HAdb 2.0 is available now!

RYR1

ryanodine receptor 1
General Information
Name ryanodine receptor 1
Alias
  • ryanodine receptor 1
  • central core disease of muscle
  • protein phosphatase 1, regulatory subunit 137
  • ryanodine receptor 1 (skeletal)
  • sarcoplasmic reticulum calcium release channel
  • skeletal muscle calcium release channel
  • skeletal muscle ryanodine receptor
  • type 1-like ryanodine receptor
Gene_family Ryanodine receptors|Protein phosphatase 1 regulatory subunits
organism Homo sapiens
entrez_id 6261
location 19q13.2
transcript_count 6
exon_count 106
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Stringdb Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for nor [...]
    nextProt Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
RYR1 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
RYR1 BioGRID SOX2 GeneID BioGRID Affinity Capture-MS
RYR1 BioGRID TRDN GeneID BioGRID Far Western; Protein-peptide; Reconstituted Complex
RYR1 BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
RYR1 BioGRID UBQLN2 GeneID BioGRID Affinity Capture-MS
RYR1 BioGRID NR3C1 GeneID BioGRID Proximity Label-MS
RYR1 BioGRID PDLIM3 GeneID BioGRID Two-hybrid
RYR1 BioGRID MYOM2 GeneID BioGRID Co-localization; Two-hybrid
RYR1 BioGRID TULP3 GeneID BioGRID Two-hybrid
RYR1 BioGRID TTN GeneID BioGRID Two-hybrid
RYR1 BioGRID MTDH GeneID BioGRID Protein-RNA
RYR1 BioGRID METTL3 GeneID BioGRID Affinity Capture-MS
RYR1 BioGRID RYR2 GeneID BioGRID Affinity Capture-Western; Co-purification; Reconstituted Complex
RYR1 BioGRID AKAP6 GeneID BioGRID Reconstituted Complex
RYR1 BioGRID CALM1 GeneID BioGRID FRET; Far Western; Reconstituted Complex
RYR1 BioGRID RYR1 GeneID BioGRID Reconstituted Complex
RYR1 BioGRID CAV3 GeneID BioGRID Reconstituted Complex
RYR1 BioGRID AGR2 GeneID BioGRID Proximity Label-MS
RYR1 BioGRID RNF123 GeneID BioGRID Affinity Capture-MS
RYR1 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
RYR1 BioGRID ANK1 GeneID BioGRID Reconstituted Complex
RYR1 Protein HOMER1 GeneID HPRD
RYR1 Protein PRKG1 GeneID HPRD
RYR1 Protein HOMER3 GeneID HPRD
RYR1 Protein HOMER2 GeneID HPRD
RYR1 Protein CAMK2G GeneID HPRD
RYR1 Protein PRKACA GeneID HPRD
RYR1 Protein FKBP1A GeneID HPRD
RYR1 Protein RYR2 GeneID HPRD
RYR1 Protein RYR1 GeneID HPRD
RYR1 Protein S100A1 GeneID HPRD
RYR1 Protein CACNA1S GeneID HPRD
RYR1 Protein CALM1 GeneID HPRD
RYR1 BioGRID HOMER1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
RYR1 BioGRID HOMER2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
RYR1 BioGRID HOMER3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
RYR1 BioGRID S100A1 GeneID BioGRID Reconstituted Complex
RYR1 BioGRID FKBP1A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
RYR1 TRPM6 0 0 160 167 1 1
RYR1 AIP 0 0 49 154 1 1
RYR1 TRPC5 0 0 135 205 1 1
RYR1 CETN2 0 0 0 187 1 1
RYR1 KIF3C 0 0 120 158 1 1
RYR1 TBL1X 0 0 150 217 1 1
RYR1 SOD1 0 0 127 181 1 2
RYR1 FKBP3 0 0 142 284 1 1
RYR1 PIP5K1A 0 0 66 228 1 1
RYR1 CASQ1 0 600 673 916 1 1
RYR1 FST 0 0 165 165 1 1
RYR1 ARHGAP11A 0 0 0 173 1 1
RYR1 LAMP2 0 0 155 154 1 2
RYR1 ATP2B3 0 0 207 466 1 1
RYR1 ANK1 270 0 167 413 1 1
RYR1 RSPH6A 0 0 96 157 1 1
RYR1 RTN1 0 0 0 216 1 1
RYR1 GRIN2A 0 0 124 192 1 1
RYR1 P2RX6 0 0 141 178 1 1
RYR1 COX6C 0 0 97 159 1 1
RYR1 OR4C5 0 0 172 193 1 1
RYR1 AGRN 0 0 241 259 1 1
RYR1 PLCH2 0 0 0 253 1 1
RYR1 PRKACB 0 0 0 278 1 1
RYR1 VSNL1 0 0 0 217 1 1
RYR1 KRT8 0 0 297 309 1 1
RYR1 NFATC3 0 0 169 185 1 1
RYR1 TFAM 0 0 145 168 1 2
RYR1 RBFOX1 0 0 150 246 1 1
RYR1 GAP43 0 0 113 180 1 1
RYR1 MCOLN2 0 0 167 214 1 1
RYR1 FKBP14 0 0 113 458 1 1
RYR1 KCNMB1 0 0 171 171 1 1
RYR1 CFL2 0 0 338 353 1 1
RYR1 CALR 0 0 324 508 1 1
RYR1 CSRP2 0 0 0 183 1 1
RYR1 MFN1 0 0 154 168 1 2
RYR1 MYBPH 0 0 52 168 1 1
RYR1 SYNJ2BP 0 0 74 178 1 1
RYR1 MCOLN3 0 0 141 200 1 1
RYR1 SLC8A1 0 0 386 431 1 1
RYR1 HPCAL1 0 0 0 187 1 1
RYR1 CAV1 0 0 712 716 1 2
RYR1 AIF1 0 0 0 187 1 2
RYR1 PHF12 0 0 108 179 1 1
RYR1 COLQ 0 0 262 295 1 1
RYR1 NOS1 0 800 532 904 1 1
RYR1 RASA4B 0 0 0 212 1 1
RYR1 ERICH3 0 0 113 190 1 1
RYR1 CIB4 0 0 46 191 1 1
RYR1 SNCA 0 0 123 162 1 2
RYR1 MYL7 0 0 117 301 1 1
RYR1 UBE3C 0 0 56 155 1 1
RYR1 FABP3 0 0 162 217 1 1
RYR1 CNTNAP4 0 0 135 224 1 1
RYR1 ITPR3 0 0 687 469 1 1
RYR1 SCN3A 0 0 54 262 1 1
RYR1 CNGA1 0 0 154 175 1 1
RYR1 PLCG1 131 0 72 232 1 1
RYR1 SIGLEC1 0 0 48 219 1 1
RYR1 CALB1 0 0 154 301 1 1
RYR1 SLC8A2 0 0 72 203 1 1
RYR1 CATSPERD 0 720 0 720 1 1
RYR1 MYH7B 0 0 281 414 1 1
RYR1 KCNN1 0 0 104 208 1 1
RYR1 OR6X1 0 0 172 171 1 1
RYR1 PLCB4 0 0 44 261 1 1
RYR1 SYT1 0 0 125 154 1 1
RYR1 CHRM1 0 0 0 171 1 1
RYR1 SLC6A6 0 0 129 150 1 1
RYR1 HAPLN3 0 0 137 208 1 1
RYR1 FXYD1 0 0 103 216 1 1
RYR1 KBTBD13 0 0 563 563 1 1
RYR1 ACTN3 0 0 385 519 1 1
RYR1 ABCA4 0 0 73 181 1 1
RYR1 COX4I1 0 0 95 174 1 1
RYR1 PSEN1 0 0 155 254 1 2
RYR1 CALHM1 0 0 108 200 1 1
RYR1 PDIA2 0 0 0 184 1 1
RYR1 S100A11 0 0 60 189 1 1
RYR1 TMEM70 0 0 167 224 1 1
RYR1 HPGDS 0 0 735 735 1 1
RYR1 MYO9A 0 0 96 202 1 1
RYR1 ATP8B1 0 0 0 219 1 1
RYR1 MYL12B 0 0 157 301 1 1
RYR1 ANGPT1 0 0 55 200 1 1
RYR1 KMT2C 0 0 96 235 1 1
RYR1 ENO3 0 0 170 206 1 1
RYR1 CAPN12 0 0 123 164 1 1
RYR1 HMCN2 0 0 0 202 1 1
RYR1 KCNH3 0 0 0 157 1 1
RYR1 ACTB 0 0 240 256 1 2
RYR1 INS 0 0 267 267 1 2
RYR1 TNNT1 0 0 414 474 1 1
RYR1 CHRNB1 0 0 155 184 1 1
RYR1 CTTN 0 0 270 270 1 1
RYR1 CKMT1A 0 0 0 224 1 1
RYR1 TES 0 0 211 346 1 1
RYR1 CACNB1 0 540 426 750 1 1
RYR1 KCNT1 0 0 163 252 1 1
RYR1 CAV2 0 0 202 211 1 1
RYR1 TNNI3 0 0 203 397 1 1
RYR1 RCN2 0 0 95 223 1 1
RYR1 PGAM2 0 0 287 359 1 1
RYR1 SCN7A 0 0 74 201 1 1
RYR1 MYL1 0 0 214 372 1 1
RYR1 TPM1 0 0 209 315 1 1
RYR1 MAT2B 0 0 59 205 1 1
RYR1 ERP44 0 0 172 309 1 1
RYR1 HRC 0 0 261 342 1 1
RYR1 SCN1B 0 0 132 178 1 1
RYR1 KCNH2 0 0 321 444 1 1
RYR1 TEX40 0 720 0 720 1 1
RYR1 INSR 0 0 216 221 1 1
RYR1 MYH9 0 0 162 309 1 1
RYR1 UNC80 0 0 48 204 1 1
RYR1 AKAP9 0 0 81 222 1 1
RYR1 PDK2 0 0 103 174 1 1
RYR1 SMDT1 0 0 161 161 1 1
RYR1 CKM 0 0 384 511 1 1
RYR1 B3GALNT2 0 0 181 182 1 1
RYR1 EHHADH 0 0 436 436 1 1
RYR1 POLG 0 0 161 161 1 1
RYR1 ABCC8 0 0 181 310 1 1
RYR1 ATP8B2 0 0 0 219 1 1
RYR1 ATP10A 0 0 0 219 1 1
RYR1 ATP2A1 0 0 767 928 1 1
RYR1 DNM2 0 0 567 598 1 1
RYR1 SLC24A1 0 0 74 218 1 1
RYR1 CALML6 0 600 0 661 1 1
RYR1 SPEF2 0 0 206 236 1 1
RYR1 SPAST 0 0 126 398 1 1
RYR1 HTR1A 0 0 0 164 1 1
RYR1 CABP5 0 0 0 187 1 1
RYR1 SGCB 0 0 282 370 1 1
RYR1 PLCD4 0 0 159 303 1 1
RYR1 ZYX 0 0 66 154 1 1
RYR1 PDE4A 0 0 74 259 1 1
RYR1 BCHE 0 0 171 195 1 1
RYR1 FKBP5 0 0 109 256 1 1
RYR1 FAM26F 0 0 0 162 1 1
RYR1 TMC1 0 0 107 491 1 1
RYR1 PTPRJ 0 0 95 238 1 1
RYR1 CABP4 0 0 43 189 1 1
RYR1 TPM4 0 0 51 178 1 1
RYR1 CALML3 0 600 45 662 1 1
RYR1 EFCAB1 0 0 0 187 1 1
RYR1 ZNF862 0 0 134 211 1 1
RYR1 CLCN1 0 0 520 549 1 1
RYR1 FNDC5 0 0 95 202 1 1
RYR1 USP32 0 0 0 188 1 1
RYR1 PDE4D 270 540 171 742 1 1
RYR1 FKBP4 0 0 142 284 1 1
RYR1 KCNC4 0 0 103 220 1 1
RYR1 KRT72 0 0 0 161 1 1
RYR1 PRPH2 0 0 203 203 1 1
RYR1 ACTC1 0 0 234 265 1 1
RYR1 KCNIP3 0 0 0 187 1 1
RYR1 ATP13A4 0 0 0 241 1 1
RYR1 SLC24A2 0 0 0 211 1 1
RYR1 OCM2 0 0 92 230 1 1
RYR1 TMOD4 0 0 160 213 1 1
RYR1 HVCN1 0 0 143 155 1 1
RYR1 PLCL2 0 0 0 167 1 1
RYR1 DAG1 0 0 325 325 1 1
RYR1 CACNG7 0 720 0 745 1 1
RYR1 CASQ2 0 600 465 832 1 1
RYR1 GPR98 0 0 154 191 1 1
RYR1 CPNE9 0 0 0 188 1 1
RYR1 CTNNA3 0 0 73 160 1 1
RYR1 RNF123 270 0 0 270 1 1
RYR1 MBNL3 0 0 181 181 1 1
RYR1 MYLK 0 0 261 329 1 1
RYR1 SMAD3 0 0 134 152 1 2
RYR1 TRPM4 0 0 235 244 1 1
RYR1 HCFC1 0 0 0 167 1 1
RYR1 CALU 0 0 57 278 1 1
RYR1 SNTB2 0 0 81 219 1 1
RYR1 NOTCH3 0 0 0 161 1 1
RYR1 MFSD3 0 0 157 208 1 1
RYR1 HERPUD1 0 0 359 359 1 1
RYR1 CLEC3A 0 0 95 209 1 1
RYR1 SNTA1 0 0 438 463 1 1
RYR1 PGK1 0 0 56 202 1 2
RYR1 PVALB 0 0 380 520 1 1
RYR1 BAIAP3 0 0 155 182 1 1
RYR1 UTRN 0 0 391 472 1 1
RYR1 ALB 0 0 287 360 1 2
RYR1 SORCS3 0 0 0 297 1 1
RYR1 ABCC3 0 0 0 153 1 1
RYR1 TXNDC16 0 0 0 257 1 1
RYR1 CALML5 0 600 0 671 1 1
RYR1 FAM103A1 0 0 0 185 1 1
RYR1 HPCAL4 0 0 135 321 1 1
RYR1 GNAS 0 0 86 209 1 1
RYR1 PPARA 0 0 305 305 1 2
RYR1 SLC8A3 0 0 260 344 1 1
RYR1 ACHE 0 0 185 249 1 2
RYR1 CEBPD 0 0 213 213 1 1
RYR1 ATP2C2 0 0 95 461 1 1
RYR1 MYOM1 0 0 229 398 1 1
RYR1 KLHL41 0 0 324 352 1 1
RYR1 TRPC6 0 0 310 351 1 1
RYR1 GRAMD1A 0 0 90 152 1 1
RYR1 ATL3 0 0 92 154 1 1
RYR1 CRHR1 0 0 0 162 1 1
RYR1 TMX1 0 0 138 258 1 1
RYR1 CEP250 0 0 66 210 1 1
RYR1 CKMT2 0 0 124 447 1 1
RYR1 PDE2A 0 0 136 236 1 1
RYR1 ALPK1 0 0 150 181 1 1
RYR1 ZDHHC13 0 0 91 253 1 1
RYR1 MC1R 0 0 93 177 1 1
RYR1 KCNH6 0 0 0 195 1 1
RYR1 MUC16 0 0 96 152 1 1
RYR1 CFD 0 0 0 303 1 1
RYR1 IQSEC3 0 0 92 157 1 1
RYR1 CFAP46 0 0 112 161 1 1
RYR1 SORCS2 0 0 0 207 1 1
RYR1 NKAIN3 0 0 174 173 1 1
RYR1 SLC8B1 0 0 320 366 1 1
RYR1 PRTN3 0 0 0 190 1 1
RYR1 CACNB3 0 720 74 747 1 1
RYR1 CTIF 0 0 75 359 1 1
RYR1 NRXN2 0 0 0 174 1 1
RYR1 GCN1L1 0 0 149 240 1 1
RYR1 MYL12A 0 0 143 289 1 1
RYR1 CYCS 0 0 181 181 1 2
RYR1 TTI2 0 0 0 211 1 1
RYR1 MTM1 0 0 688 732 1 2
RYR1 ITPR1 0 0 717 478 1 2
RYR1 NMRK2 0 0 93 200 1 1
RYR1 LIX1L 0 0 118 215 1 1
RYR1 PPP3R2 0 0 0 187 1 1
RYR1 DNAH5 0 0 108 217 1 1
RYR1 CHERP 0 0 254 331 1 1
RYR1 CAPZA2 0 0 67 164 1 1
RYR1 ITGA7 0 0 483 521 1 1
RYR1 ACTN2 0 0 500 606 1 1
RYR1 CLIC2 0 0 613 652 1 1
RYR1 LDB3 0 0 456 493 1 1
RYR1 TRPM8 0 0 175 181 1 1
RYR1 CATSPER2 0 720 74 773 1 1
RYR1 PYGM 0 0 457 496 1 1
RYR1 SCAF8 0 0 86 177 1 1
RYR1 MYLPF 0 0 321 504 1 1
RYR1 SLC43A3 0 0 0 177 1 1
RYR1 CORIN 0 0 0 206 1 1
RYR1 FKBP1A 766 720 989 999 1 2
RYR1 DYNC2H1 0 0 233 250 1 1
RYR1 CALML4 0 600 0 661 1 1
RYR1 RASA4 0 0 0 212 1 1
RYR1 HNRNPA2B1 0 0 166 165 1 1
RYR1 RCN3 0 0 95 152 1 1
RYR1 TANGO2 0 0 133 152 1 1
RYR1 TPM2 0 0 465 537 1 1
RYR1 JSRP1 0 0 678 692 1 1
RYR1 SRL 0 0 557 605 1 1
RYR1 VPS18 0 0 305 305 1 1
RYR1 SPATA21 0 0 0 187 1 1
RYR1 VR1 0 0 478 489 1 1
RYR1 BVES 0 0 181 249 1 1
RYR1 STIM2 0 0 416 517 1 1
RYR1 PPIF 0 0 212 221 1 1
RYR1 DNHD1 0 0 109 218 1 1
RYR1 RTN2 0 0 84 240 1 1
RYR1 ARHGAP11B 0 0 0 173 1 1
RYR1 PFKM 0 0 122 171 1 1
RYR1 RSPH1 0 0 0 281 1 1
RYR1 STK11 0 0 86 179 1 2
RYR1 BRCA1 0 0 135 151 1 2
RYR1 FKBP7 0 0 113 294 1 1
RYR1 PRSS22 0 0 95 172 1 1
RYR1 FKBP11 0 0 0 236 1 1
RYR1 SPEG 0 0 0 150 1 1
RYR1 SPRY3 0 0 422 513 1 1
RYR1 NFIX 0 0 181 181 1 1
RYR1 DSG2 0 0 142 235 1 1
RYR1 MTMR2 0 0 445 462 1 1
RYR1 MECP2 0 0 83 181 1 1
RYR1 LMTK3 0 0 0 160 1 1
RYR1 ATP13A5 0 0 0 219 1 1
RYR1 MYL9 0 0 150 295 1 1
RYR1 NOXA1 0 0 62 157 1 1
RYR1 KCNN3 0 0 93 154 1 1
RYR1 ANO1 0 0 142 196 1 1
RYR1 ACTA1 0 0 519 531 1 1
RYR1 YIPF7 0 0 113 196 1 1
RYR1 SRI 0 0 456 555 1 1
RYR1 HIST1H1A 0 0 186 186 1 1
RYR1 LRP1B 0 0 113 179 1 1
RYR1 MFSD2B 0 0 0 461 1 1
RYR1 SPARCL1 0 0 0 152 1 1
RYR1 MEF2D 0 0 202 249 1 2
RYR1 JPH3 0 360 427 700 1 1
RYR1 CACNA1S 213 720 989 998 1 1
RYR1 SYNC 0 0 538 538 1 1
RYR1 RP1L1 0 0 129 286 1 1
RYR1 TTN 62 0 613 666 1 1
RYR1 SDK1 0 0 180 238 1 1
RYR1 FLNA 0 0 95 161 1 1
RYR1 CCDC3 0 0 94 170 1 1
RYR1 CACNB4 0 720 74 740 1 1
RYR1 MICU1 0 0 455 472 1 1
RYR1 TRDN 765 800 973 998 1 1
RYR1 CASC5 0 0 0 294 1 1
RYR1 TMCO1 0 0 120 186 1 1
RYR1 PLCB2 0 0 66 296 1 1
RYR1 HEG1 0 0 166 249 1 1
RYR1 SERPINA5 0 0 134 282 1 1
RYR1 CETN3 0 0 0 187 1 1
RYR1 TSFM 0 0 70 626 1 1
RYR1 MYH10 0 0 208 347 1 1
RYR1 ADORA1 0 0 125 164 1 1
RYR1 EGLN3 0 0 203 203 1 1
RYR1 MSRA 0 0 171 171 1 1
RYR1 GNAQ 0 0 97 166 1 1
RYR1 SCN2A 0 0 142 350 1 1
RYR1 OBSCN 0 0 400 483 1 1
RYR1 CIB2 0 0 53 200 1 1
RYR1 P4HB 0 0 139 261 1 2
RYR1 CACNG6 0 720 0 728 1 1
RYR1 FKBP1B 0 600 986 996 1 1
RYR1 RASAL1 0 0 0 269 1 1
RYR1 CIB3 0 0 0 187 1 1
RYR1 PPARGC1A 0 0 265 266 1 2
RYR1 IGF1R 0 0 156 162 1 2
RYR1 PLCB3 0 0 0 259 1 1
RYR1 ABCC2 0 0 0 153 1 1
RYR1 CAPN3 0 0 504 541 1 1
RYR1 NDUFA11 0 0 108 163 1 1
RYR1 CKMT1B 0 0 0 225 1 1
RYR1 PAX7 0 0 240 286 1 1
RYR1 TLN1 0 0 0 179 1 1
RYR1 PLCL1 0 0 0 188 1 1
RYR1 CPT2 0 0 342 387 1 1
RYR1 KCNH7 0 0 0 195 1 1
RYR1 RHBDL3 0 0 0 235 1 1
RYR1 M1AP 0 0 120 175 1 1
RYR1 PTN 0 0 0 400 1 1
RYR1 FREM3 0 0 0 189 1 1
RYR1 PRKAR2A 0 0 49 168 1 1
RYR1 MCOLN1 0 0 285 326 1 2
RYR1 MYH6 0 0 518 603 1 1
RYR1 TXNDC8 0 0 0 153 1 1
RYR1 ABCA3 0 0 0 166 1 1
RYR1 PHKB 0 0 164 250 1 1
RYR1 EFCAB2 0 0 0 187 1 1
RYR1 LRRC17 0 0 0 156 1 1
RYR1 FREM2 0 0 0 199 1 1
RYR1 ATP2B4 0 0 260 471 1 1
RYR1 SLC26A5 0 0 57 155 1 1
RYR1 PPARD 0 0 357 357 1 1
RYR1 DAW1 0 0 96 256 1 1
RYR1 CACNA1F 0 720 260 854 1 1
RYR1 ATP8B4 0 0 0 219 1 1
RYR1 ENC1 0 0 0 216 1 1
RYR1 CATSPER4 0 720 82 768 1 1
RYR1 TNNC1 0 0 134 314 1 1
RYR1 CALM3 800 0 335 949 1 1
RYR1 CAMKK2 0 0 218 239 1 2
RYR1 HMCN1 0 0 66 223 1 1
RYR1 CACNA1D 0 720 414 884 1 1
RYR1 PTPN4 0 0 122 152 1 1
RYR1 TNNT3 0 0 405 515 1 1
RYR1 ASPH 0 800 861 974 1 1
RYR1 PRKX 0 0 0 251 1 1
RYR1 PRKACG 0 0 0 278 1 1
RYR1 MCAT 0 0 183 312 1 1
RYR1 ORAI1 0 0 470 529 1 1
RYR1 PLP1 0 0 0 165 1 1
RYR1 CSPP1 0 0 123 183 1 1
RYR1 GUK1 0 0 144 167 1 1
RYR1 MYL6 0 0 116 252 1 1
RYR1 PDZD4 0 0 0 192 1 1
RYR1 OCM 0 0 90 229 1 1
RYR1 MYOT 0 0 392 459 1 1
RYR1 LMNA 0 0 323 337 1 2
RYR1 MYL10 0 0 143 289 1 1
RYR1 HTT 0 0 134 150 1 2
RYR1 ATP2C1 0 0 89 458 1 1
RYR1 HOMER2 270 0 158 382 1 1
RYR1 MARS 0 0 0 190 1 1
RYR1 EFCAB6 0 0 0 187 1 1
RYR1 SCN10A 0 0 74 206 1 1
RYR1 FLNB 0 0 46 150 1 1
RYR1 S100A1 270 0 977 993 1 1
RYR1 CFTR 0 0 195 466 1 2
RYR1 SGCG 0 0 294 315 1 1
RYR1 MIF4GD 0 0 0 175 1 1
RYR1 MYH14 0 0 242 354 1 1
RYR1 TP53 0 0 218 218 1 2
RYR1 HECTD2 0 0 218 239 1 1
RYR1 KCNMA1 0 0 270 400 1 1
RYR1 PLEK 0 0 142 150 1 1
RYR1 CATSPER1 0 720 206 812 1 1
RYR1 MYOG 0 0 370 398 1 1
RYR1 MYL6B 0 0 208 330 1 1
RYR1 KCNJ9 0 0 86 151 1 1
RYR1 SBK1 0 0 0 153 1 1
RYR1 MTMR7 0 0 95 245 1 1
RYR1 KCNA5 0 0 92 167 1 1
RYR1 HHATL 0 0 0 198 1 1
RYR1 NALCN 0 0 135 328 1 1
RYR1 JPH4 0 360 469 703 1 1
RYR1 SMN1 0 0 171 171 1 1
RYR1 CHP1 0 0 0 187 1 1
RYR1 PRKG1 213 0 180 458 1 1
RYR1 PIK3C3 0 0 81 234 1 2
RYR1 MAPRE1 0 0 58 152 1 1
RYR1 UCP2 0 0 260 290 1 2
RYR1 HSD11B1L 0 0 112 167 1 1
RYR1 CALM1 966 0 345 993 1 1
RYR1 SORT1 0 0 47 189 1 1
RYR1 GNE 0 0 284 284 1 1
RYR1 DNAH7 0 0 140 160 1 1
RYR1 MYLK2 0 0 391 419 1 1
RYR1 TRPV6 0 0 212 263 1 1
RYR1 KCNJ14 0 0 96 158 1 1
RYR1 KCNH1 0 0 81 217 1 1
RYR1 MTOR 0 0 171 177 1 2
RYR1 FKBP15 0 0 0 200 1 1
RYR1 HCN2 0 0 60 158 1 1
RYR1 MYL5 0 0 149 294 1 1
RYR1 NOTCH1 0 0 124 181 1 2
RYR1 GUCA1C 0 0 0 187 1 1
RYR1 PSEN2 0 0 91 244 1 1
RYR1 GCA 0 0 0 256 1 1
RYR1 PRSS55 0 0 113 206 1 1
RYR1 NOC2L 0 0 57 354 1 1
RYR1 CACNA2D2 0 540 102 631 1 1
RYR1 HCN4 0 0 141 225 1 1
RYR1 CACNA1C 0 720 774 955 1 1
RYR1 PRKAR2B 0 0 0 161 1 1
RYR1 PACS2 0 0 134 156 1 1
RYR1 PRR26 0 0 208 208 1 1
RYR1 ENSG00000270249 0 0 0 212 1 1
RYR1 NUSAP1 0 0 0 189 1 1
RYR1 MYOM2 94 0 226 343 1 1
RYR1 SNX18 0 0 0 177 1 1
RYR1 PASK 0 0 140 293 1 1
RYR1 EFCAB3 0 0 0 187 1 1
RYR1 POMGNT2 0 0 155 154 1 1
RYR1 SCN1A 0 0 142 331 1 1
RYR1 TRPV1 0 0 335 349 1 2
RYR1 LIPE 0 0 351 351 1 1
RYR1 KLHL9 0 0 149 170 1 1
RYR1 MUSTN1 0 0 117 374 1 1
RYR1 MFN2 0 0 272 284 1 2
RYR1 APP 0 0 141 231 1 2
RYR1 MYF5 0 0 260 287 1 1
RYR1 CDH20 0 0 95 176 1 1
RYR1 KCNJ8 0 0 195 209 1 1
RYR1 CTSL 0 0 247 246 1 2
RYR1 KCNQ1 0 0 241 240 1 1
RYR1 KCNU1 0 0 67 201 1 1
RYR1 DOK7 0 0 325 339 1 1
RYR1 MTMR6 0 0 108 170 1 1
RYR1 DLX4 0 0 54 199 1 1
RYR1 UNC79 0 0 143 276 1 1
RYR1 MYBPC3 0 0 245 346 1 1
RYR1 SEC11C 0 0 0 190 1 1
RYR1 CNBP 0 0 335 335 1 1
RYR1 SGCD 0 0 385 413 1 1
RYR1 SP1 0 0 309 321 1 2
RYR1 ANKRD23 0 0 66 150 1 1
RYR1 CACNG3 0 720 0 750 1 1
RYR1 KCNIP2 0 0 66 264 1 1
RYR1 SMAD9 0 0 150 168 1 1
RYR1 EDN1 0 0 150 188 1 1
RYR1 TRPM7 0 0 205 211 1 1
RYR1 POMT1 0 0 165 165 1 1
RYR1 GPR144 0 0 143 273 1 1
RYR1 ATP8A2 0 0 0 242 1 1
RYR1 NOS2 0 0 385 384 1 2
RYR1 DACT1 0 0 122 575 1 1
RYR1 FKBP8 0 0 53 226 1 1
RYR1 KCNB1 0 0 142 185 1 2
RYR1 GGCT 0 0 72 444 1 1
RYR1 TMEM63B 0 0 166 218 1 1
RYR1 ATIC 0 0 52 198 1 2
RYR1 GSTO1 0 0 705 705 1 1
RYR1 GAPDH 0 0 324 323 1 2
RYR1 CHD7 0 0 155 155 1 1
RYR1 TRPC3 0 0 760 774 1 1
RYR1 FGFR2 0 0 66 168 1 1
RYR1 OR7C1 0 0 152 151 1 1
RYR1 KCNC1 0 0 171 253 1 1
RYR1 MYPN 0 0 170 491 1 1
RYR1 MFAP2 0 0 59 264 1 1
RYR1 TPCN1 0 0 392 509 1 1
RYR1 KCNIP4 0 0 108 266 1 1
RYR1 BNC2 0 0 122 172 1 1
RYR1 ALDOA 0 0 150 168 1 1
RYR1 TRIM72 0 0 323 348 1 1
RYR1 ABLIM2 0 0 0 178 1 1
RYR1 ZIC1 0 0 0 332 1 1
RYR1 PCLO 0 0 124 175 1 1
RYR1 ITPR2 0 0 602 435 1 1
RYR1 PTPLA 0 0 170 196 1 1
RYR1 GJB6 0 0 56 153 1 1
RYR1 GSTM3 0 0 0 261 1 1
RYR1 CHRNA4 0 0 90 212 1 1
RYR1 CACNA1G 0 540 345 772 1 1
RYR1 WIF1 0 0 0 169 1 1
RYR1 EPO 0 0 50 182 1 2
RYR1 PLEC 0 0 150 184 1 1
RYR1 CA2 0 0 108 163 1 1
RYR1 DPAGT1 0 0 134 161 1 1
RYR1 CA3 0 0 113 184 1 2
RYR1 U2AF1L4 0 0 308 307 1 1
RYR1 TBC1D3E 0 0 245 244 1 1
RYR1 DTNA 0 0 430 444 1 1
RYR1 NCS1 0 0 74 215 1 1
RYR1 CACNG1 0 720 328 815 1 1
RYR1 ROGDI 0 0 108 183 1 1
RYR1 CACNA2D4 0 720 0 737 1 1
RYR1 FBXO32 0 0 292 308 1 2
RYR1 HSPB6 0 0 90 171 1 1
RYR1 AKAP12 0 0 0 189 1 1
RYR1 TRPC1 0 0 470 505 1 1
RYR1 ATP13A1 0 0 0 219 1 1
RYR1 GRIA4 0 0 357 390 1 1
RYR1 EPB41L3 0 0 0 207 1 1
RYR1 RYR3 0 800 937 941 1 1
RYR1 FLNC 0 0 342 390 1 1
RYR1 GRIA2 0 0 90 155 1 1
RYR1 UNC13C 0 0 85 162 1 1
RYR1 TMTC3 0 0 125 193 1 1
RYR1 MYOM3 0 0 112 164 1 1
RYR1 ELOVL2 0 0 203 252 1 1
RYR1 CREB1 0 0 202 202 1 2
RYR1 MYH3 0 0 393 498 1 1
RYR1 LMOD3 0 0 377 446 1 1
RYR1 SDF4 0 0 233 239 1 1
RYR1 ACOT4 0 0 66 166 1 1
RYR1 RAPGEF3 0 0 139 188 1 1
RYR1 ATP1A3 0 0 67 278 1 1
RYR1 ADCY9 0 0 0 153 1 1
RYR1 FIG4 0 0 101 199 1 1
RYR1 KCNC3 0 0 57 178 1 1
RYR1 TPCN2 0 0 469 542 1 1
RYR1 RYR2 486 800 968 955 1 1
RYR1 FRAS1 0 0 102 188 1 1
RYR1 KCNJ11 0 0 207 255 1 1
RYR1 CALB2 0 0 131 269 1 1
RYR1 PRKACA 213 0 0 407 1 1
RYR1 PIEZO2 0 0 123 185 1 1
RYR1 TRAPPC2 0 0 90 231 1 1
RYR1 MSTN 0 0 401 415 1 1
RYR1 SMPX 0 0 128 188 1 1
RYR1 CCDC78 0 0 517 521 1 1
RYR1 AQP4 0 0 329 410 1 1
RYR1 MBNL2 0 0 276 280 1 1
RYR1 U2AFBP 0 0 296 296 1 1
RYR1 MTFR2 0 0 112 206 1 1
RYR1 TNNI1 0 0 218 430 1 1
RYR1 CCT7 0 0 71 212 1 1
RYR1 CYP2A13 0 0 430 430 1 1
RYR1 CACNA1I 0 360 61 562 1 1
RYR1 SGCA 0 0 458 602 1 1
RYR1 CAMK4 0 0 157 195 1 1
RYR1 FKBP10 0 0 134 730 1 1
RYR1 MYO3B 0 0 75 177 1 1
RYR1 HAX1 0 0 294 294 1 1
RYR1 MYH13 0 0 294 401 1 1
RYR1 SEC11A 0 0 0 190 1 1
RYR1 LGALS12 0 0 0 210 1 1
RYR1 HSPA5 0 0 202 213 1 2
RYR1 DNM1 0 0 112 165 1 1
RYR1 POMGNT1 0 0 264 264 1 1
RYR1 UNC50 0 0 0 250 1 1
RYR1 NCALD 0 0 0 187 1 1
RYR1 ORAI3 0 0 294 416 1 1
RYR1 DNAJC10 0 0 0 257 1 1
RYR1 POMK 0 0 155 154 1 1
RYR1 ABCC1 0 0 0 153 1 1
RYR1 MTMR12 0 0 194 227 1 1
RYR1 SNAPIN 0 0 466 564 1 1
RYR1 CMYA5 0 0 171 348 1 1
RYR1 CLMP 0 0 142 271 1 1
RYR1 GYS1 0 0 260 329 1 1
RYR1 MICU3 0 0 245 295 1 1
RYR1 ENSG00000259040 0 0 0 257 1 1
RYR1 POMT2 0 0 147 188 1 1
RYR1 CAMK2B 0 0 234 355 1 1
RYR1 ABCB1 0 0 54 211 1 2
RYR1 NR6A1 0 0 95 157 1 1
RYR1 MYO16 0 0 74 189 1 1
RYR1 TMX4 0 0 0 153 1 1
RYR1 MAPT 0 0 113 151 1 2
RYR1 PDIA3 0 0 150 267 1 1
RYR1 CLIC1 0 0 175 228 1 1
RYR1 LPIN1 0 0 167 185 1 2
RYR1 GLIS3 0 0 74 193 1 1
RYR1 KCNMB3 0 0 141 370 1 1
RYR1 MYH11 0 0 204 354 1 1
RYR1 SCN8A 0 0 108 304 1 1
RYR1 CAV3 270 0 690 771 1 1
RYR1 FKBP9 0 0 46 240 1 1
RYR1 TTC26 0 0 0 167 1 1
RYR1 ATP1A1 0 0 73 245 1 1
RYR1 REM2 0 0 170 176 1 1
RYR1 ACADVL 0 0 242 241 1 1
RYR1 ST6GAL2 0 0 71 278 1 1
RYR1 ADCYAP1R1 0 0 0 238 1 1
RYR1 LDHC 0 0 54 318 1 1
RYR1 GSTM2 0 0 210 210 1 1
RYR1 KCNIP1 0 0 0 217 1 1
RYR1 CASP3 0 0 193 193 1 2
RYR1 CHP2 0 0 0 187 1 1
RYR1 PDIA6 0 0 47 262 1 1
RYR1 MYH7 0 0 520 624 1 1
RYR1 WFIKKN2 0 0 0 165 1 1
RYR1 HADH 0 0 415 414 1 1
RYR1 RGN 0 0 95 245 1 1
RYR1 HSPB8 0 0 113 162 1 2
RYR1 REL 0 0 154 153 1 2
RYR1 GYG1 0 0 92 208 1 1
RYR1 EGLN1 0 0 118 173 1 1
RYR1 TMEM38B 0 0 234 292 1 1
RYR1 FAM181A 0 0 134 172 1 1
RYR1 GFPT1 0 0 160 159 1 1
RYR1 TNN 0 0 75 152 1 1
RYR1 ENSG00000160201 0 0 296 296 1 1
RYR1 P2RX3 0 0 174 180 1 1
RYR1 MYH8 0 0 320 474 1 1
RYR1 GMPPB 0 0 293 293 1 1
RYR1 PTCHD3 0 0 46 254 1 1
RYR1 TRPC4 0 0 369 406 1 1
RYR1 GRM1 0 0 138 179 1 1
RYR1 CACNA2D3 0 540 0 604 1 1
RYR1 SACS 0 0 107 436 1 1
RYR1 CYBB 0 0 282 320 1 2
RYR1 COL6A2 0 0 194 204 1 1
RYR1 TMOD1 0 0 193 222 1 1
RYR1 SRPK3 0 0 142 203 1 1
RYR1 ACE 0 0 142 165 1 1
RYR1 TNNI2 0 0 229 548 1 1
RYR1 TMC3 0 0 0 159 1 1
RYR1 CACNA1H 0 720 278 846 1 1
RYR1 NME9 0 0 0 153 1 1
RYR1 TRPM3 0 0 258 264 1 1
RYR1 ADAMTSL1 0 0 0 160 1 1
RYR1 CHRND 0 0 359 388 1 1
RYR1 PLCZ1 0 0 0 157 1 1
RYR1 SESTD1 0 0 0 158 1 1
RYR1 S100B 0 0 142 192 1 1
RYR1 ADCK1 0 0 98 154 1 1
RYR1 MYH1 0 0 363 666 1 1
RYR1 KCNQ2 0 0 96 180 1 1
RYR1 CALM2 800 600 0 969 1 1
RYR1 POGLUT1 0 0 145 166 1 1
RYR1 ATP1A2 0 0 194 405 1 1
RYR1 CKB 0 0 0 215 1 1
RYR1 KCNJ10 0 0 321 354 1 1
RYR1 CDH23 0 0 54 175 1 1
RYR1 RIN2 0 0 67 212 1 1
RYR1 EGFLAM 0 0 75 156 1 1
RYR1 TRPV5 0 0 180 215 1 1
RYR1 GPI 0 0 357 385 1 2
RYR1 CRYAB 0 0 139 184 1 2
RYR1 PDILT 0 0 0 257 1 1
RYR1 EFCAB9 0 0 0 187 1 1
RYR1 SLC4A1 0 0 97 358 1 1
RYR1 RASA2 0 0 0 181 1 1
RYR1 POPDC2 0 0 81 205 1 1
RYR1 MEF2A 0 0 171 176 1 1
RYR1 CPNE5 0 0 0 150 1 1
RYR1 AKAP10 0 0 70 413 1 1
RYR1 STAC3 0 720 834 958 1 1
RYR1 SSPN 0 0 134 220 1 1
RYR1 LAMA2 0 0 421 420 1 1
RYR1 PDIA4 0 0 0 153 1 1
RYR1 DLG4 0 0 123 175 1 2
RYR1 ACTG1 0 0 142 179 1 1
RYR1 TMIGD1 0 0 102 176 1 1
RYR1 DMD 0 0 520 606 1 2
RYR1 EGLN2 0 0 147 175 1 1
RYR1 PAPLN 0 0 0 150 1 1
RYR1 ATP8B3 0 0 0 219 1 1
RYR1 ABCC10 0 0 51 169 1 1
RYR1 AMPD1 0 0 335 382 1 1
RYR1 GFAP 0 0 59 177 1 2
RYR1 ASPM 0 0 124 398 1 1
RYR1 CLIP3 0 0 89 170 1 1
RYR1 PIEZO1 0 0 180 191 1 1
RYR1 PPP3R1 0 0 46 191 1 1
RYR1 TRAPPC2P1 0 0 0 190 1 1
RYR1 TBC1D8 0 0 113 168 1 1
RYR1 KCNA2 0 0 234 324 1 1
RYR1 KCNA3 0 0 96 210 1 1
RYR1 PRKAG3 0 0 566 642 1 1
RYR1 OR13J1 0 0 171 191 1 1
RYR1 IGF2 0 0 260 311 1 1
RYR1 AMPH 0 0 269 299 1 1
RYR1 AIF1L 0 0 0 212 1 1
RYR1 TRIM63 0 0 258 274 1 1
RYR1 TTC28 0 0 81 174 1 1
RYR1 CSRP3 0 0 113 151 1 1
RYR1 TRIM54 0 0 181 231 1 1
RYR1 TTI1 0 0 0 288 1 1
RYR1 FAM84A 0 0 103 240 1 1
RYR1 NRXN1 0 0 73 159 1 1
RYR1 PRKG2 0 0 0 161 1 1
RYR1 ENSG00000273398 0 0 0 187 1 1
RYR1 CATSPERG 0 720 0 720 1 1
RYR1 PKD2L1 0 0 359 453 1 1
RYR1 CATSPER3 0 720 95 772 1 1
RYR1 CLIC4 0 0 157 244 1 1
RYR1 RIMS1 0 0 61 183 1 1
RYR1 FKBP2 0 0 96 280 1 1
RYR1 UCP1 0 0 202 202 1 2
RYR1 ATP1A4 0 0 73 245 1 1
RYR1 EIF4E1B 0 0 0 156 1 1
RYR1 TXNDC2 0 0 0 153 1 1
RYR1 KLHL40 0 0 460 498 1 1
RYR1 KCNJ12 0 0 171 227 1 1
RYR1 CACNG4 0 720 88 752 1 1
RYR1 TRPV3 0 0 134 172 1 1
RYR1 ACSL4 0 0 51 215 1 1
RYR1 TXN2 0 0 0 153 1 1
RYR1 TELO2 0 0 45 191 1 1
RYR1 SEC24A 0 0 122 182 1 1
RYR1 NFATC1 0 0 186 186 1 2
RYR1 SIL1 0 0 179 179 1 1
RYR1 CABP7 0 0 137 426 1 1
RYR1 HCFC2 0 0 0 167 1 1
RYR1 NME8 0 0 0 191 1 1
RYR1 DNM1L 0 0 113 165 1 2
RYR1 PLN 0 0 150 194 1 1
RYR1 MYOD1 0 0 337 369 1 1
RYR1 QDPR 0 0 989 989 1 1
RYR1 SYP 0 0 109 159 1 1
RYR1 ECHDC3 0 0 108 163 1 1
RYR1 GRIN1 0 0 77 191 1 1
RYR1 CAMTA2 0 0 151 152 1 1
RYR1 MYO7A 0 0 66 158 1 1
RYR1 CABP2 0 0 113 248 1 1
RYR1 HYDIN 0 0 55 221 1 1
RYR1 NEURL1 0 0 67 228 1 1
RYR1 CAMK2G 213 0 81 392 1 1
RYR1 PTPRZ1 0 0 61 201 1 1
RYR1 PLCD1 0 0 0 168 1 1
RYR1 F9 0 0 0 189 1 1
RYR1 SEPN1 0 0 706 785 1 1
RYR1 PLCD3 0 0 0 168 1 1
RYR1 ATP4A 0 0 82 275 1 1
RYR1 MURC 0 0 112 221 1 1
RYR1 PDIA5 0 0 0 257 1 1
RYR1 XBP1 0 0 134 195 1 2
RYR1 GBE1 0 0 208 208 1 1
RYR1 EPPK1 0 0 50 392 1 1
RYR1 MBNL1 0 0 416 416 1 1
RYR1 RBM10 0 0 57 272 1 1
RYR1 FKTN 0 0 207 207 1 1
RYR1 NOX1 0 0 134 198 1 1
RYR1 RCVRN 0 0 0 187 1 1
RYR1 COL6A6 0 0 151 161 1 1
RYR1 TXNDC5 0 0 0 257 1 1
RYR1 ADCY8 0 0 124 211 1 1
RYR1 PPP1CA 270 0 0 289 1 1
RYR1 ESR1 0 0 122 176 1 2
RYR1 GPR176 0 0 82 203 1 1
RYR1 CSRP1 0 0 0 183 1 1
RYR1 ZNF655 0 0 89 170 1 1
RYR1 HOMER1 678 0 548 854 1 1
RYR1 TRPA1 0 0 215 245 1 1
RYR1 MYL3 0 0 269 404 1 1
RYR1 BACE1 0 0 243 243 1 2
RYR1 CACHD1 0 540 0 567 1 1
RYR1 CACNA1E 0 720 260 859 1 1
RYR1 PPP1R14A 0 0 93 164 1 1
RYR1 CAMK2A 0 0 161 308 1 2
RYR1 ATP8A1 0 0 0 242 1 1
RYR1 PRKCA 0 0 140 179 1 1
RYR1 OR6C75 0 0 180 179 1 1
RYR1 ANO5 0 0 418 446 1 1
RYR1 KCNA4 0 0 103 237 1 1
RYR1 MT-CYB 0 0 66 162 1 1
RYR1 CASR 0 0 66 175 1 2
RYR1 MYH15 0 0 203 302 1 1
RYR1 MUSK 0 0 342 385 1 1
RYR1 TFDP3 0 0 451 451 1 1
RYR1 KCNN4 0 0 181 230 1 1
RYR1 ATP2B1 0 0 391 565 1 1
RYR1 NEB 0 0 456 493 1 1
RYR1 AGL 0 0 160 215 1 1
RYR1 NPC1L1 0 0 90 230 1 1
RYR1 DMWD 0 0 412 412 1 1
RYR1 ICK 0 0 60 179 1 1
RYR1 NFKBIB 0 0 166 165 1 1
RYR1 ALPK3 0 0 149 193 1 1
RYR1 TTK 0 0 93 155 1 1
RYR1 SLC24A5 0 0 46 195 1 1
RYR1 MYOZ1 0 0 194 323 1 1
RYR1 HOMER3 270 0 82 325 1 1
RYR1 ERP27 0 0 0 257 1 1
RYR1 FUT1 0 0 143 229 1 1
RYR1 HHAT 0 0 0 303 1 1
RYR1 SCN4A 0 0 519 649 1 1
RYR1 VKORC1 0 0 156 214 1 1
RYR1 CHRNE 0 0 293 313 1 1
RYR1 PGK2 0 0 54 312 1 1
RYR1 IGF1 0 0 241 240 1 2
RYR1 EPB41L1 0 0 0 207 1 1
RYR1 SYNE1 0 0 306 364 1 1
RYR1 SNRNP27 0 0 395 394 1 1
RYR1 SIX5 0 0 416 428 1 1
RYR1 CACNG2 0 720 102 762 1 1
RYR1 SPRY2 0 0 598 606 1 1
RYR1 SOX5 0 0 64 226 1 1
RYR1 RAPSN 0 0 339 339 1 1
RYR1 TNNT2 0 0 338 432 1 1
RYR1 CALN1 0 0 0 217 1 1
RYR1 ATP12A 0 0 75 247 1 1
RYR1 MYL4 0 0 181 307 1 1
RYR1 CYP2A6 0 0 388 388 1 1
RYR1 KCNA7 0 0 73 171 1 1
RYR1 FKBP1C 0 0 108 756 1 1
RYR1 ABCC6 0 0 50 161 1 1
RYR1 KCNJ3 0 0 143 185 1 1
RYR1 VCL 0 0 95 174 1 1
RYR1 ATP13A2 0 0 73 245 1 1
RYR1 RCAN1 0 0 103 279 1 2
RYR1 MUTYH 0 0 232 231 1 1
RYR1 VEZT 0 0 0 201 1 1
RYR1 ATP11B 0 0 0 219 1 1
RYR1 OBSL1 0 0 81 173 1 1
RYR1 ASIC2 0 0 141 199 1 1
RYR1 NFAT5 0 0 0 189 1 1
RYR1 PHKA1 0 0 161 187 1 1
RYR1 XIRP2 0 0 134 464 1 1
RYR1 MYO18B 0 0 265 383 1 1
RYR1 HCN3 0 0 0 267 1 1
RYR1 TAF7L 0 0 70 438 1 1
RYR1 EEF2 0 0 195 280 1 2
RYR1 PAX3 0 0 180 197 1 1
RYR1 TRPM1 0 0 232 238 1 1
RYR1 CACNG5 0 0 108 169 1 1
RYR1 IFT140 0 0 95 151 1 1
RYR1 RBM7 0 0 75 177 1 1
RYR1 CELF1 0 0 324 325 1 1
RYR1 EYA1 0 0 75 176 1 1
RYR1 PLCB1 0 0 165 355 1 1
RYR1 MYF6 0 0 266 317 1 1
RYR1 DMPK 0 0 398 398 1 1
RYR1 EPB41L2 0 0 0 207 1 1
RYR1 SNX33 0 0 0 215 1 1
RYR1 HSPA2 0 720 0 728 1 1
RYR1 AKAP6 270 0 370 735 1 1
RYR1 SMOC1 0 0 123 183 1 1
RYR1 CHRNA1 0 0 394 411 1 1
RYR1 BDNF 0 0 142 152 1 2
RYR1 ANKRD1 0 0 160 252 1 1
RYR1 JPH2 0 360 697 832 1 1
RYR1 KEL 0 0 56 201 1 1
RYR1 MEF2C 0 0 165 215 1 1
RYR1 KCNH5 0 0 0 164 1 1
RYR1 ATP11C 0 0 0 219 1 1
RYR1 ADCY6 0 0 134 191 1 1
RYR1 CATSPERB 0 720 43 738 1 1
RYR1 MTMR1 0 0 537 598 1 1
RYR1 SIRPD 0 0 154 153 1 1
RYR1 CABP1 0 0 123 284 1 1
RYR1 TNNC2 0 0 194 396 1 1
RYR1 UCP3 0 0 207 247 1 1
RYR1 UNC13A 0 0 0 150 1 1
RYR1 KCND2 0 0 77 159 1 1
RYR1 TXN 0 0 138 259 1 1
RYR1 CANX 0 0 247 329 1 2
RYR1 GRIA1 0 0 135 172 1 1
RYR1 HAPLN1 0 0 0 211 1 1
RYR1 CAST 0 0 270 283 1 2
RYR1 S100A10 0 0 103 244 1 1
RYR1 MCUR1 0 0 310 325 1 1
RYR1 KIF14 0 0 151 179 1 1
RYR1 NKX2-5 0 0 308 324 1 1
RYR1 ANK2 0 0 261 306 1 1
RYR1 PLCH1 0 0 47 229 1 1
RYR1 CAT 0 0 180 204 1 2
RYR1 CACNB2 0 720 94 750 1 1
RYR1 MYBPC2 0 0 218 324 1 1
RYR1 COL6A3 0 0 323 339 1 1
RYR1 ATP11A 0 0 0 219 1 1
RYR1 SLCO1B1 0 0 167 167 1 1
RYR1 HSD17B4 0 0 357 357 1 1
RYR1 COL7A1 0 0 150 181 1 1
RYR1 LDLR 0 0 193 211 1 2
RYR1 PPP2R3A 0 0 299 299 1 1
RYR1 ACOT13 0 0 70 282 1 1
RYR1 ATP2A2 0 0 595 820 1 1
RYR1 MYH2 0 0 395 517 1 1
RYR1 OR51A2 0 0 181 181 1 1
RYR1 SLC27A1 0 0 47 303 1 1
RYR1 PLCE1 0 0 0 271 1 1
RYR1 PBDC1 0 0 57 153 1 1
RYR1 CCDC174 0 0 181 329 1 1
RYR1 MICU2 0 0 362 400 1 1
RYR1 SMN2 0 0 184 183 1 1
RYR1 CD38 0 800 82 808 1 2
RYR1 PALLD 0 0 0 243 1 1
RYR1 MDK 0 0 0 171 1 1
RYR1 HPCA 0 0 91 273 1 1
RYR1 SPRY1 0 0 336 424 1 1
RYR1 CHRNG 0 0 382 391 1 1
RYR1 NCF1 0 0 142 161 1 1
RYR1 SMYD1 0 0 96 198 1 1
RYR1 MYL2 0 0 266 391 1 1
RYR1 FAU 0 0 0 165 1 2
RYR1 MYO18A 0 0 82 213 1 1
RYR1 TMX3 0 0 0 153 1 1
RYR1 ATP2B2 0 0 125 432 1 1
RYR1 SNX9 0 0 96 225 1 1
RYR1 MEGF10 0 0 261 324 1 1
RYR1 STIM1 0 0 803 837 1 2
RYR1 ENSG00000257921 0 0 0 188 1 1
RYR1 TXNDC11 0 0 0 153 1 1
RYR1 SORBS1 0 0 75 168 1 1
RYR1 CCND1 0 0 52 223 1 2
RYR1 CACNA1B 0 720 294 869 1 1
RYR1 SARDH 0 0 61 408 1 1
RYR1 LRRC29 0 0 0 152 1 1
RYR1 TMEM38A 0 0 338 373 1 1
RYR1 NOS3 0 0 328 328 1 2
RYR1 RBM24 0 0 83 166 1 1
RYR1 PLAGL2 0 0 63 175 1 1
RYR1 REM1 0 0 210 245 1 1
RYR1 STAC 0 0 342 409 1 1
RYR1 AHR 0 0 134 179 1 2
RYR1 PPP2CA 270 0 0 281 1 1
RYR1 EIF4E 0 0 63 185 1 2
RYR1 EDNRA 0 0 47 152 1 1
RYR1 MYOZ2 0 0 210 260 1 1
RYR1 HSPA9 0 0 448 460 1 1
RYR1 SCN11A 0 0 113 235 1 1
RYR1 KCNA1 0 0 170 267 1 1
RYR1 CAMK2D 0 0 77 226 1 1
RYR1 CIB1 0 0 0 187 1 1
RYR1 TESC 0 0 0 187 1 1
RYR1 PKD1 0 0 360 408 1 1
RYR1 ECH1 0 0 604 604 1 1
RYR1 ABLIM1 0 0 74 174 1 1
RYR1 EFCAB11 0 0 0 187 1 1
RYR1 TXNDC9 0 0 47 180 1 1
RYR1 RASA3 0 0 0 181 1 1
RYR1 PPA2 0 0 180 264 1 1
RYR1 S100A6 0 0 153 175 1 1
RYR1 LSR 0 0 170 169 1 1
RYR1 ZFPM2 0 0 46 170 1 1
RYR1 MCU 0 0 528 572 1 2
RYR1 MB 0 0 340 357 1 2
RYR1 METTL3 270 0 0 270 1 2
RYR1 STAC2 0 0 439 440 1 1
RYR1 NEXN 0 0 309 314 1 1
RYR1 VDAC3 0 0 180 210 1 1
RYR1 SLC2A4 0 0 235 258 1 1
RYR1 SLC24A4 0 0 0 191 1 1
RYR1 TRPV2 0 0 387 400 1 1
RYR1 S100A3 0 0 74 156 1 1
RYR1 SORL1 0 0 0 183 1 1
RYR1 ADAM12 0 0 434 443 1 1
RYR1 SRC 0 0 150 173 1 2
RYR1 ORAI2 0 0 315 433 1 1
RYR1 SARS2 0 0 135 173 1 2
RYR1 APOC1 0 0 295 295 1 1
RYR1 RAG1 0 0 0 208 1 1
RYR1 KCNQ5 0 0 103 162 1 1
RYR1 JPH1 0 360 942 968 1 1
RYR1 VDAC1 0 0 243 248 1 2
RYR1 MC4R 0 0 188 312 1 1
RYR1 PIK3C2A 0 0 397 397 1 1
RYR1 ARHGAP15 0 0 81 184 1 1
RYR1 ABCC12 0 0 0 175 1 1
RYR1 MYBPC1 0 0 243 432 1 1
RYR1 FKBPL 0 0 0 168 1 1
RYR1 SSNA1 0 0 0 189 1 1
RYR1 CYP2D6 0 0 144 202 1 1
RYR1 TRPV4 0 0 233 251 1 1
RYR1 FKBP6 0 0 0 214 1 1
RYR1 UBR1 0 0 0 207 1 1
RYR1 KCNE2 0 0 269 269 1 1
RYR1 APOC2 0 0 389 393 1 1
RYR1 CACNA1A 0 800 306 902 1 1
RYR1 EPB41 0 0 75 214 1 1
RYR1 SORCS1 0 0 0 282 1 1
RYR1 GLRX 0 0 414 414 1 1
RYR1 EFCAB7 0 0 0 187 1 1
RYR1 PDLIM3 109 0 181 264 1 1
RYR1 BIN1 0 0 519 566 1 1
RYR1 ABCC9 0 0 0 185 1 1
RYR1 ADSSL1 0 0 203 236 1 1
RYR1 A1BG 0 0 140 248 1 1
RYR1 TOMM20 0 0 145 155 1 2
RYR1 KCNN2 0 0 166 205 1 1
RYR1 P2RX1 0 0 134 152 1 1
RYR1 CCDC109B 0 0 267 319 1 1
RYR1 INPP5J 0 0 136 192 1 1
RYR1 MRVI1 0 0 0 193 1 1
RYR1 NEURL1B 0 0 0 181 1 1
RYR1 ATP10B 0 0 0 219 1 1
RYR1 CALR3 0 0 0 206 1 1
RYR1 CACNG8 0 720 108 741 1 1
RYR1 MORN4 0 0 0 181 1 1
RYR1 DUOX1 0 0 105 152 1 1
RYR1 PHKG1 0 0 247 378 1 1
RYR1 LRP4 0 0 63 206 1 1
RYR1 COL6A1 0 0 299 307 1 1
RYR1 LETM1 0 0 455 506 1 1
RYR1 SLC26A6 0 0 66 157 1 1
RYR1 SCN5A 0 0 464 582 1 1
RYR1 NOX4 0 0 492 539 1 2
RYR1 TTPAL 0 0 134 152 1 1
RYR1 SLN 0 0 518 547 1 1
RYR1 CYP2A7 0 0 431 431 1 1
RYR1 MTMR4 0 0 51 221 1 1
RYR1 KMT2D 0 0 174 315 1 1
RYR1 ATP13A3 0 0 0 219 1 1
RYR1 DYSF 0 0 505 534 1 1
RYR1 PPP1R9B 0 0 261 261 1 1
RYR1 CAPN1 0 0 181 203 1 2
RYR1 PTP4A3 0 0 91 182 1 1
RYR1 ATP10D 0 0 0 219 1 1
RYR1 AKT1 0 0 246 269 1 2
RYR1 CACNA2D1 0 720 621 905 1 1
RYR1 GRIK1 0 0 306 321 1 1
RYR1 FBN2 0 0 123 238 1 1
RYR1 MTMR14 0 0 505 513 1 2
RYR1 DUSP23 0 0 0 193 1 1
RYR1 FKRP 0 0 379 379 1 1
RYR1 DHRS7C 0 0 150 360 1 1
RYR1 PRDM16 0 0 95 160 1 1
RYR1 SYNE2 0 0 167 284 1 1
RYR1 GNAL 0 0 75 199 1 1
RYR1 SCN9A 0 0 0 252 1 1
RYR1 PRKCG 0 0 398 433 1 1
RYR1 ATP2A3 0 0 456 758 1 1
RYR1 PDE4B 0 540 0 611 1 1
RYR1 TMEM5 0 0 150 200 1 1
RYR1 SCGN 0 0 0 187 1 1
RYR1 TPM3 0 0 465 537 1 1
RYR1 PKD2 0 0 388 470 1 2
RYR1 PDPR 0 0 73 155 1 1
RYR1 FBN1 0 0 143 181 1 1
RYR1 EFCAB13 0 0 0 187 1 1
RYR1 GUCA1B 0 0 0 187 1 1
RYR1 GJA5 0 0 386 386 1 1
RYR1 ZNF525 0 0 155 169 1 1
RYR1 PLEKHF1 0 0 72 165 1 1
RYR1 NID1 0 0 304 338 1 1
RYR1 PDE5A 0 0 107 181 1 1
RYR1 EMD 0 0 242 247 1 1
RYR1 ID2 0 0 358 358 1 1
RYR1 KCNJ2 0 0 229 245 1 1
RYR1 GUCA1A 0 0 0 187 1 1
RYR1 GJA1 0 0 357 357 1 1
RYR1 CSMD3 0 0 211 216 1 1
RYR1 TCAP 0 0 268 311 1 1
RYR1 SYPL2 0 0 603 636 1 1
RYR1 PPP3CA 0 0 235 269 1 1
RYR1 MYH4 0 0 370 611 1 1
RYR1 OTOF 0 0 142 193 1 1
RYR1 MAG 0 0 0 170 1 1
RYR1 NFATC4 0 0 163 234 1 1
RYR1 GRM5 0 0 102 169 1 1
RYR1 C1orf101 0 720 71 732 1 1
RYR1 MYO1A 0 0 0 161 1 1
RYR1 ANK3 0 0 124 208 1 1
RYR1 AKAP7 0 0 167 191 1 1
RYR1 USH2A 0 0 142 194 1 1
RYR1 CETN1 0 0 0 187 1 1
RYR1 RTN4 0 0 61 170 1 1
RYR1 BSCL2 0 0 0 166 1 1
RYR1 SLC24A3 0 0 0 235 1 1
RYR1 KRT18 0 0 305 305 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables ISS
GO:0005262 Molecular Function calcium channel activity enables ISS
GO:0005509 Molecular Function calcium ion binding enables ISS
GO:0048763 Molecular Function calcium-induced calcium release activity enables IBA
GO:0048763 Molecular Function calcium-induced calcium release activity enables IMP
GO:0015278 Molecular Function calcium-release channel activity enables TAS
GO:0005516 Molecular Function calmodulin binding enables ISS
GO:0005219 Molecular Function ryanodine-sensitive calcium-release channel activity enables IBA
GO:0005219 Molecular Function ryanodine-sensitive calcium-release channel activity enables IDA
GO:0005219 Molecular Function ryanodine-sensitive calcium-release channel activity enables IMP
GO:0005219 Molecular Function ryanodine-sensitive calcium-release channel activity enables ISS
GO:0005219 Molecular Function ryanodine-sensitive calcium-release channel activity enables TAS
GO:0005245 Molecular Function voltage-gated calcium channel activity enables ISS
GO:0006816 Biological Process calcium ion transport involved_in ISS
GO:0071313 Biological Process cellular response to caffeine involved_in IMP
GO:0071313 Biological Process cellular response to caffeine involved_in ISS
GO:0071277 Biological Process cellular response to calcium ion involved_in ISS
GO:0006936 Biological Process muscle contraction involved_in ISS
GO:0043931 Biological Process ossification involved in bone maturation involved_in ISS
GO:0003151 Biological Process outflow tract morphogenesis involved_in ISS
GO:0051289 Biological Process protein homotetramerization involved_in ISS
GO:0051480 Biological Process regulation of cytosolic calcium ion concentration involved_in ISS
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IMP
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in ISS
GO:0014808 Biological Process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum involved_in IBA
GO:0014808 Biological Process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum involved_in ISS
GO:0031000 Biological Process response to caffeine involved_in ISS
GO:0001666 Biological Process response to hypoxia involved_in IDA
GO:0048741 Biological Process skeletal muscle fiber development involved_in ISS
GO:0043588 Biological Process skin development involved_in ISS
GO:0006941 Biological Process striated muscle contraction involved_in IBA
GO:0031674 Cellular Component I band located_in IDA
GO:0030018 Cellular Component Z disc is_active_in IBA
GO:0034704 Cellular Component calcium channel complex part_of IBA
GO:0005938 Cellular Component cell cortex located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0070062 Cellular Component extracellular exosome located_in HDA
GO:0014701 Cellular Component junctional sarcoplasmic reticulum membrane located_in TAS
GO:0031090 Cellular Component organelle membrane located_in ISS
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:1990425 Cellular Component ryanodine receptor complex part_of ISS
GO:0042383 Cellular Component sarcolemma is_active_in IBA
GO:0016529 Cellular Component sarcoplasmic reticulum located_in ISS
GO:0033017 Cellular Component sarcoplasmic reticulum membrane is_active_in IBA
GO:0033017 Cellular Component sarcoplasmic reticulum membrane located_in IDA
GO:0033017 Cellular Component sarcoplasmic reticulum membrane located_in ISS
GO:0033017 Cellular Component sarcoplasmic reticulum membrane located_in TAS
GO:0005790 Cellular Component smooth endoplasmic reticulum is_active_in IBA
GO:0014802 Cellular Component terminal cisterna located_in ISS
Pathways
Name DB ID
Stimuli-sensing channels Reactome R-HSA-2672351
Transport of small molecules Reactome R-HSA-382551
Muscle contraction Reactome R-HSA-397014
Cardiac conduction Reactome R-HSA-5576891
Ion homeostasis Reactome R-HSA-5578775
Ion channel transport Reactome R-HSA-983712
Cell-type dependent selectivity of CCK2R signaling (WP3679) WikiPathways WP3679_r117678
Airway smooth muscle cell contraction (WP4962) WikiPathways WP4962_r122013
Myometrial relaxation and contraction pathways (WP289) WikiPathways WP289_r122789
Calcium regulation in cardiac cells (WP536) WikiPathways WP536_r116854
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_000540 3 mRNA transcript variant 1 NC_000019 Reference
XM_011527205 3 mRNA transcript variant X3 NC_000019 Reference
XM_006723317 3 mRNA transcript variant X1 NC_000019 Reference
NM_001042723 2 mRNA transcript variant 2 NC_000019 Reference
XM_006723319 3 mRNA transcript variant X2 NC_000019 Reference
XM_047439202 1 mRNA transcript variant X4 NC_000019 Reference