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BCR

BCR activator of RhoGEF and GTPase
General Information
Name BCR activator of RhoGEF and GTPase
Alias
  • breakpoint cluster region protein
  • BCR, RhoGEF and GTPase activating protein
  • BCR/FGFR1 chimera protein
  • FGFR1/BCR chimera protein
  • breakpoint cluster region
  • renal carcinoma antigen NY-REN-26
Gene_family C2 domain containing|My-T-BRC complex|Dbl family Rho GEFs|Pleckstrin homology domain containing
organism Homo sapiens
entrez_id 613
location 22q11.23
transcript_count 2
exon_count 23
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
    Stringdb Breakpoint cluster region protein; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity; C2 domain containing
    nextProt Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
BCR BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
BCR BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
BCR BioGRID GTF3C1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID EPS15 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CHD2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CHD1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID ATRX GeneID BioGRID Affinity Capture-MS
BCR BioGRID GPATCH2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NRDE2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID RNF111 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DDX41 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GABARAPL1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GABARAP GeneID BioGRID Affinity Capture-MS
BCR BioGRID KAT7 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NOLC1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PCGF5 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CCNL2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID WDR82 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NKAP GeneID BioGRID Affinity Capture-MS
BCR BioGRID HIRIP3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID YWHAH GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
BCR BioGRID YWHAE GeneID BioGRID Affinity Capture-MS
BCR BioGRID YWHAB GeneID BioGRID Affinity Capture-MS
BCR BioGRID RBBP4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PNN GeneID BioGRID Affinity Capture-MS
BCR BioGRID INPPL1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS
BCR BioGRID YWHAG GeneID BioGRID Affinity Capture-MS
BCR BioGRID GSK3B GeneID BioGRID Proximity Label-MS
BCR BioGRID GSK3A GeneID BioGRID Proximity Label-MS
BCR BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS
BCR BioGRID STAU1 GeneID BioGRID Proximity Label-MS
BCR BioGRID PHF21A GeneID BioGRID Proximity Label-MS
BCR BioGRID RCOR1 GeneID BioGRID Proximity Label-MS
BCR BioGRID KDM1A GeneID BioGRID Proximity Label-MS
BCR BioGRID HDAC1 GeneID BioGRID Proximity Label-MS
BCR BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DDR2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CCNF GeneID BioGRID Proximity Label-MS
BCR BioGRID DDR1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
BCR BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
BCR BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
BCR BioGRID PTPN1 GeneID BioGRID Affinity Capture-Western; FRET
BCR BioGRID INF2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID KCMF1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NOP53 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PYCR2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SIN3A GeneID BioGRID Affinity Capture-MS
BCR BioGRID EDC4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GTPBP4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NUP188 GeneID BioGRID Affinity Capture-MS
BCR BioGRID UBR4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID RRP12 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CNOT1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DDX20 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CPSF6 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GCN1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID USP39 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PNMA2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CTCF GeneID BioGRID Affinity Capture-MS
BCR BioGRID MRPL28 GeneID BioGRID Affinity Capture-MS
BCR BioGRID TUBGCP3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PSMD14 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SEC16A GeneID BioGRID Affinity Capture-MS
BCR BioGRID G3BP2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GTF3C3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID UBE2M GeneID BioGRID Affinity Capture-MS
BCR BioGRID DYNLL1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID API5 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NUP214 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SH2D5 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MRPL10 GeneID BioGRID Affinity Capture-MS
BCR BioGRID LTV1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID TRMT1L GeneID BioGRID Affinity Capture-MS
BCR BioGRID GEMIN6 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DDX54 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MRPL41 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GYS1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID FRK GeneID BioGRID Affinity Capture-MS
BCR BioGRID ECH1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DPYSL2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DYNC1H1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CSNK2A2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CSNK2A1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID UTRN GeneID BioGRID Affinity Capture-MS
BCR BioGRID TFAM GeneID BioGRID Affinity Capture-MS
BCR BioGRID RRM2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID RANGAP1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PSMD8 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MAP1B GeneID BioGRID Affinity Capture-MS
BCR BioGRID SMURF2 GeneID BioGRID Affinity Capture-Western
BCR BioGRID CSNK2B GeneID BioGRID Affinity Capture-MS
BCR BioGRID RAC1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
BCR BioGRID RHOC GeneID BioGRID Affinity Capture-MS
BCR BioGRID RHOB GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
BCR BioGRID RHOA GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
BCR BioGRID RSPH9 GeneID BioGRID Affinity Capture-MS
BCR BioGRID AGO4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID COMMD1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NUDCD2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CCDC183 GeneID BioGRID Affinity Capture-MS
BCR BioGRID JPH4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SLA2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SYNC GeneID BioGRID Affinity Capture-MS
BCR BioGRID VPS33A GeneID BioGRID Proximity Label-MS
BCR BioGRID NAGK GeneID BioGRID Affinity Capture-MS
BCR BioGRID BACE2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PSD4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MAP4K1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GRAP2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID NAA10 GeneID BioGRID Affinity Capture-MS
BCR BioGRID EZR GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
BCR BioGRID TULP3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SURF6 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SEC13 GeneID BioGRID Affinity Capture-MS
BCR BioGRID RDX GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
BCR BioGRID PDZK1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GRB2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
BCR BioGRID ERCC3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
BCR BioGRID AP2M1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID ATG10 GeneID BioGRID Phenotypic Suppression
BCR BioGRID ATG3 GeneID BioGRID Phenotypic Suppression
BCR BioGRID ATG7 GeneID BioGRID Phenotypic Suppression
BCR BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
BCR BioGRID MAPRE3 GeneID BioGRID Proximity Label-MS
BCR BioGRID DCTN2 GeneID BioGRID Proximity Label-MS
BCR BioGRID ACTR1A GeneID BioGRID Proximity Label-MS
BCR BioGRID CEP135 GeneID BioGRID Proximity Label-MS
BCR BioGRID VASP GeneID BioGRID Proximity Label-MS
BCR BioGRID USP1 GeneID BioGRID Affinity Capture-Western
BCR BioGRID RAB2A GeneID BioGRID Proximity Label-MS
BCR BioGRID PFN1 GeneID BioGRID Proximity Label-MS
BCR BioGRID AFDN GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Proximity Label-MS; Reconstituted Complex; Two-hybrid
BCR BioGRID CTNNA1 GeneID BioGRID Proximity Label-MS
BCR BioGRID CLTA GeneID BioGRID Proximity Label-MS
BCR BioGRID ANK3 GeneID BioGRID Proximity Label-MS
BCR BioGRID AP2B1 GeneID BioGRID Proximity Label-MS
BCR BioGRID MYC GeneID BioGRID Affinity Capture-MS
BCR BioGRID SAMD4B GeneID BioGRID Proximity Label-MS
BCR BioGRID CECR2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID BRPF3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SMG6 GeneID BioGRID Proximity Label-MS
BCR BioGRID TRIM66 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SP110 GeneID BioGRID Affinity Capture-MS
BCR BioGRID HSCB GeneID BioGRID Affinity Capture-MS
BCR BioGRID ARHGEF39 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
BCR BioGRID AP2A1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PLK1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PTPN3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID HOOK3 GeneID BioGRID Proximity Label-MS
BCR BioGRID SCAI GeneID BioGRID Affinity Capture-MS
BCR BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
BCR BioGRID PIK3R1 GeneID BioGRID Affinity Capture-Western; Far Western
BCR BioGRID RECQL4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID DPF2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
BCR BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
BCR BioGRID RAD51 GeneID BioGRID Reconstituted Complex
BCR BioGRID ABL1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
BCR BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
BCR BioGRID USP15 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SPAG9 GeneID BioGRID Affinity Capture-MS
BCR BioGRID WEE1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MCM6 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MCM4 GeneID BioGRID Affinity Capture-MS
BCR BioGRID MCM2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CSNK1A1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PTPN6 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
BCR BioGRID TP53 GeneID BioGRID Co-localization; Two-hybrid
BCR BioGRID PIK3CG GeneID BioGRID Affinity Capture-Western; Co-localization
BCR BioGRID KIT GeneID BioGRID Affinity Capture-Western; Co-localization
BCR BioGRID Scai GeneID BioGRID Affinity Capture-MS
BCR BioGRID CEP128 GeneID BioGRID Proximity Label-MS
BCR BioGRID NINL GeneID BioGRID Proximity Label-MS
BCR BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CRKL GeneID BioGRID Affinity Capture-Western; Far Western; Two-hybrid
BCR BioGRID Numb GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BCR BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID UBC GeneID BioGRID Affinity Capture-Western; Two-hybrid
BCR BioGRID HSPD1 GeneID BioGRID Affinity Capture-Western
BCR BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Western
BCR BioGRID HSPA4 GeneID BioGRID Affinity Capture-Western
BCR BioGRID DOK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
BCR BioGRID PTGES3 GeneID BioGRID Affinity Capture-Western
BCR BioGRID ERBIN GeneID BioGRID Affinity Capture-Western; Protein-peptide
BCR BioGRID Tamalin GeneID BioGRID Two-hybrid
BCR BioGRID CFTR GeneID BioGRID Affinity Capture-MS
BCR BioGRID PXN GeneID BioGRID Affinity Capture-Western
BCR BioGRID CBL GeneID BioGRID Affinity Capture-MS; Biochemical Activity; Reconstituted Complex
BCR BioGRID UBASH3B GeneID BioGRID Affinity Capture-MS
BCR BioGRID LRRK1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID SHC1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID PIK3R2 GeneID BioGRID Affinity Capture-MS
BCR BioGRID GRK5 GeneID BioGRID Affinity Capture-MS
BCR BioGRID CRK GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
BCR BioGRID LNX1 GeneID BioGRID Two-hybrid
BCR BioGRID GABRR1 GeneID BioGRID Affinity Capture-MS
BCR BioGRID HIF1A GeneID BioGRID Affinity Capture-Western
BCR BioGRID STUB1 GeneID BioGRID Biochemical Activity
BCR BioGRID HSPA8 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
BCR BioGRID INPP5D GeneID BioGRID Affinity Capture-Western
BCR BioGRID VPS28 GeneID BioGRID Affinity Capture-Western
BCR BioGRID TSG101 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCR BioGRID WDR48 GeneID BioGRID Affinity Capture-MS
BCR Protein IGSF21 GeneID HPRD
BCR Protein YWHAG GeneID HPRD
BCR Protein YWHAE GeneID HPRD
BCR Protein MAP4K5 GeneID HPRD
BCR Protein APBA3 GeneID HPRD
BCR Protein UNC119 GeneID HPRD
BCR Protein CRKL GeneID HPRD
BCR Protein GRB10 GeneID HPRD
BCR Protein SFN GeneID HPRD
BCR Protein YWHAB GeneID HPRD
BCR Protein YWHAZ GeneID HPRD
BCR Protein DLG1 GeneID HPRD
BCR Protein SHC1 GeneID HPRD
BCR Protein BLK GeneID HPRD
BCR Protein TP53 GeneID HPRD
BCR Protein SRC GeneID HPRD
BCR Protein FES GeneID HPRD
BCR Protein ABL1 GeneID HPRD
BCR Protein PTPN1 GeneID HPRD
BCR Protein PTPN6 GeneID HPRD
BCR Protein PTPN11 GeneID HPRD
BCR Protein PLCG1 GeneID HPRD
BCR Protein VAV1 GeneID HPRD
BCR Protein CRK GeneID HPRD
BCR Protein ABL2 GeneID HPRD
BCR Protein AFDN GeneID HPRD
BCR Protein BCR GeneID HPRD
BCR Protein JAK2 GeneID HPRD
BCR Protein IRS1 GeneID HPRD
BCR Protein YWHAQ GeneID HPRD
BCR Protein HNF1A GeneID HPRD
BCR Protein HCK GeneID HPRD
BCR Protein RASA1 GeneID HPRD
BCR Protein ERCC3 GeneID HPRD
BCR Protein YWHAH GeneID HPRD
BCR Protein GRB2 GeneID HPRD
BCR BioGRID SOS1 GeneID BioGRID Affinity Capture-Western
BCR BioGRID IL3 GeneID BioGRID Affinity Capture-Western
BCR BioGRID FES GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
BCR BioGRID CDC42 GeneID BioGRID Reconstituted Complex
BCR BioGRID IGSF21 GeneID BioGRID Two-hybrid
BCR BioGRID UNC119 GeneID BioGRID Two-hybrid
BCR BioGRID GAB2 GeneID BioGRID Affinity Capture-Western
BCR BioGRID RB1 GeneID BioGRID Affinity Capture-Western
BCR BioGRID HOXA9 GeneID BioGRID Phenotypic Enhancement
BCR BioGRID HCK GeneID BioGRID Affinity Capture-Western
BCR Protein GRB2 GeneID BIND Grb2 interacts with Bcr-Abl.
BCR Protein GRB2 GeneID BIND Tyrosine phosphorylated Bcr-Abl interacts with Grb2.
BCR Protein BCR GeneID BIND p210 Bcr-Abl phosphorylates p160 Bcr.
BCR Protein PTPN11 GeneID BIND Phosphorylated p210bcr-abl interacts with phosphorylated Syp. This interaction was modeled on a demonstrated interaction between human p210bcr-abl and mouse Syp.
BCR Protein ABL1 GeneID BIND BCR interacts with c-Abl. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human c-Abl.
BCR Protein ABL2 GeneID BIND BCR interacts with ARG. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human ARG.
BCR Protein SRC GeneID BIND BCR interacts with Src. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and Src from Rous Sarcoma virus.
BCR Protein PLCG1 GeneID BIND BCR interacts with PLCgamma1. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and bovine PLCgamma1.
BCR Protein RASA1 GeneID BIND BCR interacts with GAP. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human GAP.
StringDB
A B experiments database textmining combined score hadb nhadb
BCR RNF150 0 0 90 406 1 1
BCR YWHAH 310 0 46 332 1 1
BCR PTGES3 270 0 0 270 1 1
BCR RAB42 0 0 0 166 1 1
BCR WTIP 0 0 0 170 1 1
BCR HCK 678 0 296 768 1 1
BCR RAB2B 0 0 0 166 1 1
BCR SNURF 0 0 431 431 1 1
BCR PIK3CD 0 0 241 249 1 1
BCR FGF9 0 500 0 521 1 1
BCR PGM3 0 0 134 164 1 1
BCR RIN1 0 0 303 318 1 1
BCR SESTD1 0 0 96 276 1 1
BCR ENSG00000271449 0 0 184 183 1 1
BCR EPHB2 0 0 119 159 1 2
BCR GUSB 0 0 194 194 1 1
BCR SFN 213 0 0 219 1 2
BCR CDKN2A 0 0 260 260 1 2
BCR BLK 213 0 96 272 1 1
BCR EIF3A 0 0 325 325 1 1
BCR GSK3B 0 0 82 188 1 2
BCR XRCC5 0 0 134 166 1 1
BCR CCNG1 0 0 0 157 1 1
BCR FGF8 0 500 0 499 1 1
BCR CD5 0 0 155 154 1 1
BCR ARHGEF38 0 0 0 178 1 1
BCR DIRAS3 0 0 0 169 1 2
BCR NR2C2 0 0 0 189 1 1
BCR TIMELESS 0 0 66 231 1 1
BCR PLEKHG4 0 0 112 211 1 1
BCR LIMS1 0 0 0 170 1 1
BCR LIMS3 0 0 0 170 1 1
BCR FAM168A 0 0 444 444 1 1
BCR LIMS3L 0 0 0 170 1 1
BCR LMO7 0 0 0 232 1 1
BCR MLLT3 0 0 503 537 1 1
BCR SLC45A3 0 0 153 158 1 1
BCR CASP3 0 0 233 239 1 2
BCR RAB4B 0 0 0 166 1 1
BCR AICDA 0 0 181 181 1 1
BCR ARHGAP29 0 0 0 215 1 1
BCR KIAA1524 0 0 451 458 1 1
BCR HNRNPL 270 0 0 270 1 1
BCR LNX1 192 0 46 289 1 1
BCR BRCA2 0 0 150 240 1 1
BCR ZMYND8 0 0 0 189 1 1
BCR RHOBTB3 0 0 0 273 1 1
BCR CD72 0 900 0 900 1 1
BCR MYH11 0 0 379 379 1 1
BCR RASL10B 0 0 0 169 1 1
BCR NAAA 0 0 181 181 1 1
BCR PAK4 0 0 45 245 1 1
BCR SNX16 0 0 92 178 1 1
BCR REM2 0 0 0 169 1 1
BCR FGF23 0 500 0 499 1 1
BCR MAPK11 0 0 48 174 1 1
BCR PIK3CB 0 0 183 192 1 1
BCR ERLIN2 0 500 0 499 1 1
BCR MET 0 0 180 196 1 2
BCR MAOB 0 0 296 296 1 1
BCR NAP1L4 0 0 396 396 1 1
BCR SHC4 0 800 0 800 1 1
BCR ABCB1 0 0 293 293 1 2
BCR WEE1 130 0 62 207 1 1
BCR RASL11A 0 0 0 169 1 1
BCR ABCC1 0 0 113 172 1 1
BCR ARF6 0 0 0 166 1 1
BCR ARL4C 0 0 0 166 1 1
BCR ASB2 0 0 164 163 1 1
BCR KRAS 0 0 234 372 1 2
BCR PGD 0 0 413 412 1 1
BCR RAB39B 0 0 0 166 1 1
BCR RND2 0 0 96 314 1 1
BCR NAA30 0 0 90 240 1 1
BCR NRAS 0 0 166 277 1 1
BCR FGF20 0 500 0 521 1 1
BCR TOP2B 0 0 211 215 1 1
BCR ENSG00000268861 0 0 0 297 1 1
BCR STAT5A 0 900 450 944 1 1
BCR LMO2 0 0 328 328 1 1
BCR AJUBA 0 0 0 170 1 1
BCR LMO1 0 0 433 433 1 1
BCR HM13 0 0 0 162 1 1
BCR RAB11B 0 0 0 166 1 1
BCR CRKL 675 900 504 984 1 1
BCR PTPN11 213 0 200 388 1 1
BCR ZNF470 0 0 246 245 1 1
BCR YWHAZ 213 0 73 257 1 1
BCR GAS7 0 0 161 268 1 1
BCR RHOD 0 0 190 386 1 1
BCR PRKAR1A 0 0 125 179 1 2
BCR TSG101 270 0 454 585 1 2
BCR ADI1 0 0 0 212 1 1
BCR USP18 0 0 49 213 1 1
BCR ATP2B1 161 0 0 161 1 1
BCR TET2 0 0 140 158 1 2
BCR VAV1 213 0 204 352 1 1
BCR KLHL23 0 0 134 286 1 1
BCR ARL13B 0 0 0 166 1 1
BCR DFFB 0 0 150 203 1 1
BCR WDR11 0 0 142 161 1 1
BCR UBC 270 0 42 283 1 2
BCR PAG1 0 900 0 900 1 1
BCR SGIP1 0 0 0 161 1 1
BCR SMG6 273 0 0 305 1 1
BCR RAD52 0 0 134 171 1 1
BCR RASL10A 0 0 90 211 1 1
BCR RAD51B 0 0 295 295 1 1
BCR RARA 0 0 618 618 1 2
BCR RALA 0 0 89 211 1 1
BCR NUMA1 0 0 148 166 1 1
BCR FN1 0 0 161 161 1 2
BCR RASL11B 0 0 0 169 1 1
BCR GEM 0 0 0 169 1 1
BCR BCOR 0 0 134 152 1 1
BCR SPI1 0 0 141 161 1 1
BCR MCL1 0 0 181 181 1 2
BCR NRD1 0 0 0 153 1 1
BCR TMEM178B 0 0 164 164 1 1
BCR SMARCA4 0 0 284 296 1 1
BCR GMIP 0 0 0 213 1 1
BCR ARHGDIG 0 0 0 248 1 1
BCR RAC1 270 900 193 951 1 2
BCR LIMCH1 0 0 0 232 1 1
BCR ESR1 0 0 170 169 1 2
BCR LYN 0 900 414 941 1 1
BCR APBA3 297 0 74 321 1 1
BCR MLLT1 0 0 369 409 1 1
BCR YIPF1 0 0 49 218 1 1
BCR RAB15 0 0 0 170 1 1
BCR MYO7A 0 0 0 151 1 1
BCR TRIP6 0 0 0 170 1 1
BCR NCEH1 0 0 0 248 1 1
BCR MCF2 0 0 261 261 1 1
BCR MPL 0 0 160 159 1 1
BCR PTPN1 270 0 62 315 1 1
BCR MAPK7 0 0 63 166 1 1
BCR VEGFA 0 0 260 270 1 2
BCR PTEN 0 900 281 926 1 2
BCR MLLT6 0 0 330 330 1 1
BCR SCEL 0 0 0 232 1 1
BCR WT1 0 0 167 167 1 1
BCR FHL1 0 0 0 232 1 1
BCR MAP3K3 0 0 0 322 1 1
BCR KIT 676 0 561 852 1 2
BCR RHOT2 0 0 0 166 1 1
BCR NUP98 0 0 180 269 1 1
BCR SYK 0 900 161 916 1 2
BCR SH3GL1 0 0 294 299 1 1
BCR MAPK14 0 0 82 183 1 2
BCR CSF3R 0 0 141 167 1 1
BCR RSPH9 271 0 0 271 1 1
BCR CD79A 0 900 161 915 1 1
BCR SARNP 0 0 358 358 1 1
BCR SLC4A4 0 0 330 330 1 1
BCR ATM 0 0 193 193 1 2
BCR SUGCT 0 0 283 356 1 1
BCR SHC1 389 900 453 963 1 1
BCR PRICKLE2 0 0 0 232 1 1
BCR EZR 129 0 96 205 1 1
BCR RET 0 0 307 307 1 1
BCR DIRAS2 0 0 0 169 1 1
BCR THSD7B 0 0 0 190 1 1
BCR DHX8 0 0 0 215 1 1
BCR RECQL4 270 0 0 270 1 1
BCR SKAP2 0 0 223 228 1 1
BCR IKZF1 0 0 322 321 1 1
BCR SP110 154 0 0 164 1 1
BCR DLG4 0 0 66 205 1 2
BCR FMN1 0 0 46 269 1 1
BCR MRAS 0 0 0 169 1 1
BCR CT45A2 0 0 194 194 1 1
BCR FLT3 0 0 469 469 1 2
BCR ABCC10 0 0 175 175 1 1
BCR NPM1 0 0 391 390 1 1
BCR CDK1 0 0 181 241 1 2
BCR DOT1L 0 0 145 179 1 1
BCR EIF4E 0 0 107 159 1 2
BCR PAK6 0 0 0 242 1 1
BCR MUC1 0 0 453 453 1 1
BCR ETV6 0 0 415 422 1 1
BCR PRKDC 0 0 170 188 1 2
BCR RPS6KB1 0 900 90 905 1 2
BCR REM1 0 0 0 280 1 1
BCR YWHAQ 213 0 0 219 1 1
BCR GOLGA5 0 0 95 331 1 1
BCR CBL 737 600 181 907 1 1
BCR IRS1 213 0 70 236 1 2
BCR RERGL 0 0 0 169 1 1
BCR RRAD 0 0 0 169 1 1
BCR ACTR10 0 0 81 249 1 1
BCR LOX 0 0 94 150 1 2
BCR NTRK1 63 0 213 246 1 1
BCR ASIC1 0 0 329 329 1 2
BCR SCAI 270 0 55 280 1 1
BCR EPOR 0 0 147 169 1 1
BCR BAALC 0 0 95 157 1 1
BCR CD19 0 900 284 925 1 1
BCR GGTLC1 0 0 143 321 1 1
BCR FGF5 0 500 0 499 1 1
BCR MYO18A 0 500 74 527 1 1
BCR ACTN1 0 0 268 268 1 1
BCR PSIP1 0 0 130 170 1 1
BCR BLNK 0 900 113 910 1 1
BCR NCF1 0 0 0 359 1 1
BCR ABCG2 0 0 261 375 1 1
BCR ARL16 0 0 0 166 1 1
BCR TACC3 0 0 193 236 1 1
BCR COPB1 161 0 0 180 1 1
BCR ZNF569 0 0 155 154 1 1
BCR CCND1 0 0 242 241 1 2
BCR MEIS1 0 0 142 174 1 1
BCR ZCCHC7 0 0 134 226 1 1
BCR RRAS2 0 0 0 169 1 1
BCR ELL 0 0 371 399 1 1
BCR RAB14 0 0 0 166 1 1
BCR SH3BGR 0 0 270 299 1 1
BCR CD38 0 0 245 244 1 2
BCR RHEB 0 0 0 169 1 2
BCR CD46 0 0 0 242 1 2
BCR CCDC183 204 0 0 204 1 1
BCR RASA1 213 900 104 926 1 1
BCR FCHO1 0 0 0 161 1 1
BCR MECOM 0 0 208 208 1 1
BCR RUNX1 0 0 217 217 1 2
BCR INF2 0 0 0 265 1 1
BCR GFI1 0 0 49 151 1 1
BCR IDE 0 0 0 157 1 1
BCR DNAJC27 0 0 0 166 1 1
BCR DEK 0 0 202 202 1 1
BCR DAAM2 0 0 0 265 1 1
BCR PIK3R2 158 0 243 353 1 1
BCR HTR2C 0 0 439 439 1 1
BCR LMCD1 0 0 0 232 1 1
BCR TJP2 297 0 0 297 1 1
BCR ERCC3 869 0 0 871 1 1
BCR ABI2 0 0 155 154 1 1
BCR BAG4 0 500 0 499 1 1
BCR TMEM147 0 0 164 163 1 1
BCR RABL2B 0 0 0 166 1 1
BCR ITCH 0 0 0 179 1 1
BCR MKRN3 0 0 498 497 1 1
BCR RND3 0 0 108 324 1 1
BCR SOS1 486 900 112 952 1 1
BCR TMPRSS2 0 0 185 202 1 1
BCR MAP3K14 0 0 0 177 1 1
BCR CD2AP 0 0 0 203 1 1
BCR RHOF 0 0 95 314 1 1
BCR TFRC 0 0 157 161 1 1
BCR FHL3 0 0 0 232 1 1
BCR PLEKHA4 270 0 0 270 1 1
BCR KMT2A 0 0 507 517 1 1
BCR FGF2 0 500 91 526 1 2
BCR SLAMF9 0 0 0 444 1 1
BCR UBASH3B 158 0 180 280 1 1
BCR RHEBL1 0 0 0 169 1 1
BCR DCAF5 0 0 539 549 1 1
BCR ARHGAP9 0 0 0 230 1 1
BCR FHIT 0 0 184 183 1 1
BCR BTK 0 900 219 920 1 1
BCR FCHO2 0 0 0 161 1 1
BCR RAB39A 0 0 0 166 1 1
BCR MAPK1 0 0 134 231 1 2
BCR CSF1R 0 0 321 330 1 1
BCR THOC2 0 0 0 189 1 1
BCR UBQLN1 0 0 0 203 1 1
BCR BCL6 0 900 218 918 1 1
BCR BMP8B 0 0 387 386 1 1
BCR CCNG2 0 0 46 161 1 1
BCR RHOC 0 0 95 314 1 1
BCR DRD4 0 0 388 388 1 1
BCR FOXO4 0 0 150 175 1 1
BCR GRK5 270 0 0 285 1 1
BCR GABRR1 270 0 0 270 1 1
BCR TSN 0 0 148 234 1 1
BCR ARHGEF12 0 0 296 313 1 1
BCR MAP3K1 0 0 0 207 1 1
BCR CHRM2 0 0 322 321 1 1
BCR ERBB2 0 0 341 355 1 2
BCR CD34 0 0 470 473 1 2
BCR ECE1 0 0 246 245 1 1
BCR DDR1 0 0 203 203 1 1
BCR GIGYF1 0 0 0 172 1 1
BCR PHF14 0 0 107 464 1 1
BCR AP2M1 469 0 0 469 1 1
BCR CSF2 0 0 171 171 1 1
BCR GGT1 0 0 134 361 1 1
BCR PRICKLE3 0 0 0 232 1 1
BCR KLHDC9 0 0 0 159 1 1
BCR ARL5A 0 0 0 166 1 1
BCR PPP1R9B 0 0 57 233 1 1
BCR GIPC1 297 0 0 297 1 1
BCR AKT1 0 0 414 438 1 2
BCR RASD2 0 0 0 169 1 1
BCR UBE3A 0 0 397 402 1 1
BCR MAGEL2 0 0 351 351 1 1
BCR ARL15 0 0 0 166 1 1
BCR INPP5D 270 900 95 930 1 1
BCR RAB40C 0 0 0 170 1 1
BCR CD4 0 0 211 313 1 2
BCR PATE2 0 0 128 217 1 1
BCR TNKS2 312 0 0 327 1 1
BCR AHI1 0 0 410 410 1 1
BCR BRPF3 154 0 0 153 1 1
BCR FGFR1 0 500 304 637 1 1
BCR DLG1 213 0 0 251 1 1
BCR PPP2R4 0 0 181 181 1 1
BCR THOC6 0 0 55 212 1 1
BCR SHC2 0 800 0 800 1 1
BCR ARF4 0 0 0 166 1 1
BCR LRRK1 270 0 66 311 1 1
BCR CD82 0 0 183 239 1 1
BCR SEC13 196 0 0 196 1 1
BCR RHOH 0 0 103 320 1 1
BCR NRG1 0 0 183 183 1 2
BCR PTPN6 495 900 83 951 1 1
BCR ANPEP 0 0 392 392 1 1
BCR USP1 0 0 48 212 1 1
BCR JAK1 0 0 208 223 1 2
BCR KDR 0 0 163 163 1 2
BCR HTR1D 0 0 357 357 1 1
BCR DDX39B 0 0 150 281 1 1
BCR RAB11A 0 0 44 169 1 2
BCR RAC2 0 0 135 344 1 1
BCR ARHGAP15 0 0 0 243 1 1
BCR STAT5B 0 900 458 944 1 1
BCR TIAM1 0 0 270 230 1 1
BCR CDKN1B 0 0 125 157 1 2
BCR NUP214 0 0 210 210 1 1
BCR PRKCD 0 0 100 169 1 2
BCR CD2 0 0 283 282 1 1
BCR TLX1NB 0 0 504 504 1 1
BCR RB1 270 0 108 325 1 2
BCR CEP70 0 0 0 188 1 1
BCR FMNL1 0 0 0 265 1 1
BCR YWHAB 301 0 0 317 1 1
BCR GFM1 0 0 566 566 1 1
BCR CUX2 0 0 413 425 1 1
BCR FOXO3 0 0 170 174 1 2
BCR CCNI2 0 0 0 157 1 1
BCR CDC42 270 0 325 628 1 2
BCR GPN2 0 0 0 166 1 1
BCR GRAP 270 0 0 316 1 1
BCR LRBA 0 0 150 159 1 1
BCR SRC 213 0 509 613 1 2
BCR RAB25 0 0 0 166 1 2
BCR CCNO 0 0 0 157 1 1
BCR ARHGAP27 0 0 0 229 1 1
BCR TCL1A 0 0 354 354 1 1
BCR TASP1 0 0 210 280 1 1
BCR TXNDC9 0 0 438 438 1 1
BCR FLT1 0 0 155 154 1 1
BCR GMPS 0 0 388 388 1 1
BCR MAP3K19 0 0 0 177 1 1
BCR EWSR1 0 0 193 193 1 1
BCR PTPRM 0 0 67 203 1 1
BCR COMT 0 0 327 327 1 1
BCR RALB 0 0 0 169 1 2
BCR CCNB2 0 0 0 157 1 1
BCR PBX1 0 0 294 294 1 1
BCR GIGYF2 0 0 101 228 1 1
BCR MAP4K5 213 0 0 221 1 1
BCR PTPRC 0 900 183 920 1 1
BCR RASL12 0 0 0 169 1 1
BCR ABCA13 0 0 306 306 1 1
BCR RHOG 0 0 120 333 1 1
BCR WDR48 131 0 0 150 1 1
BCR ENSG00000271810 0 0 0 273 1 1
BCR FGF4 0 500 0 499 1 1
BCR KLHDC10 0 0 0 159 1 1
BCR LIMS2 0 0 0 170 1 1
BCR CXCL12 0 0 163 177 1 2
BCR RHOQ 0 0 108 324 1 1
BCR HSPA8 270 0 77 303 1 2
BCR TMEM185A 0 0 219 219 1 1
BCR AR 0 0 146 181 1 2
BCR RHOA 270 900 194 951 1 2
BCR ABTB1 0 0 86 153 1 1
BCR ERAS 0 0 0 169 1 1
BCR VPS28 270 0 0 270 1 1
BCR FCGR2B 0 900 52 901 1 1
BCR ROS1 0 0 108 152 1 1
BCR RND1 0 0 103 320 1 1
BCR MAPK3 0 0 194 284 1 2
BCR EXOC6B 0 0 0 152 1 1
BCR PAX5 0 0 229 228 1 1
BCR SUB1 0 0 306 306 1 1
BCR YIPF2 0 0 81 387 1 1
BCR ARL6 0 0 0 166 1 1
BCR KY 0 0 0 166 1 1
BCR STUB1 270 0 74 325 1 2
BCR TES 0 0 0 232 1 1
BCR ARHGDIA 0 0 51 256 1 1
BCR FGF1 0 500 56 507 1 1
BCR ACTB 0 0 182 239 1 2
BCR ZNF185 0 0 0 232 1 1
BCR ENSG00000137843 0 0 0 242 1 1
BCR SH2D5 270 0 457 639 1 1
BCR PSEN1 0 0 462 462 1 2
BCR FXYD1 0 0 55 478 1 1
BCR CEBPA 0 0 210 210 1 1
BCR RHOV 0 0 95 314 1 1
BCR WRN 0 0 134 167 1 1
BCR RGS12 297 0 0 297 1 1
BCR ZMYM2 0 500 251 609 1 1
BCR MYO9A 0 0 0 228 1 1
BCR KLHDC1 0 0 0 159 1 1
BCR SPAG9 131 0 0 150 1 1
BCR IL3 270 0 288 458 1 1
BCR HSP90AA1 675 0 283 757 1 2
BCR HEATR5B 0 0 0 160 1 1
BCR LASP1 0 0 360 360 1 1
BCR RHOT1 0 0 0 166 1 1
BCR PLCG1 213 900 92 924 1 1
BCR JUN 0 0 194 194 1 2
BCR GP1BA 0 0 89 185 1 1
BCR ARL4A 0 0 0 166 1 1
BCR RABEPK 0 0 0 159 1 1
BCR DAPP1 0 900 96 905 1 1
BCR GGTLC2 0 0 43 242 1 1
BCR SERPINB2 0 0 303 303 1 1
BCR BCL2L11 0 0 202 202 1 2
BCR SLC16A4 0 0 49 155 1 1
BCR CALB1 0 0 67 211 1 1
BCR PIK3CG 676 0 136 711 1 1
BCR JAK3 0 0 166 182 1 1
BCR ARL17B 0 0 0 166 1 1
BCR DNTT 0 0 244 243 1 1
BCR PRAM1 0 0 293 293 1 1
BCR SRRD 0 0 0 210 1 1
BCR ARID5B 0 0 123 165 1 1
BCR GM2A 0 0 163 163 1 1
BCR PVR 0 0 0 173 1 1
BCR TCF7 270 0 0 270 1 1
BCR NCKIPSD 0 0 124 227 1 1
BCR ETV1 0 0 134 161 1 1
BCR CRK 616 600 155 863 1 1
BCR FGFR1OP2 0 500 211 588 1 1
BCR RASD1 0 0 45 172 1 1
BCR TNFRSF8 0 0 113 208 1 1
BCR SEPT5 0 0 293 355 1 1
BCR CPSF6 0 500 90 576 1 1
BCR RAP2C 0 0 0 169 1 1
BCR FER 0 0 143 159 1 1
BCR SAE1 0 0 0 208 1 1
BCR CD8A 0 0 180 179 1 1
BCR NCOA4 0 0 167 167 1 2
BCR SHH 0 0 113 164 1 2
BCR CSNK1A1 130 0 48 158 1 1
BCR RABL2A 0 0 0 166 1 1
BCR FGF6 0 500 0 499 1 1
BCR NCK2 0 0 113 150 1 1
BCR FYN 0 0 261 289 1 1
BCR MYRF 0 0 392 392 1 1
BCR ABI1 0 0 219 219 1 1
BCR TPH2 0 0 357 357 1 1
BCR ARL10 0 0 0 166 1 1
BCR PVRL2 0 0 0 424 1 1
BCR GRB2 880 900 916 998 1 1
BCR LCK 0 0 266 280 1 1
BCR YWHAE 213 0 0 231 1 1
BCR CSK 0 900 134 911 1 1
BCR TEX13A 0 0 0 250 1 1
BCR CCDC6 0 0 148 286 1 1
BCR SNX29 0 0 94 169 1 1
BCR ABL2 213 0 294 456 1 1
BCR TNS1 0 0 159 184 1 1
BCR ARHGDIB 0 0 0 248 1 1
BCR PAK3 0 0 0 242 1 1
BCR PXN 270 0 134 399 1 1
BCR HIST2H3PS2 0 0 193 217 1 1
BCR RAB36 0 0 181 190 1 1
BCR AKAP13 0 0 91 185 1 1
BCR FBLIM1 0 0 0 170 1 1
BCR CD79B 0 900 0 908 1 1
BCR ARL4D 0 0 0 166 1 1
BCR BRAF 0 0 248 262 1 2
BCR ZNF33B 0 0 171 171 1 1
BCR PCM1 0 0 206 206 1 1
BCR PAK2 0 0 52 251 1 1
BCR IGHV4-38-2 0 0 402 402 1 1
BCR GGT5 0 0 67 210 1 1
BCR ARL9 0 0 0 166 1 1
BCR ZNF79 0 0 0 189 1 1
BCR MLLT11 0 0 126 163 1 1
BCR EGF 0 0 167 193 1 2
BCR FIP1L1 0 0 401 400 1 1
BCR GNAZ 0 0 157 156 1 1
BCR CRABP1 0 0 74 170 1 1
BCR HNF1A 213 0 0 213 1 1
BCR ARL11 0 0 0 166 1 1
BCR TIAM2 0 0 122 154 1 1
BCR FNBP1 0 0 297 322 1 1
BCR ARL5C 0 0 0 166 1 1
BCR MAPK9 0 0 141 151 1 2
BCR RAC3 0 0 120 352 1 2
BCR SLC22A1 0 0 287 286 1 1
BCR CHEK2 0 0 108 151 1 1
BCR CTXN1 0 0 143 184 1 1
BCR EXOC6 0 0 0 152 1 1
BCR HSPA4 270 0 112 324 1 1
BCR POM121 0 0 183 183 1 1
BCR SEPT9 0 0 57 177 1 1
BCR PCBP2 0 0 387 410 1 1
BCR GPHN 0 0 296 296 1 1
BCR ATL3 0 0 74 167 1 1
BCR CLTC 161 0 73 188 1 1
BCR PIK3R1 486 900 292 952 1 1
BCR PTPRK 0 0 107 208 1 1
BCR SNRPN 0 0 605 612 1 1
BCR RAP2A 0 0 0 169 1 1
BCR CRABP2 0 0 75 237 1 1
BCR ENSG00000255863 0 0 0 166 1 1
BCR CNTRL 0 500 57 508 1 1
BCR MME 0 0 284 284 1 1
BCR IGLL5 0 0 212 225 1 1
BCR LRRFIP1 0 500 60 522 1 1
BCR SERTAD3 0 0 272 272 1 1
BCR ALB 0 0 181 202 1 2
BCR DOK1 270 900 0 925 1 1
BCR LAGE3 0 0 234 234 1 1
BCR TNK2 0 0 132 189 1 1
BCR GOLGA4 0 0 504 504 1 1
BCR ARL17A 0 0 0 166 1 1
BCR MLLT4 486 0 468 722 1 1
BCR PDGFRB 0 0 404 404 1 2
BCR MLLT10 0 0 340 340 1 1
BCR RAP1B 0 0 0 169 1 1
BCR ENSG00000272822 0 0 0 166 1 1
BCR CSNK2A2 455 0 124 514 1 1
BCR RERG 0 0 0 169 1 1
BCR PDGFRA 0 0 362 362 1 1
BCR SCG2 0 0 309 309 1 1
BCR NCF4 0 0 0 359 1 1
BCR RAP2B 0 0 0 169 1 1
BCR FGF17 0 500 0 499 1 1
BCR CDH1 0 0 163 163 1 2
BCR CD33 0 0 380 380 1 1
BCR IDH1 0 0 146 177 1 1
BCR YWHAG 301 0 68 326 1 1
BCR CDK6 0 0 123 187 1 2
BCR SGK494 0 0 134 211 1 1
BCR RHOB 0 0 113 327 1 1
BCR ATP10A 0 0 387 386 1 1
BCR CUX1 0 500 108 545 1 1
BCR ALK 0 0 392 417 1 2
BCR CYP3A4 0 0 172 177 1 1
BCR FECH 0 0 306 306 1 1
BCR FAM149A 0 0 49 157 1 1
BCR CCNB3 0 0 0 157 1 1
BCR DEGS1 0 0 0 189 1 1
BCR DAAM1 0 0 0 265 1 1
BCR AFF4 0 0 98 160 1 1
BCR XRCC4 0 0 125 155 1 1
BCR LGALS4 0 0 119 161 1 1
BCR FAM109A 0 0 415 414 1 1
BCR ZYX 0 0 0 170 1 1
BCR RAB4A 0 0 0 166 1 1
BCR PSTPIP1 0 0 0 161 1 1
BCR CDK4 0 0 147 209 1 2
BCR EGFR 0 0 413 419 1 2
BCR FES 678 0 269 759 1 1
BCR TP53 381 0 390 606 1 2
BCR MDM2 0 0 232 253 1 2
BCR TUSC5 0 0 0 188 1 1
BCR GART 0 0 53 260 1 1
BCR TRIM24 0 500 74 523 1 1
BCR CFTR 221 0 122 286 1 2
BCR DDX54 0 0 123 198 1 1
BCR RAB2A 0 0 0 166 1 1
BCR EPS15 0 0 170 183 1 1
BCR FGFR1OP 0 500 154 586 1 1
BCR LPP 0 0 0 170 1 1
BCR MAP3K7 0 0 0 223 1 2
BCR PAM 0 0 62 573 1 1
BCR KLHDC2 0 0 0 159 1 1
BCR ARF5 0 0 0 166 1 1
BCR RAB10 0 0 44 151 1 1
BCR CSF3 0 0 204 204 1 1
BCR PSTPIP2 0 0 0 161 1 1
BCR RAF1 0 0 220 239 1 2
BCR TLX1 0 0 246 245 1 1
BCR ENSG00000124593 0 0 0 232 1 1
BCR MAML2 0 0 327 327 1 1
BCR BRD4 0 0 132 189 1 2
BCR FGR 0 0 218 233 1 1
BCR LIMD1 0 0 0 173 1 1
BCR SH3BP5 0 900 0 900 1 1
BCR HOOK3 117 0 89 213 1 1
BCR DIRAS1 0 0 0 169 1 1
BCR PAK1 0 0 0 242 1 2
BCR JAK2 213 900 464 955 1 2
BCR CHN1 0 0 438 298 1 1
BCR HSCB 270 0 0 270 1 1
BCR AFF1 0 0 517 517 1 1
BCR TPMT 0 0 120 152 1 1
BCR SHC3 0 800 0 807 1 1
BCR CCNI 0 0 0 157 1 1
BCR HMHA1 0 0 74 225 1 1
BCR STAT3 0 650 276 737 1 2
BCR DEGS2 0 0 0 189 1 1
BCR FMN2 0 0 0 265 1 1
BCR RPN1 0 0 165 165 1 1
BCR PTPRT 0 0 182 332 1 1
BCR TRIM23 0 0 0 166 1 1
BCR TBCD 0 0 249 248 1 1
BCR TXNDC8 0 0 55 160 1 1
BCR HOXA9 209 0 291 415 1 1
BCR TSPEAR 0 0 398 398 1 1
BCR IGF1R 0 0 136 172 1 2
BCR RIT1 0 0 0 169 1 1
BCR CSH2 0 0 253 252 1 1
BCR TPH1 0 0 384 384 1 1
BCR MYC 103 0 426 463 1 2
BCR ARL8B 0 0 0 166 1 1
BCR LMO3 0 0 389 388 1 1
BCR HTR1B 0 0 306 306 1 1
BCR DIRC2 0 0 53 275 1 1
BCR DDX47 0 0 134 165 1 1
BCR SLC6A4 0 0 329 329 1 1
BCR CBWD1 0 0 134 188 1 1
BCR IFNA1 0 0 213 213 1 1
BCR POM121L1P 0 0 376 376 1 1
BCR TOP1 0 0 193 214 1 1
BCR GAB2 270 600 324 785 1 1
BCR ARHGAP19 0 0 0 276 1 1
BCR PIK3CA 0 900 182 915 1 2
BCR TMEM127 0 0 0 177 1 1
BCR CASC5 0 0 358 358 1 1
BCR BDP1 0 0 381 381 1 1
BCR ARHGEF28 0 0 44 175 1 1
BCR PIK3R3 0 0 243 264 1 1
BCR PTPMT1 0 0 94 158 1 1
BCR FHL2 0 0 0 232 1 1
BCR TCL1B 0 0 410 410 1 1
BCR SAMD4B 237 0 0 237 1 1
BCR OEBT 0 0 0 232 1 1
BCR FHDC1 0 0 0 265 1 1
BCR BRCA1 0 0 204 289 1 2
BCR RSG1 0 0 0 169 1 1
BCR ZNF280B 0 0 113 248 1 1
BCR TCF3 0 0 241 256 1 1
BCR CHN2 0 0 0 201 1 1
BCR MAP2K1 0 0 162 180 1 1
BCR FUT4 0 0 249 248 1 1
BCR TOP2A 0 0 306 306 1 1
BCR PAK7 0 0 0 242 1 1
BCR THOC3 0 0 53 199 1 1
BCR EML4 0 0 320 345 1 1
BCR BAP1 0 0 117 157 1 1
BCR PLCG2 0 900 81 904 1 1
BCR ARL14 0 0 0 166 1 1
BCR UBQLN4 0 0 0 175 1 1
BCR NDN 0 0 293 293 1 1
BCR CALB2 0 0 0 190 1 1
BCR RUNX1T1 0 0 324 323 1 1
BCR GRB10 213 0 52 222 1 1
BCR ARF1 0 0 0 166 1 1
BCR UROD 0 0 324 323 1 1
BCR RHOBTB2 0 0 112 351 1 1
BCR ARHGEF39 107 0 0 201 1 1
BCR ARL3 0 0 0 166 1 1
BCR GRID2IP 0 0 0 265 1 1
BCR PLK1 120 0 108 214 1 2
BCR EPO 0 0 134 173 1 2
BCR CCNB1 0 0 67 179 1 1
BCR GGT2 0 0 113 346 1 1
BCR ANXA5 0 0 214 268 1 2
BCR RHOJ 0 0 91 311 1 1
BCR SPECC1L 0 0 108 201 1 1
BCR VNN3 0 0 408 467 1 1
BCR HSPD1 270 0 0 270 1 1
BCR MGMT 0 0 125 153 1 2
BCR DNMT3A 0 0 157 156 1 2
BCR MMAA 0 0 0 563 1 1
BCR CD7 0 0 273 273 1 1
BCR EVPL 0 0 710 716 1 1
BCR AFF3 0 0 294 309 1 1
BCR BCL2L1 0 0 263 263 1 2
BCR FHL5 0 0 0 232 1 1
BCR KITLG 0 0 194 194 1 1
BCR THSD7A 0 0 70 482 1 1
BCR ARHGEF18 0 0 0 313 1 1
BCR FBXO42 0 0 0 159 1 1
BCR RAN 0 0 202 202 1 2
BCR RAP1A 0 0 0 169 1 1
BCR ERG 0 0 82 152 1 1
BCR CYSLTR2 0 0 45 270 1 1
BCR ARL5B 0 0 0 166 1 1
BCR ABL1 766 800 943 997 1 1
BCR MAP2K7 0 0 292 292 1 1
BCR PPIE 0 0 206 211 1 1
BCR PLEKHG1 0 0 82 179 1 1
BCR EBF1 0 0 158 157 1 1
BCR ARHGAP12 0 0 0 230 1 1
BCR PML 0 0 268 277 1 2
BCR SLC20A1 0 0 500 499 1 1
BCR CD22 0 900 193 915 1 1
BCR TMBIM4 0 0 0 313 1 1
BCR RIT2 0 0 0 169 1 1
BCR ARHGEF37 0 0 0 178 1 1
BCR BCL9L 0 0 107 201 1 1
BCR ATIC 0 0 171 212 1 2
BCR GAPDH 0 0 154 153 1 2
BCR IGLL1 0 0 357 357 1 1
BCR KIAA1429 270 0 0 270 1 1
BCR USP41 0 0 0 207 1 1
BCR CNTD2 0 0 0 157 1 1
BCR ARF3 0 0 0 187 1 1
BCR HCLS1 0 0 74 171 1 1
BCR HIF1A 270 0 161 361 1 2
BCR MAGEC2 0 0 174 173 1 1
BCR DLG2 0 0 96 162 1 1
BCR VRK1 0 0 134 171 1 1
BCR PDZK1 415 0 638 782 1 1
BCR IBTK 0 900 0 904 1 1
BCR ARL1 0 0 0 166 1 1
BCR RHOBTB1 0 0 95 339 1 1
BCR DDR2 0 0 163 172 1 1
BCR ERBB2IP 270 0 430 566 1 1
BCR HRAS 0 0 288 403 1 2
BCR CTNNB1 0 0 262 268 1 2
BCR CDK2 0 0 160 221 1 2
BCR EPHA2 0 0 134 169 1 1
BCR ARL8A 0 0 0 166 1 1
BCR EXOC8 0 0 0 179 1 1
BCR RHOU 0 0 95 314 1 1
BCR AP1B1 0 0 161 200 1 1
BCR MTOR 0 900 260 924 1 2
BCR MYO9B 0 0 0 228 1 1
BCR RAD51 270 0 434 569 1 2
BCR FBXW4 0 0 389 388 1 1
BCR HEATR5A 0 0 0 160 1 1
BCR CXCR4 0 0 151 150 1 2
BCR VPREB1 0 0 397 407 1 1
BCR RRAS 0 0 0 169 1 1
BCR KAZN 0 0 0 174 1 1
BCR PRICKLE1 0 0 0 232 1 1
BCR NOTCH1 0 0 171 197 1 2
BCR FKBP15 0 0 108 153 1 1
BCR P4HTM 0 0 185 185 1 1
BCR STAT1 0 650 92 677 1 2
BCR ENDOG 0 0 155 161 1 1
BCR DYNC1LI2 0 0 89 172 1 1
BCR CCNF 0 0 0 164 1 1
BCR TNFRSF1A 0 0 332 332 1 1
BCR PLEK 0 0 302 318 1 1
BCR GGTLC3 0 0 119 350 1 1
BCR VAV2 0 900 75 903 1 1
BCR RAB12 0 0 0 291 1 2
BCR MAP3K2 0 0 0 233 1 1
BCR IL3RA 0 0 143 161 1 1
BCR SEPT6 0 0 292 318 1 1
BCR MPO 0 0 292 292 1 2
BCR CPS1 0 0 322 321 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables IEA
GO:0005096 Molecular Function GTPase activator activity enables IDA
GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity enables IDA
GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity enables IMP
GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0106310 Molecular Function protein serine kinase activity enables IEA
GO:0004674 Molecular Function protein serine/threonine kinase activity enables IEA
GO:0004713 Molecular Function protein tyrosine kinase activity enables TAS
GO:0030036 Biological Process actin cytoskeleton organization involved_in IEA
GO:0090630 Biological Process activation of GTPase activity involved_in IDA
GO:0090630 Biological Process activation of GTPase activity involved_in IMP
GO:0007420 Biological Process brain development involved_in IEA
GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IEA
GO:0060216 Biological Process definitive hemopoiesis involved_in IEA
GO:0048041 Biological Process focal adhesion assembly involved_in IMP
GO:0048872 Biological Process homeostasis of number of cells involved_in IEA
GO:0042472 Biological Process inner ear morphogenesis involved_in IEA
GO:0065002 Biological Process intracellular protein transmembrane transport involved_in IEA
GO:0030216 Biological Process keratinocyte differentiation involved_in IMP
GO:1905517 Biological Process macrophage migration involved_in IEA
GO:0050804 Biological Process modulation of chemical synaptic transmission involved_in ISS
GO:0060313 Biological Process negative regulation of blood vessel remodeling involved_in IEA
GO:0002692 Biological Process negative regulation of cellular extravasation involved_in IEA
GO:0050728 Biological Process negative regulation of inflammatory response involved_in IEA
GO:1905522 Biological Process negative regulation of macrophage migration involved_in IEA
GO:0043314 Biological Process negative regulation of neutrophil degranulation involved_in IEA
GO:2000378 Biological Process negative regulation of reactive oxygen species metabolic process involved_in IEA
GO:0060268 Biological Process negative regulation of respiratory burst involved_in IEA
GO:0050885 Biological Process neuromuscular process controlling balance involved_in IEA
GO:0043312 Biological Process neutrophil degranulation involved_in IEA
GO:0006909 Biological Process phagocytosis involved_in IEA
GO:0050766 Biological Process positive regulation of phagocytosis involved_in IEA
GO:0006468 Biological Process protein phosphorylation involved_in TAS
GO:0035023 Biological Process regulation of Rho protein signal transduction involved_in IMP
GO:0051726 Biological Process regulation of cell cycle involved_in IEA
GO:0051171 Biological Process regulation of nitrogen compound metabolic process involved_in IEA
GO:0051056 Biological Process regulation of small GTPase mediated signal transduction involved_in TAS
GO:0043114 Biological Process regulation of vascular permeability involved_in IEA
GO:0003014 Biological Process renal system process involved_in IEA
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0007264 Biological Process small GTPase mediated signal transduction involved_in IMP
GO:0098685 Cellular Component Schaffer collateral - CA1 synapse located_in ISS
GO:0030424 Cellular Component axon located_in IEA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0043197 Cellular Component dendritic spine located_in IEA
GO:0070062 Cellular Component extracellular exosome located_in HDA
GO:0098978 Cellular Component glutamatergic synapse located_in ISS
GO:0016020 Cellular Component membrane located_in HDA
GO:0016020 Cellular Component membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IEA
GO:0014069 Cellular Component postsynaptic density located_in IEA
GO:0032991 Cellular Component protein-containing complex part_of IDA
Pathways
Name DB ID
Signaling by FGFR in disease Reactome R-HSA-1226099
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
Signaling by cytosolic FGFR1 fusion mutants Reactome R-HSA-1839117
FGFR1 mutant receptor activation Reactome R-HSA-1839124
Signaling by Rho GTPases Reactome R-HSA-194315
Signaling by FGFR1 in disease Reactome R-HSA-5655302
Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
RHOA GTPase cycle Reactome R-HSA-8980692
RHO GTPase cycle Reactome R-HSA-9012999
RHOB GTPase cycle Reactome R-HSA-9013026
RHOC GTPase cycle Reactome R-HSA-9013106
CDC42 GTPase cycle Reactome R-HSA-9013148
RAC1 GTPase cycle Reactome R-HSA-9013149
RAC2 GTPase cycle Reactome R-HSA-9013404
RAC3 GTPase cycle Reactome R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Reactome R-HSA-9716542
Imatinib and chronic myeloid leukemia (WP3640) WikiPathways WP3640_r122579
Extrafollicular and follicular B cell activation by SARS-CoV-2 (WP5218) WikiPathways WP5218_r124690
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_004327 4 mRNA transcript variant 1 NC_000022 Reference
NM_021574 3 mRNA transcript variant 2 NC_000022 Reference