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MCOLN1

mucolipin TRP cation channel 1
General Information
Name mucolipin TRP cation channel 1
Alias
  • mucolipin-1
  • mucolipidin
  • mucolipidosis type IV protein
  • mucolipin 1
  • transient receptor potential cation channel mucolipin subfamily member 1
  • transient receptor potential channel mucolipin 1
  • transient receptor potential mucolipin 1
Gene_family Transient receptor potential cation channels
organism Homo sapiens
entrez_id 57192
location 19p13.2
transcript_count 1
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]
    Stringdb Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By simil [...]
    nextProt May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MCOLN1 BioGRID ORF3a GeneID BioGRID Proximity Label-MS
MCOLN1 BioGRID MCOLN2 GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID ILRUN GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID SPPL2B GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID CSGALNACT2 GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID MCOLN3 GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID CLEC2B GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID LY6D GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID TPST2 GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID CCR6 GeneID BioGRID Affinity Capture-MS
MCOLN1 BioGRID ATG10 GeneID BioGRID Phenotypic Enhancement
MCOLN1 BioGRID ATG3 GeneID BioGRID Phenotypic Enhancement
MCOLN1 BioGRID PTP4A3 GeneID BioGRID Phenotypic Suppression
MCOLN1 BioGRID GPR35 GeneID BioGRID Two-hybrid
MCOLN1 BioGRID SEC22A GeneID BioGRID Two-hybrid
MCOLN1 BioGRID APPBP2 GeneID BioGRID Two-hybrid
MCOLN1 BioGRID VDAC2 GeneID BioGRID Co-fractionation
MCOLN1 Protein TRIM27 GeneID HPRD
MCOLN1 Protein SLC35E1 GeneID HPRD
MCOLN1 BioGRID SLC35E1 GeneID BioGRID Two-hybrid
MCOLN1 BioGRID TRIM27 GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
MCOLN1 DNAJB1 0 0 691 691 1 2
MCOLN1 ATG3 0 0 137 165 1 2
MCOLN1 HARS2 0 0 75 410 1 1
MCOLN1 JDP2 0 0 57 154 1 1
MCOLN1 PKD1 0 0 561 655 1 1
MCOLN1 SYT3 0 0 180 179 1 1
MCOLN1 NAGLU 0 0 233 259 1 1
MCOLN1 TXNDC9 0 0 52 397 1 1
MCOLN1 ADA 0 0 128 300 1 1
MCOLN1 ORAI2 0 0 180 263 1 1
MCOLN1 CHST5 0 0 0 239 1 1
MCOLN1 PQLC2 0 0 236 262 1 1
MCOLN1 AP3M1 0 0 138 230 1 1
MCOLN1 ENSG00000279890 0 0 73 173 1 1
MCOLN1 EEA1 0 0 341 375 1 2
MCOLN1 MCU 0 0 320 319 1 2
MCOLN1 TRPV2 0 0 560 587 1 1
MCOLN1 ZFYVE1 0 0 123 179 1 2
MCOLN1 GRM6 0 0 156 155 1 1
MCOLN1 TRPV4 0 0 542 570 1 1
MCOLN1 BET1L 0 0 120 276 1 1
MCOLN1 PITPNB 0 0 108 311 1 1
MCOLN1 VAMP7 0 0 439 439 1 2
MCOLN1 SBF2 0 0 86 160 1 1
MCOLN1 CLCN7 0 0 561 662 1 1
MCOLN1 ALG2 0 0 142 343 1 1
MCOLN1 SLC30A2 0 0 340 350 1 1
MCOLN1 TGFB1 0 0 0 187 1 2
MCOLN1 VDAC1 0 0 335 335 1 2
MCOLN1 TSC2 0 0 135 153 1 2
MCOLN1 RAB7B 0 0 450 507 1 1
MCOLN1 STX17 0 0 144 229 1 2
MCOLN1 POC1B-GALNT4 0 0 0 190 1 1
MCOLN1 RAB11A 0 0 142 177 1 2
MCOLN1 MITF 0 0 260 306 1 2
MCOLN1 RRAGA 0 0 193 352 1 1
MCOLN1 CCZ1 0 0 75 157 1 1
MCOLN1 LAPTM4B 0 0 167 483 1 2
MCOLN1 HMOX1 0 0 134 193 1 2
MCOLN1 TMEM185B 0 0 155 238 1 1
MCOLN1 CACNA1A 0 0 240 239 1 1
MCOLN1 SEC13 0 0 456 456 1 1
MCOLN1 GALNT6 0 0 82 485 1 1
MCOLN1 CHST15 0 0 81 561 1 1
MCOLN1 PCBP4 0 0 74 173 1 1
MCOLN1 SPTB 0 0 204 204 1 1
MCOLN1 SLC36A1 0 0 203 203 1 1
MCOLN1 PANX1 0 0 134 170 1 1
MCOLN1 SWAP70 0 0 64 166 1 1
MCOLN1 LETM1 0 0 108 349 1 1
MCOLN1 SYT14 0 0 181 181 1 1
MCOLN1 SLC30A5 0 0 64 278 1 1
MCOLN1 ATP2A3 0 0 108 169 1 1
MCOLN1 DYSF 0 0 113 226 1 1
MCOLN1 AKT1 0 0 217 217 1 2
MCOLN1 AP2M1 0 0 76 211 1 1
MCOLN1 LETM2 0 0 134 423 1 1
MCOLN1 CTSC 0 0 294 326 1 1
MCOLN1 CCZ1B 0 0 75 157 1 1
MCOLN1 LOC102724488 0 0 184 183 1 1
MCOLN1 SLIT3 0 0 0 190 1 1
MCOLN1 YME1L1 0 0 0 538 1 1
MCOLN1 TMEM163 0 0 469 768 1 1
MCOLN1 TGFBI 0 0 107 257 1 1
MCOLN1 IGF2R 0 0 139 189 1 1
MCOLN1 TPM3 0 0 488 487 1 1
MCOLN1 PKD2 0 0 622 703 1 2
MCOLN1 FBN1 0 0 457 457 1 1
MCOLN1 ATP6V1A 0 0 160 210 1 1
MCOLN1 ANK3 0 0 0 188 1 1
MCOLN1 EIF4EBP1 0 0 154 155 1 2
MCOLN1 PIKFYVE 0 0 764 820 1 2
MCOLN1 EHD1 0 0 0 183 1 1
MCOLN1 MYOF 0 0 49 151 1 1
MCOLN1 SLC12A6 0 0 155 241 1 1
MCOLN1 PAGE1 0 0 182 181 1 1
MCOLN1 PPP3CA 0 0 90 173 1 1
MCOLN1 GALNT12 0 0 83 525 1 1
MCOLN1 PINK1 0 0 172 228 1 2
MCOLN1 UVRAG 0 0 391 404 1 2
MCOLN1 WDFY3 0 0 94 176 1 2
MCOLN1 MAPK1 0 0 144 215 1 2
MCOLN1 WDR45 0 0 165 190 1 2
MCOLN1 KCNG2 0 0 107 168 1 1
MCOLN1 RPS10 0 0 0 175 1 1
MCOLN1 UBXN6 0 0 0 318 1 1
MCOLN1 APBA1 0 0 53 211 1 1
MCOLN1 TMEM55A 0 0 154 496 1 1
MCOLN1 RAB7A 0 0 459 614 1 2
MCOLN1 TFRC 0 0 270 276 1 1
MCOLN1 FLVCR1 0 0 172 255 1 1
MCOLN1 CD63 0 0 517 527 1 2
MCOLN1 IREB2 0 0 134 165 1 1
MCOLN1 ATP12A 0 0 293 294 1 1
MCOLN1 AP2A2 0 0 103 176 1 1
MCOLN1 ABCA2 0 0 60 158 1 1
MCOLN1 FNIP2 0 0 134 166 1 1
MCOLN1 TRPM1 0 0 664 737 1 1
MCOLN1 ZFYVE26 0 0 156 155 1 1
MCOLN1 SMPD2 0 0 136 169 1 1
MCOLN1 NME1 0 0 454 461 1 1
MCOLN1 ATP13A2 0 0 336 436 1 1
MCOLN1 ETV3 0 0 0 189 1 1
MCOLN1 PNPLA6 0 0 721 749 1 1
MCOLN1 ERV3-1 0 0 400 400 1 1
MCOLN1 WIPI2 0 0 224 255 1 2
MCOLN1 CLEC10A 0 0 423 422 1 1
MCOLN1 VPS36 0 0 0 189 1 1
MCOLN1 SYT10 0 0 180 179 1 1
MCOLN1 STAG1 0 0 154 339 1 1
MCOLN1 SYT16 0 0 186 186 1 1
MCOLN1 VPS51 0 0 0 160 1 1
MCOLN1 STK32C 0 0 134 226 1 1
MCOLN1 VPS11 0 0 181 279 1 1
MCOLN1 ANK2 0 0 0 188 1 1
MCOLN1 AKAP17A 0 0 0 540 1 1
MCOLN1 SLC39A8 0 0 244 243 1 1
MCOLN1 AP2B1 0 0 108 156 1 1
MCOLN1 SLC17A5 0 0 194 699 1 1
MCOLN1 HPRT1 0 0 155 154 1 1
MCOLN1 DNAJC14 0 0 0 209 1 1
MCOLN1 RHEB 0 0 235 334 1 2
MCOLN1 CD38 0 0 112 173 1 2
MCOLN1 SIDT1 0 0 0 422 1 1
MCOLN1 ANXA7 0 0 134 156 1 1
MCOLN1 SLC7A13 0 0 130 153 1 1
MCOLN1 GBA 0 0 323 377 1 1
MCOLN1 ATP2A2 0 0 108 160 1 1
MCOLN1 KLF9 0 0 0 189 1 1
MCOLN1 RAB34 0 0 134 272 1 1
MCOLN1 ZNF438 0 0 155 154 1 1
MCOLN1 PRKAA1 0 0 66 154 1 2
MCOLN1 ENSG00000257390 0 0 0 209 1 1
MCOLN1 SPTLC2 0 0 60 423 1 1
MCOLN1 SNRNP48 0 0 0 248 1 1
MCOLN1 ALG12 0 0 96 569 1 1
MCOLN1 STIM1 0 0 358 422 1 2
MCOLN1 LIPA 0 0 230 229 1 1
MCOLN1 ZNF235 0 0 0 208 1 1
MCOLN1 EHD3 0 0 87 223 1 1
MCOLN1 OR52E8 0 0 256 256 1 1
MCOLN1 RPS6KB1 0 0 193 193 1 2
MCOLN1 SPG11 0 0 205 205 1 1
MCOLN1 ATP6V0A1 0 0 216 251 1 1
MCOLN1 PPP3R1 0 0 53 151 1 1
MCOLN1 B4GALT1 0 0 56 313 1 1
MCOLN1 NR1H4 0 0 61 221 1 1
MCOLN1 ATG7 0 0 263 276 1 2
MCOLN1 KIAA1210 0 0 0 187 1 1
MCOLN1 SYT2 0 0 155 154 1 1
MCOLN1 KCNA2 0 0 154 154 1 1
MCOLN1 CLCN3 0 0 204 273 1 1
MCOLN1 VTI1B 0 0 216 272 1 2
MCOLN1 M6PR 0 0 241 240 1 1
MCOLN1 KCNK2 0 0 182 181 1 1
MCOLN1 CTSD 0 0 460 536 1 2
MCOLN1 SARNP 0 0 0 205 1 1
MCOLN1 AP2A1 0 0 81 157 1 1
MCOLN1 ABCB7 0 0 216 221 1 1
MCOLN1 MGEA5 0 0 256 256 1 1
MCOLN1 CLN6 0 0 171 178 1 1
MCOLN1 SYT5 0 0 172 171 1 1
MCOLN1 STEAP1 0 0 181 182 1 1
MCOLN1 PKD2L1 0 0 602 688 1 1
MCOLN1 AMBRA1 0 0 171 205 1 2
MCOLN1 PRKAA2 0 0 94 179 1 2
MCOLN1 SLC39A14 0 0 294 306 1 1
MCOLN1 NAGPA 0 0 82 163 1 1
MCOLN1 WIPI1 0 0 322 349 1 2
MCOLN1 AP4B1 0 0 103 200 1 1
MCOLN1 RRAGB 0 0 266 410 1 1
MCOLN1 PI4KB 0 0 158 215 1 1
MCOLN1 NOSTRIN 0 0 90 226 1 1
MCOLN1 FTL 0 0 154 153 1 1
MCOLN1 TRPV3 0 0 509 539 1 1
MCOLN1 GABARAP 0 0 181 269 1 2
MCOLN1 ENSG00000241489 0 0 0 392 1 1
MCOLN1 ATP4A 0 0 295 303 1 1
MCOLN1 ARSK 0 0 140 584 1 1
MCOLN1 PLEKHM2 0 0 126 157 1 1
MCOLN1 CAPNS1 0 0 108 376 1 2
MCOLN1 STPG1 0 0 193 193 1 1
MCOLN1 PRKD1 0 0 134 166 1 1
MCOLN1 ATG5 0 0 324 325 1 2
MCOLN1 LAPTM5 0 0 424 437 1 1
MCOLN1 SLC17A2 0 0 0 214 1 1
MCOLN1 PPT1 0 0 140 159 1 1
MCOLN1 PLEKHA2 0 0 210 421 1 1
MCOLN1 OPTN 0 0 129 183 1 2
MCOLN1 TMEM55B 0 0 392 433 1 1
MCOLN1 TRPA1 0 0 561 661 1 1
MCOLN1 BACE1 0 0 109 175 1 2
MCOLN1 TRAPPC5 0 0 0 302 1 1
MCOLN1 TLE3 0 0 71 229 1 1
MCOLN1 CTSB 0 0 420 457 1 2
MCOLN1 PCBP3 0 0 107 244 1 1
MCOLN1 ANO5 0 0 122 216 1 1
MCOLN1 GEM 0 0 128 151 1 1
MCOLN1 PCBP1 0 0 143 275 1 1
MCOLN1 AP2S1 0 0 88 202 1 1
MCOLN1 FNIP1 0 0 171 193 1 1
MCOLN1 TBP 0 0 82 241 1 1
MCOLN1 ULK1 0 0 270 270 1 2
MCOLN1 ATP6AP1 0 0 150 255 1 1
MCOLN1 GNPTG 0 0 151 150 1 1
MCOLN1 MAP3K12 0 0 53 311 1 1
MCOLN1 SLC24A5 0 0 113 206 1 1
MCOLN1 HMOX2 0 0 96 424 1 1
MCOLN1 VPS33B 0 0 74 191 1 1
MCOLN1 MAP1LC3B 0 0 391 413 1 2
MCOLN1 SURF2 0 0 61 155 1 1
MCOLN1 GLI1 0 0 0 189 1 2
MCOLN1 CHST6 0 0 108 293 1 1
MCOLN1 PACSIN3 0 0 135 170 1 1
MCOLN1 ATG10 0 0 157 156 1 2
MCOLN1 ESPN 0 0 73 216 1 1
MCOLN1 TSG101 0 0 143 166 1 2
MCOLN1 RHOD 0 0 0 188 1 1
MCOLN1 MON1A 0 0 84 231 1 1
MCOLN1 YWHAZ 0 0 0 302 1 1
MCOLN1 TBC1D2B 0 0 0 157 1 1
MCOLN1 FOS 0 0 72 161 1 2
MCOLN1 EXPH5 0 0 95 234 1 1
MCOLN1 TMPRSS4 0 0 75 365 1 1
MCOLN1 GALNT2 0 0 62 533 1 1
MCOLN1 RRAGC 0 0 243 242 1 1
MCOLN1 SERHL2 0 0 0 535 1 1
MCOLN1 SNX2 0 0 218 281 1 1
MCOLN1 FTH1 0 0 193 203 1 1
MCOLN1 TFE3 0 0 517 591 1 2
MCOLN1 HSPA5 0 0 330 330 1 2
MCOLN1 NPHP1 0 0 0 163 1 1
MCOLN1 DNAJC13 0 0 245 450 1 1
MCOLN1 ARL4C 0 0 82 237 1 1
MCOLN1 ATP6V0E1 0 0 294 402 1 1
MCOLN1 LRP1 0 0 132 151 1 1
MCOLN1 SNAPIN 0 0 128 193 1 1
MCOLN1 ARF6 0 0 389 425 1 1
MCOLN1 PEX16 0 0 77 151 1 1
MCOLN1 NAPA 0 0 0 156 1 1
MCOLN1 AP1S1 0 0 181 241 1 1
MCOLN1 BECN1 0 0 394 421 1 2
MCOLN1 ERF 0 0 62 318 1 1
MCOLN1 TOLLIP 0 0 87 152 1 1
MCOLN1 ELAVL4 0 0 108 169 1 1
MCOLN1 LRRK2 0 0 246 250 1 2
MCOLN1 ORAI3 0 0 146 233 1 1
MCOLN1 DNAJC10 0 0 66 164 1 1
MCOLN1 HPS4 0 0 83 171 1 1
MCOLN1 LRP2 0 0 141 180 1 1
MCOLN1 VAC14 0 0 505 551 1 1
MCOLN1 RBM22 0 0 125 159 1 1
MCOLN1 SLC48A1 0 0 219 328 1 1
MCOLN1 ENSG00000260914 0 0 0 211 1 1
MCOLN1 ITPKA 0 0 73 215 1 1
MCOLN1 CLCN6 0 0 97 260 1 1
MCOLN1 FRMD6 0 0 816 816 1 1
MCOLN1 SLC40A1 0 0 108 198 1 1
MCOLN1 RRAGD 0 0 211 211 1 1
MCOLN1 KCNJ15 0 0 134 188 1 1
MCOLN1 MRPL30 0 0 0 177 1 1
MCOLN1 BIN2 0 0 107 197 1 1
MCOLN1 PLEKHM1 0 0 134 169 1 1
MCOLN1 ATG101 0 0 123 177 1 2
MCOLN1 HSPA1B 0 0 0 298 1 1
MCOLN1 PLA2G7 0 0 81 263 1 1
MCOLN1 TRPM2 0 0 470 586 1 2
MCOLN1 SLC25A16 0 0 246 245 1 1
MCOLN1 GAPVD1 0 0 0 166 1 1
MCOLN1 RPS10-NUDT3 0 0 0 175 1 1
MCOLN1 CASP3 0 0 143 169 1 2
MCOLN1 SIDT2 0 0 146 664 1 1
MCOLN1 ATP6V1B2 0 0 131 157 1 1
MCOLN1 ATG12 0 0 241 266 1 2
MCOLN1 EHD2 0 0 107 201 1 1
MCOLN1 ASAH1 0 0 113 154 1 1
MCOLN1 USH1C 0 0 192 698 1 1
MCOLN1 ENSG00000273155 0 0 0 489 1 1
MCOLN1 C10orf32 0 0 161 161 1 1
MCOLN1 TRPC4 0 0 505 557 1 1
MCOLN1 CDC34 0 0 0 171 1 1
MCOLN1 SLC11A1 0 0 213 308 1 1
MCOLN1 KCNQ2 0 0 180 191 1 1
MCOLN1 NUDT9 0 0 204 285 1 1
MCOLN1 HPX 0 0 154 179 1 1
MCOLN1 ST3GAL5 0 0 71 449 1 1
MCOLN1 UNC119 0 0 123 163 1 1
MCOLN1 TRPM3 0 0 520 625 1 1
MCOLN1 RBL2 0 0 54 311 1 1
MCOLN1 MRPL36 0 0 96 302 1 1
MCOLN1 ATP6V1C1 0 0 218 320 1 1
MCOLN1 SESTD1 0 0 141 201 1 1
MCOLN1 ATG16L1 0 0 213 229 1 2
MCOLN1 CSGALNACT2 183 0 0 183 1 1
MCOLN1 SMPD1 0 0 420 432 1 1
MCOLN1 NEU3 0 0 764 764 1 1
MCOLN1 IDS 0 0 0 392 1 1
MCOLN1 SLC30A4 0 0 316 315 1 1
MCOLN1 KCNJ10 0 0 539 539 1 1
MCOLN1 ACO1 0 0 160 181 1 1
MCOLN1 TRPV5 0 0 561 636 1 1
MCOLN1 LAMTOR1 0 0 171 171 1 1
MCOLN1 HPSE2 0 0 0 244 1 1
MCOLN1 NALCN 0 0 193 229 1 1
MCOLN1 PIK3C3 0 0 382 398 1 2
MCOLN1 CHMP2B 0 0 162 161 1 2
MCOLN1 CATSPER1 0 0 217 217 1 1
MCOLN1 PLEK 0 0 151 169 1 1
MCOLN1 KCNMA1 0 0 436 462 1 1
MCOLN1 VPS4A 0 0 60 226 1 1
MCOLN1 SCPEP1 0 0 97 153 1 1
MCOLN1 MAN2C1 0 0 103 496 1 1
MCOLN1 PSEN2 0 0 141 235 1 1
MCOLN1 EVI5L 0 0 0 420 1 1
MCOLN1 PLSCR3 0 0 252 266 1 1
MCOLN1 ADAR 0 0 0 303 1 1
MCOLN1 MTMR3 0 0 120 202 1 2
MCOLN1 SORT1 0 0 112 152 1 1
MCOLN1 ANXA11 0 0 150 173 1 1
MCOLN1 DCTN2 0 0 421 421 1 1
MCOLN1 ARSH 0 0 149 210 1 1
MCOLN1 TRPV6 0 0 562 636 1 1
MCOLN1 MTOR 0 0 391 390 1 2
MCOLN1 SYT7 0 0 464 500 1 1
MCOLN1 AP1B1 0 0 90 173 1 1
MCOLN1 GLA 0 0 147 205 1 2
MCOLN1 TRPV1 0 0 600 625 1 2
MCOLN1 GANAB 0 0 0 223 1 1
MCOLN1 ARL8A 0 0 0 216 1 1
MCOLN1 APP 0 0 241 246 1 2
MCOLN1 MFN2 0 0 233 248 1 2
MCOLN1 MAP1LC3A 0 0 480 483 1 2
MCOLN1 OSTM1 0 0 291 305 1 1
MCOLN1 CACNA2D2 0 0 76 173 1 1
MCOLN1 RAB5A 0 0 350 422 1 2
MCOLN1 RAB5B 0 0 54 159 1 1
MCOLN1 PKD1L1 0 0 223 307 1 1
MCOLN1 ATP6V1H 0 0 359 446 1 1
MCOLN1 PRKCB 0 0 180 179 1 2
MCOLN1 TRPM7 0 0 603 690 1 1
MCOLN1 CTSL 0 0 188 189 1 2
MCOLN1 CLN3 0 0 340 641 1 2
MCOLN1 UNC79 0 0 96 158 1 1
MCOLN1 GAPDH 0 0 260 266 1 2
MCOLN1 SLC39A9 0 0 136 190 1 1
MCOLN1 TRPC3 0 0 561 607 1 1
MCOLN1 ATG14 0 0 260 280 1 2
MCOLN1 SYT15 0 0 184 183 1 1
MCOLN1 GALNT4 0 0 107 245 1 1
MCOLN1 GABARAPL2 0 0 212 266 1 2
MCOLN1 ARL5B 0 0 249 286 1 1
MCOLN1 HAMP 0 0 120 175 1 1
MCOLN1 PGLYRP2 0 0 74 326 1 1
MCOLN1 ITPR2 0 0 161 220 1 1
MCOLN1 EVI5 0 0 0 420 1 1
MCOLN1 PIK3R4 0 0 203 203 1 2
MCOLN1 TPCN1 0 0 680 694 1 1
MCOLN1 FYCO1 0 0 270 270 1 2
MCOLN1 TRIM72 0 0 141 178 1 1
MCOLN1 POGK 0 0 0 463 1 1
MCOLN1 SLC38A9 0 0 209 209 1 1
MCOLN1 AP3B1 0 0 73 218 1 1
MCOLN1 TRPC1 0 0 653 689 1 1
MCOLN1 RYR3 0 0 240 283 1 1
MCOLN1 TEF 0 0 61 205 1 1
MCOLN1 IST1 0 0 73 206 1 1
MCOLN1 SCNN1D 0 0 0 188 1 1
MCOLN1 ZKSCAN3 0 0 369 392 1 2
MCOLN1 NSG1 0 0 117 318 1 1
MCOLN1 FIG4 0 0 517 600 1 1
MCOLN1 ARF1 0 0 389 399 1 1
MCOLN1 HSPA1L 0 0 126 282 1 1
MCOLN1 RYR2 0 0 205 289 1 1
MCOLN1 TPCN2 0 0 808 843 1 1
MCOLN1 HAVCR1 0 0 0 169 1 1
MCOLN1 PIEZO2 0 0 134 157 1 1
MCOLN1 STAG2 0 0 50 195 1 1
MCOLN1 SYT12 0 0 155 154 1 1
MCOLN1 GAST 0 0 626 626 1 1
MCOLN1 ARSD 0 0 92 157 1 1
MCOLN1 KIF20B 0 0 71 289 1 1
MCOLN1 MTMR2 0 0 233 263 1 1
MCOLN1 RB1CC1 0 0 170 175 1 2
MCOLN1 SLC30A3 0 0 241 252 1 1
MCOLN1 SYNJ1 0 0 157 156 1 1
MCOLN1 SYT13 0 0 180 179 1 1
MCOLN1 CNGB1 0 0 181 181 1 1
MCOLN1 VCX 0 0 152 151 1 1
MCOLN1 CIDEB 0 0 173 173 1 1
MCOLN1 EIF5B 0 0 0 306 1 1
MCOLN1 TFEC 0 0 348 354 1 1
MCOLN1 CMIP 0 0 74 159 1 1
MCOLN1 SUCO 0 0 46 306 1 1
MCOLN1 SYT8 0 0 181 181 1 1
MCOLN1 EFNA5 0 0 242 241 1 1
MCOLN1 TFR2 0 0 189 200 1 1
MCOLN1 VPS39 0 0 123 234 1 1
MCOLN1 HS6ST1 0 0 112 202 1 1
MCOLN1 NPC1 0 0 460 489 1 2
MCOLN1 PPP3CB 0 0 218 252 1 1
MCOLN1 GALNS 0 0 209 542 1 1
MCOLN1 TMBIM6 0 0 181 181 1 1
MCOLN1 LMBRD1 0 0 103 182 1 1
MCOLN1 STOML1 0 0 617 625 1 1
MCOLN1 ENSG00000261832 0 0 321 616 1 1
MCOLN1 AP4S1 0 0 114 249 1 1
MCOLN1 MICU1 0 0 195 231 1 1
MCOLN1 GAB2 0 0 0 151 1 1
MCOLN1 SYT11 0 0 181 181 1 1
MCOLN1 STEAP3 0 0 241 262 1 1
MCOLN1 DDX47 0 0 90 174 1 1
MCOLN1 SYT17 0 0 181 181 1 1
MCOLN1 DIRC2 0 0 66 162 1 1
MCOLN1 TMEM192 0 0 269 269 1 1
MCOLN1 PPRC1 0 0 72 348 1 1
MCOLN1 GNS 0 0 123 184 1 1
MCOLN1 ARL8B 0 0 266 399 1 1
MCOLN1 TMEM121 0 0 0 489 1 1
MCOLN1 SNAPC1 0 0 0 189 1 1
MCOLN1 HPSE 0 0 70 267 1 1
MCOLN1 PPARGC1A 0 0 181 199 1 2
MCOLN1 MTF1 0 0 157 156 1 1
MCOLN1 SCARB2 0 0 244 401 1 1
MCOLN1 SPATA31A3 0 0 171 171 1 1
MCOLN1 EXT1 0 0 62 205 1 1
MCOLN1 OCRL 270 0 218 448 1 1
MCOLN1 RPN1 0 0 450 450 1 1
MCOLN1 XRCC6 0 0 195 195 1 1
MCOLN1 TRIM23 0 0 0 157 1 1
MCOLN1 CYBRD1 0 0 286 300 1 1
MCOLN1 ATP6V0D1 0 0 195 369 1 1
MCOLN1 ETNK1 0 0 155 241 1 1
MCOLN1 CLCN5 0 0 82 171 1 1
MCOLN1 ARSB 0 0 243 359 1 2
MCOLN1 DLGAP1 0 0 57 213 1 1
MCOLN1 PDCD6 0 0 956 956 1 1
MCOLN1 HDAC6 0 0 54 153 1 2
MCOLN1 HGS 0 0 81 170 1 2
MCOLN1 CAMKK2 0 0 161 161 1 2
MCOLN1 PTPRD 0 0 54 159 1 1
MCOLN1 P2RX4 0 0 450 462 1 1
MCOLN1 SUMF1 0 0 233 338 1 1
MCOLN1 VPS4B 0 0 134 287 1 1
MCOLN1 RAB10 0 0 181 198 1 1
MCOLN1 ORAI1 0 0 325 350 1 1
MCOLN1 MYL6 0 0 447 447 1 1
MCOLN1 CTSA 0 0 282 355 1 1
MCOLN1 CAPNS2 0 0 0 217 1 1
MCOLN1 NGEF 0 0 60 162 1 1
MCOLN1 SLC7A5 0 0 69 379 1 1
MCOLN1 RNF10 0 0 0 151 1 1
MCOLN1 CFTR 0 0 185 211 1 2
MCOLN1 YIF1A 0 0 218 228 1 1
MCOLN1 ATP6V0C 0 0 193 322 1 1
MCOLN1 AP3D1 0 0 171 246 1 1
MCOLN1 HN1 0 0 113 502 1 1
MCOLN1 HTT 0 0 219 224 1 2
MCOLN1 MAP3K13 0 0 0 227 1 1
MCOLN1 VPS53 0 0 0 156 1 1
MCOLN1 STAU1 0 0 66 162 1 1
MCOLN1 ANKFY1 0 0 92 231 1 1
MCOLN1 LAMP1 0 0 607 646 1 2
MCOLN1 FFAR1 0 0 0 175 1 1
MCOLN1 LGALS4 0 0 161 161 1 1
MCOLN1 GLB1 0 0 116 215 1 1
MCOLN1 TBC1D2 0 0 0 157 1 1
MCOLN1 FECH 0 0 142 175 1 1
MCOLN1 ABCC8 0 0 95 175 1 1
MCOLN1 MARCH2 0 0 0 151 1 1
MCOLN1 DNM2 0 0 108 210 1 1
MCOLN1 SYT9 0 0 181 181 1 1
MCOLN1 GLI2 0 0 0 239 1 2
MCOLN1 MB21D1 0 0 0 189 1 1
MCOLN1 RAB32 0 0 0 216 1 2
MCOLN1 RYR1 0 0 285 326 1 2
MCOLN1 SCARA5 0 0 108 202 1 1
MCOLN1 NCF4 0 0 167 185 1 1
MCOLN1 CLCN1 0 0 123 166 1 1
MCOLN1 VPS35 0 0 171 225 1 2
MCOLN1 PKD1L2 0 0 72 172 1 1
MCOLN1 AP1M1 0 0 75 154 1 1
MCOLN1 IL4 0 0 0 212 1 1
MCOLN1 SLC22A17 0 0 155 173 1 1
MCOLN1 ADIPOR1 0 0 0 151 1 1
MCOLN1 SLC30A1 0 0 165 165 1 1
MCOLN1 F7 0 0 134 175 1 1
MCOLN1 PDGFRB 0 0 322 321 1 2
MCOLN1 HVCN1 0 0 292 301 1 1
MCOLN1 MITD1 0 0 0 538 1 1
MCOLN1 ABCC4 0 0 96 158 1 1
MCOLN1 TRPM4 0 0 565 631 1 1
MCOLN1 ALB 0 0 210 238 1 2
MCOLN1 NAPB 0 0 156 376 1 1
MCOLN1 SLC25A37 0 0 154 155 1 1
MCOLN1 IDO1 0 0 0 237 1 1
MCOLN1 CTNS 0 0 273 305 1 2
MCOLN1 PGRMC1 0 0 0 303 1 1
MCOLN1 HSPA4 0 0 444 444 1 1
MCOLN1 ACHE 0 0 292 292 1 2
MCOLN1 RPTOR 0 0 210 210 1 2
MCOLN1 TRPC6 0 0 505 557 1 1
MCOLN1 ABT1 0 0 120 470 1 1
MCOLN1 TLR7 0 0 146 182 1 2
MCOLN1 MTM1 0 0 231 262 1 2
MCOLN1 ITPR1 0 0 377 420 1 2
MCOLN1 FLCN 0 0 242 373 1 1
MCOLN1 ACP2 0 0 202 202 1 1
MCOLN1 BLOC1S2 0 0 112 150 1 1
MCOLN1 SLC39A1 0 0 134 201 1 1
MCOLN1 TIMMDC1 0 0 108 163 1 1
MCOLN1 SLC8B1 0 0 182 236 1 1
MCOLN1 EGF 0 0 167 167 1 2
MCOLN1 CD59 0 0 487 487 1 1
MCOLN1 RAB38 0 0 61 232 1 1
MCOLN1 GLRX3 0 0 60 156 1 1
MCOLN1 ATP6V0D2 0 0 208 429 1 1
MCOLN1 GOLGA3 0 0 75 236 1 1
MCOLN1 TRPM8 0 0 564 653 1 1
MCOLN1 RAB36 0 0 94 202 1 1
MCOLN1 RPS5 0 0 444 444 1 1
MCOLN1 VPS18 0 0 282 372 1 1
MCOLN1 VR1 0 0 684 704 1 1
MCOLN1 STIM2 0 0 180 262 1 1
MCOLN1 GRINA 0 0 0 161 1 1
MCOLN1 CHST2 0 0 77 573 1 1
MCOLN1 FLVCR2 0 0 123 215 1 1
MCOLN1 LYG2 0 0 0 256 1 1
MCOLN1 PIP5K1A 0 0 81 173 1 1
MCOLN1 ADARB2 0 0 53 153 1 1
MCOLN1 LAMP2 0 0 391 429 1 2
MCOLN1 CTSF 0 0 341 456 1 1
MCOLN1 ANK1 0 0 136 223 1 1
MCOLN1 TRPM6 0 0 507 615 1 1
MCOLN1 ENTPD4 0 0 113 172 1 1
MCOLN1 TRPC5 0 0 503 555 1 1
MCOLN1 NCOA4 0 0 184 267 1 2
MCOLN1 MCOLN2 0 800 980 812 1 1
MCOLN1 MCOLN3 412 800 968 882 1 1
MCOLN1 PKD2L2 0 0 609 651 1 1
MCOLN1 TCIRG1 0 0 108 163 1 1
MCOLN1 EHD4 0 0 0 183 1 1
MCOLN1 TRPC7 0 0 54 154 1 1
MCOLN1 MON1B 0 0 0 195 1 1
MCOLN1 ARSA 0 0 150 314 1 2
MCOLN1 GM2A 0 0 229 347 1 1
MCOLN1 SGSH 0 0 235 306 1 1
MCOLN1 NPC2 0 0 381 381 1 1
MCOLN1 SNAP29 0 0 123 167 1 2
MCOLN1 SNCA 0 0 266 266 1 2
MCOLN1 ULK2 0 0 146 176 1 2
MCOLN1 SPTLC3 0 0 74 507 1 1
MCOLN1 HSPA1A 0 0 0 298 1 1
MCOLN1 TPP1 0 0 261 387 1 1
MCOLN1 ERGIC3 0 0 96 357 1 1
MCOLN1 SNX1 0 0 181 247 1 1
MCOLN1 ITPR3 0 0 370 414 1 1
MCOLN1 CNGA1 0 0 181 189 1 1
MCOLN1 HEPH 0 0 158 242 1 1
MCOLN1 KIF5A 0 0 72 164 1 1
MCOLN1 TFEB 0 0 756 801 1 2
MCOLN1 SPG20 0 0 306 306 1 1
MCOLN1 PKD1L3 0 0 314 388 1 1
MCOLN1 SYT1 0 0 141 179 1 1
MCOLN1 PLEKHA1 0 0 125 165 1 1
MCOLN1 RAB29 0 0 81 210 1 1
MCOLN1 SGPL1 0 0 92 559 1 1
MCOLN1 PSEN1 0 0 287 300 1 2
MCOLN1 PAFAH2 0 0 0 230 1 1
MCOLN1 AP3B2 0 0 0 156 1 1
MCOLN1 ACTB 0 0 205 205 1 2
MCOLN1 INS 0 0 167 167 1 2
MCOLN1 ATG13 0 0 260 276 1 2
MCOLN1 DNAJB5 0 0 170 355 1 1
MCOLN1 KCNT1 0 0 161 161 1 1
MCOLN1 ANGPT1 0 0 134 152 1 1
MCOLN1 ULK4 0 0 76 318 1 1
MCOLN1 SYT6 0 0 177 177 1 1
MCOLN1 SQSTM1 0 0 456 467 1 2
MCOLN1 DPP7 0 0 134 243 1 1
MCOLN1 GLI3 0 0 93 657 1 1
MCOLN1 SLC11A2 0 0 394 453 1 1
MCOLN1 ATG9A 0 0 241 329 1 2
MCOLN1 ENSG00000272762 0 0 82 180 1 1
MCOLN1 USP33 0 0 61 177 1 1
MCOLN1 TMEM185A 0 0 125 211 1 1
MCOLN1 GANC 0 0 0 428 1 1
MCOLN1 HSPA8 0 0 895 895 1 2
MCOLN1 STX6 0 0 141 217 1 1
MCOLN1 LRRC8A 0 0 113 174 1 1
MCOLN1 TIMM17A 0 0 0 207 1 1
MCOLN1 TRPM5 0 0 464 546 1 1
MCOLN1 TMEM175 0 0 390 428 1 1
MCOLN1 ATP6V0B 0 0 91 220 1 1
MCOLN1 AKAP9 0 0 59 204 1 1
MCOLN1 GALNT3 0 0 0 302 1 1
MCOLN1 AP3M2 0 0 134 197 1 1
MCOLN1 VPS16 0 0 210 436 1 1
MCOLN1 GABARAPL1 0 0 218 311 1 2
MCOLN1 SEC31A 0 0 204 217 1 1
MCOLN1 SLC46A1 0 0 150 280 1 1
MCOLN1 UNC93B1 0 0 109 282 1 1
MCOLN1 PIP5K1B 0 0 112 248 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0072345 Molecular Function NAADP-sensitive calcium-release channel activity enables IBA
GO:0005262 Molecular Function calcium channel activity enables TAS
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0097682 Molecular Function intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity enables ISS
GO:0005381 Molecular Function iron ion transmembrane transporter activity enables TAS
GO:0099604 Molecular Function ligand-gated calcium channel activity enables IDA
GO:0008289 Molecular Function lipid binding enables IEA
GO:0005261 Molecular Function monoatomic cation channel activity enables NAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0002250 Biological Process adaptive immune response involved_in IEA
GO:0097352 Biological Process autophagosome maturation involved_in IEA
GO:1901660 Biological Process calcium ion export involved_in IDA
GO:0070588 Biological Process calcium ion transmembrane transport involved_in IDA
GO:0070588 Biological Process calcium ion transmembrane transport involved_in TAS
GO:0019722 Biological Process calcium-mediated signaling involved_in IEA
GO:0071277 Biological Process cellular response to calcium ion involved_in ISS
GO:0071467 Biological Process cellular response to pH involved_in ISS
GO:0034755 Biological Process iron ion transmembrane transport involved_in IEA
GO:0051179 Biological Process localization involved_in IDA
GO:0006812 Biological Process monoatomic cation transport involved_in NAS
GO:0090382 Biological Process phagosome maturation involved_in IDA
GO:1905673 Biological Process positive regulation of lysosome organization involved_in IDA
GO:0051289 Biological Process protein homotetramerization involved_in IDA
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IEA
GO:0033572 Biological Process transferrin transport involved_in TAS
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0042995 Cellular Component cell projection located_in IEA
GO:0010008 Cellular Component endosome membrane located_in TAS
GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
GO:0005770 Cellular Component late endosome located_in IDA
GO:0031902 Cellular Component late endosome membrane located_in IEA
GO:0005765 Cellular Component lysosomal membrane located_in HDA
GO:0005765 Cellular Component lysosomal membrane is_active_in IBA
GO:0005765 Cellular Component lysosomal membrane is_active_in IDA
GO:0005764 Cellular Component lysosome located_in IDA
GO:0016020 Cellular Component membrane located_in IDA
GO:0016020 Cellular Component membrane located_in NAS
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0001891 Cellular Component phagocytic cup located_in IEA
GO:0030670 Cellular Component phagocytic vesicle membrane located_in IEA
GO:0005886 Cellular Component plasma membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in NAS
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0043235 Cellular Component receptor complex part_of IDA
Pathways
Name DB ID
Stimuli-sensing channels Reactome R-HSA-2672351
TRP channels Reactome R-HSA-3295583
Transport of small molecules Reactome R-HSA-382551
Iron uptake and transport Reactome R-HSA-917937
Transferrin endocytosis and recycling Reactome R-HSA-917977
Ion channel transport Reactome R-HSA-983712
Iron metabolism in placenta (WP2007) WikiPathways WP2007_r106626
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_020533 3 mRNA None NC_000019 Reference