EIF2AK2

eukaryotic translation initiation factor 2 alpha kinase 2
General Information
Name eukaryotic translation initiation factor 2 alpha kinase 2
Alias
  • interferon-induced, double-stranded RNA-activated protein kinase
  • P1/eIF-2A protein kinase
  • double stranded RNA activated protein kinase
  • eIF-2A protein kinase 2
  • interferon-inducible elF2alpha kinase
  • p68 kinase
  • protein kinase R
  • protein kinase, interferon-inducible double stranded RNA dependent
  • protein phosphatase 1, regulatory subunit 83
  • tyrosine-protein kinase EIF2AK2
Synonyms PKR PPP1R83 DYT33 EIF2AK1 LEUDEN PRKR
Gene_family Protein phosphatase 1 regulatory subunits|Eukaryotic translation initiation factor 2 alpha kinases
organism Homo sapiens
entrez_id 5610
location 2p22.2
transcript_count 6
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
      Stringdb Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation fac [...]
      nextProt IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    EIF2AK2 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EIF2AK2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Cross-Linking-MS (XL-MS); FRET; Far Western; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID ATG5 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID N GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Protein-RNA; Two-hybrid
    EIF2AK2 BioGRID ORF6 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID ORF10 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID M GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID RPL7 GeneID BioGRID Cross-Linking-MS (XL-MS)
    EIF2AK2 BioGRID Hectd3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PPP1CA GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID TRIM21 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID MEN1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID Cebpb GeneID BioGRID Protein-peptide
    EIF2AK2 BioGRID HECTD1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ZNF24 GeneID BioGRID Cross-Linking-MS (XL-MS)
    EIF2AK2 BioGRID CEBPB GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID HSPA1A GeneID BioGRID Cross-Linking-MS (XL-MS)
    EIF2AK2 BioGRID ZNF346 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID G3BP1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID TNIP1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID UBE2H GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ANLN GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID KAT6A GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPA2 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID GRM2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SPOP GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MYC GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    EIF2AK2 BioGRID EZH2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID EIF2A GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
    EIF2AK2 BioGRID PRKRA GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID TARBP2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID CHUK GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID SNCA GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID LINC00624 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID vIRF-2 GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID POLY GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID NCK1 GeneID BioGRID Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RAF1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TIPARP GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID K3L GeneID BioGRID Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID E3L GeneID BioGRID Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID HACE1 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID SPIDR GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    EIF2AK2 BioGRID HNRNPUL2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID FTSJ3 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID NIFK GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID LLPH GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPF2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID LAS1L GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID C1orf35 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DDX54 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID KRI1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NOC3L GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DDX24 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PPAN GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NKRF GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DDX27 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID LYAR GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID STRBP GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NAT10 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RBM28 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ZFR GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NOP16 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MRTO4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RRP15 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NOP53 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID GNL2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID STAU2 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID PELP1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NOC2L GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID GTPBP4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RRP8 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID BOP1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RRP1B GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EXOSC7 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PDCD11 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RALY GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DHX30 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Reconstituted Complex
    EIF2AK2 BioGRID EXOSC8 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EBNA1BP2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PRDX3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NSA2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CEBPZ GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID URB1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID URB2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID FXR2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID COG1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PRP4K GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DDX18 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SURF6 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SRPK1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PURA GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EXOSC10 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MOV10 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID ILF3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID DKC1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CDC5L GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ADAR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    EIF2AK2 BioGRID USP53 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID BAP1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TRS1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    EIF2AK2 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID tat GeneID BioGRID Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID STAU1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS
    EIF2AK2 BioGRID SH3PXD2B GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID PTGR2 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID ARFGAP2 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID MCCC2 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID CMPK1 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID SEPHS2 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID HMGN2 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID CARS1 GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID FAS GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID NEIL3 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MYCN GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TRIM31 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EIF2S1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID US11 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID SOX2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PA2G4 GeneID BioGRID Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID DHX9 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID FBXO32 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CKAP4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ZC3H11A GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RHOF GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID IL24 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID MAVS GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    EIF2AK2 BioGRID DUS2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID TOLLIP GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Reconstituted Complex
    EIF2AK2 BioGRID RIGI GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID IRS1 GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID RPL18 GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID CAPRIN1 GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID MAP2K6 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    EIF2AK2 BioGRID PPP2R5A GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    EIF2AK2 BioGRID Adar GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID FBXW7 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID USP32 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CIAO2A GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID UBXN6 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID FNDC8 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MRPL42 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SENP3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EEF1AKMT3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ZC3H3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TRIM35 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CDC37 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NPM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID MECP2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ANOS1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID IFNA14 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID H2AC17 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPS16 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPL35A GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPL19 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PSG11 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PRKY GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CCT8L2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RFXANK GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID H1-4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID GPX7 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID GCH1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CYP1A1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CCNA2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID BTF3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID HNRNPCL2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID FZR1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DDRGK1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID UFL1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ISG15 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID OGT GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID COIL GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID IFI16 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MKRN1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID Apc2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID BRD4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NUPR1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID INS GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CDC42 GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID MRPL58 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID GRSF1 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID CHCHD1 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID MTRFR GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID RPUSD4 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID MTERF3 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID TRUB2 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID FASTKD2 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID XRN2 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    EIF2AK2 BioGRID CIT GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MTRF1 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID TBRG4 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID ZC3H18 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TRADD GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID ESR1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MIR143 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR141 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR140 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR138-2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR138-1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR128-2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR128-1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR122 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR1-2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR1-1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR10B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR107 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR106B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR106A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7I GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7G GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7F2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7F1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7E GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7D GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7C GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7A3 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7A2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIRLET7A1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID NHLRC2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS
    EIF2AK2 BioGRID MIR451A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR18B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR20B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR363 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR429 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR98 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR9-3 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR93 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR92A2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR92A1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR9-2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR9-1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR7-3 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR7-2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR7-1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR34C GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR34B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR34A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR31 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR29C GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR29B2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR29B1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR29A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR25 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR222 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR221 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR214 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR21 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR206 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR205 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR200C GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR200B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR200A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR20A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR19B2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR19B1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR19A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR199A2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR199A1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR18A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR17 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR16-2 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR16-1 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR15B GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR15A GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR155 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID MIR145 GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID OBSL1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ADARB1 GeneID BioGRID Two-hybrid
    EIF2AK2 BioGRID TRIM28 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID BRD7 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SUMO1 GeneID BioGRID Reconstituted Complex
    EIF2AK2 BioGRID UBE2I GeneID BioGRID Biochemical Activity
    EIF2AK2 BioGRID SUMO2 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID BIRC3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SNRNP70 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID Dppa3 GeneID BioGRID Proximity Label-MS
    EIF2AK2 BioGRID HDAC2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NR2C2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SUI2 GeneID BioGRID Biochemical Activity; Phenotypic Suppression; Synthetic Growth Defect
    EIF2AK2 BioGRID TPT1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PHB1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID YGR054W GeneID BioGRID Biochemical Activity
    EIF2AK2 BioGRID RECQL4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID LARP7 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EFTUD2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TRIP4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PCBP1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPS3A GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPS2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPLP0 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPL6 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID LMNA GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DLST GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DLD GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID COX15 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PTEN GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID IQCF1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TP53 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    EIF2AK2 BioGRID THAP12 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID H2AC4 GeneID BioGRID Biochemical Activity
    EIF2AK2 BioGRID MACROD1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MCM2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID Rrbp1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID Kif18b GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CHMP4B GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CDCA5 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MIDEAS GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID RPL10 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SCARB2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID TRAF5 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID EGFR GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID HECW2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID TOP1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DICER1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID IGF2BP2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID IGF2BP3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PABPC4 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ILF2 GeneID BioGRID Affinity Capture-MS; Biochemical Activity
    EIF2AK2 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western
    EIF2AK2 BioGRID GNL3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID NOP2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID HNRNPC GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID H1-2 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-RNA
    EIF2AK2 BioGRID IL7R GeneID BioGRID Protein-RNA
    EIF2AK2 BioGRID gag GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID Jak2 GeneID BioGRID Biochemical Activity
    EIF2AK2 BioGRID TYK2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    EIF2AK2 BioGRID JAK1 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID ATP6V1F GeneID BioGRID Co-fractionation
    EIF2AK2 BioGRID CAND1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID HDGF GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID HNRNPCL1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CCDC124 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID KCTD17 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID DHX58 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID EDC4 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID FARSB GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID SSB GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID PPP1CC GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID EIF6 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    EIF2AK2 BioGRID IFRD1 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID FARSA GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID CDK3 GeneID BioGRID Affinity Capture-MS
    EIF2AK2 BioGRID FANCC GeneID BioGRID Affinity Capture-Western
    EIF2AK2 Protein ELF2 GeneID HPRD None
    EIF2AK2 Protein PPP1CA GeneID HPRD None
    EIF2AK2 Protein PRKRIP1 GeneID HPRD None
    EIF2AK2 Protein STRBP GeneID HPRD None
    EIF2AK2 Protein THAP12 GeneID HPRD None
    EIF2AK2 Protein PPP1CC GeneID HPRD None
    EIF2AK2 Protein PTGES3 GeneID HPRD None
    EIF2AK2 Protein TIRAP GeneID HPRD None
    EIF2AK2 Protein TAB2 GeneID HPRD None
    EIF2AK2 Protein TARBP2 GeneID HPRD None
    EIF2AK2 Protein EIF2S1 GeneID HPRD None
    EIF2AK2 Protein PRKRA GeneID HPRD None
    EIF2AK2 Protein IKBKB GeneID HPRD None
    EIF2AK2 Protein ILF3 GeneID HPRD None
    EIF2AK2 Protein MAP3K7 GeneID HPRD None
    EIF2AK2 Protein MAP3K5 GeneID HPRD None
    EIF2AK2 Protein RAC1 GeneID HPRD None
    EIF2AK2 Protein METAP2 GeneID HPRD None
    EIF2AK2 Protein CASP8 GeneID HPRD None
    EIF2AK2 Protein CASP7 GeneID HPRD None
    EIF2AK2 Protein PPP2R5A GeneID HPRD None
    EIF2AK2 Protein DNAJC3 GeneID HPRD None
    EIF2AK2 Protein CHUK GeneID HPRD None
    EIF2AK2 Protein CASP3 GeneID HPRD None
    EIF2AK2 Protein STAT1 GeneID HPRD None
    EIF2AK2 Protein TP53 GeneID HPRD None
    EIF2AK2 Protein TYK2 GeneID HPRD None
    EIF2AK2 Protein EIF2AK2 GeneID HPRD None
    EIF2AK2 Protein PDGFRB GeneID HPRD None
    EIF2AK2 Protein NPM1 GeneID HPRD None
    EIF2AK2 Protein NFKBIA GeneID HPRD None
    EIF2AK2 Protein JAK1 GeneID HPRD None
    EIF2AK2 Protein HSP90AA1 GeneID HPRD None
    EIF2AK2 Protein HSPA1A GeneID HPRD None
    EIF2AK2 Protein CDC42 GeneID HPRD None
    EIF2AK2 Protein STAT3 GeneID HPRD None
    EIF2AK2 BioGRID PTGES3 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID H2AC20 GeneID BioGRID Biochemical Activity
    EIF2AK2 BioGRID STAT3 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID STAT1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    EIF2AK2 BioGRID DNAJC3 GeneID BioGRID Reconstituted Complex; Two-hybrid
    EIF2AK2 BioGRID PDGFRB GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID MAP3K5 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID IKBKB GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID METAP2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    EIF2AK2 BioGRID PRKRIP1 GeneID BioGRID Affinity Capture-Western
    EIF2AK2 BioGRID DBNL GeneID BioGRID Affinity Capture-MS
    EIF2AK2 Protein EIF2S1 GeneID BIND PKR interacts with eIF2-alpha. This interaction was modeled on a demonstrated interaction between human PKR, and eIF2-alpha from an unspecified species.
    EIF2AK2 Protein PRKRA GeneID BIND PKR interacts with PACT. This interaction was modeled on a demonstrated interaction between human PKR, and PACT from an unspecified species.
    EIF2AK2 Protein HTT GeneID BIND PKR interacts with huntingtin mRNA.
    EIF2AK2 Protein HIV2gp5 GeneID BIND PKR interacts with Tat-2. This interaction was modeled on a demonstrated interaction between PKR from an unspecified species and HIV-2 Tat-2.
    EIF2AK2 Protein tat GeneID BIND PKR phosphorylates Tat. This interaction was modeled on a demonstrated interaction between PKR from an unspecified species and HIV-1 Tat.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    EIF2AK2 RPIA 0 0 0 208 1 1
    EIF2AK2 ATP6V1F 271 0 0 271 1 1
    EIF2AK2 IRAK2 0 0 297 324 1 1
    EIF2AK2 ZNF420 0 0 113 168 1 1
    EIF2AK2 IFIT2 0 0 504 690 1 1
    EIF2AK2 UBE2I 270 0 0 270 1 1
    EIF2AK2 WDR77 0 0 0 160 1 1
    EIF2AK2 FARSB 157 0 0 311 1 1
    EIF2AK2 CCND1 0 0 122 184 1 1
    EIF2AK2 TNFRSF10D 0 0 57 161 1 1
    EIF2AK2 DDB2 0 0 67 175 1 1
    EIF2AK2 COPB1 0 0 81 202 1 1
    EIF2AK2 RCC1 0 0 0 187 1 1
    EIF2AK2 PPIP5K2 0 0 0 187 1 1
    EIF2AK2 PPM1K 0 0 66 158 1 1
    EIF2AK2 RPS9 0 0 0 199 1 1
    EIF2AK2 RFWD2 0 0 127 167 1 1
    EIF2AK2 RPS6KB1 0 0 156 152 1 2
    EIF2AK2 PPP2CA 0 0 74 189 1 1
    EIF2AK2 DHX30 619 0 111 682 1 1
    EIF2AK2 SRP68 0 0 0 199 1 1
    EIF2AK2 DAGLB 0 0 0 168 1 1
    EIF2AK2 EIF4E 0 0 195 384 1 1
    EIF2AK2 NCOR1 0 0 0 189 1 1
    EIF2AK2 CDK1 270 0 95 310 1 1
    EIF2AK2 LIPA 0 0 0 157 1 1
    EIF2AK2 GNLY 0 0 66 278 1 1
    EIF2AK2 FAM46A 0 0 212 217 1 1
    EIF2AK2 SPNS3 0 0 0 183 1 1
    EIF2AK2 DDX60 0 0 370 583 1 1
    EIF2AK2 IRS1 0 800 169 942 1 1
    EIF2AK2 STAU2 561 0 138 676 1 1
    EIF2AK2 TXN 0 0 112 174 1 1
    EIF2AK2 CANX 0 0 134 335 1 2
    EIF2AK2 LST1 0 0 180 179 1 1
    EIF2AK2 SNRPA1 0 0 0 224 1 1
    EIF2AK2 DEFB134 0 0 0 210 1 1
    EIF2AK2 DEK 0 0 0 228 1 1
    EIF2AK2 ERCC6L2 0 0 0 212 1 1
    EIF2AK2 BARD1 0 0 43 160 1 1
    EIF2AK2 HELZ2 0 0 285 580 1 1
    EIF2AK2 HELZ 0 0 0 176 1 1
    EIF2AK2 TRPS1 0 0 0 153 1 1
    EIF2AK2 CAPRIN1 0 0 62 549 1 1
    EIF2AK2 GNB2L1 0 0 90 523 1 1
    EIF2AK2 ETV2 0 0 0 203 1 1
    EIF2AK2 DNAJB2 0 0 95 157 1 1
    EIF2AK2 DDX46 0 0 66 273 1 1
    EIF2AK2 RNASEL 0 0 566 680 1 1
    EIF2AK2 HPRT1 0 0 150 169 1 1
    EIF2AK2 IFRD1 157 0 95 214 1 1
    EIF2AK2 ATF7 0 0 0 168 1 1
    EIF2AK2 PRSS35 0 0 97 172 1 1
    EIF2AK2 IFI44 0 0 560 834 1 1
    EIF2AK2 PRKRIR 462 0 539 747 1 1
    EIF2AK2 TMEM189-UBE2V1 0 0 150 227 1 1
    EIF2AK2 PTPN2 0 900 70 911 1 2
    EIF2AK2 IFI27 0 0 464 470 1 1
    EIF2AK2 GPATCH11 0 0 211 211 1 1
    EIF2AK2 HERC6 0 0 324 574 1 1
    EIF2AK2 BTF3 0 0 0 310 1 1
    EIF2AK2 NAA35 0 0 0 169 1 1
    EIF2AK2 DAGLA 0 0 0 168 1 1
    EIF2AK2 OBSL1 270 0 0 297 1 1
    EIF2AK2 STIP1 0 0 0 184 1 1
    EIF2AK2 RAVER1 0 0 0 155 1 1
    EIF2AK2 DDX3X 0 0 193 397 1 1
    EIF2AK2 EEF2 0 0 96 276 1 1
    EIF2AK2 IQCF1 179 0 0 179 1 1
    EIF2AK2 RBM8A 0 0 279 279 1 1
    EIF2AK2 PPP1R15A 0 0 384 734 1 2
    EIF2AK2 RBBP7 0 0 0 158 1 1
    EIF2AK2 RPLP0 270 0 46 461 1 1
    EIF2AK2 NBR1 0 0 81 196 1 2
    EIF2AK2 CELF1 0 0 305 310 1 1
    EIF2AK2 YBX1 0 0 45 272 1 1
    EIF2AK2 IFITM1 0 0 375 414 1 1
    EIF2AK2 TNF 0 0 302 408 1 1
    EIF2AK2 TIRAP 213 900 124 941 1 1
    EIF2AK2 SIN3A 0 0 55 179 1 1
    EIF2AK2 VAPB 0 0 95 171 1 1
    EIF2AK2 IL1RN 0 0 241 257 1 1
    EIF2AK2 TDRD7 0 0 112 205 1 1
    EIF2AK2 PIK3R2 0 0 167 170 1 1
    EIF2AK2 IFI35 0 0 456 623 1 1
    EIF2AK2 IFNL1 0 0 323 323 1 1
    EIF2AK2 RPS10 0 0 0 505 1 1
    EIF2AK2 N4BP2 0 0 107 281 1 1
    EIF2AK2 GSTM5 0 0 279 279 1 1
    EIF2AK2 C19orf66 0 0 219 310 1 1
    EIF2AK2 CCDC107 0 0 195 195 1 1
    EIF2AK2 G3BP1 0 0 244 403 1 1
    EIF2AK2 ATF3 0 0 232 375 1 1
    EIF2AK2 IFNW1 0 0 167 167 1 1
    EIF2AK2 GBP5 0 0 57 201 1 1
    EIF2AK2 GLTSCR2 157 0 0 184 1 1
    EIF2AK2 UVRAG 0 0 431 457 1 2
    EIF2AK2 IRF7 0 0 557 694 1 1
    EIF2AK2 RNF41 0 0 0 372 1 1
    EIF2AK2 SOCS1 0 0 253 269 1 1
    EIF2AK2 TAF5 0 0 0 161 1 1
    EIF2AK2 SUPT6H 0 0 0 154 1 1
    EIF2AK2 CUL4B 0 0 0 160 1 1
    EIF2AK2 IFNAR1 0 0 464 495 1 1
    EIF2AK2 AZIN1 0 0 123 206 1 1
    EIF2AK2 TNFAIP3 0 0 203 256 1 1
    EIF2AK2 POTEI 0 0 0 150 1 1
    EIF2AK2 EDEM1 0 0 194 413 1 2
    EIF2AK2 GSTP1 0 0 357 357 1 1
    EIF2AK2 NFKB2 0 0 162 212 1 1
    EIF2AK2 PARP15 0 0 0 163 1 1
    EIF2AK2 ATG4B 0 0 81 238 1 2
    EIF2AK2 RPL7A 0 0 0 307 1 1
    EIF2AK2 IFNL2 0 0 260 260 1 1
    EIF2AK2 PLEKHA4 270 0 0 270 1 1
    EIF2AK2 IFI16 270 0 340 563 1 1
    EIF2AK2 YME1L1 0 0 118 216 1 1
    EIF2AK2 PYCARD 0 0 107 262 1 1
    EIF2AK2 PRKRA 870 900 637 994 1 1
    EIF2AK2 AHSA1 0 0 47 189 1 1
    EIF2AK2 TLR9 0 0 263 305 1 1
    EIF2AK2 TRIM2 0 0 122 160 1 1
    EIF2AK2 ILF2 270 0 520 666 1 1
    EIF2AK2 IRF3 0 0 452 462 1 1
    EIF2AK2 UBA7 0 0 125 271 1 1
    EIF2AK2 PSMC1 0 0 123 372 1 1
    EIF2AK2 DHODH 0 0 0 159 1 1
    EIF2AK2 FUBP1 0 0 0 179 1 1
    EIF2AK2 TAP1 0 0 108 152 1 1
    EIF2AK2 RNF213 0 0 66 581 1 1
    EIF2AK2 MTG2 0 0 0 208 1 1
    EIF2AK2 INO80 0 0 0 150 1 1
    EIF2AK2 PINK1 0 0 71 200 1 2
    EIF2AK2 IFNGR2 0 0 134 168 1 1
    EIF2AK2 RPL29 0 0 0 288 1 1
    EIF2AK2 IL24 0 0 134 217 1 2
    EIF2AK2 NT5C3A 0 0 155 184 1 1
    EIF2AK2 HSP90AB1 129 0 52 308 1 2
    EIF2AK2 PABPC4 157 0 0 211 1 1
    EIF2AK2 DHX16 0 0 0 203 1 1
    EIF2AK2 ADRM1 0 0 45 268 1 1
    EIF2AK2 CXCL10 0 0 361 403 1 1
    EIF2AK2 MACROD2 0 0 0 163 1 1
    EIF2AK2 USP25 0 0 0 167 1 1
    EIF2AK2 EIF4EBP1 0 0 151 282 1 1
    EIF2AK2 PIKFYVE 0 0 0 167 1 1
    EIF2AK2 ENSG00000144785 0 0 0 267 1 1
    EIF2AK2 WDR78 0 0 0 161 1 1
    EIF2AK2 RPLP2 0 0 69 171 1 1
    EIF2AK2 CREB3L4 0 0 108 163 1 1
    EIF2AK2 TPT1 270 0 0 435 1 1
    EIF2AK2 ATF6 0 0 504 765 1 2
    EIF2AK2 IKBKB 270 600 113 718 1 1
    EIF2AK2 GSTM1 0 0 296 296 1 1
    EIF2AK2 NLRC4 270 0 143 361 1 2
    EIF2AK2 PSME4 0 0 0 175 1 1
    EIF2AK2 DROSHA 0 0 134 188 1 1
    EIF2AK2 ABCF3 0 0 0 495 1 1
    EIF2AK2 THAP5 0 0 143 275 1 1
    EIF2AK2 KMT2D 0 0 0 172 1 1
    EIF2AK2 RPL35 0 0 0 428 1 1
    EIF2AK2 THOC6 0 0 0 190 1 1
    EIF2AK2 PPP1R13L 0 0 109 357 1 1
    EIF2AK2 SETX 0 0 0 183 1 1
    EIF2AK2 AKT1 0 0 246 214 1 2
    EIF2AK2 GBP2 0 0 328 365 1 1
    EIF2AK2 CLPP 0 0 74 166 1 1
    EIF2AK2 CSF2 0 0 150 199 1 1
    EIF2AK2 PARP4 0 0 71 166 1 1
    EIF2AK2 LY96 0 900 142 912 1 1
    EIF2AK2 SUMO1 270 0 71 431 1 1
    EIF2AK2 IFIT3 0 0 519 866 1 1
    EIF2AK2 GARS 0 0 90 159 1 1
    EIF2AK2 MBTPS1 0 0 108 279 1 1
    EIF2AK2 CD4 0 0 234 274 1 1
    EIF2AK2 HSPH1 0 0 0 260 1 1
    EIF2AK2 ATF4 0 0 390 606 1 2
    EIF2AK2 RPL26 0 0 45 418 1 1
    EIF2AK2 PIGO 0 0 75 272 1 1
    EIF2AK2 NOC3L 157 0 0 156 1 1
    EIF2AK2 C1QB 0 0 193 204 1 1
    EIF2AK2 TAF5L 0 0 0 161 1 1
    EIF2AK2 ZBTB41 0 0 136 285 1 1
    EIF2AK2 DIS3 0 0 0 287 1 1
    EIF2AK2 HACE1 0 0 0 158 1 1
    EIF2AK2 DDB1 0 0 64 436 1 1
    EIF2AK2 TSC2 0 0 123 203 1 2
    EIF2AK2 PRPF3 0 0 0 173 1 1
    EIF2AK2 IFIT1 0 800 601 971 1 1
    EIF2AK2 GSTZ1 0 0 498 497 1 1
    EIF2AK2 PGP 0 0 97 160 1 1
    EIF2AK2 EIF4H 0 0 55 161 1 1
    EIF2AK2 USP7 0 0 0 167 1 1
    EIF2AK2 ZGRF1 0 0 0 159 1 1
    EIF2AK2 MOV10L1 0 0 0 197 1 1
    EIF2AK2 RPL26L1 0 0 95 178 1 1
    EIF2AK2 ZNF488 0 0 107 201 1 1
    EIF2AK2 PPWD1 0 0 120 295 1 1
    EIF2AK2 TBK1 0 0 194 203 1 2
    EIF2AK2 TICAM2 0 0 134 157 1 1
    EIF2AK2 C11orf73 0 0 123 215 1 1
    EIF2AK2 ATF6B 0 0 45 315 1 1
    EIF2AK2 PLRG1 0 0 0 222 1 1
    EIF2AK2 RPL11 0 0 47 293 1 1
    EIF2AK2 PACSIN1 0 0 327 327 1 1
    EIF2AK2 RRP1B 270 0 0 279 1 1
    EIF2AK2 JAK1 270 300 243 536 1 1
    EIF2AK2 EIF2S1 870 900 606 997 1 2
    EIF2AK2 PRMT5 0 0 0 153 1 1
    EIF2AK2 HARS2 0 0 103 256 1 1
    EIF2AK2 DNAJB1 0 0 115 219 1 2
    EIF2AK2 ATG3 0 0 113 268 1 2
    EIF2AK2 TLR3 0 0 460 574 1 1
    EIF2AK2 TRIM28 270 0 90 347 1 2
    EIF2AK2 PLSCR1 0 0 454 531 1 1
    EIF2AK2 JDP2 0 0 0 168 1 1
    EIF2AK2 PARP9 0 0 341 487 1 1
    EIF2AK2 RSAD2 0 0 566 876 1 1
    EIF2AK2 UTP14A 0 0 0 168 1 1
    EIF2AK2 CD180 0 0 95 200 1 1
    EIF2AK2 PSMB5 0 0 105 152 1 1
    EIF2AK2 DBNL 244 0 57 256 1 1
    EIF2AK2 TEN1-CDK3 157 0 107 222 1 1
    EIF2AK2 STK25 0 0 112 170 1 1
    EIF2AK2 EIF2AK3 0 0 556 254 1 2
    EIF2AK2 KLHL13 0 0 95 153 1 1
    EIF2AK2 IGHMBP2 0 0 0 167 1 1
    EIF2AK2 SHISA5 0 0 90 185 1 1
    EIF2AK2 CREB5 0 0 0 168 1 1
    EIF2AK2 CRY1 0 0 0 398 1 1
    EIF2AK2 KDM6A 0 0 0 173 1 1
    EIF2AK2 PLB1 0 0 66 210 1 1
    EIF2AK2 ARMC3 0 0 0 207 1 1
    EIF2AK2 GATA5 0 0 0 153 1 1
    EIF2AK2 CNPY1 0 0 0 245 1 1
    EIF2AK2 GFM1 0 0 0 206 1 1
    EIF2AK2 SAMD9L 0 0 247 457 1 1
    EIF2AK2 IRF8 0 0 193 193 1 1
    EIF2AK2 TTC12 0 0 0 158 1 1
    EIF2AK2 ADA 0 0 324 328 1 1
    EIF2AK2 MCM3 0 0 46 155 1 1
    EIF2AK2 IRS4 0 800 0 816 1 1
    EIF2AK2 EIF6 397 0 105 459 1 1
    EIF2AK2 SIN3B 0 0 0 188 1 1
    EIF2AK2 RPS8 0 0 0 271 1 1
    EIF2AK2 CDC42 270 0 123 347 1 1
    EIF2AK2 CD99L2 0 0 91 332 1 1
    EIF2AK2 CHUK 678 600 159 878 1 1
    EIF2AK2 SAMHD1 0 0 232 249 1 1
    EIF2AK2 RPS15 0 0 0 320 1 1
    EIF2AK2 RPS4X 0 0 87 351 1 1
    EIF2AK2 EPSTI1 0 0 261 314 1 1
    EIF2AK2 CASP4 0 0 136 246 1 2
    EIF2AK2 ALX3 0 0 59 192 1 1
    EIF2AK2 HDAC1 0 0 54 152 1 2
    EIF2AK2 COPS4 0 0 0 182 1 1
    EIF2AK2 PTGES3 270 0 0 298 1 1
    EIF2AK2 RIPK1 0 800 157 822 1 1
    EIF2AK2 DTX3L 0 0 188 327 1 1
    EIF2AK2 ZNF431 0 0 213 213 1 1
    EIF2AK2 ERO1LB 0 0 84 205 1 1
    EIF2AK2 IFIT1B 0 800 92 845 1 1
    EIF2AK2 UBE2L6 0 900 261 931 1 1
    EIF2AK2 CEBPB 0 0 163 220 1 1
    EIF2AK2 ATG16L1 0 0 103 192 1 2
    EIF2AK2 CDC42EP1 0 0 113 189 1 1
    EIF2AK2 ENSG00000258838 0 0 0 212 1 1
    EIF2AK2 KIDINS220 0 0 0 254 1 1
    EIF2AK2 PI4KA 0 0 67 190 1 1
    EIF2AK2 PDIA4 0 0 0 177 1 1
    EIF2AK2 CIITA 0 0 74 248 1 1
    EIF2AK2 CHD8 0 0 0 153 1 1
    EIF2AK2 EEF1A1 0 0 113 179 1 1
    EIF2AK2 PTGS2 0 0 125 157 1 1
    EIF2AK2 PSMB9 0 0 250 266 1 1
    EIF2AK2 DDX6 0 0 107 211 1 1
    EIF2AK2 CLEC4M 0 0 122 188 1 1
    EIF2AK2 RPSA 0 0 0 183 1 1
    EIF2AK2 ZSCAN26 0 0 123 163 1 1
    EIF2AK2 CASP3 213 0 206 489 1 2
    EIF2AK2 EIF4B 0 0 72 291 1 1
    EIF2AK2 DHX29 0 0 0 161 1 1
    EIF2AK2 DAXX 0 0 117 156 1 1
    EIF2AK2 CDC27 0 0 0 191 1 1
    EIF2AK2 HSPA1B 0 0 0 167 1 1
    EIF2AK2 NLRP3 270 0 210 571 1 2
    EIF2AK2 LNX1 0 0 0 385 1 1
    EIF2AK2 REL 0 0 107 151 1 1
    EIF2AK2 PSMB6 0 0 103 150 1 1
    EIF2AK2 CXCL1 0 0 125 165 1 1
    EIF2AK2 HAAO 0 0 352 351 1 1
    EIF2AK2 PSMG1 0 0 0 183 1 1
    EIF2AK2 TRIB3 0 0 230 293 1 1
    EIF2AK2 CPSF4 0 0 234 252 1 1
    EIF2AK2 NR2C2 270 0 120 342 1 1
    EIF2AK2 HELLS 0 0 0 153 1 1
    EIF2AK2 SMARCA1 0 0 0 153 1 1
    EIF2AK2 RNF151 0 0 0 372 1 1
    EIF2AK2 IFNA5 0 0 232 231 1 1
    EIF2AK2 HARS 0 0 113 270 1 1
    EIF2AK2 PSMC4 0 0 0 288 1 1
    EIF2AK2 TRIM22 0 0 395 452 1 1
    EIF2AK2 TRIM56 0 0 66 208 1 1
    EIF2AK2 DTX3 0 0 0 250 1 1
    EIF2AK2 USP48 0 0 0 167 1 1
    EIF2AK2 CYBB 0 0 128 200 1 1
    EIF2AK2 PHF21B 0 0 0 162 1 1
    EIF2AK2 ATG12 0 0 134 267 1 2
    EIF2AK2 TNFRSF10B 0 0 112 210 1 1
    EIF2AK2 RPL31 0 0 0 347 1 1
    EIF2AK2 TNFSF13B 0 0 202 236 1 1
    EIF2AK2 MACROD1 270 0 0 363 1 1
    EIF2AK2 SSB 157 0 113 278 1 1
    EIF2AK2 TRAF3 0 0 140 436 1 2
    EIF2AK2 WARS 0 0 260 273 1 1
    EIF2AK2 PHB 270 0 0 270 1 1
    EIF2AK2 LRRK2 270 0 67 337 1 2
    EIF2AK2 TOLLIP 157 900 116 927 1 1
    EIF2AK2 PIAS1 0 0 145 186 1 1
    EIF2AK2 IFITM5 0 0 143 176 1 1
    EIF2AK2 ZDHHC11 0 0 0 217 1 1
    EIF2AK2 RPL23A 0 0 0 504 1 1
    EIF2AK2 PMAIP1 0 0 103 166 1 1
    EIF2AK2 TLR2 0 0 234 301 1 1
    EIF2AK2 DUSP1 0 0 122 160 1 1
    EIF2AK2 IFT57 0 0 308 307 1 1
    EIF2AK2 TLR6 0 0 150 218 1 1
    EIF2AK2 IL2 0 0 166 165 1 1
    EIF2AK2 ZC3HAV1 0 0 193 306 1 1
    EIF2AK2 SAAL1 0 0 156 214 1 1
    EIF2AK2 SDC1 0 0 49 151 1 1
    EIF2AK2 MAPT 270 0 62 285 1 2
    EIF2AK2 BECN1 0 0 490 555 1 2
    EIF2AK2 EEF1D 0 0 0 384 1 1
    EIF2AK2 PDIA3 0 0 74 190 1 1
    EIF2AK2 GRID2 0 0 410 410 1 2
    EIF2AK2 IFNA17 0 0 253 253 1 1
    EIF2AK2 DNAJB9 0 0 224 363 1 2
    EIF2AK2 CLDN9 0 0 123 177 1 1
    EIF2AK2 IFNA13 0 0 206 206 1 1
    EIF2AK2 SEC62 0 0 97 189 1 1
    EIF2AK2 ALPK2 0 0 205 236 1 1
    EIF2AK2 CD86 0 0 125 159 1 1
    EIF2AK2 EIF2S3 0 900 249 928 1 1
    EIF2AK2 GSTM2 0 0 435 435 1 1
    EIF2AK2 RPS11 0 0 0 503 1 1
    EIF2AK2 XAF1 0 0 349 701 1 1
    EIF2AK2 ZNF665 0 0 150 184 1 1
    EIF2AK2 IFNL3 0 0 321 321 1 1
    EIF2AK2 GTF2F2 0 0 0 183 1 1
    EIF2AK2 MCM6 0 0 103 202 1 1
    EIF2AK2 S100A13 0 0 0 170 1 1
    EIF2AK2 PSME2 0 0 267 294 1 1
    EIF2AK2 MNDA 0 0 113 186 1 1
    EIF2AK2 MBNL2 0 0 501 501 1 1
    EIF2AK2 FGL1 0 0 68 269 1 1
    EIF2AK2 SOCS3 0 0 235 278 1 1
    EIF2AK2 EIF3B 0 0 150 306 1 1
    EIF2AK2 KDM6B 0 0 0 173 1 1
    EIF2AK2 FOS 0 0 151 263 1 1
    EIF2AK2 RPL10 129 0 0 398 1 1
    EIF2AK2 CCT7 0 0 0 181 1 1
    EIF2AK2 NELFB 0 0 0 153 1 1
    EIF2AK2 IFNGR1 0 0 288 288 1 1
    EIF2AK2 HLA-B 0 0 158 157 1 1
    EIF2AK2 EBNA1BP2 157 0 0 184 1 1
    EIF2AK2 FOXO1 0 0 112 167 1 2
    EIF2AK2 RPS14 0 0 0 486 1 1
    EIF2AK2 KRAS 0 0 66 170 1 1
    EIF2AK2 RPS15A 0 0 74 482 1 1
    EIF2AK2 SYNCRIP 0 0 82 163 1 1
    EIF2AK2 DRG1 0 0 0 179 1 1
    EIF2AK2 DCP1A 0 0 60 184 1 1
    EIF2AK2 HNRNPC 157 0 85 242 1 1
    EIF2AK2 RPS21 0 0 0 303 1 1
    EIF2AK2 EIF4A2 0 0 210 270 1 1
    EIF2AK2 ZNF346 157 0 0 156 1 1
    EIF2AK2 HSPA5 0 0 508 814 1 2
    EIF2AK2 SLC35B2 0 0 0 152 1 1
    EIF2AK2 UPF1 0 0 67 230 1 1
    EIF2AK2 EIF4G2 0 0 95 266 1 1
    EIF2AK2 RPS23 0 0 0 303 1 1
    EIF2AK2 SETD2 0 0 305 323 1 1
    EIF2AK2 UBE3B 0 0 112 222 1 1
    EIF2AK2 TM4SF1 0 0 0 210 1 1
    EIF2AK2 ZC3H18 270 0 0 298 1 1
    EIF2AK2 RPS18 0 0 0 506 1 1
    EIF2AK2 SKIL 0 0 0 256 1 1
    EIF2AK2 PACSIN2 0 0 306 306 1 1
    EIF2AK2 RPL18A 0 0 107 375 1 1
    EIF2AK2 RPL5 0 0 0 504 1 1
    EIF2AK2 PRKCA 0 0 112 161 1 1
    EIF2AK2 FANCL 0 0 0 177 1 1
    EIF2AK2 C1QC 0 0 92 154 1 1
    EIF2AK2 MT-CYB 0 0 0 392 1 1
    EIF2AK2 TIAL1 0 0 107 271 1 1
    EIF2AK2 PCBP1 108 0 0 162 1 1
    EIF2AK2 PDCD2L 0 0 0 173 1 1
    EIF2AK2 IKBKG 0 600 141 642 1 1
    EIF2AK2 MAP4K4 0 900 166 905 1 1
    EIF2AK2 RARS 0 0 0 197 1 1
    EIF2AK2 QARS 0 0 55 225 1 1
    EIF2AK2 USP18 0 900 459 967 1 1
    EIF2AK2 PACSIN3 0 0 328 328 1 1
    EIF2AK2 ATG10 0 0 107 160 1 2
    EIF2AK2 GBP3 0 0 236 278 1 1
    EIF2AK2 RANBP1 0 0 0 288 1 1
    EIF2AK2 PMPCB 0 0 72 162 1 1
    EIF2AK2 UBAP2L 0 0 0 228 1 1
    EIF2AK2 SUGT1 0 0 0 158 1 1
    EIF2AK2 EIF2A 487 900 269 970 1 1
    EIF2AK2 ISG15 0 600 602 931 1 1
    EIF2AK2 LY6E 0 0 390 427 1 1
    EIF2AK2 MAP1LC3B 0 0 87 210 1 2
    EIF2AK2 CHD3 0 0 0 162 1 1
    EIF2AK2 TIA1 0 0 171 330 1 1
    EIF2AK2 CTPS1 0 0 0 212 1 1
    EIF2AK2 TLR8 0 0 258 285 1 1
    EIF2AK2 SH2D3A 0 0 107 162 1 1
    EIF2AK2 ERCC6 0 0 0 212 1 1
    EIF2AK2 ILKAP 0 0 0 154 1 1
    EIF2AK2 ATG5 0 0 184 325 1 2
    EIF2AK2 NLRP14 0 0 0 202 1 1
    EIF2AK2 SAMD9 0 0 195 335 1 1
    EIF2AK2 PUM1 0 0 44 210 1 1
    EIF2AK2 MIB1 0 0 0 175 1 1
    EIF2AK2 TNFAIP2 0 0 90 171 1 1
    EIF2AK2 GATA6 0 0 0 153 1 1
    EIF2AK2 IRF1 0 0 469 534 1 1
    EIF2AK2 STAT2 0 0 517 603 1 1
    EIF2AK2 RPL27A 0 0 66 250 1 1
    EIF2AK2 GIT1 0 0 321 321 1 1
    EIF2AK2 RCN1 0 0 73 173 1 1
    EIF2AK2 XBP1 0 0 455 742 1 2
    EIF2AK2 RPL23 0 0 0 502 1 1
    EIF2AK2 MBNL1 0 0 327 350 1 1
    EIF2AK2 PDZRN3 0 0 0 372 1 1
    EIF2AK2 AIRE 0 0 0 162 1 1
    EIF2AK2 IL10RB 0 0 184 183 1 1
    EIF2AK2 MCL1 0 0 125 216 1 2
    EIF2AK2 MAPK8IP3 0 0 147 277 1 1
    EIF2AK2 SERBP1 0 0 0 219 1 1
    EIF2AK2 ZNF432 0 0 164 163 1 1
    EIF2AK2 IFNB1 0 0 556 589 1 1
    EIF2AK2 PPP1CA 270 0 134 410 1 1
    EIF2AK2 IRF5 0 0 232 284 1 1
    EIF2AK2 RAC1 213 0 0 231 1 1
    EIF2AK2 HMGB1 0 0 113 189 1 2
    EIF2AK2 MAP3K5 270 0 167 374 1 1
    EIF2AK2 LENG8 0 0 124 150 1 1
    EIF2AK2 PSMC5 0 0 0 289 1 1
    EIF2AK2 BACE1 0 0 97 220 1 1
    EIF2AK2 H2AFY 0 0 0 163 1 1
    EIF2AK2 GATA2 0 0 0 153 1 1
    EIF2AK2 NFE2L1 0 0 60 158 1 1
    EIF2AK2 RPL34 0 0 0 271 1 1
    EIF2AK2 NFKBIA 213 0 218 412 1 1
    EIF2AK2 PHF6 0 0 0 203 1 1
    EIF2AK2 PPP1R9A 0 0 0 301 1 1
    EIF2AK2 MARK2 0 0 82 167 1 1
    EIF2AK2 RPS24 0 0 84 557 1 1
    EIF2AK2 SREBF1 0 0 74 163 1 2
    EIF2AK2 ERCC6L 0 0 0 230 1 1
    EIF2AK2 DNAJC1 0 0 150 201 1 1
    EIF2AK2 RABGGTA 0 0 0 248 1 1
    EIF2AK2 RPL10A 0 0 60 533 1 1
    EIF2AK2 PTEN 270 0 108 362 1 2
    EIF2AK2 NCOA6 0 0 112 354 1 1
    EIF2AK2 RPS29 0 0 0 426 1 1
    EIF2AK2 HECW2 270 0 0 288 1 1
    EIF2AK2 YARS 0 0 0 302 1 1
    EIF2AK2 IFNA21 0 0 294 294 1 1
    EIF2AK2 BST2 0 0 291 379 1 1
    EIF2AK2 TXN2 0 0 113 162 1 1
    EIF2AK2 TRAFD1 0 0 204 271 1 1
    EIF2AK2 RPS20 0 0 0 169 1 1
    EIF2AK2 DET1 0 0 0 167 1 1
    EIF2AK2 KIAA0226 0 0 433 446 1 1
    EIF2AK2 CYTIP 0 0 0 215 1 1
    EIF2AK2 CASP5 0 0 57 177 1 1
    EIF2AK2 TRAF7 0 0 0 381 1 1
    EIF2AK2 FTSJ3 157 0 0 156 1 1
    EIF2AK2 EIF3C 0 0 75 209 1 1
    EIF2AK2 CMPK2 0 0 166 325 1 1
    EIF2AK2 SP110 0 0 430 607 1 1
    EIF2AK2 CNPY2 0 0 0 267 1 1
    EIF2AK2 FOSL2 0 0 0 168 1 1
    EIF2AK2 RPL21 0 0 72 594 1 1
    EIF2AK2 ACTG1 0 0 134 200 1 1
    EIF2AK2 RECQL4 270 0 0 287 1 1
    EIF2AK2 RPL38 0 0 0 302 1 1
    EIF2AK2 USP34 0 0 0 163 1 1
    EIF2AK2 DHX8 0 0 0 196 1 1
    EIF2AK2 TRAT1 0 0 175 175 1 1
    EIF2AK2 PPP1R15B 0 0 103 414 1 1
    EIF2AK2 IFNA8 0 0 150 228 1 1
    EIF2AK2 CCAR1 0 0 69 189 1 1
    EIF2AK2 ATG7 0 0 307 336 1 2
    EIF2AK2 FOSB 0 0 57 181 1 1
    EIF2AK2 NPM1 486 0 54 553 1 1
    EIF2AK2 GRWD1 0 0 0 152 1 1
    EIF2AK2 RPS3A 270 0 72 515 1 1
    EIF2AK2 SEMA6B 0 0 0 245 1 1
    EIF2AK2 ABCE1 0 0 66 186 1 1
    EIF2AK2 CHD4 0 0 0 203 1 1
    EIF2AK2 PA2G4 0 0 81 187 1 1
    EIF2AK2 IL10 0 0 226 245 1 1
    EIF2AK2 PIEZO1 0 0 90 331 1 1
    EIF2AK2 PSMB10 0 0 113 154 1 1
    EIF2AK2 HIST1H1C 157 0 0 174 1 1
    EIF2AK2 PWP1 0 0 0 186 1 1
    EIF2AK2 FRYL 0 0 87 222 1 1
    EIF2AK2 ADARB1 658 0 95 699 1 1
    EIF2AK2 EIF3F 0 0 122 187 1 1
    EIF2AK2 CCL3 0 0 152 151 1 1
    EIF2AK2 TTC28 0 0 0 158 1 1
    EIF2AK2 OGT 0 0 0 170 1 1
    EIF2AK2 RAD23B 0 0 0 165 1 1
    EIF2AK2 EIF3D 0 0 166 332 1 1
    EIF2AK2 LYAR 157 0 0 175 1 1
    EIF2AK2 RPS13 0 0 0 424 1 1
    EIF2AK2 NFKBIZ 0 0 91 167 1 1
    EIF2AK2 ZBP1 0 0 125 278 1 1
    EIF2AK2 PABPC1 0 0 180 434 1 1
    EIF2AK2 MAP3K7 270 0 233 354 1 1
    EIF2AK2 DDIT3 0 0 405 702 1 2
    EIF2AK2 TRAF1 0 0 124 426 1 1
    EIF2AK2 RPL28 0 0 0 271 1 1
    EIF2AK2 GNL3 157 0 0 164 1 1
    EIF2AK2 LMNA 270 0 90 319 1 1
    EIF2AK2 RPL36 0 0 0 325 1 1
    EIF2AK2 ARPC2 0 0 72 319 1 1
    EIF2AK2 IRAK1 0 900 155 909 1 1
    EIF2AK2 RPS16 0 0 0 181 1 1
    EIF2AK2 NCOR2 0 0 0 189 1 1
    EIF2AK2 HTT 0 0 293 308 1 1
    EIF2AK2 PPP1CC 415 0 115 600 1 1
    EIF2AK2 MYD88 0 900 321 934 1 1
    EIF2AK2 METAP2 270 0 0 283 1 1
    EIF2AK2 EGFR 117 0 123 150 1 1
    EIF2AK2 CFLAR 0 0 123 237 1 1
    EIF2AK2 NCKAP1 0 0 122 211 1 1
    EIF2AK2 RPS28 0 0 0 352 1 1
    EIF2AK2 ANKFY1 0 0 76 166 1 1
    EIF2AK2 STAU1 458 0 157 573 1 1
    EIF2AK2 SARM1 0 0 149 225 1 1
    EIF2AK2 FADD 0 800 231 864 1 2
    EIF2AK2 CREBZF 0 0 73 216 1 1
    EIF2AK2 GART 0 0 0 288 1 1
    EIF2AK2 IRF9 0 0 504 600 1 1
    EIF2AK2 TP53 678 900 260 977 1 2
    EIF2AK2 IFNA2 0 0 391 390 1 1
    EIF2AK2 FANCC 486 0 428 861 1 1
    EIF2AK2 STAT3 270 900 497 982 1 2
    EIF2AK2 SUCLG1 0 0 54 303 1 1
    EIF2AK2 TBRG1 0 0 0 172 1 1
    EIF2AK2 EIF2AK4 0 0 595 329 1 1
    EIF2AK2 UACA 0 0 122 169 1 1
    EIF2AK2 GATA3 0 0 0 153 1 1
    EIF2AK2 SPTLC1 0 0 0 157 1 1
    EIF2AK2 ERN1 0 0 517 336 1 2
    EIF2AK2 NR4A1 0 0 124 274 1 1
    EIF2AK2 RPGR 0 0 0 269 1 1
    EIF2AK2 FRY 0 0 0 156 1 1
    EIF2AK2 TRIM6-TRIM34 0 0 96 180 1 1
    EIF2AK2 RBM3 0 0 330 358 1 1
    EIF2AK2 PSME3 0 0 89 167 1 1
    EIF2AK2 G3BP2 0 0 67 289 1 1
    EIF2AK2 NLRC5 0 0 150 181 1 1
    EIF2AK2 BRD7 270 0 0 297 1 1
    EIF2AK2 ZNF335 0 0 91 257 1 1
    EIF2AK2 RPL15 0 0 47 293 1 1
    EIF2AK2 IL2RA 0 0 96 220 1 1
    EIF2AK2 USP10 0 0 0 249 1 2
    EIF2AK2 GAB2 0 0 0 188 1 1
    EIF2AK2 TOP1 157 0 66 227 1 1
    EIF2AK2 UBL5 0 0 125 214 1 1
    EIF2AK2 TRAF2 486 0 134 745 1 1
    EIF2AK2 RPL27 0 0 82 308 1 1
    EIF2AK2 TAB1 0 0 65 266 1 1
    EIF2AK2 EDC4 157 0 57 208 1 1
    EIF2AK2 P4HB 0 0 135 386 1 2
    EIF2AK2 YTHDF2 0 0 0 272 1 1
    EIF2AK2 GPX7 179 0 0 179 1 1
    EIF2AK2 MX1 0 500 663 947 1 1
    EIF2AK2 EFTUD2 240 0 0 284 1 1
    EIF2AK2 LARP7 270 0 0 304 1 1
    EIF2AK2 TAB2 213 0 108 277 1 1
    EIF2AK2 SCARB2 211 0 0 221 1 1
    EIF2AK2 PARP12 0 0 261 438 1 1
    EIF2AK2 PPIP5K1 0 0 0 187 1 1
    EIF2AK2 PARK2 0 0 56 175 1 1
    EIF2AK2 IFNA1 0 0 519 519 1 1
    EIF2AK2 IL18 0 0 211 233 1 1
    EIF2AK2 PURA 157 0 67 179 1 1
    EIF2AK2 RPL35A 0 0 0 159 1 1
    EIF2AK2 RPS26 0 0 0 302 1 1
    EIF2AK2 HNRNPCL1 157 0 0 175 1 1
    EIF2AK2 IFITM3 0 0 390 440 1 1
    EIF2AK2 IL15 0 0 141 173 1 1
    EIF2AK2 IRGM 0 0 204 240 1 2
    EIF2AK2 MYC 66 0 188 264 1 2
    EIF2AK2 WFS1 0 0 81 187 1 1
    EIF2AK2 RTDR1 0 0 0 207 1 1
    EIF2AK2 MAP3K8 0 0 135 186 1 1
    EIF2AK2 CH25H 0 0 171 272 1 1
    EIF2AK2 DHX58 397 0 423 686 1 1
    EIF2AK2 HIST1H2AE 270 0 0 270 1 1
    EIF2AK2 OASL 0 0 509 662 1 1
    EIF2AK2 GRSF1 214 0 74 261 1 1
    EIF2AK2 IFITM2 0 0 298 298 1 1
    EIF2AK2 NFX1 0 0 60 205 1 1
    EIF2AK2 CD80 0 0 122 159 1 1
    EIF2AK2 ATCAY 0 0 89 297 1 1
    EIF2AK2 RPS19 0 0 50 511 1 1
    EIF2AK2 RB1CC1 0 0 134 157 1 2
    EIF2AK2 MECP2 179 0 0 179 1 1
    EIF2AK2 TLR1 0 0 150 217 1 1
    EIF2AK2 NFE2L2 0 800 91 810 1 1
    EIF2AK2 NHLRC2 299 0 125 374 1 1
    EIF2AK2 EIF2B5 0 0 398 411 1 1
    EIF2AK2 DRG2 0 0 0 171 1 1
    EIF2AK2 TAX1BP1 0 0 82 256 1 2
    EIF2AK2 NGDN 0 0 119 181 1 1
    EIF2AK2 CASP10 0 0 48 153 1 1
    EIF2AK2 HIPK4 0 0 108 315 1 1
    EIF2AK2 RPS25 0 0 66 442 1 1
    EIF2AK2 KRTCAP2 0 0 173 173 1 1
    EIF2AK2 PRSS57 0 0 82 176 1 1
    EIF2AK2 MRPL40 0 0 0 321 1 1
    EIF2AK2 EIF5B 0 0 84 299 1 1
    EIF2AK2 CCNT1 0 0 135 173 1 1
    EIF2AK2 PBK 0 0 45 310 1 1
    EIF2AK2 ARCN1 0 0 0 266 1 1
    EIF2AK2 PDZRN4 0 0 0 372 1 1
    EIF2AK2 OAS3 0 0 529 888 1 1
    EIF2AK2 ATF5 0 0 102 295 1 1
    EIF2AK2 TRIP12 0 0 70 377 1 1
    EIF2AK2 EIF1B 0 0 120 180 1 1
    EIF2AK2 AHSP 0 0 81 152 1 1
    EIF2AK2 GTPBP10 0 0 0 208 1 1
    EIF2AK2 RPS3 0 0 165 383 1 1
    EIF2AK2 ANXA5 0 0 112 205 1 1
    EIF2AK2 ZDHHC17 0 0 328 328 1 1
    EIF2AK2 NPPA 0 0 0 191 1 1
    EIF2AK2 G0S2 0 0 84 178 1 1
    EIF2AK2 CREB1 0 0 107 210 1 1
    EIF2AK2 USP9X 0 0 0 163 1 1
    EIF2AK2 TNFRSF17 0 0 145 163 1 1
    EIF2AK2 CCL5 0 0 186 219 1 1
    EIF2AK2 HIST2H2AC 270 0 0 270 1 1
    EIF2AK2 DHX9 480 0 153 610 1 1
    EIF2AK2 ZNFX1 0 0 181 571 1 1
    EIF2AK2 IFNG 0 0 218 353 1 2
    EIF2AK2 KHDRBS1 0 0 86 311 1 1
    EIF2AK2 IL2RB 0 0 74 249 1 1
    EIF2AK2 CREBBP 0 0 69 166 1 1
    EIF2AK2 MOV10 157 0 193 420 1 1
    EIF2AK2 PSMB1 0 0 0 260 1 1
    EIF2AK2 NFATC2IP 0 0 74 156 1 1
    EIF2AK2 PIEZO2 0 0 0 158 1 1
    EIF2AK2 PELI2 0 0 0 224 1 1
    EIF2AK2 MAP2K7 0 0 95 162 1 1
    EIF2AK2 PTBP1 0 0 100 166 1 1
    EIF2AK2 UBE2V2 0 0 0 170 1 1
    EIF2AK2 NMI 0 0 0 185 1 1
    EIF2AK2 GABARAPL2 65 0 108 190 1 2
    EIF2AK2 CD14 0 900 60 901 1 1
    EIF2AK2 POTEE 0 0 0 150 1 1
    EIF2AK2 SNW1 0 0 47 203 1 1
    EIF2AK2 OAS2 0 0 560 838 1 1
    EIF2AK2 USP47 0 0 53 174 1 1
    EIF2AK2 GAPDH 0 0 287 326 1 2
    EIF2AK2 ABCF1 0 0 66 327 1 1
    EIF2AK2 CYP1A1 271 0 0 271 1 1
    EIF2AK2 ATG14 0 0 431 431 1 2
    EIF2AK2 HDGF 270 0 0 291 1 1
    EIF2AK2 IL9R 0 0 108 175 1 1
    EIF2AK2 EPC2 0 0 0 167 1 1
    EIF2AK2 PML 0 0 141 175 1 1
    EIF2AK2 TLR4 0 900 307 934 1 1
    EIF2AK2 GDAP2 0 0 0 163 1 1
    EIF2AK2 RELA 0 0 194 273 1 1
    EIF2AK2 BCL2L1 0 0 143 250 1 2
    EIF2AK2 PRKRIP1 270 0 44 272 1 1
    EIF2AK2 ASGR2 0 0 93 183 1 1
    EIF2AK2 LIPM 0 0 0 157 1 1
    EIF2AK2 RPL13 0 0 0 286 1 1
    EIF2AK2 LGALS3BP 0 0 120 161 1 1
    EIF2AK2 CNOT1 0 0 0 156 1 1
    EIF2AK2 NFKB1 0 0 170 217 1 1
    EIF2AK2 STAT4 0 0 181 330 1 1
    EIF2AK2 LONRF2 0 0 0 151 1 1
    EIF2AK2 EVI5 0 0 134 302 1 1
    EIF2AK2 IGF2BP2 274 0 0 274 1 1
    EIF2AK2 PIK3R4 0 0 414 446 1 2
    EIF2AK2 TRIM25 0 900 381 939 1 1
    EIF2AK2 ZGLP1 0 0 0 153 1 1
    EIF2AK2 IKBKE 0 0 133 151 1 1
    EIF2AK2 HERC5 0 900 457 978 1 1
    EIF2AK2 XPO1 0 0 118 197 1 1
    EIF2AK2 SAMSN1 0 0 66 182 1 1
    EIF2AK2 PNPT1 0 0 181 301 1 1
    EIF2AK2 C3AR1 0 0 150 173 1 1
    EIF2AK2 EIF3I 0 0 0 386 1 1
    EIF2AK2 CDC73 0 0 47 175 1 1
    EIF2AK2 APP 0 0 104 188 1 1
    EIF2AK2 MFN2 0 0 54 150 1 2
    EIF2AK2 IFNA4 0 0 289 289 1 1
    EIF2AK2 ARV1 0 0 0 380 1 1
    EIF2AK2 PPP1R42 0 0 0 167 1 1
    EIF2AK2 HRAS 0 0 95 206 1 1
    EIF2AK2 RPL30 0 0 44 159 1 1
    EIF2AK2 TTC31 0 0 0 158 1 1
    EIF2AK2 CXCL8 0 0 232 237 1 1
    EIF2AK2 USP41 0 900 95 929 1 1
    EIF2AK2 SUMO2 270 0 0 336 1 1
    EIF2AK2 POLR1B 0 0 0 225 1 1
    EIF2AK2 IL1B 0 0 294 356 1 1
    EIF2AK2 PSMC2 0 0 57 329 1 1
    EIF2AK2 EDEM3 0 0 81 162 1 1
    EIF2AK2 WDR76 0 0 0 152 1 1
    EIF2AK2 CNBP 0 0 410 414 1 1
    EIF2AK2 HIF1A 0 0 108 171 1 2
    EIF2AK2 OAS1 0 0 661 754 1 1
    EIF2AK2 TRAF5 270 0 46 524 1 1
    EIF2AK2 RPL12 0 0 102 319 1 1
    EIF2AK2 RPS7 0 0 0 504 1 1
    EIF2AK2 SYVN1 0 0 134 221 1 1
    EIF2AK2 TNFRSF1A 0 0 155 169 1 1
    EIF2AK2 RPS6 0 0 58 532 1 1
    EIF2AK2 RPL32 0 0 49 152 1 1
    EIF2AK2 BATF2 0 0 0 168 1 1
    EIF2AK2 STAT1 486 300 529 933 1 1
    EIF2AK2 SNRPA 0 0 0 157 1 1
    EIF2AK2 CHD1L 0 0 0 153 1 1
    EIF2AK2 IL6 0 0 300 362 1 1
    EIF2AK2 TCF20 0 0 0 150 1 1
    EIF2AK2 CCDC124 157 0 0 266 1 1
    EIF2AK2 RPL9 0 0 0 286 1 1
    EIF2AK2 FARSA 157 0 0 219 1 1
    EIF2AK2 ATL1 0 0 193 228 1 1
    EIF2AK2 GSPT1 0 0 0 159 1 1
    EIF2AK2 ETS2 0 0 54 213 1 1
    EIF2AK2 PIK3C3 0 0 384 448 1 2
    EIF2AK2 JARID2 0 0 0 163 1 1
    EIF2AK2 PSMC6 0 0 0 154 1 1
    EIF2AK2 EVI5L 0 0 0 160 1 1
    EIF2AK2 ADAR 0 0 529 621 1 1
    EIF2AK2 POTEF 0 0 139 236 1 1
    EIF2AK2 DDX19A 0 0 0 286 1 1
    EIF2AK2 RPL13A 0 0 126 429 1 1
    EIF2AK2 APOBEC3G 0 0 181 182 1 1
    EIF2AK2 MTOR 0 0 182 314 1 2
    EIF2AK2 NLRP1 270 0 107 333 1 1
    EIF2AK2 LAP3 0 0 0 187 1 1
    EIF2AK2 ATF7-NPFF 0 0 0 168 1 1
    EIF2AK2 SPNS1 0 0 0 183 1 2
    EIF2AK2 PTPN13 0 0 45 160 1 1
    EIF2AK2 RPL14 0 0 0 232 1 1
    EIF2AK2 CT55 0 0 0 176 1 1
    EIF2AK2 TRAF4 0 0 0 372 1 1
    EIF2AK2 EIF5 0 0 150 309 1 1
    EIF2AK2 RCN2 0 0 0 187 1 1
    EIF2AK2 TSSC1 0 0 123 217 1 1
    EIF2AK2 TLR5 0 0 146 195 1 1
    EIF2AK2 RPL24 0 0 0 170 1 1
    EIF2AK2 RPAP3 0 0 0 169 1 1
    EIF2AK2 UBE2N 0 0 82 188 1 1
    EIF2AK2 CPB1 0 0 295 295 1 1
    EIF2AK2 IFNA7 0 0 150 150 1 1
    EIF2AK2 CPEB4 0 0 108 261 1 1
    EIF2AK2 IFNAR2 0 0 336 473 1 1
    EIF2AK2 EIF4G1 0 0 181 439 1 2
    EIF2AK2 PARP1 0 0 67 164 1 2
    EIF2AK2 HSPA8 0 0 74 217 1 2
    EIF2AK2 GIGYF2 0 0 0 160 1 1
    EIF2AK2 EIF3E 0 0 95 169 1 1
    EIF2AK2 TIMM17A 0 0 142 191 1 1
    EIF2AK2 MLKL 0 0 119 173 1 1
    EIF2AK2 TOMM34 0 0 0 179 1 1
    EIF2AK2 CMTR2 0 0 0 167 1 1
    EIF2AK2 RPL8 0 0 0 429 1 1
    EIF2AK2 EHHADH 0 900 0 900 1 1
    EIF2AK2 EPC1 0 0 0 167 1 1
    EIF2AK2 ZC3H15 0 0 0 284 1 1
    EIF2AK2 PTPRC 0 0 75 191 1 1
    EIF2AK2 IFIT5 0 0 414 629 1 1
    EIF2AK2 CLEC2D 0 0 107 162 1 1
    EIF2AK2 PRPF40B 0 0 352 357 1 1
    EIF2AK2 WDR82 0 0 69 185 1 1
    EIF2AK2 DHX57 0 0 0 170 1 1
    EIF2AK2 SP100 0 0 171 256 1 1
    EIF2AK2 RANGAP1 0 0 0 154 1 1
    EIF2AK2 RPL22 0 0 92 254 1 1
    EIF2AK2 ATF2 0 0 0 182 1 1
    EIF2AK2 ELF2 213 0 219 384 1 1
    EIF2AK2 ZNF689 0 0 167 243 1 1
    EIF2AK2 PDIA2 0 0 0 158 1 1
    EIF2AK2 HSP90AA1 394 0 150 540 1 2
    EIF2AK2 IFNA16 0 0 245 245 1 1
    EIF2AK2 FOSL1 0 0 0 168 1 1
    EIF2AK2 FRMPD3 0 0 150 300 1 1
    EIF2AK2 EIF2B1 0 0 143 349 1 1
    EIF2AK2 HPGDS 0 0 397 396 1 1
    EIF2AK2 KMT2C 0 0 0 172 1 1
    EIF2AK2 CUL4A 0 0 60 179 1 1
    EIF2AK2 MCM5 0 0 93 208 1 1
    EIF2AK2 PNPLA5 0 0 164 204 1 1
    EIF2AK2 B2M 0 0 151 170 1 1
    EIF2AK2 MAPK3 0 300 108 346 1 2
    EIF2AK2 TRANK1 0 0 74 236 1 1
    EIF2AK2 SQSTM1 0 0 136 252 1 2
    EIF2AK2 KHSRP 0 0 88 168 1 1
    EIF2AK2 FCGR2B 0 0 66 228 1 1
    EIF2AK2 CIT 270 0 0 274 1 1
    EIF2AK2 INS 0 0 181 211 1 1
    EIF2AK2 ATG13 0 0 100 174 1 2
    EIF2AK2 ACTB 0 0 260 344 1 1
    EIF2AK2 UBE2E1 0 300 106 361 1 1
    EIF2AK2 EDEM2 0 0 126 279 1 1
    EIF2AK2 CD40 0 0 113 164 1 1
    EIF2AK2 NLRX1 0 0 48 274 1 1
    EIF2AK2 GBP7 0 0 262 303 1 1
    EIF2AK2 RPS2 270 0 82 415 1 1
    EIF2AK2 SH2D3C 0 0 67 151 1 1
    EIF2AK2 GBP4 0 0 209 258 1 1
    EIF2AK2 TNFSF10 0 0 296 345 1 2
    EIF2AK2 HSPA1A 213 0 64 333 1 1
    EIF2AK2 CASP1 0 0 262 312 1 2
    EIF2AK2 PHF21A 0 0 0 162 1 1
    EIF2AK2 ALG13 0 0 0 151 1 1
    EIF2AK2 EIF2AK1 0 0 560 320 1 1
    EIF2AK2 DTX1 0 0 0 207 1 1
    EIF2AK2 CCNA2 303 0 75 362 1 1
    EIF2AK2 STRBP 213 0 764 834 1 1
    EIF2AK2 GRHL2 0 0 0 189 1 1
    EIF2AK2 CHEK1 0 0 67 152 1 1
    EIF2AK2 SNAP29 0 0 90 247 1 2
    EIF2AK2 RPL7 0 0 0 384 1 1
    EIF2AK2 TYK2 270 0 211 339 1 1
    EIF2AK2 UBE3C 0 0 0 185 1 1
    EIF2AK2 TMEM173 0 0 156 155 1 1
    EIF2AK2 TAPBP 0 0 135 207 1 1
    EIF2AK2 BATF 0 0 0 168 1 1
    EIF2AK2 JUN 129 0 286 451 1 1
    EIF2AK2 DIS3L 0 0 0 287 1 1
    EIF2AK2 ITPR3 0 0 90 151 1 1
    EIF2AK2 PLCG1 0 300 57 375 1 1
    EIF2AK2 DCAF10 0 0 0 189 1 1
    EIF2AK2 AMFR 0 0 95 161 1 1
    EIF2AK2 ENSG00000173366 0 0 261 303 1 1
    EIF2AK2 BCL2L11 0 0 142 327 1 1
    EIF2AK2 HNRNPA1 0 0 108 189 1 1
    EIF2AK2 IL10RA 0 0 460 460 1 1
    EIF2AK2 KPNB1 0 0 56 162 1 1
    EIF2AK2 DIS3L2 0 0 0 307 1 1
    EIF2AK2 KPNA6 0 0 0 165 1 1
    EIF2AK2 ERN2 0 0 161 194 1 1
    EIF2AK2 EIF1 0 0 129 268 1 1
    EIF2AK2 NOP2 157 0 0 156 1 1
    EIF2AK2 DNAJC3 486 900 551 984 1 1
    EIF2AK2 ARIH1 0 900 0 921 1 1
    EIF2AK2 RPL3 0 0 0 426 1 1
    EIF2AK2 IL7R 0 0 74 171 1 1
    EIF2AK2 RTP4 0 0 391 489 1 1
    EIF2AK2 PARP14 0 0 287 664 1 1
    EIF2AK2 DHX38 0 0 0 151 1 1
    EIF2AK2 DNA2 0 0 0 161 1 1
    EIF2AK2 GTPBP4 157 0 119 226 1 1
    EIF2AK2 LTA 0 0 94 185 1 1
    EIF2AK2 EIF3M 0 0 125 225 1 1
    EIF2AK2 RPL4 0 0 0 197 1 1
    EIF2AK2 CAPN2 0 0 137 217 1 2
    EIF2AK2 COPS2 0 0 0 198 1 1
    EIF2AK2 NCBP1 0 0 112 186 1 1
    EIF2AK2 NFKBIL1 0 0 134 161 1 1
    EIF2AK2 IFNK 0 0 112 211 1 1
    EIF2AK2 CREB3L2 0 0 45 155 1 1
    EIF2AK2 ADARB2 0 0 134 209 1 1
    EIF2AK2 PRPF40A 0 0 327 388 1 1
    EIF2AK2 SPATS2L 0 0 211 240 1 1
    EIF2AK2 PELI3 0 0 0 173 1 1
    EIF2AK2 TICAM1 0 0 225 258 1 1
    EIF2AK2 DCLRE1C 0 0 95 244 1 1
    EIF2AK2 PSMD1 0 0 0 252 1 1
    EIF2AK2 CREB3 0 0 96 158 1 1
    EIF2AK2 USP40 0 0 0 167 1 1
    EIF2AK2 IGF2BP3 274 0 74 298 1 1
    EIF2AK2 CTU1 0 0 75 234 1 1
    EIF2AK2 NEK3 0 0 108 155 1 1
    EIF2AK2 NDUFB2 0 0 125 175 1 1
    EIF2AK2 EIF3K 0 0 82 177 1 1
    EIF2AK2 CD8A 0 0 218 218 1 1
    EIF2AK2 IRS2 0 800 0 824 1 1
    EIF2AK2 APOBEC3A 0 0 180 179 1 1
    EIF2AK2 CALR 0 0 141 336 1 1
    EIF2AK2 SYNJ2BP 0 0 67 231 1 1
    EIF2AK2 PSMB8 0 0 291 323 1 1
    EIF2AK2 RSAD1 0 0 0 175 1 1
    EIF2AK2 PUM2 0 0 75 269 1 1
    EIF2AK2 XRN1 0 0 113 193 1 1
    EIF2AK2 API5 0 0 96 179 1 1
    EIF2AK2 PABPN1 0 0 295 311 1 1
    EIF2AK2 TRIM16L 0 0 137 169 1 1
    EIF2AK2 SERPING1 0 0 162 161 1 1
    EIF2AK2 USP24 0 0 0 163 1 1
    EIF2AK2 MAPK8 0 0 233 188 1 2
    EIF2AK2 EIF2S2 0 900 169 921 1 1
    EIF2AK2 MX2 0 500 542 823 1 1
    EIF2AK2 CISH 0 0 156 157 1 1
    EIF2AK2 PRNP 0 0 97 153 1 1
    EIF2AK2 SRPK1 0 0 0 200 1 1
    EIF2AK2 IFNA10 0 0 181 181 1 1
    EIF2AK2 PPP1R10 0 0 0 199 1 1
    EIF2AK2 H2AFY2 0 0 0 163 1 1
    EIF2AK2 RPS5 0 0 0 426 1 1
    EIF2AK2 IFIH1 0 0 562 736 1 1
    EIF2AK2 SNRNP70 129 0 0 163 1 1
    EIF2AK2 TUFM 0 0 61 223 1 1
    EIF2AK2 CHD5 0 0 0 162 1 1
    EIF2AK2 BATF3 0 0 0 221 1 1
    EIF2AK2 RPS27 0 0 0 433 1 1
    EIF2AK2 ZDHHC1 0 0 0 217 1 1
    EIF2AK2 CXCL9 0 0 171 204 1 1
    EIF2AK2 CSDE1 0 0 123 330 1 1
    EIF2AK2 NEK9 0 0 0 153 1 1
    EIF2AK2 HSP90B1 0 0 181 462 1 1
    EIF2AK2 ISG20 0 0 503 541 1 1
    EIF2AK2 ZUFSP 0 0 0 181 1 1
    EIF2AK2 POTEJ 0 0 0 150 1 1
    EIF2AK2 TRIM5 0 0 370 409 1 2
    EIF2AK2 DICER1 397 0 212 542 1 1
    EIF2AK2 RPL17 0 0 61 440 1 1
    EIF2AK2 PCBP2 0 0 123 194 1 1
    EIF2AK2 GATA4 0 0 0 153 1 2
    EIF2AK2 RPLP1 0 0 113 379 1 1
    EIF2AK2 HSPA4 0 0 134 215 1 1
    EIF2AK2 IRF2 0 0 294 314 1 1
    EIF2AK2 PELI1 0 0 53 233 1 1
    EIF2AK2 NFRKB 0 0 90 150 1 1
    EIF2AK2 EIF4A3 0 0 116 162 1 1
    EIF2AK2 SMARCA5 0 0 0 181 1 1
    EIF2AK2 IL17A 0 0 113 150 1 1
    EIF2AK2 DUSP12 0 0 117 276 1 1
    EIF2AK2 GCN1L1 0 0 71 565 1 1
    EIF2AK2 TLR7 0 0 390 437 1 1
    EIF2AK2 DHX36 0 0 83 185 1 1
    EIF2AK2 CXCL11 0 0 202 202 1 1
    EIF2AK2 ZNF7 0 0 95 190 1 1
    EIF2AK2 CASP9 0 0 124 258 1 1
    EIF2AK2 ITPR1 0 0 63 161 1 2
    EIF2AK2 DUS2 0 0 103 188 1 1
    EIF2AK2 CNOT7 0 0 167 314 1 1
    EIF2AK2 TRAF6 486 900 180 969 1 2
    EIF2AK2 ERO1L 0 0 108 221 1 1
    EIF2AK2 IFI44L 0 0 502 878 1 1
    EIF2AK2 TARBP2 689 0 184 777 1 1
    EIF2AK2 LRRC47 0 0 0 198 1 1
    EIF2AK2 MBNL3 0 0 500 499 1 1
    EIF2AK2 TNFRSF10A 0 0 66 169 1 1
    EIF2AK2 ROBO3 0 0 398 398 1 1
    EIF2AK2 IFNA6 0 0 294 294 1 1
    EIF2AK2 CRY2 0 0 0 398 1 1
    EIF2AK2 TMA7 0 0 0 159 1 1
    EIF2AK2 IL4 0 0 123 155 1 1
    EIF2AK2 CLUH 0 0 0 194 1 1
    EIF2AK2 SRP72 0 0 64 175 1 1
    EIF2AK2 PDGFRB 270 0 0 270 1 1
    EIF2AK2 ELAVL1 42 0 134 224 1 1
    EIF2AK2 ARMC4 0 0 0 207 1 1
    EIF2AK2 HERPUD1 0 0 170 221 1 1
    EIF2AK2 KCTD17 157 0 0 156 1 1
    EIF2AK2 USP28 0 0 0 188 1 1
    EIF2AK2 ZDHHC11B 0 0 0 217 1 1
    EIF2AK2 CASP7 213 0 155 368 1 1
    EIF2AK2 PHF11 0 0 95 284 1 1
    EIF2AK2 ILF3 766 0 547 904 1 1
    EIF2AK2 AOAH 0 0 81 249 1 1
    EIF2AK2 ALB 0 0 126 259 1 1
    EIF2AK2 PPM1G 0 0 0 185 1 1
    EIF2AK2 CASP8 213 0 235 449 1 2
    EIF2AK2 CDC37 129 0 0 157 1 1
    EIF2AK2 CCL2 0 0 244 253 1 2
    EIF2AK2 EIF4A1 0 0 218 421 1 1
    EIF2AK2 MCM4 0 0 63 177 1 1
    EIF2AK2 CREB3L3 0 0 66 267 1 1
    EIF2AK2 RPL19 0 0 0 412 1 1
    EIF2AK2 IDO1 0 0 125 157 1 1
    EIF2AK2 IFI6 0 0 454 744 1 1
    EIF2AK2 TRADD 131 0 113 202 1 1
    EIF2AK2 PPP1CB 0 0 128 189 1 1
    EIF2AK2 PNO1 0 0 0 152 1 1
    EIF2AK2 RPS12 0 0 0 426 1 1
    EIF2AK2 MAVS 270 0 456 611 1 1
    EIF2AK2 SPNS2 0 0 0 183 1 1
    EIF2AK2 MAGI3 0 0 67 152 1 1
    EIF2AK2 GBP1 0 0 451 527 1 1
    EIF2AK2 CCL4 0 0 167 185 1 1
    EIF2AK2 IL1A 0 0 167 167 1 1
    EIF2AK2 PPP2R5A 270 0 61 359 1 1
    EIF2AK2 ABCF2 0 0 0 255 1 1
    EIF2AK2 GATA1 0 0 0 153 1 1
    EIF2AK2 MORF4L2 0 0 0 181 1 1
    EIF2AK2 MB21D1 0 0 261 322 1 1
    EIF2AK2 EMC6 0 0 113 174 1 1
    EIF2AK2 XRN2 486 0 0 524 1 1
    EIF2AK2 RPL6 270 0 0 457 1 1
    EIF2AK2 TRIM21 0 0 204 345 1 1
    EIF2AK2 AIM2 270 0 234 435 1 1
    EIF2AK2 DDX58 0 300 594 798 1 1
    EIF2AK2 DDX41 0 0 84 228 1 1
    EIF2AK2 HYOU1 0 0 89 262 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0004676 Molecular Function 3-phosphoinositide-dependent protein kinase activity enables IEA
    GO:0004679 Molecular Function AMP-activated protein kinase activity enables IEA
    GO:0005524 Molecular Function ATP binding enables IEA
    GO:0004677 Molecular Function DNA-dependent protein kinase activity enables IEA
    GO:0003723 Molecular Function RNA binding enables HDA
    GO:0072518 Molecular Function Rho-dependent protein serine/threonine kinase activity enables IEA
    GO:0003725 Molecular Function double-stranded RNA binding enables IDA
    GO:0004694 Molecular Function eukaryotic translation initiation factor 2alpha kinase activity enables IBA
    GO:0004694 Molecular Function eukaryotic translation initiation factor 2alpha kinase activity enables IMP
    GO:0044024 Molecular Function histone H2AS1 kinase activity enables IEA
    GO:0072371 Molecular Function histone H2AS121 kinase activity enables IEA
    GO:1990244 Molecular Function histone H2AT120 kinase activity enables IEA
    GO:0035979 Molecular Function histone H2AXS139 kinase activity enables IEA
    GO:0044025 Molecular Function histone H2BS14 kinase activity enables IEA
    GO:0140823 Molecular Function histone H2BS36 kinase activity enables IEA
    GO:0035175 Molecular Function histone H3S10 kinase activity enables IEA
    GO:0044022 Molecular Function histone H3S28 kinase activity enables IEA
    GO:0140855 Molecular Function histone H3S57 kinase activity enables IEA
    GO:0035402 Molecular Function histone H3T11 kinase activity enables IEA
    GO:0072354 Molecular Function histone H3T3 kinase activity enables IEA
    GO:0140857 Molecular Function histone H3T45 kinase activity enables IEA
    GO:0035403 Molecular Function histone H3T6 kinase activity enables IEA
    GO:0044023 Molecular Function histone H4S1 kinase activity enables IEA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0016301 Molecular Function kinase activity enables IDA
    GO:0004715 Molecular Function non-membrane spanning protein tyrosine kinase activity enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0004672 Molecular Function protein kinase activity enables IDA
    GO:0004672 Molecular Function protein kinase activity enables IMP
    GO:0019888 Molecular Function protein phosphatase regulator activity enables TAS
    GO:0106310 Molecular Function protein serine kinase activity enables IEA
    GO:0004674 Molecular Function protein serine/threonine kinase activity enables TAS
    GO:0004711 Molecular Function ribosomal protein S6 kinase activity enables IEA
    GO:0140374 Biological Process antiviral innate immune response involved_in IDA
    GO:0034198 Biological Process cellular response to amino acid starvation involved_in IMP
    GO:0006338 Biological Process chromatin remodeling involved_in IEA
    GO:0051607 Biological Process defense response to virus involved_in IEP
    GO:0030968 Biological Process endoplasmic reticulum unfolded protein response involved_in IEA
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in IEA
    GO:0008285 Biological Process negative regulation of cell population proliferation involved_in TAS
    GO:0033689 Biological Process negative regulation of osteoblast proliferation involved_in IMP
    GO:0017148 Biological Process negative regulation of translation involved_in IBA
    GO:0017148 Biological Process negative regulation of translation involved_in IDA
    GO:0017148 Biological Process negative regulation of translation involved_in IMP
    GO:0045071 Biological Process negative regulation of viral genome replication involved_in IMP
    GO:0043410 Biological Process positive regulation of MAPK cascade involved_in IMP
    GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
    GO:0032722 Biological Process positive regulation of chemokine production involved_in ISS
    GO:0001819 Biological Process positive regulation of cytokine production involved_in ISS
    GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in ISS
    GO:0032874 Biological Process positive regulation of stress-activated MAPK cascade involved_in ISS
    GO:0046777 Biological Process protein autophosphorylation involved_in IDA
    GO:0046777 Biological Process protein autophosphorylation involved_in IMP
    GO:0006468 Biological Process protein phosphorylation involved_in IDA
    GO:1900225 Biological Process regulation of NLRP3 inflammasome complex assembly involved_in ISS
    GO:1901532 Biological Process regulation of hematopoietic progenitor cell differentiation involved_in ISS
    GO:1902036 Biological Process regulation of hematopoietic stem cell differentiation involved_in ISS
    GO:1902033 Biological Process regulation of hematopoietic stem cell proliferation involved_in ISS
    GO:0006446 Biological Process regulation of translational initiation involved_in IBA
    GO:0035455 Biological Process response to interferon-alpha involved_in IDA
    GO:0009615 Biological Process response to virus involved_in IMP
    GO:0006412 Biological Process translation involved_in IEA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm is_active_in IDA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0016020 Cellular Component membrane located_in HDA
    GO:0005654 Cellular Component nucleoplasm located_in TAS
    GO:0005634 Cellular Component nucleus is_active_in IBA
    GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IDA
    GO:0005840 Cellular Component ribosome located_in TAS
    Pathways
    Name DB ID
    ISG15 antiviral mechanism Reactome R-HSA-1169408
    Antiviral mechanism by IFN-stimulated genes Reactome R-HSA-1169410
    Cytokine Signaling in Immune system Reactome R-HSA-1280215
    Disease Reactome R-HSA-1643685
    Influenza Infection Reactome R-HSA-168255
    Immune System Reactome R-HSA-168256
    NS1 Mediated Effects on Host Pathways Reactome R-HSA-168276
    Inhibition of PKR Reactome R-HSA-169131
    Infectious disease Reactome R-HSA-5663205
    Interferon Signaling Reactome R-HSA-913531
    Viral Infection Pathways Reactome R-HSA-9824446
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Measles virus infection (WP4630) WikiPathways WP4630_r123414
    PDGFR-beta pathway (WP3972) WikiPathways WP3972_r108157
    Endoplasmic reticulum stress response in coronavirus infection (WP4861) WikiPathways WP4861_r124658
    Translation factors (WP107) WikiPathways WP107_r117851
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    Type II interferon signaling (WP619) WikiPathways WP619_r120967
    Type I interferon induction and signaling during SARS-CoV-2 infection (WP4868) WikiPathways WP4868_r124657
    Roles of ceramides in the development of insulin resistance (WP5181) WikiPathways WP5181_r124468
    Host-pathogen interaction of human coronaviruses - interferon induction (WP4880) WikiPathways WP4880_r124638
    Ebola virus infection in host (WP4217) WikiPathways WP4217_r120623
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_047445116 1 mRNA transcript variant X3 NC_000002 Reference
    XM_011532987 3 mRNA transcript variant X1 NC_000002 Reference
    NM_001135651 3 mRNA transcript variant 2 NC_000002 Reference
    XM_047445115 1 mRNA transcript variant X2 NC_000002 Reference
    NM_002759 4 mRNA transcript variant 1 NC_000002 Reference
    NM_001135652 2 mRNA transcript variant 3 NC_000002 Reference