12 0 0 143 166 1 2
DDIT4 SLC38A2 0 0 218 218 1 1
DDIT4 CIART 0 0 90 229 1 1
DDIT4 HNRNPH1 270 0 0 270 1 1
DDIT4 CDKN1A 0 0 322 356 1 2
DDIT4 GATSL3 0 0 268 284 1 1
DDIT4 AR 0 0 157 158 1 2
DDIT4 RHOA 0 0 87 151 1 2
DDIT4 EIF4G1 0 0 321 321 1 2
DDIT4 GDF10 0 0 0 177 1 1
DDIT4 HSPA8 0 0 128 154 1 2
DDIT4 CUL4A 270 0 447 579 1 1
DDIT4 SIRT3 0 0 157 156 1 2
DDIT4 ARL2BP 0 0 46 206 1 1
DDIT4 KLF15 0 0 469 506 1 1
DDIT4 MAPK3 0 0 278 283 1 2
DDIT4 MMP9 0 0 194 243 1 2
DDIT4 KEAP1 103 0 161 215 1 2
DDIT4 BNIP3 0 0 600 622 1 2
DDIT4 SQSTM1 0 0 325 325 1 2
DDIT4 PCK2 0 0 141 222 1 1
DDIT4 JUNB 0 0 60 157 1 1
DDIT4 FOXG1 0 0 0 252 1 1
DDIT4 ACTB 0 0 324 330 1 2
DDIT4 INS 0 0 450 450 1 2
DDIT4 ATG13 0 0 362 366 1 2
DDIT4 CEBPA 0 0 120 156 1 1
DDIT4 SOX2 0 0 150 173 1 2
DDIT4 COX4I1 0 0 140 163 1 1
DDIT4 HSP90AA1 0 0 211 211 1 2
DDIT4 ITGB3BP 0 0 53 259 1 1
DDIT4 FOSL1 0 0 103 213 1 1
DDIT4 TFEB 0 0 219 236 1 2
DDIT4 FBXW7 0 0 293 293 1 2
DDIT4 DAPK1 0 0 150 185 1 2
DDIT4 TNIP3 0 0 112 173 1 1
DDIT4 JUN 0 0 294 309 1 2
DDIT4 PLCG1 270 0 0 285 1 1
DDIT4 SLC16A4 0 0 181 181 1 1
DDIT4 POLDIP3 0 0 219 219 1 1
DDIT4 MAPK12 0 0 70 168 1 1
DDIT4 SERPINB2 0 0 150 214 1 1
DDIT4 BCL2L11 0 0 260 260 1 2
DDIT4 TSC1 0 900 761 975 1 2
DDIT4 ULK2 0 0 242 241 1 2
DDIT4 PIK3CG 0 0 180 179 1 1
DDIT4 ZBTB16 0 0 309 313 1 1
DDIT4 TNFSF10 0 0 171 185 1 2
DDIT4 CAV1 0 0 142 165 1 2
DDIT4 HSPA1A 0 0 162 161 1 1
DDIT4 AKT1S1 0 0 520 552 1 1
DDIT4 CCNA2 0 0 125 186 1 1
DDIT4 CHEK1 0 0 173 173 1 2
DDIT4 SNCA 0 0 203 204 1 2
DDIT4 SLC16A3 0 0 261 285 1 1
DDIT4 MMP2 0 0 162 161 1 2
DDIT4 ENSG00000270024 0 0 141 206 1 1
DDIT4 SKA2 0 0 142 231 1 1
DDIT4 NFATC3 0 0 157 175 1 1
DDIT4 IRS2 0 0 206 206 1 1
DDIT4 DEPDC5 0 0 160 162 1 1
DDIT4 EIF3K 0 0 51 155 1 1
DDIT4 CD8A 0 0 154 153 1 1
DDIT4 FAM84B 0 0 69 172 1 1
DDIT4 IGFBP3 0 0 291 328 1 2
DDIT4 NPRL3 0 0 135 154 1 1
DDIT4 NCK2 0 0 47 260 1 1
DDIT4 PNMT 0 0 0 254 1 1
DDIT4 C8orf44 0 0 212 212 1 1
DDIT4 ARNT 0 0 369 369 1 2
DDIT4 DNAJC3 0 0 103 192 1 1
DDIT4 KRT15 0 0 53 198 1 1
DDIT4 SP6 0 0 57 157 1 1
DDIT4 YWHAE 0 900 0 901 1 1
DDIT4 SLC25A24 0 0 123 357 1 1
DDIT4 CPZ 0 0 67 165 1 1
DDIT4 PSMD1 0 0 123 160 1 1
DDIT4 CISH 0 0 108 174 1 1
DDIT4 NR3C1 0 0 404 404 1 1
DDIT4 FKBP1A 0 0 376 379 1 2
DDIT4 DAPK3 0 0 0 154 1 2
DDIT4 CTGF 0 0 184 219 1 1
DDIT4 RPS6KB2 0 0 218 281 1 2
DDIT4 SESN2 0 0 567 593 1 2
DDIT4 LRRC42 0 0 134 170 1 1
DDIT4 PXN 0 0 295 322 1 1
DDIT4 TNS1 0 0 180 199 1 1
DDIT4 PHLDA1 0 0 144 234 1 1
DDIT4 ENO2 0 0 113 165 1 1
DDIT4 SPCS2 0 0 74 171 1 1
DDIT4 MAPK8 0 0 154 153 1 2
DDIT4 SKP2 0 0 210 210 1 2
DDIT4 PRKAB1 0 0 261 261 1 2
DDIT4 RASSF2 0 0 0 208 1 1
DDIT4 BHLHE40 0 0 282 334 1 1
DDIT4 FASN 0 0 261 285 1 2
DDIT4 IGFBP1 0 0 145 184 1 1
DDIT4 PLAU 0 0 181 181 1 1
DDIT4 RNF19A 0 0 0 190 1 1
DDIT4 OCEL1 0 0 134 157 1 1
DDIT4 EGF 0 0 211 211 1 2
DDIT4 GADD45B 0 0 260 276 1 1
DDIT4 RPS6KA3 0 0 232 231 1 1
DDIT4 PLK2 0 0 195 195 1 1
DDIT4 CYCS 0 0 246 245 1 2
DDIT4 DUSP12 0 0 320 366 1 1
DDIT4 CASP9 0 0 206 206 1 2
DDIT4 KLF13 0 0 54 218 1 1
DDIT4 FLCN 0 0 181 181 1 1
DDIT4 NMRK2 0 0 150 281 1 1
DDIT4 SESN3 0 0 112 168 1 1
DDIT4 PPARA 0 0 170 249 1 2
DDIT4 WASH2P 0 0 154 153 1 1
DDIT4 HIF1AN 0 0 180 219 1 1
DDIT4 IER3 0 0 129 154 1 1
DDIT4 TAT 0 0 102 152 1 2
DDIT4 HSP90B1 0 0 146 199 1 1
DDIT4 CEBPD 0 0 249 282 1 1
DDIT4 PDCD4 0 0 232 231 1 2
DDIT4 RPTOR 0 0 602 607 1 2
DDIT4 CSDE1 0 0 260 260 1 1
DDIT4 CDKN1C 0 0 294 306 1 1
DDIT4 PIK3R1 0 0 194 219 1 1
DDIT4 DICER1 0 0 171 171 1 1
DDIT4 HSPA4 129 0 140 218 1 1
DDIT4 CYP1B1 0 0 142 232 1 1
DDIT4 HERPUD1 0 0 101 182 1 1
DDIT4 CUL1 0 0 170 169 1 1
DDIT4 PGK1 0 0 325 325 1 2
DDIT4 MTSS1L 0 0 0 179 1 1
DDIT4 SGK2 0 0 103 221 1 1
DDIT4 CASP8 0 0 181 181 1 2
DDIT4 ALB 0 0 181 181 1 2
DDIT4 CCL2 0 0 155 154 1 2
DDIT4 CNTFR 0 0 113 150 1 1
DDIT4 CD276 0 0 296 296 1 1
DDIT4 EIF4A1 0 0 225 231 1 1
DDIT4 IFI6 0 0 114 174 1 1
DDIT4 ERO1L 0 0 195 251 1 1
DDIT4 FAM169A 0 0 107 197 1 1
DDIT4 SNCAIP 0 0 123 151 1 2
DDIT4 BIRC3 0 0 166 165 1 1
DDIT4 SMAD3 0 0 150 198 1 2
DDIT4 BPGM 0 0 113 159 1 1
DDIT4 EP300 0 0 211 230 1 2
DDIT4 MFSD3 0 0 108 162 1 1
DDIT4 PIK3IP1 0 0 194 362 1 1
DDIT4 CDH1 0 0 193 193 1 2
DDIT4 NXF1 0 0 113 201 1 1
DDIT4 MIOS 0 0 154 153 1 1
DDIT4 C4orf33 0 0 141 227 1 1
DDIT4 CDK6 0 0 149 164 1 2
DDIT4 FKBP4 0 0 230 248 1 1
DDIT4 SIRT6 0 0 154 175 1 2
DDIT4 FBXL20 0 0 125 156 1 1
DDIT4 MOGAT3 0 0 115 175 1 1
DDIT4 YWHAG 0 900 61 904 1 1
DDIT4 HYOU1 0 0 63 158 1 1
DDIT4 ART3 0 0 62 206 1 1
DDIT4 RHOB 0 0 108 340 1 1
DDIT4 SLC3A2 103 0 193 245 1 1
DDIT4 TCEB3 0 0 71 345 1 1
DDIT4 NR3C2 0 0 108 153 1 1
DDIT4 FKBP5 0 0 423 446 1 1
DDIT4 TSC22D1 0 0 142 225 1 1
DDIT4 REM1 0 0 53 196 1 1
DDIT4 YWHAQ 0 900 49 900 1 1
DDIT4 RPS6KB1 0 0 632 668 1 2
DDIT4 GAMT 0 0 147 165 1 1
DDIT4 SERPINE1 0 0 183 241 1 1
DDIT4 PPP2CA 0 0 544 554 1 1
DDIT4 PER1 0 0 174 193 1 1
DDIT4 CDK1 0 0 160 159 1 2
DDIT4 EIF4E 0 0 504 515 1 2
DDIT4 CYP24A1 0 0 124 223 1 1
DDIT4 ADRA1D 0 0 72 215 1 1
DDIT4 SESN1 0 0 517 536 1 1
DDIT4 IPMK 0 0 124 155 1 1
DDIT4 LOX 0 0 180 179 1 2
DDIT4 SGK1 0 0 404 458 1 2
DDIT4 IRS1 0 0 392 400 1 2
DDIT4 KCNA1 0 0 328 328 1 1
DDIT4 BCL2L2 0 0 161 174 1 1
DDIT4 CCND1 0 0 310 325 1 2
DDIT4 PPP1R3B 0 0 161 192 1 1
DDIT4 SREBF2 0 0 140 171 1 1
DDIT4 ALDOC 0 0 166 316 1 1
DDIT4 DDB2 0 0 216 216 1 1
DDIT4 PRKAA1 0 0 142 202 1 2
DDIT4 ENSG00000260170 0 0 0 188 1 1
DDIT4 RRM2B 0 0 163 163 1 1
DDIT4 ANKRD37 0 0 247 246 1 1
DDIT4 FLT3LG 0 0 323 323 1 1
DDIT4 OSGIN2 0 0 96 158 1 1
DDIT4 LIN28A 0 0 123 158 1 1
DDIT4 SZT2 0 0 155 195 1 1
DDIT4 KLF9 0 0 241 240 1 1
DDIT4 RHEB 0 0 662 669 1 2
DDIT4 BCAT2 0 0 368 389 1 1
DDIT4 BAK1 0 0 122 158 1 2
DDIT4 TXN 0 0 170 169 1 1
DDIT4 ERH 0 0 62 318 1 1
DDIT4 MAP4K3 0 0 213 213 1 1
DDIT4 CAT 0 0 167 167 1 2
DDIT4 PDPK1 115 0 235 362 1 2
DDIT4 CELF1 0 0 125 179 1 1
DDIT4 TNF 0 0 263 264 1 2
DDIT4 ANKRD9 0 0 181 198 1 1
DDIT4 HSPA13 0 0 167 167 1 1
DDIT4 MAGED2 0 0 120 157 1 1
DDIT4 LARS 0 0 205 209 1 1
DDIT4 BDNF 0 0 203 203 1 2
DDIT4 ANKRD1 0 0 194 200 1 1
DDIT4 SLC1A5 0 0 113 173 1 1
DDIT4 CD44 0 0 150 182 1 2
DDIT4 VDR 0 0 279 279 1 2
DDIT4 PIK3R2 0 0 165 197 1 1
DDIT4 CASP2 0 0 162 172 1 1
DDIT4 UCP3 0 0 142 274 1 1
DDIT4 VPS51 0 0 0 190 1 1
DDIT4 AEN 0 0 161 175 1 1
DDIT4 KDM3A 0 0 183 234 1 1
DDIT4 RCAN1 0 0 181 198 1 2
DDIT4 GPATCH11 0 0 171 228 1 1
DDIT4 COL8A2 0 0 61 223 1 1
DDIT4 GLS2 0 0 204 204 1 1
DDIT4 ZDHHC9 0 0 54 231 1 1
DDIT4 NFAT5 0 0 112 173 1 1
DDIT4 MT2A 0 0 242 241 1 1
DDIT4 SLC7A11 0 0 293 293 1 2
DDIT4 EEF2 0 0 365 416 1 2
DDIT4 ELOA3B 0 0 0 323 1 1
DDIT4 PPP1R15A 0 0 348 381 1 2
DDIT4 CCND2 0 0 159 160 1 1
DDIT4 TEX19 0 0 125 156 1 1
DDIT4 RPS6KA2 0 0 243 260 1 1
DDIT4 TNFAIP3 0 0 124 179 1 2
DDIT4 LAMTOR3 0 0 166 179 1 1
DDIT4 ATG4B 0 0 260 260 1 2
DDIT4 APOC3 0 0 0 213 1 1
DDIT4 C10orf10 0 0 195 227 1 1
DDIT4 CLEC2L 0 0 0 206 1 1
DDIT4 DHRS1 0 0 90 242 1 1
DDIT4 DRAM1 0 0 261 277 1 2
DDIT4 FGF2 0 0 158 157 1 2
DDIT4 BMF 0 0 294 604 1 1
DDIT4 TXNIP 270 0 986 990 1 2
DDIT4 BCL2A1 0 0 137 174 1 1
DDIT4 GADD45A 0 0 402 468 1 1
DDIT4 PKM 0 0 243 261 1 1
DDIT4 C19orf66 0 0 96 191 1 1
DDIT4 PFKFB4 0 0 296 317 1 1
DDIT4 CCPG1 0 0 127 174 1 1
DDIT4 ATF3 0 0 369 387 1 2
DDIT4 PGAM1 0 0 209 216 1 1
DDIT4 UVRAG 0 0 181 181 1 2
DDIT4 PARP3 0 0 194 194 1 1
DDIT4 CSF1R 0 0 108 169 1 1
DDIT4 IGF1 0 0 413 416 1 2
DDIT4 CCND3 0 0 194 194 1 1
DDIT4 CDC16 0 0 157 164 1 1
DDIT4 CCNG2 0 0 293 293 1 1
DDIT4 PINK1 0 0 205 205 1 2
DDIT4 FOXO4 0 0 183 201 1 1
DDIT4 P4HA1 0 0 322 403 1 1
DDIT4 EIF4EBP1 0 0 654 663 1 2
DDIT4 SQRDL 0 0 89 228 1 1
DDIT4 CCNE2 0 0 233 312 1 1
DDIT4 AKAP4 0 0 0 187 1 1
DDIT4 STC2 0 0 340 430 1 1
DDIT4 FBXO2 0 0 81 175 1 1
DDIT4 ERBB2 0 0 247 263 1 2
DDIT4 SLC25A23 0 0 0 183 1 1
DDIT4 BBC3 0 0 217 239 1 2
DDIT4 PLEKHF1 0 0 113 248 1 1
DDIT4 PPARG 0 0 246 245 1 2
DDIT4 AKT1 0 0 601 609 1 2
DDIT4 ZMAT3 0 0 154 160 1 1
DDIT4 SGK3 0 0 178 240 1 1
DDIT4 ATF4 0 0 350 364 1 2
DDIT4 CD4 0 0 138 157 1 2
DDIT4 CA9 0 0 325 350 1 1
DDIT4 SLC36A1 0 0 398 398 1 1
DDIT4 KLF4 0 0 158 157 1 2
DDIT4 IKBKB 0 0 167 167 1 2
DDIT4 ATF6 0 0 283 291 1 2
DDIT4 SCN5A 0 0 0 189 1 1
DDIT4 DROSHA 0 0 139 178 1 1
DDIT4 PRR15L 0 0 108 173 1 1
DDIT4 DLG1 0 0 102 158 1 1
DDIT4 EDF1 0 0 54 215 1 1
DDIT4 PPP2R4 0 0 235 235 1 1
DDIT4 ASNS 0 0 321 396 1 1
DDIT4 HMOX1 0 0 152 162 1 2
DDIT4 FASTKD3 0 0 94 162 1 1
DDIT4 HSD17B12 0 0 76 157 1 1
DDIT4 TCHP 0 0 213 213 1 1
DDIT4 RAC2 0 0 150 173 1 1
DDIT4 YY1 0 0 170 169 1 1
DDIT4 RRAGA 0 0 397 396 1 1
DDIT4 NDUFA4L2 0 0 159 183 1 1
DDIT4 SKP1 0 0 180 179 1 2
DDIT4 EIF2S1 0 0 325 325 1 2
DDIT4 BNIP3L 0 0 395 394 1 2
DDIT4 GADD45G 0 0 261 280 1 1
DDIT4 TSC2 0 900 876 987 1 2
DDIT4 DDB1 270 0 279 463 1 1
DDIT4 RBX1 0 0 202 202 1 1
DDIT4 YPEL2 0 0 113 168 1 1
DDIT4 CDKN1B 0 0 284 284 1 2
DDIT4 BGLAP 0 0 90 185 1 1
DDIT4 WDR24 0 0 161 181 1 1
DDIT4 FBXW5 0 0 184 200 1 1
DDIT4 FOXO3 0 0 406 419 1 2
DDIT4 SLC2A4 0 0 217 217 1 1
DDIT4 EGR4 0 0 92 156 1 1
DDIT4 ETFDH 0 0 0 214 1 1
DDIT4 YWHAB 270 900 657 972 1 1
DDIT4 SRC 0 0 166 184 1 2
DDIT4 ATG3 0 0 193 193 1 2
DDIT4 OCIAD1 0 0 0 189 1 1
DDIT4 CDKN3 0 0 162 182 1 1
DDIT4 FLT1 0 0 194 194 1 1
DDIT4 VHL 44 0 325 331 1 2
DDIT4 TXNDC9 0 0 251 250 1 1
DDIT4 FAM162A 0 0 180 202 1 1
DDIT4 EIF2AK3 0 0 286 298 1 2
DDIT4 TP53INP1 0 0 460 471 1 2
DDIT4 ACLY 0 0 181 181 1 1
DDIT4 S100A6 0 0 96 152 1 1
DDIT4 CSF1 0 0 122 166 1 1
DDIT4 YWHAH 0 900 74 903 1 1
DDIT4 NDRG2 0 0 100 156 1 1
DDIT4 ATG16L1 0 0 193 193 1 2
DDIT4 TBC1D7 0 800 391 873 1 2
DDIT4 CEBPB 0 0 310 391 1 2
DDIT4 RAB2B 0 0 57 203 1 1
DDIT4 ZADH2 0 0 178 240 1 1
DDIT4 KLF2 0 0 157 162 1 1
DDIT4 TRIM44 0 0 90 182 1 1
DDIT4 CCNG1 0 0 193 248 1 1
DDIT4 ZFAND2A 0 0 96 184 1 1
DDIT4 SALL4 0 0 97 159 1 1
DDIT4 GSK3B 270 0 228 449 1 2
DDIT4 CDKN2A 0 0 187 187 1 2
DDIT4 SOCS2 0 0 136 156 1 1
DDIT4 RPS27A 270 0 44 272 1 1
DDIT4 FAM98A 0 0 0 199 1 1
DDIT4 SFN 0 900 167 914 1 2
DDIT4 ADM 0 0 169 204 1 2
DDIT4 TCEB3CL 0 0 0 323 1 1
DDIT4 GPR65 0 0 86 181 1 1
DDIT4 ATG12 0 0 284 284 1 2
DDIT4 TNFRSF10B 0 0 184 204 1 2
DDIT4 VPS13A 0 0 46 192 1 1
DDIT4 RFX7 0 0 66 161 1 1
DDIT4 SLC25A16 0 0 49 262 1 1
DDIT4 PTGS2 0 0 150 173 1 2
DDIT4 CASP3 0 0 334 334 1 2
DDIT4 EIF4B 0 0 388 415 1 1
DDIT4 ATG101 0 0 155 154 1 2
DDIT4 EGLN1 0 0 340 386 1 1
DDIT4 FCHSD1 0 0 171 171 1 1
DDIT4 TRIB3 0 0 380 411 1 2
DDIT4 LPIN1 0 0 325 326 1 2
DDIT4 DNAJB9 0 0 208 229 1 2
DDIT4 FKBP9 0 0 61 310 1 1
DDIT4 RHOBTB3 0 0 47 193 1 1
DDIT4 BGN 0 0 0 188 1 1
DDIT4 CDC25A 0 0 181 181 1 1
DDIT4 FNDC7 0 0 160 241 1 1
DDIT4 PFKFB1 0 0 129 219 1 1
DDIT4 RRAGD 0 0 397 396 1 1
DDIT4 IVNS1ABP 0 0 140 232 1 1
DDIT4 WARS 0 0 120 211 1 1
DDIT4 TCEB3B 0 0 0 323 1 1
DDIT4 LRRK2 0 0 127 162 1 2
DDIT4 PIK3CB 0 0 180 179 1 1
DDIT4 PMAIP1 0 0 265 281 1 2
DDIT4 TAOK1 0 0 67 210 1 1
DDIT4 C9orf152 0 0 143 206 1 1
DDIT4 ZNF383 0 0 140 200 1 1
DDIT4 RPL3L 0 0 103 223 1 1
DDIT4 DUSP1 0 0 322 685 1 1
DDIT4 EIF4EBP2 0 0 389 402 1 1
DDIT4 SUFU 0 0 67 321 1 1
DDIT4 EEF2K 0 0 374 374 1 2
DDIT4 BRAT1 0 0 143 177 1 1
DDIT4 BECN1 0 0 390 390 1 2
DDIT4 SOD2 0 0 183 183 1 2
DDIT4 KRAS 0 0 168 249 1 2
DDIT4 FOXO1 0 0 418 443 1 2
DDIT4 SLC25A46 0 0 54 266 1 1
DDIT4 EPAS1 0 0 235 313 1 2
DDIT4 MLST8 0 0 469 481 1 1
DDIT4 EIF4A2 0 0 243 242 1 1
DDIT4 BTRC 270 0 212 400 1 1
DDIT4 MYH13 0 0 0 252 1 1
DDIT4 HSPA5 0 0 249 248 1 2
DDIT4 ROMO1 0 0 82 158 1 1
DDIT4 RRAGC 0 0 451 451 1 1
DDIT4 MSTN 0 0 391 415 1 1
DDIT4 DEPTOR 0 0 594 599 1 2
DDIT4 ANGPTL4 0 0 181 181 1 1
DDIT4 WDR59 0 0 194 194 1 1
DDIT4 SOCS3 0 0 154 172 1 1
DDIT4 YWHAZ 486 900 90 950 1 1
DDIT4 FOS 0 0 233 308 1 2
DDIT4 BIN3 0 0 60 159 1 1
DDIT4 HSPB2 192 0 90 277 1 1
DDIT4 ADAM17 0 0 134 221 1 1
DDIT4 LSS 0 0 104 165 1 1
DDIT4 ZNF846 0 0 151 150 1 1
DDIT4 MAP1LC3B 0 0 322 334 1 2
DDIT4 ATP6AP1 0 0 0 191 1 1
DDIT4 ULK1 0 0 370 383 1 2
DDIT4 RPS6KA1 0 0 391 390 1 1
DDIT4 PRKCA 0 0 244 243 1 1
DDIT4 CA12 0 0 160 184 1 1
DDIT4 AKT3 0 0 232 231 1 2
DDIT4 FN1 0 0 139 172 1 2
DDIT4 FNIP1 0 0 164 163 1 1
DDIT4 TBP 0 0 157 164 1 1
DDIT4 DDIT4L 0 0 842 180 1 1
DDIT4 SIRT1 0 0 240 239 1 2
DDIT4 EOMES 0 0 329 329 1 1
DDIT4 MCL1 0 0 260 266 1 2
DDIT4 ERVW-1 0 0 242 241 1 1
DDIT4 RGS2 0 0 155 340 1 1
DDIT4 SPI1 0 0 72 169 1 1
DDIT4 TCEB3C 0 0 0 323 1 1
DDIT4 COPS5 0 0 74 217 1 1
DDIT4 RBM38 0 0 182 217 1 1
DDIT4 ESR1 0 0 245 244 1 2
DDIT4 PIM2 0 0 150 173 1 1
DDIT4 MAP3K5 0 0 170 169 1 1
DDIT4 SMAD7 0 0 95 151 1 1
DDIT4 PDK4 0 0 219 219 1 1
DDIT4 BCL2L14 0 0 113 183 1 1
DDIT4 ZNF419 0 0 94 156 1 1
DDIT4 ATG5 0 0 340 340 1 2
DDIT4 C2CD4B 0 0 57 176 1 1
DDIT4 YIPF1 0 0 303 318 1 1
DDIT4 ZFAND2B 0 0 0 200 1 1
DDIT4 PRAMEF12 0 0 108 172 1 1
DDIT4 MT1G 0 0 161 161 1 1
DDIT4 SLC35C1 0 0 90 172 1 1
DDIT4 HIPK2 0 0 134 194 1 2
DDIT4 TP63 0 900 308 927 1 2
DDIT4 HEMGN 0 0 83 206 1 1
DDIT4 OCIAD2 0 0 0 189 1 1
DDIT4 XBP1 0 0 321 321 1 2
DDIT4 PTEN 0 0 469 493 1 2
DDIT4 VEGFA 0 0 392 414 1 2
DDIT4 IRF4 0 0 55 189 1 1
DDIT4 PRKAA2 0 0 387 386 1 2
DDIT4 SLFN14 0 0 82 176 1 1
DDIT4 MYOD1 0 0 217 223 1 1
DDIT4 RRAGB 0 0 397 396 1 1
DDIT4 C12orf5 0 0 249 256 1 1
DDIT4 AIMP2 0 0 75 235 1 1
DDIT4 NFKBIA 0 0 231 303 1 2
DDIT4 ZNF37A 0 0 112 209 1 1
DDIT4 LDHA 0 0 369 370 1 2
DDIT4 AMBRA1 0 0 150 184 1 2
DDIT4 SLC36A4 0 0 398 398 1 1
DDIT4 TCF24 0 0 162 250 1 1
DDIT4 SREBF1 0 0 283 306 1 1
DDIT4 EIF4EBP3 0 0 398 398 1 1
DDIT4 MAPK14 0 0 133 175 1 2
DDIT4 TIMP3 0 0 282 296 1 1
DDIT4 ATM 0 0 324 323 1 2
DDIT4 IGF2 0 0 144 164 1 1
DDIT4 NDUFS2 0 0 71 175 1 1
DDIT4 EIF3F 0 0 209 251 1 1
DDIT4 TRIM63 0 0 468 478 1 1
DDIT4 POLI 0 0 91 189 1 1
DDIT4 TTI1 0 0 202 219 1 1
DDIT4 FOSL2 0 0 143 165 1 1
DDIT4 GDF15 0 0 263 313 1 1
DDIT4 BTG2 0 0 245 339 1 1
DDIT4 GIMAP7 0 0 90 152 1 1
DDIT4 EGLN2 0 0 210 237 1 1
DDIT4 ATG7 0 0 310 309 1 2
DDIT4 FOSB 0 0 157 372 1 1
DDIT4 PPARGC1B 0 0 113 194 1 1
DDIT4 NAMPT 0 0 101 157 1 2
DDIT4 SMIM14 0 0 112 175 1 1
DDIT4 GFRA1 0 0 122 160 1 1
DDIT4 IL10 0 0 151 150 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0071889 Molecular Function 14-3-3 protein binding enables IBA
GO:0005515 Molecular Function protein binding enables IPI
GO:0006915 Biological Process apoptotic process involved_in IBA
GO:0007420 Biological Process brain development involved_in ISS
GO:0071549 Biological Process cellular response to dexamethasone stimulus involved_in IEA
GO:0051607 Biological Process defense response to virus involved_in IDA
GO:0035556 Biological Process intracellular signal transduction involved_in ISS
GO:0042771 Biological Process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator involved_in ISS
GO:0032007 Biological Process negative regulation of TOR signaling involved_in IBA
GO:0032007 Biological Process negative regulation of TOR signaling involved_in IMP
GO:0045820 Biological Process negative regulation of glycolytic process involved_in IEA
GO:0030182 Biological Process neuron differentiation involved_in ISS
GO:0001764 Biological Process neuron migration involved_in ISS
GO:0048011 Biological Process neurotrophin TRK receptor signaling pathway involved_in ISS
GO:0032984 Biological Process protein-containing complex disassembly involved_in IEA
GO:0072593 Biological Process reactive oxygen species metabolic process involved_in IEA
GO:0001666 Biological Process response to hypoxia involved_in IBA
GO:0001666 Biological Process response to hypoxia involved_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005739 Cellular Component mitochondrion located_in IEA
Pathways
Name DB ID
Generic Transcription Pathway Reactome R-HSA-212436
Transcriptional Regulation by TP53 Reactome R-HSA-3700989
TP53 Regulates Metabolic Genes Reactome R-HSA-5628897
RNA Polymerase II Transcription Reactome R-HSA-73857
Gene expression (Transcription) Reactome R-HSA-74160
Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
Focal adhesion: PI3K-Akt-mTOR-signaling pathway (WP3932) WikiPathways WP3932_r124527
Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
PI3K-Akt signaling pathway (WP4172) WikiPathways WP4172_r122580
Target of rapamycin signaling (WP1471) WikiPathways WP1471_r123616
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_019058 4 mRNA None NC_000010 Reference