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EPG5

ectopic P-granules 5 autophagy tethering factor
General Information
Name ectopic P-granules 5 autophagy tethering factor
Alias
  • ectopic P granules protein 5 homolog
  • ectopic P-granules autophagy protein 5 homolog
Gene_family
organism Homo sapiens
entrez_id 57724
location 18q12.3-q21.1
transcript_count 21
exon_count 46
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015]
    Stringdb Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo
    nextProt Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391).
Interactions
NCBI
StringDB
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0097352 Biological Process autophagosome maturation involved_in IBA
GO:1990786 Biological Process cellular response to dsDNA involved_in IMP
GO:0032456 Biological Process endocytic recycling involved_in IEA
GO:0008333 Biological Process endosome to lysosome transport involved_in IMP
GO:0006862 Biological Process nucleotide transport involved_in IMP
GO:0034162 Biological Process toll-like receptor 9 signaling pathway acts_upstream_of_positive_effect IMP
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005764 Cellular Component lysosome located_in IDA
GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IDA
Pathways
Name DB ID
Transcripts