PTK2

protein tyrosine kinase 2

General Information

Name	protein tyrosine kinase 2
Alias	focal adhesion kinase 1 FAK-related non-kinase polypeptide PTK2 protein tyrosine kinase 2 focal adhesion kinase-related nonkinase protein phosphatase 1 regulatory subunit 71
Gene_family	Protein phosphatase 1 regulatory subunits\|MicroRNA protein coding host genes\|FERM domain containing\|PTK2 family tyrosine kinases
organism	Homo sapiens
entrez_id	5747
location	8q24.3
transcript_count	181
exon_count	48

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Stringdb Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...]

nextProt (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Interactions

NCBI

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PTK2	BioGRID	PTK2B	GeneID	BioGRID	Negative Genetic
PTK2	BioGRID	PLK1	GeneID	BioGRID	Affinity Capture-Western
PTK2	BioGRID	OTULIN	GeneID	BioGRID	Affinity Capture-MS
PTK2	BioGRID	RAB25	GeneID	BioGRID	Proximity Label-MS
PTK2	BioGRID	GOLGA2	GeneID	BioGRID	Affinity Capture-MS
PTK2	BioGRID	F13A1	GeneID	BioGRID	Affinity Capture-MS; Two-hybrid
PTK2	BioGRID	DDX43	GeneID	BioGRID	Affinity Capture-MS
PTK2	BioGRID	STAU1	GeneID	BioGRID	Proximity Label-MS
PTK2	BioGRID	TRIM67	GeneID	BioGRID	Affinity Capture-MS
PTK2	BioGRID	WEE2-AS1	GeneID	BioGRID	Protein-RNA

Showing 1 to 10 of 373 entries

StringDB

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PTK2	FGB	0	600	0	600	1	1
PTK2	SH3GL1	0	900	138	911	1	1
PTK2	SKAP1	0	0	137	170	1	1
PTK2	CCNA1	444	0	116	487	1	1
PTK2	COMMD3-BMI1	0	0	207	207	1	1
PTK2	KIT	0	0	380	255	1	2
PTK2	FERMT3	0	0	233	267	1	1
PTK2	RTCB	0	0	391	390	1	1
PTK2	LDHA	0	0	163	163	1	2
PTK2	AMBRA1	0	0	225	264	1	2

Showing 1 to 10 of 1,523 entries

Ontologies

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GO:0001525	Biological Process	angiogenesis	involved_in	IBA
GO:0001525	Biological Process	angiogenesis	involved_in	TAS
GO:0001725	Cellular Component	stress fiber	located_in	IDA
GO:0001890	Biological Process	placenta development	involved_in	TAS
GO:0001932	Biological Process	regulation of protein phosphorylation	involved_in	IGI
GO:0001934	Biological Process	positive regulation of protein phosphorylation	involved_in	IMP
GO:0003007	Biological Process	heart morphogenesis	involved_in	TAS
GO:0003779	Molecular Function	actin binding	enables	IDA
GO:0004713	Molecular Function	protein tyrosine kinase activity	enables	EXP
GO:0004713	Molecular Function	protein tyrosine kinase activity	enables	TAS

Showing 1 to 10 of 83 entries

Pathways

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2q13 copy number variation syndrome (WP5222)	WikiPathways	WP5222_r122737
Alpha 6 beta 4 signaling pathway (WP244)	WikiPathways	WP244_r120686
Androgen receptor signaling pathway (WP138)	WikiPathways	WP138_r122133
Angiogenesis (WP1539)	WikiPathways	WP1539_r118358
Apoptosis	Reactome	R-HSA-109581
Apoptosis-related network due to altered Notch3 in ovarian cancer (WP2864)	WikiPathways	WP2864_r108133
Apoptotic cleavage of cellular proteins	Reactome	R-HSA-111465
Apoptotic execution phase	Reactome	R-HSA-75153
Axon guidance	Reactome	R-HSA-422475
Cell-Cell communication	Reactome	R-HSA-1500931

Showing 1 to 10 of 84 entries

Transcripts

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NM_001199649	2	mRNA	transcript variant 3	NC_000008	Reference
NM_001316342	2	mRNA	transcript variant 4	NC_000008	Reference
NM_001352694	2	mRNA	transcript variant 5	NC_000008	Reference
NM_001352695	2	mRNA	transcript variant 6	NC_000008	Reference
NM_001352696	2	mRNA	transcript variant 7	NC_000008	Reference
NM_001352697	2	mRNA	transcript variant 8	NC_000008	Reference
NM_001352698	2	mRNA	transcript variant 9	NC_000008	Reference
NM_001352699	2	mRNA	transcript variant 10	NC_000008	Reference
NM_001352700	2	mRNA	transcript variant 11	NC_000008	Reference
NM_001352701	2	mRNA	transcript variant 12	NC_000008	Reference

Showing 1 to 10 of 181 entries