HAdb 2.0 is available now!

GAS5

growth arrest specific 5
General Information
Name growth arrest specific 5
Alias
  • growth arrest specific 5 (non-protein coding)
  • growth arrest specific transcript 5
  • small nucleolar RNA host gene (non-protein coding) 2
Gene_family Long non-coding RNAs with non-systematic symbols|Small nucleolar RNA non-coding host genes
organism Homo sapiens
entrez_id 60674
location 1q25.1
transcript_count 50
exon_count 13
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
GAS5 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
GAS5 BioGRID TP53 GeneID BioGRID Affinity Capture-RNA
GAS5 BioGRID EP300 GeneID BioGRID Affinity Capture-RNA
GAS5 BioGRID STAT3 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
GAS5 BioGRID YTHDF3 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
GAS5 BioGRID YAP1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
GAS5 BioGRID PTGS2 GeneID BioGRID Protein-RNA
GAS5 BioGRID APEX1 GeneID BioGRID Affinity Capture-RNA
GAS5 BioGRID RUNX3 GeneID BioGRID Affinity Capture-RNA
GAS5 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
StringDB
A B experiments database textmining combined score hadb nhadb
Ontologies
ID Category Term Effect Evidence PubMed
GO:0035198 Molecular Function miRNA binding enables IDA
GO:0140869 Molecular Function miRNA inhibitor activity via base-pairing enables IDA
GO:0071404 Biological Process cellular response to low-density lipoprotein particle stimulus involved_in IMP
GO:0034599 Biological Process cellular response to oxidative stress involved_in IMP
GO:0006954 Biological Process inflammatory response involved_in IMP
GO:0000512 Biological Process lncRNA-mediated post-transcriptional gene silencing involved_in IDA
GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IDA
Pathways
Name DB ID
Burn wound healing (WP5055) WikiPathways WP5055_r122621
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_186289 1 ncRNA transcript variant 49 NC_000001 Reference
NR_152521 2 ncRNA transcript variant 2 NC_000001 Reference
NR_186290 1 ncRNA transcript variant 50 NC_000001 Reference
NR_186288 1 ncRNA transcript variant 48 NC_000001 Reference
NR_186255 1 ncRNA transcript variant 16 NC_000001 Reference
NR_186270 1 ncRNA transcript variant 31 NC_000001 Reference
NR_186266 1 ncRNA transcript variant 27 NC_000001 Reference
NR_186260 1 ncRNA transcript variant 21 NC_000001 Reference
NR_186285 1 ncRNA transcript variant 45 NC_000001 Reference
NR_186263 1 ncRNA transcript variant 24 NC_000001 Reference
NR_186271 1 ncRNA transcript variant 32 NC_000001 Reference
NR_186265 1 ncRNA transcript variant 26 NC_000001 Reference
NR_186258 1 ncRNA transcript variant 19 NC_000001 Reference
NR_186275 1 ncRNA transcript variant 36 NC_000001 Reference
NR_152527 2 ncRNA transcript variant 8 NC_000001 Reference
NR_186262 1 ncRNA transcript variant 23 NC_000001 Reference
NR_186272 1 ncRNA transcript variant 33 NC_000001 Reference
NR_186261 1 ncRNA transcript variant 22 NC_000001 Reference
NR_186277 1 ncRNA transcript variant 37 NC_000001 Reference
NR_152529 2 ncRNA transcript variant 10 NC_000001 Reference
NR_186286 1 ncRNA transcript variant 46 NC_000001 Reference
NR_186278 1 ncRNA transcript variant 38 NC_000001 Reference
NR_186279 1 ncRNA transcript variant 39 NC_000001 Reference
NR_152534 2 ncRNA transcript variant 15 NC_000001 Reference
NR_152522 2 ncRNA transcript variant 3 NC_000001 Reference
NR_186284 1 ncRNA transcript variant 44 NC_000001 Reference
NR_186273 1 ncRNA transcript variant 34 NC_000001 Reference
NR_152523 2 ncRNA transcript variant 4 NC_000001 Reference
NR_152530 2 ncRNA transcript variant 11 NC_000001 Reference
NR_152526 2 ncRNA transcript variant 7 NC_000001 Reference
NR_152528 2 ncRNA transcript variant 9 NC_000001 Reference
NR_186267 1 ncRNA transcript variant 28 NC_000001 Reference
NR_186256 1 ncRNA transcript variant 17 NC_000001 Reference
NR_186264 1 ncRNA transcript variant 25 NC_000001 Reference
NR_186281 1 ncRNA transcript variant 41 NC_000001 Reference
NR_186274 1 ncRNA transcript variant 35 NC_000001 Reference
NR_186268 1 ncRNA transcript variant 29 NC_000001 Reference
NR_152524 2 ncRNA transcript variant 5 NC_000001 Reference
NR_186257 1 ncRNA transcript variant 18 NC_000001 Reference
NR_152533 2 ncRNA transcript variant 14 NC_000001 Reference
NR_002578 4 ncRNA transcript variant 1 NC_000001 Reference
NR_152525 2 ncRNA transcript variant 6 NC_000001 Reference
NR_186283 1 ncRNA transcript variant 43 NC_000001 Reference
NR_152531 2 ncRNA transcript variant 12 NC_000001 Reference
NR_186259 1 ncRNA transcript variant 20 NC_000001 Reference
NR_186287 1 ncRNA transcript variant 47 NC_000001 Reference
NR_186282 1 ncRNA transcript variant 42 NC_000001 Reference
NR_186269 1 ncRNA transcript variant 30 NC_000001 Reference
NR_186280 1 ncRNA transcript variant 40 NC_000001 Reference
NR_152532 2 ncRNA transcript variant 13 NC_000001 Reference