BAX

BCL2 associated X, apoptosis regulator
General Information
Name BCL2 associated X, apoptosis regulator
Alias
  • apoptosis regulator BAX
  • BCL2 associated X protein
  • BCL2-associated X protein omega
  • Baxdelta2G9
  • Baxdelta2G9omega
  • Baxdelta2omega
  • bcl-2-like protein 4
  • bcl2-L-4
Synonyms BCL2L4
Gene_family BCL2 family
organism Homo sapiens
entrez_id 581
location 19q13.33
transcript_count 10
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]
      Stringdb Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family
      nextProt Plays a role in the mitochondrial apoptotic process (PubMed:10772918, PubMed:16113678, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816, PubMed:11060313, PubMed:16199525). Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis (PubMed:11060313, PubMed:16199525, PubMed:10772918, PubMed:16113678, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). Promotes activation of CASP3, and thereby apoptosis (PubMed:11060313, PubMed:16199525, PubMed:10772918, PubMed:16113678, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    BAX BioGRID TRIM17 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    BAX BioGRID UBE2H GeneID BioGRID Affinity Capture-MS
    BAX BioGRID MCL1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Dosage Rescue; Two-hybrid
    BAX BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    BAX BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    BAX BioGRID BAX GeneID BioGRID Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex; Two-hybrid
    BAX BioGRID BNIP3L GeneID BioGRID Negative Genetic
    BAX BioGRID BNIP3 GeneID BioGRID Negative Genetic
    BAX BioGRID BIK GeneID BioGRID Negative Genetic
    BAX BioGRID BID GeneID BioGRID Co-localization; Negative Genetic
    BAX BioGRID BAK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Negative Genetic
    BAX BioGRID BAD GeneID BioGRID Affinity Capture-Western; Negative Genetic
    BAX BioGRID BMF GeneID BioGRID Negative Genetic
    BAX BioGRID BCL2L12 GeneID BioGRID Affinity Capture-MS; Negative Genetic; Two-hybrid
    BAX BioGRID BCL2L14 GeneID BioGRID Negative Genetic
    BAX BioGRID USP12 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    BAX BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID RPN2 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID HSPA1A GeneID BioGRID Proximity Label-MS
    BAX BioGRID BAP1 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID ARL10 GeneID BioGRID Proximity Label-MS
    BAX BioGRID C9orf78 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID RIM11 GeneID BioGRID Synthetic Rescue
    BAX BioGRID BCL2L1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Dosage Rescue; FRET; Protein-peptide; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    BAX BioGRID FBXL20 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    BAX BioGRID BBC3 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID USP30 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID XRCC6 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID BCL2L15 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID BNIP5 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID BCL2L10 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    BAX BioGRID SMAD4 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID BCL2L2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    BAX BioGRID BCL2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    BAX BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
    BAX BioGRID PRKN GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    BAX BioGRID ITCH GeneID BioGRID Affinity Capture-Western
    BAX BioGRID MKRN2 GeneID BioGRID Affinity Capture-RNA
    BAX BioGRID WDR76 GeneID BioGRID Affinity Capture-MS; Co-purification
    BAX BioGRID COPS5 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID TP53 GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    BAX BioGRID SREBF2 GeneID BioGRID Negative Genetic
    BAX BioGRID MAP2K1 GeneID BioGRID Two-hybrid
    BAX BioGRID OCIAD1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    BAX BioGRID LEF1 GeneID BioGRID Two-hybrid
    BAX BioGRID ANP32B GeneID BioGRID Two-hybrid
    BAX BioGRID HSCB GeneID BioGRID Affinity Capture-MS
    BAX BioGRID SLC25A46 GeneID BioGRID Proximity Label-MS
    BAX BioGRID MAPK8 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID HSF2BP GeneID BioGRID Two-hybrid
    BAX BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
    BAX BioGRID CLUAP1 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID UVRAG GeneID BioGRID Affinity Capture-MS
    BAX BioGRID GUK1 GeneID BioGRID Co-fractionation
    BAX BioGRID FCGRT GeneID BioGRID Co-fractionation
    BAX BioGRID GSTK1 GeneID BioGRID Co-fractionation
    BAX BioGRID LONRF3 GeneID BioGRID Co-fractionation
    BAX BioGRID TXN2 GeneID BioGRID Co-fractionation
    BAX BioGRID HIV2gp4 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID ANAPC4 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID VIRMA GeneID BioGRID Affinity Capture-MS
    BAX BioGRID VDAC1 GeneID BioGRID Co-purification; Reconstituted Complex
    BAX BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID RNF4 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID FGFR1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    BAX BioGRID TRIM14 GeneID BioGRID Proximity Label-MS
    BAX BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
    BAX BioGRID ND5 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID HSD17B10 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID PPM1J GeneID BioGRID Affinity Capture-MS
    BAX BioGRID C15orf48 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID COQ9 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID SNCA GeneID BioGRID Co-localization
    BAX BioGRID SERPINB12 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID C18orf21 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID ATAD5 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID NSFL1C GeneID BioGRID Affinity Capture-MS
    BAX BioGRID BDP1 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID NIN GeneID BioGRID Affinity Capture-MS
    BAX BioGRID EDRF1 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID PRSS23 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID PNPLA6 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID GEMIN2 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID YY1 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID LIG3 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID ERCC6 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID LRRK2 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID YWHAQ GeneID BioGRID Affinity Capture-Western; Dosage Rescue; Reconstituted Complex
    BAX BioGRID BCL2L11 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID PRDX2 GeneID BioGRID Co-fractionation
    BAX BioGRID PKM GeneID BioGRID Co-fractionation
    BAX BioGRID PCBP1 GeneID BioGRID Co-fractionation
    BAX BioGRID PRDX1 GeneID BioGRID Co-fractionation
    BAX BioGRID SEPTIN7 GeneID BioGRID Dosage Rescue
    BAX BioGRID SERPINH1 GeneID BioGRID Co-fractionation
    BAX BioGRID CDC10 GeneID BioGRID Dosage Rescue
    BAX BioGRID F1L GeneID BioGRID Co-localization
    BAX BioGRID GIMAP5 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID CYCS GeneID BioGRID Co-fractionation
    BAX BioGRID ZBTB24 GeneID BioGRID Reconstituted Complex
    BAX BioGRID CASP9 GeneID BioGRID Co-fractionation
    BAX BioGRID CASP8 GeneID BioGRID Co-fractionation
    BAX BioGRID CASP7 GeneID BioGRID Co-fractionation
    BAX BioGRID CASP3 GeneID BioGRID Co-fractionation
    BAX BioGRID CLU GeneID BioGRID Affinity Capture-Western
    BAX BioGRID BAG3 GeneID BioGRID Affinity Capture-MS
    BAX BioGRID YWHAB GeneID BioGRID Two-hybrid
    BAX BioGRID VCP GeneID BioGRID Affinity Capture-MS
    BAX BioGRID CRYAB GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    BAX BioGRID CRYAA GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    BAX BioGRID XIAP GeneID BioGRID Affinity Capture-Western
    BAX BioGRID KCNA3 GeneID BioGRID Reconstituted Complex
    BAX BioGRID HSPA4 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID XRCC5 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID HDAC6 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID PSMC5 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID PSMC3 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID PARK7 GeneID BioGRID Reconstituted Complex
    BAX BioGRID UHRF2 GeneID BioGRID Far Western
    BAX BioGRID RNF144B GeneID BioGRID Affinity Capture-Western
    BAX BioGRID OYE2 GeneID BioGRID Dosage Rescue; Phenotypic Enhancement; Phenotypic Suppression
    BAX BioGRID TOMM22 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID TOMM40 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID MEPCE GeneID BioGRID Affinity Capture-MS
    BAX Protein MOAP1 GeneID HPRD None
    BAX Protein BBC3 GeneID HPRD None
    BAX Protein PPP1CA GeneID HPRD None
    BAX Protein KCNA3 GeneID HPRD None
    BAX Protein SH3GLB1 GeneID HPRD None
    BAX Protein PMAIP1 GeneID HPRD None
    BAX Protein MCL1 GeneID HPRD None
    BAX Protein BCL2L10 GeneID HPRD None
    BAX Protein Q8IVG9 Protein HPRD None
    BAX Protein NOL3 GeneID HPRD None
    BAX Protein VDAC1 GeneID HPRD None
    BAX Protein BID GeneID HPRD None
    BAX Protein SFN GeneID HPRD None
    BAX Protein BCL2A1 GeneID HPRD None
    BAX Protein BAK1 GeneID HPRD None
    BAX Protein BCL2L1 GeneID HPRD None
    BAX Protein BCL2 GeneID HPRD None
    BAX Protein YWHAQ GeneID HPRD None
    BAX Protein SLC25A4 GeneID HPRD None
    BAX BioGRID MOAP1 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID SH3GLB1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    BAX BioGRID HSPD1 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID BCL2A1 GeneID BioGRID Reconstituted Complex; Two-hybrid
    BAX BioGRID SLC25A4 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    BAX BioGRID Bak1 GeneID BioGRID Affinity Capture-Western
    BAX BioGRID PMAIP1 GeneID BioGRID Affinity Capture-Western
    BAX Nucleotide TP53 GeneID BIND p53 interacts with bax promoter.
    BAX None None None BIND MAP-1 interacts with an unspecified isoform of Bax.
    BAX Nucleotide TP73 GeneID BIND p73-alpha interacts with BAX promoter.
    BAX Nucleotide TAF1 GeneID BIND TAF1 (TAFII250) interacts with the Bax promoter.
    BAX Nucleotide GTF2B GeneID BIND GTF2B (TFIIB) interacts with the Bax promoter.
    BAX Nucleotide TBP GeneID BIND TBP interacts with the Bax promoter.
    BAX Nucleotide TP53 GeneID BIND p53 interacts with the Bax promoter.
    BAX Nucleotide MUC1 GeneID BIND MUC1 C-ter interacts with the Bax promoter.
    BAX Protein NOL3 GeneID BIND ARC interacts with Bax.
    BAX Protein BCL2L1 GeneID BIND Bax interacts with Bcl-XL via its BH3 domain. This interaction was modeled on a demonstrated interaction between mouse Bax and human Bcl-XL.
    BAX Protein MOAP1 GeneID BIND Bax interacts with MAP-1 via its BH1, BH2, and BH3 domains. This interaction was modeled on a demonstrated interaction between mouse Bax and human MAP-1.
    BAX Protein BBC3 GeneID BIND Bax interacts with PUMA.
    BAX Protein BCL2L1 GeneID BIND Bax interacts with Bcl-xL.
    BAX Protein BCL2 GeneID BIND Bax interacts with Bcl-2.
    BAX Protein BID GeneID BIND Bax interacts with Bid.
    BAX None None None BIND An unspecified isoform of Bax interacts with SH3GLB1.
    BAX None None None BIND HalphaB-crystallin interacts with Bax.
    BAX None None None BIND HalphaA-crystallin interacts with Bax.
    BAX None None None BIND Bax interacts with Bcl-XL.
    BAX Nucleotide TP53 GeneID BIND p53 interacts with Bax.
    BAX Protein BCL2 GeneID BIND Bcl-2 interacts with Bax.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    BAX TICAM1 0 0 108 224 1 1
    BAX EDRF1 246 0 0 245 1 1
    BAX VCP 113 0 67 192 1 2
    BAX CAPN2 0 800 122 816 1 2
    BAX YWHAE 0 0 113 179 1 1
    BAX IL7R 0 0 308 323 1 1
    BAX CDC25C 0 0 229 228 1 1
    BAX SOD1 0 0 322 326 1 1
    BAX PRDX1 684 0 134 714 1 1
    BAX ERN2 0 0 159 173 1 1
    BAX IGFBP3 0 0 181 202 1 1
    BAX MFN1 0 0 322 506 1 1
    BAX GAP43 0 0 140 166 1 1
    BAX CD8A 0 0 173 173 1 1
    BAX CALR 0 0 167 205 1 1
    BAX BIK 0 0 500 499 1 1
    BAX TFAM 0 0 217 234 1 1
    BAX MMP2 0 0 391 390 1 1
    BAX PRKACB 0 800 0 800 1 1
    BAX CHEK1 0 0 235 235 1 1
    BAX DNTT 0 0 611 611 1 1
    BAX SNCA 430 0 165 503 1 2
    BAX NOS1 0 0 156 155 1 1
    BAX CASP1 0 0 300 416 1 2
    BAX CCNA2 0 0 294 299 1 1
    BAX TNFSF10 0 0 403 403 1 2
    BAX AIF1 0 0 156 169 1 1
    BAX HSPA1A 0 0 215 215 1 1
    BAX BOK 0 0 510 203 1 2
    BAX VRK2 270 0 0 276 1 1
    BAX MAP2K3 0 0 124 164 1 1
    BAX BCL2L11 885 900 772 997 1 1
    BAX NRF1 0 0 170 169 1 1
    BAX CYP19A1 0 0 242 241 1 1
    BAX GEMIN2 246 0 0 245 1 1
    BAX ITPR3 0 0 236 236 1 1
    BAX JUN 0 0 558 558 1 1
    BAX DAPK1 0 0 181 181 1 2
    BAX TAF1 0 900 0 900 1 1
    BAX HPGDS 0 0 211 211 1 1
    BAX HSP90AA1 0 0 285 284 1 2
    BAX COX4I1 0 0 363 378 1 1
    BAX TP73 0 900 81 904 1 2
    BAX PSEN1 0 0 165 169 1 2
    BAX HTRA2 0 0 392 428 1 1
    BAX SPG7 0 720 0 720 1 1
    BAX ACTB 0 0 606 622 1 1
    BAX INS 0 0 371 371 1 1
    BAX BNIP3 0 0 486 494 1 2
    BAX SQSTM1 0 0 283 282 1 2
    BAX SIRT3 0 0 232 241 1 2
    BAX MAPK3 0 0 342 350 1 2
    BAX MMP9 0 0 451 451 1 1
    BAX KEAP1 0 0 326 325 1 2
    BAX AR 0 0 261 273 1 1
    BAX PARP1 0 0 413 412 1 2
    BAX RHOA 0 0 170 174 1 1
    BAX BID 871 900 857 998 1 1
    BAX GSR 0 0 298 317 1 1
    BAX SPP1 0 0 166 165 1 1
    BAX CDKN1A 0 0 501 515 1 2
    BAX VPS28 0 0 0 159 1 1
    BAX NSFL1C 246 0 0 262 1 1
    BAX TIMP1 0 0 266 284 1 1
    BAX TNNI3 0 0 201 201 1 1
    BAX TOMM40 270 540 74 671 1 1
    BAX ESR2 0 0 249 261 1 1
    BAX BCL2L12 682 0 73 710 1 1
    BAX MLKL 0 0 260 260 1 1
    BAX TIMM17A 0 0 0 288 1 1
    BAX ICAM1 0 0 267 267 1 1
    BAX DNM2 0 0 0 301 1 1
    BAX H2AFX 0 0 232 251 1 1
    BAX TRADD 0 0 361 414 1 1
    BAX CDK6 0 0 252 263 1 1
    BAX SIRT6 0 0 181 205 1 1
    BAX BCL2L13 0 0 210 224 1 1
    BAX C8B 0 720 0 727 1 1
    BAX CDH1 0 0 325 325 1 1
    BAX BCL2L10 486 0 293 621 1 1
    BAX EP300 0 900 170 913 1 1
    BAX LEF1 154 0 66 176 1 1
    BAX LIG3 235 0 0 242 1 1
    BAX HKDC1 0 800 0 800 1 1
    BAX BIRC3 0 0 299 327 1 1
    BAX ANXA8 0 0 325 325 1 1
    BAX SMAD3 0 0 193 193 1 1
    BAX TP53AIP1 0 0 297 297 1 1
    BAX TNFRSF10A 0 0 391 390 1 1
    BAX MLLT4 0 720 0 720 1 1
    BAX MYLK 0 0 143 171 1 1
    BAX SNAI2 0 0 398 398 1 1
    BAX CARD17 0 0 0 200 1 1
    BAX CASP8 270 0 680 796 1 2
    BAX ALB 0 0 458 462 1 1
    BAX CCL2 0 0 262 262 1 2
    BAX ITGB1 0 0 134 152 1 1
    BAX CASP7 270 0 470 663 1 1
    BAX HSPA4 270 0 391 536 1 1
    BAX C9 0 720 0 720 1 1
    BAX EAF2 0 0 134 163 1 1
    BAX HSP90B1 0 0 180 179 1 1
    BAX PDCD4 0 0 199 199 1 1
    BAX CYP2E1 0 0 174 173 1 1
    BAX CAPS2 0 0 167 167 1 1
    BAX HSPB3 0 0 258 258 1 1
    BAX PPARA 0 0 231 243 1 1
    BAX ACHE 0 0 193 193 1 1
    BAX ITPR1 0 0 260 260 1 2
    BAX CASP9 270 0 739 834 1 1
    BAX HK1 0 800 72 806 1 1
    BAX NANOG 0 0 161 161 1 1
    BAX RNF144B 385 0 0 384 1 1
    BAX TRAF6 0 0 167 167 1 2
    BAX CHEK2 0 0 260 266 1 1
    BAX CYCS 270 900 759 981 1 1
    BAX MAPK9 0 0 232 250 1 2
    BAX PRTN3 0 0 233 232 1 1
    BAX EGF 0 0 283 282 1 1
    BAX SH3GLB1 677 0 142 711 1 2
    BAX BFAR 0 0 189 189 1 1
    BAX PTK2 0 0 147 185 1 1
    BAX MAPK8 270 900 394 952 1 2
    BAX GCLC 0 0 156 155 1 1
    BAX BRAF 0 0 161 161 1 1
    BAX MUT 0 0 202 202 1 1
    BAX FAM136A 275 0 0 275 1 1
    BAX GPX4 0 0 202 202 1 1
    BAX TNS1 0 0 178 207 1 1
    BAX DIABLO 0 900 559 954 1 1
    BAX CTGF 0 0 213 213 1 1
    BAX GRINA 0 0 96 161 1 1
    BAX P2RX7 0 0 63 150 1 1
    BAX MX2 0 0 0 235 1 1
    BAX PGAM5 0 0 418 428 1 1
    BAX NFE2L2 0 0 469 469 1 1
    BAX PPP1R13B 0 900 0 900 1 1
    BAX LMBR1L 270 0 0 270 1 1
    BAX PHLDA3 0 0 181 186 1 1
    BAX OPA1 0 0 102 288 1 1
    BAX PPIF 0 720 294 797 1 1
    BAX MAP2K1 154 0 142 243 1 1
    BAX C5 0 720 0 720 1 1
    BAX MFF 0 0 209 278 1 1
    BAX NOL3 213 0 83 248 1 1
    BAX CASP10 0 0 321 433 1 1
    BAX CAPZB 0 0 0 154 1 1
    BAX NOXA1 0 0 156 167 1 1
    BAX PARK7 270 0 142 381 1 1
    BAX MOAP1 270 0 233 416 1 1
    BAX MX1 0 0 66 255 1 1
    BAX TMBIM6 0 800 451 885 1 1
    BAX P4HB 0 0 108 159 1 2
    BAX TRAF2 0 0 321 321 1 1
    BAX BDP1 226 0 0 225 1 1
    BAX MYC 0 0 409 418 1 2
    BAX IL18 0 0 181 187 1 1
    BAX PARK2 114 800 145 848 1 1
    BAX PRSS23 259 0 0 258 1 1
    BAX IGF1R 0 0 260 260 1 1
    BAX BLOC1S1 0 0 53 154 1 1
    BAX ADAM10 0 720 0 720 1 1
    BAX ENSG00000279576 0 0 167 167 1 1
    BAX PPARGC1A 0 0 324 323 1 1
    BAX ERN1 270 0 501 627 1 2
    BAX XRCC6 874 900 359 991 1 1
    BAX SERPINH1 272 0 57 305 1 1
    BAX VDAC2 0 540 310 674 1 1
    BAX STAT3 0 0 421 437 1 2
    BAX GDNF 0 0 167 167 1 1
    BAX BRD7 270 0 0 286 1 1
    BAX JAK2 0 0 265 265 1 1
    BAX HDAC6 270 0 108 321 1 2
    BAX APAF1 0 900 718 987 1 1
    BAX CDH2 0 0 241 240 1 1
    BAX HSCB 270 0 0 270 1 1
    BAX PIN1 270 0 122 342 1 1
    BAX CYBA 0 0 113 164 1 1
    BAX CLU 753 0 411 850 1 2
    BAX RAF1 0 0 165 165 1 2
    BAX HK2 0 800 453 886 1 1
    BAX GUK1 118 0 0 163 1 1
    BAX DDIT3 0 0 517 517 1 2
    BAX CRADD 0 0 159 158 1 1
    BAX TNFRSF11B 0 0 144 178 1 1
    BAX SLC25A4 270 0 124 362 1 1
    BAX MAP1A 0 0 402 415 1 1
    BAX PRKACG 0 800 0 800 1 1
    BAX MYH14 0 0 538 538 1 1
    BAX TP53 728 900 681 991 1 2
    BAX MDM2 0 0 455 463 1 1
    BAX PRKCE 270 0 90 307 1 1
    BAX SLC2A1 0 0 153 152 1 1
    BAX FADD 0 0 470 494 1 2
    BAX MYD88 0 0 183 236 1 1
    BAX HTT 0 0 160 159 1 1
    BAX CFLAR 0 0 419 515 1 1
    BAX EGFR 0 0 325 325 1 1
    BAX CDK4 0 0 374 383 1 1
    BAX PIK3C3 0 0 215 266 1 2
    BAX MPO 0 0 193 193 1 1
    BAX UCP2 0 0 136 176 1 1
    BAX IL6 0 0 459 459 1 1
    BAX BCL2L2-PABPN1 0 540 505 622 1 1
    BAX STAT1 0 0 144 168 1 1
    BAX ENDOG 0 0 470 488 1 1
    BAX OCLN 0 0 157 156 1 1
    BAX TNFRSF1A 0 0 358 358 1 1
    BAX CXCR4 0 0 163 163 1 2
    BAX PIDD1 0 0 212 224 1 1
    BAX FKBP15 0 0 155 154 1 1
    BAX NOTCH1 0 0 206 206 1 1
    BAX PDCD5 0 0 213 222 1 1
    BAX MTOR 0 0 509 517 1 2
    BAX GIMAP5 270 0 0 282 1 1
    BAX CDK2 0 0 391 400 1 1
    BAX C7 0 720 0 724 1 1
    BAX MAP1LC3A 0 0 193 194 1 2
    BAX HRAS 0 0 211 211 1 1
    BAX CTNNB1 0 0 390 390 1 1
    BAX MSH6 0 0 161 161 1 1
    BAX PDCD7 0 0 134 152 1 1
    BAX EGR1 0 0 137 150 1 1
    BAX MFN2 0 0 433 586 1 2
    BAX APP 0 0 209 209 1 1
    BAX DNM3 0 0 0 235 1 1
    BAX COQ9 151 0 0 155 1 1
    BAX SIRT5 0 0 160 178 1 1
    BAX HIF1A 0 0 391 404 1 2
    BAX EDN1 0 0 155 154 1 1
    BAX BAG3 270 0 96 322 1 2
    BAX IL1B 0 0 465 469 1 1
    BAX SP1 0 0 153 166 1 1
    BAX CXCL8 0 0 269 269 1 1
    BAX KIAA1429 270 0 0 270 1 1
    BAX KLK3 0 0 184 183 1 1
    BAX TMBIM4 0 0 167 227 1 1
    BAX TLR4 0 0 322 321 1 1
    BAX SMAD2 0 0 211 211 1 1
    BAX SLC25A11 0 0 55 178 1 1
    BAX ATPAF1 282 0 0 282 1 1
    BAX GAPDH 0 0 594 608 1 2
    BAX TNFRSF25 0 0 167 167 1 1
    BAX MAP2K7 0 0 266 266 1 1
    BAX NOS2 0 0 195 195 1 1
    BAX CAPZA1 0 0 0 179 1 1
    BAX ABL1 0 0 151 150 1 1
    BAX GJB2 0 0 415 414 1 1
    BAX CASP6 0 0 365 493 1 1
    BAX NFKB1 0 0 173 202 1 1
    BAX BCL2L1 913 900 709 993 1 2
    BAX CCNB1 0 0 427 439 1 1
    BAX ANXA5 0 0 667 667 1 1
    BAX HSPD1 270 0 84 389 1 1
    BAX PERP 0 0 193 193 1 1
    BAX HES1 0 0 194 194 1 1
    BAX SIRT2 0 0 170 169 1 2
    BAX EPO 0 0 180 179 1 1
    BAX HSF1 0 0 243 251 1 1
    BAX CLUAP1 270 0 0 270 1 1
    BAX PRKACA 0 800 0 800 1 1
    BAX GDF9 0 0 202 202 1 1
    BAX PPID 0 0 150 164 1 1
    BAX SLC25A10 0 0 0 171 1 1
    BAX IFNG 0 0 181 190 1 2
    BAX BIRC2 0 0 321 348 1 1
    BAX CREB1 0 0 323 323 1 1
    BAX ZNF658 0 0 0 188 1 1
    BAX YWHAZ 0 0 161 164 1 1
    BAX FOS 0 0 242 241 1 1
    BAX FASLG 0 0 468 468 1 1
    BAX NELFB 0 900 0 905 1 1
    BAX BIRC7 0 0 240 270 1 1
    BAX HSPA5 0 0 459 459 1 2
    BAX E2F1 0 0 141 196 1 1
    BAX DNM1 0 0 53 245 1 1
    BAX CASP14 0 0 74 227 1 1
    BAX SERPINB12 151 0 0 150 1 1
    BAX HAX1 0 0 180 196 1 2
    BAX BTRC 0 0 107 175 1 1
    BAX NIN 168 0 0 167 1 1
    BAX KRAS 0 0 181 181 1 1
    BAX FOXO1 0 0 229 241 1 2
    BAX SOD2 0 0 369 369 1 1
    BAX CYP11A1 0 0 154 153 1 1
    BAX ABCB1 0 0 215 215 1 1
    BAX TMBIM1 0 0 124 187 1 1
    BAX BECN1 0 0 504 621 1 2
    BAX ABCC1 0 0 167 212 1 1
    BAX SNAPIN 0 0 0 210 1 1
    BAX OLR1 0 0 157 156 1 1
    BAX IL2 0 0 164 163 1 1
    BAX PMAIP1 270 0 603 730 1 1
    BAX PEA15 0 0 108 256 1 1
    BAX AMH 0 0 202 202 1 1
    BAX LRRK2 270 0 49 309 1 2
    BAX GFM2 0 0 0 160 1 1
    BAX PDZD11 0 720 0 720 1 1
    BAX SEPT2 0 0 0 162 1 1
    BAX TRIB3 0 0 138 155 1 1
    BAX NLRP3 0 0 181 181 1 2
    BAX CARD16 0 0 0 200 1 1
    BAX PRELID1 0 0 0 199 1 1
    BAX TNFRSF21 0 0 202 202 1 1
    BAX PTGS2 0 0 458 457 1 1
    BAX NQO1 0 0 322 321 1 1
    BAX CASP3 270 0 841 899 1 2
    BAX CHP2 0 0 165 178 1 1
    BAX ATG12 0 0 180 179 1 2
    BAX TNFRSF10B 0 0 456 472 1 1
    BAX CYBB 0 0 261 267 1 1
    BAX SEPT7 209 0 0 311 1 1
    BAX PPIA 0 0 126 169 1 1
    BAX CASP4 0 0 246 371 1 2
    BAX CDKN2A 0 0 267 294 1 2
    BAX RPS27A 270 0 0 284 1 1
    BAX SFN 270 600 241 759 1 1
    BAX CCNG1 0 0 159 177 1 1
    BAX MTCH2 0 0 195 195 1 1
    BAX GSK3B 270 0 301 477 1 2
    BAX XRCC5 270 0 73 294 1 1
    BAX RBL2 0 0 103 177 1 1
    BAX TSPO 0 0 145 166 1 1
    BAX LAMA2 0 0 398 398 1 1
    BAX SMPD1 0 0 435 435 1 1
    BAX TOMM22 270 0 122 332 1 1
    BAX CRYAB 270 0 57 282 1 1
    BAX HDAC1 0 0 154 170 1 2
    BAX RIPK1 0 0 320 319 1 1
    BAX SNAI1 0 0 183 183 1 1
    BAX IL10 0 0 278 278 1 1
    BAX TGFBR2 0 0 195 195 1 1
    BAX TJP1 0 0 167 167 1 1
    BAX ATG7 0 0 266 287 1 2
    BAX FAIM2 0 0 134 196 1 1
    BAX PLEKHA7 0 720 0 724 1 1
    BAX MDM4 0 0 167 180 1 1
    BAX TNFRSF10C 0 0 150 185 1 1
    BAX CTSD 0 0 149 170 1 2
    BAX ATM 0 0 325 332 1 1
    BAX KCNA3 486 0 0 485 1 1
    BAX PSMC3 270 0 0 270 1 1
    BAX MAPK14 0 0 233 232 1 1
    BAX MAPK10 0 0 193 205 1 2
    BAX BAG1 0 0 181 193 1 2
    BAX TP53BP2 0 900 83 904 1 1
    BAX SREBF1 0 0 183 183 1 2
    BAX TCF4 0 0 213 213 1 1
    BAX C12orf5 0 0 150 173 1 1
    BAX NFKBIA 0 0 369 378 1 1
    BAX KIT 0 0 155 154 1 1
    BAX CASP5 0 0 96 246 1 1
    BAX DNM1L 0 0 686 750 1 2
    BAX NTRK3 0 900 45 900 1 1
    BAX VEGFA 0 0 467 467 1 1
    BAX TXN2 115 0 107 189 1 1
    BAX PTEN 0 0 401 422 1 2
    BAX TP63 0 900 0 900 1 2
    BAX XBP1 0 0 396 396 1 2
    BAX MANF 0 0 134 173 1 1
    BAX ATG5 0 0 325 345 1 2
    BAX BCL2L14 0 0 157 156 1 1
    BAX EPB41L4A 0 0 0 152 1 1
    BAX ERCC6 235 0 0 248 1 1
    BAX PSMC5 270 0 0 270 1 1
    BAX MAP3K5 0 0 392 392 1 1
    BAX DUOX2 0 0 163 169 1 1
    BAX HMGB1 0 0 233 250 1 2
    BAX PPP1CA 128 0 0 223 1 1
    BAX TSPAN33 0 720 0 720 1 1
    BAX ESR1 0 0 324 335 1 1
    BAX CTSB 0 0 183 189 1 2
    BAX LMNB1 0 0 150 171 1 1
    BAX SIRT1 0 900 401 937 1 2
    BAX MCL1 978 900 630 998 1 2
    BAX HSPB4 270 0 0 270 1 1
    BAX PCBP1 272 0 0 275 1 1
    BAX FN1 0 0 242 241 1 1
    BAX GPX1 0 0 217 239 1 1
    BAX IKBKG 0 0 155 176 1 1
    BAX ULK1 0 0 203 209 1 2
    BAX SPHK2 0 0 411 411 1 1
    BAX TIMP2 0 0 180 179 1 1
    BAX DFFB 0 0 261 261 1 1
    BAX MAP1LC3B 0 0 376 377 1 2
    BAX TSG101 0 0 49 178 1 2
    BAX HSPB1 0 0 235 235 1 1
    BAX CASP16 0 0 0 200 1 1
    BAX C18orf21 246 0 0 245 1 1
    BAX HSPB2 0 0 218 218 1 1
    BAX TERT 0 0 162 161 1 1
    BAX UVRAG 486 0 134 535 1 2
    BAX IGF1 0 0 340 340 1 1
    BAX MAPK1 0 0 193 224 1 2
    BAX ATF3 0 0 155 154 1 1
    BAX GADD45A 0 0 284 284 1 1
    BAX PKM 272 0 101 361 1 1
    BAX BMF 0 0 421 486 1 1
    BAX BCL2A1 270 0 369 519 1 1
    BAX DRAM1 0 0 264 270 1 2
    BAX BCAP31 0 0 155 165 1 1
    BAX FGF2 0 0 262 262 1 1
    BAX C8G 0 540 0 540 1 1
    BAX GCG 0 0 166 165 1 1
    BAX PRDX2 611 0 84 628 1 1
    BAX PPP1R15A 0 0 185 191 1 2
    BAX RBFOX3 0 0 154 153 1 1
    BAX PNPLA6 151 0 74 198 1 1
    BAX PDCD6IP 0 0 141 167 1 1
    BAX NAIP 0 0 161 194 1 1
    BAX FIS1 0 0 290 314 1 2
    BAX MMP3 0 0 176 175 1 1
    BAX C6 0 720 52 730 1 1
    BAX CASP2 0 0 369 473 1 1
    BAX AEN 0 0 193 233 1 1
    BAX BDNF 0 0 375 375 1 2
    BAX CD44 0 0 167 167 1 1
    BAX IL7 0 0 305 305 1 1
    BAX DMPK 0 0 416 416 1 1
    BAX C22orf29 270 0 469 595 1 1
    BAX RNF4 270 0 0 283 1 1
    BAX TNF 0 0 457 467 1 1
    BAX CYC1 0 0 158 159 1 1
    BAX CAT 0 0 518 518 1 1
    BAX PECAM1 0 0 171 178 1 1
    BAX POU5F1 0 0 193 212 1 1
    BAX HGF 0 0 170 169 1 1
    BAX CANX 0 0 141 265 1 2
    BAX TXN 0 0 218 231 1 1
    BAX HRK 0 0 391 390 1 1
    BAX CCNE1 0 0 163 163 1 1
    BAX BCL2 981 900 758 998 1 2
    BAX RPA1 0 900 70 905 1 1
    BAX BAK1 753 900 732 981 1 2
    BAX MRPS12 0 0 721 726 1 1
    BAX CARD18 0 0 82 234 1 1
    BAX DFFA 0 0 218 218 1 1
    BAX MT-ND5 270 0 45 273 1 1
    BAX STAR 0 0 218 218 1 1
    BAX NOS3 0 0 358 358 1 1
    BAX TNFRSF10D 0 0 155 173 1 1
    BAX CCND1 0 0 519 519 1 1
    BAX FSHR 0 0 166 165 1 1
    BAX ATR 0 0 181 195 1 1
    BAX BCL2L2 877 540 527 951 1 1
    BAX HK3 0 800 0 800 1 1
    BAX NCF1 0 0 155 154 1 1
    BAX FAU 0 0 0 163 1 1
    BAX C8A 0 720 0 732 1 1
    BAX ABCG2 0 0 185 185 1 1
    BAX HSPA9 0 0 160 159 1 1
    BAX EFS 0 0 290 290 1 1
    BAX IRS1 0 0 195 195 1 1
    BAX IFT43 0 0 384 384 1 1
    BAX LEPREL2 0 0 523 523 1 1
    BAX CDK1 0 0 337 347 1 1
    BAX PGR 0 0 150 164 1 1
    BAX YWHAQ 461 0 49 488 1 1
    BAX RPS6KB1 0 0 299 299 1 2
    BAX BAD 419 0 681 845 1 1
    BAX TOMM40L 0 540 0 540 1 1
    BAX EIF2AK3 0 0 415 414 1 2
    BAX ZBTB24 270 0 0 281 1 1
    BAX FLT1 0 0 168 167 1 1
    BAX ATG3 0 0 183 188 1 2
    BAX BIRC6 0 0 165 207 1 1
    BAX OCIAD1 406 0 0 406 1 1
    BAX CDKN3 0 0 328 339 1 1
    BAX ATAD5 151 0 0 150 1 1
    BAX SRC 0 0 261 261 1 1
    BAX DAP3 0 0 181 195 1 1
    BAX FOXO3 0 0 338 349 1 2
    BAX VDAC3 0 540 247 644 1 1
    BAX CBFB 0 900 0 900 1 1
    BAX PCSK9 0 0 181 181 1 1
    BAX YWHAB 192 0 90 295 1 1
    BAX CDKN1B 0 0 240 239 1 2
    BAX RIPK3 0 0 261 261 1 1
    BAX RB1 0 0 234 297 1 2
    BAX TGFB1 0 0 232 260 1 1
    BAX VDAC1 866 800 538 986 1 2
    BAX BNIP3L 0 0 180 192 1 2
    BAX KDR 0 0 181 181 1 2
    BAX EIF2S1 0 0 260 260 1 2
    BAX TOMM20 161 0 140 264 1 1
    BAX YY1 135 0 57 162 1 1
    BAX TCHP 0 0 508 508 1 1
    BAX HMOX1 0 0 503 514 1 2
    BAX RUNX2 0 900 194 915 1 1
    BAX XIAP 270 0 517 647 1 1
    BAX ANP32B 154 0 0 153 1 1
    BAX NOX4 0 0 170 176 1 1
    BAX DUOX1 0 0 167 173 1 1
    BAX IKBKB 0 0 175 175 1 1
    BAX ATF6 0 0 379 379 1 2
    BAX DCTN5 0 0 0 158 1 1
    BAX VCAM1 0 0 167 187 1 1
    BAX ATF4 0 0 395 394 1 2
    BAX CD4 0 0 174 183 1 1
    BAX FAS 0 0 452 452 1 2
    BAX CARD8 0 0 45 203 1 1
    BAX UBR4 0 0 0 154 1 1
    BAX PPARG 0 0 322 333 1 1
    BAX CAPN1 0 800 181 829 1 2
    BAX AKT1 270 0 682 763 1 2
    BAX TH 0 0 180 197 1 1
    BAX DENR 0 0 155 269 1 1
    BAX BBC3 213 0 666 739 1 1
    BAX IRF3 270 0 415 578 1 1
    BAX ERBB2 0 0 245 244 1 2
    BAX CD34 0 720 155 753 1 1
    BAX NGF 0 0 282 282 1 1
    BAX ANAPC4 270 0 0 278 1 1
    BAX AIFM1 0 900 124 917 1 1
    BAX PYCARD 270 0 128 364 1 1
    BAX YME1L1 0 0 0 288 1 1
    BAX TYMS 0 0 150 169 1 1
    BAX EIF4EBP1 0 0 228 256 1 1
    BAX C15orf48 275 0 0 284 1 1
    BAX BIRC5 0 0 181 213 1 2
    BAX SIRT4 0 0 166 165 1 1
    BAX CLGN 0 0 0 163 1 1
    BAX PINK1 0 0 210 318 1 2
    BAX GPT 0 0 294 294 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0051434 Molecular Function BH3 domain binding enables IDA
    GO:0051434 Molecular Function BH3 domain binding enables IPI
    GO:0030544 Molecular Function Hsp70 protein binding enables IEA
    GO:0015267 Molecular Function channel activity enables IBA
    GO:0015267 Molecular Function channel activity enables IDA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0008289 Molecular Function lipid binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0046982 Molecular Function protein heterodimerization activity enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IDA
    GO:0001783 Biological Process B cell apoptotic process involved_in IDA
    GO:0001782 Biological Process B cell homeostasis involved_in IEA
    GO:0002358 Biological Process B cell homeostatic proliferation involved_in IEA
    GO:0002352 Biological Process B cell negative selection involved_in IEA
    GO:1990117 Biological Process B cell receptor apoptotic signaling pathway involved_in IDA
    GO:0060011 Biological Process Sertoli cell proliferation involved_in IEA
    GO:0001777 Biological Process T cell homeostatic proliferation involved_in IEA
    GO:0008637 Biological Process apoptotic mitochondrial changes involved_in IDA
    GO:0006915 Biological Process apoptotic process involved_in IDA
    GO:0006915 Biological Process apoptotic process involved_in IMP
    GO:0006915 Biological Process apoptotic process involved_in NAS
    GO:1902262 Biological Process apoptotic process involved in blood vessel morphogenesis involved_in IEA
    GO:1902263 Biological Process apoptotic process involved in embryonic digit morphogenesis involved_in IEA
    GO:0060057 Biological Process apoptotic process involved in mammary gland involution involved_in IEA
    GO:0097190 Biological Process apoptotic signaling pathway involved_in IDA
    GO:0001974 Biological Process blood vessel remodeling involved_in IEA
    GO:0060402 Biological Process calcium ion transport into cytosol involved_in IEA
    GO:0034644 Biological Process cellular response to UV involved_in IEA
    GO:0034620 Biological Process cellular response to unfolded protein involved_in TAS
    GO:0098586 Biological Process cellular response to virus involved_in IDA
    GO:0021987 Biological Process cerebral cortex development involved_in IEA
    GO:0045136 Biological Process development of secondary sexual characteristics involved_in IEA
    GO:0035234 Biological Process ectopic germ cell programmed cell death involved_in IEA
    GO:0032469 Biological Process endoplasmic reticulum calcium ion homeostasis involved_in TAS
    GO:1904019 Biological Process epithelial cell apoptotic process involved_in IEA
    GO:0010248 Biological Process establishment or maintenance of transmembrane electrochemical gradient involved_in IDA
    GO:0097194 Biological Process execution phase of apoptosis involved_in IMP
    GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IDA
    GO:0097192 Biological Process extrinsic apoptotic signaling pathway in absence of ligand involved_in IBA
    GO:0008625 Biological Process extrinsic apoptotic signaling pathway via death domain receptors involved_in IC
    GO:0009566 Biological Process fertilization involved_in IEA
    GO:0007281 Biological Process germ cell development involved_in IEA
    GO:0006687 Biological Process glycosphingolipid metabolic process involved_in IEA
    GO:0048873 Biological Process homeostasis of number of cells within a tissue involved_in IEA
    GO:0021854 Biological Process hypothalamus development involved_in IEA
    GO:0097193 Biological Process intrinsic apoptotic signaling pathway involved_in IDA
    GO:0072332 Biological Process intrinsic apoptotic signaling pathway by p53 class mediator involved_in IEA
    GO:0008630 Biological Process intrinsic apoptotic signaling pathway in response to DNA damage involved_in IBA
    GO:0008630 Biological Process intrinsic apoptotic signaling pathway in response to DNA damage involved_in IDA
    GO:0070059 Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress involved_in TAS
    GO:0001822 Biological Process kidney development involved_in IEA
    GO:0043653 Biological Process mitochondrial fragmentation involved in apoptotic process involved_in IDA
    GO:0008053 Biological Process mitochondrial fusion involved_in IBA
    GO:0008053 Biological Process mitochondrial fusion involved_in IDA
    GO:0097049 Biological Process motor neuron apoptotic process involved_in IEA
    GO:0002262 Biological Process myeloid cell homeostasis involved_in IEA
    GO:2001234 Biological Process negative regulation of apoptotic signaling pathway involved_in IEA
    GO:0032471 Biological Process negative regulation of endoplasmic reticulum calcium ion concentration involved_in IEA
    GO:0048147 Biological Process negative regulation of fibroblast proliferation involved_in IEA
    GO:0010917 Biological Process negative regulation of mitochondrial membrane potential involved_in IDA
    GO:0043524 Biological Process negative regulation of neuron apoptotic process involved_in IEA
    GO:0032091 Biological Process negative regulation of protein binding involved_in IDA
    GO:0001764 Biological Process neuron migration involved_in IEA
    GO:0042475 Biological Process odontogenesis of dentin-containing tooth involved_in IEA
    GO:0001541 Biological Process ovarian follicle development involved_in IEA
    GO:0002904 Biological Process positive regulation of B cell apoptotic process involved_in IEA
    GO:1903896 Biological Process positive regulation of IRE1-mediated unfolded protein response involved_in TAS
    GO:1902512 Biological Process positive regulation of apoptotic DNA fragmentation involved_in IMP
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IMP
    GO:0060058 Biological Process positive regulation of apoptotic process involved in mammary gland involution involved_in IEA
    GO:0010524 Biological Process positive regulation of calcium ion transport into cytosol involved_in IEA
    GO:0048087 Biological Process positive regulation of developmental pigmentation involved_in IEA
    GO:1904037 Biological Process positive regulation of epithelial cell apoptotic process involved_in IEA
    GO:2001244 Biological Process positive regulation of intrinsic apoptotic signaling pathway involved_in IMP
    GO:1902110 Biological Process positive regulation of mitochondrial membrane permeability involved in apoptotic process involved_in IEA
    GO:2000673 Biological Process positive regulation of motor neuron apoptotic process involved_in IEA
    GO:0043525 Biological Process positive regulation of neuron apoptotic process involved_in IBA
    GO:0043525 Biological Process positive regulation of neuron apoptotic process involved_in IDA
    GO:0031334 Biological Process positive regulation of protein-containing complex assembly involved_in IDA
    GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in IDA
    GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in IMP
    GO:0051281 Biological Process positive regulation of release of sequestered calcium ion into cytosol involved_in IEA
    GO:2000243 Biological Process positive regulation of reproductive process involved_in IEA
    GO:0048597 Biological Process post-embryonic camera-type eye morphogenesis involved_in IEA
    GO:0051204 Biological Process protein insertion into mitochondrial membrane involved_in IEA
    GO:0042981 Biological Process regulation of apoptotic process involved_in IDA
    GO:0051726 Biological Process regulation of cell cycle involved_in IEA
    GO:0033599 Biological Process regulation of mammary gland epithelial cell proliferation involved_in IEA
    GO:1902445 Biological Process regulation of mitochondrial membrane permeability involved in programmed necrotic cell death involved_in IEA
    GO:0051881 Biological Process regulation of mitochondrial membrane potential involved_in IDA
    GO:0006808 Biological Process regulation of nitrogen utilization involved_in IEA
    GO:0001836 Biological Process release of cytochrome c from mitochondria involved_in IBA
    GO:0001836 Biological Process release of cytochrome c from mitochondria involved_in IDA
    GO:0032976 Biological Process release of matrix enzymes from mitochondria involved_in IDA
    GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IEA
    GO:0048678 Biological Process response to axon injury involved_in IEA
    GO:0010332 Biological Process response to gamma radiation involved_in IEA
    GO:0009651 Biological Process response to salt stress involved_in IEA
    GO:0009636 Biological Process response to toxic substance involved_in IDA
    GO:0060041 Biological Process retina development in camera-type eye involved_in IEA
    GO:0046666 Biological Process retinal cell programmed cell death involved_in IEA
    GO:0048515 Biological Process spermatid differentiation involved_in IEA
    GO:0097435 Biological Process supramolecular fiber organization involved_in IDA
    GO:0070242 Biological Process thymocyte apoptotic process involved_in IEA
    GO:0060068 Biological Process vagina development involved_in IEA
    GO:0097145 Cellular Component BAK complex part_of IDA
    GO:0097144 Cellular Component BAX complex part_of IDA
    GO:0097136 Cellular Component Bcl-2 family protein complex part_of IDA
    GO:0071944 Cellular Component cell periphery colocalizes_with IDA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IDA
    GO:0070062 Cellular Component extracellular exosome located_in HDA
    GO:0016020 Cellular Component membrane located_in HDA
    GO:0005741 Cellular Component mitochondrial outer membrane is_active_in IBA
    GO:0005741 Cellular Component mitochondrial outer membrane located_in IDA
    GO:0005741 Cellular Component mitochondrial outer membrane located_in TAS
    GO:0005757 Cellular Component mitochondrial permeability transition pore complex part_of IDA
    GO:0005739 Cellular Component mitochondrion located_in HTP
    GO:0005739 Cellular Component mitochondrion located_in IDA
    GO:0005635 Cellular Component nuclear envelope located_in IDA
    GO:0005634 Cellular Component nucleus located_in IDA
    GO:0005634 Cellular Component nucleus located_in IMP
    GO:0046930 Cellular Component pore complex part_of IDA
    Pathways
    Name DB ID
    Apoptosis Reactome R-HSA-109581
    Intrinsic Pathway for Apoptosis Reactome R-HSA-109606
    Release of apoptotic factors from the mitochondria Reactome R-HSA-111457
    Apoptotic factor-mediated response Reactome R-HSA-111471
    Activation, translocation and oligomerization of BAX Reactome R-HSA-114294
    Signal Transduction Reactome R-HSA-162582
    Signaling by NTRKs Reactome R-HSA-166520
    Generic Transcription Pathway Reactome R-HSA-212436
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    Regulated Necrosis Reactome R-HSA-5218859
    Programmed Cell Death Reactome R-HSA-5357801
    Pyroptosis Reactome R-HSA-5620971
    TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
    TP53 Regulates Transcription of Cell Cycle Genes Reactome R-HSA-6791312
    TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome R-HSA-6803204
    TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Reactome R-HSA-6804114
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    Transcriptional regulation by RUNX2 Reactome R-HSA-8878166
    Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
    Signaling by NTRK3 (TRKC) Reactome R-HSA-9034015
    NTRK3 as a dependence receptor Reactome R-HSA-9603505
    Peroxiredoxin 2 induced ovarian failure (WP4873) WikiPathways WP4873_r110299
    DNA IR-double strand breaks and cellular response via ATM (WP3959) WikiPathways WP3959_r118468
    Photodynamic therapy-induced HIF-1 survival signaling (WP3614) WikiPathways WP3614_r106542
    Integrated cancer pathway (WP1971) WikiPathways WP1971_r117762
    p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
    Chromosomal and microsatellite instability in colorectal cancer (WP4216) WikiPathways WP4216_r123363
    Measles virus infection (WP4630) WikiPathways WP4630_r123414
    Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
    Nanomaterial induced apoptosis (WP2507) WikiPathways WP2507_r123897
    Complement system in neuronal development and plasticity (WP5090) WikiPathways WP5090_r118898
    Breast cancer pathway (WP4262) WikiPathways WP4262_r123349
    EGFR tyrosine kinase inhibitor resistance (WP4806) WikiPathways WP4806_r123492
    Melanoma (WP4685) WikiPathways WP4685_r123437
    Amyotrophic lateral sclerosis (ALS) (WP2447) WikiPathways WP2447_r113794
    miRNA regulation of p53 pathway in prostate cancer (WP3982) WikiPathways WP3982_r108115
    Burn wound healing (WP5055) WikiPathways WP5055_r122621
    Overview of nanoparticle effects (WP3287) WikiPathways WP3287_r121705
    IL-18 signaling pathway (WP4754) WikiPathways WP4754_r115147
    Acute viral myocarditis (WP4298) WikiPathways WP4298_r123508
    Nuclear receptors meta-pathway (WP2882) WikiPathways WP2882_r120815
    DNA damage response (only ATM dependent) (WP710) WikiPathways WP710_r116542
    Leptin signaling pathway (WP2034) WikiPathways WP2034_r120670
    Regulation of apoptosis by parathyroid hormone-related protein (WP3872) WikiPathways WP3872_r123397
    Small cell lung cancer (WP4658) WikiPathways WP4658_r124606
    Aryl hydrocarbon receptor pathway (WP2873) WikiPathways WP2873_r123110
    RAC1/PAK1/p38/MMP2 pathway (WP3303) WikiPathways WP3303_r123243
    Host-pathogen interaction of human coronaviruses - apoptosis (WP4864) WikiPathways WP4864_r124634
    DNA damage response (WP707) WikiPathways WP707_r124174
    TP53 network (WP1742) WikiPathways WP1742_r116592
    Mammary gland development pathway - Involution (Stage 4 of 4) (WP2815) WikiPathways WP2815_r102408
    Apoptosis (WP254) WikiPathways WP254_r118382
    Pro-survival signaling of neuroprotectin D1 (WP5182) WikiPathways WP5182_r122168
    Nonalcoholic fatty liver disease (WP4396) WikiPathways WP4396_r123350
    Pancreatic adenocarcinoma pathway (WP4263) WikiPathways WP4263_r123405
    Photodynamic therapy-induced AP-1 survival signaling (WP3611) WikiPathways WP3611_r120501
    TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
    Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
    Non-small cell lung cancer (WP4255) WikiPathways WP4255_r123348
    Regucalcin in proximal tubule epithelial kidney cells (WP4838) WikiPathways WP4838_r110282
    Endometrial cancer (WP4155) WikiPathways WP4155_r123347
    miRNA regulation of DNA damage response (WP1530) WikiPathways WP1530_r124175
    Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
    T-cell activation SARS-CoV-2 (WP5098) WikiPathways WP5098_r119538
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_027882 2 miscRNA transcript variant epsilon NC_000019 Reference
    NM_004324 4 mRNA transcript variant beta NC_000019 Reference
    NM_001291428 2 mRNA transcript variant 1 NC_000019 Reference
    NM_138761 4 mRNA transcript variant alpha NC_000019 Reference
    NM_138764 5 mRNA transcript variant sigma NC_000019 Reference
    NM_138763 4 mRNA transcript variant delta NC_000019 Reference
    NM_001291429 2 mRNA transcript variant gamma NC_000019 Reference
    NM_001291430 2 mRNA transcript variant lambda NC_000019 Reference
    NM_001291431 2 mRNA transcript variant zeta NC_000019 Reference
    XM_047439168 1 mRNA transcript variant X1 NC_000019 Reference