NLRC4

NLR family CARD domain containing 4
General Information
Name NLR family CARD domain containing 4
Alias
  • NLR family CARD domain-containing protein 4
  • CARD, LRR, and NACHT-containing protein
  • CED-4-like protein Clan
  • ICE-protease activating factor
  • NOD-like receptor C4
  • caspase recruitment domain family, member 12
  • caspase recruitment domain-containing protein 12
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Synonyms CLAN1 ipaf CLANA CLANB CLANC CLAND CLR2.1 CLAN AIFEC CARD12 FCAS4 IPAF
Gene_family NLR family|Caspase recruitment domain containing
organism Homo sapiens
entrez_id 58484
location 2p22.3
transcript_count 5
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
      Stringdb NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis; Caspase recruitment domain containing
      nextProt Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    NLRC4 BioGRID FOXP1 GeneID BioGRID Protein-RNA
    NLRC4 BioGRID RPSA GeneID BioGRID Cross-Linking-MS (XL-MS)
    NLRC4 BioGRID EFNA3 GeneID BioGRID Affinity Capture-MS
    NLRC4 BioGRID TRIM65 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID FADD GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID PSMC5 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    NLRC4 BioGRID CASP8 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID XK GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID ALB GeneID BioGRID Affinity Capture-MS
    NLRC4 BioGRID NLRC4 GeneID BioGRID Affinity Capture-Western
    NLRC4 Protein NLRP4 GeneID HPRD None
    NLRC4 Protein PYCARD GeneID HPRD None
    NLRC4 Protein NOD2 GeneID HPRD None
    NLRC4 Protein BCL10 GeneID HPRD None
    NLRC4 Protein CASP1 GeneID HPRD None
    NLRC4 BioGRID PYCARD GeneID BioGRID Two-hybrid
    NLRC4 BioGRID NOD2 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID NLRP1 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID BCL10 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID CASP1 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID NLRP3 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID NOD1 GeneID BioGRID Affinity Capture-Western
    NLRC4 BioGRID NAIP GeneID BioGRID Affinity Capture-Western
    NLRC4 Protein BCL10 GeneID BIND CARD12 (CLAN) interacts with Bcl10. This interaction was modelled on a demonstrated interaction between human CARD12 and Bcl10 from an unspecified species.
    NLRC4 Protein CASP1 GeneID BIND CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.
    NLRC4 Protein NLRP3 GeneID BIND CARD12 (CLAN) interacts with an unspecified isoform of CIAS1 (cryopyrin). This interaction was modelled on a demonstrated interaction between human CARD12 and CIAS1 from an unspecified species.
    NLRC4 Protein NAIP GeneID BIND CARD12 (CLAN) interacts with BIRC1 (NAIP). This interaction was modelled on a demonstrated interaction between human CARD12 and BIRC1 from an unspecified species.
    NLRC4 Protein NOD1 GeneID BIND CARD12 (CLAN) interacts with CARD4 (Nod1).
    NLRC4 Protein NLRP4 GeneID BIND CARD12 (CLAN) interacts with NALP4 (PAN2).
    NLRC4 Protein NLRP1 GeneID BIND CARD12 (CLAN) interacts with NALP1 (NAC).
    NLRC4 Protein NOD2 GeneID BIND CARD12 (CLAN) interacts with CARD15 (Nod2).
    NLRC4 Protein NLRC4 GeneID BIND CARD12 (CLAN) interacts with CARD12 (CLAN).
    StringDB
    A B experiments database textmining combined score hadb nhadb
    NLRC4 FAS 0 0 146 166 1 2
    NLRC4 DPEP2 0 0 0 155 1 1
    NLRC4 CASP6 0 0 163 227 1 1
    NLRC4 TAB3 0 0 162 161 1 2
    NLRC4 F13A1 0 0 0 245 1 1
    NLRC4 CARD14 0 0 216 216 1 1
    NLRC4 CARD8 0 720 538 875 1 1
    NLRC4 DHRS7C 0 0 120 156 1 1
    NLRC4 CLEC7A 0 0 470 536 1 1
    NLRC4 TLR10 0 0 294 352 1 1
    NLRC4 TRIM25 0 0 144 162 1 1
    NLRC4 PIK3R4 0 0 146 177 1 2
    NLRC4 PTPN14 0 0 0 210 1 1
    NLRC4 MBTPS1 0 0 322 321 1 1
    NLRC4 CD4 0 0 455 501 1 1
    NLRC4 BCL2L1 0 0 180 179 1 2
    NLRC4 AAMP 0 0 124 211 1 1
    NLRC4 AKT1 0 0 251 250 1 2
    NLRC4 CYTH4 0 0 0 156 1 1
    NLRC4 GBP2 0 0 216 316 1 1
    NLRC4 RELA 0 0 211 211 1 1
    NLRC4 LY96 0 0 334 437 1 1
    NLRC4 NFKB1 0 0 202 226 1 1
    NLRC4 CSF2 0 0 324 323 1 1
    NLRC4 GAPDH 0 0 337 337 1 2
    NLRC4 ATG14 0 0 134 164 1 2
    NLRC4 SLC7A6OS 0 0 108 173 1 1
    NLRC4 TMEM74 0 0 181 181 1 2
    NLRC4 XIAP 0 0 293 461 1 1
    NLRC4 TLR4 0 0 653 703 1 1
    NLRC4 NOS2 0 0 164 169 1 1
    NLRC4 PANX1 0 0 503 504 1 1
    NLRC4 GABARAPL2 0 0 150 173 1 2
    NLRC4 GAPT 0 0 0 212 1 1
    NLRC4 IKBKB 0 0 294 294 1 1
    NLRC4 ALOX5AP 0 0 0 213 1 1
    NLRC4 OAS2 0 0 118 152 1 1
    NLRC4 CD14 0 0 0 259 1 1
    NLRC4 HSP90AB1 0 0 44 223 1 2
    NLRC4 CXCL10 0 0 254 281 1 1
    NLRC4 KCNJ11 0 0 699 699 1 1
    NLRC4 MALT1 0 0 243 242 1 1
    NLRC4 BIRC8 0 0 49 275 1 1
    NLRC4 HCAR2 0 0 134 210 1 1
    NLRC4 ARHGAP30 0 0 0 169 1 1
    NLRC4 CYLD 0 0 195 195 1 1
    NLRC4 BRINP1 0 0 49 221 1 1
    NLRC4 GSDMD 0 720 789 949 1 1
    NLRC4 CREB1 0 0 105 170 1 1
    NLRC4 HCST 0 0 0 154 1 1
    NLRC4 CCL5 0 0 286 312 1 1
    NLRC4 PLCG2 0 0 212 263 1 1
    NLRC4 BIRC5 0 0 74 294 1 2
    NLRC4 BIRC2 0 0 275 543 1 1
    NLRC4 IFNG 0 0 218 377 1 2
    NLRC4 IRF3 0 0 455 455 1 1
    NLRC4 LGALS9 0 0 57 155 1 1
    NLRC4 TNFSF13 0 0 0 151 1 1
    NLRC4 NLRP7 0 0 739 833 1 1
    NLRC4 ANXA5 0 0 158 157 1 1
    NLRC4 C5AR1 0 0 112 173 1 1
    NLRC4 PYCARD 500 800 840 989 1 1
    NLRC4 CFP 0 0 81 180 1 1
    NLRC4 MGAM 0 0 0 151 1 1
    NLRC4 CD1D 0 0 122 208 1 1
    NLRC4 CARD6 0 0 155 192 1 1
    NLRC4 GPR183 0 0 46 176 1 1
    NLRC4 CLEC12B 0 0 0 161 1 1
    NLRC4 CLEC4D 0 0 218 343 1 1
    NLRC4 TLR9 0 0 519 559 1 1
    NLRC4 GSDMA 0 0 503 506 1 1
    NLRC4 PTGS1 0 0 431 464 1 1
    NLRC4 CD40LG 0 0 171 210 1 1
    NLRC4 IRF8 0 0 216 308 1 1
    NLRC4 ENTPD1 0 0 75 206 1 1
    NLRC4 SRC 0 0 162 161 1 1
    NLRC4 DOCK2 0 0 91 168 1 1
    NLRC4 MARK4 0 0 122 212 1 1
    NLRC4 PIDD1 0 0 163 163 1 1
    NLRC4 SIN3B 0 0 112 174 1 1
    NLRC4 CDC42 0 0 201 201 1 1
    NLRC4 RAG1 0 0 134 183 1 1
    NLRC4 GIMAP8 0 0 124 265 1 1
    NLRC4 CD163 0 0 124 376 1 1
    NLRC4 GIMAP6 0 0 82 176 1 1
    NLRC4 IL36B 0 0 75 234 1 1
    NLRC4 TRPV2 0 0 134 185 1 1
    NLRC4 NLRP1 270 720 983 996 1 1
    NLRC4 BBOX1 0 0 193 193 1 1
    NLRC4 IL6 0 0 560 566 1 1
    NLRC4 TREML1 0 0 0 151 1 1
    NLRC4 SCAF11 0 0 234 234 1 1
    NLRC4 LYZ 0 0 71 172 1 1
    NLRC4 PIK3C3 0 0 169 179 1 2
    NLRC4 P2RY13 0 0 0 212 1 1
    NLRC4 MPO 0 0 261 305 1 1
    NLRC4 NLRC3 0 0 636 666 1 1
    NLRC4 ATG3 0 0 134 157 1 2
    NLRC4 XK 270 0 0 270 1 1
    NLRC4 PLEK 0 0 0 214 1 1
    NLRC4 LGALS3 0 0 166 165 1 1
    NLRC4 TLR3 0 0 517 527 1 1
    NLRC4 TNFRSF1A 0 0 323 323 1 1
    NLRC4 GZMB 0 0 113 188 1 1
    NLRC4 BIRC6 0 0 63 286 1 1
    NLRC4 DEFB1 0 0 157 156 1 1
    NLRC4 CD52 0 0 0 151 1 1
    NLRC4 RGS18 0 0 0 277 1 1
    NLRC4 STAT1 0 0 331 331 1 1
    NLRC4 LYST 0 0 206 250 1 1
    NLRC4 IL1B 0 0 803 840 1 1
    NLRC4 RAC2 0 0 134 185 1 1
    NLRC4 P2RX1 0 0 62 174 1 1
    NLRC4 HCLS1 0 0 0 157 1 1
    NLRC4 STXBP2 0 0 157 177 1 1
    NLRC4 NPL 0 0 0 173 1 1
    NLRC4 HIF1A 0 0 152 151 1 2
    NLRC4 PRKCB 0 0 57 175 1 2
    NLRC4 FOXP3 0 0 211 211 1 1
    NLRC4 CTSL 0 0 306 306 1 1
    NLRC4 HMOX1 0 0 134 166 1 2
    NLRC4 POP4 0 0 72 215 1 1
    NLRC4 HLA-DOB 0 0 69 150 1 1
    NLRC4 ENSG00000268500 0 0 90 340 1 1
    NLRC4 CXCL8 0 0 423 457 1 1
    NLRC4 ADAP2 0 0 0 180 1 1
    NLRC4 CLEC5A 0 0 175 348 1 1
    NLRC4 MARVELD1 0 0 81 223 1 1
    NLRC4 TBK1 0 0 324 338 1 2
    NLRC4 TICAM2 0 0 66 167 1 1
    NLRC4 RIPK3 0 0 377 448 1 1
    NLRC4 PRKCD 0 800 468 908 1 2
    NLRC4 FCGR3A 0 0 113 335 1 1
    NLRC4 TEP1 0 0 129 167 1 1
    NLRC4 MS4A4A 0 0 0 193 1 1
    NLRC4 IKBKE 0 0 142 173 1 1
    NLRC4 C1QB 0 0 90 195 1 1
    NLRC4 DPP8 0 0 184 214 1 1
    NLRC4 LACC1 0 0 150 174 1 1
    NLRC4 C3AR1 0 0 95 258 1 1
    NLRC4 ERBB2IP 0 0 234 257 1 1
    NLRC4 CXCR2 0 0 168 219 1 1
    NLRC4 PLA2G4A 0 0 96 353 1 1
    NLRC4 RAB7B 0 0 155 154 1 1
    NLRC4 HPRT1 0 0 170 169 1 1
    NLRC4 RNASEL 0 0 166 178 1 1
    NLRC4 APAF1 0 0 580 580 1 1
    NLRC4 NLRC5 0 0 742 764 1 1
    NLRC4 CARD18 0 0 322 340 1 1
    NLRC4 COLEC12 0 0 135 268 1 1
    NLRC4 APOBR 0 0 0 181 1 1
    NLRC4 LY86 0 0 0 212 1 1
    NLRC4 CYBA 0 0 163 193 1 1
    NLRC4 FGR 0 0 47 283 1 1
    NLRC4 CTLA4 0 0 193 193 1 1
    NLRC4 ARHGAP25 0 0 62 165 1 1
    NLRC4 MARCH1 0 0 52 192 1 1
    NLRC4 CD300C 0 0 155 339 1 1
    NLRC4 NT5C2 0 0 850 857 1 1
    NLRC4 TXN 0 0 261 261 1 1
    NLRC4 DEFA1 0 0 108 158 1 1
    NLRC4 S100A10 0 0 0 248 1 1
    NLRC4 STAT3 0 0 292 307 1 2
    NLRC4 PTPN22 0 0 125 168 1 1
    NLRC4 SFTPD 0 0 143 171 1 1
    NLRC4 IFT43 0 0 388 388 1 1
    NLRC4 CFTR 0 0 212 212 1 1
    NLRC4 IRF9 0 0 170 169 1 1
    NLRC4 LCN2 0 0 217 218 1 1
    NLRC4 TP53 0 900 193 915 1 2
    NLRC4 ADORA3 0 0 43 153 1 1
    NLRC4 FCGR1A 0 0 144 272 1 1
    NLRC4 DEFB103A 0 0 184 183 1 1
    NLRC4 PPP1CC 0 0 0 207 1 1
    NLRC4 NSMCE4A 0 0 96 152 1 1
    NLRC4 MYD88 0 0 635 653 1 1
    NLRC4 PSTPIP1 0 0 391 427 1 1
    NLRC4 CFLAR 0 0 232 277 1 1
    NLRC4 LAMP1 0 0 235 235 1 2
    NLRC4 LRRC25 0 0 0 165 1 1
    NLRC4 ESX1 0 0 321 345 1 1
    NLRC4 NLRP2 0 0 664 382 1 1
    NLRC4 FADD 270 0 390 536 1 2
    NLRC4 SARM1 0 0 170 169 1 1
    NLRC4 CD274 0 0 124 166 1 1
    NLRC4 CSF2RB 0 0 0 213 1 1
    NLRC4 CAMP 0 0 262 337 1 1
    NLRC4 TRAF1 0 0 124 166 1 1
    NLRC4 DOK3 0 0 0 213 1 1
    NLRC4 CARD9 0 0 482 530 1 1
    NLRC4 IRAK1 0 0 390 396 1 1
    NLRC4 PSTPIP2 0 0 126 152 1 1
    NLRC4 P2RX4 0 0 214 215 1 1
    NLRC4 CSF3 0 0 213 213 1 1
    NLRC4 CD200R1 0 0 97 165 1 1
    NLRC4 IRAK2 0 0 218 263 1 1
    NLRC4 NCF1 0 0 154 241 1 1
    NLRC4 VNN2 0 0 0 219 1 1
    NLRC4 CRADD 0 0 329 329 1 1
    NLRC4 ANXA2 0 0 71 169 1 1
    NLRC4 ZBP1 0 0 179 200 1 1
    NLRC4 LIPN 0 0 0 185 1 1
    NLRC4 PTAFR 0 0 90 168 1 1
    NLRC4 APBB1IP 0 0 0 151 1 1
    NLRC4 NLRP4 213 0 607 690 1 1
    NLRC4 SELPLG 0 0 0 175 1 1
    NLRC4 CD19 0 0 141 172 1 1
    NLRC4 MAP3K7 0 0 195 195 1 1
    NLRC4 HK3 0 0 0 333 1 1
    NLRC4 S100A9 0 0 64 232 1 1
    NLRC4 RELB 0 0 145 169 1 2
    NLRC4 MROH6 0 0 167 187 1 1
    NLRC4 RAB7A 0 0 150 186 1 2
    NLRC4 CLEC4A 0 0 94 354 1 1
    NLRC4 TFEC 0 0 0 231 1 1
    NLRC4 TYMP 0 0 0 183 1 1
    NLRC4 TXNIP 0 0 423 442 1 1
    NLRC4 IFI16 0 0 612 662 1 1
    NLRC4 BCL2A1 0 0 61 169 1 1
    NLRC4 IFNAR1 0 0 314 329 1 1
    NLRC4 IL1RL2 0 0 167 185 1 1
    NLRC4 FLII 0 0 117 172 1 1
    NLRC4 IL1R2 0 0 155 259 1 1
    NLRC4 IL5 0 0 204 204 1 1
    NLRC4 CMKLR1 0 0 74 169 1 1
    NLRC4 TNFAIP3 0 0 218 246 1 1
    NLRC4 MPEG1 0 0 54 202 1 1
    NLRC4 CASP10 0 0 159 199 1 1
    NLRC4 ATG4B 0 0 166 182 1 2
    NLRC4 IL17RC 0 0 125 151 1 1
    NLRC4 NFKB2 0 0 183 183 1 1
    NLRC4 UNC13D 0 0 145 166 1 1
    NLRC4 CSF1R 0 0 88 249 1 1
    NLRC4 DEFB4A 0 0 241 240 1 1
    NLRC4 IRF7 0 0 323 347 1 1
    NLRC4 MARCH7 0 0 205 205 1 1
    NLRC4 CLEC1B 0 0 0 157 1 1
    NLRC4 BTK 0 0 107 277 1 1
    NLRC4 SLAMF8 0 0 0 181 1 1
    NLRC4 NLRP10 0 0 602 602 1 1
    NLRC4 TLR1 0 0 465 626 1 1
    NLRC4 ARHGAP9 0 0 0 165 1 1
    NLRC4 MS4A14 0 0 0 277 1 1
    NLRC4 DHX58 0 0 370 400 1 1
    NLRC4 RBCK1 0 0 186 186 1 1
    NLRC4 GBP5 0 0 425 498 1 1
    NLRC4 RETN 0 0 54 208 1 1
    NLRC4 CD80 0 0 209 247 1 1
    NLRC4 NLRP12 0 0 740 740 1 1
    NLRC4 IL18 0 0 856 868 1 1
    NLRC4 IFNA1 0 0 326 325 1 1
    NLRC4 IRGM 0 0 307 307 1 2
    NLRC4 MYC 0 0 238 238 1 2
    NLRC4 ITGAE 0 0 246 260 1 1
    NLRC4 IL1RN 0 0 357 423 1 1
    NLRC4 CASP2 0 0 432 447 1 1
    NLRC4 SIRPD 0 0 0 214 1 1
    NLRC4 FCGR1B 0 0 0 198 1 1
    NLRC4 IL1R1 0 0 556 565 1 1
    NLRC4 NBR1 0 0 169 169 1 2
    NLRC4 TANK 0 0 143 229 1 1
    NLRC4 TNF 0 0 562 608 1 1
    NLRC4 TAGAP 0 0 0 213 1 1
    NLRC4 TREM1 0 0 150 304 1 1
    NLRC4 LILRA1 0 0 0 332 1 1
    NLRC4 PRB1 0 0 209 209 1 1
    NLRC4 TIRAP 0 0 380 380 1 1
    NLRC4 TAB2 0 0 233 232 1 1
    NLRC4 VPS11 0 0 75 173 1 2
    NLRC4 IL36G 0 0 52 198 1 1
    NLRC4 DFNB59 0 0 218 218 1 1
    NLRC4 DHX33 0 720 294 793 1 1
    NLRC4 CD300A 0 0 57 172 1 1
    NLRC4 FUT7 0 0 0 161 1 1
    NLRC4 MX1 0 0 140 158 1 1
    NLRC4 TAB1 0 0 213 213 1 1
    NLRC4 DDX3X 0 720 93 735 1 1
    NLRC4 RRS1 0 0 123 219 1 1
    NLRC4 MEFV 0 0 857 883 1 2
    NLRC4 NAIP 270 800 989 978 1 1
    NLRC4 MS4A6A 0 0 0 267 1 1
    NLRC4 IFI30 0 0 61 158 1 1
    NLRC4 CD300LF 0 0 57 291 1 1
    NLRC4 PLCB2 0 0 0 151 1 1
    NLRC4 CD209 0 0 203 203 1 1
    NLRC4 CLEC10A 0 0 0 157 1 1
    NLRC4 CECR1 0 0 126 163 1 1
    NLRC4 DFNA5 0 0 414 414 1 1
    NLRC4 CTSK 0 0 306 319 1 1
    NLRC4 LYN 0 0 113 165 1 1
    NLRC4 CYCS 0 0 263 263 1 1
    NLRC4 IFNB1 0 0 507 514 1 1
    NLRC4 PPP1CA 0 0 0 207 1 1
    NLRC4 MAPK9 0 0 427 427 1 2
    NLRC4 IRF5 0 0 141 208 1 1
    NLRC4 DUOX2 0 0 155 154 1 1
    NLRC4 HMGB1 0 0 417 424 1 2
    NLRC4 TLR7 0 0 469 508 1 1
    NLRC4 CASP9 0 0 360 377 1 1
    NLRC4 PSMC5 486 0 667 822 1 1
    NLRC4 IL18BP 0 0 420 434 1 1
    NLRC4 PYHIN1 0 0 324 393 1 1
    NLRC4 P2RY2 0 0 166 190 1 1
    NLRC4 ITGAM 0 0 340 519 1 1
    NLRC4 TRAF6 0 0 391 390 1 2
    NLRC4 RGS1 0 0 82 153 1 1
    NLRC4 IL10RB 0 0 139 167 1 1
    NLRC4 NLRP5 0 0 406 406 1 1
    NLRC4 CTSB 0 0 503 503 1 2
    NLRC4 IL17A 0 0 450 450 1 1
    NLRC4 SPI1 0 0 460 616 1 1
    NLRC4 MS4A7 0 0 0 264 1 1
    NLRC4 PRTN3 0 0 245 262 1 1
    NLRC4 CST7 0 0 0 151 1 1
    NLRC4 SASH3 0 0 0 152 1 1
    NLRC4 CX3CR1 0 0 203 250 1 1
    NLRC4 C1QA 0 0 0 152 1 1
    NLRC4 PYDC1 0 0 468 468 1 1
    NLRC4 IRF1 0 0 261 277 1 1
    NLRC4 DEFB103B 0 0 184 183 1 1
    NLRC4 TLR8 0 0 450 618 1 1
    NLRC4 CXCL9 0 0 141 179 1 1
    NLRC4 ATG5 0 0 325 325 1 2
    NLRC4 CLEC12A 0 0 66 316 1 1
    NLRC4 LAPTM5 0 0 0 169 1 1
    NLRC4 CALCOCO2 0 0 213 213 1 2
    NLRC4 NLRP14 0 0 370 465 1 1
    NLRC4 MVK 0 0 299 299 1 1
    NLRC4 CCR2 0 0 234 322 1 2
    NLRC4 NFKBIB 0 0 113 150 1 1
    NLRC4 EMC2 0 0 43 207 1 1
    NLRC4 AQP9 0 0 0 271 1 1
    NLRC4 IFIH1 0 0 504 525 1 1
    NLRC4 FAM72A 0 0 0 190 1 1
    NLRC4 VPS18 0 0 82 179 1 1
    NLRC4 DIABLO 0 0 181 181 1 1
    NLRC4 SLC15A3 0 0 74 187 1 1
    NLRC4 WDFY4 0 0 0 229 1 1
    NLRC4 TUFM 0 0 149 188 1 1
    NLRC4 CDKL4 0 0 122 195 1 1
    NLRC4 BATF3 0 0 81 197 1 1
    NLRC4 MYO1F 0 0 0 169 1 1
    NLRC4 IL1F10 0 0 140 273 1 1
    NLRC4 MAP1LC3B 0 0 157 164 1 2
    NLRC4 CD244 0 0 0 154 1 1
    NLRC4 PTGER4 0 0 117 164 1 1
    NLRC4 NCF2 0 0 97 370 1 1
    NLRC4 MBTPS2 0 0 357 357 1 1
    NLRC4 CMA1 0 0 181 181 1 1
    NLRC4 TIFAB 0 0 0 155 1 1
    NLRC4 IL2RG 0 0 53 187 1 1
    NLRC4 PRF1 0 0 269 304 1 1
    NLRC4 CEACAM4 0 0 0 299 1 1
    NLRC4 CCR1 0 0 74 241 1 1
    NLRC4 GBP3 0 0 134 212 1 1
    NLRC4 P2RX7 0 0 466 548 1 1
    NLRC4 CXCR5 0 0 63 657 1 1
    NLRC4 MAPK8 0 0 203 203 1 2
    NLRC4 NSMAF 0 0 66 274 1 1
    NLRC4 ARG1 0 0 134 176 1 1
    NLRC4 PILRA 0 0 0 194 1 1
    NLRC4 CASR 0 0 181 181 1 1
    NLRC4 C1QC 0 0 81 174 1 1
    NLRC4 CCR7 0 0 112 165 1 1
    NLRC4 IKBKG 0 0 341 354 1 1
    NLRC4 ULK1 0 0 174 173 1 2
    NLRC4 TBX21 0 0 146 231 1 1
    NLRC4 CD300LB 0 0 0 332 1 1
    NLRC4 PKN1 0 0 219 282 1 1
    NLRC4 LILRB2 0 0 0 531 1 1
    NLRC4 SLA 0 0 0 262 1 1
    NLRC4 ELANE 0 0 246 279 1 1
    NLRC4 LILRB3 0 0 0 213 1 1
    NLRC4 PRKCA 0 0 74 234 1 1
    NLRC4 FCGR3B 0 0 113 282 1 1
    NLRC4 CCL3 0 0 230 276 1 1
    NLRC4 CTSG 0 0 233 260 1 1
    NLRC4 DDX58 0 0 608 616 1 1
    NLRC4 AIM2 0 720 988 997 1 1
    NLRC4 EMILIN2 0 0 0 151 1 1
    NLRC4 PYDC2 0 0 279 279 1 1
    NLRC4 AGER 0 0 213 251 1 1
    NLRC4 IL18RAP 0 0 233 368 1 1
    NLRC4 MB21D1 0 0 390 390 1 1
    NLRC4 NCF4 0 0 90 225 1 1
    NLRC4 BCL2L13 0 0 207 207 1 1
    NLRC4 AMICA1 0 0 0 155 1 1
    NLRC4 MARCO 0 0 72 192 1 1
    NLRC4 PARVG 0 0 51 163 1 1
    NLRC4 RNF31 0 0 212 212 1 1
    NLRC4 CXCL2 0 0 284 284 1 1
    NLRC4 IRAK4 0 0 341 355 1 1
    NLRC4 GLMN 0 800 270 847 1 1
    NLRC4 IL10 0 0 427 444 1 1
    NLRC4 CCL20 0 0 185 185 1 1
    NLRC4 PIK3AP1 0 0 54 183 1 1
    NLRC4 TRADD 0 0 190 214 1 1
    NLRC4 GIMAP7 0 0 61 157 1 1
    NLRC4 SIGLEC9 0 0 72 290 1 1
    NLRC4 IAPP 0 0 249 248 1 1
    NLRC4 TRAT1 0 0 294 312 1 1
    NLRC4 MAVS 0 0 507 507 1 1
    NLRC4 SRGN 0 0 0 151 1 1
    NLRC4 ATG7 0 0 258 258 1 2
    NLRC4 IL1A 0 0 561 561 1 1
    NLRC4 GBP1 0 0 107 198 1 1
    NLRC4 CCL4 0 0 181 261 1 1
    NLRC4 CD68 0 0 160 229 1 1
    NLRC4 CASP8 675 0 854 952 1 2
    NLRC4 ALB 0 0 218 247 1 1
    NLRC4 FFAR4 0 0 142 160 1 1
    NLRC4 CCL2 0 0 325 325 1 2
    NLRC4 LRRFIP1 0 0 177 177 1 1
    NLRC4 SDHA 0 0 193 193 1 1
    NLRC4 NME8 0 0 0 151 1 1
    NLRC4 CASP5 0 720 662 943 1 1
    NLRC4 SLC7A7 0 0 0 265 1 1
    NLRC4 CYTIP 0 0 0 152 1 1
    NLRC4 CEACAM3 0 0 0 207 1 1
    NLRC4 CARD17 0 0 322 762 1 1
    NLRC4 FCER1G 0 0 57 204 1 1
    NLRC4 STX11 0 0 150 302 1 1
    NLRC4 TYROBP 0 0 101 319 1 1
    NLRC4 GSDMC 0 0 154 159 1 1
    NLRC4 NEK7 0 0 560 560 1 1
    NLRC4 MCEMP1 0 0 0 298 1 1
    NLRC4 CASP7 0 0 427 446 1 1
    NLRC4 LRR1 0 0 147 278 1 1
    NLRC4 TNFAIP8L2 0 0 58 226 1 1
    NLRC4 NLRP6 0 540 955 979 1 1
    NLRC4 FPR1 0 0 326 420 1 1
    NLRC4 AOAH 0 0 0 272 1 1
    NLRC4 PLBD1 0 0 59 167 1 1
    NLRC4 IL4 0 0 294 294 1 1
    NLRC4 FCGR2A 0 0 136 236 1 1
    NLRC4 LGALS8 0 0 130 156 1 1
    NLRC4 DOCK8 0 0 90 176 1 1
    NLRC4 WDR1 0 0 218 218 1 1
    NLRC4 CLEC4E 0 0 324 416 1 1
    NLRC4 FOLR3 0 0 0 151 1 1
    NLRC4 CFL1 0 0 142 160 1 1
    NLRC4 MAPK14 0 0 124 194 1 1
    NLRC4 LRRFIP2 0 0 252 252 1 1
    NLRC4 NFKBIA 0 0 369 369 1 1
    NLRC4 SLC46A2 0 0 0 152 1 1
    NLRC4 SYK 0 0 408 477 1 1
    NLRC4 BIRC3 0 0 183 496 1 1
    NLRC4 IL17F 0 0 193 193 1 1
    NLRC4 ATG12 0 0 226 225 1 2
    NLRC4 PRKCQ 0 0 67 177 1 2
    NLRC4 ACTB 0 0 364 371 1 1
    NLRC4 INS 0 0 181 181 1 1
    NLRC4 RNASE2 0 0 0 181 1 1
    NLRC4 IL13 0 0 261 261 1 1
    NLRC4 CTSS 0 0 0 212 1 1
    NLRC4 NLRX1 0 0 632 641 1 1
    NLRC4 GPR34 0 0 0 161 1 1
    NLRC4 VIL1 0 0 134 169 1 1
    NLRC4 CD40 0 0 218 235 1 1
    NLRC4 GBP7 0 0 142 201 1 1
    NLRC4 THEMIS2 0 0 0 185 1 1
    NLRC4 RPS2 0 0 126 158 1 1
    NLRC4 SELL 0 0 75 184 1 1
    NLRC4 TNFSF13B 0 0 126 216 1 1
    NLRC4 FPR2 0 0 87 195 1 1
    NLRC4 ALOX5 0 0 90 272 1 1
    NLRC4 CXCL5 0 0 113 156 1 1
    NLRC4 MAPK3 0 0 262 262 1 2
    NLRC4 MMP9 0 0 166 250 1 1
    NLRC4 FPR3 0 0 0 151 1 1
    NLRC4 GPR65 0 0 0 212 1 1
    NLRC4 FCGR2B 0 0 130 246 1 1
    NLRC4 BNIP3 0 0 160 159 1 2
    NLRC4 SQSTM1 0 0 218 218 1 2
    NLRC4 CYBB 0 0 293 424 1 1
    NLRC4 GIMAP4 0 0 50 181 1 1
    NLRC4 NLRP3 270 720 989 998 1 2
    NLRC4 HSP90AA1 0 0 620 620 1 2
    NLRC4 REL 0 0 174 173 1 1
    NLRC4 CD53 0 0 42 175 1 1
    NLRC4 CARD16 0 0 258 757 1 1
    NLRC4 PLA2G7 0 0 66 187 1 1
    NLRC4 IL33 0 0 458 457 1 1
    NLRC4 ATG4D 0 0 143 164 1 2
    NLRC4 CXCL1 0 0 330 343 1 1
    NLRC4 IL21 0 0 0 299 1 1
    NLRC4 NKG7 0 0 0 152 1 1
    NLRC4 PTGS2 0 0 309 334 1 1
    NLRC4 CASP3 0 0 378 394 1 2
    NLRC4 PGLYRP1 0 0 240 295 1 1
    NLRC4 CRP 0 0 184 183 1 1
    NLRC4 RANGAP1 0 0 0 183 1 1
    NLRC4 IL1RL1 0 0 181 181 1 1
    NLRC4 MSR1 0 0 69 178 1 1
    NLRC4 ATG16L1 0 0 460 459 1 2
    NLRC4 MLKL 0 0 373 403 1 1
    NLRC4 BCL10 270 0 325 486 1 1
    NLRC4 CXCR1 0 0 113 245 1 1
    NLRC4 HCK 0 0 104 305 1 1
    NLRC4 NLRP9 0 720 508 786 1 1
    NLRC4 FYB 0 0 0 151 1 1
    NLRC4 NOD2 486 0 886 748 1 1
    NLRC4 PTPRC 0 0 246 349 1 1
    NLRC4 CIITA 0 0 561 621 1 1
    NLRC4 GPR84 0 0 47 161 1 1
    NLRC4 CSF1 0 0 261 274 1 1
    NLRC4 IL22 0 0 181 186 1 1
    NLRC4 RIPK1 0 0 358 358 1 1
    NLRC4 VPS16 0 0 89 185 1 1
    NLRC4 GABARAPL1 0 0 151 150 1 2
    NLRC4 ICAM1 0 0 150 171 1 1
    NLRC4 RALB 0 0 96 187 1 1
    NLRC4 UNC93B1 0 0 181 229 1 1
    NLRC4 SLC25A38 0 0 0 177 1 1
    NLRC4 ITGAX 0 0 325 413 1 1
    NLRC4 SLC11A1 0 0 241 317 1 1
    NLRC4 RAB24 0 0 155 154 1 2
    NLRC4 MRC1 0 0 112 173 1 1
    NLRC4 RHOA 0 0 204 204 1 1
    NLRC4 CASP4 0 540 417 827 1 2
    NLRC4 PARP1 0 0 234 234 1 2
    NLRC4 FGL2 0 0 0 290 1 1
    NLRC4 CD1C 0 0 70 157 1 1
    NLRC4 HSPA8 0 0 705 705 1 2
    NLRC4 CHUK 0 0 323 323 1 1
    NLRC4 NLRP11 0 0 391 413 1 1
    NLRC4 TLR5 0 0 807 839 1 1
    NLRC4 S100A12 0 0 150 354 1 1
    NLRC4 IL36A 0 0 45 194 1 1
    NLRC4 SAMHD1 0 0 134 189 1 1
    NLRC4 IL1RAP 0 0 246 245 1 1
    NLRC4 SIGLEC7 0 0 0 214 1 1
    NLRC4 CD8A 0 0 403 433 1 1
    NLRC4 OSCAR 0 0 0 212 1 1
    NLRC4 VIPR1 0 0 162 161 1 1
    NLRC4 EIF2AK2 270 0 143 361 1 2
    NLRC4 GPBAR1 0 0 105 230 1 1
    NLRC4 TBXAS1 0 0 0 157 1 1
    NLRC4 IFNGR1 0 0 150 188 1 1
    NLRC4 ITGB2 0 0 48 305 1 1
    NLRC4 IL22RA2 0 0 170 169 1 1
    NLRC4 RIPK2 0 0 643 643 1 1
    NLRC4 KCNK6 0 0 155 199 1 1
    NLRC4 PKN2 0 0 211 274 1 1
    NLRC4 MNDA 0 0 284 556 1 1
    NLRC4 IGSF6 0 0 52 327 1 1
    NLRC4 CLEC9A 0 0 150 181 1 1
    NLRC4 CLEC6A 0 0 325 393 1 1
    NLRC4 IL17RA 0 0 206 260 1 1
    NLRC4 CCRL2 0 0 122 213 1 1
    NLRC4 ACAP1 0 0 130 264 1 1
    NLRC4 TICAM1 0 0 267 289 1 1
    NLRC4 S100A8 0 0 134 289 1 1
    NLRC4 FASLG 0 0 176 206 1 1
    NLRC4 NLRP8 0 0 340 407 1 1
    NLRC4 SIGIRR 0 0 210 210 1 1
    NLRC4 IRAK3 0 0 245 322 1 1
    NLRC4 RNASE6 0 0 0 193 1 1
    NLRC4 FCER1A 0 0 0 151 1 1
    NLRC4 IL37 0 0 178 261 1 1
    NLRC4 BIRC7 0 0 0 395 1 1
    NLRC4 CCR5 0 0 108 321 1 1
    NLRC4 CSTA 0 0 0 153 1 1
    NLRC4 IL36RN 0 0 193 263 1 1
    NLRC4 S1PR4 0 0 0 181 1 1
    NLRC4 SIGLEC1 0 0 64 163 1 1
    NLRC4 C1orf162 0 0 0 325 1 1
    NLRC4 NLRP13 0 0 626 626 1 1
    NLRC4 SERPINA1 0 0 73 163 1 2
    NLRC4 ENSG00000173366 0 0 518 534 1 1
    NLRC4 FCN1 0 0 44 189 1 1
    NLRC4 WAS 0 0 95 189 1 1
    NLRC4 CD86 0 0 219 374 1 1
    NLRC4 SERPINB2 0 0 88 169 1 1
    NLRC4 IL18R1 0 0 253 295 1 1
    NLRC4 DPP9 0 0 148 187 1 1
    NLRC4 GZMA 0 0 73 161 1 1
    NLRC4 IL10RA 0 0 184 316 1 1
    NLRC4 CARD11 0 0 95 164 1 1
    NLRC4 TMEM173 0 0 284 317 1 1
    NLRC4 NOD1 270 0 813 561 1 1
    NLRC4 JUN 0 0 224 224 1 1
    NLRC4 SHARPIN 0 0 180 179 1 1
    NLRC4 DHX15 0 0 122 262 1 1
    NLRC4 CASP1 753 800 989 999 1 2
    NLRC4 NRL 0 0 64 165 1 1
    NLRC4 VSIG4 0 0 0 179 1 1
    NLRC4 EVI2B 0 0 0 208 1 1
    NLRC4 TLR6 0 0 419 480 1 1
    NLRC4 IL2 0 0 215 215 1 1
    NLRC4 BECN1 0 0 895 944 1 2
    NLRC4 TRAF3 0 0 286 286 1 2
    NLRC4 TOLLIP 0 0 154 153 1 1
    NLRC4 LRRK2 0 0 510 585 1 2
    NLRC4 TLR2 0 0 609 717 1 1
    NLRC4 TNFSF10 0 0 152 184 1 2
    NLRC4 GBP4 0 0 122 215 1 1
    NLRC4 AIF1 0 0 139 218 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005524 Molecular Function ATP binding enables IDA
    GO:0089720 Molecular Function caspase binding enables IPI
    GO:0061133 Molecular Function endopeptidase activator activity enables IGI
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0000287 Molecular Function magnesium ion binding enables TAS
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IDA
    GO:0002218 Biological Process activation of innate immune response involved_in ISS
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0042742 Biological Process defense response to bacterium involved_in IBA
    GO:0042742 Biological Process defense response to bacterium involved_in IDA
    GO:0016045 Biological Process detection of bacterium involved_in IBA
    GO:0016045 Biological Process detection of bacterium involved_in IDA
    GO:0046456 Biological Process icosanoid biosynthetic process involved_in NAS
    GO:0006954 Biological Process inflammatory response involved_in ISS
    GO:0045087 Biological Process innate immune response involved_in IEA
    GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in NAS
    GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
    GO:0050729 Biological Process positive regulation of inflammatory response involved_in NAS
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IGI
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in NAS
    GO:0010954 Biological Process positive regulation of protein processing involved_in IGI
    GO:0051260 Biological Process protein homooligomerization involved_in ISS
    GO:0070269 Biological Process pyroptotic inflammatory response involved_in ISS
    GO:0070269 Biological Process pyroptotic inflammatory response involved_in NAS
    GO:0072557 Cellular Component IPAF inflammasome complex part_of ISS
    GO:0061702 Cellular Component canonical inflammasome complex part_of NAS
    GO:0005737 Cellular Component cytoplasm located_in NAS
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in ISS
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in IDA
    Pathways
    Name DB ID
    Innate Immune System Reactome R-HSA-168249
    Immune System Reactome R-HSA-168256
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
    Generic Transcription Pathway Reactome R-HSA-212436
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
    Inflammasomes Reactome R-HSA-622312
    TP53 Regulates Transcription of Caspase Activators and Caspases Reactome R-HSA-6803207
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    The IPAF inflammasome Reactome R-HSA-844623
    Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001302504 1 mRNA transcript variant 4 NC_000002 Reference
    NM_021209 4 mRNA transcript variant 1 NC_000002 Reference
    NM_001199139 1 mRNA transcript variant 3 NC_000002 Reference
    NM_001199138 2 mRNA transcript variant 2 NC_000002 Reference
    XM_047445356 1 mRNA transcript variant X1 NC_000002 Reference