WIPI1

WD repeat domain, phosphoinositide interacting 1
General Information
Name WD repeat domain, phosphoinositide interacting 1
Alias
  • WD repeat domain phosphoinositide-interacting protein 1
  • WIPI-1 alpha
  • atg18 protein homolog
Synonyms FLJ10055 WIPI49 ATG18 ATG18A
Gene_family WIPI family|Autophagy related|WD repeat domain containing
organism Homo sapiens
entrez_id 55062
location 17q24.2
transcript_count 5
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
      Stringdb WD repeat domain phosphoinositide-interacting protein 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that [...]
      nextProt Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:15602573, PubMed:20114074, PubMed:20484055, PubMed:20639694, PubMed:23088497, PubMed:28561066, PubMed:31271352). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066, PubMed:31271352, PubMed:33499712). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Involved in xenophagy of Staphylococcus aureus (PubMed:22829830). Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation (PubMed:22829830). Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy (PubMed:21317285). May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway (PubMed:15020712).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    WIPI1 BioGRID Rab18 GeneID BioGRID Proximity Label-MS
    WIPI1 BioGRID VPS35 GeneID BioGRID Co-localization
    WIPI1 BioGRID AMBRA1 GeneID BioGRID Affinity Capture-Western
    WIPI1 BioGRID MRPL35 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID MRPL37 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID HGH1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID MRPS7 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID UHRF1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID MRPL13 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID HDHD5 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ATG14 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID MRPL3 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ACAA2 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID RACK1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID OPTN GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID SCO2 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID GOSR1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID COG1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ZNF185 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID UQCRFS1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID UQCRC1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID UBB GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID SSBP1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID SCO1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID NDUFA10 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID IDH2 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID AMFR GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID AK4 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ZNF787 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID OSBPL5 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID MIGA2 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ABHD11 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID PHAF1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID EDC3 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID CEP76 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID MRPL41 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ATG101 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID DNASE2B GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ATG2B GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID BCAS3 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID RPS20 GeneID BioGRID Proximity Label-MS
    WIPI1 BioGRID ATG9A GeneID BioGRID Affinity Capture-Western
    WIPI1 BioGRID FLT3 GeneID BioGRID Positive Genetic
    WIPI1 BioGRID S100A7 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID ESR1 GeneID BioGRID Reconstituted Complex
    WIPI1 BioGRID AR GeneID BioGRID Reconstituted Complex
    WIPI1 BioGRID ATG2A GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID HNRNPA3P1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID PKP1 GeneID BioGRID Affinity Capture-MS
    WIPI1 BioGRID LGALS7 GeneID BioGRID Affinity Capture-MS
    WIPI1 Protein KCTD15 GeneID HPRD None
    WIPI1 Protein ESR2 GeneID HPRD None
    WIPI1 Protein AR GeneID HPRD None
    WIPI1 Protein PPA1 GeneID HPRD None
    WIPI1 Protein ESR1 GeneID HPRD None
    WIPI1 BioGRID KCTD15 GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    WIPI1 ATP6V1B1 0 0 93 228 1 1
    WIPI1 MAP1LC3A 0 0 519 863 1 2
    WIPI1 PEX13 0 0 0 228 1 1
    WIPI1 MFN2 0 0 234 302 1 2
    WIPI1 EXOC8 0 0 207 212 1 1
    WIPI1 TGFBRAP1 0 0 150 362 1 1
    WIPI1 ACSL3 0 0 0 153 1 1
    WIPI1 SNX18 0 0 207 207 1 2
    WIPI1 INPP5B 0 0 91 170 1 1
    WIPI1 XPO1 0 0 0 212 1 1
    WIPI1 BAG3 0 0 289 331 1 2
    WIPI1 POSTN 0 0 0 217 1 1
    WIPI1 ATP6V1H 0 0 0 155 1 1
    WIPI1 NEDD4 0 0 122 155 1 2
    WIPI1 CLINT1 0 0 209 274 1 1
    WIPI1 NAE1 0 0 0 233 1 1
    WIPI1 RAB5A 0 0 378 444 1 2
    WIPI1 MTMR6 0 0 157 287 1 1
    WIPI1 CLN3 0 0 120 175 1 2
    WIPI1 SEC24B 0 0 241 341 1 1
    WIPI1 CTSL 0 0 154 155 1 1
    WIPI1 ARF3 0 0 81 152 1 1
    WIPI1 MAP3K2 0 0 0 165 1 1
    WIPI1 CHMP2B 0 0 180 228 1 2
    WIPI1 PIK3C3 0 0 885 948 1 2
    WIPI1 PIRT 0 0 467 467 1 1
    WIPI1 DNAJB4 0 0 70 308 1 1
    WIPI1 MTMR7 0 0 150 281 1 1
    WIPI1 SLC44A3 0 0 0 175 1 1
    WIPI1 PLEK 0 0 233 232 1 1
    WIPI1 TRAPPC8 0 0 390 454 1 1
    WIPI1 SEC61A1 0 0 81 173 1 1
    WIPI1 MAN2C1 0 0 0 193 1 1
    WIPI1 MTOR 0 0 469 561 1 2
    WIPI1 SEC24D 0 0 246 344 1 1
    WIPI1 MTMR3 0 0 459 473 1 2
    WIPI1 SORT1 0 0 97 192 1 1
    WIPI1 CISD1 0 0 55 159 1 1
    WIPI1 MAP1LC3B2 0 0 368 623 1 2
    WIPI1 LMAN1 0 0 142 228 1 1
    WIPI1 SCAP 0 0 0 243 1 1
    WIPI1 SIRT2 0 0 134 254 1 2
    WIPI1 ZKSCAN3 0 0 212 232 1 2
    WIPI1 TENC1 0 0 0 215 1 1
    WIPI1 PFKFB3 0 0 0 192 1 1
    WIPI1 LRSAM1 0 0 202 219 1 2
    WIPI1 FIG4 0 0 652 839 1 1
    WIPI1 ARF1 0 0 124 192 1 1
    WIPI1 ARHGEF19 0 0 206 291 1 1
    WIPI1 WDR3 0 0 0 190 1 1
    WIPI1 NSF 0 0 195 255 1 1
    WIPI1 ATG14 0 0 799 861 1 2
    WIPI1 GAPDH 0 0 171 177 1 2
    WIPI1 FKBP8 0 0 156 300 1 1
    WIPI1 GABARAPL2 0 0 801 898 1 2
    WIPI1 PIK3R4 0 0 740 881 1 2
    WIPI1 SH2D1B 0 0 322 369 1 1
    WIPI1 TSNARE1 0 0 0 164 1 1
    WIPI1 ST8SIA1 0 0 203 203 1 1
    WIPI1 UHRF1 312 0 0 311 1 1
    WIPI1 LIPM 0 0 74 151 1 1
    WIPI1 RAB33B 0 0 242 275 1 2
    WIPI1 BCL2L1 0 0 248 248 1 2
    WIPI1 ANAPC5 0 0 0 216 1 1
    WIPI1 FYCO1 0 0 370 387 1 2
    WIPI1 RICTOR 0 0 234 234 1 2
    WIPI1 ENSG00000261832 0 0 112 167 1 1
    WIPI1 USP15 0 0 94 232 1 1
    WIPI1 NPC1 0 0 103 183 1 2
    WIPI1 VAPA 0 0 363 374 1 1
    WIPI1 CDYL 0 0 0 178 1 1
    WIPI1 PIK3CA 0 0 67 150 1 2
    WIPI1 INPP5F 0 0 0 273 1 1
    WIPI1 IRGC 0 0 108 169 1 1
    WIPI1 PDK1 0 0 0 167 1 1
    WIPI1 IRGM 0 0 391 390 1 2
    WIPI1 S100A7 186 0 0 186 1 1
    WIPI1 TM9SF1 0 0 223 329 1 2
    WIPI1 MYC 0 0 150 188 1 2
    WIPI1 PARK2 0 0 325 406 1 1
    WIPI1 USF1 0 0 0 223 1 1
    WIPI1 TPK1 0 0 167 167 1 1
    WIPI1 IGF1R 0 0 74 169 1 1
    WIPI1 GPSM3 0 0 142 195 1 1
    WIPI1 NUDCD2 0 0 0 167 1 1
    WIPI1 PI3 0 0 573 573 1 1
    WIPI1 CDC14A 0 0 0 162 1 1
    WIPI1 EHMT2 0 0 160 168 1 1
    WIPI1 RB1CC1 0 0 752 840 1 2
    WIPI1 MTMR2 0 0 229 312 1 1
    WIPI1 SEC24C 0 0 155 247 1 1
    WIPI1 STK11 0 0 212 242 1 2
    WIPI1 SYNJ1 0 0 172 337 1 1
    WIPI1 PIP4K2A 0 0 72 236 1 2
    WIPI1 MFF 0 0 141 180 1 1
    WIPI1 C9orf72 0 0 113 182 1 2
    WIPI1 TFEC 0 0 108 349 1 1
    WIPI1 UBA1 0 0 76 266 1 1
    WIPI1 TAX1BP1 0 0 282 311 1 2
    WIPI1 GOLPH3 0 0 218 218 1 1
    WIPI1 VPS39 0 0 277 524 1 1
    WIPI1 SEC16A 0 0 170 182 1 2
    WIPI1 PARK7 0 0 150 209 1 1
    WIPI1 PFKFB2 0 0 51 200 1 1
    WIPI1 DDIT3 0 0 144 164 1 2
    WIPI1 TNS3 0 0 0 215 1 1
    WIPI1 CTSA 0 0 137 204 1 1
    WIPI1 RASGRP2 0 0 0 164 1 1
    WIPI1 MAP1A 0 0 317 331 1 1
    WIPI1 LIPN 0 0 133 188 1 1
    WIPI1 GPR128 0 0 0 216 1 1
    WIPI1 RAB10 0 0 93 200 1 1
    WIPI1 BCAS3 0 0 113 365 1 2
    WIPI1 TP53 0 0 305 305 1 2
    WIPI1 MYH14 0 0 0 185 1 1
    WIPI1 TRIM16 0 0 95 151 1 2
    WIPI1 RAB2A 0 0 157 236 1 1
    WIPI1 ATP6V0C 0 0 138 339 1 2
    WIPI1 HMBS 0 0 90 179 1 1
    WIPI1 RASGRP1 0 0 0 164 1 1
    WIPI1 LAMP1 0 0 421 486 1 2
    WIPI1 CFLAR 0 0 61 158 1 1
    WIPI1 HTT 0 0 335 353 1 1
    WIPI1 ERN1 0 0 187 214 1 2
    WIPI1 OCRL 0 0 94 173 1 1
    WIPI1 MCOLN1 0 0 322 349 1 1
    WIPI1 RAB8A 0 0 137 241 1 2
    WIPI1 EIF2AK4 0 0 165 192 1 1
    WIPI1 CDK14 0 0 0 155 1 1
    WIPI1 ARSB 0 0 0 152 1 2
    WIPI1 RAB9A 0 0 0 267 1 2
    WIPI1 RASGRP3 0 0 0 164 1 1
    WIPI1 SNX12 0 0 0 268 1 1
    WIPI1 RHBDL3 0 0 0 165 1 1
    WIPI1 CD300C 0 0 503 503 1 1
    WIPI1 VAMP8 0 0 305 359 1 2
    WIPI1 STYK1 0 0 74 570 1 1
    WIPI1 HDAC6 0 0 234 234 1 2
    WIPI1 PAAF1 0 0 0 159 1 1
    WIPI1 CEP76 406 0 0 406 1 1
    WIPI1 HGS 0 0 270 318 1 2
    WIPI1 STK35 0 0 0 458 1 1
    WIPI1 LGALS8 0 0 261 261 1 1
    WIPI1 ARSG 0 0 202 311 1 1
    WIPI1 TPTE 0 0 0 215 1 1
    WIPI1 SNX11 0 0 0 268 1 1
    WIPI1 PLS3 0 0 0 216 1 1
    WIPI1 SEC63 0 0 181 199 1 1
    WIPI1 PIP5K1C 0 0 73 239 1 1
    WIPI1 ZMIZ1 0 0 0 225 1 1
    WIPI1 DRAM2 0 0 261 272 1 2
    WIPI1 CYSTM1 0 0 134 154 1 1
    WIPI1 ZMIZ2 0 0 205 588 1 1
    WIPI1 CASP8 0 0 135 225 1 2
    WIPI1 SGK2 0 0 0 161 1 1
    WIPI1 DNAJC18 0 0 0 150 1 1
    WIPI1 PGK1 0 0 169 191 1 2
    WIPI1 CASP7 0 0 88 259 1 1
    WIPI1 RALGPS1 0 0 0 164 1 1
    WIPI1 PPP6R2 0 0 0 198 1 1
    WIPI1 SNPH 0 0 124 279 1 1
    WIPI1 TBC1D2 0 0 96 165 1 1
    WIPI1 MIEF2 0 0 134 155 1 1
    WIPI1 ATG16L2 0 800 456 908 1 2
    WIPI1 LGALS4 0 0 358 372 1 1
    WIPI1 MAP1B 0 0 123 152 1 1
    WIPI1 MAP1LC3C 0 0 525 717 1 2
    WIPI1 DNM2 0 0 150 243 1 1
    WIPI1 CHMP3 0 0 150 214 1 1
    WIPI1 POLG 0 0 122 480 1 1
    WIPI1 SEC31B 0 0 0 158 1 1
    WIPI1 DUT 0 0 49 242 1 1
    WIPI1 RAB9B 0 0 0 267 1 1
    WIPI1 BCL2L13 0 0 218 218 1 1
    WIPI1 VPS35 0 0 171 338 1 1
    WIPI1 SUPT20H 0 0 141 194 1 1
    WIPI1 VPS26A 0 0 72 189 1 1
    WIPI1 WAC 0 0 124 173 1 1
    WIPI1 RAB32 0 0 123 217 1 2
    WIPI1 PEX5 0 0 172 171 1 1
    WIPI1 PRKAB1 0 0 120 156 1 2
    WIPI1 MAPK8 0 0 231 247 1 2
    WIPI1 BCKDK 0 0 0 165 1 1
    WIPI1 RAPGEF1 0 0 0 164 1 1
    WIPI1 ATP6V0A2 0 0 171 243 1 1
    WIPI1 WDR47 0 0 134 266 1 1
    WIPI1 PLD1 0 0 204 240 1 1
    WIPI1 VPS33A 0 0 122 173 1 1
    WIPI1 RAB38 0 0 81 473 1 1
    WIPI1 TNS1 0 0 0 215 1 1
    WIPI1 VPS18 0 0 322 467 1 1
    WIPI1 TRAPPC11 0 0 146 293 1 1
    WIPI1 RPS6KB2 0 0 74 190 1 2
    WIPI1 MAP1S 0 0 143 493 1 2
    WIPI1 DAPK3 0 0 107 161 1 2
    WIPI1 FKBP1A 0 0 138 163 1 2
    WIPI1 HSPA4 0 0 118 153 1 1
    WIPI1 TBC1D5 0 0 212 231 1 2
    WIPI1 RPTOR 0 0 395 617 1 2
    WIPI1 PSMD4 0 0 138 161 1 1
    WIPI1 TRAF6 0 0 150 155 1 2
    WIPI1 FLCN 0 0 90 165 1 1
    WIPI1 ATG4A 0 0 558 817 1 2
    WIPI1 CASP9 0 0 73 169 1 1
    WIPI1 FNBP1 0 0 0 153 1 1
    WIPI1 TBC1D15 0 0 219 372 1 1
    WIPI1 MTM1 0 0 274 400 1 1
    WIPI1 CYCS 0 0 134 221 1 1
    WIPI1 SH3GLB1 0 0 457 457 1 2
    WIPI1 LIPJ 0 0 96 164 1 1
    WIPI1 RAB8B 0 0 96 205 1 2
    WIPI1 SOS2 0 0 0 181 1 1
    WIPI1 GAK 0 0 0 252 1 1
    WIPI1 SNCA 0 0 261 261 1 2
    WIPI1 SNAP29 0 0 391 467 1 2
    WIPI1 MOCS3 0 0 0 233 1 1
    WIPI1 GORASP2 0 0 131 206 1 1
    WIPI1 SGSH 0 0 124 234 1 1
    WIPI1 CASP1 0 0 124 215 1 2
    WIPI1 ARSI 0 0 0 152 1 1
    WIPI1 AKT1S1 0 0 181 181 1 1
    WIPI1 HAO2 0 0 0 168 1 1
    WIPI1 ZFYVE27 0 0 64 226 1 1
    WIPI1 PLS1 0 0 0 216 1 1
    WIPI1 PIK3CG 0 0 157 232 1 1
    WIPI1 ULK2 0 0 603 806 1 2
    WIPI1 USP35 0 0 134 160 1 1
    WIPI1 TSC1 0 0 170 184 1 2
    WIPI1 SNX1 0 0 171 438 1 1
    WIPI1 UBA6 0 0 0 238 1 1
    WIPI1 DNAJC16 0 0 0 155 1 1
    WIPI1 SERPINA1 0 0 67 249 1 2
    WIPI1 KIAA0226L 0 0 112 249 1 1
    WIPI1 ITPR3 0 0 157 156 1 1
    WIPI1 YKT6 0 0 167 265 1 1
    WIPI1 DAPK1 0 0 260 305 1 2
    WIPI1 LAMP2 0 0 392 430 1 2
    WIPI1 CDC14B 0 0 0 162 1 1
    WIPI1 YWHAE 0 0 0 172 1 1
    WIPI1 PIP5K1A 0 0 0 213 1 1
    WIPI1 CCDC9 0 0 194 194 1 1
    WIPI1 VCP 0 0 112 189 1 2
    WIPI1 MIB2 0 0 0 329 1 1
    WIPI1 C19orf12 0 0 165 165 1 2
    WIPI1 SOD1 0 0 108 169 1 1
    WIPI1 AIP 0 0 0 248 1 1
    WIPI1 MCOLN3 0 0 123 160 1 1
    WIPI1 CAMK1D 0 0 0 150 1 1
    WIPI1 RSAD1 0 0 0 237 1 1
    WIPI1 MFN1 0 0 234 302 1 1
    WIPI1 SNX3 0 0 125 351 1 1
    WIPI1 FUNDC1 0 0 391 390 1 2
    WIPI1 SAE1 0 0 0 233 1 1
    WIPI1 MON1B 0 0 0 238 1 1
    WIPI1 ARSA 0 0 67 172 1 2
    WIPI1 TFAM 0 0 57 171 1 1
    WIPI1 ENSG00000270024 0 0 0 164 1 1
    WIPI1 ESYT2 0 0 155 188 1 1
    WIPI1 TCIRG1 0 0 161 211 1 1
    WIPI1 SLC44A2 0 0 0 175 1 1
    WIPI1 EI24 0 0 289 359 1 2
    WIPI1 HSPA8 0 0 301 346 1 2
    WIPI1 SNX8 0 0 0 350 1 1
    WIPI1 EIF4G1 0 0 161 195 1 2
    WIPI1 AR 270 0 326 486 1 1
    WIPI1 RAB24 0 0 348 408 1 2
    WIPI1 VPS28 0 0 118 173 1 1
    WIPI1 ZFYVE20 0 0 0 239 1 1
    WIPI1 ATG9A 270 0 602 938 1 2
    WIPI1 ENSG00000249884 0 0 108 176 1 1
    WIPI1 KIAA1109 0 0 144 501 1 1
    WIPI1 PLXNA1 0 0 54 218 1 1
    WIPI1 R3HDM1 0 0 89 151 1 1
    WIPI1 EHHADH 0 0 0 178 1 1
    WIPI1 ADAD1 0 0 0 173 1 1
    WIPI1 ESR2 213 0 0 213 1 1
    WIPI1 RAB1A 0 0 294 366 1 2
    WIPI1 SLC44A4 0 0 0 175 1 1
    WIPI1 PMCH 0 0 193 208 1 1
    WIPI1 PIP5K1B 0 0 48 218 1 1
    WIPI1 SEC31A 0 0 108 281 1 1
    WIPI1 RALB 0 0 211 241 1 1
    WIPI1 VPS16 0 0 183 206 1 1
    WIPI1 GABARAPL1 0 0 803 910 1 2
    WIPI1 PDK2 0 0 0 167 1 1
    WIPI1 HPGDS 0 0 448 448 1 1
    WIPI1 HADHA 0 0 0 178 1 1
    WIPI1 TFEB 0 0 509 602 1 2
    WIPI1 HSP90AA1 0 0 170 190 1 2
    WIPI1 PSEN1 0 0 123 203 1 2
    WIPI1 PLEKHA1 0 0 194 194 1 1
    WIPI1 ESYT1 0 0 159 192 1 1
    WIPI1 EXOC3 0 0 45 190 1 1
    WIPI1 ACSS3 0 0 81 158 1 1
    WIPI1 ATG13 0 0 739 868 1 2
    WIPI1 INS 0 0 241 240 1 1
    WIPI1 DNAJB5 0 0 0 202 1 1
    WIPI1 SNX10 0 0 0 268 1 2
    WIPI1 ACTB 0 0 150 168 1 1
    WIPI1 BNIP3 0 0 423 450 1 2
    WIPI1 SQSTM1 0 0 614 753 1 2
    WIPI1 KEAP1 0 0 140 165 1 2
    WIPI1 ULK4 0 0 182 212 1 1
    WIPI1 SIRT3 0 0 134 193 1 2
    WIPI1 PIP4K2B 0 0 0 211 1 1
    WIPI1 ZFYVE1 0 0 871 873 1 2
    WIPI1 RAB7B 0 0 520 633 1 1
    WIPI1 RASGRF2 0 0 0 164 1 1
    WIPI1 HECTD1 0 0 134 166 1 1
    WIPI1 PIK3C2A 0 0 146 234 1 2
    WIPI1 GORASP1 0 0 125 200 1 1
    WIPI1 TSC2 0 0 323 342 1 2
    WIPI1 VPS45 0 0 181 211 1 1
    WIPI1 VDAC1 0 0 171 202 1 2
    WIPI1 ECI2 0 0 66 242 1 1
    WIPI1 PTPDC1 0 0 0 162 1 1
    WIPI1 BNIP3L 0 0 454 469 1 2
    WIPI1 SBF2 0 0 194 215 1 1
    WIPI1 ABCD3 0 0 95 162 1 1
    WIPI1 VAMP7 0 0 310 450 1 1
    WIPI1 EIF2S1 0 0 155 154 1 2
    WIPI1 GPR89B 0 0 0 183 1 1
    WIPI1 CCZ1 0 0 211 260 1 1
    WIPI1 MITF 0 0 123 442 1 1
    WIPI1 RRAGA 0 0 141 160 1 2
    WIPI1 CCDC109B 0 0 0 185 1 1
    WIPI1 MARCH5 0 0 90 185 1 1
    WIPI1 DNAJC21 0 0 0 150 1 1
    WIPI1 TOMM20 0 0 206 239 1 1
    WIPI1 RAB11A 0 0 254 274 1 1
    WIPI1 STX17 0 0 508 590 1 2
    WIPI1 UBA3 0 0 0 233 1 1
    WIPI1 LYST 0 0 57 168 1 1
    WIPI1 SEC13 0 0 205 222 1 1
    WIPI1 CHMP4A 0 0 166 185 1 1
    WIPI1 TBK1 0 0 283 319 1 2
    WIPI1 ATG2B 0 800 690 986 1 2
    WIPI1 DCAF11 0 0 0 168 1 1
    WIPI1 RGS19 0 0 167 181 1 2
    WIPI1 NRBF2 0 0 310 309 1 2
    WIPI1 RTN3 0 0 166 165 1 1
    WIPI1 SH3YL1 0 0 66 297 1 1
    WIPI1 EIF2AK3 0 0 210 224 1 2
    WIPI1 PPA2 0 0 0 184 1 1
    WIPI1 XPNPEP3 0 0 0 166 1 1
    WIPI1 DMXL2 0 0 102 203 1 1
    WIPI1 CDKN3 0 0 46 166 1 1
    WIPI1 BNIP1 0 0 89 229 1 2
    WIPI1 GTPBP3 0 0 0 190 1 1
    WIPI1 DNAJB1 0 0 135 318 1 2
    WIPI1 ATG3 0 0 740 904 1 2
    WIPI1 USP8 0 0 112 173 1 1
    WIPI1 SLK 0 0 182 181 1 1
    WIPI1 ATG4C 0 0 502 745 1 2
    WIPI1 LRBA 0 0 0 215 1 1
    WIPI1 RASGEF1B 0 0 0 164 1 1
    WIPI1 PCSK9 0 0 47 163 1 1
    WIPI1 ENSG00000250232 0 0 562 366 1 1
    WIPI1 FOXO3 0 0 218 340 1 2
    WIPI1 SLC29A3 0 0 233 232 1 1
    WIPI1 EVA1A 0 0 134 152 1 2
    WIPI1 MCU 0 0 0 185 1 1
    WIPI1 DGAT2 0 0 0 161 1 1
    WIPI1 EEA1 0 0 310 325 1 1
    WIPI1 CCZ1B 0 0 210 259 1 1
    WIPI1 UBA7 0 0 0 234 1 1
    WIPI1 CDYL2 0 0 90 220 1 1
    WIPI1 VTI1A 0 0 52 168 1 1
    WIPI1 YIPF5 0 0 284 290 1 1
    WIPI1 CDK15 0 0 0 220 1 1
    WIPI1 SNX7 0 0 54 507 1 2
    WIPI1 NOP16 0 0 93 188 1 1
    WIPI1 IGF2R 0 0 486 485 1 1
    WIPI1 ENSA 0 0 0 171 1 1
    WIPI1 TGFBI 0 0 0 234 1 1
    WIPI1 TMEM163 0 0 167 167 1 1
    WIPI1 HAO1 0 0 0 168 1 1
    WIPI1 EIF4EBP1 0 0 195 214 1 1
    WIPI1 PIKFYVE 0 0 709 869 1 1
    WIPI1 PEX6 0 0 124 161 1 1
    WIPI1 PINK1 0 0 469 610 1 2
    WIPI1 VPS37A 0 0 53 205 1 1
    WIPI1 GSK3A 0 0 0 183 1 1
    WIPI1 HIBCH 0 0 0 201 1 1
    WIPI1 PDK3 0 0 0 167 1 1
    WIPI1 PARL 0 0 324 442 1 1
    WIPI1 VMP1 0 0 594 729 1 2
    WIPI1 TMEM74 0 0 325 338 1 2
    WIPI1 MRPS34 0 0 0 190 1 1
    WIPI1 MTMR10 0 0 0 153 1 1
    WIPI1 ATF6 0 0 210 289 1 2
    WIPI1 DNAJB14 0 0 0 150 1 1
    WIPI1 WSB1 0 0 0 279 1 1
    WIPI1 SGK3 0 0 0 164 1 1
    WIPI1 SYNJ2 0 0 49 216 1 1
    WIPI1 UBA5 0 0 46 237 1 1
    WIPI1 DUSP23 0 0 0 162 1 1
    WIPI1 MTMR14 0 0 459 545 1 1
    WIPI1 ECHS1 0 0 0 260 1 1
    WIPI1 AKT1 0 0 293 336 1 2
    WIPI1 BHMT 0 0 102 163 1 1
    WIPI1 TTL 0 0 0 156 1 1
    WIPI1 ALS2CL 0 0 205 528 1 1
    WIPI1 CHMP2A 0 0 97 220 1 2
    WIPI1 WDR45B 0 0 901 392 1 1
    WIPI1 WIPI2 0 800 901 808 1 2
    WIPI1 FIS1 0 0 270 322 1 2
    WIPI1 UBL3 0 0 0 302 1 1
    WIPI1 HIPK3 0 0 45 160 1 1
    WIPI1 CASP2 0 0 71 191 1 1
    WIPI1 MTMR1 0 0 73 173 1 1
    WIPI1 ECHDC2 0 0 0 178 1 1
    WIPI1 MTMR11 0 0 0 153 1 1
    WIPI1 SACM1L 0 0 325 562 1 1
    WIPI1 VPS11 0 0 324 411 1 2
    WIPI1 CNPPD1 0 0 0 161 1 1
    WIPI1 TECPR2 0 0 321 321 1 2
    WIPI1 NBR1 0 0 518 676 1 2
    WIPI1 DNAJC6 0 0 57 264 1 1
    WIPI1 WDR45 0 0 901 429 1 2
    WIPI1 IGF1 0 0 194 194 1 1
    WIPI1 WDFY3 0 0 469 585 1 2
    WIPI1 UVRAG 0 0 681 736 1 2
    WIPI1 SEC61A2 0 0 143 229 1 1
    WIPI1 CCPG1 0 0 172 203 1 1
    WIPI1 PPP6R1 0 0 0 198 1 1
    WIPI1 PFKFB4 0 0 0 192 1 1
    WIPI1 WDR46 0 0 0 261 1 1
    WIPI1 RHBDL1 0 0 0 208 1 1
    WIPI1 FNBP1L 0 0 69 279 1 1
    WIPI1 RAB7A 0 0 519 723 1 2
    WIPI1 LACRT 0 0 167 438 1 1
    WIPI1 DRAM1 0 0 422 464 1 2
    WIPI1 SOS1 0 0 0 181 1 1
    WIPI1 ATG4B 0 0 562 819 1 2
    WIPI1 ATP12A 0 0 150 192 1 1
    WIPI1 PIK3C2G 0 0 92 173 1 1
    WIPI1 PPP6R3 0 0 0 198 1 1
    WIPI1 TFRC 0 0 82 151 1 1
    WIPI1 HNRNPA3 272 0 0 283 1 1
    WIPI1 ULK3 0 0 217 615 1 2
    WIPI1 PRKAA1 0 0 162 279 1 2
    WIPI1 HERC3 0 0 90 178 1 1
    WIPI1 GLYR1 0 0 90 186 1 1
    WIPI1 EPG5 0 0 456 660 1 2
    WIPI1 RALGPS2 0 0 0 164 1 1
    WIPI1 SGK1 0 0 78 193 1 1
    WIPI1 PIK3C2B 0 0 140 216 1 1
    WIPI1 LIPA 0 0 81 151 1 1
    WIPI1 STBD1 0 0 142 195 1 2
    WIPI1 EIF4E 0 0 146 153 1 1
    WIPI1 CHMP4B 0 0 171 192 1 2
    WIPI1 TP53INP2 0 0 180 179 1 2
    WIPI1 RPS6KB1 0 0 294 382 1 2
    WIPI1 YWHAQ 0 0 53 158 1 1
    WIPI1 DNAJB7 0 0 0 150 1 1
    WIPI1 EPN3 0 0 60 162 1 1
    WIPI1 CHMP1A 0 0 95 207 1 1
    WIPI1 CANX 0 0 163 248 1 2
    WIPI1 ATG2A 62 800 865 994 1 2
    WIPI1 LCP1 0 0 0 216 1 1
    WIPI1 SIDT1 0 0 108 156 1 1
    WIPI1 BCL2 0 0 88 187 1 2
    WIPI1 ECHDC1 0 0 0 309 1 1
    WIPI1 RHEB 0 0 358 396 1 2
    WIPI1 TBC1D17 0 0 206 416 1 1
    WIPI1 DNAJB2 0 0 0 150 1 1
    WIPI1 DNAJB12 0 0 0 150 1 1
    WIPI1 PIP5KL1 0 0 0 211 1 1
    WIPI1 MAD2L2 0 0 151 225 1 1
    WIPI1 GNB2L1 292 0 108 341 1 1
    WIPI1 TECPR1 0 800 501 896 1 2
    WIPI1 MAPK14 0 0 136 208 1 1
    WIPI1 NBEAL2 0 0 0 171 1 1
    WIPI1 GOPC 0 0 94 184 1 2
    WIPI1 WSB2 0 0 0 279 1 1
    WIPI1 FAM134B 0 0 224 224 1 1
    WIPI1 BAG1 0 0 226 225 1 2
    WIPI1 KERA 0 0 0 158 1 1
    WIPI1 AMBRA1 0 0 651 664 1 2
    WIPI1 MAP3K3 0 0 46 170 1 1
    WIPI1 AIPL1 0 0 0 213 1 1
    WIPI1 PI4KB 0 0 134 211 1 1
    WIPI1 RHBDL2 0 0 0 207 1 1
    WIPI1 DNM1L 0 0 246 328 1 2
    WIPI1 KIAA0226 0 0 459 543 1 1
    WIPI1 SEC24A 0 0 85 282 1 1
    WIPI1 PRKAA2 0 0 160 277 1 2
    WIPI1 GABARAP 0 0 687 857 1 2
    WIPI1 ACSL4 0 0 46 158 1 1
    WIPI1 ENSG00000260836 0 0 0 154 1 1
    WIPI1 SOGA1 0 0 122 165 1 2
    WIPI1 FEZ1 0 0 171 171 1 1
    WIPI1 NBEAL1 0 0 0 171 1 1
    WIPI1 MAEA 0 0 0 152 1 1
    WIPI1 PTEN 0 0 245 392 1 2
    WIPI1 VPS26B 0 0 0 157 1 1
    WIPI1 FMN1 0 0 0 452 1 1
    WIPI1 TRAPPC2P1 0 0 120 157 1 1
    WIPI1 ATP6V0A1 0 0 181 248 1 1
    WIPI1 FLT3 209 0 0 223 1 1
    WIPI1 SNX30 0 0 0 500 1 1
    WIPI1 PPP1R15B 0 0 66 163 1 1
    WIPI1 ATG7 0 0 779 931 1 2
    WIPI1 SLC44A1 0 0 57 188 1 1
    WIPI1 DNAJB13 0 0 0 195 1 1
    WIPI1 ENDOD1 0 0 203 203 1 1
    WIPI1 ARSJ 0 0 166 263 1 1
    WIPI1 CTSD 0 0 273 321 1 2
    WIPI1 PREB 0 0 181 235 1 1
    WIPI1 AMPH 0 0 101 150 1 1
    WIPI1 M6PR 0 0 607 607 1 1
    WIPI1 STX12 0 0 0 199 1 1
    WIPI1 COL4A3BP 0 0 122 299 1 1
    WIPI1 DAP 0 0 270 288 1 2
    WIPI1 VTI1B 0 0 251 293 1 2
    WIPI1 TUBGCP2 0 0 72 166 1 1
    WIPI1 TOMM70A 0 0 66 166 1 1
    WIPI1 SEC61B 0 0 0 208 1 1
    WIPI1 TFF2 296 0 0 296 1 1
    WIPI1 PIP4K2C 0 0 0 211 1 1
    WIPI1 PAQR3 0 0 0 170 1 2
    WIPI1 DNAJB8 0 0 0 150 1 1
    WIPI1 TBC1D14 0 0 142 163 1 2
    WIPI1 NUDCD3 0 0 0 167 1 1
    WIPI1 NUDC 0 0 457 574 1 1
    WIPI1 ULK1 0 0 896 949 1 2
    WIPI1 STX7 0 0 61 186 1 2
    WIPI1 MAP1LC3B 0 0 559 737 1 2
    WIPI1 WDR43 0 0 81 286 1 1
    WIPI1 AGFG1 0 0 235 251 1 1
    WIPI1 SNAP91 0 0 108 198 1 1
    WIPI1 WDFY4 0 0 0 251 1 1
    WIPI1 MTMR8 0 0 0 189 1 1
    WIPI1 TXNL4B 0 0 67 210 1 1
    WIPI1 USP30 0 0 284 312 1 1
    WIPI1 VAMP3 0 0 81 166 1 1
    WIPI1 CPEB1 0 0 0 154 1 1
    WIPI1 ATG10 0 0 710 830 1 2
    WIPI1 DNASE2B 303 0 0 318 1 1
    WIPI1 XBP1 0 900 241 923 1 2
    WIPI1 MIB1 0 0 0 329 1 1
    WIPI1 ATP4A 0 0 150 192 1 1
    WIPI1 CALCOCO2 0 0 600 600 1 2
    WIPI1 ATG5 0 0 831 938 1 2
    WIPI1 CAMK1 0 0 66 321 1 1
    WIPI1 PDK4 0 0 0 167 1 1
    WIPI1 OPTN 0 0 529 541 1 2
    WIPI1 UBQLN2 0 0 166 201 1 2
    WIPI1 ESR1 270 0 297 464 1 1
    WIPI1 HMGB1 0 0 96 153 1 2
    WIPI1 PPA1 71 0 64 264 1 1
    WIPI1 PDIK1L 0 0 0 458 1 1
    WIPI1 GPR89A 0 0 0 183 1 1
    WIPI1 CTSB 0 0 256 314 1 2
    WIPI1 OSBP 0 0 181 200 1 1
    WIPI1 INPP4A 0 0 164 163 1 1
    WIPI1 SIRT1 0 0 211 216 1 2
    WIPI1 ECI1 0 0 0 178 1 1
    WIPI1 ENSG00000100926 0 0 228 348 1 1
    WIPI1 BECN1 210 0 803 943 1 2
    WIPI1 OTUD7B 0 0 913 913 1 1
    WIPI1 MOGAT2 0 0 73 167 1 1
    WIPI1 DNAJB6 0 0 0 150 1 1
    WIPI1 ADCY10 0 0 134 155 1 1
    WIPI1 SCAMP5 0 0 81 235 1 1
    WIPI1 MTMR12 0 0 66 175 1 1
    WIPI1 SNX4 0 0 134 413 1 1
    WIPI1 PEX3 0 0 302 302 1 2
    WIPI1 VAC14 0 0 918 965 1 1
    WIPI1 HPS4 0 0 92 185 1 1
    WIPI1 AUH 0 0 0 178 1 1
    WIPI1 PIK3CB 0 0 102 182 1 1
    WIPI1 LRRK2 0 0 218 286 1 2
    WIPI1 ATXN3 0 0 160 160 1 1
    WIPI1 PFKFB1 0 0 0 192 1 1
    WIPI1 ESYT3 0 0 160 193 1 1
    WIPI1 SEC62 0 0 166 165 1 1
    WIPI1 ATP6V0A4 0 0 181 248 1 1
    WIPI1 SIGMAR1 0 0 49 164 1 1
    WIPI1 NOD1 0 0 134 162 1 1
    WIPI1 DNAJB9 0 0 146 297 1 2
    WIPI1 YWHAZ 0 0 0 172 1 1
    WIPI1 MON1A 0 0 48 243 1 1
    WIPI1 SPINK13 0 0 126 158 1 1
    WIPI1 DEPTOR 0 0 248 248 1 1
    WIPI1 RRAGC 0 0 216 234 1 1
    WIPI1 MTMR9 0 0 97 203 1 1
    WIPI1 SLC44A5 0 0 0 175 1 1
    WIPI1 DNM1 0 0 112 209 1 1
    WIPI1 PKP1 169 0 0 254 1 1
    WIPI1 HSPA5 0 0 123 185 1 2
    WIPI1 TFE3 0 0 218 449 1 1
    WIPI1 TBC1D25 0 0 90 220 1 1
    WIPI1 SNX2 0 0 203 460 1 1
    WIPI1 MLST8 0 0 289 364 1 2
    WIPI1 TPTE2 0 0 0 215 1 1
    WIPI1 BABAM1 0 0 0 190 1 1
    WIPI1 PRCC 0 0 60 158 1 1
    WIPI1 PI4K2A 0 0 161 251 1 1
    WIPI1 CDKN2A 0 0 113 157 1 2
    WIPI1 GSK3B 0 0 49 189 1 2
    WIPI1 ATP6V1C1 0 0 142 213 1 1
    WIPI1 USF2 0 0 0 223 1 1
    WIPI1 CUL3 0 0 84 191 1 1
    WIPI1 PI4KA 0 0 96 222 1 1
    WIPI1 NOD2 0 0 165 165 1 1
    WIPI1 ATG16L1 0 800 837 979 1 2
    WIPI1 CCDC141 0 0 157 156 1 1
    WIPI1 LAMTOR1 0 0 87 459 1 1
    WIPI1 PHB2 0 0 134 267 1 1
    WIPI1 RIPK1 0 0 90 168 1 1
    WIPI1 HDAC1 0 0 345 345 1 2
    WIPI1 NBEA 0 0 0 215 1 1
    WIPI1 ATG4D 0 0 503 746 1 2
    WIPI1 PLEKHM1 0 0 335 362 1 2
    WIPI1 OS9 0 0 125 215 1 1
    WIPI1 ATG101 0 0 838 908 1 2
    WIPI1 ATP6V1B2 0 0 81 209 1 1
    WIPI1 DNAJC22 0 0 0 150 1 1
    WIPI1 CDC27 0 0 0 152 1 1
    WIPI1 CASP3 0 0 165 252 1 2
    WIPI1 RASGRP4 0 0 0 164 1 1
    WIPI1 VPS29 0 0 66 166 1 1
    WIPI1 LCN1 0 0 0 187 1 1
    WIPI1 SMURF1 0 0 193 259 1 1
    WIPI1 STX16 0 0 0 250 1 1
    WIPI1 UBA2 0 0 0 339 1 1
    WIPI1 NOLC1 0 0 88 150 1 1
    WIPI1 CTSS 0 0 167 182 1 1
    WIPI1 VPS13A 0 0 193 246 1 1
    WIPI1 RASGRF1 0 0 0 164 1 1
    WIPI1 ATG12 160 0 884 968 1 2
    WIPI1 KLHL20 0 0 124 217 1 1
    WIPI1 ISYNA1 0 0 0 151 1 1
    WIPI1 ENSG00000268643 0 0 0 183 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0050681 Molecular Function nuclear androgen receptor binding enables IDA
    GO:0030331 Molecular Function nuclear estrogen receptor binding enables IDA
    GO:0080025 Molecular Function phosphatidylinositol-3,5-bisphosphate binding enables IBA
    GO:0080025 Molecular Function phosphatidylinositol-3,5-bisphosphate binding enables IDA
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IBA
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IBA
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IDA
    GO:0005102 Molecular Function signaling receptor binding enables IDA
    GO:0000045 Biological Process autophagosome assembly involved_in IMP
    GO:0006914 Biological Process autophagy involved_in IEP
    GO:0000422 Biological Process autophagy of mitochondrion involved_in IBA
    GO:0009267 Biological Process cellular response to starvation involved_in IDA
    GO:0061723 Biological Process glycophagy involved_in IBA
    GO:0044804 Biological Process nucleophagy involved_in IBA
    GO:0000425 Biological Process pexophagy involved_in IBA
    GO:2000786 Biological Process positive regulation of autophagosome assembly involved_in IDA
    GO:0034497 Biological Process protein localization to phagophore assembly site involved_in IBA
    GO:0048203 Biological Process vesicle targeting, trans-Golgi to endosome involved_in IDA
    GO:0000139 Cellular Component Golgi membrane located_in TAS
    GO:0000421 Cellular Component autophagosome membrane located_in IDA
    GO:0030136 Cellular Component clathrin-coated vesicle located_in IEA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005856 Cellular Component cytoskeleton located_in IEA
    GO:0005829 Cellular Component cytosol is_active_in IBA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0010008 Cellular Component endosome membrane located_in IDA
    GO:0000407 Cellular Component phagophore assembly site located_in IDA
    GO:0034045 Cellular Component phagophore assembly site membrane is_active_in IBA
    GO:0034045 Cellular Component phagophore assembly site membrane located_in IDA
    GO:0005802 Cellular Component trans-Golgi network located_in IDA
    Pathways
    Name DB ID
    Macroautophagy Reactome R-HSA-1632852
    Cellular responses to stress Reactome R-HSA-2262752
    XBP1(S) activates chaperone genes Reactome R-HSA-381038
    IRE1alpha activates chaperones Reactome R-HSA-381070
    Unfolded Protein Response (UPR) Reactome R-HSA-381119
    Cellular responses to stimuli Reactome R-HSA-8953897
    Autophagy Reactome R-HSA-9612973
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    Host-pathogen interaction of human coronaviruses - autophagy (WP4863) WikiPathways WP4863_r124639
    Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (WP4577) WikiPathways WP4577_r123500
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_135471 2 miscRNA transcript variant 4 NC_000017 Reference
    NR_135470 2 miscRNA transcript variant 3 NC_000017 Reference
    NM_001320772 2 mRNA transcript variant 2 NC_000017 Reference
    NM_017983 7 mRNA transcript variant 1 NC_000017 Reference
    XM_017024808 2 mRNA transcript variant X1 NC_000017 Reference