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PSEN1

presenilin 1
General Information
Name presenilin 1
Alias
  • presenilin-1
  • familial Alzheimer Disease
Gene_family Peptidase family A22
organism Homo sapiens
entrez_id 5663
location 14q24.2
transcript_count 10
exon_count 13
Location
by NCBI GRCh38.p14
Summary
    Entrez Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
    Stringdb Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the compl [...]
    nextProt Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874, PubMed:28269784, PubMed:20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:9738936, PubMed:11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:25394380, PubMed:16959576). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
PSEN1 BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID CDH1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PSEN1 BioGRID VAMP3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DNAJC2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID S1PR4 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID KLRB1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DUOXA2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SERP2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID P2RY8 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID MFSD4A GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID TMPRSS11B GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID MGARP GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID POMK GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SPPL2B GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID VIPR1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SLC1A1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ST3GAL1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PTPRN2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID TAX1BP3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID NAAA GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID GPR45 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID RAMP3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID TSPAN5 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SYNGR1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID CDH12 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID CDH8 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ADGRE5 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID KRAS GeneID BioGRID Proximity Label-MS; Synthetic Lethality
PSEN1 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
PSEN1 BioGRID M GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID GSK3B GeneID BioGRID Affinity Capture-Western; Biochemical Activity
PSEN1 BioGRID APP GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
PSEN1 BioGRID EIF4G1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DHCR24 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PSEN1 BioGRID DDOST GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID CYP51A1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DNAJB12 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID TMCO1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DNAJB11 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID HACD3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID HSD17B12 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID RDH11 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID CNOT7 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ESYT1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID FAF2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID EMC1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DDX20 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ERLIN2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PSEN1 BioGRID TMED10 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PGRMC1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID TBL3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID EMC8 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DNAJA2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMD14 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID BCAP31 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID MLEC GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID EMC2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID BAG2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID FADS2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ZW10 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DEGS1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID BAG6 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID UBC GeneID BioGRID Affinity Capture-MS; Co-localization
PSEN1 BioGRID DNAJC7 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID CDKN2A GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ATP2A2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ARL1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID ARF4 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SLC10A6 GeneID BioGRID Two-hybrid
PSEN1 BioGRID TMEM43 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SRPRB GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID RHBDD2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SAR1A GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSENEN GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Two-hybrid
PSEN1 BioGRID TMEM33 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SSR4 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SSR3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SSR1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SOAT1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SLC1A5 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID SKP1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PSEN1 BioGRID SCD GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID RPN2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID RPL38 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID RANGAP1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMD2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PSEN1 BioGRID PSMC3 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMC2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMB5 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMB2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMB1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSEN1 BioGRID PSMA7 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMA6 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMA5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSEN1 BioGRID PSMA4 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSMA2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PSEN1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Two-hybrid
PSEN1 BioGRID CHMP1A GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PCBP2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID MLF1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID MAGEB2 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID FADS1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID STT3A GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID HSPB1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID HSPA5 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID DNAJA1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID GLB1 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID MCFD2 GeneID BioGRID Co-fractionation
PSEN1 BioGRID TOMM22 GeneID BioGRID Co-fractionation
PSEN1 BioGRID TMEM30A GeneID BioGRID Co-fractionation
PSEN1 BioGRID TXNRD2 GeneID BioGRID Co-fractionation
PSEN1 BioGRID PGD GeneID BioGRID Co-fractionation
PSEN1 BioGRID IVD GeneID BioGRID Co-fractionation
PSEN1 BioGRID CHCHD4 GeneID BioGRID Co-fractionation
PSEN1 BioGRID ALDH9A1 GeneID BioGRID Co-fractionation
PSEN1 BioGRID JUP GeneID BioGRID Reconstituted Complex
PSEN1 BioGRID CTNNB1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
PSEN1 BioGRID FKBP8 GeneID BioGRID Affinity Capture-Western; Two-hybrid
PSEN1 BioGRID NRAS GeneID BioGRID Proximity Label-MS
PSEN1 BioGRID HRAS GeneID BioGRID Proximity Label-MS
PSEN1 BioGRID BCL2 GeneID BioGRID Affinity Capture-Western; Co-localization; Two-hybrid
PSEN1 BioGRID NCSTN GeneID BioGRID Affinity Capture-Western; Co-fractionation; FRET
PSEN1 BioGRID NOTCH1 GeneID BioGRID Affinity Capture-Western; FRET
PSEN1 BioGRID DSP GeneID BioGRID Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PSEN1 BioGRID APH1A GeneID BioGRID Affinity Capture-Western; Co-fractionation
PSEN1 BioGRID MAPK9 GeneID BioGRID Biochemical Activity
PSEN1 BioGRID RYR2 GeneID BioGRID Reconstituted Complex
PSEN1 BioGRID CTNND1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSEN1 BioGRID CDH2 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID PTGER4 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID Ncstn GeneID BioGRID Affinity Capture-MS
PSEN1 BioGRID UNK GeneID BioGRID Affinity Capture-RNA
PSEN1 BioGRID GSAP GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western; Co-localization
PSEN1 BioGRID TGFBR1 GeneID BioGRID Affinity Capture-Western; Co-localization
PSEN1 BioGRID ETFA GeneID BioGRID Two-hybrid
PSEN1 BioGRID TDP2 GeneID BioGRID Two-hybrid
PSEN1 BioGRID PSEN2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
PSEN1 BioGRID APH1B GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID ITSN2 GeneID BioGRID Two-hybrid
PSEN1 BioGRID PDCD4 GeneID BioGRID Two-hybrid
PSEN1 BioGRID KANK2 GeneID BioGRID Two-hybrid
PSEN1 BioGRID EPB41L3 GeneID BioGRID Two-hybrid
PSEN1 BioGRID CDC37 GeneID BioGRID Affinity Capture-Western; Two-hybrid
PSEN1 BioGRID TUBA1B GeneID BioGRID Two-hybrid
PSEN1 BioGRID AP1M2 GeneID BioGRID Two-hybrid
PSEN1 BioGRID UMPS GeneID BioGRID Two-hybrid
PSEN1 BioGRID PRDX2 GeneID BioGRID Two-hybrid
PSEN1 BioGRID ST13 GeneID BioGRID Affinity Capture-Western; Two-hybrid
PSEN1 BioGRID SCN1A GeneID BioGRID Two-hybrid
PSEN1 BioGRID RHEB GeneID BioGRID Two-hybrid
PSEN1 BioGRID RAD23A GeneID BioGRID Two-hybrid
PSEN1 BioGRID RAB3A GeneID BioGRID Two-hybrid
PSEN1 BioGRID OXCT1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID NOS3 GeneID BioGRID Two-hybrid
PSEN1 BioGRID NDUFS8 GeneID BioGRID Co-fractionation
PSEN1 BioGRID HMGB1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID GCDH GeneID BioGRID Two-hybrid
PSEN1 BioGRID GAPDH GeneID BioGRID Two-hybrid
PSEN1 BioGRID FGF13 GeneID BioGRID Two-hybrid
PSEN1 BioGRID ENSA GeneID BioGRID Two-hybrid
PSEN1 BioGRID DTNA GeneID BioGRID Co-fractionation
PSEN1 BioGRID DHX9 GeneID BioGRID Co-fractionation
PSEN1 BioGRID CYP2C18 GeneID BioGRID Two-hybrid
PSEN1 BioGRID CYP2C8 GeneID BioGRID Two-hybrid
PSEN1 BioGRID RNF32 GeneID BioGRID Two-hybrid
PSEN1 BioGRID PRAM1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID EFHD1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID STAMBPL1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID RMDN3 GeneID BioGRID Two-hybrid
PSEN1 BioGRID FBXL12 GeneID BioGRID Two-hybrid
PSEN1 BioGRID ECSIT GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSEN1 BioGRID CFL1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID CDK5 GeneID BioGRID Two-hybrid
PSEN1 BioGRID APOE GeneID BioGRID Two-hybrid
PSEN1 BioGRID ACTN1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID IRAK2 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID HERPUD1 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID UBQLN1 GeneID BioGRID FRET; Reconstituted Complex; Two-hybrid
PSEN1 Protein CDH1 GeneID HPRD
PSEN1 Protein JUP GeneID HPRD
PSEN1 Protein PIK3R1 GeneID HPRD
PSEN1 Protein NOTCH4 GeneID HPRD
PSEN1 Protein MAPT GeneID HPRD
PSEN1 Protein BCL2 GeneID HPRD
PSEN1 Protein CASP1 GeneID HPRD
PSEN1 Protein GFAP GeneID HPRD
PSEN1 Protein CDK5 GeneID HPRD
PSEN1 Protein CTNNB1 GeneID HPRD
PSEN1 Protein CTNNA1 GeneID HPRD
PSEN1 Protein APP GeneID HPRD
PSEN1 Protein PSEN1 GeneID HPRD
PSEN1 Protein MTCH1 GeneID HPRD
PSEN1 Protein DOCK3 GeneID HPRD
PSEN1 Protein METTL2A GeneID HPRD
PSEN1 Protein CTNND2 GeneID HPRD
PSEN1 Protein HERPUD1 GeneID HPRD
PSEN1 Protein BACE1 GeneID HPRD
PSEN1 Protein YME1L1 GeneID HPRD
PSEN1 Protein PSENEN GeneID HPRD
PSEN1 Protein APH1B GeneID HPRD
PSEN1 Protein APH1A GeneID HPRD
PSEN1 Protein DLL1 GeneID HPRD
PSEN1 Protein FBXW7 GeneID HPRD
PSEN1 Protein RAB11A GeneID HPRD
PSEN1 Protein NCSTN GeneID HPRD
PSEN1 Protein UBQLN1 GeneID HPRD
PSEN1 Protein GSK3B GeneID HPRD
PSEN1 Protein KCNIP3 GeneID HPRD
PSEN1 Protein PKP4 GeneID HPRD
PSEN1 Protein ERN1 GeneID HPRD
PSEN1 Protein SCAF11 GeneID HPRD
PSEN1 Protein FLNB GeneID HPRD
PSEN1 Protein CASP4 GeneID HPRD
PSEN1 Protein APBA1 GeneID HPRD
PSEN1 Protein CIB1 GeneID HPRD
PSEN1 Protein TCF7L2 GeneID HPRD
PSEN1 Protein ICAM5 GeneID HPRD
PSEN1 Protein CASP8 GeneID HPRD
PSEN1 Protein CASP7 GeneID HPRD
PSEN1 Protein PRKACA GeneID HPRD
PSEN1 Protein CASP6 GeneID HPRD
PSEN1 Protein CTNND1 GeneID HPRD
PSEN1 Protein CASP3 GeneID HPRD
PSEN1 Protein EFNB2 GeneID HPRD
PSEN1 Protein NOTCH3 GeneID HPRD
PSEN1 Protein NOTCH2 GeneID HPRD
PSEN1 Protein BCL2L1 GeneID HPRD
PSEN1 Protein GDI1 GeneID HPRD
PSEN1 Protein FLNA GeneID HPRD
PSEN1 Protein NOTCH1 GeneID HPRD
PSEN1 Protein PRKCZ GeneID HPRD
PSEN1 BioGRID CIB1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID KCNIP4 GeneID BioGRID Two-hybrid
PSEN1 BioGRID FBXW7 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID KCNIP3 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID PKP4 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSEN1 BioGRID TCF7L2 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID MAPT GeneID BioGRID Co-fractionation
PSEN1 BioGRID GFAP GeneID BioGRID Reconstituted Complex; Two-hybrid
PSEN1 BioGRID ERN1 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID CTNNA1 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID BCL2L1 GeneID BioGRID Two-hybrid
PSEN1 BioGRID ICAM5 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSEN1 BioGRID FLNB GeneID BioGRID Reconstituted Complex; Two-hybrid
PSEN1 BioGRID Ctnnb1 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID CLSTN1 GeneID BioGRID Affinity Capture-Western
PSEN1 BioGRID YME1L1 GeneID BioGRID Two-hybrid
PSEN1 None None None BIND PEN-2 interacts with PS1.
PSEN1 None None None BIND APPswe interacts with PS-1delta-9.
PSEN1 Protein APH1A GeneID BIND APH-1A interacts with PSEN1.
PSEN1 Protein APP GeneID BIND PS1 interacts with APP.
PSEN1 Protein STX5 GeneID BIND The full-length PS1 holoprotein interacts with Syntaxin 5.
PSEN1 Protein APP GeneID BIND PS1 interacts with APP via the APP-C100 fragment.
PSEN1 Protein APP GeneID BIND PS1 interacts with APP695.
PSEN1 Protein APP GeneID BIND PS1 interacts with APP751.
PSEN1 Protein STX1A GeneID BIND PS1 interacts with syntaxin 1A.
PSEN1 Protein CASP7 GeneID BIND PS1 interacts with caspase 7. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 7.
PSEN1 Protein CASP3 GeneID BIND PS1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 3.
PSEN1 Protein NCSTN GeneID BIND PS1 interacts with Nicastrin.
PSEN1 Protein CASP4 GeneID BIND PS1 interacts with caspase 4. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 4.
PSEN1 Protein CASP1 GeneID BIND PS-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 1.
PSEN1 Protein CTNND2 GeneID BIND PS1 interacts with NPRAP
PSEN1 Protein CTNNB1 GeneID BIND PS1 interacts with beta-catenin.
StringDB
A B experiments database textmining combined score hadb nhadb
PSEN1 GCG 0 0 291 290 1 1
PSEN1 ATP12A 0 0 725 735 1 1
PSEN1 IL34 0 0 253 252 1 1
PSEN1 TFRC 0 0 267 267 1 1
PSEN1 SUPT5H 0 0 0 166 1 1
PSEN1 TXNIP 0 0 150 172 1 2
PSEN1 MMP8 0 0 82 174 1 1
PSEN1 RAB7A 0 0 359 395 1 2
PSEN1 REST 0 0 181 199 1 2
PSEN1 CDH5 0 0 154 175 1 1
PSEN1 BEST1 0 0 180 202 1 1
PSEN1 SCN4A 0 0 0 150 1 1
PSEN1 RHBDL1 0 0 0 448 1 1
PSEN1 CNR1 0 0 233 232 1 1
PSEN1 MERTK 0 0 167 189 1 1
PSEN1 GRIA3 0 0 166 192 1 1
PSEN1 MMP27 0 0 0 357 1 1
PSEN1 UVRAG 0 0 181 197 1 2
PSEN1 ITIH4 0 0 438 438 1 1
PSEN1 UBL7 0 0 0 202 1 1
PSEN1 DNAJC6 0 0 81 165 1 1
PSEN1 NBR1 0 0 180 317 1 2
PSEN1 TNF 0 0 507 559 1 2
PSEN1 MMP3 0 0 162 246 1 1
PSEN1 SYT10 0 0 61 179 1 1
PSEN1 PIK3R2 0 0 66 170 1 1
PSEN1 NR4A2 0 0 203 204 1 1
PSEN1 MMP25 0 0 0 358 1 1
PSEN1 MEF2C 0 0 257 272 1 1
PSEN1 VAPB 0 0 220 261 1 1
PSEN1 EAPP 0 0 152 167 1 1
PSEN1 CLSTN1 270 0 162 387 1 1
PSEN1 PDCD6IP 0 0 139 162 1 1
PSEN1 SYN2 0 0 171 213 1 1
PSEN1 NAIP 0 0 73 169 1 1
PSEN1 ATP13A2 0 0 392 415 1 1
PSEN1 FIS1 0 0 375 414 1 2
PSEN1 RCAN1 0 0 260 260 1 2
PSEN1 MS4A6A 0 0 492 491 1 1
PSEN1 LEO1 0 0 0 221 1 1
PSEN1 EEF2 0 0 125 154 1 2
PSEN1 ITCH 0 0 57 173 1 1
PSEN1 RBM8A 0 0 141 157 1 1
PSEN1 ZFYVE26 0 0 95 163 1 1
PSEN1 STT3B 0 0 487 562 1 1
PSEN1 ATXN7 0 0 140 169 1 1
PSEN1 MKRN3 0 0 0 451 1 1
PSEN1 ABCA2 0 0 125 163 1 1
PSEN1 RBFOX3 0 0 560 600 1 1
PSEN1 FMR1 47 0 235 245 1 1
PSEN1 CLN5 0 0 97 153 1 1
PSEN1 PACS1 0 0 112 301 1 1
PSEN1 PRB3 0 0 292 292 1 1
PSEN1 LIN28A 0 0 138 172 1 1
PSEN1 RBM20 0 0 295 295 1 1
PSEN1 EXOSC7 0 0 0 159 1 1
PSEN1 MESP2 0 0 386 395 1 1
PSEN1 BCL2 486 0 75 547 1 2
PSEN1 HPRT1 0 0 170 180 1 1
PSEN1 DCST1 0 0 0 346 1 1
PSEN1 NUMBL 0 0 160 254 1 1
PSEN1 SLC25A53 0 0 97 159 1 1
PSEN1 POU5F1 0 0 218 221 1 2
PSEN1 MAGI2 0 0 134 153 1 1
PSEN1 EGFL7 0 0 0 176 1 1
PSEN1 CANX 0 0 268 292 1 2
PSEN1 GRIA1 0 0 459 479 1 1
PSEN1 ABR 0 0 0 184 1 1
PSEN1 CAST 0 0 184 183 1 2
PSEN1 CAT 0 0 392 397 1 2
PSEN1 SPG11 0 0 181 184 1 1
PSEN1 SERPINE1 0 0 158 157 1 1
PSEN1 CDK1 0 0 165 197 1 2
PSEN1 REM1 0 0 0 165 1 1
PSEN1 GRP 0 0 103 199 1 2
PSEN1 MYO6 0 0 48 224 1 1
PSEN1 ADRB2 0 0 291 290 1 1
PSEN1 TTBK1 0 0 203 270 1 1
PSEN1 RPS6KB1 0 0 282 309 1 2
PSEN1 CC2D1A 0 0 0 282 1 1
PSEN1 UBL4A 0 0 0 162 1 1
PSEN1 LOX 0 0 181 181 1 2
PSEN1 SGK1 0 0 112 160 1 2
PSEN1 IRS1 0 0 334 335 1 2
PSEN1 GOLGA5 0 0 54 150 1 1
PSEN1 HSPA9 0 0 172 193 1 1
PSEN1 EPHB1 0 900 64 907 1 1
PSEN1 NTRK1 0 0 682 690 1 1
PSEN1 DVL2 0 0 74 154 1 2
PSEN1 STIM1 0 0 298 314 1 2
PSEN1 ABCG2 0 0 123 156 1 1
PSEN1 STON2 0 0 0 227 1 1
PSEN1 EPHA1 0 0 501 514 1 1
PSEN1 APEH 0 0 273 305 1 1
PSEN1 SREBF2 0 0 205 226 1 1
PSEN1 INS-IGF2 0 0 0 193 1 1
PSEN1 CDC37L1 0 0 90 175 1 1
PSEN1 KIF5B 0 0 108 205 1 1
PSEN1 CRIP2 0 0 0 188 1 1
PSEN1 CD47 0 0 217 217 1 2
PSEN1 EEA1 0 0 294 312 1 2
PSEN1 MCU 0 0 214 365 1 2
PSEN1 APOC1 0 0 254 254 1 1
PSEN1 EPHB3 0 900 0 903 1 1
PSEN1 GPN2 0 0 67 203 1 1
PSEN1 SORL1 0 0 710 735 1 1
PSEN1 PRSS50 0 0 290 295 1 1
PSEN1 ORAI2 0 0 167 172 1 1
PSEN1 SRC 0 0 294 320 1 2
PSEN1 FLT1 0 0 150 165 1 1
PSEN1 FBXW11 0 900 56 907 1 1
PSEN1 CIB1 192 0 262 378 1 1
PSEN1 METTL6 0 0 54 244 1 1
PSEN1 TUBB8 0 0 0 160 1 1
PSEN1 NPNT 0 0 0 176 1 1
PSEN1 TCF12 0 0 0 215 1 1
PSEN1 LRPAP1 0 0 123 157 1 1
PSEN1 GAD1 0 0 233 249 1 1
PSEN1 APOD 0 0 150 209 1 1
PSEN1 A2M 0 0 458 465 1 1
PSEN1 LRRC7 0 0 150 298 1 1
PSEN1 WWP2 0 0 0 159 1 1
PSEN1 EIF2AK3 0 800 302 854 1 2
PSEN1 GLRX 0 0 166 165 1 1
PSEN1 NRG1 0 0 357 357 1 2
PSEN1 BIN1 0 0 653 653 1 1
PSEN1 LRRK1 0 0 0 154 1 1
PSEN1 CD82 0 0 323 323 1 1
PSEN1 SEC13 0 0 708 721 1 1
PSEN1 SLC17A7 0 0 325 325 1 1
PSEN1 HMOX1 0 0 392 402 1 2
PSEN1 RBPJL 0 0 62 405 1 1
PSEN1 MMP12 0 0 107 162 1 1
PSEN1 COMMD3 0 0 0 181 1 1
PSEN1 EIF2S1 0 0 203 209 1 2
PSEN1 STX17 0 0 126 202 1 2
PSEN1 LYST 0 0 92 157 1 1
PSEN1 WASF1 0 0 119 179 1 1
PSEN1 TOMM20 0 0 203 243 1 2
PSEN1 NFATC2 0 0 151 161 1 1
PSEN1 TSC2 0 0 147 178 1 2
PSEN1 BNIP3L 0 0 171 181 1 2
PSEN1 C1QB 0 0 166 356 1 1
PSEN1 CLCN7 0 0 134 154 1 1
PSEN1 SPPL3 0 0 206 414 1 1
PSEN1 TGOLN2 0 0 148 187 1 1
PSEN1 APLP2 0 0 558 743 1 1
PSEN1 DHCR24 0 0 170 169 1 1
PSEN1 ZFYVE1 0 0 85 173 1 2
PSEN1 SCAND1 0 0 54 173 1 1
PSEN1 SNN 0 0 193 224 1 1
PSEN1 PPARG 0 0 425 439 1 2
PSEN1 UBE3A 0 0 181 249 1 1
PSEN1 CAPN1 0 0 240 256 1 2
PSEN1 TMED2 0 0 113 262 1 1
PSEN1 AKT1 0 0 556 597 1 2
PSEN1 UCKL1 0 0 46 163 1 1
PSEN1 BANP 0 0 57 153 1 1
PSEN1 ATF4 0 0 170 169 1 2
PSEN1 SYT4 0 0 73 189 1 1
PSEN1 PRKCG 0 0 117 150 1 1
PSEN1 CD4 0 0 481 481 1 2
PSEN1 CPE 309 0 47 328 1 1
PSEN1 ALS2 0 0 232 231 1 1
PSEN1 SYT14 0 0 49 168 1 1
PSEN1 SGK3 0 0 67 186 1 1
PSEN1 KLF4 0 0 218 235 1 2
PSEN1 ATF6 0 0 283 325 1 2
PSEN1 NEURL1B 0 0 0 211 1 1
PSEN1 FAM127A 0 0 63 205 1 1
PSEN1 GDI2 0 0 196 237 1 1
PSEN1 SPEN 0 0 75 371 1 1
PSEN1 PPP2R4 0 0 254 254 1 1
PSEN1 DLG1 0 0 123 189 1 1
PSEN1 XIAP 0 0 134 249 1 2
PSEN1 KCNJ6 0 0 94 332 1 1
PSEN1 CFH 0 0 231 230 1 1
PSEN1 DISC1 0 0 285 284 1 1
PSEN1 TCAP 0 0 145 203 1 1
PSEN1 SIRT4 0 0 292 292 1 1
PSEN1 BIRC5 0 0 60 157 1 2
PSEN1 ADAM2 0 0 210 224 1 1
PSEN1 ST6GAL1 0 0 123 199 1 1
PSEN1 GSK3A 0 0 308 500 1 1
PSEN1 RAB21 0 0 463 463 1 1
PSEN1 CXCL10 0 0 212 212 1 2
PSEN1 SPON1 0 0 241 240 1 1
PSEN1 ING5 0 0 134 164 1 1
PSEN1 YME1L1 192 0 536 631 1 1
PSEN1 PYCARD 0 0 134 168 1 2
PSEN1 VLDLR 0 0 425 438 1 1
PSEN1 CTSC 0 0 143 196 1 1
PSEN1 LOC102724488 0 0 59 178 1 1
PSEN1 NOTCH2NL 0 0 44 492 1 1
PSEN1 FBXO2 0 0 141 203 1 1
PSEN1 ERBB2 0 0 227 281 1 2
PSEN1 VTI1A 0 0 62 185 1 1
PSEN1 PRDX3 0 0 150 172 1 1
PSEN1 ENSG00000274276 0 0 134 152 1 1
PSEN1 KRAS 175 0 171 390 1 2
PSEN1 METTL2A 0 0 0 298 1 1
PSEN1 PADI2 0 0 76 154 1 1
PSEN1 DTX2 0 900 97 920 1 1
PSEN1 ADAM15 0 0 125 179 1 1
PSEN1 PDYN 0 0 97 662 1 1
PSEN1 SNRPB 0 0 57 203 1 1
PSEN1 PGA4 0 0 0 288 1 1
PSEN1 ASCL1 0 0 166 313 1 1
PSEN1 MMP24 0 0 125 278 1 1
PSEN1 TMEM11 0 0 342 346 1 1
PSEN1 PON1 0 0 182 181 1 1
PSEN1 AQP4 0 0 391 395 1 1
PSEN1 METTL2B 213 0 648 788 1 1
PSEN1 XAF1 0 0 47 263 1 1
PSEN1 SV2A 0 0 170 193 1 1
PSEN1 PHF1 0 0 556 585 1 1
PSEN1 APBA2 312 0 705 792 1 1
PSEN1 SIGMAR1 0 0 277 277 1 1
PSEN1 ENSG00000251246 0 0 66 175 1 1
PSEN1 LFNG 0 0 242 318 1 1
PSEN1 APH1A 974 900 989 999 1 1
PSEN1 HPS4 0 0 0 194 1 1
PSEN1 RPL23A 0 0 0 385 1 1
PSEN1 PLA2G4F 0 0 0 161 1 1
PSEN1 DUSP1 0 0 152 167 1 1
PSEN1 ERLIN2 289 0 126 428 1 1
PSEN1 NELL1 0 0 0 176 1 1
PSEN1 ATXN3 0 0 279 279 1 2
PSEN1 PTGER3 0 0 170 169 1 1
PSEN1 ELAVL4 0 0 143 151 1 1
PSEN1 KANK2 0 0 46 192 1 1
PSEN1 ABCB1 0 0 181 213 1 2
PSEN1 MAPT 270 0 849 910 1 2
PSEN1 BECN1 0 0 456 514 1 2
PSEN1 ABCC1 0 0 180 192 1 1
PSEN1 ALG3 0 0 386 386 1 1
PSEN1 LRP1 0 0 469 493 1 1
PSEN1 SPINT1 0 0 0 570 1 1
PSEN1 TLR6 0 0 157 156 1 1
PSEN1 PSENEN 974 900 989 999 1 1
PSEN1 IL2 0 0 205 205 1 1
PSEN1 GGA3 0 0 283 288 1 1
PSEN1 RAB20 0 0 0 161 1 1
PSEN1 ADAM29 0 0 0 286 1 1
PSEN1 CYBB 0 0 208 208 1 2
PSEN1 TREML2 0 0 218 218 1 1
PSEN1 ENSG00000268643 0 0 0 287 1 1
PSEN1 MRPL51 0 0 122 164 1 1
PSEN1 ACE 0 0 390 390 1 1
PSEN1 CTSS 0 0 125 364 1 1
PSEN1 LTBP3 0 0 72 202 1 1
PSEN1 ABCA7 0 0 663 675 1 1
PSEN1 IHH 0 0 45 272 1 1
PSEN1 REN 0 0 122 177 1 1
PSEN1 SLC1A1 0 0 242 262 1 1
PSEN1 IL13 0 0 167 167 1 2
PSEN1 SH3GL2 0 0 75 158 1 1
PSEN1 TMEM259 0 0 448 448 1 1
PSEN1 MSR1 0 0 166 181 1 1
PSEN1 ADAM21 0 0 108 388 1 1
PSEN1 PTGS2 0 0 395 397 1 2
PSEN1 MT-ND2 0 0 108 184 1 1
PSEN1 ERBB3 0 0 113 174 1 1
PSEN1 CASP3 213 0 558 651 1 2
PSEN1 DESI1 0 0 0 197 1 1
PSEN1 ZDHHC2 0 0 0 248 1 1
PSEN1 APCS 0 0 155 154 1 1
PSEN1 CTSZ 0 0 156 188 1 1
PSEN1 PLD2 0 0 208 306 1 1
PSEN1 HCRT 0 0 216 217 1 1
PSEN1 KLC1 0 0 181 243 1 1
PSEN1 NLRP3 0 0 409 408 1 2
PSEN1 ATG101 0 0 95 168 1 2
PSEN1 REL 0 0 154 153 1 2
PSEN1 CEBPZ 0 0 403 406 1 1
PSEN1 PLA2G6 0 0 233 249 1 1
PSEN1 WNT3 0 0 125 162 1 1
PSEN1 TXNRD2 128 0 69 159 1 1
PSEN1 CDH23 0 0 122 169 1 1
PSEN1 SLC30A4 0 0 151 150 1 1
PSEN1 FLOT2 270 0 144 383 1 1
PSEN1 ADAM28 0 0 0 196 1 1
PSEN1 WDR61 51 0 0 151 1 1
PSEN1 ATG16L1 0 0 139 161 1 2
PSEN1 SMPD1 0 0 180 197 1 1
PSEN1 APBB2 0 0 343 356 1 1
PSEN1 NTF3 0 0 235 235 1 1
PSEN1 EPHB2 0 900 288 927 1 2
PSEN1 MRPS18B 0 0 391 415 1 1
PSEN1 CDKN2A 47 0 183 192 1 2
PSEN1 PPP6C 0 0 66 421 1 1
PSEN1 ARRB2 0 0 155 173 1 1
PSEN1 RPS27A 0 0 0 151 1 1
PSEN1 GUSB 0 0 170 169 1 1
PSEN1 TARBP1 0 0 0 251 1 1
PSEN1 S100B 0 0 391 390 1 1
PSEN1 FAT4 0 0 0 212 1 1
PSEN1 TTR 0 0 391 390 1 1
PSEN1 GSK3B 766 800 716 992 1 2
PSEN1 GRIN3A 0 0 112 314 1 1
PSEN1 MRC1 0 0 218 218 1 1
PSEN1 AMPH 0 0 155 154 1 1
PSEN1 IGF2 0 0 213 213 1 1
PSEN1 DNER 270 900 431 961 1 1
PSEN1 CEPT1 0 0 0 186 1 1
PSEN1 ATP7B 0 0 92 212 1 1
PSEN1 CRB2 0 0 0 491 1 1
PSEN1 SCN2B 0 0 306 318 1 1
PSEN1 NTF4 0 0 193 193 1 1
PSEN1 GAD2 0 0 162 202 1 1
PSEN1 ATP5L 0 0 65 270 1 1
PSEN1 HPS1 0 0 0 463 1 1
PSEN1 CSRP3 0 0 137 250 1 1
PSEN1 CCL3 0 0 244 243 1 1
PSEN1 MARCKS 0 0 122 165 1 1
PSEN1 DMD 0 0 129 219 1 2
PSEN1 CPLX2 0 0 81 179 1 1
PSEN1 DLG4 0 0 654 672 1 2
PSEN1 OPRD1 0 0 359 359 1 1
PSEN1 PPP3R1 0 0 177 181 1 1
PSEN1 MATR3 0 0 108 158 1 1
PSEN1 DBH 0 0 203 203 1 1
PSEN1 IL10 0 0 391 390 1 2
PSEN1 SNAI1 0 0 162 168 1 1
PSEN1 CHL1 0 0 193 193 1 1
PSEN1 MMEL1 0 0 71 187 1 1
PSEN1 SNTG1 0 0 74 168 1 1
PSEN1 ACSL4 0 0 53 169 1 1
PSEN1 NUTF2 0 0 97 165 1 1
PSEN1 SLC2A14 0 0 278 298 1 1
PSEN1 FTL 47 0 122 187 1 1
PSEN1 GAPDHS 0 0 134 242 1 1
PSEN1 ZMYM5 0 0 209 209 1 1
PSEN1 C7orf34 0 0 194 250 1 1
PSEN1 MMP11 0 0 54 151 1 1
PSEN1 CD200 0 0 218 218 1 1
PSEN1 NME8 0 0 369 369 1 1
PSEN1 CDH8 229 0 122 313 1 1
PSEN1 TACSTD2 0 0 64 158 1 1
PSEN1 AMBRA1 0 0 166 175 1 2
PSEN1 SH3GL1 0 0 107 187 1 1
PSEN1 CNTN2 0 0 150 168 1 1
PSEN1 KAT5 0 0 252 310 1 1
PSEN1 CDX2 0 0 57 165 1 1
PSEN1 NGFR 0 900 322 940 1 1
PSEN1 MARK2 0 0 113 167 1 1
PSEN1 RCOR2 0 0 0 171 1 1
PSEN1 RGS2 0 0 60 291 1 1
PSEN1 LMNB1 0 0 108 169 1 1
PSEN1 NRD1 0 0 42 210 1 1
PSEN1 TBX6 0 0 261 278 1 1
PSEN1 UBQLN2 0 0 366 436 1 2
PSEN1 OPTN 0 0 298 298 1 2
PSEN1 HOMER1 0 0 292 311 1 1
PSEN1 NCL 0 0 125 173 1 2
PSEN1 ESR1 0 0 265 278 1 2
PSEN1 CALCOCO2 0 0 160 169 1 2
PSEN1 APBA3 0 0 147 236 1 1
PSEN1 PREP 0 0 97 153 1 1
PSEN1 PPT1 0 0 134 178 1 1
PSEN1 NEURL1 0 0 46 215 1 1
PSEN1 SYP 0 0 664 697 1 1
PSEN1 METTL8 0 0 0 234 1 1
PSEN1 SLC6A3 0 0 293 313 1 1
PSEN1 C1QA 0 0 125 174 1 1
PSEN1 ATP4A 0 0 294 418 1 1
PSEN1 MIB1 0 0 0 214 1 1
PSEN1 USP30 0 0 65 220 1 1
PSEN1 TSG101 0 0 143 185 1 2
PSEN1 ADI1 0 0 189 189 1 1
PSEN1 NECAB3 0 0 66 278 1 1
PSEN1 KCNN4 0 0 82 173 1 1
PSEN1 APBB3 0 0 212 212 1 1
PSEN1 WFDC1 0 0 207 207 1 1
PSEN1 RAB3A 0 0 160 181 1 1
PSEN1 TERT 0 0 113 155 1 2
PSEN1 AGFG1 0 0 180 266 1 1
PSEN1 UBC 273 0 125 422 1 2
PSEN1 RIN3 0 0 363 363 1 1
PSEN1 MAP1LC3B 0 0 284 300 1 2
PSEN1 MATN3 0 0 149 269 1 1
PSEN1 EFNA2 0 0 66 175 1 1
PSEN1 PCDH11X 0 0 243 261 1 1
PSEN1 IFT74 0 0 83 198 1 1
PSEN1 CA12 0 0 165 294 1 1
PSEN1 DST 0 0 0 187 1 2
PSEN1 PRKCA 0 0 150 173 1 1
PSEN1 MAP4 0 0 90 170 1 1
PSEN1 ULK1 0 0 184 183 1 2
PSEN1 STX7 0 0 96 158 1 2
PSEN1 CAMK2A 0 0 315 342 1 2
PSEN1 TBP 0 0 155 174 1 1
PSEN1 MT-CO1 0 0 124 329 1 1
PSEN1 HABP2 0 0 0 183 1 1
PSEN1 FN1 0 0 245 244 1 2
PSEN1 MMP13 0 0 66 209 1 2
PSEN1 CSNK2B 0 0 69 182 1 1
PSEN1 C3 0 0 261 261 1 2
PSEN1 HNRNPDL 0 0 91 233 1 1
PSEN1 FHL2 0 0 474 474 1 1
PSEN1 SRI 0 0 234 386 1 1
PSEN1 PARK7 0 0 502 540 1 2
PSEN1 EFNA5 0 0 112 219 1 1
PSEN1 UBD 0 0 46 162 1 1
PSEN1 SYNPO 0 0 172 173 1 1
PSEN1 SHANK1 0 0 152 156 1 1
PSEN1 CHI3L1 0 0 173 173 1 1
PSEN1 FXN 0 0 170 169 1 1
PSEN1 SUCO 0 0 66 211 1 1
PSEN1 SYT8 0 0 49 168 1 1
PSEN1 PPP3CC 0 0 125 297 1 1
PSEN1 SMAD4 0 0 453 453 1 2
PSEN1 S1PR2 0 0 225 225 1 1
PSEN1 NPY 0 0 243 242 1 1
PSEN1 DSP 271 0 52 331 1 1
PSEN1 FURIN 0 0 324 395 1 1
PSEN1 NFX1 0 800 0 800 1 1
PSEN1 PSMA6 0 0 48 156 1 1
PSEN1 LRRTM3 0 0 167 167 1 1
PSEN1 PPIF 0 0 316 331 1 1
PSEN1 SLC30A3 0 0 294 294 1 1
PSEN1 EID1 0 0 128 219 1 1
PSEN1 CH25H 0 0 145 173 1 1
PSEN1 UBBP4 0 0 0 165 1 1
PSEN1 UNK 270 0 0 371 1 1
PSEN1 MFF 0 0 180 179 1 1
PSEN1 MECP2 0 0 285 284 1 1
PSEN1 NFE2L2 0 0 323 323 1 2
PSEN1 UBE2K 0 0 134 157 1 1
PSEN1 ENSG00000272772 0 0 0 239 1 1
PSEN1 UCK1 0 0 0 154 1 1
PSEN1 DSG2 270 0 233 434 1 1
PSEN1 CTNND2 462 0 988 993 1 1
PSEN1 AKT2 0 0 108 191 1 2
PSEN1 VWCE 0 0 0 176 1 1
PSEN1 SDHC 0 0 137 163 1 1
PSEN1 IGF1R 0 0 246 266 1 2
PSEN1 KALRN 0 0 181 181 1 1
PSEN1 TNK1 0 0 192 192 1 1
PSEN1 TAB2 0 0 296 296 1 2
PSEN1 HLA-DRB5 0 0 374 374 1 1
PSEN1 CAPN3 0 0 62 160 1 1
PSEN1 ZNF274 0 900 0 902 1 1
PSEN1 MYC 0 0 378 382 1 2
PSEN1 APEX1 0 0 218 235 1 1
PSEN1 PPIG 0 0 99 190 1 1
PSEN1 WDR12 0 0 45 317 1 1
PSEN1 IL1R1 0 0 151 150 1 1
PSEN1 IL18 0 0 268 268 1 2
PSEN1 STEAP3 0 0 135 154 1 1
PSEN1 SLC6A4 0 0 204 227 1 1
PSEN1 NCSTN 979 900 989 999 1 1
PSEN1 SYT11 0 0 108 220 1 1
PSEN1 TOP3A 0 0 45 261 1 1
PSEN1 AJAP1 0 0 387 386 1 1
PSEN1 MMP17 0 0 0 358 1 1
PSEN1 EFNA4 0 0 62 153 1 1
PSEN1 AP4M1 0 0 103 199 1 1
PSEN1 SPTBN2 0 0 90 186 1 1
PSEN1 MAP2 0 0 395 488 1 2
PSEN1 APPL1 0 0 170 188 1 1
PSEN1 NPC1 0 0 283 319 1 2
PSEN1 DCTN4 0 0 90 249 1 1
PSEN1 PPP3CB 0 0 157 322 1 1
PSEN1 PIN1 0 0 145 197 1 1
PSEN1 TGM1 0 0 74 159 1 1
PSEN1 CAMKK2 0 0 124 154 1 2
PSEN1 RBFOX2 0 0 53 174 1 1
PSEN1 SLC26A5 0 0 94 209 1 1
PSEN1 HGS 0 0 73 162 1 2
PSEN1 LY86 0 0 70 178 1 1
PSEN1 ZFAND4 0 0 0 161 1 1
PSEN1 AGO2 0 0 96 171 1 2
PSEN1 ATP6V0D1 0 0 0 431 1 1
PSEN1 VDAC2 0 0 143 190 1 1
PSEN1 ADAM9 0 0 416 464 1 1
PSEN1 SNX12 0 0 138 165 1 1
PSEN1 STAT3 0 0 324 323 1 2
PSEN1 ERN1 270 800 270 887 1 2
PSEN1 EXT1 0 0 48 151 1 1
PSEN1 RAB4A 0 0 202 225 1 1
PSEN1 MYD88 0 0 173 197 1 2
PSEN1 CCS 0 0 96 158 1 2
PSEN1 DHH 0 0 0 269 1 1
PSEN1 CCRN4L 0 0 0 237 1 1
PSEN1 FBLN2 0 0 0 176 1 1
PSEN1 TUBA4A 0 0 108 151 1 1
PSEN1 STX5 0 0 671 671 1 1
PSEN1 SCN10A 0 0 339 344 1 1
PSEN1 CFTR 0 0 155 164 1 2
PSEN1 ZNF143 0 0 0 201 1 1
PSEN1 DDIT3 0 0 261 267 1 2
PSEN1 PRKACG 0 800 0 808 1 1
PSEN1 ORAI1 0 0 117 172 1 1
PSEN1 PLP1 0 0 173 173 1 1
PSEN1 LMNA 0 0 207 207 1 2
PSEN1 SNAP23 0 0 123 166 1 1
PSEN1 PRIMA1 0 0 457 457 1 1
PSEN1 CSF3 0 0 181 181 1 1
PSEN1 NRXN3 0 0 161 161 1 1
PSEN1 HK2 0 0 74 156 1 2
PSEN1 PRH2 0 0 242 241 1 1
PSEN1 CC2D1B 0 0 0 258 1 1
PSEN1 RPL13A 0 0 82 177 1 1
PSEN1 SYT7 0 0 76 192 1 1
PSEN1 NLRP1 0 0 188 188 1 1
PSEN1 CALM1 0 0 163 215 1 1
PSEN1 C4A 0 0 235 235 1 1
PSEN1 SORT1 0 900 325 932 1 1
PSEN1 POTEF 0 0 190 240 1 1
PSEN1 PSEN2 486 800 990 899 1 1
PSEN1 FGF13 0 0 180 179 1 1
PSEN1 PTGS1 0 0 173 173 1 1
PSEN1 SEC61A1 0 0 103 234 1 1
PSEN1 ENSG00000278882 0 0 0 491 1 1
PSEN1 TM2D3 0 0 179 200 1 1
PSEN1 SLC30A6 0 0 170 169 1 1
PSEN1 NOTCH1 676 900 980 999 1 2
PSEN1 EGFL8 0 0 67 198 1 1
PSEN1 ACTR2 0 0 68 210 1 1
PSEN1 RARS2 0 0 0 157 1 1
PSEN1 SHMT1 0 0 87 512 1 1
PSEN1 TNFRSF1A 0 0 202 202 1 1
PSEN1 CHMP2B 0 0 518 531 1 2
PSEN1 IL6 0 0 517 521 1 2
PSEN1 SCAF11 213 0 0 268 1 1
PSEN1 NCR3 0 0 0 207 1 1
PSEN1 SYTL5 0 0 0 161 1 1
PSEN1 SIRT5 0 0 293 321 1 1
PSEN1 KCNIP2 0 0 62 318 1 1
PSEN1 HIF1A 0 0 556 561 1 2
PSEN1 EDN1 0 0 134 271 1 1
PSEN1 PRKCB 0 0 142 153 1 2
PSEN1 TRPM7 0 0 385 384 1 1
PSEN1 IL1B 0 0 600 600 1 2
PSEN1 MATN4 0 0 0 339 1 1
PSEN1 NAE1 0 0 155 301 1 1
PSEN1 DLG2 0 0 194 216 1 1
PSEN1 SP1 0 0 167 266 1 2
PSEN1 ERBB2IP 0 0 126 166 1 1
PSEN1 HMGN1 0 0 54 218 1 1
PSEN1 ACSL3 0 0 0 447 1 1
PSEN1 PLA2G4A 0 0 156 155 1 1
PSEN1 RHO 0 0 141 159 1 2
PSEN1 HBG2 0 0 0 189 1 1
PSEN1 MS4A4A 0 0 370 370 1 1
PSEN1 CYP4B1 0 0 294 306 1 1
PSEN1 PACS2 0 0 204 236 1 1
PSEN1 ASPA 0 0 66 272 1 1
PSEN1 CDK2 0 0 142 202 1 2
PSEN1 MAP1LC3A 0 0 137 225 1 2
PSEN1 CLSTN3 0 0 170 217 1 1
PSEN1 SCN1A 0 0 307 312 1 1
PSEN1 SHMT2 0 0 0 390 1 1
PSEN1 MAPK8IP1 0 0 243 290 1 1
PSEN1 DNMT3B 0 0 181 181 1 1
PSEN1 DNMT3A 0 0 161 212 1 2
PSEN1 C1R 0 0 392 398 1 1
PSEN1 KCNIP4 192 0 389 485 1 1
PSEN1 TUBB4A 0 0 113 160 1 1
PSEN1 BCL2L1 192 0 453 546 1 2
PSEN1 SCUBE1 0 0 0 176 1 1
PSEN1 PIK3R4 0 0 173 173 1 2
PSEN1 SLC9A1 0 0 0 535 1 1
PSEN1 DPP3 0 0 66 589 1 1
PSEN1 TSNARE1 0 0 57 221 1 1
PSEN1 CLEC7A 0 0 204 218 1 1
PSEN1 ITPR2 0 800 212 877 1 1
PSEN1 RAP1A 0 0 0 157 1 1
PSEN1 GABARAPL2 0 0 174 186 1 2
PSEN1 SLC18A3 0 0 141 163 1 1
PSEN1 JAG2 0 0 377 627 1 1
PSEN1 GPS1 0 0 231 309 1 1
PSEN1 APOA1 0 0 284 284 1 1
PSEN1 SNW1 0 0 140 157 1 1
PSEN1 NOS2 0 0 252 282 1 2
PSEN1 KIF1A 0 0 134 157 1 1
PSEN1 ATP5L2 0 0 0 190 1 1
PSEN1 SMAD2 0 0 164 163 1 2
PSEN1 TLR4 0 0 344 343 1 2
PSEN1 AGFG2 0 0 67 165 1 1
PSEN1 GSTO1 0 0 325 325 1 1
PSEN1 TSPAN12 0 0 165 165 1 1
PSEN1 PDDC1 0 0 91 487 1 1
PSEN1 ATG14 0 0 151 169 1 2
PSEN1 BAP1 0 0 307 307 1 1
PSEN1 BIRC2 0 0 82 238 1 1
PSEN1 IFNG 0 0 260 310 1 2
PSEN1 NDN 0 0 82 291 1 1
PSEN1 UBQLN4 0 0 57 402 1 1
PSEN1 CCL5 0 0 210 210 1 2
PSEN1 SDF4 0 0 650 656 1 1
PSEN1 PLCG2 0 0 123 192 1 1
PSEN1 SYT12 0 0 87 201 1 1
PSEN1 PRKACA 213 800 0 842 1 1
PSEN1 CALB2 0 0 283 295 1 1
PSEN1 NOTCH4 213 900 323 950 1 1
PSEN1 PSMB1 270 0 59 400 1 1
PSEN1 CLIP1 0 0 74 274 1 1
PSEN1 POU3F2 0 0 166 165 1 1
PSEN1 PSMA1 0 0 96 160 1 1
PSEN1 RER1 0 0 202 237 1 1
PSEN1 DTNA 271 0 0 271 1 1
PSEN1 EPO 0 0 166 165 1 2
PSEN1 ETFA 192 0 67 213 1 1
PSEN1 GSTO2 0 0 326 325 1 1
PSEN1 RELN 0 0 370 370 1 1
PSEN1 NAV1 0 0 414 414 1 1
PSEN1 PLK1 129 0 89 201 1 2
PSEN1 PTGER1 0 0 298 298 1 1
PSEN1 SIAH1 0 0 161 213 1 1
PSEN1 GALK1 0 0 0 173 1 1
PSEN1 RYR3 0 800 330 876 1 1
PSEN1 FLNC 0 0 444 558 1 1
PSEN1 GRIA4 0 0 147 191 1 1
PSEN1 STARD9 0 0 0 227 1 1
PSEN1 LMAN1 0 0 432 432 1 1
PSEN1 GRIA2 0 0 285 313 1 1
PSEN1 CCNB1 0 0 141 191 1 1
PSEN1 ANXA5 0 0 202 219 1 2
PSEN1 HSPD1 0 0 134 156 1 1
PSEN1 SNED1 0 0 0 176 1 1
PSEN1 HES1 0 0 170 221 1 2
PSEN1 TRPC1 0 0 185 249 1 1
PSEN1 VSNL1 0 0 240 239 1 1
PSEN1 RASD1 0 0 107 152 1 1
PSEN1 GRIN2D 0 0 102 197 1 1
PSEN1 CNR2 0 0 134 188 1 1
PSEN1 TFAM 0 0 262 297 1 2
PSEN1 MMP2 0 0 215 242 1 2
PSEN1 AGRN 0 0 161 203 1 1
PSEN1 TCIRG1 0 0 73 223 1 1
PSEN1 IGFBP3 0 0 107 196 1 2
PSEN1 DLL1 213 0 699 841 1 1
PSEN1 CASS4 0 0 392 392 1 1
PSEN1 CD8A 0 0 284 284 1 1
PSEN1 PEMT 0 0 94 308 1 1
PSEN1 CALR 0 0 214 479 1 1
PSEN1 CCR5 0 0 154 153 1 1
PSEN1 HDLBP 0 0 123 168 1 1
PSEN1 P2RY12 0 0 235 235 1 1
PSEN1 ALLC 0 0 167 202 1 1
PSEN1 DTX4 0 900 95 920 1 1
PSEN1 PRDX1 0 0 454 454 1 1
PSEN1 CSNK1A1 0 0 278 325 1 1
PSEN1 SHH 0 0 214 401 1 2
PSEN1 ANK1 0 0 209 224 1 1
PSEN1 SNX27 0 0 474 478 1 1
PSEN1 GRN 0 0 602 608 1 1
PSEN1 VCP 0 0 459 468 1 2
PSEN1 LCK 0 0 112 162 1 1
PSEN1 CAPN2 0 0 150 209 1 2
PSEN1 LAMP2 0 0 293 329 1 2
PSEN1 ITPR3 0 800 424 910 1 1
PSEN1 RHOT1 0 0 124 266 1 1
PSEN1 NBPF12 0 0 358 358 1 1
PSEN1 DVL3 0 0 120 176 1 1
PSEN1 ZDHHC16 0 0 0 151 1 1
PSEN1 SNX1 0 0 115 232 1 1
PSEN1 NPTXR 0 0 171 171 1 1
PSEN1 DLL4 0 0 294 546 1 1
PSEN1 HNRNPA1 0 0 139 182 1 1
PSEN1 GRIN2C 0 0 108 227 1 1
PSEN1 CALB1 0 0 284 298 1 1
PSEN1 SERPINA1 0 0 181 181 1 2
PSEN1 PHF13 0 0 310 325 1 1
PSEN1 MAML1 0 0 261 266 1 1
PSEN1 KL 0 0 204 204 1 2
PSEN1 CAV1 0 0 277 277 1 2
PSEN1 HLA-DRB1 0 0 268 268 1 1
PSEN1 HSPA1A 0 0 142 195 1 1
PSEN1 USP35 0 0 0 211 1 1
PSEN1 PLS1 0 0 60 164 1 1
PSEN1 NPC2 0 0 233 232 1 1
PSEN1 SNAP29 0 0 120 158 1 2
PSEN1 CD74 0 0 82 176 1 1
PSEN1 SLC25A27 0 0 142 336 1 1
PSEN1 SNCA 0 0 688 708 1 2
PSEN1 PLAT 0 0 156 163 1 1
PSEN1 CASP1 213 0 391 518 1 2
PSEN1 RTN4R 0 0 140 181 1 1
PSEN1 DTX1 0 900 304 938 1 1
PSEN1 GRASP 0 0 95 154 1 1
PSEN1 GLI3 0 0 160 179 1 1
PSEN1 F12 0 0 0 183 1 1
PSEN1 GLO1 0 0 82 219 1 1
PSEN1 ANGPT1 0 0 103 337 1 1
PSEN1 SETSIP 0 0 0 203 1 1
PSEN1 CSNK1E 0 0 0 154 1 1
PSEN1 SIRT3 0 0 369 369 1 2
PSEN1 SYT6 0 0 48 167 1 1
PSEN1 KEAP1 0 0 210 245 1 2
PSEN1 STUB1 0 0 218 235 1 2
PSEN1 DNMT1 0 0 260 260 1 2
PSEN1 GLP1R 0 0 261 261 1 1
PSEN1 CD40 0 0 181 181 1 2
PSEN1 SPG7 0 0 155 205 1 1
PSEN1 FPR2 0 0 233 232 1 1
PSEN1 ENSG00000258555 0 0 233 232 1 1
PSEN1 NEFH 0 0 253 271 1 1
PSEN1 ACTB 0 0 558 585 1 2
PSEN1 INS 0 0 519 519 1 2
PSEN1 CLDN5 0 0 258 258 1 1
PSEN1 GAS6 0 0 217 217 1 1
PSEN1 PTCH2 0 0 0 335 1 1
PSEN1 COX4I1 0 0 195 195 1 1
PSEN1 HTRA2 192 0 698 764 1 1
PSEN1 NEUROD1 0 0 246 245 1 1
PSEN1 SFI1 0 0 95 252 1 1
PSEN1 BACE2 0 0 609 648 1 1
PSEN1 FBXW7 270 0 255 626 1 2
PSEN1 HPGDS 0 0 211 211 1 1
PSEN1 CALHM1 0 0 381 393 1 1
PSEN1 ITGB3BP 0 900 0 900 1 1
PSEN1 KIF5A 0 0 141 194 1 1
PSEN1 TFEB 0 0 450 454 1 2
PSEN1 GABARAPL1 0 0 180 191 1 2
PSEN1 ADORA2A 0 0 212 212 1 1
PSEN1 ABCG4 0 0 73 150 1 1
PSEN1 LOXL4 0 0 150 219 1 1
PSEN1 SIRT7 0 0 291 290 1 2
PSEN1 AKAP9 0 0 183 204 1 1
PSEN1 TAS2R38 0 0 166 165 1 1
PSEN1 ESR2 0 0 203 217 1 1
PSEN1 HBE1 0 0 0 303 1 1
PSEN1 LTBP2 0 0 69 200 1 1
PSEN1 TARDBP 0 0 519 552 1 2
PSEN1 RCN2 0 0 0 167 1 1
PSEN1 RBM14 0 0 0 335 1 1
PSEN1 PLA2G1B 0 0 161 161 1 1
PSEN1 KDM1A 0 0 96 258 1 2
PSEN1 TOMM40 0 0 469 479 1 1
PSEN1 TPM1 0 0 122 154 1 1
PSEN1 ZDHHC20 0 0 0 248 1 1
PSEN1 RHOA 0 0 261 301 1 2
PSEN1 PARP1 0 0 171 171 1 2
PSEN1 EPCAM 0 0 100 191 1 2
PSEN1 GSR 0 0 261 261 1 1
PSEN1 INSR 0 0 157 179 1 1
PSEN1 HSPA8 0 0 284 356 1 2
PSEN1 JUP 462 0 60 535 1 1
PSEN1 NKRF 0 0 138 185 1 1
PSEN1 SPPL2A 0 0 241 353 1 1
PSEN1 PLG 0 0 215 216 1 1
PSEN1 RYR1 0 0 155 254 1 2
PSEN1 RMDN1 0 0 0 205 1 1
PSEN1 CERS2 0 0 71 163 1 1
PSEN1 SYT9 0 0 66 183 1 1
PSEN1 MATN1 0 0 0 176 1 1
PSEN1 BLMH 0 0 154 243 1 1
PSEN1 C4B 0 0 232 231 1 1
PSEN1 CP 0 0 167 167 1 1
PSEN1 DNM2 0 0 112 225 1 1
PSEN1 IL1A 0 0 322 321 1 1
PSEN1 CCL4 0 0 194 194 1 1
PSEN1 HTR1A 0 0 137 163 1 1
PSEN1 SPAST 0 0 210 232 1 1
PSEN1 SYTL4 0 0 0 161 1 1
PSEN1 BDKRB2 0 0 68 177 1 1
PSEN1 DCTN1 0 0 211 229 1 1
PSEN1 CUL5 0 0 0 303 1 1
PSEN1 IAPP 0 0 345 353 1 2
PSEN1 ABCA1 0 0 459 479 1 2
PSEN1 BSG 270 0 321 525 1 1
PSEN1 DPP4 0 0 180 377 1 1
PSEN1 DEGS1 47 0 150 155 1 1
PSEN1 DLL3 0 0 321 416 1 1
PSEN1 VPS54 0 0 62 192 1 1
PSEN1 GXYLT1 0 0 0 176 1 1
PSEN1 LGALS4 0 0 283 321 1 1
PSEN1 PPP2R5A 0 0 50 157 1 1
PSEN1 UCHL3 0 0 294 318 1 1
PSEN1 HSPG2 0 0 100 166 1 1
PSEN1 ITGB1 0 0 113 181 1 1
PSEN1 FAP 0 0 74 297 1 2
PSEN1 FLOT1 0 0 299 352 1 1
PSEN1 HERPUD1 486 0 269 608 1 1
PSEN1 COMMD1 0 0 0 154 1 1
PSEN1 LEPR 0 0 182 181 1 1
PSEN1 REEP5 0 0 70 155 1 1
PSEN1 CASP8 213 0 267 411 1 2
PSEN1 SORCS3 0 0 138 176 1 1
PSEN1 KNG1 0 0 208 208 1 1
PSEN1 FBLN1 0 0 42 177 1 1
PSEN1 MITD1 0 0 0 169 1 1
PSEN1 DBN1 0 0 358 362 1 1
PSEN1 HPS3 0 0 0 173 1 1
PSEN1 VAMP2 0 0 255 271 1 1
PSEN1 PPEF1 0 0 0 265 1 1
PSEN1 TUBB3 0 0 135 262 1 1
PSEN1 CTNNA3 0 0 335 335 1 1
PSEN1 CNTF 0 0 181 181 1 1
PSEN1 UBQLN3 0 0 91 191 1 1
PSEN1 SLC30A1 0 0 125 156 1 1
PSEN1 SVEP1 0 0 0 176 1 1
PSEN1 NOTCH3 213 900 421 973 1 1
PSEN1 IL17A 0 0 234 234 1 2
PSEN1 NRXN2 0 0 161 161 1 1
PSEN1 CASP9 0 0 253 269 1 2
PSEN1 ITPR1 0 800 820 983 1 2
PSEN1 NANOG 0 0 167 167 1 2
PSEN1 HK1 0 0 89 170 1 1
PSEN1 ITGA8 0 0 0 188 1 1
PSEN1 POMC 0 0 180 210 1 1
PSEN1 NMRK2 0 0 0 153 1 1
PSEN1 ALDH1L1 0 0 141 162 1 1
PSEN1 ZNF592 0 0 0 158 1 1
PSEN1 OGG1 0 0 166 238 1 1
PSEN1 MAPK9 270 0 265 466 1 2
PSEN1 RPTOR 0 0 170 227 1 2
PSEN1 NES 0 0 339 339 1 2
PSEN1 ATP2C2 0 0 0 157 1 1
PSEN1 FBXO7 0 0 212 238 1 1
PSEN1 ZPR1 0 0 0 256 1 1
PSEN1 TRIP13 0 0 0 160 1 1
PSEN1 SPC24 0 0 0 157 1 1
PSEN1 CX3CR1 0 0 456 456 1 1
PSEN1 PPIB 0 0 332 332 1 1
PSEN1 SNRPN 0 0 71 164 1 1
PSEN1 HES5 0 0 325 325 1 1
PSEN1 TRIP4 0 0 122 273 1 1
PSEN1 RCN3 0 0 66 152 1 1
PSEN1 TSPAN16 0 0 378 378 1 1
PSEN1 PTGER4 270 0 208 397 1 1
PSEN1 UBQLNL 0 0 112 218 1 1
PSEN1 NR3C1 0 0 181 239 1 1
PSEN1 MT-ND6 0 0 134 157 1 1
PSEN1 MTHFD1L 0 0 181 185 1 1
PSEN1 STIM2 0 0 391 404 1 1
PSEN1 TNS1 0 0 73 158 1 1
PSEN1 NFIC 0 900 66 912 1 1
PSEN1 HIST2H3PS2 0 0 234 247 1 1
PSEN1 HSPA6 0 0 47 157 1 1
PSEN1 ATP6V0A2 0 0 0 211 1 1
PSEN1 TBXA2R 0 0 53 225 1 1
PSEN1 ENO2 0 0 324 333 1 1
PSEN1 LTBP1 0 0 0 176 1 1
PSEN1 HORMAD2 0 0 0 207 1 1
PSEN1 ARG1 0 0 262 262 1 2
PSEN1 GCLC 0 0 134 255 1 1
PSEN1 GNPTAB 0 900 0 900 1 1
PSEN1 TNNT2 0 0 107 162 1 1
PSEN1 PTCH1 0 0 108 381 1 1
PSEN1 TC2N 0 0 0 161 1 1
PSEN1 ATN1 0 0 100 157 1 1
PSEN1 TNFAIP6 0 0 0 207 1 1
PSEN1 CD2AP 0 0 560 568 1 1
PSEN1 PLEKHA4 270 0 0 270 1 1
PSEN1 SH3GL3 0 0 145 222 1 1
PSEN1 OLFML3 0 0 138 168 1 1
PSEN1 BCL2A1 0 0 117 172 1 1
PSEN1 ENSG00000196136 0 0 395 394 1 1
PSEN1 PPEF2 0 0 0 265 1 1
PSEN1 BCAP31 47 0 182 193 1 1
PSEN1 FGF2 0 0 325 325 1 2
PSEN1 EXOC3L2 0 0 343 343 1 1
PSEN1 SEC61A2 0 0 0 171 1 1
PSEN1 PPP2R5C 0 0 0 202 1 1
PSEN1 APBA1 678 0 469 824 1 1
PSEN1 EPHB4 0 900 82 911 1 1
PSEN1 WDR45 0 0 181 195 1 2
PSEN1 LIMD2 0 0 0 164 1 1
PSEN1 EFNA3 0 0 66 175 1 1
PSEN1 NEDD4L 0 0 48 211 1 1
PSEN1 CSF1R 0 0 336 351 1 1
PSEN1 APOB 0 0 194 194 1 2
PSEN1 IGF1 0 0 451 457 1 2
PSEN1 MAPK1 0 0 233 283 1 2
PSEN1 DPP10 0 0 0 157 1 1
PSEN1 LTBP4 0 0 0 176 1 1
PSEN1 CELF1 0 0 292 300 1 1
PSEN1 YBX1 0 900 0 902 1 1
PSEN1 EPHB6 0 900 0 902 1 1
PSEN1 SNAP25 0 0 359 359 1 1
PSEN1 EYA3 0 0 0 153 1 1
PSEN1 CASP2 0 0 165 216 1 1
PSEN1 DUSP26 0 0 164 178 1 1
PSEN1 SYT16 0 0 53 172 1 1
PSEN1 BDNF 0 0 662 677 1 2
PSEN1 GSAP 270 0 710 804 1 1
PSEN1 CD44 0 0 283 291 1 2
PSEN1 HERC2 0 0 0 154 1 1
PSEN1 COA8 0 0 171 233 1 1
PSEN1 PLA2G4D 0 0 0 161 1 1
PSEN1 APH1B 462 900 822 996 1 1
PSEN1 SMPD2 0 0 166 165 1 1
PSEN1 CBSL 0 0 134 152 1 1
PSEN1 EFNA1 0 0 82 203 1 1
PSEN1 GBA 0 0 386 403 1 1
PSEN1 ATP2A2 47 0 81 260 1 1
PSEN1 LDLR 0 0 391 405 1 2
PSEN1 DFFA 0 0 120 175 1 1
PSEN1 CD38 0 0 134 170 1 2
PSEN1 PPP2R5E 0 0 0 192 1 1
PSEN1 ANXA7 0 0 90 182 1 1
PSEN1 RHEB 0 0 123 172 1 2
PSEN1 SMN2 0 0 182 224 1 1
PSEN1 RETNLB 0 0 170 169 1 1
PSEN1 ENSG00000264813 0 0 370 370 1 1
PSEN1 GRIK5 0 0 96 157 1 1
PSEN1 LRP6 0 0 244 288 1 1
PSEN1 LCP1 0 0 45 151 1 1
PSEN1 TXN 0 0 231 230 1 1
PSEN1 ATP11A 0 0 0 171 1 1
PSEN1 IDE 0 0 752 814 1 1
PSEN1 PTK2B 0 0 358 373 1 1
PSEN1 UBB 0 0 75 195 1 1
PSEN1 PECAM1 0 0 162 161 1 1
PSEN1 GIP 0 0 240 239 1 1
PSEN1 RIC8B 0 0 125 165 1 1
PSEN1 HIST2H2BE 0 0 127 174 1 1
PSEN1 PPP2CA 0 0 156 427 1 1
PSEN1 OLIG2 0 0 181 181 1 1
PSEN1 YWHAQ 0 0 561 582 1 1
PSEN1 HEY1 0 0 292 304 1 1
PSEN1 BAD 0 0 75 174 1 2
PSEN1 HMGCR 0 0 180 179 1 1
PSEN1 MTHFR 0 0 310 320 1 1
PSEN1 ADRA2C 0 0 290 290 1 1
PSEN1 IRAK2 270 0 0 295 1 1
PSEN1 FAU 0 0 0 158 1 2
PSEN1 ANXA2 0 0 801 806 1 1
PSEN1 SEMA3A 0 0 134 152 1 1
PSEN1 NOS3 0 0 253 287 1 2
PSEN1 CCND1 0 0 324 323 1 2
PSEN1 ENSG00000273171 0 0 0 188 1 1
PSEN1 FOXO3 0 0 235 259 1 2
PSEN1 PLB1 0 0 212 212 1 1
PSEN1 SLC2A4 0 0 181 203 1 1
PSEN1 ATXN2 0 0 167 180 1 1
PSEN1 SLC24A4 0 0 342 363 1 1
PSEN1 APOE 0 0 896 902 1 2
PSEN1 LRP8 0 0 391 405 1 1
PSEN1 TFCP2 0 0 150 169 1 1
PSEN1 CDC42 0 0 201 250 1 2
PSEN1 MPHOSPH8 0 0 0 160 1 1
PSEN1 DKK1 0 0 174 186 1 1
PSEN1 NAGLU 0 0 96 361 1 1
PSEN1 COL28A1 0 0 0 176 1 1
PSEN1 XPNPEP3 0 0 142 210 1 1
PSEN1 ATG3 0 0 202 256 1 2
PSEN1 DNAJB1 0 0 143 174 1 2
PSEN1 BIRC6 0 0 0 181 1 1
PSEN1 SYT3 0 0 55 174 1 1
PSEN1 RTN3 0 0 250 269 1 1
PSEN1 ELTD1 0 0 0 176 1 1
PSEN1 JMJD7-PLA2G4B 0 0 0 161 1 1
PSEN1 COMT 0 0 211 215 1 1
PSEN1 HNF4A 0 0 171 204 1 1
PSEN1 DCX 0 0 467 477 1 1
PSEN1 EGFL6 0 0 0 176 1 1
PSEN1 TBK1 0 0 235 271 1 2
PSEN1 PRH1 0 0 242 241 1 1
PSEN1 FOXP3 0 0 206 206 1 2
PSEN1 CACNA1A 0 0 181 187 1 1
PSEN1 RPL26L1 0 0 47 151 1 1
PSEN1 SORCS1 0 0 325 340 1 1
PSEN1 KDR 0 0 139 228 1 2
PSEN1 ABCC9 0 0 270 278 1 1
PSEN1 RAB11A 192 0 936 950 1 2
PSEN1 RAC2 0 0 112 197 1 1
PSEN1 MARCH5 0 0 134 261 1 1
PSEN1 CCDC109B 0 0 46 150 1 1
PSEN1 TGFB1 0 0 150 242 1 2
PSEN1 VDAC1 168 0 341 447 1 2
PSEN1 RAB7B 0 0 341 352 1 1
PSEN1 GLUL 0 0 306 321 1 1
PSEN1 HAP1 0 0 134 152 1 1
PSEN1 TEP1 0 0 0 157 1 1
PSEN1 PGA3 0 0 0 288 1 1
PSEN1 MMP10 0 0 71 164 1 1
PSEN1 CRMP1 0 0 143 180 1 1
PSEN1 GRIK1 0 0 81 204 1 1
PSEN1 FBN2 0 0 45 342 1 1
PSEN1 CSF2 0 0 211 211 1 1
PSEN1 EFNB3 0 0 56 167 1 1
PSEN1 NPDC1 0 0 81 180 1 1
PSEN1 MAGEL2 0 0 66 358 1 1
PSEN1 FBN3 0 0 0 339 1 1
PSEN1 DYSF 0 0 90 218 1 1
PSEN1 PPP1R9B 0 0 157 158 1 1
PSEN1 SPPL2B 130 0 212 443 1 1
PSEN1 VCAM1 0 0 167 167 1 1
PSEN1 INPP5D 0 0 334 334 1 1
PSEN1 ATP2A3 0 0 91 263 1 1
PSEN1 PCYOX1L 0 0 0 227 1 1
PSEN1 SUMO1 0 0 138 165 1 1
PSEN1 TPT1 0 0 112 199 1 1
PSEN1 SCN5A 0 0 138 164 1 1
PSEN1 NTRK2 0 0 457 471 1 1
PSEN1 CALR3 0 0 0 332 1 1
PSEN1 ATP7A 0 0 134 249 1 1
PSEN1 PSMD5 0 0 335 339 1 1
PSEN1 PARL 0 0 537 741 1 1
PSEN1 TMED10 289 900 469 976 1 1
PSEN1 PLXDC2 270 0 66 289 1 1
PSEN1 CST3 0 0 325 325 1 1
PSEN1 ABCF3 0 0 0 151 1 1
PSEN1 GJA1 0 0 173 173 1 1
PSEN1 PPP3CA 0 0 166 330 1 1
PSEN1 EFEMP1 0 0 45 179 1 1
PSEN1 ZSCAN4 0 0 134 186 1 1
PSEN1 MAG 0 0 162 194 1 1
PSEN1 OTOF 0 0 0 176 1 1
PSEN1 GRM5 0 0 261 313 1 1
PSEN1 PINK1 0 0 520 656 1 2
PSEN1 BCL6 0 0 107 151 1 1
PSEN1 UBQLN1 695 0 726 946 1 1
PSEN1 NFATC4 0 0 167 167 1 1
PSEN1 CERS4 0 0 57 151 1 1
PSEN1 PDE5A 0 0 233 250 1 1
PSEN1 MYOF 0 0 0 176 1 1
PSEN1 GPT 0 0 166 165 1 1
PSEN1 RNF103 0 0 0 177 1 1
PSEN1 SUSD1 0 0 0 176 1 1
PSEN1 RTN4 0 0 257 256 1 1
PSEN1 HSP90AB1 0 0 74 154 1 2
PSEN1 AXL 0 0 184 205 1 2
PSEN1 CRB1 0 0 0 491 1 1
PSEN1 CREM 0 0 60 154 1 1
PSEN1 FBN1 0 0 45 342 1 1
PSEN1 PRKRA 0 0 0 194 1 1
PSEN1 ITM2B 0 0 455 455 1 1
PSEN1 TPM3 0 0 151 157 1 1
PSEN1 TH 0 0 378 385 1 2
PSEN1 DENR 0 0 182 195 1 1
PSEN1 RNASET2 0 0 70 205 1 1
PSEN1 NGF 0 900 530 952 1 2
PSEN1 ECE1 0 0 320 361 1 1
PSEN1 CD34 0 0 150 190 1 2
PSEN1 FOXO1 0 0 193 193 1 2
PSEN1 RAB39B 0 0 124 151 1 1
PSEN1 CDK9 0 0 0 162 1 1
PSEN1 SOD2 0 0 322 327 1 2
PSEN1 HSPA5 0 0 369 383 1 2
PSEN1 DNM1 0 0 281 346 1 1
PSEN1 NRAS 130 0 46 231 1 1
PSEN1 CAMK4 0 0 167 207 1 1
PSEN1 BTRC 0 0 112 162 1 1
PSEN1 PICALM 0 0 685 715 1 1
PSEN1 PKP4 462 0 870 929 1 1
PSEN1 PISD 0 0 91 176 1 1
PSEN1 HM13 0 0 592 739 1 1
PSEN1 SNCB 0 0 378 378 1 1
PSEN1 YWHAZ 0 0 215 284 1 1
PSEN1 HEY2 0 0 213 262 1 1
PSEN1 FOS 0 0 325 325 1 2
PSEN1 PGBD1 0 0 216 286 1 1
PSEN1 RPL10 270 0 52 278 1 1
PSEN1 APLP1 0 0 519 580 1 1
PSEN1 PGF 0 0 57 226 1 1
PSEN1 CDK5R1 0 0 419 419 1 1
PSEN1 CDT1 0 0 410 410 1 1
PSEN1 ATP6V0A4 0 0 0 251 1 1
PSEN1 SEMA5A 0 0 112 153 1 1
PSEN1 PDIA3 0 0 122 162 1 1
PSEN1 GLIS3 0 0 97 177 1 1
PSEN1 GRID2 0 0 91 152 1 2
PSEN1 DGKE 0 0 0 231 1 1
PSEN1 CHCHD10 0 0 213 214 1 1
PSEN1 TLR2 0 0 283 282 1 2
PSEN1 CERS6 0 0 48 170 1 1
PSEN1 LRP2 0 0 321 337 1 1
PSEN1 RBM15 0 0 74 183 1 1
PSEN1 PHB 0 0 454 454 1 1
PSEN1 GRIN2B 0 0 506 554 1 1
PSEN1 RFNG 0 0 94 185 1 1
PSEN1 GNAO1 0 0 480 480 1 1
PSEN1 LRRK2 0 0 561 595 1 2
PSEN1 SDC1 0 0 166 177 1 1
PSEN1 PTGES 0 0 162 161 1 1
PSEN1 MAOB 0 0 391 427 1 1
PSEN1 RNF130 0 0 181 181 1 1
PSEN1 STT3A 47 0 428 494 1 1
PSEN1 SNAPIN 0 0 150 181 1 1
PSEN1 ARF6 0 0 162 209 1 1
PSEN1 STXBP1 270 0 145 376 1 1
PSEN1 ARPC5L 0 0 0 157 1 1
PSEN1 SEPT8 0 0 52 163 1 1
PSEN1 GRM1 0 0 113 199 1 1
PSEN1 PPIA 0 0 150 174 1 1
PSEN1 TRPC4 0 0 90 162 1 1
PSEN1 CSTB 0 0 249 265 1 1
PSEN1 SYS1 0 0 0 193 1 1
PSEN1 NOTCH2 213 900 543 979 1 1
PSEN1 CYP46A1 0 0 381 381 1 1
PSEN1 GDI1 213 0 0 232 1 1
PSEN1 PTPN5 0 0 211 228 1 1
PSEN1 PSMA5 270 0 75 322 1 1
PSEN1 ALOX5 0 0 246 276 1 1
PSEN1 ATG12 0 0 245 244 1 2
PSEN1 AFP 0 0 181 199 1 2
PSEN1 NFIB 0 0 0 618 1 1
PSEN1 LIMK1 0 0 124 160 1 1
PSEN1 TNFRSF21 0 0 255 254 1 1
PSEN1 SLC23A2 0 0 215 220 1 1
PSEN1 ATP6V1B2 0 0 74 172 1 1
PSEN1 AP1G1 0 0 455 503 1 1
PSEN1 NQO1 0 0 162 224 1 2
PSEN1 KCNIP1 0 0 306 306 1 1
PSEN1 HYPK 0 0 54 500 1 1
PSEN1 TRPM2 0 0 157 156 1 2
PSEN1 HSPB8 0 0 113 469 1 2
PSEN1 MMP14 0 0 143 569 1 1
PSEN1 CKB 0 0 134 171 1 1
PSEN1 HDAC1 0 0 243 286 1 2
PSEN1 CSF1 0 0 218 218 1 1
PSEN1 PLA2G4B 0 0 0 161 1 1
PSEN1 PI4KA 0 0 0 161 1 1
PSEN1 TMEM106B 0 0 324 323 1 1
PSEN1 AP1M2 0 0 0 163 1 1
PSEN1 TSPO 0 0 367 367 1 1
PSEN1 ENSG00000242631 0 0 0 156 1 1
PSEN1 NDUFS8 271 0 0 271 1 1
PSEN1 WNT2 0 0 91 194 1 1
PSEN1 DAB1 0 0 134 188 1 1
PSEN1 CUL3 0 0 97 160 1 2
PSEN1 CASP4 213 0 201 359 1 2
PSEN1 SST 0 0 217 217 1 1
PSEN1 FABP4 0 0 0 188 1 1
PSEN1 POGLUT1 0 0 90 165 1 1
PSEN1 ITGAX 0 0 212 225 1 1
PSEN1 NUB1 0 0 183 208 1 1
PSEN1 NECAB1 0 0 0 203 1 1
PSEN1 NUDT16 0 0 0 181 1 1
PSEN1 CTSD 0 0 460 494 1 2
PSEN1 AXIN1 0 0 317 336 1 1
PSEN1 SHC1 0 0 160 159 1 1
PSEN1 ATM 0 0 163 188 1 2
PSEN1 VTI1B 0 0 92 152 1 2
PSEN1 KCTD12 0 0 394 394 1 1
PSEN1 FERMT2 0 0 358 358 1 1
PSEN1 RAD23B 0 0 0 238 1 1
PSEN1 NRXN1 0 0 218 218 1 1
PSEN1 NRGN 0 0 249 248 1 1
PSEN1 KLK6 0 0 167 173 1 1
PSEN1 NT5C1A 0 0 157 156 1 1
PSEN1 ICT1 0 0 165 200 1 1
PSEN1 CA4 0 0 261 307 1 1
PSEN1 TJP1 0 0 445 445 1 1
PSEN1 ATG7 0 0 322 331 1 2
PSEN1 CDH11 0 0 81 160 1 1
PSEN1 SYT2 0 0 64 280 1 1
PSEN1 RPL21 0 0 67 479 1 1
PSEN1 ACTG1 0 0 207 228 1 1
PSEN1 SLC30A7 0 0 112 150 1 1
PSEN1 GFAP 270 0 611 742 1 2
PSEN1 SYTL2 0 0 0 161 1 1
PSEN1 ATP6V0A1 0 0 71 294 1 1
PSEN1 EFNB2 213 0 184 436 1 1
PSEN1 NPAP1 0 0 67 229 1 1
PSEN1 SNX17 0 0 154 153 1 1
PSEN1 NAMPT 0 0 162 161 1 2
PSEN1 VWA1 0 0 0 176 1 1
PSEN1 RBPJ 0 0 501 766 1 1
PSEN1 SDC3 0 900 113 907 1 1
PSEN1 ATP9A 168 0 0 202 1 1
PSEN1 VEGFA 0 0 370 370 1 2
PSEN1 NFIA 0 0 57 368 1 1
PSEN1 GABARAP 0 0 184 195 1 2
PSEN1 MBP 0 0 287 286 1 2
PSEN1 PTEN 0 0 294 370 1 2
PSEN1 NCOA6 0 0 0 311 1 1
PSEN1 DNM1L 0 0 391 442 1 2
PSEN1 PANK2 0 0 150 208 1 1
PSEN1 WIPI1 0 0 123 203 1 2
PSEN1 AGPS 0 0 147 166 1 1
PSEN1 RHBDL2 0 0 0 536 1 1
PSEN1 PRKAA2 0 0 134 168 1 2
PSEN1 GOSR2 0 0 95 302 1 1
PSEN1 TCF4 0 0 72 477 1 1
PSEN1 ZBTB33 0 0 161 236 1 1
PSEN1 ASTN2 0 0 444 444 1 1
PSEN1 NFKBIA 0 0 209 213 1 2
PSEN1 HFE 0 0 180 200 1 1
PSEN1 SYT5 0 0 66 183 1 1
PSEN1 RHOT2 0 0 72 223 1 1
PSEN1 LEP 0 0 307 312 1 1
PSEN1 SYK 0 0 149 172 1 2
PSEN1 NDUFA9 282 0 107 344 1 1
PSEN1 CFL1 0 0 322 337 1 1
PSEN1 MAPK14 0 0 188 300 1 2
PSEN1 ENSG00000258947 0 0 123 239 1 1
PSEN1 MAPK10 0 0 202 241 1 2
PSEN1 CTSB 0 0 496 517 1 2
PSEN1 SPI1 0 0 218 218 1 1
PSEN1 CST7 0 0 281 286 1 1
PSEN1 CTF1 0 0 283 343 1 1
PSEN1 DLK1 0 0 150 269 1 1
PSEN1 SIRT1 0 0 464 470 1 2
PSEN1 PCDH1 0 0 51 183 1 1
PSEN1 MAP3K5 0 0 195 212 1 1
PSEN1 ITGAM 0 0 366 377 1 1
PSEN1 BACE1 270 0 977 985 1 2
PSEN1 EYA4 0 0 103 275 1 1
PSEN1 PPP1CA 0 0 91 304 1 1
PSEN1 HMGB1 0 0 145 226 1 2
PSEN1 RAC1 0 0 140 185 1 2
PSEN1 AFG3L2 0 0 54 173 1 1
PSEN1 ATG5 0 0 320 343 1 2
PSEN1 SCARF2 0 0 0 190 1 1
PSEN1 CHRNB2 0 0 194 216 1 1
PSEN1 WNT3A 0 0 202 235 1 2
PSEN1 PPP5D1 0 0 0 152 1 1
PSEN1 GRIN1 0 0 231 594 1 1
PSEN1 TIA1 0 0 143 202 1 1
PSEN1 CRH 0 0 201 201 1 1
PSEN1 SCARF1 0 0 0 254 1 1
PSEN1 GRM2 0 0 81 152 1 1
PSEN1 SNX6 0 0 123 160 1 1
PSEN1 XBP1 0 0 203 266 1 2
PSEN1 PTPN1 0 0 146 187 1 1
PSEN1 FUS 0 0 506 522 1 2
PSEN1 ATG10 0 0 134 166 1 2
PSEN1 TGFBR1 270 0 150 373 1 1
PSEN1 HSPB1 0 0 180 243 1 2
PSEN1 ADAM19 0 0 150 280 1 1
PSEN1 MGLL 0 0 174 173 1 1
PSEN1 COL22A1 0 0 0 176 1 1
PSEN1 DYRK1A 0 0 324 338 1 1
PSEN1 HSPB2 0 0 166 231 1 1
PSEN1 ISG15 0 0 0 158 1 2
PSEN1 ZCCHC17 0 0 160 159 1 1
PSEN1 ADAM17 0 0 556 636 1 1
PSEN1 ARID1A 0 0 0 235 1 1
PSEN1 GALP 0 0 180 179 1 1
PSEN1 VWDE 0 0 0 176 1 1
PSEN1 RPS6KA1 0 0 138 172 1 1
PSEN1 SEL1L 0 0 54 315 1 1
PSEN1 STMN1 0 0 145 198 1 1
PSEN1 NR2E3 0 0 0 160 1 1
PSEN1 DACH1 0 0 0 167 1 1
PSEN1 NCAM1 0 0 193 193 1 1
PSEN1 CASR 0 0 108 189 1 2
PSEN1 VTN 0 0 82 222 1 1
PSEN1 C1QC 0 0 122 171 1 1
PSEN1 GPX1 0 0 156 171 1 1
PSEN1 RCOR1 0 0 81 205 1 1
PSEN1 AKT3 0 0 72 159 1 2
PSEN1 RCOR3 0 0 0 171 1 1
PSEN1 ADAM20 0 0 0 343 1 1
PSEN1 GOLPH3 0 0 183 203 1 1
PSEN1 C9orf72 0 0 611 611 1 2
PSEN1 SLC2A3 270 0 261 453 1 1
PSEN1 SYTL3 0 0 0 161 1 1
PSEN1 LRP5 0 0 144 252 1 1
PSEN1 SOAT1 47 0 205 209 1 1
PSEN1 FLNA 461 0 138 614 1 1
PSEN1 LRP1B 0 0 161 187 1 1
PSEN1 CTSE 0 0 328 370 1 1
PSEN1 OASL 0 0 0 158 1 1
PSEN1 GRIN3B 0 0 95 198 1 1
PSEN1 SYNJ1 0 0 282 291 1 1
PSEN1 SYT13 0 0 54 173 1 1
PSEN1 STK11 0 0 134 151 1 2
PSEN1 BRCA1 0 0 180 179 1 2
PSEN1 OPA1 0 0 464 546 1 2
PSEN1 B4GALNT1 0 0 151 150 1 1
PSEN1 TCF3 0 0 68 214 1 1
PSEN1 AQP1 0 0 144 166 1 1
PSEN1 RB1CC1 0 0 143 165 1 2
PSEN1 TDGF1 0 0 49 183 1 1
PSEN1 ENSG00000249141 0 0 0 181 1 1
PSEN1 ATCAY 0 0 0 153 1 1
PSEN1 PPP1R1B 0 0 193 193 1 1
PSEN1 SCUBE3 0 0 0 176 1 1
PSEN1 ABI3 0 0 269 317 1 1
PSEN1 PRB1 0 0 306 306 1 1
PSEN1 SCARB2 0 0 167 167 1 1
PSEN1 ADAM10 312 0 715 907 1 1
PSEN1 BTBD9 0 0 113 263 1 1
PSEN1 HORMAD1 0 0 0 251 1 1
PSEN1 ADNP 0 0 141 171 1 1
PSEN1 PPARGC1A 0 0 365 366 1 2
PSEN1 PRB4 0 0 262 262 1 1
PSEN1 SLC1A3 0 0 289 308 1 1
PSEN1 UCK2 0 0 0 154 1 1
PSEN1 MATN2 0 0 0 339 1 1
PSEN1 PPP5C 0 0 0 177 1 1
PSEN1 WNT5A 0 0 147 183 1 2
PSEN1 PGA5 0 0 67 307 1 1
PSEN1 PARK2 0 0 558 610 1 1
PSEN1 SYT17 0 0 57 175 1 1
PSEN1 LGMN 0 0 137 231 1 1
PSEN1 LRP5L 0 0 0 162 1 1
PSEN1 PROS1 0 0 289 288 1 1
PSEN1 GAB2 0 0 335 335 1 1
PSEN1 VAPA 0 0 95 169 1 1
PSEN1 P4HB 0 0 210 215 1 2
PSEN1 TMBIM6 747 0 73 839 1 1
PSEN1 VASN 270 0 94 323 1 1
PSEN1 ADORA1 0 0 157 173 1 1
PSEN1 DVL1 0 0 95 153 1 1
PSEN1 GNAQ 0 0 112 154 1 1
PSEN1 SCN2A 0 0 166 172 1 1
PSEN1 ARHGEF28 0 0 156 163 1 1
PSEN1 CLU 0 0 681 684 1 2
PSEN1 CALM3 0 0 161 213 1 1
PSEN1 CDH3 0 0 329 346 1 1
PSEN1 JAK2 0 0 193 217 1 2
PSEN1 MTCH1 462 0 875 930 1 1
PSEN1 KIAA1324L 0 0 0 176 1 1
PSEN1 ZDHHC15 0 0 0 248 1 1
PSEN1 CDH2 270 0 981 987 1 1
PSEN1 APAF1 0 0 124 289 1 2
PSEN1 HDAC6 0 0 235 240 1 2
PSEN1 EIF2AK4 0 0 204 205 1 2
PSEN1 RHBDL3 0 0 0 564 1 1
PSEN1 GDNF 0 0 342 342 1 2
PSEN1 ITGA5 0 0 47 193 1 1
PSEN1 CHRFAM7A 0 0 138 203 1 1
PSEN1 KCND3 0 0 293 293 1 1
PSEN1 SPTLC1 0 0 113 207 1 1
PSEN1 PCSK5 0 0 61 160 1 1
PSEN1 RAB8A 0 0 124 164 1 2
PSEN1 GCLM 0 0 108 267 1 1
PSEN1 MYH6 0 0 112 150 1 1
PSEN1 MCOLN1 0 0 287 300 1 2
PSEN1 NEDD8 0 0 94 201 1 2
PSEN1 SLC2A1 0 0 239 260 1 2
PSEN1 LAMP1 0 0 370 394 1 2
PSEN1 MS4A4E 0 0 156 170 1 1
PSEN1 FGFR3 0 900 67 905 1 1
PSEN1 HTT 0 0 602 663 1 2
PSEN1 PPP1CC 0 0 47 232 1 1
PSEN1 ATP2C1 0 0 61 175 1 1
PSEN1 CFLAR 0 0 139 157 1 2
PSEN1 EGFR 0 0 359 403 1 2
PSEN1 CTNNA1 270 0 81 312 1 1
PSEN1 KIF5C 0 0 106 151 1 1
PSEN1 MAOA 0 0 288 329 1 1
PSEN1 ALOX15 0 0 123 158 1 1
PSEN1 RASEF 0 0 0 163 1 1
PSEN1 DOCK3 213 0 432 533 1 1
PSEN1 MDM2 0 0 450 450 1 2
PSEN1 TP53 0 0 452 458 1 2
PSEN1 CFDP1 0 0 0 189 1 1
PSEN1 FER1L5 0 0 0 176 1 1
PSEN1 FLNB 270 0 72 438 1 1
PSEN1 ZBTB11 0 0 66 183 1 1
PSEN1 NR1H2 0 0 53 152 1 1
PSEN1 GUK1 0 0 0 158 1 1
PSEN1 PPP2R5D 0 0 0 177 1 1
PSEN1 HDAC2 0 0 261 299 1 1
PSEN1 MAP3K7 0 0 94 161 1 2
PSEN1 CD200R1 0 0 150 168 1 1
PSEN1 RAB10 0 0 140 164 1 1
PSEN1 GIG25 0 0 395 394 1 1
PSEN1 HOXC9 0 0 86 159 1 1
PSEN1 RAF1 0 0 123 181 1 2
PSEN1 SCUBE2 0 0 0 176 1 1
PSEN1 QPCT 0 0 325 325 1 1
PSEN1 IRAK1 0 0 125 155 1 1
PSEN1 PLA2G4E 0 0 74 190 1 1
PSEN1 NCOR2 0 0 147 153 1 1
PSEN1 NELL2 0 0 0 176 1 1
PSEN1 CT83 0 0 204 361 1 1
PSEN1 RMDN3 0 0 171 189 1 1
PSEN1 RAD23A 0 0 93 267 1 1
PSEN1 UBL4B 0 0 0 158 1 1
PSEN1 RAD51 0 0 74 150 1 2
PSEN1 MTOR 0 0 407 427 1 2
PSEN1 XPNPEP1 0 0 173 237 1 1
PSEN1 CD163 0 0 123 167 1 1
PSEN1 MRRF 0 0 0 171 1 1
PSEN1 MARK4 0 0 184 206 1 1
PSEN1 HCN2 168 0 0 182 1 1
PSEN1 ZNF462 0 0 0 156 1 1
PSEN1 MMP1 0 0 81 173 1 1
PSEN1 UNC5C 0 0 157 156 1 1
PSEN1 ELAVL3 0 0 146 154 1 1
PSEN1 GRM8 0 0 52 159 1 1
PSEN1 HGFAC 0 0 74 211 1 1
PSEN1 STAT1 0 0 164 177 1 2
PSEN1 OCLN 0 0 242 259 1 1
PSEN1 DCST2 0 0 0 346 1 1
PSEN1 NPHS1 0 0 49 232 1 1
PSEN1 PDS5B 0 0 67 166 1 1
PSEN1 PIK3C3 0 0 217 240 1 2
PSEN1 SMN1 0 0 180 223 1 1
PSEN1 ETS2 0 0 181 181 1 1
PSEN1 PPP4C 0 0 0 423 1 1
PSEN1 NBPF15 0 0 468 468 1 1
PSEN1 MOG 0 0 202 202 1 1
PSEN1 CTRL 0 0 290 295 1 2
PSEN1 CXCL8 0 0 245 244 1 2
PSEN1 VSTM2L 0 0 113 168 1 1
PSEN1 ATXN1 0 0 287 286 1 1
PSEN1 CTSL 0 0 171 186 1 2
PSEN1 SLC1A7 0 0 157 179 1 1
PSEN1 NEDD4 0 0 56 283 1 2
PSEN1 BAG3 0 0 124 180 1 2
PSEN1 MYBPC3 0 0 166 188 1 1
PSEN1 RAB5A 0 0 343 377 1 2
PSEN1 CNBP 0 0 50 181 1 1
PSEN1 SMPD3 0 0 184 183 1 1
PSEN1 NR1H3 0 0 69 161 1 1
PSEN1 C3AR1 0 0 162 161 1 1
PSEN1 SUPT4H1 0 0 0 157 1 1
PSEN1 GTF2H5 0 0 60 158 1 1
PSEN1 ARC 0 0 323 672 1 2
PSEN1 CACNA1C 0 0 210 216 1 1
PSEN1 HRAS 130 0 205 374 1 2
PSEN1 CTNNB1 872 900 989 999 1 2
PSEN1 DLK2 0 0 97 255 1 1
PSEN1 EGR1 0 0 261 296 1 2
PSEN1 FBLN7 0 0 0 176 1 1
PSEN1 APP 973 900 955 999 1 2
PSEN1 MFN2 0 0 407 450 1 2
PSEN1 KIAA0319 0 0 263 263 1 1
PSEN1 NFKB1 0 0 142 188 1 2
PSEN1 NPR1 270 0 102 316 1 1
PSEN1 RELA 0 0 105 154 1 2
PSEN1 LRRCC1 0 0 71 232 1 1
PSEN1 HPS6 0 0 0 157 1 1
PSEN1 PDHA1 0 0 87 153 1 1
PSEN1 CASP6 213 0 253 400 1 1
PSEN1 ZDHHC24 0 0 0 255 1 1
PSEN1 LSM12 0 0 0 169 1 1
PSEN1 GPR3 0 0 248 248 1 1
PSEN1 FKBP8 270 0 442 593 1 1
PSEN1 RD3 0 0 155 154 1 1
PSEN1 NEFM 0 0 205 205 1 1
PSEN1 TCF7L2 462 0 96 503 1 1
PSEN1 MAP2K7 0 0 203 247 1 1
PSEN1 CX3CL1 0 0 325 326 1 1
PSEN1 PTBP1 0 0 108 196 1 2
PSEN1 ABL1 0 0 161 187 1 1
PSEN1 ENO1 0 0 180 179 1 1
PSEN1 SYT15 0 0 58 177 1 1
PSEN1 GAPDH 0 0 505 543 1 2
PSEN1 TRPC3 0 0 138 206 1 1
PSEN1 SPSB1 0 0 47 167 1 1
PSEN1 HEYL 0 0 204 218 1 1
PSEN1 HIST2H2AC 0 0 427 431 1 1
PSEN1 DHX9 271 0 0 293 1 1
PSEN1 WWP1 0 0 0 159 1 1
PSEN1 STARD3NL 0 0 0 183 1 1
PSEN1 APC 0 0 95 163 1 1
PSEN1 ENTPD7 0 0 0 190 1 1
PSEN1 CREB1 0 0 594 643 1 2
PSEN1 EFNB1 0 0 140 312 1 1
PSEN1 TMEM119 0 0 310 309 1 1
PSEN1 UBE2D3 0 0 74 198 1 1
PSEN1 CREBBP 0 0 263 311 1 1
PSEN1 PPID 0 0 159 211 1 1
PSEN1 FIG4 0 0 142 183 1 1
PSEN1 RHOBTB2 0 0 107 152 1 1
PSEN1 RYR2 270 0 401 598 1 1
PSEN1 TPCN2 0 0 170 178 1 1
PSEN1 GRIK2 0 0 139 217 1 1
PSEN1 MRPL34 0 0 0 183 1 1
PSEN1 SIRT2 0 0 315 315 1 2
PSEN1 SERPINI1 0 0 258 258 1 1
PSEN1 COL25A1 0 0 209 209 1 1
PSEN1 PSAP 0 0 119 321 1 1
PSEN1 AGAP2 0 0 103 185 1 1
PSEN1 PIANP 0 0 207 247 1 1
PSEN1 CNTN1 0 900 113 908 1 1
PSEN1 NKTR 0 0 209 256 1 1
PSEN1 CTNND1 678 0 939 980 1 1
PSEN1 NRG2 0 900 54 903 1 1
PSEN1 NOS1AP 0 0 170 170 1 1
PSEN1 IRF6 0 0 167 167 1 1
PSEN1 TREM2 270 0 710 782 1 1
PSEN1 ENSG00000270024 0 0 57 177 1 1
PSEN1 PRKACB 0 800 88 817 1 1
PSEN1 MFN1 0 0 340 388 1 2
PSEN1 IRS2 0 0 204 205 1 1
PSEN1 UCHL1 0 0 398 398 1 2
PSEN1 GAP43 270 0 322 483 1 1
PSEN1 APBB1 0 0 560 570 1 1
PSEN1 TRPC5 0 0 120 189 1 1
PSEN1 SOD1 0 0 557 590 1 2
PSEN1 EYS 0 0 0 220 1 1
PSEN1 GRB2 0 0 822 839 1 1
PSEN1 GRIN2A 0 0 539 607 1 1
PSEN1 FYN 0 0 392 415 1 1
PSEN1 JAG1 0 0 426 656 1 1
PSEN1 FST 0 0 81 193 1 1
PSEN1 JUN 0 0 530 530 1 2
PSEN1 NRG3 0 900 135 909 1 1
PSEN1 DAPK1 0 0 124 196 1 2
PSEN1 CLUL1 0 0 0 195 1 1
PSEN1 TRIM11 0 0 357 357 1 1
PSEN1 ITGAL 0 0 178 191 1 1
PSEN1 CDH17 0 0 977 978 1 1
PSEN1 DPYSL2 0 0 288 303 1 1
PSEN1 ERBB4 0 900 406 942 1 1
PSEN1 KIF1B 0 0 113 202 1 1
PSEN1 ECE2 0 0 325 365 1 1
PSEN1 AIF1 0 0 681 681 1 2
PSEN1 CHRNA7 0 0 171 234 1 1
PSEN1 ICAM5 270 0 943 957 1 1
PSEN1 BOK 0 0 0 202 1 1
PSEN1 ITIH3 0 0 0 191 1 1
PSEN1 DNTT 0 0 181 181 1 1
PSEN1 NOS1 0 0 227 262 1 1
PSEN1 CCNA2 0 0 134 152 1 1
PSEN1 INA 0 0 133 154 1 1
PSEN1 SEZ6L 0 0 65 163 1 1
PSEN1 GORASP2 0 0 113 172 1 1
PSEN1 MFNG 0 0 140 226 1 1
PSEN1 MKRN2 0 0 0 182 1 1
PSEN1 BNIP3 0 0 134 192 1 2
PSEN1 SQSTM1 0 0 391 429 1 2
PSEN1 SLC11A2 0 0 195 195 1 1
PSEN1 HMCN2 0 0 0 232 1 1
PSEN1 ABCG1 0 0 210 240 1 2
PSEN1 PLD6 0 0 46 213 1 1
PSEN1 THY1 0 0 561 602 1 1
PSEN1 MAPK3 0 0 381 399 1 2
PSEN1 MMP9 0 0 334 357 1 2
PSEN1 GPR34 0 0 146 174 1 1
PSEN1 MRPL32 0 0 0 152 1 1
PSEN1 ATG13 0 0 151 150 1 2
PSEN1 UGCG 0 0 142 175 1 1
PSEN1 VPS13C 0 0 181 181 1 1
PSEN1 CRP 0 0 233 232 1 2
PSEN1 TP73 0 0 0 330 1 2
PSEN1 PSMA2 47 0 60 157 1 1
PSEN1 SYT1 0 0 851 913 1 1
PSEN1 SET 0 0 96 264 1 1
PSEN1 SOX2 0 0 283 321 1 2
PSEN1 CFC1 0 0 0 176 1 1
PSEN1 HIST2H2AA3 0 0 172 178 1 1
PSEN1 HSP90AA1 0 0 277 292 1 2
PSEN1 POFUT1 0 0 150 321 1 1
PSEN1 DPP6 0 0 95 205 1 1
PSEN1 C4BPA 0 0 160 159 1 1
PSEN1 PTGER2 0 0 112 173 1 1
PSEN1 ICAM1 0 0 202 202 1 2
PSEN1 RHBDF2 0 0 100 238 1 1
PSEN1 GIGYF2 0 0 167 193 1 1
PSEN1 SYTL1 0 0 0 161 1 1
PSEN1 BCR 0 0 462 462 1 2
PSEN1 PTPRC 0 0 325 337 1 1
PSEN1 IGFBP2 0 0 108 169 1 1
PSEN1 ITGAV 0 0 61 204 1 1
PSEN1 TIMP1 0 0 153 152 1 1
PSEN1 KIAA1324 0 0 0 176 1 1
PSEN1 BAX 0 0 165 169 1 2
PSEN1 TNNI3 0 0 113 195 1 1
PSEN1 SYN1 0 0 502 536 1 1
PSEN1 STX6 0 0 160 178 1 1
PSEN1 STX1A 0 0 610 613 1 1
PSEN1 AR 0 0 181 195 1 2
PSEN1 AP5Z1 0 0 125 154 1 1
PSEN1 GSN 0 0 244 253 1 1
PSEN1 ATG9A 0 0 74 151 1 2
PSEN1 CDKN1A 0 0 144 163 1 2
PSEN1 SLC32A1 0 0 170 169 1 1
PSEN1 CSF2RA 0 0 135 161 1 1
PSEN1 VPS35 0 0 484 540 1 2
PSEN1 EPM2A 0 0 127 164 1 2
PSEN1 CD33 0 0 528 528 1 1
PSEN1 PRKCZ 213 0 122 316 1 1
PSEN1 HES7 0 0 217 230 1 1
PSEN1 COX10 0 0 150 295 1 1
PSEN1 CDH1 766 900 735 993 1 2
PSEN1 VPS26A 0 0 193 193 1 1
PSEN1 NEUROG2 0 0 189 189 1 1
PSEN1 NRG4 0 900 0 900 1 1
PSEN1 EPHA4 0 0 241 261 1 1
PSEN1 KCNIP3 678 0 937 979 1 1
PSEN1 CNTNAP1 168 0 107 290 1 1
PSEN1 AGER 0 0 468 468 1 2
PSEN1 NEFL 0 0 370 385 1 1
PSEN1 SIRT6 0 0 293 293 1 2
PSEN1 PCDH15 0 0 0 164 1 1
PSEN1 ATP2A1 0 0 143 305 1 1
PSEN1 MAP1B 0 0 167 203 1 2
PSEN1 CYP3A4 0 0 117 155 1 1
PSEN1 SPPL2C 0 0 72 209 1 1
PSEN1 PAX6 0 0 193 193 1 1
PSEN1 WNT1 0 0 205 293 1 2
PSEN1 ROCK2 0 0 108 174 1 1
PSEN1 PPP1CB 0 0 57 241 1 1
PSEN1 MARCH2 0 0 0 237 1 1
PSEN1 ALK 0 0 144 167 1 2
PSEN1 BCHE 0 0 603 615 1 1
PSEN1 DRD2 0 0 181 217 1 1
PSEN1 MAF 0 0 234 234 1 1
PSEN1 PDE4A 0 0 141 221 1 1
PSEN1 SORBS3 0 0 230 307 1 1
PSEN1 ANXA3 0 0 45 191 1 1
PSEN1 PVALB 0 0 363 372 1 1
PSEN1 MS4A6E 0 0 464 463 1 1
PSEN1 SPTBN4 0 0 104 178 1 1
PSEN1 TYROBP 0 0 470 471 1 1
PSEN1 CSNK1D 0 0 112 214 1 1
PSEN1 ELAVL1 0 0 124 150 1 2
PSEN1 CASP7 213 0 155 354 1 1
PSEN1 MME 0 0 659 702 1 1
PSEN1 CUL1 0 0 107 192 1 1
PSEN1 CD68 0 0 459 475 1 2
PSEN1 ALB 0 0 505 535 1 2
PSEN1 CCL2 0 0 370 370 1 2
PSEN1 GABRA4 0 0 57 153 1 1
PSEN1 BIRC3 0 0 67 225 1 1
PSEN1 SMAD3 0 0 161 161 1 2
PSEN1 SPARC 0 0 57 158 1 2
PSEN1 SLC2A13 168 0 0 201 1 1
PSEN1 FER1L6 0 0 0 176 1 1
PSEN1 ROCK1 0 0 181 219 1 2
PSEN1 TARBP2 0 0 58 303 1 1
PSEN1 SNCAIP 0 0 217 221 1 2
PSEN1 DAG1 270 0 90 308 1 1
PSEN1 RABGAP1L 0 0 537 537 1 1
PSEN1 INPP1 0 0 0 169 1 1
PSEN1 SERPINF1 0 0 122 158 1 1
PSEN1 CDK5 213 0 661 763 1 2
PSEN1 EP300 0 0 229 263 1 2
PSEN1 ZCWPW1 0 0 403 403 1 1
PSEN1 NUMB 0 0 340 428 1 1
PSEN1 PDGFRB 0 0 166 165 1 2
PSEN1 LEF1 0 0 291 290 1 1
PSEN1 RAP1B 0 0 42 158 1 1
PSEN1 AP1M1 0 0 0 163 1 1
PSEN1 NMRK1 0 0 0 153 1 1
PSEN1 IL4 0 0 345 345 1 1
PSEN1 CALU 0 0 45 218 1 1
PSEN1 SCARB1 0 0 134 154 1 1
PSEN1 PLD3 0 0 518 518 1 1
PSEN1 SLC8B1 0 0 122 152 1 1
PSEN1 FBLN5 0 0 0 176 1 1
PSEN1 PLAU 0 0 181 181 1 1
PSEN1 SORCS2 0 0 134 241 1 1
PSEN1 EGF 0 0 367 375 1 2
PSEN1 PAWR 0 0 160 159 1 1
PSEN1 GAK 0 0 72 177 1 1
PSEN1 POLR2J 0 0 0 183 1 1
PSEN1 PCSK1 0 0 94 187 1 1
PSEN1 SLC1A2 0 0 391 409 1 1
PSEN1 HTR6 0 0 104 160 1 1
PSEN1 TRAF6 835 900 719 995 1 2
PSEN1 GGA1 0 0 167 167 1 1
PSEN1 CYCS 0 0 408 422 1 2
PSEN1 DUSP12 0 0 136 168 1 1
PSEN1 ELOVL1 0 0 0 157 1 1
PSEN1 SRRT 0 0 169 193 1 1
PSEN1 RAC3 0 0 90 177 1 2
PSEN1 CHAT 0 0 468 479 1 1
PSEN1 HSP90B1 0 0 178 177 1 1
PSEN1 HSPB3 0 0 170 216 1 1
PSEN1 ZNF77 0 0 142 161 1 1
PSEN1 TRPC6 0 0 181 245 1 1
PSEN1 MT-ATP6 0 0 308 307 1 1
PSEN1 VAMP1 0 0 150 168 1 1
PSEN1 PDE6B 0 0 180 193 1 1
PSEN1 CCR2 0 0 289 288 1 2
PSEN1 PPARA 0 0 252 265 1 2
PSEN1 CETP 0 0 128 162 1 1
PSEN1 ACHE 0 0 839 844 1 2
PSEN1 HSPA4 0 0 321 350 1 1
PSEN1 PIK3R1 213 0 124 363 1 1
PSEN1 DICER1 0 0 166 184 1 1
PSEN1 ATP6AP2 0 0 113 179 1 1
PSEN1 CRHR1 0 0 181 181 1 1
PSEN1 NRARP 0 0 165 196 1 1
PSEN1 GPHN 0 0 150 168 1 1
PSEN1 XPNPEP2 0 0 67 285 1 1
PSEN1 P2RX7 0 0 138 178 1 2
PSEN1 PPP2CB 0 0 0 296 1 1
PSEN1 MBTPS2 0 0 195 320 1 1
PSEN1 PRNP 0 0 713 713 1 2
PSEN1 SSH1 0 0 151 166 1 1
PSEN1 BLVRA 0 0 140 158 1 1
PSEN1 MMP16 0 0 66 229 1 1
PSEN1 GRM3 0 0 90 189 1 1
PSEN1 NDUFS7 168 0 59 214 1 1
PSEN1 DIABLO 0 0 134 290 1 2
PSEN1 EFEMP2 0 0 0 176 1 1
PSEN1 ATP6V0D2 0 0 0 642 1 1
PSEN1 LILRB2 0 0 155 154 1 1
PSEN1 MAP2K4 0 0 124 276 1 1
PSEN1 PLD1 0 0 850 874 1 2
PSEN1 MAPK8 0 0 270 314 1 2
PSEN1 REEP1 0 0 142 249 1 1
PSEN1 HBG1 0 0 0 189 1 1
PSEN1 BMP1 0 0 61 205 1 1
PSEN1 MARCH3 0 0 0 211 1 1
PSEN1 CFC1B 0 0 0 176 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0051117 Molecular Function ATPase binding enables IPI
GO:0030165 Molecular Function PDZ domain binding enables IPI
GO:0042500 Molecular Function aspartic endopeptidase activity, intramembrane cleaving enables IDA
GO:0042500 Molecular Function aspartic endopeptidase activity, intramembrane cleaving enables IMP
GO:0004190 Molecular Function aspartic-type endopeptidase activity enables NAS
GO:0008013 Molecular Function beta-catenin binding enables IBA
GO:0008013 Molecular Function beta-catenin binding enables IPI
GO:0045296 Molecular Function cadherin binding enables IBA
GO:0005262 Molecular Function calcium channel activity enables IMP
GO:0004175 Molecular Function endopeptidase activity enables IBA
GO:0004175 Molecular Function endopeptidase activity enables IDA
GO:0004175 Molecular Function endopeptidase activity enables IGI
GO:0004175 Molecular Function endopeptidase activity enables IMP
GO:0070851 Molecular Function growth factor receptor binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0021870 Biological Process Cajal-Retzius cell differentiation involved_in IEA
GO:0006974 Biological Process DNA damage response involved_in IDA
GO:0098712 Biological Process L-glutamate import across plasma membrane involved_in IEA
GO:0007220 Biological Process Notch receptor processing involved_in IBA
GO:0007220 Biological Process Notch receptor processing involved_in IDA
GO:0007220 Biological Process Notch receptor processing involved_in TAS
GO:0007219 Biological Process Notch signaling pathway involved_in IEA
GO:0002286 Biological Process T cell activation involved in immune response involved_in IEA
GO:0050852 Biological Process T cell receptor signaling pathway involved_in IEA
GO:0042987 Biological Process amyloid precursor protein catabolic process involved_in IBA
GO:0042987 Biological Process amyloid precursor protein catabolic process involved_in IDA
GO:0042987 Biological Process amyloid precursor protein catabolic process involved_in IGI
GO:0042987 Biological Process amyloid precursor protein catabolic process involved_in IMP
GO:0042987 Biological Process amyloid precursor protein catabolic process involved_in TAS
GO:0042982 Biological Process amyloid precursor protein metabolic process involved_in IDA
GO:0034205 Biological Process amyloid-beta formation involved_in IDA
GO:0034205 Biological Process amyloid-beta formation involved_in IGI
GO:0034205 Biological Process amyloid-beta formation involved_in IMP
GO:0050435 Biological Process amyloid-beta metabolic process involved_in IBA
GO:0097190 Biological Process apoptotic signaling pathway involved_in IEA
GO:0048143 Biological Process astrocyte activation involved_in IGI
GO:0002265 Biological Process astrocyte activation involved in immune response involved_in IGI
GO:0000045 Biological Process autophagosome assembly involved_in IEA
GO:0001568 Biological Process blood vessel development involved_in IEA
GO:0048854 Biological Process brain morphogenesis involved_in IEA
GO:0070588 Biological Process calcium ion transmembrane transport involved_in IEA
GO:0006816 Biological Process calcium ion transport involved_in IBA
GO:0001708 Biological Process cell fate specification involved_in IEA
GO:0098609 Biological Process cell-cell adhesion acts_upstream_of_or_within IMP
GO:1904646 Biological Process cellular response to amyloid-beta involved_in IGI
GO:0021549 Biological Process cerebellum development involved_in IEA
GO:0021795 Biological Process cerebral cortex cell migration involved_in IEA
GO:0015871 Biological Process choline transport involved_in IEA
GO:0021904 Biological Process dorsal/ventral neural tube patterning involved_in IEA
GO:0030326 Biological Process embryonic limb morphogenesis involved_in IEA
GO:0032469 Biological Process endoplasmic reticulum calcium ion homeostasis acts_upstream_of_or_within IDA
GO:0032469 Biological Process endoplasmic reticulum calcium ion homeostasis involved_in IGI
GO:0032469 Biological Process endoplasmic reticulum calcium ion homeostasis involved_in IMP
GO:0050673 Biological Process epithelial cell proliferation involved_in IEA
GO:0001947 Biological Process heart looping involved_in IEA
GO:0002244 Biological Process hematopoietic progenitor cell differentiation involved_in IEA
GO:0035556 Biological Process intracellular signal transduction involved_in IEA
GO:0007611 Biological Process learning or memory involved_in IGI
GO:0007611 Biological Process learning or memory involved_in TAS
GO:0040011 Biological Process locomotion involved_in IEA
GO:0006509 Biological Process membrane protein ectodomain proteolysis involved_in IBA
GO:0006509 Biological Process membrane protein ectodomain proteolysis involved_in IDA
GO:0007613 Biological Process memory involved_in IGI
GO:0006839 Biological Process mitochondrial transport involved_in IEA
GO:0043011 Biological Process myeloid dendritic cell differentiation involved_in IEA
GO:0043066 Biological Process negative regulation of apoptotic process involved_in IBA
GO:0043066 Biological Process negative regulation of apoptotic process involved_in IDA
GO:0043066 Biological Process negative regulation of apoptotic process involved_in IMP
GO:2001234 Biological Process negative regulation of apoptotic signaling pathway involved_in IEA
GO:0050771 Biological Process negative regulation of axonogenesis involved_in IEA
GO:1904797 Biological Process negative regulation of core promoter binding involved_in IMP
GO:0010629 Biological Process negative regulation of gene expression involved_in IGI
GO:1905598 Biological Process negative regulation of low-density lipoprotein receptor activity NOT involved_in IGI
GO:0043524 Biological Process negative regulation of neuron apoptotic process involved_in IEA
GO:0001933 Biological Process negative regulation of protein phosphorylation involved_in IEA
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IMP
GO:2000059 Biological Process negative regulation of ubiquitin-dependent protein catabolic process involved_in IEA
GO:0003407 Biological Process neural retina development involved_in IEA
GO:0051402 Biological Process neuron apoptotic process involved_in IEA
GO:0070050 Biological Process neuron cellular homeostasis involved_in IEA
GO:0048666 Biological Process neuron development involved_in IEA
GO:0001764 Biological Process neuron migration involved_in IEA
GO:1990535 Biological Process neuron projection maintenance involved_in IGI
GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IMP
GO:0002038 Biological Process positive regulation of L-glutamate import across plasma membrane involved_in IEA
GO:1905908 Biological Process positive regulation of amyloid fibril formation involved_in IGI
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IEA
GO:0043085 Biological Process positive regulation of catalytic activity involved_in IDA
GO:0050820 Biological Process positive regulation of coagulation involved_in IEA
GO:0060999 Biological Process positive regulation of dendritic spine development involved_in IMP
GO:0010628 Biological Process positive regulation of gene expression involved_in IGI
GO:0045821 Biological Process positive regulation of glycolytic process involved_in IGI
GO:0032436 Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved_in IEA
GO:0032092 Biological Process positive regulation of protein binding involved_in IGI
GO:0042307 Biological Process positive regulation of protein import into nucleus involved_in IMP
GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in IEA
GO:0001921 Biological Process positive regulation of receptor recycling involved_in IEA
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IGI
GO:0009791 Biological Process post-embryonic development involved_in IEA
GO:0140249 Biological Process protein catabolic process at postsynapse involved_in IEA
GO:0006486 Biological Process protein glycosylation involved_in IEA
GO:0016485 Biological Process protein processing involved_in IDA
GO:0016485 Biological Process protein processing involved_in IGI
GO:0016485 Biological Process protein processing involved_in IMP
GO:0015031 Biological Process protein transport involved_in IEA
GO:0060828 Biological Process regulation of canonical Wnt signaling pathway involved_in ISS
GO:0010468 Biological Process regulation of gene expression involved_in IGI
GO:0010975 Biological Process regulation of neuron projection development involved_in IMP
GO:0042325 Biological Process regulation of phosphorylation involved_in IDA
GO:0099175 Biological Process regulation of postsynapse organization involved_in IEA
GO:0060075 Biological Process regulation of resting membrane potential involved_in IEA
GO:0048167 Biological Process regulation of synaptic plasticity involved_in IEA
GO:0051966 Biological Process regulation of synaptic transmission, glutamatergic involved_in IEA
GO:0098693 Biological Process regulation of synaptic vesicle cycle involved_in IEA
GO:0006979 Biological Process response to oxidative stress involved_in IEA
GO:0051208 Biological Process sequestering of calcium ion involved_in IEA
GO:0048705 Biological Process skeletal system morphogenesis involved_in IEA
GO:0043589 Biological Process skin morphogenesis involved_in IEA
GO:0051563 Biological Process smooth endoplasmic reticulum calcium ion homeostasis involved_in IBA
GO:0001756 Biological Process somitogenesis involved_in IEA
GO:0050808 Biological Process synapse organization involved_in IGI
GO:0016080 Biological Process synaptic vesicle targeting involved_in IEA
GO:0048538 Biological Process thymus development involved_in IEA
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0000139 Cellular Component Golgi membrane located_in IEA
GO:0030018 Cellular Component Z disc is_active_in IBA
GO:0016235 Cellular Component aggresome located_in IDA
GO:0016324 Cellular Component apical plasma membrane is_active_in IBA
GO:0035577 Cellular Component azurophil granule membrane located_in TAS
GO:0005938 Cellular Component cell cortex is_active_in IBA
GO:0030054 Cellular Component cell junction located_in IDA
GO:0009986 Cellular Component cell surface is_active_in IBA
GO:0005813 Cellular Component centrosome located_in IDA
GO:0035253 Cellular Component ciliary rootlet is_active_in IBA
GO:0043198 Cellular Component dendritic shaft is_active_in IBA
GO:0031901 Cellular Component early endosome membrane located_in IEA
GO:0005783 Cellular Component endoplasmic reticulum is_active_in IBA
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IEA
GO:0070765 Cellular Component gamma-secretase complex part_of IDA
GO:0070765 Cellular Component gamma-secretase complex part_of IGI
GO:0098978 Cellular Component glutamatergic synapse located_in IEA
GO:0030426 Cellular Component growth cone is_active_in IBA
GO:0030426 Cellular Component growth cone located_in IDA
GO:0000776 Cellular Component kinetochore located_in IDA
GO:0005765 Cellular Component lysosomal membrane is_active_in IBA
GO:0016020 Cellular Component membrane located_in IDA
GO:0016020 Cellular Component membrane located_in TAS
GO:0045121 Cellular Component membrane raft is_active_in IBA
GO:0045121 Cellular Component membrane raft located_in IDA
GO:0005743 Cellular Component mitochondrial inner membrane is_active_in IBA
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0031594 Cellular Component neuromuscular junction is_active_in IBA
GO:0043005 Cellular Component neuron projection located_in IDA
GO:0043025 Cellular Component neuronal cell body is_active_in IBA
GO:0031965 Cellular Component nuclear membrane located_in IDA
GO:0005640 Cellular Component nuclear outer membrane located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus located_in IMP
GO:0048471 Cellular Component perinuclear region of cytoplasm is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0098794 Cellular Component postsynapse located_in IEA
GO:0042734 Cellular Component presynaptic membrane located_in IEA
GO:0032991 Cellular Component protein-containing complex part_of IMP
GO:0005791 Cellular Component rough endoplasmic reticulum located_in IDA
GO:0042383 Cellular Component sarcolemma located_in IEA
GO:0005790 Cellular Component smooth endoplasmic reticulum colocalizes_with IDA
GO:0005790 Cellular Component smooth endoplasmic reticulum located_in IDA
GO:0008021 Cellular Component synaptic vesicle located_in IEA
Pathways
Name DB ID
Signaling by ERBB4 Reactome R-HSA-1236394
Nuclear signaling by ERBB4 Reactome R-HSA-1251985
Developmental Biology Reactome R-HSA-1266738
Degradation of the extracellular matrix Reactome R-HSA-1474228
Extracellular matrix organization Reactome R-HSA-1474244
Signaling by NOTCH Reactome R-HSA-157118
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Regulated proteolysis of p75NTR Reactome R-HSA-193692
p75 NTR receptor-mediated signalling Reactome R-HSA-193704
Signaling by NOTCH1 Reactome R-HSA-1980143
Signaling by NOTCH2 Reactome R-HSA-1980145
Cell death signalling via NRAGE, NRIF and NADE Reactome R-HSA-204998
NRIF signals cell death from the nucleus Reactome R-HSA-205043
Activated NOTCH1 Transmits Signal to the Nucleus Reactome R-HSA-2122948
Signaling by NOTCH1 PEST Domain Mutants in Cancer Reactome R-HSA-2644602
Signaling by NOTCH1 in Cancer Reactome R-HSA-2644603
Constitutive Signaling by NOTCH1 PEST Domain Mutants Reactome R-HSA-2644606
EPH-Ephrin signaling Reactome R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Reactome R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Reactome R-HSA-2894862
NOTCH2 Activation and Transmission of Signal to the Nucleus Reactome R-HSA-2979096
EPH-ephrin mediated repulsion of cells Reactome R-HSA-3928665
Axon guidance Reactome R-HSA-422475
Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
Neutrophil degranulation Reactome R-HSA-6798695
Death Receptor Signaling Reactome R-HSA-73887
Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
Signaling by NOTCH3 Reactome R-HSA-9012852
NOTCH3 Activation and Transmission of Signal to the Nucleus Reactome R-HSA-9013507
Signaling by NOTCH4 Reactome R-HSA-9013694
NOTCH4 Activation and Transmission of Signal to the Nucleus Reactome R-HSA-9013700
Noncanonical activation of NOTCH3 Reactome R-HSA-9017802
Nervous system development Reactome R-HSA-9675108
Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
Inclusion body myositis (WP5120) WikiPathways WP5120_r120422
Notch signaling pathway (WP61) WikiPathways WP61_r120637
Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
Notch signaling (WP268) WikiPathways WP268_r117167
DYRK1A (WP5180) WikiPathways WP5180_r122423
Neurogenesis regulation in the olfactory epithelium (WP5265) WikiPathways WP5265_r123524
Canonical and non-canonical Notch signaling (WP3845) WikiPathways WP3845_r123396
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_047431602 1 mRNA transcript variant X8 NC_000014 Reference
XM_047431601 1 mRNA transcript variant X3 NC_000014 Reference
XM_047431600 1 mRNA transcript variant X2 NC_000014 Reference
XM_011536974 3 mRNA transcript variant X6 NC_000014 Reference
XM_011536972 3 mRNA transcript variant X4 NC_000014 Reference
XM_011536973 3 mRNA transcript variant X7 NC_000014 Reference
NM_000021 4 mRNA transcript variant 1 NC_000014 Reference
NM_007318 3 mRNA transcript variant 2 NC_000014 Reference
XM_005267864 4 mRNA transcript variant X1 NC_000014 Reference
XM_005267866 3 mRNA transcript variant X5 NC_000014 Reference