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MEG3

maternally expressed 3
General Information
Name maternally expressed 3
Alias
  • Very putative protein from MEG3 locus
  • gene trap locus 2
  • long intergenic non-protein coding RNA 23
  • maternally expressed 3 (non-protein coding)
Gene_family Long non-coding RNAs with non-systematic symbols|MicroRNA non-coding host genes
organism Homo sapiens
entrez_id 55384
location 14q32.2
transcript_count 15
exon_count 13
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MEG3 BioGRID GSK3B GeneID BioGRID Affinity Capture-RNA; Protein-RNA
MEG3 BioGRID CTNNB1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
MEG3 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
MEG3 BioGRID STAT3 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
StringDB
A B experiments database textmining combined score hadb nhadb
Ontologies
ID Category Term Effect Evidence PubMed
GO:0035195 Biological Process miRNA-mediated post-transcriptional gene silencing involved_in IEA
GO:0030308 Biological Process negative regulation of cell growth involved_in IEA
GO:0016442 Cellular Component RISC complex part_of IEA
Pathways
Name DB ID
lncRNA-mediated mechanisms of therapeutic resistance (WP3672) WikiPathways WP3672_r123394
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_046467 1 ncRNA transcript variant 10 NC_000014 Reference
NR_046465 2 ncRNA transcript variant 8 NC_000014 Reference
NR_046472 1 ncRNA transcript variant 15 NC_000014 Reference
NR_046471 1 ncRNA transcript variant 14 NC_000014 Reference
NR_033359 1 ncRNA transcript variant 5 NC_000014 Reference
NR_003530 2 ncRNA transcript variant 2 NC_000014 Reference
NR_033358 1 ncRNA transcript variant 4 NC_000014 Reference
NR_002766 2 ncRNA transcript variant 1 NC_000014 Reference
NR_046470 2 ncRNA transcript variant 13 NC_000014 Reference
NR_033360 1 ncRNA transcript variant 6 NC_000014 Reference
NR_046464 1 ncRNA transcript variant 7 NC_000014 Reference
NR_046469 1 ncRNA transcript variant 12 NC_000014 Reference
NR_046466 1 ncRNA transcript variant 9 NC_000014 Reference
NR_046473 1 ncRNA transcript variant 16 NC_000014 Reference
NR_003531 3 ncRNA transcript variant 3 NC_000014 Reference