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DIABLO

diablo IAP-binding mitochondrial protein
General Information
Name diablo IAP-binding mitochondrial protein
Alias
  • diablo IAP-binding mitochondrial protein
  • diablo homolog, mitochondrial
  • diablo-like protein
  • direct IAP-binding protein with low pI
  • second mitochondria-derived activator of caspase
Gene_family
organism Homo sapiens
entrez_id 56616
location 12q24.31
transcript_count 7
exon_count 8
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
    Stringdb Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in [...]
    nextProt Is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
DIABLO BioGRID XIAP GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Far Western; Protein-peptide; Proximity Label-MS; Reconstituted Complex
DIABLO BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID BRCA1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TRAF6 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DYRK2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TOMM6 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TOMM5 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID IKBIP GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID NUF2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MAP7D3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID COPS7B GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID SLC25A19 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID BIRC6 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Proximity Label-MS; Reconstituted Complex
DIABLO BioGRID TOMM22 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID POLE4 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID EXOC1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TMX3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DNAJC10 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID HSD17B11 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TMX2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID ATP2C1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID NCAPD3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID ASCC3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MLLT11 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TOMM40 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID YAP1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID IPO13 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID EIF4E2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID LATS1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
DIABLO BioGRID TRAF2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID PLRG1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MYO1B GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID HNRNPH2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID GOLGA4 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DMPK GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DBN1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID CDK5 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID BIRC2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex
DIABLO BioGRID GINS3 GeneID BioGRID Co-fractionation
DIABLO BioGRID CCAR1 GeneID BioGRID Co-fractionation
DIABLO BioGRID LARP7 GeneID BioGRID Co-fractionation
DIABLO BioGRID PDCD4 GeneID BioGRID Co-fractionation
DIABLO BioGRID FAF1 GeneID BioGRID Co-fractionation
DIABLO BioGRID NCKAP1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ATG7 GeneID BioGRID Co-fractionation
DIABLO BioGRID WASF2 GeneID BioGRID Co-fractionation
DIABLO BioGRID DDX46 GeneID BioGRID Co-fractionation
DIABLO BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID UTRN GeneID BioGRID Co-fractionation
DIABLO BioGRID PSMD2 GeneID BioGRID Co-fractionation
DIABLO BioGRID PSMC1 GeneID BioGRID Co-fractionation
DIABLO BioGRID POLA1 GeneID BioGRID Co-fractionation
DIABLO BioGRID HSP90AA1 GeneID BioGRID Co-fractionation
DIABLO BioGRID UBE2K GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DIABLO BioGRID CDC34 GeneID BioGRID Biochemical Activity
DIABLO BioGRID AURKA GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DYNLL2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DYNLL1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID YWHAG GeneID BioGRID Affinity Capture-MS; Co-fractionation
DIABLO BioGRID SNX27 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DIABLO GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex
DIABLO BioGRID KLF16 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TBK1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID ARMC8 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID PHB2 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
DIABLO BioGRID KLHL2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TANK GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MTFR1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Two-hybrid
DIABLO BioGRID BIRC3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DIABLO BioGRID OTUD1 GeneID BioGRID Affinity Capture-Western
DIABLO BioGRID BIRC8 GeneID BioGRID Affinity Capture-MS; Co-crystal Structure
DIABLO BioGRID RPF1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID BIRC7 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
DIABLO BioGRID GID4 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DUSP22 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TRAF1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID SLC1A3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MKLN1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID LTBR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
DIABLO BioGRID DNAJB2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID CXCL1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID GPX4 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID GFER GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
DIABLO BioGRID HTRA4 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID SFXN1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID AIFM1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CS GeneID BioGRID Proximity Label-MS
DIABLO BioGRID RBM39 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MIA3 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MTX3 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MICU2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID PGAM5 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TOM1L2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID APOOL GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CHCHD4 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID SNAP47 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID LACTB GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MTFR2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ADCK2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID RHOT2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CHCHD6 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ATAD3B GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CLPB GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NAA50 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MYO19 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID COA7 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CEP85 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MAVS GeneID BioGRID Proximity Label-MS
DIABLO BioGRID DNAJC11 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID IARS2 GeneID BioGRID Co-fractionation; Proximity Label-MS
DIABLO BioGRID EXD2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ATAD3A GeneID BioGRID Proximity Label-MS
DIABLO BioGRID PTCD3 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID OCIAD1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CHCHD3 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TTC19 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID LRRC49 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MRPS2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFA13 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ITSN2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID STOML2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID HTRA2 GeneID BioGRID Affinity Capture-Western; Far Western; Proximity Label-MS
DIABLO BioGRID RANBP6 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TIMM8B GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TIMM13 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ATXN10 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID SAMM50 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID PUM2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID PMPCA GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ABRAXAS2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID DHX30 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID IMMT GeneID BioGRID Proximity Label-MS
DIABLO BioGRID AFG3L2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID YME1L1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID YKT6 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MTX2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID HK1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID GPD2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID GOLGA3 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ENDOG GeneID BioGRID Proximity Label-MS
DIABLO BioGRID DLST GeneID BioGRID Proximity Label-MS
DIABLO BioGRID DHFR GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TIMM8A GeneID BioGRID Proximity Label-MS
DIABLO BioGRID DDOST GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CPOX GeneID BioGRID Proximity Label-MS
DIABLO BioGRID COX15 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID COX6B1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID COX4I1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CKMT1B GeneID BioGRID Proximity Label-MS
DIABLO BioGRID RERE GeneID BioGRID Proximity Label-MS
DIABLO BioGRID HAX1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TAB1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MICU1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MRPS31 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID FLOT1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ACTR2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID SCO2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID TOMM70 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID COX5A GeneID BioGRID Proximity Label-MS
DIABLO BioGRID SNAP29 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID SLC25A12 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MLF2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MAP3K7 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID VPS52 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID PHB1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
DIABLO BioGRID OPA1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFS8 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFS5 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFS3 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFS1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFB10 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFA8 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID NDUFA5 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MYO6 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MTX1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID COX2 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MLF1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID MKI67 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID IMMP1L GeneID BioGRID Proximity Label-MS
DIABLO BioGRID CAV2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID CUL7 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID AGTRAP GeneID BioGRID Two-hybrid
DIABLO BioGRID FKBP7 GeneID BioGRID Two-hybrid
DIABLO BioGRID TIMMDC1 GeneID BioGRID Two-hybrid
DIABLO BioGRID DERL2 GeneID BioGRID Two-hybrid
DIABLO BioGRID SEC22A GeneID BioGRID Two-hybrid
DIABLO BioGRID MPC2 GeneID BioGRID Two-hybrid
DIABLO BioGRID ARL6IP1 GeneID BioGRID Two-hybrid
DIABLO BioGRID SYP GeneID BioGRID Two-hybrid
DIABLO BioGRID DGAT2L6 GeneID BioGRID Two-hybrid
DIABLO BioGRID HSD17B13 GeneID BioGRID Two-hybrid
DIABLO BioGRID FADS6 GeneID BioGRID Two-hybrid
DIABLO BioGRID RMDN2 GeneID BioGRID Two-hybrid
DIABLO BioGRID CMTM4 GeneID BioGRID Two-hybrid
DIABLO BioGRID MICOS13 GeneID BioGRID Two-hybrid
DIABLO BioGRID DHRS1 GeneID BioGRID Two-hybrid
DIABLO BioGRID SFT2D1 GeneID BioGRID Two-hybrid
DIABLO BioGRID STMN4 GeneID BioGRID Two-hybrid
DIABLO BioGRID SLC66A2 GeneID BioGRID Two-hybrid
DIABLO BioGRID SLC17A9 GeneID BioGRID Two-hybrid
DIABLO BioGRID RHBDD2 GeneID BioGRID Two-hybrid
DIABLO BioGRID APOC4 GeneID BioGRID Two-hybrid
DIABLO BioGRID APOC2 GeneID BioGRID Two-hybrid
DIABLO BioGRID UBC GeneID BioGRID Proximity Label-MS
DIABLO BioGRID ITFG1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DNAJC5 GeneID BioGRID Co-fractionation
DIABLO BioGRID GRPEL1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ATPAF1 GeneID BioGRID Co-fractionation
DIABLO BioGRID AARS2 GeneID BioGRID Co-fractionation
DIABLO BioGRID TIMM44 GeneID BioGRID Co-fractionation
DIABLO BioGRID MMP20 GeneID BioGRID Co-fractionation
DIABLO BioGRID YWHAZ GeneID BioGRID Co-fractionation
DIABLO BioGRID YWHAH GeneID BioGRID Co-fractionation
DIABLO BioGRID YWHAE GeneID BioGRID Co-fractionation
DIABLO BioGRID VBP1 GeneID BioGRID Co-fractionation
DIABLO BioGRID UBA1 GeneID BioGRID Co-fractionation
DIABLO BioGRID RAD23A GeneID BioGRID Co-fractionation
DIABLO BioGRID PFDN4 GeneID BioGRID Co-fractionation
DIABLO BioGRID PAFAH2 GeneID BioGRID Co-fractionation
DIABLO BioGRID NDUFAB1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ATXN3 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID LDHB GeneID BioGRID Co-fractionation
DIABLO BioGRID FH GeneID BioGRID Co-fractionation
DIABLO BioGRID BMH1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
DIABLO BioGRID BMH2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID ECH1 GeneID BioGRID Co-fractionation
DIABLO BioGRID CAPNS1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ATIC GeneID BioGRID Co-fractionation
DIABLO BioGRID ALDH9A1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ALDH1B1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ALDH2 GeneID BioGRID Co-fractionation
DIABLO BioGRID ACADM GeneID BioGRID Co-fractionation
DIABLO BioGRID E2F1 GeneID BioGRID Protein-peptide
DIABLO BioGRID EEA1 GeneID BioGRID Proximity Label-MS
DIABLO BioGRID RNF41 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID TNIP2 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID BIRC5 GeneID BioGRID Affinity Capture-Western; FRET; Reconstituted Complex
DIABLO BioGRID ORF10 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID DLD GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID MTMR14 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID LIMA1 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID SURF2 GeneID BioGRID Co-fractionation
DIABLO BioGRID PRKCD GeneID BioGRID Affinity Capture-Western
DIABLO BioGRID CD40 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
DIABLO BioGRID GABPA GeneID BioGRID Co-fractionation
DIABLO BioGRID AP1B1 GeneID BioGRID Co-fractionation
DIABLO BioGRID SSRP1 GeneID BioGRID Co-fractionation
DIABLO BioGRID ABCE1 GeneID BioGRID Co-fractionation
DIABLO BioGRID GMPPB GeneID BioGRID Co-fractionation
DIABLO BioGRID LIMCH1 GeneID BioGRID Co-fractionation
DIABLO BioGRID AREL1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
DIABLO BioGRID SLC25A47 GeneID BioGRID Two-hybrid
DIABLO BioGRID MAML2 GeneID BioGRID Two-hybrid
DIABLO BioGRID UBL4A GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID NR4A1 GeneID BioGRID Two-hybrid
DIABLO BioGRID ARNT GeneID BioGRID Two-hybrid
DIABLO BioGRID MALT1 GeneID BioGRID Affinity Capture-Western
DIABLO BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
DIABLO BioGRID ZNF746 GeneID BioGRID Two-hybrid
DIABLO BioGRID TOLLIP GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID UFM1 GeneID BioGRID Two-hybrid
DIABLO BioGRID EEF1A1 GeneID BioGRID Two-hybrid
DIABLO BioGRID Bex3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
DIABLO BioGRID USP13 GeneID BioGRID Affinity Capture-MS
DIABLO Protein HTRA2 GeneID HPRD
DIABLO Protein BIRC7 GeneID HPRD
DIABLO Protein BIRC6 GeneID HPRD
DIABLO Protein DIABLO GeneID HPRD
DIABLO Protein BIRC5 GeneID HPRD
DIABLO Protein CASP9 GeneID HPRD
DIABLO Protein BIRC2 GeneID HPRD
DIABLO Protein BIRC3 GeneID HPRD
DIABLO Protein LTBR GeneID HPRD
DIABLO Protein BEX3 GeneID HPRD
DIABLO Protein XIAP GeneID HPRD
DIABLO BioGRID TNFSF14 GeneID BioGRID Affinity Capture-MS
DIABLO BioGRID NAIP GeneID BioGRID Affinity Capture-Western
DIABLO Protein XIAP GeneID BIND XIAP interacts with and ubiquitinates SMAC.
DIABLO Protein BIRC6 GeneID BIND Apollon interacts with and ubiquitinates SMAC.
DIABLO Protein XIAP GeneID BIND Smac interacts with XIAP.
DIABLO Protein BIRC6 GeneID BIND BRUCE interacts with SMAC.
DIABLO Protein BEX3 GeneID BIND An unspecified isoform of NADE interacts with Smac. This interaction was modelled on a demonstrated interaction between mouse NADE and human Smac.
DIABLO Protein LTBR GeneID BIND Smac interacts with LTBR.
StringDB
A B experiments database textmining combined score hadb nhadb
DIABLO ITGB2 0 0 144 163 1 1
DIABLO KRAS 0 0 312 355 1 2
DIABLO FOXO1 0 0 203 203 1 2
DIABLO CDK9 0 0 174 173 1 1
DIABLO SOD2 0 0 269 284 1 2
DIABLO DNM1 0 0 90 156 1 1
DIABLO HSPA5 0 0 296 296 1 2
DIABLO E2F1 270 0 156 357 1 2
DIABLO CASP14 0 0 150 220 1 1
DIABLO ITFG1 270 0 0 270 1 1
DIABLO BTRC 0 0 137 155 1 1
DIABLO HAX1 98 0 357 417 1 1
DIABLO BIRC7 870 0 983 998 1 1
DIABLO TMEM11 0 0 0 488 1 1
DIABLO STAT5A 0 0 207 207 1 1
DIABLO IRAK3 0 0 74 181 1 1
DIABLO XAF1 0 0 529 529 1 1
DIABLO TNIP2 118 0 81 154 1 1
DIABLO FOS 0 0 167 167 1 2
DIABLO FASLG 0 0 620 620 1 1
DIABLO YWHAZ 115 0 108 178 1 1
DIABLO VBP1 128 0 0 171 1 1
DIABLO ACAT2 0 0 45 192 1 1
DIABLO SHARPIN 0 0 335 349 1 1
DIABLO DAD1 0 0 0 166 1 1
DIABLO NOD1 0 0 216 217 1 2
DIABLO CARD11 0 0 269 269 1 1
DIABLO CD86 0 0 184 183 1 1
DIABLO WAS 0 0 260 260 1 1
DIABLO BGN 0 0 0 252 1 1
DIABLO PMAIP1 0 0 681 681 1 2
DIABLO CERS6 0 0 123 166 1 1
DIABLO TLR2 0 0 161 161 1 2
DIABLO MAPK11 0 0 66 164 1 1
DIABLO MET 0 0 307 319 1 2
DIABLO TRAF3 0 540 459 740 1 2
DIABLO PHB 365 0 243 512 1 1
DIABLO TOLLIP 157 0 43 158 1 1
DIABLO HSH2D 0 0 195 195 1 1
DIABLO OTUD7B 0 0 154 153 1 1
DIABLO ABCB1 0 0 181 181 1 2
DIABLO BECN1 0 0 379 399 1 2
DIABLO COX4I2 0 0 206 227 1 1
DIABLO IL2 0 0 321 321 1 1
DIABLO CYBB 0 0 134 152 1 2
DIABLO CD28 0 0 431 446 1 1
DIABLO OMA1 0 0 170 189 1 1
DIABLO PPIA 0 0 447 478 1 1
DIABLO PPM1B 0 0 151 194 1 1
DIABLO ALOX5 0 0 82 213 1 1
DIABLO TNFSF13B 0 0 170 169 1 1
DIABLO PRKCQ 0 0 325 550 1 2
DIABLO ATG12 0 0 215 215 1 2
DIABLO RANBP6 117 0 0 173 1 1
DIABLO TNFRSF10B 0 0 667 700 1 2
DIABLO DAXX 0 0 247 246 1 1
DIABLO TNFRSF21 0 0 293 293 1 1
DIABLO VPS29 0 0 0 311 1 1
DIABLO PTGS2 0 0 241 240 1 2
DIABLO CASP3 0 600 838 942 1 2
DIABLO WASF2 0 0 205 205 1 1
DIABLO NQO1 0 0 159 174 1 2
DIABLO HSPA1B 0 0 72 169 1 1
DIABLO REL 0 0 310 312 1 2
DIABLO NLRP3 0 0 242 241 1 2
DIABLO TXNRD2 0 0 89 160 1 1
DIABLO LTBR 270 0 346 502 1 1
DIABLO PHB2 96 0 693 721 1 1
DIABLO HDAC1 0 0 181 181 1 2
DIABLO RIPK1 0 0 710 717 1 2
DIABLO TG 0 0 49 153 1 1
DIABLO TSPO 0 0 193 193 1 1
DIABLO NOD2 0 0 258 258 1 2
DIABLO SMPD1 0 0 329 329 1 1
DIABLO TXNRD1 0 0 95 154 1 1
DIABLO DHFR 116 0 155 230 1 1
DIABLO NRM 0 0 0 545 1 1
DIABLO MT-CO2 96 0 154 202 1 1
DIABLO RIN1 0 0 61 280 1 1
DIABLO KLF2 0 0 322 321 1 1
DIABLO CHUK 0 540 425 736 1 1
DIABLO CUL3 0 0 215 228 1 2
DIABLO CDKN2A 0 0 271 271 1 2
DIABLO CASP4 0 0 358 362 1 2
DIABLO MTCH2 0 0 154 172 1 1
DIABLO GSK3B 0 0 181 228 1 2
DIABLO TNFRSF10C 0 0 405 465 1 1
DIABLO CTSD 0 0 184 183 1 2
DIABLO PON2 0 0 181 237 1 1
DIABLO EZR 0 0 155 159 1 1
DIABLO ATM 0 0 288 296 1 2
DIABLO TOMM70A 117 0 128 231 1 1
DIABLO SHC1 0 0 125 157 1 1
DIABLO MDM4 0 0 170 169 1 1
DIABLO ATG7 0 0 260 262 1 2
DIABLO AREL1 270 0 280 451 1 1
DIABLO ACTG1 0 0 137 176 1 1
DIABLO ABCE1 244 0 0 243 1 1
DIABLO NCK1 0 0 209 212 1 1
DIABLO IL10 0 0 212 212 1 2
DIABLO UBE2S 0 0 156 155 1 1
DIABLO FMN1 0 0 155 154 1 1
DIABLO FLT3 0 0 189 189 1 2
DIABLO STRADB 0 0 416 416 1 1
DIABLO ENSG00000249590 0 0 0 188 1 1
DIABLO VEGFA 0 0 328 328 1 2
DIABLO TXN2 0 0 125 216 1 1
DIABLO MAPK7 0 0 135 151 1 1
DIABLO SGSM1 0 0 0 207 1 1
DIABLO PTEN 0 0 369 369 1 2
DIABLO GINS2 0 0 70 157 1 1
DIABLO TRAF7 0 0 206 206 1 1
DIABLO CASP5 0 0 167 173 1 1
DIABLO DNM1L 0 0 403 477 1 2
DIABLO CLIC4 0 0 107 179 1 1
DIABLO B4GALNT4 0 0 74 174 1 1
DIABLO SKAP1 0 0 242 259 1 1
DIABLO UBE2M 0 0 120 174 1 1
DIABLO APOOL 97 0 134 308 1 1
DIABLO SYK 0 0 218 233 1 2
DIABLO KIT 0 0 167 167 1 2
DIABLO NFKBIA 0 0 504 504 1 2
DIABLO CFL1 0 0 175 181 1 1
DIABLO TNFRSF9 0 0 150 169 1 1
DIABLO LMNB2 0 0 202 202 1 1
DIABLO MAPK14 0 0 241 408 1 2
DIABLO BAG1 0 0 210 227 1 2
DIABLO TP53BP2 0 0 133 264 1 2
DIABLO MAPK10 0 0 193 193 1 2
DIABLO NOX1 0 0 157 156 1 1
DIABLO LMNB1 0 0 202 208 1 1
DIABLO CTSB 0 0 235 235 1 2
DIABLO ECI1 0 0 0 305 1 1
DIABLO SIRT1 0 0 234 234 1 2
DIABLO RNF146 0 0 71 168 1 1
DIABLO ST8SIA2 0 0 391 456 1 1
DIABLO MCL1 0 0 688 707 1 2
DIABLO MAP3K5 0 0 403 403 1 1
DIABLO ITGAM 0 0 171 171 1 1
DIABLO LYN 0 0 162 176 1 1
DIABLO DFNA5 0 0 194 194 1 1
DIABLO ESR1 0 0 232 231 1 2
DIABLO HMGB1 0 0 244 243 1 2
DIABLO LIMCH1 244 0 0 243 1 1
DIABLO IFNB1 0 0 285 284 1 1
DIABLO ATG5 0 0 293 293 1 2
DIABLO BCL2L14 0 0 193 193 1 1
DIABLO CAMTA2 0 0 0 302 1 1
DIABLO CAPNS1 128 0 82 195 1 2
DIABLO XBP1 0 0 195 195 1 2
DIABLO NDUFA8 117 0 0 197 1 1
DIABLO GALC 0 0 327 327 1 1
DIABLO TGFBR1 0 0 0 181 1 1
DIABLO VAV1 0 0 325 326 1 1
DIABLO SURF2 272 0 0 272 1 1
DIABLO HSPB1 0 0 406 406 1 2
DIABLO HSPB2 0 0 403 403 1 1
DIABLO ANXA6 0 0 0 189 1 1
DIABLO DFFB 0 0 558 560 1 1
DIABLO MAP1LC3B 0 0 210 220 1 2
DIABLO HMOX2 0 0 162 168 1 1
DIABLO SPHK1 0 0 218 218 1 2
DIABLO RPS6KA1 0 0 128 168 1 1
DIABLO MAP3K12 0 0 181 181 1 1
DIABLO PRKCA 0 0 165 165 1 1
DIABLO FN1 0 0 203 203 1 2
DIABLO MT-CO1 0 0 162 180 1 1
DIABLO IKBKG 0 0 468 468 1 1
DIABLO DYNLL2 183 0 0 197 1 1
DIABLO SPN 0 0 212 212 1 1
DIABLO TNFAIP3 0 0 151 150 1 2
DIABLO NFKB2 0 0 420 420 1 1
DIABLO CD70 0 0 113 174 1 1
DIABLO MAP3K14 0 0 204 204 1 1
DIABLO TNFSF14 270 0 61 285 1 1
DIABLO BMF 0 0 502 505 1 1
DIABLO BCL2A1 0 0 427 426 1 1
DIABLO RELB 0 0 380 380 1 2
DIABLO FGF2 0 0 193 193 1 2
DIABLO GLRX2 0 0 117 155 1 1
DIABLO BCAP31 0 0 217 234 1 1
DIABLO GADD45A 0 0 195 276 1 1
DIABLO RNF41 270 0 605 699 1 1
DIABLO BTK 0 0 135 150 1 1
DIABLO MTFR1 393 0 0 392 1 1
DIABLO MAPK1 0 0 195 370 1 2
DIABLO IGF1 0 0 256 256 1 2
DIABLO SRR 0 0 0 214 1 1
DIABLO C22orf29 0 0 635 635 1 1
DIABLO LAT 0 0 281 281 1 1
DIABLO PTRH2 0 0 158 188 1 1
DIABLO TNF 0 0 614 640 1 2
DIABLO CASP2 0 0 595 596 1 1
DIABLO CD44 0 0 183 183 1 2
DIABLO USP5 0 0 433 435 1 1
DIABLO ITK 0 0 157 171 1 1
DIABLO GFER 130 0 92 176 1 1
DIABLO BAHD1 0 0 0 210 1 1
DIABLO NAIP 270 0 664 779 1 1
DIABLO VCL 0 0 171 171 1 1
DIABLO FIS1 0 0 395 408 1 2
DIABLO SMPD2 0 0 181 181 1 1
DIABLO PPP1R15A 0 0 150 182 1 2
DIABLO CHCHD5 0 0 120 159 1 1
DIABLO CTLA4 0 0 402 402 1 2
DIABLO DFFA 0 0 507 507 1 1
DIABLO BCL2 0 900 315 932 1 2
DIABLO BAK1 0 900 459 946 1 2
DIABLO ANXA7 0 0 0 204 1 1
DIABLO AVEN 0 0 150 179 1 1
DIABLO KIF23 0 0 386 386 1 1
DIABLO MICU2 117 0 95 166 1 1
DIABLO CCDC174 0 0 44 304 1 1
DIABLO TXN 0 0 248 270 1 1
DIABLO CANX 0 0 167 167 1 2
DIABLO LCP1 0 0 142 163 1 1
DIABLO CAST 0 0 184 183 1 2
DIABLO HRK 0 0 505 508 1 1
DIABLO SAP18 0 0 0 183 1 1
DIABLO FH 128 0 95 177 1 1
DIABLO NDUFA13 97 0 124 197 1 1
DIABLO CYC1 0 0 166 194 1 1
DIABLO CACYBP 0 0 71 307 1 1
DIABLO HTRA4 270 0 0 294 1 1
DIABLO CAT 0 0 373 373 1 2
DIABLO LEPREL2 0 0 134 152 1 1
DIABLO CRBN 0 0 141 194 1 1
DIABLO CDK1 0 0 308 315 1 2
DIABLO REM1 0 0 0 189 1 1
DIABLO BAD 0 0 359 373 1 2
DIABLO RPS6KB1 0 0 219 219 1 2
DIABLO UBL4A 270 0 0 270 1 1
DIABLO CBL 0 0 183 183 1 1
DIABLO HSPA9 0 0 288 290 1 1
DIABLO CHCHD4 117 0 202 308 1 1
DIABLO IFT43 0 0 322 321 1 1
DIABLO NTRK1 0 0 124 226 1 1
DIABLO ATR 0 0 95 174 1 2
DIABLO CD19 0 0 193 193 1 1
DIABLO STX2 0 0 506 640 1 1
DIABLO BCL2L2 0 0 612 612 1 1
DIABLO ANXA2 0 0 57 157 1 1
DIABLO IRAK2 0 0 57 216 1 1
DIABLO GRAMD4 0 0 244 243 1 1
DIABLO COPB1 0 0 321 335 1 1
DIABLO NOS3 0 0 194 194 1 2
DIABLO TNFRSF10D 0 0 407 466 1 1
DIABLO CCND1 0 0 365 365 1 2
DIABLO CD274 0 0 189 189 1 2
DIABLO VDAC3 0 0 323 350 1 1
DIABLO FOXO3 0 0 242 241 1 2
DIABLO EGR4 0 0 0 261 1 1
DIABLO EEA1 129 0 75 159 1 2
DIABLO XRCC6BP1 0 0 66 264 1 1
DIABLO ACIN1 0 0 52 158 1 1
DIABLO MCU 0 0 294 294 1 2
DIABLO LRP8 0 0 203 203 1 1
DIABLO CDC42 0 0 257 274 1 2
DIABLO USP8 0 0 457 457 1 1
DIABLO DAP3 0 0 134 166 1 1
DIABLO SRC 0 0 363 374 1 2
DIABLO SLC25A5 0 0 57 202 1 1
DIABLO DNAJB1 0 0 134 189 1 2
DIABLO ATG3 0 0 164 186 1 2
DIABLO BIRC6 871 0 755 971 1 1
DIABLO CDKN3 0 0 170 169 1 1
DIABLO TLR3 0 0 320 319 1 2
DIABLO TNFSF12 0 0 322 321 1 1
DIABLO RTN3 0 0 57 202 1 1
DIABLO ARL6IP1 274 0 0 274 1 1
DIABLO HTR2A 0 0 134 193 1 1
DIABLO EIF2AK3 0 0 314 313 1 2
DIABLO PPWD1 0 0 73 172 1 1
DIABLO TCHP 0 0 324 323 1 1
DIABLO TBK1 0 0 171 185 1 2
DIABLO HMOX1 0 0 218 218 1 2
DIABLO MTFP1 0 0 90 346 1 1
DIABLO EIF2S1 0 0 255 258 1 2
DIABLO TOMM20 0 0 392 449 1 2
DIABLO VDAC1 0 0 543 552 1 2
DIABLO RASSF5 0 0 184 183 1 1
DIABLO GADD45G 0 0 75 405 1 1
DIABLO STAT5B 0 0 193 193 1 1
DIABLO GHITM 0 0 81 249 1 1
DIABLO GLUL 0 0 106 345 1 1
DIABLO BNIP3L 0 0 245 244 1 2
DIABLO CDCA8 0 0 248 248 1 1
DIABLO PRKCD 270 0 894 919 1 2
DIABLO CD2 0 0 245 244 1 1
DIABLO CDKN1B 0 0 232 233 1 2
DIABLO TIMM8A 117 0 231 312 1 1
DIABLO USP7 0 0 167 173 1 1
DIABLO RIPK3 0 0 665 678 1 2
DIABLO RB1 0 0 170 169 1 2
DIABLO MKI67 270 0 0 315 1 2
DIABLO CSF2 0 0 212 212 1 1
DIABLO UBE3A 0 0 141 157 1 1
DIABLO PPARG 0 0 167 167 1 2
DIABLO TMEM151B 0 0 126 262 1 1
DIABLO AKT1 0 0 559 566 1 2
DIABLO CAPN1 0 0 161 176 1 2
DIABLO VCAM1 0 0 150 168 1 1
DIABLO CD4 0 0 375 375 1 2
DIABLO DERL2 273 0 0 273 1 1
DIABLO FAS 0 0 601 606 1 2
DIABLO CARD8 0 0 172 256 1 1
DIABLO ATF6 0 0 232 231 1 2
DIABLO SLC25A26 0 0 275 324 1 1
DIABLO NLRC4 0 0 181 181 1 2
DIABLO IKBKB 0 540 421 730 1 2
DIABLO LETM1 0 0 150 181 1 1
DIABLO CD247 0 0 398 398 1 1
DIABLO XIAP 992 900 989 999 1 2
DIABLO EIF2B2 0 0 0 159 1 1
DIABLO PARL 0 0 498 527 1 1
DIABLO PPP2R4 0 0 180 179 1 1
DIABLO SLC25A3 0 0 74 163 1 1
DIABLO KCNJ6 0 0 576 576 1 1
DIABLO CD58 0 0 180 179 1 1
DIABLO BIRC5 879 0 455 940 1 2
DIABLO SIRT4 0 0 108 169 1 1
DIABLO CASC1 0 0 66 372 1 1
DIABLO PINK1 0 0 264 264 1 2
DIABLO GPT 0 0 230 229 1 1
DIABLO MALT1 270 0 419 558 1 1
DIABLO P4HA3 0 0 48 644 1 1
DIABLO CYLD 0 0 503 503 1 1
DIABLO KRT18 0 0 181 186 1 1
DIABLO MTX2 117 0 128 215 1 1
DIABLO BIRC8 755 0 561 965 1 1
DIABLO TIMM13 117 0 71 164 1 1
DIABLO HSP90AB1 0 0 0 191 1 2
DIABLO P4HA1 0 0 0 303 1 1
DIABLO IMMP1L 0 0 729 729 1 1
DIABLO TLR9 0 0 176 175 1 2
DIABLO YME1L1 117 0 125 208 1 1
DIABLO MAP3K1 0 0 183 183 1 1
DIABLO PYCARD 0 0 181 182 1 2
DIABLO SPG21 0 0 430 430 1 1
DIABLO AIFM1 97 0 235 722 1 1
DIABLO TNFSF8 0 0 158 157 1 1
DIABLO ACVR1B 0 0 0 154 1 1
DIABLO BBC3 0 0 423 422 1 2
DIABLO DENR 0 0 233 257 1 1
DIABLO IRF3 0 0 230 252 1 2
DIABLO CD34 0 0 208 208 1 2
DIABLO PRDX3 0 0 113 150 1 1
DIABLO NGF 0 0 241 240 1 2
DIABLO ERBB2 0 0 314 313 1 2
DIABLO TNFRSF8 0 0 166 165 1 1
DIABLO TFAM 0 0 202 222 1 2
DIABLO RIPK2 0 0 265 294 1 2
DIABLO CRK 0 0 276 276 1 1
DIABLO MMP2 0 0 161 161 1 2
DIABLO TNFRSF13C 0 0 167 167 1 1
DIABLO MFN1 0 0 348 373 1 2
DIABLO HAVCR2 0 0 444 444 1 1
DIABLO SEPT4 0 0 293 293 1 1
DIABLO CD8A 0 0 371 371 1 1
DIABLO BIK 0 0 455 455 1 2
DIABLO CALR 0 0 243 242 1 1
DIABLO CD69 0 0 150 172 1 1
DIABLO EIF3M 0 0 514 521 1 1
DIABLO CDC25C 0 0 164 165 1 2
DIABLO SOD1 0 0 182 208 1 2
DIABLO LTA 0 0 112 206 1 1
DIABLO STOML2 111 0 87 187 1 1
DIABLO GRB2 0 0 183 184 1 1
DIABLO TICAM1 0 0 193 193 1 2
DIABLO FYN 0 0 243 256 1 1
DIABLO CAPN2 0 0 139 234 1 2
DIABLO YWHAE 128 0 73 172 1 1
DIABLO LCK 0 0 506 515 1 1
DIABLO MGRN1 0 0 60 207 1 1
DIABLO JUN 0 0 470 481 1 2
DIABLO ITPR3 0 0 261 261 1 1
DIABLO RHOT1 0 0 140 156 1 1
DIABLO PLCG1 0 0 388 388 1 1
DIABLO DAPK1 0 0 181 200 1 2
DIABLO UBA6 0 0 88 155 1 1
DIABLO BCL2L11 0 0 686 711 1 2
DIABLO ITGAL 0 0 212 212 1 1
DIABLO C7orf55 200 0 0 200 1 1
DIABLO ENSG00000173366 0 0 166 165 1 1
DIABLO TNFSF10 0 0 837 837 1 2
DIABLO HSPA1A 0 0 145 235 1 1
DIABLO BOK 0 0 390 431 1 1
DIABLO MAP2K3 0 0 150 165 1 1
DIABLO CHEK1 0 0 240 239 1 2
DIABLO DNTT 0 0 359 369 1 1
DIABLO SNCA 0 0 167 167 1 2
DIABLO CASP1 0 0 451 456 1 2
DIABLO CCNA2 0 0 256 256 1 1
DIABLO BNIP3 0 0 391 390 1 2
DIABLO SQSTM1 0 0 203 203 1 2
DIABLO ANXA4 0 0 0 189 1 1
DIABLO SIRT3 0 0 124 161 1 2
DIABLO MMP9 0 0 208 208 1 2
DIABLO KEAP1 0 0 167 167 1 2
DIABLO MAPK3 0 0 323 374 1 2
DIABLO FSBP 0 0 82 420 1 1
DIABLO CD40 270 540 287 739 1 2
DIABLO DLST 108 0 0 151 1 1
DIABLO STUB1 0 0 155 162 1 2
DIABLO GRAP2 0 0 161 161 1 1
DIABLO INS 0 0 276 276 1 2
DIABLO ACTB 0 0 518 542 1 2
DIABLO AK2 0 0 181 221 1 1
DIABLO COX4I1 94 0 504 568 1 1
DIABLO PSEN1 0 0 134 290 1 2
DIABLO TP73 0 0 82 173 1 2
DIABLO SGPL1 0 0 0 189 1 1
DIABLO HTRA2 486 540 856 966 1 1
DIABLO MBOAT1 0 0 0 230 1 1
DIABLO EIF2B1 0 0 43 373 1 1
DIABLO MLNR 0 0 0 189 1 1
DIABLO HPGDS 0 0 210 210 1 1
DIABLO HSP90AA1 0 0 403 403 1 2
DIABLO ICAM1 0 0 877 877 1 2
DIABLO BCORL1 0 0 0 199 1 1
DIABLO FYB 0 0 181 181 1 1
DIABLO PTPRC 0 0 310 309 1 1
DIABLO MLKL 0 0 681 691 1 2
DIABLO BCL10 0 0 332 332 1 1
DIABLO SMDT1 0 0 163 175 1 1
DIABLO CXCL12 0 0 134 193 1 2
DIABLO CCL18 0 0 0 250 1 1
DIABLO BAX 0 900 559 954 1 2
DIABLO UBE2N 0 0 187 221 1 1
DIABLO AURKA 0 0 146 182 1 2
DIABLO IMMP2L 0 0 739 739 1 1
DIABLO STX1A 0 0 419 455 1 1
DIABLO TOMM40 0 0 182 181 1 1
DIABLO GSN 0 0 165 165 1 1
DIABLO AR 0 0 187 187 1 2
DIABLO PARP1 0 0 380 422 1 2
DIABLO BID 0 0 563 563 1 2
DIABLO HSPA8 0 0 150 210 1 2
DIABLO SPO11 0 0 0 207 1 1
DIABLO GSR 0 0 157 156 1 1
DIABLO OAT 0 0 433 433 1 1
DIABLO CDKN1A 0 0 342 342 1 2
DIABLO BCL2L13 0 0 218 221 1 2
DIABLO IDH1 0 0 86 155 1 1
DIABLO CDH1 0 0 181 181 1 2
DIABLO BCL2L10 0 0 459 459 1 1
DIABLO MAPKAPK2 0 0 137 174 1 1
DIABLO CDK6 0 0 219 254 1 2
DIABLO NDUFA4 200 0 66 247 1 1
DIABLO DDX58 0 0 209 209 1 1
DIABLO MAVS 118 0 210 273 1 2
DIABLO H2AFX 0 0 247 246 1 1
DIABLO AVP 0 0 45 210 1 1
DIABLO IL1A 0 0 146 161 1 1
DIABLO TRADD 0 0 605 661 1 1
DIABLO ALK 0 0 144 179 1 2
DIABLO MIEF2 0 0 242 258 1 1
DIABLO CCDC125 0 0 112 175 1 1
DIABLO RNF31 0 540 377 701 1 1
DIABLO ANXA3 0 0 0 189 1 1
DIABLO COMMD1 0 0 323 342 1 1
DIABLO CUL1 0 0 134 177 1 1
DIABLO CASP7 0 600 738 892 1 1
DIABLO CD276 0 0 160 164 1 1
DIABLO OTULIN 0 0 207 207 1 1
DIABLO ALB 0 0 342 396 1 2
DIABLO CASP8 0 0 824 865 1 2
DIABLO CCL2 0 0 193 193 1 2
DIABLO ANXA8 0 0 330 330 1 1
DIABLO BIRC3 871 900 828 998 1 1
DIABLO TNFRSF10A 0 0 661 695 1 1
DIABLO SPOPL 0 0 66 154 1 1
DIABLO IL4 0 0 150 165 1 1
DIABLO ATP5A1 271 0 0 302 1 1
DIABLO SLC8B1 0 0 176 175 1 1
DIABLO PAWR 270 0 150 352 1 1
DIABLO PRTN3 0 0 81 163 1 1
DIABLO EGF 0 0 266 266 1 2
DIABLO PCSK1 0 0 556 564 1 1
DIABLO BFAR 0 0 114 235 1 1
DIABLO HK1 117 0 163 229 1 1
DIABLO ITPR1 0 0 265 265 1 2
DIABLO CASP9 213 900 939 995 1 2
DIABLO TRAF6 63 540 310 676 1 2
DIABLO ANXA13 0 0 0 248 1 1
DIABLO CLSPN 0 0 175 187 1 1
DIABLO CYCS 0 600 871 951 1 2
DIABLO CHEK2 0 0 216 216 1 1
DIABLO GADD45B 0 0 140 335 1 1
DIABLO TLR7 0 0 151 182 1 2
DIABLO IMMT 117 0 234 294 1 1
DIABLO MAPK9 0 0 265 270 1 2
DIABLO HSPB3 0 0 400 400 1 1
DIABLO HSP90B1 0 0 145 198 1 1
DIABLO C1QL1 0 0 53 153 1 1
DIABLO TATDN2 0 0 0 302 1 1
DIABLO RAD17 0 0 175 181 1 1
DIABLO MIEF1 0 0 211 211 1 1
DIABLO HSPA4 0 0 459 467 1 1
DIABLO ACVR1 0 0 0 181 1 1
DIABLO RCSD1 0 0 95 662 1 1
DIABLO PRF1 0 0 334 334 1 1
DIABLO GPX4 0 0 241 257 1 2
DIABLO INCENP 0 0 293 303 1 1
DIABLO OTUB1 0 0 134 157 1 1
DIABLO IFIH1 0 0 153 152 1 1
DIABLO HIST2H3PS2 0 0 183 183 1 1
DIABLO VPS33A 0 0 520 520 1 1
DIABLO MAP2K4 0 0 235 235 1 1
DIABLO MAPK8 0 0 395 397 1 2
DIABLO AURKB 0 0 244 249 1 1
DIABLO CAMTA1 0 0 0 155 1 1
DIABLO SKP2 0 0 134 155 1 2
DIABLO CASP10 0 0 517 629 1 1
DIABLO PARK7 0 0 112 228 1 2
DIABLO MOAP1 0 0 184 183 1 1
DIABLO NDUFS3 294 0 96 367 1 1
DIABLO NOL3 0 0 112 208 1 1
DIABLO TNFRSF12A 0 0 260 260 1 1
DIABLO MYCN 0 0 170 169 1 1
DIABLO UBA1 128 0 124 215 1 1
DIABLO RBCK1 0 0 265 265 1 1
DIABLO BRCA1 0 0 195 195 1 2
DIABLO CD80 0 0 232 231 1 2
DIABLO MAP2K1 0 0 271 271 1 1
DIABLO OPA1 117 0 184 290 1 2
DIABLO PPIF 0 0 561 570 1 1
DIABLO MFF 0 0 323 323 1 1
DIABLO C5 0 0 156 155 1 1
DIABLO PGAM5 118 0 457 515 1 1
DIABLO UBE2K 270 0 119 329 1 1
DIABLO PPP1R13B 0 0 81 162 1 1
DIABLO IGF1R 0 0 208 222 1 2
DIABLO USF1 0 0 53 153 1 1
DIABLO TAB2 0 0 285 284 1 2
DIABLO UBE2D1 0 0 170 169 1 1
DIABLO PPARGC1A 0 0 150 169 1 2
DIABLO TNFRSF6B 0 0 193 193 1 1
DIABLO MYC 0 0 413 412 1 2
DIABLO SLC25A12 117 0 0 151 1 1
DIABLO ELMOD2 0 0 435 438 1 1
DIABLO PARK2 0 0 212 212 1 1
DIABLO IFNA1 0 0 204 204 1 1
DIABLO IL18 0 0 218 218 1 2
DIABLO PIK3CA 0 0 143 161 1 2
DIABLO TPI1 0 0 411 431 1 1
DIABLO TOP1 0 0 209 209 1 1
DIABLO MICU1 97 0 155 204 1 1
DIABLO TAB1 118 0 379 429 1 1
DIABLO TRAF2 731 540 466 930 1 2
DIABLO TMBIM6 0 0 163 199 1 1
DIABLO CASP8AP2 0 0 124 274 1 1
DIABLO GLIPR2 0 0 45 179 1 2
DIABLO CLU 0 0 270 270 1 2
DIABLO STMN4 228 0 0 227 1 1
DIABLO NR4A1 111 0 134 197 1 2
DIABLO NGFRAP1 213 0 855 881 1 1
DIABLO JAK2 0 0 171 185 1 2
DIABLO TATDN1 0 0 0 150 1 1
DIABLO HDAC6 0 0 155 154 1 2
DIABLO APAF1 0 900 944 995 1 2
DIABLO RHBDL3 0 0 0 167 1 1
DIABLO VDAC2 0 0 425 473 1 1
DIABLO HTRA1 0 0 335 440 1 1
DIABLO STAT3 0 0 325 325 1 2
DIABLO MPDZ 0 0 0 188 1 1
DIABLO CHCHD6 117 0 142 236 1 1
DIABLO XRCC6 0 0 210 213 1 1
DIABLO ERN1 0 0 232 245 1 2
DIABLO PYCR1 0 0 502 502 1 1
DIABLO DYNLL1 179 0 74 207 1 1
DIABLO NDUFS1 108 0 90 157 1 1
DIABLO LAMP1 0 0 148 167 1 2
DIABLO NEDD8 0 0 205 271 1 2
DIABLO FADD 0 0 710 743 1 2
DIABLO HTT 0 0 167 167 1 2
DIABLO MYD88 0 0 218 218 1 2
DIABLO MAP3K13 0 0 206 206 1 1
DIABLO CFLAR 0 0 689 694 1 2
DIABLO EGFR 0 0 370 370 1 2
DIABLO CDK4 0 0 330 347 1 2
DIABLO PSTPIP1 0 0 62 206 1 1
DIABLO LRIG1 0 0 150 341 1 1
DIABLO TGM2 0 0 181 181 1 2
DIABLO TP53 0 0 652 659 1 2
DIABLO MDM2 0 0 459 459 1 2
DIABLO APBB1IP 0 0 161 161 1 1
DIABLO MAP3K7 118 0 218 293 1 2
DIABLO DDIT3 0 0 324 323 1 2
DIABLO SLC25A4 0 0 81 151 1 1
DIABLO CRADD 0 0 386 386 1 1
DIABLO TNFRSF11B 0 0 171 190 1 1
DIABLO LCP2 0 0 324 323 1 1
DIABLO ZBP1 0 0 170 169 1 1
DIABLO LMNA 0 0 181 181 1 2
DIABLO RAF1 0 0 211 224 1 2
DIABLO NCOR2 0 0 54 170 1 1
DIABLO HK2 0 0 171 171 1 2
DIABLO TRAF1 734 0 391 833 1 1
DIABLO C19orf70 461 0 46 484 1 1
DIABLO MYO5A 0 0 82 171 1 1
DIABLO PDCD5 0 0 97 246 1 1
DIABLO SGOL1 0 0 90 170 1 1
DIABLO RAD23A 128 0 54 164 1 1
DIABLO AP1B1 244 0 0 314 1 1
DIABLO MTOR 0 0 294 294 1 2
DIABLO NLRP1 0 0 152 151 1 1
DIABLO CXCR4 0 0 162 185 1 2
DIABLO TRAF4 0 0 207 207 1 1
DIABLO PIDD1 0 0 486 485 1 1
DIABLO OPA3 217 0 0 217 1 1
DIABLO CD40LG 0 0 243 242 1 1
DIABLO NOTCH1 0 0 204 204 1 2
DIABLO ACTR2 116 0 120 188 1 1
DIABLO STAT1 0 0 208 208 1 2
DIABLO ENDOG 97 0 804 841 1 1
DIABLO BCL2L2-PABPN1 0 0 602 602 1 1
DIABLO P4HTM 0 0 0 303 1 1
DIABLO DDX25 0 0 142 161 1 1
DIABLO GZMB 0 0 333 333 1 1
DIABLO TNFRSF1A 0 0 651 651 1 1
DIABLO GSPT1 0 0 205 228 1 1
DIABLO PIK3C3 0 0 158 180 1 2
DIABLO UCP2 0 0 135 175 1 2
DIABLO MAPRE1 0 0 54 263 1 1
DIABLO DCXR 0 0 158 157 1 1
DIABLO IL6 0 0 325 325 1 2
DIABLO CTRL 0 0 241 240 1 2
DIABLO SGSM2 0 0 0 303 1 1
DIABLO CXCL8 0 0 248 248 1 2
DIABLO SELENBP1 0 0 0 188 1 1
DIABLO GABPA 152 0 0 151 1 1
DIABLO RASGEF1A 0 0 66 219 1 1
DIABLO HIF1A 0 0 293 302 1 2
DIABLO MT1E 0 0 180 181 1 1
DIABLO TRAF5 0 540 384 704 1 1
DIABLO SIRT5 0 0 103 185 1 1
DIABLO PYGL 0 0 134 158 1 1
DIABLO BAG3 0 0 139 202 1 2
DIABLO IL1B 0 0 502 502 1 2
DIABLO XPO1 0 0 141 162 1 1
DIABLO PACS2 0 0 260 260 1 1
DIABLO TNFRSF1B 0 0 194 215 1 1
DIABLO CDK2 0 0 324 331 1 2
DIABLO CTNNB1 0 0 293 305 1 2
DIABLO HRAS 0 0 260 295 1 2
DIABLO MFN2 0 0 342 376 1 2
DIABLO APP 0 0 182 222 1 2
DIABLO GANAB 0 0 0 187 1 1
DIABLO BICD1 0 0 0 190 1 1
DIABLO NFKB1 0 0 203 222 1 2
DIABLO RNPS1 0 0 0 172 1 1
DIABLO RELA 0 0 366 366 1 2
DIABLO ENSG00000026036 0 0 193 193 1 1
DIABLO BCL2L1 0 900 758 978 1 2
DIABLO AMELX 0 0 0 293 1 1
DIABLO CASP6 0 0 556 556 1 1
DIABLO TAB3 0 0 233 232 1 1
DIABLO NPTN 0 0 487 487 1 1
DIABLO RAN 0 0 82 176 1 2
DIABLO P4HA2 0 0 0 303 1 1
DIABLO ZAP70 0 0 458 479 1 1
DIABLO GABARAPL2 0 0 156 155 1 2
DIABLO MAP2K7 0 0 330 330 1 1
DIABLO PLEKHG1 0 0 53 200 1 1
DIABLO ABL1 0 0 210 225 1 1
DIABLO TLR4 0 0 282 282 1 2
DIABLO GAPDH 0 0 455 462 1 2
DIABLO TNFRSF25 0 0 345 345 1 1
DIABLO APC 0 0 49 195 1 1
DIABLO GZMM 0 0 189 189 1 1
DIABLO IFNG 0 0 155 213 1 2
DIABLO BIRC2 900 900 987 999 1 1
DIABLO CREB1 0 0 261 261 1 2
DIABLO GSDMD 0 0 218 218 1 2
DIABLO USP9X 0 0 150 150 1 1
DIABLO UBE2D3 0 0 157 156 1 1
DIABLO KCNJ11 0 0 987 987 1 1
DIABLO RUNX1T1 0 0 45 191 1 1
DIABLO PSMA1 0 0 0 196 1 1
DIABLO PPID 0 0 279 282 1 1
DIABLO DIAPH1 0 0 357 357 1 1
DIABLO CUL7 270 0 0 270 1 1
DIABLO PLK1 0 0 206 206 1 2
DIABLO ANXA5 0 0 605 632 1 2
DIABLO CCNB1 0 0 261 261 1 1
DIABLO LAMTOR5 0 0 386 386 1 1
DIABLO MGMT 0 0 141 203 1 2
DIABLO HSPD1 653 0 138 693 1 1
DIABLO SLC25A6 0 0 150 241 1 1
DIABLO HOXA7 0 0 397 397 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in TAS
GO:0008635 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c involved_in IBA
GO:0008635 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c involved_in TAS
GO:0006915 Biological Process apoptotic process involved_in TAS
GO:0008625 Biological Process extrinsic apoptotic signaling pathway via death domain receptors involved_in TAS
GO:0097193 Biological Process intrinsic apoptotic signaling pathway involved_in TAS
GO:0008631 Biological Process intrinsic apoptotic signaling pathway in response to oxidative stress involved_in IBA
GO:0051402 Biological Process neuron apoptotic process involved_in IBA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in TAS
GO:0035631 Cellular Component CD40 receptor complex part_of ISS
GO:0009898 Cellular Component cytoplasmic side of plasma membrane located_in ISS
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005758 Cellular Component mitochondrial intermembrane space located_in TAS
GO:0005739 Cellular Component mitochondrion is_active_in IBA
GO:0005739 Cellular Component mitochondrion located_in IDA
Pathways
Name DB ID
Apoptosis Reactome R-HSA-109581
Intrinsic Pathway for Apoptosis Reactome R-HSA-109606
Release of apoptotic factors from the mitochondria Reactome R-HSA-111457
Formation of apoptosome Reactome R-HSA-111458
Cytochrome c-mediated apoptotic response Reactome R-HSA-111461
SMAC (DIABLO) binds to IAPs Reactome R-HSA-111463
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Reactome R-HSA-111464
SMAC, XIAP-regulated apoptotic response Reactome R-HSA-111469
Apoptotic factor-mediated response Reactome R-HSA-111471
Programmed Cell Death Reactome R-HSA-5357801
Regulation of the apoptosome activity Reactome R-HSA-9627069
Nanomaterial induced apoptosis (WP2507) WikiPathways WP2507_r123897
Complement system in neuronal development and plasticity (WP5090) WikiPathways WP5090_r118898
Apoptosis (WP254) WikiPathways WP254_r118382
TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001278303 1 mRNA transcript variant 6 NC_000012 Reference
NM_001278342 1 mRNA transcript variant 3 NC_000012 Reference
NM_001278302 1 mRNA transcript variant 5 NC_000012 Reference
NM_138930 3 mRNA transcript variant 2 NC_000012 Reference
NM_019887 6 mRNA transcript variant 1 NC_000012 Reference
NM_001371333 1 mRNA transcript variant 8 NC_000012 Reference
NM_001278304 2 mRNA transcript variant 7 NC_000012 Reference