Name | TP53 induced glycolysis regulatory phosphatase |
Alias |
|
Gene_family | Sugar phosphatases |
organism | Homo sapiens |
entrez_id | 57103 |
location | 12p13.32 |
transcript_count | 1 |
exon_count | 6 |
A | B | experiments | database | textmining | combined score | hadb | nhadb |
---|---|---|---|---|---|---|---|
C12orf5 | CASP9 | 0 | 0 | 150 | 168 | 2 | 1 |
C12orf5 | ATG4A | 0 | 0 | 163 | 181 | 2 | 1 |
C12orf5 | FASN | 0 | 0 | 297 | 297 | 2 | 1 |
C12orf5 | RAB8B | 0 | 0 | 0 | 317 | 2 | 1 |
C12orf5 | RPTOR | 0 | 0 | 211 | 211 | 2 | 1 |
C12orf5 | ARG1 | 0 | 0 | 53 | 216 | 2 | 1 |
C12orf5 | PRKAB1 | 0 | 0 | 282 | 282 | 2 | 1 |
C12orf5 | CMBL | 0 | 0 | 0 | 225 | 2 | 1 |
C12orf5 | CASP8 | 0 | 0 | 150 | 168 | 2 | 1 |
C12orf5 | PGK1 | 0 | 0 | 233 | 694 | 2 | 1 |
C12orf5 | INS | 0 | 0 | 235 | 235 | 2 | 1 |
C12orf5 | ACTB | 0 | 0 | 272 | 335 | 2 | 1 |
C12orf5 | DNMT1 | 0 | 0 | 81 | 171 | 2 | 1 |
C12orf5 | SIRT3 | 0 | 0 | 260 | 292 | 2 | 1 |
C12orf5 | KEAP1 | 0 | 0 | 241 | 240 | 2 | 1 |
C12orf5 | SIRT7 | 0 | 0 | 181 | 216 | 2 | 1 |
C12orf5 | GABARAPL1 | 0 | 0 | 181 | 198 | 2 | 1 |
C12orf5 | HSPA8 | 0 | 0 | 102 | 196 | 2 | 1 |
C12orf5 | FUNDC1 | 0 | 0 | 157 | 167 | 2 | 1 |
C12orf5 | IGFBP3 | 0 | 0 | 229 | 228 | 2 | 1 |
C12orf5 | EI24 | 0 | 0 | 209 | 209 | 2 | 1 |
C12orf5 | TFAM | 0 | 0 | 293 | 346 | 2 | 1 |
C12orf5 | BCL2L11 | 0 | 0 | 179 | 179 | 2 | 1 |
C12orf5 | CHEK1 | 0 | 0 | 171 | 181 | 2 | 1 |
C12orf5 | ULK2 | 0 | 0 | 218 | 337 | 2 | 1 |
C12orf5 | CAV1 | 0 | 0 | 261 | 261 | 2 | 1 |
C12orf5 | RAN | 0 | 0 | 0 | 173 | 2 | 1 |
C12orf5 | BCL2L1 | 0 | 0 | 242 | 241 | 2 | 1 |
C12orf5 | GABARAPL2 | 0 | 0 | 160 | 178 | 2 | 1 |
C12orf5 | ANXA5 | 0 | 0 | 193 | 193 | 2 | 1 |
C12orf5 | RAB12 | 0 | 0 | 0 | 317 | 2 | 1 |
C12orf5 | RPS6 | 0 | 0 | 95 | 170 | 2 | 1 |
C12orf5 | SP1 | 0 | 0 | 147 | 173 | 2 | 1 |
C12orf5 | HIF1A | 0 | 0 | 493 | 504 | 2 | 1 |
C12orf5 | STAT3 | 0 | 0 | 193 | 204 | 2 | 1 |
C12orf5 | EZH2 | 0 | 0 | 90 | 157 | 2 | 1 |
C12orf5 | HK2 | 270 | 650 | 936 | 984 | 2 | 1 |
C12orf5 | PARK7 | 0 | 0 | 95 | 224 | 2 | 1 |
C12orf5 | NUPR1 | 0 | 0 | 155 | 154 | 2 | 1 |
C12orf5 | NFE2L2 | 0 | 0 | 232 | 231 | 2 | 1 |
C12orf5 | MYC | 0 | 0 | 457 | 457 | 2 | 1 |
C12orf5 | PDK1 | 0 | 0 | 458 | 475 | 2 | 1 |
C12orf5 | GLS | 0 | 0 | 391 | 438 | 2 | 1 |
C12orf5 | PIK3CA | 0 | 0 | 138 | 175 | 2 | 1 |
C12orf5 | ESR1 | 0 | 0 | 170 | 169 | 2 | 1 |
C12orf5 | UBQLN2 | 0 | 0 | 0 | 151 | 2 | 1 |
C12orf5 | MAP1LC3B | 0 | 0 | 181 | 215 | 2 | 1 |
C12orf5 | ULK1 | 0 | 0 | 184 | 235 | 2 | 1 |
C12orf5 | LDHA | 0 | 0 | 543 | 621 | 2 | 1 |
C12orf5 | AMBRA1 | 0 | 0 | 155 | 154 | 2 | 1 |
C12orf5 | TNFRSF10B | 0 | 0 | 171 | 171 | 2 | 1 |
C12orf5 | CASP3 | 0 | 0 | 260 | 276 | 2 | 1 |
C12orf5 | ATG16L1 | 0 | 0 | 134 | 164 | 2 | 1 |
C12orf5 | CDKN2A | 0 | 0 | 203 | 203 | 2 | 1 |
C12orf5 | KRAS | 0 | 0 | 294 | 333 | 2 | 1 |
C12orf5 | LPIN1 | 0 | 0 | 325 | 396 | 2 | 1 |
C12orf5 | BECN1 | 0 | 0 | 335 | 346 | 2 | 1 |
C12orf5 | AKT1 | 0 | 0 | 458 | 458 | 2 | 1 |
C12orf5 | IKBKB | 0 | 0 | 167 | 197 | 2 | 1 |
C12orf5 | ERBB2 | 0 | 0 | 184 | 183 | 2 | 1 |
C12orf5 | BBC3 | 0 | 0 | 361 | 361 | 2 | 1 |
C12orf5 | RAB25 | 0 | 0 | 113 | 155 | 2 | 1 |
C12orf5 | SRC | 0 | 0 | 202 | 202 | 2 | 1 |
C12orf5 | VHL | 0 | 0 | 171 | 171 | 2 | 1 |
C12orf5 | TOMM20 | 0 | 0 | 180 | 197 | 2 | 1 |
C12orf5 | EIF2S1 | 0 | 0 | 74 | 190 | 2 | 1 |
C12orf5 | BNIP3L | 0 | 0 | 298 | 298 | 2 | 1 |
C12orf5 | TSC2 | 271 | 0 | 381 | 529 | 2 | 1 |
C12orf5 | DDIT4 | 0 | 0 | 249 | 256 | 2 | 1 |
C12orf5 | CTLA4 | 0 | 0 | 55 | 151 | 2 | 1 |
C12orf5 | CAT | 0 | 0 | 226 | 354 | 2 | 1 |
C12orf5 | RPS6KB1 | 0 | 0 | 234 | 234 | 2 | 1 |
C12orf5 | DRAM1 | 0 | 0 | 518 | 518 | 2 | 1 |
C12orf5 | UVRAG | 0 | 0 | 161 | 164 | 2 | 1 |
C12orf5 | SLC7A11 | 0 | 0 | 300 | 304 | 2 | 1 |
C12orf5 | EEF2 | 0 | 0 | 0 | 166 | 2 | 1 |
C12orf5 | FIS1 | 0 | 0 | 124 | 156 | 2 | 1 |
C12orf5 | CYCS | 0 | 0 | 342 | 388 | 2 | 1 |
C12orf5 | EGF | 0 | 0 | 161 | 161 | 2 | 1 |
C12orf5 | SESN2 | 0 | 0 | 520 | 539 | 2 | 1 |
C12orf5 | GPX4 | 0 | 0 | 150 | 190 | 2 | 1 |
C12orf5 | SIRT6 | 0 | 0 | 267 | 299 | 2 | 1 |
C12orf5 | ECD | 0 | 0 | 123 | 258 | 2 | 1 |
C12orf5 | DBT | 0 | 0 | 0 | 167 | 2 | 1 |
C12orf5 | EP300 | 0 | 0 | 159 | 169 | 2 | 1 |
C12orf5 | CDK5 | 0 | 0 | 134 | 159 | 2 | 1 |
C12orf5 | DRAM2 | 0 | 0 | 57 | 220 | 2 | 1 |
C12orf5 | ATG13 | 0 | 0 | 118 | 158 | 2 | 1 |
C12orf5 | SQSTM1 | 0 | 0 | 213 | 213 | 2 | 1 |
C12orf5 | BNIP3 | 0 | 0 | 408 | 408 | 2 | 1 |
C12orf5 | HSP90AA1 | 0 | 0 | 123 | 207 | 2 | 1 |
C12orf5 | TP73 | 0 | 0 | 66 | 231 | 2 | 1 |
C12orf5 | ATG9A | 0 | 0 | 141 | 175 | 2 | 1 |
C12orf5 | CDKN1A | 0 | 0 | 325 | 329 | 2 | 1 |
C12orf5 | BID | 0 | 0 | 138 | 177 | 2 | 1 |
C12orf5 | BAX | 0 | 0 | 150 | 173 | 2 | 1 |
C12orf5 | MFN1 | 0 | 0 | 136 | 183 | 2 | 1 |
C12orf5 | ARNT | 0 | 0 | 261 | 261 | 2 | 1 |
C12orf5 | SOD1 | 0 | 0 | 108 | 183 | 2 | 1 |
C12orf5 | CYP19A1 | 0 | 0 | 141 | 151 | 2 | 1 |
C12orf5 | RELA | 0 | 0 | 122 | 204 | 2 | 1 |
C12orf5 | NFKB1 | 0 | 0 | 43 | 175 | 2 | 1 |
C12orf5 | GAPDH | 0 | 0 | 321 | 580 | 2 | 1 |
C12orf5 | PTBP1 | 0 | 0 | 113 | 150 | 2 | 1 |
C12orf5 | PFKFB3 | 0 | 900 | 606 | 969 | 2 | 1 |
C12orf5 | SIRT2 | 0 | 0 | 228 | 261 | 2 | 1 |
C12orf5 | MTOR | 0 | 0 | 390 | 399 | 2 | 1 |
C12orf5 | PIK3C3 | 0 | 0 | 145 | 180 | 2 | 1 |
C12orf5 | MFN2 | 0 | 0 | 180 | 197 | 2 | 1 |
C12orf5 | CTNNB1 | 0 | 0 | 194 | 237 | 2 | 1 |
C12orf5 | HRAS | 0 | 0 | 310 | 329 | 2 | 1 |
C12orf5 | APAF1 | 0 | 0 | 212 | 229 | 2 | 1 |
C12orf5 | RAB8A | 0 | 0 | 0 | 317 | 2 | 1 |
C12orf5 | TP53 | 273 | 900 | 703 | 977 | 2 | 1 |
C12orf5 | MDM2 | 0 | 0 | 520 | 533 | 2 | 1 |
C12orf5 | EGFR | 0 | 0 | 248 | 248 | 2 | 1 |
C12orf5 | SLC2A1 | 0 | 0 | 607 | 620 | 2 | 1 |
C12orf5 | NEDD8 | 0 | 0 | 0 | 183 | 2 | 1 |
C12orf5 | RB1CC1 | 0 | 0 | 218 | 218 | 2 | 1 |
C12orf5 | BRCA1 | 0 | 0 | 181 | 181 | 2 | 1 |
C12orf5 | STK11 | 0 | 0 | 367 | 404 | 2 | 1 |
C12orf5 | PPARGC1A | 0 | 0 | 358 | 358 | 2 | 1 |
C12orf5 | RAB13 | 0 | 0 | 0 | 317 | 2 | 1 |
C12orf5 | SIRT1 | 0 | 0 | 369 | 396 | 2 | 1 |
C12orf5 | MCL1 | 0 | 0 | 217 | 217 | 2 | 1 |
C12orf5 | HIPK2 | 0 | 0 | 150 | 259 | 2 | 1 |
C12orf5 | ATG5 | 0 | 0 | 295 | 295 | 2 | 1 |
C12orf5 | HSPB1 | 0 | 0 | 135 | 153 | 2 | 1 |
C12orf5 | ATG10 | 0 | 0 | 152 | 187 | 2 | 1 |
C12orf5 | ATM | 0 | 0 | 390 | 390 | 2 | 1 |
C12orf5 | NAMPT | 0 | 0 | 101 | 154 | 2 | 1 |
C12orf5 | ATG7 | 0 | 0 | 274 | 293 | 2 | 1 |
C12orf5 | DNM1L | 0 | 0 | 151 | 194 | 2 | 1 |
C12orf5 | PTEN | 0 | 0 | 451 | 463 | 2 | 1 |
C12orf5 | VEGFA | 0 | 0 | 202 | 202 | 2 | 1 |
C12orf5 | ATG12 | 0 | 0 | 204 | 204 | 2 | 1 |
C12orf5 | NQO1 | 0 | 0 | 181 | 181 | 2 | 1 |
C12orf5 | GPI | 0 | 0 | 320 | 682 | 2 | 1 |
C12orf5 | SFN | 0 | 0 | 219 | 236 | 2 | 1 |
C12orf5 | CUL3 | 0 | 0 | 142 | 171 | 2 | 1 |
C12orf5 | HSPA5 | 0 | 0 | 106 | 168 | 2 | 1 |
C12orf5 | SOD2 | 0 | 0 | 226 | 393 | 2 | 1 |
C12orf5 | FOXO1 | 0 | 0 | 161 | 161 | 2 | 1 |
C12orf5 | MET | 0 | 0 | 194 | 194 | 2 | 1 |
C12orf5 | LRRK2 | 270 | 0 | 42 | 286 | 2 | 1 |
C12orf5 | PMAIP1 | 0 | 0 | 493 | 500 | 2 | 1 |
C12orf5 | DLD | 0 | 0 | 107 | 281 | 2 | 1 |
C12orf5 | EIF4EBP1 | 0 | 0 | 210 | 210 | 2 | 1 |
C12orf5 | PINK1 | 0 | 0 | 195 | 195 | 2 | 1 |
C12orf5 | FOXO3 | 0 | 0 | 247 | 246 | 2 | 1 |
C12orf5 | TP53INP1 | 0 | 0 | 322 | 321 | 2 | 1 |
C12orf5 | ATG3 | 0 | 0 | 134 | 186 | 2 | 1 |
C12orf5 | VDAC1 | 0 | 0 | 263 | 279 | 2 | 1 |
C12orf5 | RHEB | 0 | 0 | 223 | 246 | 2 | 1 |
C12orf5 | TP53INP2 | 0 | 0 | 123 | 161 | 2 | 1 |
C12orf5 | CCND1 | 0 | 0 | 171 | 272 | 2 | 1 |
C12orf5 | PRKAA1 | 0 | 0 | 180 | 321 | 2 | 1 |
C12orf5 | NOS3 | 0 | 0 | 113 | 190 | 2 | 1 |
C12orf5 | FAU | 0 | 0 | 0 | 187 | 2 | 1 |
C12orf5 | IGF1 | 0 | 0 | 155 | 155 | 2 | 1 |
ID | Category | Term | Effect | Evidence | PubMed |
---|---|---|---|---|---|
GO:0004331 | Molecular Function | fructose-2,6-bisphosphate 2-phosphatase activity | enables | EXP | |
GO:0004331 | Molecular Function | fructose-2,6-bisphosphate 2-phosphatase activity | enables | IBA | |
GO:0004331 | Molecular Function | fructose-2,6-bisphosphate 2-phosphatase activity | enables | IDA | |
GO:0005515 | Molecular Function | protein binding | enables | IPI | |
GO:0006974 | Biological Process | DNA damage response | involved_in | IDA | |
GO:0010659 | Biological Process | cardiac muscle cell apoptotic process | involved_in | IEA | |
GO:0071279 | Biological Process | cellular response to cobalt ion | involved_in | IDA | |
GO:0071456 | Biological Process | cellular response to hypoxia | involved_in | IDA | |
GO:0006003 | Biological Process | fructose 2,6-bisphosphate metabolic process | involved_in | IEA | |
GO:0019661 | Biological Process | glucose catabolic process to lactate via pyruvate | involved_in | IEA | |
GO:0006096 | Biological Process | glycolytic process | involved_in | IEA | |
GO:0060576 | Biological Process | intestinal epithelial cell development | involved_in | IEA | |
GO:0000423 | Biological Process | mitophagy | involved_in | IEA | |
GO:1904024 | Biological Process | negative regulation of glucose catabolic process to lactate via pyruvate | involved_in | IEA | |
GO:0045820 | Biological Process | negative regulation of glycolytic process | involved_in | IBA | |
GO:1901525 | Biological Process | negative regulation of mitophagy | involved_in | IEA | |
GO:0043069 | Biological Process | negative regulation of programmed cell death | involved_in | IDA | |
GO:2000378 | Biological Process | negative regulation of reactive oxygen species metabolic process | involved_in | IEA | |
GO:0045739 | Biological Process | positive regulation of DNA repair | involved_in | IMP | |
GO:0010666 | Biological Process | positive regulation of cardiac muscle cell apoptotic process | involved_in | IEA | |
GO:1903301 | Biological Process | positive regulation of hexokinase activity | involved_in | IDA | |
GO:1905857 | Biological Process | positive regulation of pentose-phosphate shunt | involved_in | IEA | |
GO:0072593 | Biological Process | reactive oxygen species metabolic process | involved_in | IEA | |
GO:0043456 | Biological Process | regulation of pentose-phosphate shunt | involved_in | IBA | |
GO:0043456 | Biological Process | regulation of pentose-phosphate shunt | involved_in | IMP | |
GO:1902153 | Biological Process | regulation of response to DNA damage checkpoint signaling | involved_in | IMP | |
GO:0010332 | Biological Process | response to gamma radiation | involved_in | IEA | |
GO:0002931 | Biological Process | response to ischemia | involved_in | ISS | |
GO:0009410 | Biological Process | response to xenobiotic stimulus | involved_in | IEA | |
GO:0005737 | Cellular Component | cytoplasm | located_in | IDA | |
GO:0005829 | Cellular Component | cytosol | is_active_in | IBA | |
GO:0005829 | Cellular Component | cytosol | located_in | IDA | |
GO:0005829 | Cellular Component | cytosol | located_in | TAS | |
GO:0005741 | Cellular Component | mitochondrial outer membrane | located_in | IDA | |
GO:0005634 | Cellular Component | nucleus | located_in | IDA |
Name | DB | ID |
---|---|---|
Generic Transcription Pathway | Reactome | R-HSA-212436 |
Transcriptional Regulation by TP53 | Reactome | R-HSA-3700989 |
TP53 Regulates Metabolic Genes | Reactome | R-HSA-5628897 |
RNA Polymerase II Transcription | Reactome | R-HSA-73857 |
Gene expression (Transcription) | Reactome | R-HSA-74160 |
p53 transcriptional gene network (WP4963) | WikiPathways | WP4963_r122690 |
Metabolic reprogramming in colon cancer (WP4290) | WikiPathways | WP4290_r118611 |