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BAD

BCL2 associated agonist of cell death
General Information
Name BCL2 associated agonist of cell death
Alias
  • bcl2-associated agonist of cell death
  • BCL-X/BCL-2 binding protein
  • BCL2-antagonist of cell death protein
  • BCL2-binding component 6
  • BCL2-binding protein
  • bcl-2-binding component 6
  • bcl-2-like protein 8
  • bcl-XL/Bcl-2-associated death promoter
  • bcl2 antagonist of cell death
  • bcl2-L-8
Gene_family BCL2 homology region 3 (BH3) only
organism Homo sapiens
entrez_id 572
location 11q13.1
transcript_count 2
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]
    Stringdb Bcl2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
    nextProt Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
BAD BioGRID PMAIP1 GeneID BioGRID Negative Genetic
BAD BioGRID BOK GeneID BioGRID Negative Genetic
BAD BioGRID BNIP3L GeneID BioGRID Negative Genetic
BAD BioGRID BIK GeneID BioGRID Negative Genetic
BAD BioGRID BID GeneID BioGRID Negative Genetic
BAD BioGRID BAX GeneID BioGRID Affinity Capture-Western; Negative Genetic
BAD BioGRID BAK1 GeneID BioGRID Negative Genetic
BAD BioGRID BMF GeneID BioGRID Negative Genetic
BAD BioGRID BCL2L12 GeneID BioGRID Negative Genetic
BAD BioGRID BCL2L14 GeneID BioGRID Negative Genetic
BAD BioGRID BBC3 GeneID BioGRID Negative Genetic
BAD BioGRID BCL2L13 GeneID BioGRID Negative Genetic
BAD BioGRID BCL2L11 GeneID BioGRID Negative Genetic
BAD BioGRID HRK GeneID BioGRID Negative Genetic
BAD BioGRID SFN GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BAD BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BAD BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
BAD BioGRID YWHAH GeneID BioGRID Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BAD BioGRID YWHAG GeneID BioGRID Affinity Capture-MS; Two-hybrid
BAD BioGRID YWHAE GeneID BioGRID Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BAD BioGRID YWHAB GeneID BioGRID Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BAD BioGRID SPPL3 GeneID BioGRID Positive Genetic
BAD BioGRID CHEK1 GeneID BioGRID Biochemical Activity
BAD BioGRID RAF1 GeneID BioGRID Biochemical Activity; Co-localization
BAD BioGRID MAPK8 GeneID BioGRID Co-localization
BAD BioGRID NARS1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID BCL2L1 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western; Co-localization; FRET; Protein-peptide; Reconstituted Complex; Two-hybrid
BAD BioGRID BCL2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Far Western; Protein-peptide; Reconstituted Complex; Two-hybrid
BAD BioGRID APTX GeneID BioGRID Affinity Capture-MS
BAD BioGRID GAN GeneID BioGRID Affinity Capture-MS
BAD BioGRID AGK GeneID BioGRID Affinity Capture-MS
BAD BioGRID IPO9 GeneID BioGRID Affinity Capture-MS
BAD BioGRID ATAD3A GeneID BioGRID Affinity Capture-MS
BAD BioGRID GEMIN4 GeneID BioGRID Affinity Capture-MS
BAD BioGRID HOOK2 GeneID BioGRID Affinity Capture-MS
BAD BioGRID AKAP8L GeneID BioGRID Affinity Capture-MS
BAD BioGRID TIMM9 GeneID BioGRID Affinity Capture-MS
BAD BioGRID DDX20 GeneID BioGRID Affinity Capture-MS
BAD BioGRID ERLIN1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID IPO7 GeneID BioGRID Affinity Capture-MS
BAD BioGRID ATP5MF GeneID BioGRID Affinity Capture-MS
BAD BioGRID MTA2 GeneID BioGRID Affinity Capture-MS
BAD BioGRID SGPL1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID SLC25A11 GeneID BioGRID Affinity Capture-MS
BAD BioGRID SNCA GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
BAD BioGRID SMN1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID RBBP4 GeneID BioGRID Affinity Capture-MS
BAD BioGRID ABCD3 GeneID BioGRID Affinity Capture-MS
BAD BioGRID PRKDC GeneID BioGRID Affinity Capture-MS
BAD BioGRID PRKCA GeneID BioGRID Affinity Capture-MS
BAD BioGRID PRKAR1A GeneID BioGRID Affinity Capture-MS
BAD BioGRID PRKACB GeneID BioGRID Affinity Capture-MS
BAD BioGRID PRKAA1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID PPP6C GeneID BioGRID Affinity Capture-MS
BAD BioGRID PPP2R5E GeneID BioGRID Affinity Capture-MS
BAD BioGRID PPP2R5C GeneID BioGRID Affinity Capture-MS
BAD BioGRID PPP2R1B GeneID BioGRID Affinity Capture-MS
BAD BioGRID PPP2R1A GeneID BioGRID Affinity Capture-MS
BAD BioGRID PPP2CA GeneID BioGRID Affinity Capture-MS
BAD BioGRID SLC25A3 GeneID BioGRID Affinity Capture-MS
BAD BioGRID KPNB1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID HSPD1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID HSPB1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
BAD BioGRID HSPA6 GeneID BioGRID Affinity Capture-MS
BAD BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
BAD BioGRID HDAC2 GeneID BioGRID Affinity Capture-MS
BAD BioGRID GLG1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID EMD GeneID BioGRID Affinity Capture-MS
BAD BioGRID CYC1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID SLC25A10 GeneID BioGRID Affinity Capture-MS
BAD BioGRID CAD GeneID BioGRID Affinity Capture-MS
BAD BioGRID CAVIN1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID OSBPL8 GeneID BioGRID Affinity Capture-MS
BAD BioGRID MCU GeneID BioGRID Affinity Capture-MS
BAD BioGRID ATAD3B GeneID BioGRID Affinity Capture-MS
BAD BioGRID OBI1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID KNL1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID BAD GeneID BioGRID Affinity Capture-MS
BAD BioGRID KRT31 GeneID BioGRID Two-hybrid
BAD BioGRID BCL2L2 GeneID BioGRID Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
BAD BioGRID ACTN2 GeneID BioGRID Two-hybrid
BAD BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
BAD BioGRID ULK1 GeneID BioGRID Affinity Capture-Western
BAD BioGRID PAK1 GeneID BioGRID Biochemical Activity
BAD BioGRID AKT1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex
BAD BioGRID PIM1 GeneID BioGRID Biochemical Activity
BAD BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
BAD BioGRID CBY1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID Brca1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID NDUFA12 GeneID BioGRID Affinity Capture-MS
BAD BioGRID SYNCRIP GeneID BioGRID Affinity Capture-MS
BAD BioGRID SORT1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID LIMK1 GeneID BioGRID Affinity Capture-MS
BAD BioGRID PRKD1 GeneID BioGRID Affinity Capture-Western
BAD BioGRID PRKCE GeneID BioGRID Affinity Capture-Western
BAD BioGRID GIMAP5 GeneID BioGRID Affinity Capture-Western
BAD BioGRID BMH1 GeneID BioGRID Reconstituted Complex
BAD BioGRID PRKACA GeneID BioGRID Biochemical Activity; Reconstituted Complex
BAD BioGRID BRAF GeneID BioGRID Biochemical Activity
BAD BioGRID ARAF GeneID BioGRID Biochemical Activity
BAD BioGRID CREB3L3 GeneID BioGRID Two-hybrid
BAD BioGRID STEAP3 GeneID BioGRID Two-hybrid
BAD BioGRID KEAP1 GeneID BioGRID Two-hybrid
BAD BioGRID PRDX2 GeneID BioGRID Two-hybrid
BAD BioGRID CDKN1A GeneID BioGRID Two-hybrid
BAD BioGRID VCP GeneID BioGRID Affinity Capture-Western
BAD BioGRID PPP1CA GeneID BioGRID Affinity Capture-Western
BAD BioGRID SUMO2 GeneID BioGRID Two-hybrid
BAD Protein PPP1CA GeneID HPRD
BAD Protein PIM3 GeneID HPRD
BAD Protein MCL1 GeneID HPRD
BAD Protein RPS6KA5 GeneID HPRD
BAD Protein PAK5 GeneID HPRD
BAD Protein BCL2L10 GeneID HPRD
BAD Protein YWHAG GeneID HPRD
BAD Protein YWHAE GeneID HPRD
BAD Protein WASF1 GeneID HPRD
BAD Protein HRK GeneID HPRD
BAD Protein PAK1 GeneID HPRD
BAD Protein MAP2K5 GeneID HPRD
BAD Protein BCL2L2 GeneID HPRD
BAD Protein RPS6KA2 GeneID HPRD
BAD Protein RPS6KA1 GeneID HPRD
BAD Protein PRKACA GeneID HPRD
BAD Protein SFN GeneID HPRD
BAD Protein YWHAB GeneID HPRD
BAD Protein YWHAZ GeneID HPRD
BAD Protein MAPK8 GeneID HPRD
BAD Protein BCL2A1 GeneID HPRD
BAD Protein BCL2L1 GeneID HPRD
BAD Protein PIM2 GeneID HPRD
BAD Protein RPS6KA3 GeneID HPRD
BAD Protein PIM1 GeneID HPRD
BAD Protein RAF1 GeneID HPRD
BAD Protein AKT1 GeneID HPRD
BAD Protein SNCA GeneID HPRD
BAD Protein BCL2 GeneID HPRD
BAD Protein YWHAQ GeneID HPRD
BAD Protein EWSR1 GeneID HPRD
BAD Protein PPP3CA GeneID HPRD
BAD Protein S100A10 GeneID HPRD
BAD Protein YWHAH GeneID HPRD
BAD BioGRID BCL2A1 GeneID BioGRID Protein-peptide; Reconstituted Complex; Two-hybrid
BAD BioGRID MCL1 GeneID BioGRID Protein-peptide; Reconstituted Complex; Two-hybrid
BAD BioGRID PIM2 GeneID BioGRID Biochemical Activity
BAD BioGRID RPS6KA5 GeneID BioGRID Reconstituted Complex
BAD BioGRID S100A10 GeneID BioGRID Reconstituted Complex; Two-hybrid
BAD BioGRID RPS6KA1 GeneID BioGRID Reconstituted Complex
BAD BioGRID PRKCI GeneID BioGRID Reconstituted Complex
BAD BioGRID EWSR1 GeneID BioGRID Two-hybrid
BAD Protein BCL2L1 GeneID BIND Bad interacts with Bcl-XL.
BAD Protein BCL2 GeneID BIND Bad interacts with Bcl-2.
BAD Protein BCL2A1 GeneID BIND Bad interacts with A1. This interaction was modelled on a demonstrated interaction between human Bad and mouse A1.
BAD Protein BCL2L2 GeneID BIND Bad interacts with Bcl-w.
BAD Protein BCL2L1 GeneID BIND Bad interacts with Bcl-xL.
BAD Protein BCL2 GeneID BIND Bad interacts with Bcl-2.
BAD None None None BIND Bcl-XL interacts with Bad. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bad.
BAD Protein BCL2 GeneID BIND Bcl-2 interacts with Bad.
StringDB
A B experiments database textmining combined score hadb nhadb
BAD PRKD1 270 0 54 279 1 1
BAD BCL2L14 0 0 75 260 1 1
BAD RPTOR 0 0 166 165 1 2
BAD KSR1 0 0 66 150 1 1
BAD MCL1 867 0 470 941 1 2
BAD BFAR 0 0 90 185 1 1
BAD PAWR 0 0 123 161 1 1
BAD EGF 0 0 181 181 1 2
BAD PIM2 270 0 279 451 1 1
BAD ESR1 0 0 180 179 1 2
BAD MAPK9 0 900 67 903 1 2
BAD PPP1CA 275 0 0 332 1 1
BAD RAC1 0 650 81 670 1 2
BAD LYN 0 0 74 196 1 1
BAD CYCS 0 900 503 948 1 2
BAD CAMKK1 0 0 0 150 1 1
BAD RPS6KA3 213 0 249 383 1 1
BAD CHEK2 0 0 123 195 1 1
BAD MAP3K5 0 0 324 323 1 1
BAD HK1 0 0 58 179 1 1
BAD CASP9 0 0 517 520 1 2
BAD ACTN2 242 0 0 241 1 1
BAD ULK1 270 0 166 438 1 2
BAD PPP3R2 0 800 0 802 1 1
BAD PRKAR1B 0 900 74 906 1 1
BAD PRKCA 130 0 90 174 1 1
BAD BRAF 270 0 108 406 1 2
BAD RPS6KA1 462 0 359 640 1 1
BAD EVC 0 0 95 234 1 1
BAD AKT3 0 900 216 928 1 2
BAD MAPK8 682 900 244 973 1 2
BAD DAPK3 0 0 108 503 1 2
BAD POLR2L 0 0 81 187 1 1
BAD CISH 0 0 63 156 1 1
BAD HSPB1 128 0 122 221 1 2
BAD POLR2E 0 0 67 203 1 1
BAD DIABLO 0 0 359 373 1 2
BAD UBAP2L 0 0 95 615 1 1
BAD DFFB 0 0 166 462 1 1
BAD GPX4 0 0 92 193 1 2
BAD CLTB 0 0 81 219 1 1
BAD TRADD 0 0 242 277 1 1
BAD CALML6 0 0 139 231 1 1
BAD FLT3 0 0 160 159 1 2
BAD MAGED1 0 650 0 650 1 1
BAD INCA1 0 0 143 232 1 1
BAD PPP3R1 0 900 0 901 1 1
BAD CDH1 0 0 150 178 1 2
BAD BCL2L10 213 0 213 483 1 1
BAD TCTN1 0 0 74 159 1 1
BAD SHC1 0 0 227 226 1 1
BAD PADI3 0 0 310 318 1 1
BAD ATM 0 0 124 156 1 2
BAD CDK16 0 0 0 216 1 1
BAD CA4 0 0 0 256 1 1
BAD CDK6 0 0 123 154 1 2
BAD YWHAG 468 900 76 949 1 1
BAD SYK 0 0 112 230 1 2
BAD NFKBIA 0 0 157 156 1 2
BAD TNFRSF10A 0 0 175 180 1 1
BAD PRKG2 0 800 0 800 1 1
BAD PTRF 117 0 0 170 1 1
BAD BIRC3 0 0 213 214 1 1
BAD COX8A 0 0 60 154 1 1
BAD NGFR 0 650 74 666 1 1
BAD MARK2 0 0 154 179 1 1
BAD TP53BP2 0 0 766 766 1 2
BAD MAPK10 0 900 75 905 1 2
BAD LRRFIP2 0 0 57 187 1 1
BAD MAPK14 0 0 143 244 1 2
BAD CDK5 0 0 58 161 1 2
BAD CASP7 0 0 260 297 1 1
BAD PTEN 0 0 325 326 1 2
BAD RPL10A 0 0 54 151 1 1
BAD TXN2 0 0 95 227 1 1
BAD VEGFA 0 0 235 235 1 2
BAD ALB 0 0 155 162 1 2
BAD CASP8 0 0 458 479 1 2
BAD UBAP2 0 0 0 261 1 1
BAD CASP5 0 0 134 216 1 1
BAD CASP3 0 900 502 948 1 2
BAD HTRA2 0 0 234 250 1 1
BAD PSEN1 0 0 75 174 1 2
BAD PDCD10 0 0 53 440 1 1
BAD LIMK1 168 0 48 199 1 1
BAD EIF4B 0 0 170 194 1 1
BAD HADH 0 0 235 443 1 1
BAD CHRNB3 0 0 0 190 1 1
BAD HNRNPL 270 0 0 270 1 1
BAD MMP9 0 0 150 171 1 2
BAD MAPK3 0 900 294 928 1 2
BAD ROS1 0 0 46 219 1 1
BAD BNIP3 0 0 209 209 1 2
BAD LRRC37B 0 0 167 167 1 1
BAD VPS13A 0 0 73 170 1 1
BAD INS 0 0 260 260 1 2
BAD TNFRSF10B 0 0 242 246 1 2
BAD ACTB 0 0 243 242 1 2
BAD BAX 419 0 681 845 1 2
BAD GSK3B 0 0 280 355 1 2
BAD CDKN1A 111 0 289 340 1 2
BAD MTCH2 0 0 56 176 1 1
BAD SFN 830 900 61 983 1 2
BAD BID 0 650 654 876 1 2
BAD CASP4 0 0 194 270 1 2
BAD PARP1 0 0 106 167 1 2
BAD RHOA 0 0 139 165 1 2
BAD CDKN2A 0 0 193 193 1 2
BAD RIPK1 0 0 142 213 1 2
BAD YWHAH 674 900 113 969 1 1
BAD WNK2 0 0 0 188 1 1
BAD BCL10 0 0 134 224 1 1
BAD STAT5A 0 0 181 181 1 1
BAD LTA 0 0 107 150 1 1
BAD TBC1D4 0 0 150 214 1 1
BAD PRKAR1A 131 900 54 910 1 2
BAD YWHAE 692 900 134 972 1 1
BAD FYN 0 0 95 258 1 1
BAD FASLG 0 0 292 297 1 1
BAD GRB2 131 0 240 325 1 1
BAD FOS 0 0 162 161 1 2
BAD CHI3L2 0 0 72 442 1 1
BAD YWHAZ 897 900 112 990 1 1
BAD SOD2 0 0 0 173 1 2
BAD PRKACB 130 900 0 919 1 1
BAD MMP2 0 0 150 173 1 2
BAD RIPK2 0 0 61 155 1 2
BAD SYNCRIP 128 0 0 163 1 1
BAD FOXO1 0 0 324 323 1 2
BAD KRAS 0 0 123 187 1 2
BAD BIK 0 0 460 471 1 2
BAD SAE1 0 0 61 229 1 1
BAD IRS2 0 0 190 190 1 1
BAD PIK3CG 0 0 138 169 1 1
BAD MET 0 0 108 159 1 2
BAD BOK 0 0 467 584 1 1
BAD TRAF3 0 0 103 164 1 2
BAD MAPK11 0 0 0 178 1 1
BAD PIM3 213 0 144 297 1 1
BAD PMAIP1 0 0 466 465 1 2
BAD TNFSF10 0 0 261 261 1 2
BAD FZD10 0 0 49 262 1 1
BAD CASP1 0 0 166 216 1 2
BAD OGFOD3 0 0 306 426 1 1
BAD AKT1S1 0 0 321 349 1 1
BAD BECN1 270 0 195 387 1 2
BAD SNCA 643 900 75 965 1 2
BAD BRAT1 0 0 113 168 1 1
BAD DNTT 0 0 194 194 1 1
BAD LPIN1 0 0 0 293 1 2
BAD DAPK1 0 0 181 284 1 2
BAD DAD1 0 0 108 454 1 1
BAD JUN 0 0 335 335 1 2
BAD PAK4 0 0 151 150 1 1
BAD BCL2L11 270 900 559 964 1 2
BAD ABL1 0 0 164 212 1 1
BAD MAP2K7 0 0 233 232 1 1
BAD RPS6KA5 462 0 150 523 1 1
BAD RD3 0 0 0 206 1 1
BAD FKBP8 0 0 0 191 1 1
BAD GAPDH 0 0 218 218 1 2
BAD SLC25A11 131 0 0 151 1 1
BAD XIAP 0 0 322 334 1 2
BAD AKT1 870 900 559 994 1 2
BAD CAPN1 177 0 0 194 1 2
BAD BCL2L1 913 900 926 999 1 2
BAD RPL13 0 0 165 208 1 1
BAD NFKB1 0 0 112 185 1 2
BAD PARP4 0 0 84 383 1 1
BAD CASP6 0 0 212 216 1 1
BAD FAS 0 0 263 312 1 2
BAD NDUFA12 710 0 0 710 1 1
BAD ATF4 0 0 92 191 1 2
BAD AIFM1 0 900 70 914 1 1
BAD NGF 0 650 139 685 1 2
BAD ERBB2 0 0 218 218 1 2
BAD DHODH 0 0 49 437 1 1
BAD ANXA5 0 0 279 294 1 2
BAD YES1 0 0 69 154 1 1
BAD CCNB1 0 0 150 190 1 1
BAD DENR 0 0 48 232 1 1
BAD BBC3 0 0 518 518 1 2
BAD CREB1 0 0 212 212 1 2
BAD BIRC2 0 0 161 162 1 1
BAD GSK3A 0 0 202 246 1 1
BAD PPP3CA 213 800 0 835 1 1
BAD EIF4EBP1 0 0 320 337 1 2
BAD RTN4 0 0 0 190 1 1
BAD PRKACA 698 900 103 977 1 1
BAD RPS6 0 0 162 161 1 2
BAD TNFRSF1A 0 0 220 227 1 1
BAD PLEK 0 0 203 203 1 1
BAD XK 0 0 171 171 1 1
BAD ENDOG 0 0 261 333 1 1
BAD TXNDC9 0 0 171 171 1 1
BAD BCL2L2-PABPN1 0 0 375 500 1 1
BAD BTBD10 0 0 142 167 1 1
BAD IL6 0 0 193 193 1 2
BAD PIK3C3 0 0 194 194 1 2
BAD PRKG1 0 800 0 800 1 1
BAD SORT1 168 0 0 167 1 1
BAD MTOR 0 0 414 414 1 2
BAD YWHAB 693 900 166 974 1 1
BAD SLC2A4 0 0 155 154 1 1
BAD FOXO3 0 0 288 288 1 2
BAD SRC 0 0 242 311 1 2
BAD ARAF 270 0 107 368 1 1
BAD PRMT1 0 0 254 254 1 1
BAD CDC42 0 0 161 161 1 2
BAD PSEN2 0 0 218 231 1 1
BAD BNIP3L 270 0 108 371 1 2
BAD PRKAR2B 0 900 0 900 1 1
BAD STAT5B 0 0 181 181 1 1
BAD TSC2 0 0 323 323 1 2
BAD VDAC1 0 0 113 191 1 2
BAD PASK 0 0 60 185 1 1
BAD APP 57 0 94 207 1 2
BAD CLEC18A 0 0 156 155 1 1
BAD FCRL3 0 0 60 249 1 1
BAD PDCD7 0 0 137 428 1 1
BAD CTNNB1 0 0 203 203 1 2
BAD HRAS 0 0 148 214 1 2
BAD CDK2 0 0 143 153 1 2
BAD PRKCD 0 900 113 907 1 2
BAD GIMAP5 270 0 0 270 1 1
BAD CDKN1B 0 0 218 218 1 2
BAD TCHP 0 0 193 193 1 1
BAD WNK3 0 0 0 159 1 1
BAD IL1B 0 0 166 165 1 2
BAD WASF1 213 0 329 511 1 1
BAD HIF1A 0 0 175 175 1 2
BAD KDR 0 0 122 176 1 2
BAD GCK 0 0 582 643 1 1
BAD HRK 213 0 414 519 1 1
BAD S100A10 270 0 610 722 1 1
BAD STAT3 0 0 218 218 1 2
BAD WNK1 100 0 0 332 1 1
BAD TMEM160 0 0 0 168 1 1
BAD UACA 0 0 95 234 1 1
BAD CDIP1 0 0 0 189 1 1
BAD PRKAR2A 0 900 0 900 1 1
BAD ERN1 0 0 155 181 1 2
BAD PDPK1 0 650 181 701 1 2
BAD CISD2 270 0 0 270 1 2
BAD DFFA 0 0 122 216 1 1
BAD PIN1 0 0 60 161 1 1
BAD RHEB 0 0 206 235 1 2
BAD APAF1 0 0 391 390 1 2
BAD DDX46 0 0 75 156 1 1
BAD PDCD6 0 0 74 327 1 1
BAD BAK1 0 0 517 613 1 2
BAD AVEN 0 0 74 480 1 1
BAD BCL2 882 900 505 995 1 2
BAD PAK1 731 0 132 756 1 2
BAD PRKACG 0 900 0 916 1 1
BAD TNFRSF11B 0 0 49 150 1 1
BAD CRADD 0 0 210 246 1 1
BAD HDAC2 257 0 54 267 1 1
BAD BCL2L2 870 0 459 941 1 1
BAD STIM1 0 0 0 211 1 2
BAD DVL2 0 0 0 189 1 2
BAD PRKAA1 117 0 96 167 1 2
BAD HK2 0 0 119 263 1 2
BAD CCND1 0 0 294 294 1 2
BAD PDCD2 0 0 150 292 1 1
BAD RAF1 872 900 185 990 1 2
BAD CFLAR 0 0 322 321 1 2
BAD EGFR 0 0 247 246 1 2
BAD CDK4 0 0 135 181 1 2
BAD RPS6KB1 0 0 325 325 1 2
BAD PPP1CC 0 0 427 438 1 1
BAD YWHAQ 870 900 108 987 1 1
BAD EIF4E 0 0 155 185 1 2
BAD CDK1 0 0 182 192 1 2
BAD FADD 0 0 370 391 1 2
BAD NTRK1 0 0 123 172 1 1
BAD BNIP2 0 0 135 189 1 1
BAD PRKCE 270 0 96 311 1 1
BAD MDM2 0 0 323 325 1 2
BAD TP53 0 0 640 640 1 2
BAD PRKCI 270 0 0 292 1 1
BAD MAP2K1 0 800 181 829 1 1
BAD CARD10 0 0 54 428 1 1
BAD USP38 0 0 82 178 1 1
BAD MAPK1 0 900 164 915 1 2
BAD AKT2 0 900 181 925 1 2
BAD IGF1 0 0 218 218 1 2
BAD PAK7 213 0 125 283 1 1
BAD SOCS1 0 0 107 162 1 1
BAD MAP2K5 213 0 69 235 1 1
BAD RPS6KA2 213 0 308 432 1 1
BAD SOS1 0 0 150 169 1 1
BAD CASP10 0 0 251 280 1 1
BAD CMIP 0 0 74 199 1 1
BAD ST20 0 0 0 232 1 1
BAD CIDEB 0 0 75 217 1 1
BAD BCL2A1 867 0 294 921 1 1
BAD PPP3CC 0 900 74 903 1 1
BAD NOL3 0 0 122 210 1 1
BAD BMF 0 0 493 493 1 1
BAD PIK3CA 0 0 171 253 1 2
BAD PPP3CB 0 800 0 800 1 1
BAD DVL1 0 0 53 228 1 1
BAD PIK3R3 0 0 155 154 1 1
BAD PIM1 463 0 292 603 1 1
BAD RICTOR 0 0 150 173 1 2
BAD TRAF2 0 0 109 164 1 2
BAD TMBIM6 0 0 101 162 1 1
BAD TNF 0 0 218 218 1 2
BAD IGF1R 0 0 218 242 1 2
BAD C22orf29 0 0 436 436 1 1
BAD BDNF 0 0 137 162 1 2
BAD CASP2 0 0 270 321 1 1
BAD PDK1 0 0 108 202 1 2
BAD MYC 0 0 299 299 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0008656 Molecular Function cysteine-type endopeptidase activator activity involved in apoptotic process enables IBA
GO:0008656 Molecular Function cysteine-type endopeptidase activator activity involved in apoptotic process enables IDA
GO:0008289 Molecular Function lipid binding enables IDA
GO:0005543 Molecular Function phospholipid binding enables IMP
GO:0005515 Molecular Function protein binding enables IPI
GO:0019901 Molecular Function protein kinase binding enables IBA
GO:0019901 Molecular Function protein kinase binding enables IPI
GO:0019903 Molecular Function protein phosphatase binding enables IBA
GO:0046031 Biological Process ADP metabolic process involved_in ISS
GO:0046034 Biological Process ATP metabolic process involved_in ISS
GO:0097202 Biological Process activation of cysteine-type endopeptidase activity involved_in IBA
GO:0097202 Biological Process activation of cysteine-type endopeptidase activity involved_in IDA
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in ISS
GO:0006915 Biological Process apoptotic process involved_in IDA
GO:0006915 Biological Process apoptotic process involved_in TAS
GO:0071456 Biological Process cellular response to hypoxia involved_in IBA
GO:0071456 Biological Process cellular response to hypoxia involved_in IEP
GO:0071396 Biological Process cellular response to lipid involved_in IEA
GO:0071260 Biological Process cellular response to mechanical stimulus involved_in IEP
GO:0071316 Biological Process cellular response to nicotine involved_in IDA
GO:0019221 Biological Process cytokine-mediated signaling pathway involved_in IEA
GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IBA
GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IMP
GO:0097192 Biological Process extrinsic apoptotic signaling pathway in absence of ligand involved_in IEA
GO:0008625 Biological Process extrinsic apoptotic signaling pathway via death domain receptors involved_in IEA
GO:0006007 Biological Process glucose catabolic process involved_in IEA
GO:0042593 Biological Process glucose homeostasis involved_in ISS
GO:0097193 Biological Process intrinsic apoptotic signaling pathway involved_in IBA
GO:0097193 Biological Process intrinsic apoptotic signaling pathway involved_in IMP
GO:0008630 Biological Process intrinsic apoptotic signaling pathway in response to DNA damage involved_in IEA
GO:0046931 Biological Process pore complex assembly involved_in IDA
GO:0045579 Biological Process positive regulation of B cell differentiation involved_in IEA
GO:0045582 Biological Process positive regulation of T cell differentiation involved_in IEA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IMP
GO:0043065 Biological Process positive regulation of apoptotic process involved_in NAS
GO:0010508 Biological Process positive regulation of autophagy involved_in TAS
GO:0043280 Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IDA
GO:0050679 Biological Process positive regulation of epithelial cell proliferation involved_in IMP
GO:0033133 Biological Process positive regulation of glucokinase activity involved_in ISS
GO:0032024 Biological Process positive regulation of insulin secretion involved_in ISS
GO:0035774 Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulus involved_in IEA
GO:1902220 Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress involved_in IEA
GO:0010918 Biological Process positive regulation of mitochondrial membrane potential involved_in ISS
GO:0045862 Biological Process positive regulation of proteolysis involved_in IDA
GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in IMP
GO:2000078 Biological Process positive regulation of type B pancreatic cell development involved_in ISS
GO:0046902 Biological Process regulation of mitochondrial membrane permeability involved_in IBA
GO:0046902 Biological Process regulation of mitochondrial membrane permeability involved_in IMP
GO:0001836 Biological Process release of cytochrome c from mitochondria involved_in IBA
GO:0044342 Biological Process type B pancreatic cell proliferation involved_in ISS
GO:0097138 Cellular Component BAD-BCL-2 complex part_of IPI
GO:0005829 Cellular Component cytosol is_active_in IBA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005741 Cellular Component mitochondrial outer membrane located_in IDA
GO:0005741 Cellular Component mitochondrial outer membrane located_in TAS
GO:0005739 Cellular Component mitochondrion is_active_in IBA
GO:0005739 Cellular Component mitochondrion located_in IDA
Pathways
Name DB ID
Apoptosis Reactome R-HSA-109581
Intrinsic Pathway for Apoptosis Reactome R-HSA-109606
Activation of BAD and translocation to mitochondria Reactome R-HSA-111447
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Reactome R-HSA-111453
Activation of BH3-only proteins Reactome R-HSA-114452
PIP3 activates AKT signaling Reactome R-HSA-1257604
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
NRAGE signals death through JNK Reactome R-HSA-193648
p75 NTR receptor-mediated signalling Reactome R-HSA-193704
AKT phosphorylates targets in the cytosol Reactome R-HSA-198323
Cell death signalling via NRAGE, NRIF and NADE Reactome R-HSA-204998
PI3K/AKT Signaling in Cancer Reactome R-HSA-2219528
Programmed Cell Death Reactome R-HSA-5357801
Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
Constitutive Signaling by AKT1 E17K in Cancer Reactome R-HSA-5674400
Death Receptor Signaling Reactome R-HSA-73887
Intracellular signaling by second messengers Reactome R-HSA-9006925
MET in type 1 papillary renal cell carcinoma (WP4205) WikiPathways WP4205_r118937
Focal adhesion (WP306) WikiPathways WP306_r116784
Integrated cancer pathway (WP1971) WikiPathways WP1971_r117762
Chromosomal and microsatellite instability in colorectal cancer (WP4216) WikiPathways WP4216_r123363
Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
Measles virus infection (WP4630) WikiPathways WP4630_r123414
Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
EGFR tyrosine kinase inhibitor resistance (WP4806) WikiPathways WP4806_r123492
IL6 signaling pathway (WP364) WikiPathways WP364_r121718
Ras signaling (WP4223) WikiPathways WP4223_r119284
Melanoma (WP4685) WikiPathways WP4685_r123437
ErbB signaling pathway (WP673) WikiPathways WP673_r118930
Thyroid hormones production and peripheral downstream signaling effects (WP4746) WikiPathways WP4746_r123317
IL-3 signaling pathway (WP286) WikiPathways WP286_r120663
Amyotrophic lateral sclerosis (ALS) (WP2447) WikiPathways WP2447_r113794
miRNA regulation of prostate cancer signaling pathways (WP3981) WikiPathways WP3981_r108114
Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
IL-4 signaling pathway (WP395) WikiPathways WP395_r120704
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844) WikiPathways WP3844_r107714
NO/cGMP/PKG mediated neuroprotection (WP4008) WikiPathways WP4008_r123318
IL-18 signaling pathway (WP4754) WikiPathways WP4754_r115147
Focal adhesion: PI3K-Akt-mTOR-signaling pathway (WP3932) WikiPathways WP3932_r124527
Oxidative damage response (WP3941) WikiPathways WP3941_r123242
Brain-derived neurotrophic factor (BDNF) signaling pathway (WP2380) WikiPathways WP2380_r120727
DNA damage response (only ATM dependent) (WP710) WikiPathways WP710_r116542
Leptin signaling pathway (WP2034) WikiPathways WP2034_r120670
RAC1/PAK1/p38/MMP2 pathway (WP3303) WikiPathways WP3303_r123243
Host-pathogen interaction of human coronaviruses - apoptosis (WP4864) WikiPathways WP4864_r124634
Gastrin signaling pathway (WP4659) WikiPathways WP4659_r116555
Apoptosis (WP254) WikiPathways WP254_r118382
Pancreatic adenocarcinoma pathway (WP4263) WikiPathways WP4263_r123405
IL-7 signaling pathway (WP205) WikiPathways WP205_r120718
TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
Non-small cell lung cancer (WP4255) WikiPathways WP4255_r123348
Kit receptor signaling pathway (WP304) WikiPathways WP304_r120696
Endometrial cancer (WP4155) WikiPathways WP4155_r123347
PI3K-Akt signaling pathway (WP4172) WikiPathways WP4172_r122580
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_004322 3 mRNA transcript variant 1 NC_000011 Reference
NM_032989 3 mRNA transcript variant 2 NC_000011 Reference