HAdb 2.0 is available now!

LAPTM4B

lysosomal protein transmembrane 4 beta
General Information
Name lysosomal protein transmembrane 4 beta
Alias
  • lysosomal-associated transmembrane protein 4B
  • lysosomal associated protein transmembrane 4 beta
  • lysosome-associated transmembrane protein 4-beta
Gene_family
organism Homo sapiens
entrez_id 55353
location 8q22.1
transcript_count 1
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...]
    nextProt Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
LAPTM4B BioGRID NRROS GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID SLCO6A1 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID ANKRD22 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID PCDHAC2 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID RETREG1 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID IL20RA GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID PCDHB1 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID LYPD3 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID HCST GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID KCNE3 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID DGCR2 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID TMEM59 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID TNFRSF10B GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID TNFRSF10C GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID DLK1 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID TGFA GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID CX3CL1 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID TSPAN31 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID KIR2DL4 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID SLC22A2 GeneID BioGRID PCA
LAPTM4B BioGRID SLC22A1 GeneID BioGRID PCA
LAPTM4B BioGRID BDKRB1 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID CTXN3 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID GPX8 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID TRARG1 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID TMEM86B GeneID BioGRID Two-hybrid
LAPTM4B BioGRID CYB561A3 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID MTIF3 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID ODF4 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID ISLR2 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID CGRRF1 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID IGFBP5 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID IFNAR1 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID SLC29A2 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID NRG1 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID GJA8 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID EMP1 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID SCARB2 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID TMEM231 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID ENTPD7 GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID TNFRSF10A GeneID BioGRID Affinity Capture-MS
LAPTM4B BioGRID SNX5 GeneID BioGRID Affinity Capture-Western
LAPTM4B BioGRID PIP5K1C GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
LAPTM4B BioGRID HGS GeneID BioGRID Affinity Capture-Western
LAPTM4B BioGRID NEDD4 GeneID BioGRID Affinity Capture-Western
LAPTM4B BioGRID NAALADL2 GeneID BioGRID Two-hybrid
LAPTM4B BioGRID TFRC GeneID BioGRID Affinity Capture-Western
StringDB
A B experiments database textmining combined score hadb nhadb
LAPTM4B ETFB 0 0 112 205 1 1
LAPTM4B CEBPE 0 0 70 167 1 1
LAPTM4B GABARAPL1 0 0 104 197 1 2
LAPTM4B RGS14 0 0 107 210 1 1
LAPTM4B SAR1A 0 0 115 255 1 1
LAPTM4B AKAP1 0 0 44 192 1 1
LAPTM4B PLEKHF2 0 0 181 368 1 1
LAPTM4B RAB1A 0 0 57 156 1 1
LAPTM4B KCNS2 0 0 195 406 1 1
LAPTM4B PMCH 0 0 135 165 1 1
LAPTM4B TBC1D7 0 0 113 164 1 2
LAPTM4B SLC38A2 0 0 162 219 1 1
LAPTM4B KIAA1324 0 0 157 156 1 1
LAPTM4B RIN1 0 0 411 410 1 1
LAPTM4B ATP6V1C1 0 0 218 242 1 1
LAPTM4B B4GALT5 0 0 151 295 1 1
LAPTM4B BTBD3 0 0 157 300 1 1
LAPTM4B TRIM44 0 0 108 262 1 1
LAPTM4B GTF2E1 0 0 159 234 1 1
LAPTM4B SOCS2 0 0 181 263 1 1
LAPTM4B ZFAT 0 0 155 154 1 1
LAPTM4B BMPR1B 0 0 0 159 1 1
LAPTM4B MAGEA6 0 0 137 156 1 1
LAPTM4B GATSL3 0 0 304 314 1 1
LAPTM4B GPX8 113 0 0 165 1 1
LAPTM4B RAD21 0 0 150 213 1 1
LAPTM4B CYBB 0 0 0 216 1 2
LAPTM4B SQSTM1 0 0 153 152 1 2
LAPTM4B BNIP3 0 0 108 183 1 2
LAPTM4B SLC16A1 0 0 90 237 1 1
LAPTM4B GGA3 0 0 162 219 1 1
LAPTM4B ARID4B 0 0 0 248 1 1
LAPTM4B ZCCHC2 0 0 62 157 1 1
LAPTM4B HIST1H2BG 0 0 74 153 1 1
LAPTM4B CPPED1 0 0 171 321 1 1
LAPTM4B NME2 0 0 124 219 1 1
LAPTM4B CDC42EP3 0 0 91 197 1 1
LAPTM4B EXOC3 270 0 82 301 1 1
LAPTM4B HEATR6 0 0 103 344 1 1
LAPTM4B PHACTR2 0 0 160 264 1 1
LAPTM4B ATG13 0 0 154 155 1 2
LAPTM4B ASAH1 0 0 234 234 1 1
LAPTM4B TNFRSF10B 660 0 0 660 1 2
LAPTM4B NCAPG 0 0 122 160 1 1
LAPTM4B ACTB 0 0 206 223 1 2
LAPTM4B SLC1A1 0 0 0 231 1 1
LAPTM4B METTL5 0 0 241 240 1 1
LAPTM4B ABCA4 0 0 86 164 1 1
LAPTM4B AFP 0 0 166 209 1 2
LAPTM4B UGCG 0 0 66 166 1 1
LAPTM4B SLC16A9 0 0 0 150 1 1
LAPTM4B LRRC3 0 0 0 465 1 1
LAPTM4B MRPS21 0 0 167 167 1 1
LAPTM4B RNF152 0 0 134 157 1 1
LAPTM4B ATG4D 0 0 108 201 1 2
LAPTM4B TFEB 0 0 154 169 1 2
LAPTM4B HSP90AA1 0 0 0 162 1 2
LAPTM4B ATG101 0 0 126 161 1 2
LAPTM4B GOLGB1 0 0 125 227 1 1
LAPTM4B RMND5B 0 0 181 181 1 1
LAPTM4B FRRS1 0 0 178 177 1 1
LAPTM4B C1orf141 0 0 213 213 1 1
LAPTM4B LFNG 0 0 83 177 1 1
LAPTM4B CD109 0 0 150 172 1 1
LAPTM4B RRAGD 0 0 208 213 1 1
LAPTM4B TCTEX1D2 0 0 165 165 1 1
LAPTM4B POTEH 0 0 234 250 1 1
LAPTM4B KCNB2 0 0 100 199 1 1
LAPTM4B SAR1B 0 0 0 193 1 1
LAPTM4B EMC1 0 0 158 527 1 1
LAPTM4B SPTLC3 0 0 144 229 1 1
LAPTM4B PLS1 0 0 117 225 1 1
LAPTM4B TM9SF2 0 0 216 515 1 1
LAPTM4B MET 270 0 141 385 1 2
LAPTM4B INTS8 0 0 161 161 1 1
LAPTM4B BECN1 0 0 468 479 1 2
LAPTM4B FAM91A1 0 0 210 210 1 1
LAPTM4B NAP1L4 0 0 122 321 1 1
LAPTM4B ABCB1 270 0 61 303 1 2
LAPTM4B DTX1 0 0 0 188 1 1
LAPTM4B ATP6V0E1 0 0 184 183 1 1
LAPTM4B TMEM231 498 0 0 497 1 1
LAPTM4B TM9SF4 0 0 113 249 1 1
LAPTM4B NCOA3 0 0 325 325 1 1
LAPTM4B MMP2 0 0 160 185 1 2
LAPTM4B ZFP91 0 0 136 268 1 1
LAPTM4B EI24 0 0 150 181 1 2
LAPTM4B ZNF706 0 0 213 213 1 1
LAPTM4B PUM2 0 0 83 320 1 1
LAPTM4B UNC50 0 0 123 263 1 1
LAPTM4B FER 0 0 0 324 1 1
LAPTM4B LRRC32 0 0 460 460 1 1
LAPTM4B PPL 0 0 54 272 1 1
LAPTM4B C16orf62 0 0 0 226 1 1
LAPTM4B EXOC7 270 0 432 567 1 1
LAPTM4B FAM84B 0 0 154 185 1 1
LAPTM4B IRS2 0 0 296 296 1 1
LAPTM4B WDR35 0 0 91 339 1 1
LAPTM4B PTAR1 0 0 157 195 1 1
LAPTM4B GTPBP4 0 0 0 426 1 1
LAPTM4B MMP24 0 0 135 166 1 1
LAPTM4B NCOA4 0 0 62 177 1 2
LAPTM4B SLC43A1 0 0 86 181 1 1
LAPTM4B ZNF813 0 0 288 288 1 1
LAPTM4B DTX4 0 0 113 248 1 1
LAPTM4B BSPRY 0 0 188 271 1 1
LAPTM4B FOS 0 0 167 167 1 2
LAPTM4B FAM83B 0 0 203 232 1 1
LAPTM4B CCL27 0 0 359 359 1 1
LAPTM4B YWHAZ 0 0 605 614 1 1
LAPTM4B PHC2 0 0 113 204 1 1
LAPTM4B LAMP2 0 0 200 200 1 2
LAPTM4B YWHAE 0 0 359 392 1 1
LAPTM4B TGFBR1 0 0 0 159 1 1
LAPTM4B GRINA 0 0 155 154 1 1
LAPTM4B GPR56 0 0 173 298 1 1
LAPTM4B SLC10A5 0 0 193 193 1 1
LAPTM4B DCAF15 0 0 181 495 1 1
LAPTM4B MATN3 0 0 143 518 1 1
LAPTM4B MAP1LC3B 0 0 170 169 1 2
LAPTM4B SDC2 0 0 127 158 1 1
LAPTM4B TEAD4 0 0 60 158 1 1
LAPTM4B TTK 0 0 134 167 1 1
LAPTM4B LRRC42 0 0 263 281 1 1
LAPTM4B HSDL2 0 0 151 171 1 1
LAPTM4B SESN2 0 0 170 203 1 2
LAPTM4B STMN1 0 0 56 153 1 1
LAPTM4B MAPKAPK3 0 0 142 294 1 1
LAPTM4B ACVRL1 0 0 0 159 1 1
LAPTM4B RAB38 0 0 95 151 1 1
LAPTM4B ULK1 0 0 180 185 1 2
LAPTM4B ATP6AP1 0 0 180 254 1 1
LAPTM4B KCNS3 0 0 0 167 1 1
LAPTM4B SEC61G 0 0 0 355 1 1
LAPTM4B SH3BP5L 0 0 201 201 1 1
LAPTM4B DYNLL2 0 0 0 302 1 1
LAPTM4B SNX5 270 0 194 386 1 1
LAPTM4B SPTSSA 0 0 165 183 1 1
LAPTM4B TSPYL5 0 0 233 249 1 1
LAPTM4B PHF20L1 0 0 181 268 1 1
LAPTM4B PTDSS2 0 0 0 290 1 1
LAPTM4B FKTN 0 0 91 151 1 1
LAPTM4B HIST1H2AD 0 0 166 165 1 1
LAPTM4B DLK1 219 0 0 219 1 1
LAPTM4B SQLE 0 0 166 225 1 1
LAPTM4B TMEM55B 0 0 158 157 1 1
LAPTM4B FLCN 0 0 187 442 1 1
LAPTM4B GULP1 0 0 115 221 1 1
LAPTM4B SLC1A2 0 0 0 240 1 1
LAPTM4B ATG4A 0 0 167 172 1 2
LAPTM4B ACKR2 0 0 327 327 1 1
LAPTM4B FMNL2 0 0 0 213 1 1
LAPTM4B SLC22A1 191 0 0 191 1 1
LAPTM4B PTDSS1 0 0 293 645 1 1
LAPTM4B NXPH2 0 0 232 587 1 1
LAPTM4B PPP2R2C 0 0 113 203 1 1
LAPTM4B LAPTM5 0 800 402 839 1 1
LAPTM4B ANGEL1 0 0 231 396 1 1
LAPTM4B ATG5 0 0 172 171 1 2
LAPTM4B NIPSNAP1 0 0 150 191 1 1
LAPTM4B CLDN6 0 0 112 155 1 1
LAPTM4B MAMDC2 0 0 144 292 1 1
LAPTM4B YAP1 0 0 0 189 1 2
LAPTM4B AP4E1 0 0 132 223 1 1
LAPTM4B ACVR1 0 0 0 159 1 1
LAPTM4B CTSH 0 0 72 215 1 1
LAPTM4B ARL6IP5 0 0 113 206 1 1
LAPTM4B NAALADL2 309 0 0 323 1 1
LAPTM4B PIK3R1 270 0 770 825 1 1
LAPTM4B UFM1 0 0 107 309 1 1
LAPTM4B SMIM24 0 0 466 641 1 1
LAPTM4B GABARAP 0 0 92 167 1 2
LAPTM4B DSCC1 0 0 112 181 1 1
LAPTM4B SEC22C 0 0 91 162 1 1
LAPTM4B DUSP9 0 0 0 154 1 1
LAPTM4B ELAVL1 0 0 0 177 1 2
LAPTM4B BMPR1A 0 0 0 179 1 1
LAPTM4B MCM4 0 0 107 174 1 1
LAPTM4B SLC22A2 191 0 0 191 1 1
LAPTM4B TMEM86A 0 0 235 635 1 1
LAPTM4B KIAA0226 0 0 241 240 1 1
LAPTM4B C7orf34 0 0 264 264 1 1
LAPTM4B ISLR2 497 0 0 497 1 1
LAPTM4B PLS3 0 0 0 163 1 1
LAPTM4B PIP5K1C 270 0 0 270 1 1
LAPTM4B LENEP 0 0 231 230 1 1
LAPTM4B GOLGA4 0 0 90 230 1 1
LAPTM4B KIT 0 0 65 161 1 2
LAPTM4B GGH 0 0 325 403 1 1
LAPTM4B ANP32D 0 0 0 187 1 1
LAPTM4B PDGFRB 270 0 453 626 1 2
LAPTM4B C8orf33 0 0 245 244 1 1
LAPTM4B FAM134B 425 0 0 424 1 1
LAPTM4B SLC36A4 0 0 123 201 1 1
LAPTM4B RERG 0 0 142 156 1 1
LAPTM4B PDGFRA 0 0 57 154 1 1
LAPTM4B TEAD1 0 0 0 152 1 1
LAPTM4B COL4A3BP 0 0 98 194 1 1
LAPTM4B SLC25A32 0 0 164 163 1 1
LAPTM4B NYNRIN 0 0 390 634 1 1
LAPTM4B MORF4L2 0 0 0 170 1 1
LAPTM4B CCR10 0 0 384 384 1 1
LAPTM4B GPR133 0 0 140 212 1 1
LAPTM4B MAPKAPK2 0 0 68 151 1 1
LAPTM4B DNAL4 0 0 0 179 1 1
LAPTM4B CDK6 0 0 108 201 1 2
LAPTM4B RHOB 0 0 0 162 1 1
LAPTM4B ZNF707 0 0 0 193 1 1
LAPTM4B ACTG1 0 0 127 163 1 1
LAPTM4B CPTP 0 0 134 264 1 1
LAPTM4B SLC35F2 0 0 172 182 1 1
LAPTM4B CNPY2 0 0 340 340 1 1
LAPTM4B AANAT 0 0 603 603 1 1
LAPTM4B MTDH 0 0 282 282 1 2
LAPTM4B FGFR4 0 0 0 165 1 1
LAPTM4B NIPSNAP3B 0 0 215 264 1 1
LAPTM4B CDK2AP1 0 0 108 185 1 1
LAPTM4B PKDREJ 0 0 182 266 1 1
LAPTM4B PKIG 0 0 202 202 1 1
LAPTM4B SLC3A2 0 0 750 750 1 1
LAPTM4B ATG16L2 0 0 97 159 1 2
LAPTM4B EXOC4 270 0 76 296 1 1
LAPTM4B NPM1 0 0 135 188 1 1
LAPTM4B FLT3 0 0 73 168 1 2
LAPTM4B STBD1 0 0 141 234 1 1
LAPTM4B FGFR3 0 0 0 165 1 1
LAPTM4B TFAP4 0 0 324 393 1 1
LAPTM4B LAMP1 0 0 155 189 1 2
LAPTM4B MOGAT1 0 0 108 169 1 1
LAPTM4B EGFR 270 0 985 989 1 2
LAPTM4B FES 0 0 0 443 1 1
LAPTM4B ARHGAP22 0 0 292 488 1 1
LAPTM4B FAM46A 0 0 134 223 1 1
LAPTM4B TMEM159 0 0 304 439 1 1
LAPTM4B CKS1B 0 0 90 616 1 1
LAPTM4B ATP6V0C 0 0 126 259 1 1
LAPTM4B STX2 0 0 61 205 1 1
LAPTM4B SLC7A5 0 0 687 695 1 1
LAPTM4B SERPINA4 0 0 135 169 1 1
LAPTM4B CDK5RAP2 0 0 99 155 1 1
LAPTM4B MMRN1 0 0 300 427 1 1
LAPTM4B MPP7 0 0 260 368 1 1
LAPTM4B RALGAPA1 0 0 160 308 1 1
LAPTM4B NELL2 0 0 95 185 1 1
LAPTM4B CCND1 0 0 150 200 1 2
LAPTM4B BHLHE22 0 0 46 266 1 1
LAPTM4B CISD2 0 0 107 199 1 2
LAPTM4B TRPS1 0 0 122 176 1 1
LAPTM4B TP53I3 0 0 95 151 1 1
LAPTM4B HGS 270 0 0 270 1 2
LAPTM4B SPRY1 0 0 0 213 1 1
LAPTM4B ANKRD10 0 0 217 217 1 1
LAPTM4B NGFRAP1 0 0 283 621 1 1
LAPTM4B ITSN1 0 0 74 167 1 1
LAPTM4B RHEB 0 0 113 188 1 2
LAPTM4B EXOC2 0 0 911 911 1 1
LAPTM4B SLC5A1 0 0 141 172 1 1
LAPTM4B SNX22 0 0 203 203 1 1
LAPTM4B MAP4K3 0 0 57 221 1 1
LAPTM4B B4GALT6 0 0 0 204 1 1
LAPTM4B LACTB2 0 0 203 203 1 1
LAPTM4B VDAC2 0 0 59 234 1 1
LAPTM4B EMP1 92 0 241 441 1 1
LAPTM4B A4GNT 0 0 0 207 1 1
LAPTM4B TMEM165 0 0 193 497 1 1
LAPTM4B ARID4A 0 0 0 248 1 1
LAPTM4B SUSD3 0 0 193 338 1 1
LAPTM4B MCOLN1 0 0 167 483 1 2
LAPTM4B DYNLL1 0 0 122 483 1 1
LAPTM4B LARS 0 0 207 301 1 1
LAPTM4B SCARB2 272 0 0 273 1 1
LAPTM4B CKS2 0 0 0 404 1 1
LAPTM4B LAPTM4A 0 800 770 819 1 1
LAPTM4B CPQ 0 0 254 541 1 1
LAPTM4B CDK12 0 0 194 194 1 1
LAPTM4B YBX1 0 0 124 156 1 1
LAPTM4B SLC39A6 0 0 243 257 1 1
LAPTM4B MATN2 0 0 293 309 1 1
LAPTM4B ARL8B 0 0 181 213 1 1
LAPTM4B ECHDC2 0 0 159 195 1 1
LAPTM4B SLC1A3 0 0 0 216 1 1
LAPTM4B SLC25A12 0 0 100 198 1 1
LAPTM4B MYC 0 0 218 218 1 2
LAPTM4B LGMN 0 0 126 187 1 1
LAPTM4B SLC1A6 0 0 0 240 1 1
LAPTM4B SLC1A5 0 0 134 245 1 1
LAPTM4B CARF 0 0 181 327 1 1
LAPTM4B NME1 0 0 54 153 1 1
LAPTM4B GOLGA7 0 0 0 161 1 1
LAPTM4B TPX2 0 0 134 199 1 1
LAPTM4B AP4M1 0 0 108 202 1 1
LAPTM4B GLIPR2 0 0 81 389 1 2
LAPTM4B AP3S1 0 0 168 167 1 1
LAPTM4B ABCA2 0 0 57 186 1 1
LAPTM4B LAMTOR3 0 0 170 246 1 1
LAPTM4B PIK3C2G 0 0 91 158 1 1
LAPTM4B ENTHD2 0 0 212 334 1 1
LAPTM4B CD63 0 0 94 154 1 2
LAPTM4B TFRC 270 0 95 338 1 1
LAPTM4B SPRY2 0 0 0 347 1 1
LAPTM4B AZIN1 0 0 184 183 1 1
LAPTM4B IFNAR1 241 0 0 240 1 1
LAPTM4B NFE2L3 0 0 90 152 1 1
LAPTM4B ANP32A 0 0 82 221 1 1
LAPTM4B CCL21 0 0 306 306 1 1
LAPTM4B PIP4K2A 0 0 150 185 1 1
LAPTM4B UNK 0 0 0 175 1 1
LAPTM4B A4GALT 0 0 44 209 1 1
LAPTM4B MYL9 0 0 0 189 1 1
LAPTM4B UVRAG 0 0 182 228 1 2
LAPTM4B SPRY3 0 0 0 213 1 1
LAPTM4B DDX53 0 0 243 242 1 1
LAPTM4B NOX3 0 0 0 155 1 1
LAPTM4B GPR160 0 0 157 156 1 1
LAPTM4B PKHD1L1 0 0 157 156 1 1
LAPTM4B ZBTB46 0 0 232 442 1 1
LAPTM4B TMEM86B 94 0 0 225 1 1
LAPTM4B PHF20 0 0 0 175 1 1
LAPTM4B PCDHA8 0 0 193 193 1 1
LAPTM4B UROD 0 0 90 185 1 1
LAPTM4B ARF1 0 0 107 183 1 1
LAPTM4B HSP90AB1 0 0 0 162 1 2
LAPTM4B ODF3B 0 0 204 204 1 1
LAPTM4B GBAS 0 0 149 238 1 1
LAPTM4B CNTN1 0 0 66 173 1 1
LAPTM4B NDUFB4 0 0 142 201 1 1
LAPTM4B ACVR1B 0 0 0 159 1 1
LAPTM4B ERBB2 0 0 258 280 1 2
LAPTM4B SLC38A9 0 0 393 599 1 1
LAPTM4B NBL1 0 0 0 171 1 1
LAPTM4B SERINC2 0 0 52 219 1 1
LAPTM4B DNMT3B 0 0 56 213 1 1
LAPTM4B AKT1 0 0 242 269 1 2
LAPTM4B PTP4A3 0 0 241 407 1 1
LAPTM4B ATP6V1C2 0 0 134 166 1 1
LAPTM4B FOXA1 0 0 141 166 1 1
LAPTM4B ACKR4 0 0 389 388 1 1
LAPTM4B FMNL3 0 0 0 213 1 1
LAPTM4B TGIF1 0 0 143 174 1 1
LAPTM4B SPATA45 0 0 320 319 1 1
LAPTM4B DAPL1 0 0 140 212 1 1
LAPTM4B RPLP2 0 0 54 266 1 1
LAPTM4B FGFR1 0 0 61 182 1 1
LAPTM4B SLC36A1 0 0 112 246 1 1
LAPTM4B CPXM1 0 0 405 533 1 1
LAPTM4B FGFR2 270 0 124 415 1 1
LAPTM4B ENO1 0 0 89 160 1 1
LAPTM4B SEMA6D 0 0 47 193 1 1
LAPTM4B CCDC91 0 0 146 277 1 1
LAPTM4B ATG14 0 0 257 261 1 2
LAPTM4B ANKS6 0 0 154 175 1 1
LAPTM4B LARS2 0 0 193 208 1 1
LAPTM4B LRRC3C 0 0 266 459 1 1
LAPTM4B C11orf58 0 0 156 155 1 1
LAPTM4B GAPDH 0 0 170 220 1 2
LAPTM4B SPRY4 0 0 0 259 1 1
LAPTM4B NAPG 0 0 48 179 1 1
LAPTM4B RALGAPA2 0 0 0 210 1 1
LAPTM4B NDFIP1 0 0 96 202 1 1
LAPTM4B WDR54 0 0 123 159 1 1
LAPTM4B ACVR1C 0 0 0 159 1 1
LAPTM4B AP1S3 0 0 161 167 1 1
LAPTM4B SLC1A7 0 0 280 285 1 1
LAPTM4B NDST3 0 0 140 178 1 1
LAPTM4B MAP7 0 0 109 179 1 1
LAPTM4B PAX2 0 0 291 290 1 1
LAPTM4B ATP6V1H 0 0 108 350 1 1
LAPTM4B KDR 0 0 0 156 1 2
LAPTM4B NEDD4 486 0 812 905 1 2
LAPTM4B SH3BP4 0 0 135 187 1 1
LAPTM4B RRAGA 0 0 184 190 1 1
LAPTM4B LYST 0 0 108 212 1 1
LAPTM4B STX17 0 0 134 173 1 2
LAPTM4B MROH1 0 0 94 150 1 1
LAPTM4B OR6K3 0 0 293 293 1 1
LAPTM4B CTNNB1 0 0 124 160 1 2
LAPTM4B AKR1C3 0 0 150 168 1 1
LAPTM4B APLP2 0 0 73 423 1 1
LAPTM4B APP 0 0 66 231 1 2
LAPTM4B PIP4K2B 0 0 134 157 1 1
LAPTM4B MTOR 0 0 206 206 1 2
LAPTM4B C1RL 0 0 155 213 1 1
LAPTM4B FMNL1 0 0 0 213 1 1
LAPTM4B RPL13A 0 0 85 241 1 1
LAPTM4B HRASLS2 0 0 204 204 1 1
LAPTM4B GOLGA7B 0 0 0 161 1 1
LAPTM4B WDR24 0 0 169 180 1 1
LAPTM4B CHRNA2 0 0 95 187 1 1
LAPTM4B ITGA6 0 0 454 468 1 1
LAPTM4B POTEF 0 0 140 158 1 1
LAPTM4B CCT3 0 0 0 214 1 1
LAPTM4B TUBA1C 0 0 112 162 1 1
LAPTM4B SLC16A10 0 0 134 234 1 1
LAPTM4B ATG4C 0 0 155 173 1 2
LAPTM4B ENSG00000270136 0 0 0 171 1 1
LAPTM4B FKBP15 0 0 144 267 1 1
LAPTM4B C11orf24 0 0 261 261 1 1
LAPTM4B ATG3 0 0 141 164 1 2
LAPTM4B HOXB6 0 0 73 215 1 1
LAPTM4B MYSM1 0 0 95 157 1 1
LAPTM4B PLOD3 0 0 141 227 1 1
LAPTM4B DENND2C 0 0 212 293 1 1
LAPTM4B PIK3C3 0 0 296 322 1 2
LAPTM4B LYPD3 228 0 0 227 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0097001 Molecular Function ceramide binding enables IDA
GO:0019900 Molecular Function kinase binding enables IPI
GO:1902936 Molecular Function phosphatidylinositol bisphosphate binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0031625 Molecular Function ubiquitin protein ligase binding enables IPI
GO:0007032 Biological Process endosome organization involved_in IMP
GO:0032509 Biological Process endosome transport via multivesicular body sorting pathway involved_in IDA
GO:1905166 Biological Process negative regulation of lysosomal protein catabolic process involved_in IMP
GO:0032911 Biological Process negative regulation of transforming growth factor beta1 production involved_in IDA
GO:0097213 Biological Process regulation of lysosomal membrane permeability involved_in IMP
GO:1905671 Biological Process regulation of lysosome organization involved_in IMP
GO:0042995 Cellular Component cell projection located_in IDA
GO:0005769 Cellular Component early endosome located_in IDA
GO:0005768 Cellular Component endosome located_in IDA
GO:0031902 Cellular Component late endosome membrane located_in IDA
GO:0005765 Cellular Component lysosomal membrane is_active_in IBA
GO:0005765 Cellular Component lysosomal membrane located_in IDA
GO:0005764 Cellular Component lysosome located_in IDA
GO:0032585 Cellular Component multivesicular body membrane located_in IDA
GO:0097487 Cellular Component multivesicular body, internal vesicle located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_018407 6 mRNA None NC_000008 Reference