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NOD2

nucleotide binding oligomerization domain containing 2
General Information
Name nucleotide binding oligomerization domain containing 2
Alias
  • nucleotide-binding oligomerization domain-containing protein 2
  • NLR family, CARD domain containing 2
  • NOD-like receptor C2
  • caspase recruitment domain family, member 15
  • caspase recruitment domain protein 15
  • caspase recruitment domain-containing protein 15
  • inflammatory bowel disease protein 1
  • nucleotide-binding oligomerization domain 2
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
Gene_family Caspase recruitment domain containing|NLR family
organism Homo sapiens
entrez_id 64127
location 16q12.1
transcript_count 18
exon_count 18
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
    Stringdb Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...]
    nextProt Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity (PubMed:12527755). Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling (PubMed:11087742, PubMed:21887730). This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Also plays a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189). Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process (PubMed:33942347).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
NOD2 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
NOD2 BioGRID ZDHHC5 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
NOD2 BioGRID HDGFL3 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID STUB1 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TRIM22 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID IFNL3 GeneID BioGRID Positive Genetic
NOD2 BioGRID IL22 GeneID BioGRID Negative Genetic
NOD2 BioGRID RBL1 GeneID BioGRID Positive Genetic
NOD2 BioGRID E2F4 GeneID BioGRID Negative Genetic
NOD2 BioGRID ATM GeneID BioGRID Negative Genetic
NOD2 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOD2 BioGRID SRPRB GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID ERBIN GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TMED9 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TMED1 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TMED10 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TMED2 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID SPTLC1 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID MYL9 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID VDAC2 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TCP1 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID RPL37A GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID RPL34 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID TWF1 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID PPP2R2A GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID PPP2R1A GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID SLC25A3 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID DNAJA1 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID HADHA GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID ACSL3 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID CLTA GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID BST2 GeneID BioGRID Affinity Capture-MS
NOD2 BioGRID PRKN GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID GOLGA6L5P GeneID BioGRID Two-hybrid
NOD2 BioGRID LURAP1L GeneID BioGRID Two-hybrid
NOD2 BioGRID C10orf67 GeneID BioGRID FRET; Two-hybrid
NOD2 BioGRID CHMP4B GeneID BioGRID Two-hybrid
NOD2 BioGRID IKBIP GeneID BioGRID Two-hybrid
NOD2 BioGRID TRIM41 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
NOD2 BioGRID DOCK7 GeneID BioGRID FRET; Two-hybrid
NOD2 BioGRID SCYL1 GeneID BioGRID Two-hybrid
NOD2 BioGRID ANKHD1 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
NOD2 BioGRID PPP1R12C GeneID BioGRID FRET; Two-hybrid
NOD2 BioGRID WBP11 GeneID BioGRID Two-hybrid
NOD2 BioGRID CHMP5 GeneID BioGRID FRET; Two-hybrid
NOD2 BioGRID PRR16 GeneID BioGRID Two-hybrid
NOD2 BioGRID PPP2R3B GeneID BioGRID FRET; Two-hybrid
NOD2 BioGRID LDOC1 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
NOD2 BioGRID RPL13A GeneID BioGRID Two-hybrid
NOD2 BioGRID ENTR1 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
NOD2 BioGRID PDLIM5 GeneID BioGRID Two-hybrid
NOD2 BioGRID TACC3 GeneID BioGRID Two-hybrid
NOD2 BioGRID TNIP1 GeneID BioGRID Two-hybrid
NOD2 BioGRID HAP1 GeneID BioGRID Two-hybrid
NOD2 BioGRID RIPK2 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
NOD2 BioGRID VIM GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID VCP GeneID BioGRID Two-hybrid
NOD2 BioGRID TPM4 GeneID BioGRID Two-hybrid
NOD2 BioGRID TPM3 GeneID BioGRID Two-hybrid
NOD2 BioGRID TPM1 GeneID BioGRID Two-hybrid
NOD2 BioGRID CCL13 GeneID BioGRID Two-hybrid
NOD2 BioGRID LMNA GeneID BioGRID Two-hybrid
NOD2 BioGRID KRT15 GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID GOLGB1 GeneID BioGRID Two-hybrid
NOD2 BioGRID DCTN1 GeneID BioGRID Two-hybrid
NOD2 BioGRID ANXA2 GeneID BioGRID Two-hybrid
NOD2 BioGRID ALPI GeneID BioGRID Two-hybrid
NOD2 BioGRID RNF31 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID SPATA2 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID CYLD GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID IRGM GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOD2 BioGRID SHARPIN GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID RBCK1 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID TNFAIP3 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID UBC GeneID BioGRID Co-crystal Structure
NOD2 BioGRID NOD1 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID SUGT1 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID NOD2 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOD2 BioGRID XIAP GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOD2 BioGRID TRAF4 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID COPS6 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID CASP12 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID FIS1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID KAT5 GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID TLE1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID TRIM27 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID PPP2R5E GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID GALNT2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
NOD2 BioGRID NAT16 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID BIRC3 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID BIRC2 GeneID BioGRID Affinity Capture-Western
NOD2 Protein ERBIN GeneID HPRD
NOD2 Protein NLRC4 GeneID HPRD
NOD2 Protein RIPK2 GeneID HPRD
NOD2 BioGRID NLRC4 GeneID BioGRID Affinity Capture-Western
NOD2 BioGRID CASP1 GeneID BioGRID Affinity Capture-Western
NOD2 Protein RIPK2 GeneID BIND Nod2 interaction with RICK enhances NF-kappaB activity
NOD2 Protein CASP1 GeneID BIND CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.
NOD2 Protein NLRC4 GeneID BIND CARD12 (CLAN) interacts with CARD15 (Nod2).
StringDB
A B experiments database textmining combined score hadb nhadb
NOD2 CCL8 0 0 180 245 1 1
NOD2 EMR3 0 0 125 158 1 1
NOD2 VIPR1 0 0 184 204 1 1
NOD2 GBP6 0 0 112 150 1 1
NOD2 CHMP5 312 0 0 311 1 1
NOD2 RNASE3 0 0 96 165 1 1
NOD2 GPBAR1 0 0 128 229 1 1
NOD2 CD3E 0 0 112 185 1 1
NOD2 IFNGR1 0 0 266 282 1 1
NOD2 CCL17 0 0 246 279 1 1
NOD2 HLA-B 0 0 233 321 1 1
NOD2 ITGB2 0 0 182 429 1 1
NOD2 LILRB4 0 0 94 179 1 1
NOD2 UEVLD 0 0 0 156 1 1
NOD2 KRAS 0 0 122 154 1 2
NOD2 MNDA 0 0 136 401 1 1
NOD2 IGSF6 0 0 0 170 1 1
NOD2 SOCS3 0 0 500 589 1 1
NOD2 CLEC9A 0 0 181 206 1 1
NOD2 FASLG 0 0 231 250 1 1
NOD2 FOS 0 0 187 187 1 2
NOD2 CCL27 0 0 266 266 1 1
NOD2 S100A8 0 0 220 467 1 2
NOD2 GALNT2 270 0 373 523 1 1
NOD2 RNASE6 0 0 0 298 1 1
NOD2 TIFA 0 0 91 211 1 1
NOD2 SIGIRR 0 0 400 405 1 1
NOD2 IRAK3 0 0 586 623 1 1
NOD2 TNIP1 192 0 242 384 1 1
NOD2 IFNL3 189 0 126 260 1 1
NOD2 FCER1A 0 0 64 176 1 1
NOD2 COPS6 270 0 0 270 1 1
NOD2 ZNRF2 0 0 64 280 1 1
NOD2 IRG1 0 0 204 223 1 1
NOD2 ANGPTL4 0 0 112 167 1 1
NOD2 STAT5A 0 0 181 262 1 1
NOD2 CLDN2 0 0 294 294 1 1
NOD2 PGLYRP3 0 0 390 403 1 1
NOD2 TBKBP1 0 0 181 187 1 1
NOD2 FCN1 0 0 107 264 1 1
NOD2 ENSG00000277117 0 0 242 241 1 1
NOD2 WAS 0 0 139 294 1 1
NOD2 CD86 0 0 420 598 1 1
NOD2 IL18R1 0 0 431 464 1 1
NOD2 HLA-DRA 0 0 212 353 1 1
NOD2 IKBIP 192 0 0 192 1 1
NOD2 NOD1 270 600 941 764 1 2
NOD2 CARD11 0 0 294 342 1 1
NOD2 SHARPIN 675 0 392 799 1 1
NOD2 MADCAM1 0 0 208 217 1 1
NOD2 CFB 0 0 167 167 1 1
NOD2 BIN2 0 0 0 213 1 1
NOD2 NFAM1 0 0 0 196 1 1
NOD2 SNAPIN 0 0 66 166 1 1
NOD2 MUC4 0 0 270 277 1 1
NOD2 TLR6 0 0 608 665 1 1
NOD2 IL2 0 0 460 459 1 1
NOD2 VSIG4 0 0 101 191 1 1
NOD2 ABCB1 0 0 141 171 1 2
NOD2 CCL7 0 0 259 296 1 1
NOD2 BECN1 0 0 587 591 1 2
NOD2 HLA-DPA1 0 0 109 233 1 1
NOD2 TRAF3 0 0 457 478 1 2
NOD2 LRRK2 0 0 664 704 1 2
NOD2 TOLLIP 0 0 406 406 1 1
NOD2 CAD 0 0 445 445 1 2
NOD2 TLR2 0 0 977 985 1 2
NOD2 MAPK11 0 650 71 680 1 1
NOD2 DUSP1 0 0 159 179 1 1
NOD2 PRKCQ 0 0 150 169 1 2
NOD2 ATG12 0 800 455 886 1 2
NOD2 RNASE2 0 0 123 281 1 1
NOD2 CD1B 0 0 180 196 1 1
NOD2 IL13 0 0 468 468 1 2
NOD2 VIL1 0 0 304 304 1 1
NOD2 CTSS 0 0 57 234 1 1
NOD2 ANG 0 0 82 157 1 2
NOD2 ALOX5 0 0 144 310 1 1
NOD2 TNFSF13B 0 0 298 381 1 1
NOD2 CXCL5 0 0 298 339 1 1
NOD2 LYPD8 0 0 120 175 1 1
NOD2 DEFB118 0 0 108 165 1 1
NOD2 FPR3 0 0 167 251 1 1
NOD2 GPR65 0 0 248 335 1 1
NOD2 TRIM22 0 0 234 308 1 1
NOD2 TRIM56 0 0 156 166 1 1
NOD2 RAB20 0 0 84 219 1 1
NOD2 CD5 0 0 127 217 1 1
NOD2 CD28 0 0 295 319 1 1
NOD2 CYBB 0 0 322 502 1 2
NOD2 CD53 0 0 0 282 1 1
NOD2 NLRP3 0 0 838 458 1 2
NOD2 REL 0 0 947 948 1 2
NOD2 ATG101 0 0 170 351 1 2
NOD2 HSPB8 270 0 0 270 1 2
NOD2 CARD16 0 0 170 555 1 1
NOD2 NUF2 0 0 0 165 1 1
NOD2 GNA15 0 0 60 222 1 1
NOD2 CXCL1 0 0 469 506 1 2
NOD2 IL33 0 0 455 455 1 2
NOD2 PSMG1 0 0 181 181 1 1
NOD2 UBE2V1 0 600 170 653 1 1
NOD2 PTGS2 0 0 430 457 1 2
NOD2 NKG7 0 0 0 252 1 1
NOD2 CCL11 0 0 220 237 1 1
NOD2 PSMB9 0 0 120 179 1 1
NOD2 ZNF649 0 0 165 165 1 1
NOD2 AICDA 0 0 150 225 1 1
NOD2 CLEC4M 0 0 122 182 1 1
NOD2 CASP3 0 0 334 344 1 2
NOD2 MASP2 0 0 185 185 1 1
NOD2 PGLYRP1 0 0 523 544 1 1
NOD2 MSR1 0 0 167 198 1 1
NOD2 IL1RL1 0 0 235 235 1 1
NOD2 CEBPB 0 0 141 173 1 2
NOD2 ATG16L1 675 800 989 999 1 2
NOD2 FLOT2 0 0 0 250 1 1
NOD2 RAB2B 0 0 60 156 1 1
NOD2 HCK 0 0 95 370 1 1
NOD2 ECSIT 0 0 109 335 1 1
NOD2 CIITA 0 0 599 376 1 1
NOD2 PRDM1 0 0 242 286 1 1
NOD2 RIPK1 270 0 457 586 1 2
NOD2 CSF1 0 0 294 294 1 1
NOD2 LTBR 0 0 181 181 1 1
NOD2 MRC1 0 0 310 335 1 1
NOD2 ITGAX 0 0 459 534 1 1
NOD2 SLC11A1 0 0 464 548 1 1
NOD2 BLK 0 0 92 286 1 1
NOD2 EPSTI1 0 0 0 162 1 1
NOD2 SOCS2 0 0 157 177 1 1
NOD2 CASP4 270 0 216 502 1 2
NOD2 FGD3 0 0 0 272 1 1
NOD2 CDKN2A 0 0 161 161 1 2
NOD2 CXCL16 0 0 134 176 1 1
NOD2 PIGR 0 0 265 265 1 1
NOD2 CHUK 0 900 466 944 1 1
NOD2 S100A12 0 0 194 433 1 1
NOD2 NLRP11 0 0 323 169 1 1
NOD2 SH2D1A 0 0 181 211 1 1
NOD2 DUSP2 0 0 68 274 1 1
NOD2 SAMHD1 0 0 127 165 1 1
NOD2 CCL3 0 0 379 476 1 1
NOD2 CTSG 0 0 218 256 1 1
NOD2 FCGR3B 0 0 240 363 1 1
NOD2 CCL22 0 0 213 213 1 1
NOD2 C10orf67 312 0 74 335 1 1
NOD2 GPR174 0 0 0 151 1 1
NOD2 HLA-A 0 0 193 235 1 1
NOD2 ICAM3 0 0 283 325 1 1
NOD2 IL18RAP 0 0 450 547 1 1
NOD2 THBD 0 0 143 185 1 1
NOD2 ATM 189 0 96 235 1 2
NOD2 GPR132 0 0 54 170 1 1
NOD2 TRIM32 0 0 90 277 1 1
NOD2 ADPRH 0 0 0 151 1 1
NOD2 MARCO 0 0 245 372 1 1
NOD2 IL23A 0 0 421 451 1 1
NOD2 FLT3 0 0 90 155 1 2
NOD2 PARVG 0 0 0 289 1 1
NOD2 IRAK4 0 0 468 479 1 1
NOD2 CXCL2 0 0 421 459 1 1
NOD2 CCL20 0 0 420 434 1 1
NOD2 HBB 0 0 150 249 1 1
NOD2 IL10 0 0 715 727 1 2
NOD2 GIMAP7 0 0 0 151 1 1
NOD2 CMPK2 0 0 0 190 1 1
NOD2 BTG2 0 0 43 384 1 1
NOD2 IKZF1 0 0 108 249 1 1
NOD2 ACTG1 0 0 141 187 1 1
NOD2 NR1H4 0 0 162 161 1 1
NOD2 TJP1 0 0 270 270 1 1
NOD2 SELE 0 0 213 213 1 1
NOD2 OTUD5 0 0 167 185 1 1
NOD2 TRAT1 0 0 284 341 1 1
NOD2 ATG7 0 0 398 398 1 2
NOD2 NME8 0 0 0 236 1 1
NOD2 CYTIP 0 0 0 273 1 1
NOD2 CASP5 0 0 370 524 1 1
NOD2 WIPI1 0 0 165 165 1 2
NOD2 TRAF7 0 0 151 184 1 1
NOD2 FCER1G 0 0 90 252 1 1
NOD2 CEACAM3 0 0 58 221 1 1
NOD2 NEK7 0 0 193 193 1 1
NOD2 MCEMP1 0 0 0 272 1 1
NOD2 TREML4 0 0 0 181 1 1
NOD2 SALL1 0 0 57 220 1 1
NOD2 STX11 0 0 90 352 1 1
NOD2 GC 0 0 107 171 1 1
NOD2 IRF4 0 0 325 392 1 1
NOD2 FPR1 0 0 211 305 1 1
NOD2 MMEL1 0 0 123 212 1 1
NOD2 NLRP6 0 0 681 374 1 1
NOD2 LTA4H 0 0 293 298 1 1
NOD2 VEGFA 0 0 235 235 1 2
NOD2 BST2 70 0 150 263 1 1
NOD2 GABARAP 0 0 193 210 1 2
NOD2 CD79A 0 0 0 172 1 1
NOD2 FCGR2A 0 0 310 381 1 1
NOD2 CSF3R 0 0 99 204 1 1
NOD2 CLEC4E 0 0 519 563 1 1
NOD2 RORC 0 0 185 185 1 1
NOD2 IL21R 0 0 115 177 1 1
NOD2 KAT5 270 0 0 276 1 1
NOD2 DOCK8 0 0 128 237 1 1
NOD2 MAPK14 0 650 210 739 1 2
NOD2 MC2R 0 0 0 236 1 1
NOD2 SDCCAG3 312 0 306 502 1 1
NOD2 SYK 0 0 394 466 1 2
NOD2 LEP 0 0 211 211 1 1
NOD2 FERMT3 0 0 82 216 1 1
NOD2 NFKBIA 0 0 520 546 1 2
NOD2 ZC3H12A 0 0 113 220 1 1
NOD2 LYN 0 0 161 221 1 1
NOD2 BTNL2 0 0 415 427 1 1
NOD2 IFNB1 0 0 629 644 1 1
NOD2 HMGB1 0 0 341 356 1 2
NOD2 DUOX2 0 0 851 855 1 1
NOD2 IRF5 0 0 632 698 1 1
NOD2 MAP3K5 0 0 123 186 1 1
NOD2 OPTN 0 0 321 329 1 2
NOD2 ACKR2 0 0 268 268 1 1
NOD2 SMAD7 0 0 155 154 1 1
NOD2 PDCD1 0 0 111 202 1 2
NOD2 ITGAM 0 0 459 626 1 1
NOD2 MAP3K4 0 0 170 169 1 1
NOD2 GMIP 0 0 0 151 1 1
NOD2 AIRE 0 0 161 161 1 1
NOD2 IL10RB 0 0 391 406 1 1
NOD2 NKX2-3 0 0 503 503 1 2
NOD2 RNF146 0 0 0 189 1 1
NOD2 SPI1 0 0 293 524 1 1
NOD2 CTSB 0 0 271 295 1 2
NOD2 CST7 0 0 0 231 1 1
NOD2 SLC22A5 0 0 579 579 1 1
NOD2 SASH3 0 0 0 298 1 1
NOD2 C1QA 0 0 63 169 1 1
NOD2 TNFAIP2 0 0 125 230 1 1
NOD2 IRF1 0 0 336 401 1 2
NOD2 ATP4A 0 0 139 157 1 1
NOD2 HLA-C 0 0 293 354 1 1
NOD2 STAT2 0 0 261 286 1 1
NOD2 MUC20 0 0 270 270 1 1
NOD2 CXCR3 0 0 203 302 1 1
NOD2 TSPAN32 0 0 0 151 1 1
NOD2 XBP1 0 0 578 578 1 2
NOD2 TRIP6 0 0 195 226 1 1
NOD2 TLR8 0 0 603 724 1 1
NOD2 C2orf43 0 0 173 173 1 1
NOD2 LGR5 0 0 282 283 1 1
NOD2 LAPTM5 0 0 0 272 1 1
NOD2 CALCOCO2 0 0 459 459 1 2
NOD2 MAP2K6 0 900 134 909 1 1
NOD2 LRPPRC 0 0 0 424 1 2
NOD2 ATG5 0 800 517 901 1 2
NOD2 MVK 0 0 452 452 1 1
NOD2 NFKBIB 0 0 261 270 1 1
NOD2 SERPINB8 0 0 0 182 1 1
NOD2 AQP9 0 0 0 329 1 1
NOD2 SUGT1 270 0 113 440 1 1
NOD2 SLC15A3 270 0 482 675 1 1
NOD2 UBC 653 0 66 668 1 2
NOD2 WDFY4 0 0 0 369 1 1
NOD2 ISG15 0 0 233 276 1 2
NOD2 DEFA4 0 0 161 191 1 1
NOD2 MAP1LC3B 0 0 261 309 1 2
NOD2 RIN3 0 0 0 159 1 1
NOD2 MYO1F 0 0 0 158 1 1
NOD2 KCNN4 0 0 204 251 1 1
NOD2 VAV1 0 0 74 169 1 1
NOD2 TIFAB 0 0 0 188 1 1
NOD2 NCF2 0 0 209 457 1 1
NOD2 ENSG00000255819 0 0 160 197 1 1
NOD2 CEACAM4 0 0 0 299 1 1
NOD2 IL22RA1 0 0 181 181 1 1
NOD2 GBP3 0 0 100 156 1 1
NOD2 ATG10 0 0 202 202 1 2
NOD2 CORT 0 0 306 306 1 1
NOD2 HLA-F 0 0 74 171 1 1
NOD2 CXCR5 0 0 122 607 1 1
NOD2 DEDD2 0 0 112 468 1 1
NOD2 C3 0 0 235 235 1 2
NOD2 FN1 0 0 216 216 1 2
NOD2 PGLYRP4 0 0 358 377 1 1
NOD2 PILRA 0 0 0 177 1 1
NOD2 CCR7 0 0 236 353 1 1
NOD2 IKBKG 270 900 566 966 1 1
NOD2 RAG2 0 0 204 204 1 1
NOD2 CCR9 0 0 253 275 1 1
NOD2 CD300LB 0 0 0 358 1 1
NOD2 RIPK4 0 0 168 167 1 1
NOD2 TBX21 0 0 335 454 1 1
NOD2 ULK1 0 0 306 306 1 2
NOD2 LILRB3 0 0 74 241 1 1
NOD2 ELANE 0 0 181 210 1 1
NOD2 PRKCA 0 0 103 271 1 1
NOD2 DRAM1 0 0 167 182 1 2
NOD2 S100A9 0 0 96 370 1 1
NOD2 RELB 0 0 289 334 1 2
NOD2 CXCL3 0 0 261 309 1 1
NOD2 NAT9 0 0 160 159 1 1
NOD2 RAB7A 0 0 217 234 1 2
NOD2 TXNIP 0 0 194 216 1 2
NOD2 TYMP 0 0 42 211 1 1
NOD2 RUFY4 0 0 93 322 1 1
NOD2 TNFSF14 0 0 128 166 1 1
NOD2 MMP8 0 0 140 166 1 1
NOD2 BCL2A1 0 0 137 369 1 1
NOD2 FNBP1L 0 0 143 196 1 1
NOD2 IFI16 0 0 418 435 1 1
NOD2 ENSG00000272980 0 0 392 410 1 1
NOD2 IFNAR1 0 0 416 437 1 1
NOD2 IL5 0 0 417 416 1 1
NOD2 IL1R2 0 0 253 386 1 1
NOD2 ATP12A 0 0 140 158 1 1
NOD2 CMKLR1 0 0 92 192 1 1
NOD2 GCG 0 0 102 195 1 1
NOD2 TNFAIP3 270 900 460 961 1 2
NOD2 NFKB2 0 0 283 365 1 1
NOD2 ERAP2 0 0 181 181 1 1
NOD2 ATG4B 0 0 231 247 1 2
NOD2 APOL1 0 0 91 216 1 2
NOD2 CSF1R 0 0 142 252 1 1
NOD2 DEFB4A 0 0 599 599 1 1
NOD2 WDFY3 0 0 119 172 1 2
NOD2 UVRAG 0 0 210 210 1 2
NOD2 AGK 0 0 0 181 1 1
NOD2 IRF7 0 0 503 559 1 1
NOD2 SLAMF8 0 0 0 169 1 1
NOD2 SOCS1 0 0 325 368 1 1
NOD2 BTK 0 0 156 371 1 1
NOD2 ARHGAP9 0 0 0 167 1 1
NOD2 IFNL1 0 0 150 167 1 1
NOD2 FFAR3 0 0 233 309 1 1
NOD2 MS4A14 0 0 0 284 1 1
NOD2 KLRC4 0 0 235 235 1 1
NOD2 ATF3 0 0 162 161 1 2
NOD2 CD6 0 0 119 169 1 1
NOD2 GBP5 0 0 286 490 1 1
NOD2 RETN 0 0 122 260 1 1
NOD2 CD44 0 0 193 216 1 2
NOD2 IL7 0 0 246 264 1 1
NOD2 PDLIM5 192 0 0 206 1 1
NOD2 IL1RN 0 0 421 596 1 1
NOD2 MMP3 0 0 157 156 1 1
NOD2 LPIN2 0 0 392 392 1 1
NOD2 CASP2 0 0 181 193 1 1
NOD2 VDR 0 0 412 439 1 2
NOD2 SIRPD 0 0 0 214 1 1
NOD2 NBR1 0 0 294 294 1 2
NOD2 LCT 0 0 184 183 1 1
NOD2 TNF 0 0 710 778 1 2
NOD2 PLA2G2A 0 0 253 252 1 1
NOD2 TANK 0 0 286 286 1 2
NOD2 TIRAP 0 0 517 517 1 1
NOD2 HLA-DMA 0 0 82 178 1 1
NOD2 C11orf30 0 0 171 222 1 1
NOD2 RNF135 0 0 213 222 1 1
NOD2 TBC1D10C 0 0 0 169 1 1
NOD2 IL23R 0 0 781 785 1 1
NOD2 FUT7 0 0 0 231 1 1
NOD2 ITCH 0 900 322 929 1 1
NOD2 ADCY7 0 0 113 259 1 1
NOD2 NAIP 0 0 602 622 1 1
NOD2 TRAF3IP3 0 0 134 339 1 1
NOD2 MS4A6A 0 0 0 152 1 1
NOD2 IFI30 0 0 74 188 1 1
NOD2 MMP7 0 0 241 240 1 1
NOD2 CD300LF 0 0 52 342 1 1
NOD2 FIS1 270 0 44 272 1 2
NOD2 CD209 0 0 459 496 1 1
NOD2 WIPI2 0 0 194 194 1 2
NOD2 CLEC10A 0 0 90 260 1 1
NOD2 RNASEL 0 0 325 325 1 1
NOD2 FCAR 0 0 150 171 1 1
NOD2 HPRT1 0 0 181 181 1 1
NOD2 GPR35 0 0 243 249 1 1
NOD2 IFI44 0 0 113 377 1 1
NOD2 PPP2R5E 270 0 78 298 1 1
NOD2 PTPN2 0 0 465 477 1 2
NOD2 TECPR1 0 0 227 226 1 1
NOD2 CARD18 0 0 341 372 1 1
NOD2 CCL19 0 0 180 220 1 1
NOD2 APOBR 0 0 0 299 1 1
NOD2 CHIT1 0 0 144 177 1 1
NOD2 MUC13 0 0 276 276 1 1
NOD2 CTLA4 0 0 420 452 1 2
NOD2 ARHGAP25 0 0 0 155 1 1
NOD2 MARCH1 0 0 96 170 1 1
NOD2 PTK2B 0 0 81 154 1 1
NOD2 CAT 0 0 175 193 1 2
NOD2 GFI1 0 0 75 154 1 1
NOD2 ATG2A 0 0 183 230 1 2
NOD2 LCP1 0 0 0 246 1 1
NOD2 C7orf72 0 0 112 150 1 1
NOD2 NDUFA13 270 0 701 772 1 1
NOD2 DEFA1 0 0 156 197 1 1
NOD2 RETNLB 0 0 213 213 1 1
NOD2 FSTL1 0 0 362 362 1 1
NOD2 TRAF3IP2 0 0 159 158 1 1
NOD2 SFTPD 0 0 180 179 1 1
NOD2 P2RY10 0 0 0 204 1 1
NOD2 CYP24A1 0 0 163 169 1 1
NOD2 PROK2 0 0 0 151 1 1
NOD2 SNX20 0 0 427 526 1 1
NOD2 DEF6 0 0 0 181 1 1
NOD2 DDX60 0 0 172 242 1 1
NOD2 HBD 0 0 153 205 1 1
NOD2 ADRB2 0 0 103 154 1 1
NOD2 FCGR1A 0 0 240 363 1 1
NOD2 AHR 0 0 279 279 1 2
NOD2 SLPI 0 0 182 201 1 1
NOD2 CHMP4B 192 0 0 192 1 2
NOD2 NLRP2 0 0 402 258 1 1
NOD2 CSF2RB 0 0 181 454 1 1
NOD2 CD274 0 0 243 296 1 2
NOD2 TIMD4 0 0 127 171 1 1
NOD2 RAB44 0 0 0 181 1 1
NOD2 ARHGEF7 0 0 471 482 1 1
NOD2 FAM192A 0 0 74 237 1 1
NOD2 TACC3 192 0 0 192 1 1
NOD2 HLA-E 0 0 81 174 1 1
NOD2 DEFA1B 0 0 161 191 1 1
NOD2 ANXA2 192 0 49 198 1 1
NOD2 NCF1 0 0 210 352 1 1
NOD2 BLNK 0 0 47 203 1 1
NOD2 IRAK2 0 600 315 714 1 1
NOD2 VNN2 0 0 0 215 1 1
NOD2 DENND1B 0 0 171 171 1 1
NOD2 PTAFR 0 0 150 270 1 1
NOD2 FIBCD1 0 0 202 268 1 1
NOD2 IFIT2 0 0 158 188 1 1
NOD2 RNF186 0 0 323 331 1 1
NOD2 HK3 0 0 44 348 1 1
NOD2 CD19 0 0 251 305 1 1
NOD2 SAMD9L 0 0 0 156 1 1
NOD2 IRF8 0 0 243 447 1 1
NOD2 HP 0 0 210 210 1 1
NOD2 SRC 0 0 209 209 1 2
NOD2 GRAP 0 0 0 157 1 1
NOD2 DOCK2 0 0 122 235 1 1
NOD2 RAG1 0 0 261 261 1 1
NOD2 CDC42 0 0 169 169 1 2
NOD2 TNFSF11 0 0 263 279 1 2
NOD2 IL25 0 0 181 181 1 1
NOD2 BPI 0 0 170 200 1 1
NOD2 IL26 0 0 242 241 1 1
NOD2 IL36B 0 0 112 209 1 1
NOD2 APOE 0 0 185 185 1 2
NOD2 BBOX1 0 0 286 286 1 1
NOD2 TREML1 0 0 0 151 1 1
NOD2 CCR8 0 0 94 160 1 1
NOD2 NAT16 270 0 0 270 1 1
NOD2 EIF2AK3 0 0 167 175 1 2
NOD2 HNF4A 0 0 202 202 1 1
NOD2 RNASE7 0 0 158 157 1 1
NOD2 STAT6 0 0 262 297 1 1
NOD2 ATG3 0 0 260 270 1 2
NOD2 LGALS3 0 0 204 204 1 2
NOD2 MIF 0 0 144 162 1 2
NOD2 FRMPD2 0 0 747 750 1 1
NOD2 TLR3 0 0 682 710 1 2
NOD2 ANKRD17 161 0 67 198 1 1
NOD2 METTL6 0 0 62 238 1 1
NOD2 IL19 0 0 257 256 1 1
NOD2 CORO1A 0 0 68 208 1 1
NOD2 RSAD2 0 0 193 255 1 1
NOD2 TNFRSF18 0 0 140 208 1 1
NOD2 CD180 0 0 134 185 1 1
NOD2 RGS18 0 0 48 215 1 1
NOD2 CD52 0 0 57 296 1 1
NOD2 RAC2 0 0 155 252 1 1
NOD2 P2RX1 0 0 0 231 1 1
NOD2 KLRB1 0 0 123 177 1 1
NOD2 GIMAP2 0 0 150 200 1 1
NOD2 STXBP2 0 0 85 158 1 1
NOD2 IL4I1 0 0 74 204 1 1
NOD2 JAK1 0 0 241 240 1 2
NOD2 ICOS 0 0 74 162 1 1
NOD2 NWD1 0 0 141 519 1 1
NOD2 FOXP3 0 0 469 488 1 2
NOD2 HMOX1 0 0 148 179 1 2
NOD2 IL32 0 0 582 594 1 1
NOD2 PTPN6 0 0 81 255 1 1
NOD2 HLA-DOB 0 0 67 210 1 1
NOD2 TBK1 0 0 726 728 1 2
NOD2 PPBP 0 0 74 197 1 1
NOD2 TICAM2 0 0 166 268 1 1
NOD2 CCDC88B 0 0 119 192 1 1
NOD2 CLEC5A 0 0 212 330 1 1
NOD2 LDOC1 312 0 81 340 1 1
NOD2 RIPK3 0 0 321 448 1 2
NOD2 ADCY4 0 0 0 171 1 1
NOD2 IFIT1 0 0 231 237 1 1
NOD2 REG3A 0 0 329 370 1 1
NOD2 CD2 0 0 90 225 1 1
NOD2 HAP1 192 0 0 192 1 1
NOD2 PRKCD 0 0 155 223 1 2
NOD2 C1QB 0 0 81 155 1 1
NOD2 PPP2R3B 312 0 0 327 1 1
NOD2 CDKAL1 0 0 181 198 1 1
NOD2 TRIM50 192 0 45 253 1 1
NOD2 RASSF5 0 0 0 155 1 1
NOD2 HCAR3 0 0 0 333 1 1
NOD2 TGFB1 0 0 141 194 1 2
NOD2 STAT5B 0 0 185 195 1 1
NOD2 RAB7B 0 0 213 231 1 1
NOD2 FAS 0 0 147 171 1 2
NOD2 CARD14 0 0 432 444 1 1
NOD2 F13A1 0 0 0 165 1 1
NOD2 OR5V1 0 0 123 192 1 1
NOD2 CARD8 0 0 653 671 1 1
NOD2 VCAM1 0 0 235 262 1 1
NOD2 GARS 0 0 0 193 1 1
NOD2 MBTPS1 0 0 46 164 1 1
NOD2 CD4 0 0 603 657 1 2
NOD2 INPP5D 0 0 90 193 1 1
NOD2 PPARG 0 0 293 293 1 2
NOD2 AKT1 0 0 325 325 1 2
NOD2 CYTH4 0 0 0 195 1 1
NOD2 GBP2 0 0 181 319 1 1
NOD2 AAMP 0 800 509 903 1 1
NOD2 SP140 0 0 95 212 1 1
NOD2 IL17C 0 0 241 256 1 1
NOD2 CD48 0 0 74 311 1 1
NOD2 WBP11 192 0 52 235 1 1
NOD2 IL12RB1 0 0 307 327 1 1
NOD2 CSF2 0 0 504 514 1 1
NOD2 LY96 0 0 508 544 1 1
NOD2 E2F4 189 0 0 206 1 1
NOD2 CFH 0 0 170 188 1 1
NOD2 XIAP 675 0 757 917 1 2
NOD2 PPP2R4 0 0 448 448 1 1
NOD2 DEFA3 0 0 125 167 1 1
NOD2 CD247 0 0 107 180 1 1
NOD2 RPLP2 0 0 0 204 1 1
NOD2 APOL3 0 0 0 241 1 1
NOD2 DEFB135 0 0 123 299 1 1
NOD2 PANX1 0 0 321 321 1 1
NOD2 DUOX1 0 0 206 427 1 1
NOD2 ENSG00000279392 0 0 166 184 1 1
NOD2 ATF6 0 0 413 413 1 2
NOD2 ALOX5AP 0 0 66 232 1 1
NOD2 IKBKB 0 900 459 943 1 2
NOD2 NLRC4 486 0 886 748 1 2
NOD2 HSP90AB1 0 0 71 302 1 2
NOD2 DDX56 0 0 158 157 1 1
NOD2 MALT1 0 0 325 340 1 1
NOD2 USP25 0 0 156 155 1 1
NOD2 CXCL10 0 0 456 518 1 2
NOD2 CYLD 394 900 459 965 1 1
NOD2 PHF20 0 0 173 173 1 1
NOD2 IL11 0 0 185 185 1 1
NOD2 IFNGR2 0 0 193 213 1 1
NOD2 IL24 0 0 95 168 1 2
NOD2 IRF3 0 0 603 603 1 2
NOD2 CD34 0 0 161 161 1 2
NOD2 ARG2 0 0 161 161 1 1
NOD2 CCL3L3 0 0 90 191 1 1
NOD2 APOL4 0 0 61 159 1 1
NOD2 NLRP7 0 0 518 299 1 1
NOD2 MAP3K1 0 0 113 213 1 1
NOD2 PYCARD 0 0 602 636 1 2
NOD2 MTURN 0 0 71 192 1 1
NOD2 ENTPD3 0 0 46 224 1 1
NOD2 TNFSF8 0 0 233 369 1 1
NOD2 CARD6 0 0 341 354 1 1
NOD2 TPM3 192 0 0 192 1 1
NOD2 CFP 0 0 95 212 1 1
NOD2 CD1D 0 0 282 356 1 1
NOD2 GPR183 0 0 47 196 1 1
NOD2 CLEC12B 0 0 97 204 1 1
NOD2 PIK3R6 0 0 0 299 1 1
NOD2 TLR9 0 0 828 861 1 2
NOD2 FKBP14 0 0 43 234 1 1
NOD2 CD8A 0 0 520 550 1 1
NOD2 ADAM8 0 0 0 282 1 1
NOD2 SIGLEC7 0 0 0 279 1 1
NOD2 DEFA6 0 0 408 408 1 1
NOD2 MAST3 0 0 211 229 1 1
NOD2 PSMB8 0 0 253 289 1 1
NOD2 OSCAR 0 0 43 201 1 1
NOD2 ARHGEF2 0 0 460 460 1 1
NOD2 LSP1 0 0 95 254 1 1
NOD2 CCDC122 0 0 595 595 1 1
NOD2 HAVCR2 0 0 81 156 1 1
NOD2 RUNX3 0 0 73 165 1 1
NOD2 TNFRSF13C 0 0 150 168 1 1
NOD2 SLAMF1 0 0 113 273 1 1
NOD2 TNFSF4 0 0 270 270 1 1
NOD2 IL22RA2 0 0 195 195 1 1
NOD2 RIPK2 879 900 989 999 1 2
NOD2 LCK 0 0 125 150 1 1
NOD2 VCP 192 0 44 209 1 2
NOD2 CCRL2 0 0 386 449 1 1
NOD2 IL17RA 0 0 340 372 1 1
NOD2 ACAP1 0 0 334 377 1 1
NOD2 CLEC6A 0 0 501 566 1 1
NOD2 PELI3 0 0 170 230 1 1
NOD2 TICAM1 0 0 413 446 1 2
NOD2 NFKBIE 0 0 182 236 1 1
NOD2 ASCL2 0 0 46 156 1 1
NOD2 ERN2 0 0 216 216 1 1
NOD2 TMC8 0 0 0 170 1 1
NOD2 GPATCH3 0 0 72 232 1 1
NOD2 IL36RN 0 0 219 219 1 1
NOD2 CSTA 0 0 50 281 1 1
NOD2 KRT15 270 0 0 285 1 1
NOD2 IL7R 0 0 232 283 1 1
NOD2 IL37 0 0 160 217 1 1
NOD2 ANKHD1 312 0 45 327 1 1
NOD2 CCR5 0 0 322 481 1 1
NOD2 CD69 0 0 193 278 1 1
NOD2 LAMB1 0 0 267 295 1 1
NOD2 LTA 0 0 274 498 1 1
NOD2 NLRP13 0 0 320 165 1 1
NOD2 S1PR4 0 0 0 221 1 1
NOD2 C1orf162 0 0 0 187 1 1
NOD2 SIGLEC1 0 0 76 239 1 1
NOD2 MAPK12 0 650 74 666 1 1
NOD2 SERPINA1 0 0 156 239 1 2
NOD2 ENSG00000173366 0 0 710 747 1 1
NOD2 SERPINB2 0 0 120 236 1 1
NOD2 ITGAL 0 0 116 241 1 1
NOD2 IL10RA 0 0 470 631 1 1
NOD2 HNRNPA1 0 0 684 700 1 1
NOD2 DAPP1 0 0 0 214 1 1
NOD2 FZD1 0 0 0 210 1 1
NOD2 TYK2 0 0 370 385 1 1
NOD2 FUT2 0 0 517 520 1 1
NOD2 GOLGB1 192 0 0 192 1 1
NOD2 TMEM173 0 0 342 361 1 1
NOD2 BATF 0 0 81 245 1 1
NOD2 TFF3 0 0 180 179 1 1
NOD2 JUN 0 0 526 526 1 2
NOD2 ARID5A 0 0 74 155 1 1
NOD2 CASP1 486 0 964 990 1 2
NOD2 CCR3 0 0 163 212 1 1
NOD2 EVI2B 0 0 0 213 1 1
NOD2 CD74 0 0 74 184 1 1
NOD2 CD27 0 0 119 162 1 1
NOD2 TOX3 0 0 0 195 1 1
NOD2 TRIM38 0 0 124 166 1 1
NOD2 SNCA 0 0 167 167 1 2
NOD2 CXCL6 0 0 107 155 1 1
NOD2 FFAR2 0 0 337 357 1 1
NOD2 MAP2K3 0 900 96 908 1 1
NOD2 PADI4 0 0 193 222 1 1
NOD2 JAK3 0 0 120 194 1 1
NOD2 PIK3CG 0 0 81 162 1 1
NOD2 HLA-DRB1 0 0 310 425 1 1
NOD2 CEACAM6 0 0 286 286 1 1
NOD2 GSTA4 0 0 0 190 1 1
NOD2 TNFSF10 0 0 208 295 1 2
NOD2 ORMDL3 0 0 393 394 1 2
NOD2 AIF1 0 0 95 241 1 2
NOD2 SPRYD7 0 0 386 386 1 1
NOD2 ATG13 0 0 214 292 1 2
NOD2 INS 0 0 282 282 1 2
NOD2 SELP 0 0 142 204 1 1
NOD2 ACTB 0 0 392 416 1 2
NOD2 ITGB7 0 0 113 198 1 1
NOD2 CD40 0 0 467 507 1 2
NOD2 NLRX1 0 0 668 381 1 2
NOD2 FPR2 0 0 261 346 1 1
NOD2 THEMIS2 0 0 0 221 1 1
NOD2 TLE1 270 0 56 281 1 1
NOD2 GBP7 0 0 120 158 1 1
NOD2 SELL 0 0 234 408 1 1
NOD2 ARL2BP 0 0 57 246 1 1
NOD2 HLA-DMB 0 0 0 181 1 1
NOD2 MMP9 0 0 261 364 1 2
NOD2 B2M 0 0 172 253 1 1
NOD2 MAPK3 0 0 254 264 1 2
NOD2 SQSTM1 281 0 293 469 1 2
NOD2 MFNG 0 0 0 158 1 1
NOD2 FCGR2B 0 0 213 354 1 1
NOD2 GIMAP4 0 0 134 247 1 1
NOD2 LBP 0 0 246 245 1 1
NOD2 HSP90AA1 0 0 825 850 1 2
NOD2 IL3 0 0 184 183 1 1
NOD2 LTB 0 0 123 240 1 1
NOD2 BCL3 0 0 73 195 1 1
NOD2 SLC9A3 0 0 103 164 1 1
NOD2 MBL2 0 0 401 400 1 1
NOD2 IL21 0 0 0 207 1 1
NOD2 CEBPA 0 0 99 178 1 1
NOD2 CRP 0 0 407 407 1 2
NOD2 MYO1G 0 0 0 175 1 1
NOD2 CLEC16A 0 0 185 202 1 2
NOD2 BCL10 0 0 675 675 1 1
NOD2 SEMA4A 0 0 0 214 1 1
NOD2 MLKL 0 0 194 229 1 2
NOD2 PACRG 0 0 322 351 1 1
NOD2 FYB 0 0 0 215 1 1
NOD2 NLRP9 0 0 325 167 1 1
NOD2 CXCR1 0 0 226 341 1 1
NOD2 TRIM31 0 0 130 198 1 1
NOD2 RSPRY1 0 0 91 279 1 1
NOD2 PTPRC 0 0 323 450 1 1
NOD2 GPR84 0 0 86 312 1 1
NOD2 MS4A1 0 0 0 179 1 1
NOD2 IL22 189 0 391 484 1 1
NOD2 GABARAPL1 0 0 282 297 1 2
NOD2 SLC15A2 0 0 278 278 1 1
NOD2 UNC93B1 0 0 229 333 1 1
NOD2 DEFB124 0 0 103 258 1 1
NOD2 ZMYND15 0 0 0 181 1 1
NOD2 ICAM1 0 0 392 421 1 2
NOD2 RALB 0 0 123 177 1 2
NOD2 ATG9A 0 0 125 200 1 2
NOD2 TNFRSF14 0 0 112 204 1 1
NOD2 CSF2RA 0 0 108 188 1 1
NOD2 ZPBP2 0 0 171 180 1 1
NOD2 FGL2 0 0 45 166 1 1
NOD2 IFNAR2 0 0 165 195 1 1
NOD2 RHOA 0 0 162 161 1 2
NOD2 BID 0 0 623 623 1 2
NOD2 UBE2L3 0 0 166 184 1 1
NOD2 CD1C 0 0 210 314 1 1
NOD2 KLRK1 0 0 165 174 1 1
NOD2 CCNY 0 0 296 311 1 1
NOD2 CD3D 0 0 96 160 1 1
NOD2 PLA2G1B 0 0 181 181 1 1
NOD2 TPM1 192 0 0 192 1 1
NOD2 SLC15A1 0 0 456 462 1 1
NOD2 CRLF2 0 0 189 189 1 1
NOD2 TLR5 0 0 830 846 1 1
NOD2 GNA12 0 0 208 223 1 1
NOD2 CXCL12 0 0 166 165 1 2
NOD2 GPR29 0 0 392 392 1 1
NOD2 UBE2N 0 600 233 683 1 1
NOD2 DDX41 0 0 323 337 1 1
NOD2 AIM2 0 0 637 667 1 2
NOD2 DDX58 0 0 807 816 1 1
NOD2 PYDC2 0 0 236 236 1 1
NOD2 PLA2G10 0 0 181 181 1 1
NOD2 AGER 0 0 203 242 1 2
NOD2 CD33 0 0 96 153 1 1
NOD2 MB21D1 0 0 451 451 1 1
NOD2 EFCAB1 0 0 76 237 1 1
NOD2 CDH1 0 0 271 271 1 2
NOD2 DEFB4B 0 0 460 459 1 1
NOD2 NCF4 0 0 325 527 1 1
NOD2 TMEM201 0 0 395 456 1 1
NOD2 TPM4 192 0 0 192 1 1
NOD2 FAM92B 0 0 306 306 1 1
NOD2 AMICA1 0 0 95 188 1 1
NOD2 TRIM21 0 0 155 261 1 1
NOD2 MAF 0 0 257 256 1 1
NOD2 ZNF365 0 0 341 341 1 1
NOD2 ATG16L2 0 0 310 343 1 2
NOD2 RNF31 686 0 403 804 1 1
NOD2 BSG 0 0 843 843 1 1
NOD2 PIK3R5 0 0 0 335 1 1
NOD2 FAM26F 0 0 0 159 1 1
NOD2 TRADD 0 0 290 341 1 1
NOD2 PIK3AP1 0 0 0 167 1 1
NOD2 DCTN1 192 0 0 192 1 1
NOD2 SIGLEC9 0 0 57 288 1 1
NOD2 SRGN 0 0 56 176 1 1
NOD2 MAVS 0 800 988 997 1 2
NOD2 GBP1 0 0 163 246 1 1
NOD2 CCL4 0 0 321 456 1 1
NOD2 CEACAM1 0 0 119 159 1 1
NOD2 MAP1LC3C 0 0 141 159 1 2
NOD2 IL1A 0 0 517 537 1 1
NOD2 ALB 0 0 315 333 1 2
NOD2 CD68 0 0 260 308 1 2
NOD2 CASP8 0 0 390 430 1 2
NOD2 LRRFIP1 0 0 262 284 1 1
NOD2 CCL2 0 0 518 530 1 2
NOD2 GYPC 0 0 134 155 1 1
NOD2 OTULIN 0 0 427 426 1 1
NOD2 CD276 0 0 293 298 1 1
NOD2 IDO1 0 0 210 249 1 1
NOD2 CARD17 0 0 288 598 1 1
NOD2 GPSM1 0 0 291 290 1 1
NOD2 IL16 0 0 123 207 1 1
NOD2 TYROBP 0 0 172 423 1 1
NOD2 CASP7 0 0 173 185 1 1
NOD2 PHF11 0 0 158 201 1 1
NOD2 TRIM41 312 0 103 364 1 1
NOD2 IL17RE 0 0 300 300 1 1
NOD2 TNFAIP8L2 0 0 445 543 1 1
NOD2 ITLN1 0 0 250 250 1 1
NOD2 AOAH 0 0 90 260 1 1
NOD2 IL9 0 0 241 240 1 1
NOD2 IL27 0 0 96 222 1 1
NOD2 IL4 0 0 509 509 1 1
NOD2 SIRPA 0 0 153 184 1 1
NOD2 LGALS8 0 0 241 240 1 1
NOD2 IL17REL 0 0 302 302 1 1
NOD2 IFI44L 0 0 49 174 1 1
NOD2 ZMIZ1 0 0 167 185 1 1
NOD2 MYLK 0 0 194 236 1 1
NOD2 SERPINB1 0 0 0 151 1 1
NOD2 SLC46A2 0 0 132 220 1 1
NOD2 IL17F 0 0 401 400 1 1
NOD2 BIRC3 270 900 410 960 1 1
NOD2 SMAD3 0 0 206 206 1 2
NOD2 DUSP12 0 0 108 175 1 1
NOD2 CYCS 0 0 163 194 1 2
NOD2 TLR7 0 0 694 723 1 2
NOD2 DHX36 0 0 234 252 1 1
NOD2 MAPK9 0 0 143 161 1 2
NOD2 NWD2 0 0 75 255 1 1
NOD2 CXCL11 0 0 229 284 1 1
NOD2 PYHIN1 0 0 167 191 1 1
NOD2 ATG4A 0 0 167 199 1 2
NOD2 CASP9 0 0 244 255 1 2
NOD2 IL18BP 0 0 145 166 1 1
NOD2 TRAF6 270 600 602 880 1 2
NOD2 PELI1 0 0 113 182 1 1
NOD2 RASAL3 0 0 0 222 1 1
NOD2 NLRP5 0 0 323 168 1 1
NOD2 TMEM59 0 0 231 294 1 1
NOD2 MS4A7 0 0 0 151 1 1
NOD2 IL17A 0 0 615 615 1 2
NOD2 OLFM4 270 0 246 485 1 1
NOD2 EGF 0 0 194 194 1 2
NOD2 PRTN3 0 0 260 260 1 1
NOD2 TRIM5 0 0 213 222 1 1
NOD2 CX3CR1 0 0 326 379 1 1
NOD2 CRHR1 0 0 0 175 1 1
NOD2 EAF2 0 0 0 168 1 1
NOD2 PYDC1 0 0 165 258 1 1
NOD2 IL12RB2 0 0 244 243 1 1
NOD2 ST6GALNAC5 0 0 0 185 1 1
NOD2 LTF 0 0 112 161 1 1
NOD2 RPLP1 0 0 0 153 1 1
NOD2 HSPA4 0 0 181 181 1 1
NOD2 IRF2 0 0 181 286 1 1
NOD2 DEFB103B 0 0 404 404 1 1
NOD2 LRMP 0 0 0 170 1 1
NOD2 CXCL9 0 0 295 365 1 1
NOD2 IL12B 0 0 193 193 1 1
NOD2 CLEC12A 0 0 164 368 1 1
NOD2 HSP90B1 0 0 151 226 1 1
NOD2 CCR2 0 0 334 454 1 2
NOD2 DDX1 0 0 150 173 1 1
NOD2 DLG5 0 0 681 687 1 1
NOD2 IFIH1 0 0 636 692 1 1
NOD2 DIABLO 0 0 258 258 1 2
NOD2 SPATA2 129 0 228 298 1 1
NOD2 HSPA6 0 0 66 178 1 1
NOD2 TUFM 0 0 209 224 1 2
NOD2 GSDMB 0 0 181 181 1 1
NOD2 ARHGDIB 0 0 0 154 1 1
NOD2 LPO 0 0 87 253 1 1
NOD2 DNASE2 0 0 123 160 1 1
NOD2 MX2 0 0 129 199 1 1
NOD2 IL2RG 0 0 95 244 1 1
NOD2 PRF1 0 0 235 323 1 1
NOD2 CISH 0 0 235 297 1 1
NOD2 CD244 0 0 60 288 1 1
NOD2 PTGER4 0 0 345 409 1 1
NOD2 EAF1 0 0 95 269 1 1
NOD2 CRHR2 0 0 0 193 1 1
NOD2 CCR1 0 0 260 448 1 1
NOD2 P2RX7 0 0 284 355 1 2
NOD2 TRAPPC11 0 0 0 189 1 1
NOD2 FLG 0 0 150 168 1 1
NOD2 ARG1 0 0 216 244 1 2
NOD2 MAPK8 0 0 294 294 1 2
NOD2 FZD7 0 0 0 157 1 1
NOD2 VIM 675 0 345 778 1 2
NOD2 GCLC 0 0 0 164 1 1
NOD2 ADIPOQ 0 0 134 152 1 2
NOD2 MAP2K4 0 900 123 908 1 1
NOD2 LILRB2 0 0 67 562 1 1
NOD2 SLA 0 0 0 173 1 1
NOD2 HLA-DQA1 0 0 340 364 1 1
NOD2 CD79B 0 0 0 159 1 1
NOD2 ALOX12 0 0 63 153 1 1
NOD2 DMBT1 0 0 324 323 1 1
NOD2 TFEC 0 0 52 222 1 1
NOD2 CLEC4A 0 0 163 342 1 1
NOD2 SMAD4 0 0 113 171 1 2
NOD2 ACTA1 0 0 181 198 1 1
NOD2 UBD 0 0 137 154 1 1
NOD2 MUC12 0 0 291 290 1 1
NOD2 IL1RL2 0 0 248 248 1 1
NOD2 TAX1BP1 0 0 233 232 1 2
NOD2 ZNRF4 0 0 167 167 1 1
NOD2 NELFCD 0 0 234 234 1 1
NOD2 LY75 0 0 182 263 1 1
NOD2 MPEG1 0 0 90 331 1 1
NOD2 CASP10 0 0 108 164 1 1
NOD2 TNFRSF13B 0 0 141 158 1 1
NOD2 IL17RC 0 0 193 193 1 1
NOD2 UNC13D 0 0 123 190 1 1
NOD2 NLRP10 0 0 501 234 1 1
NOD2 LILRB1 0 0 60 157 1 1
NOD2 CLEC1B 0 0 66 163 1 1
NOD2 RB1CC1 0 0 212 280 1 2
NOD2 BACH2 0 0 161 161 1 1
NOD2 TLR1 0 0 681 791 1 1
NOD2 ENSG00000249141 0 0 213 221 1 1
NOD2 FZD2 0 0 0 157 1 1
NOD2 CARD10 0 0 233 249 1 1
NOD2 MAP3K8 0 0 203 270 1 1
NOD2 OSM 0 0 123 342 1 1
NOD2 DHX58 0 0 469 557 1 1
NOD2 IKZF3 0 0 137 160 1 1
NOD2 OASL 0 0 154 226 1 1
NOD2 RBCK1 675 0 390 798 1 1
NOD2 BRD9 0 0 0 157 1 1
NOD2 NLRP12 0 0 796 376 1 1
NOD2 CCL21 0 0 160 159 1 1
NOD2 BRCA1 0 0 134 152 1 2
NOD2 CD80 0 0 391 474 1 2
NOD2 IFNA1 0 0 504 504 1 1
NOD2 PARK2 270 0 294 462 1 1
NOD2 IL18 0 0 683 689 1 2
NOD2 IL15 0 0 324 340 1 1
NOD2 IRGM 270 0 955 965 1 2
NOD2 MYC 0 0 216 216 1 2
NOD2 ITGAE 0 0 392 400 1 1
NOD2 RNF125 0 0 204 204 1 1
NOD2 IL1R1 0 0 545 545 1 1
NOD2 FCGR1B 0 0 48 188 1 1
NOD2 CLECL1 0 0 0 153 1 1
NOD2 PI3 0 0 171 210 1 2
NOD2 ADAM10 0 0 113 171 1 1
NOD2 TAGAP 0 0 233 475 1 1
NOD2 TREM1 0 0 373 575 1 1
NOD2 LILRA1 0 0 0 338 1 1
NOD2 KIF21B 0 0 150 191 1 1
NOD2 TNFRSF6B 0 0 207 207 1 1
NOD2 AZI2 0 0 141 159 1 1
NOD2 SLAMF7 0 0 81 195 1 1
NOD2 GPSM3 0 0 55 173 1 1
NOD2 TRIM33 0 0 57 208 1 1
NOD2 IL36G 0 0 143 196 1 1
NOD2 TAB2 0 600 415 758 1 2
NOD2 DHX33 0 0 430 430 1 1
NOD2 CD300A 0 0 74 355 1 1
NOD2 TRAF2 0 0 255 283 1 2
NOD2 SLC15A4 270 0 421 559 1 1
NOD2 TAB1 0 600 375 745 1 1
NOD2 MX1 0 0 234 296 1 1
NOD2 DENND1C 0 0 0 213 1 1
NOD2 MEFV 0 0 768 782 1 1
NOD2 ACP5 0 0 69 179 1 1
NOD2 IL2RA 0 0 261 305 1 1
NOD2 PLCB2 0 0 0 214 1 1
NOD2 CECR1 0 0 143 185 1 1
NOD2 HLA-DQB1 0 0 143 244 1 1
NOD2 FCER2 0 0 0 213 1 1
NOD2 TPMT 0 0 201 201 1 1
NOD2 PTX3 0 0 107 201 1 1
NOD2 REG3G 0 0 346 386 1 1
NOD2 APAF1 0 0 391 566 1 2
NOD2 JAK2 0 0 359 382 1 2
NOD2 PLEKHA8 0 0 0 239 1 1
NOD2 NLRC5 0 0 637 425 1 1
NOD2 BRD7 0 0 66 251 1 1
NOD2 HOOK3 0 0 45 411 1 1
NOD2 NKD1 0 0 61 440 1 1
NOD2 LY86 0 0 94 363 1 1
NOD2 FGR 0 0 60 359 1 1
NOD2 CYBA 0 0 150 194 1 1
NOD2 CD101 0 0 74 164 1 1
NOD2 MUC5AC 0 0 171 234 1 1
NOD2 CCL25 0 0 172 171 1 1
NOD2 LYPD6 0 0 605 606 1 1
NOD2 MVB12A 0 0 0 155 1 1
NOD2 SLC9A4 0 0 297 297 1 1
NOD2 GATA3 0 0 234 234 1 1
NOD2 MICA 0 0 217 217 1 1
NOD2 TRIM23 0 0 112 202 1 1
NOD2 ERN1 0 0 285 302 1 2
NOD2 IFNA2 0 0 134 175 1 1
NOD2 MST1 0 0 122 185 1 2
NOD2 TRIM8 192 0 457 558 1 1
NOD2 CD300C 0 0 235 468 1 1
NOD2 DEFA5 0 0 518 518 1 1
NOD2 PPP1R12C 312 0 0 311 1 1
NOD2 STAT3 0 0 470 481 1 2
NOD2 CDK14 0 0 0 212 1 1
NOD2 PTPN22 0 0 504 548 1 1
NOD2 MKKS 0 0 124 164 1 1
NOD2 EIF2AK4 0 0 125 183 1 2
NOD2 RAB2A 0 0 100 191 1 1
NOD2 CFTR 0 0 242 258 1 2
NOD2 IRF9 0 0 203 242 1 1
NOD2 LCN2 0 0 283 304 1 1
NOD2 TP53 0 0 219 219 1 2
NOD2 TOR1A 0 0 195 195 1 1
NOD2 DEFB103A 0 0 405 405 1 1
NOD2 FES 0 0 0 161 1 1
NOD2 MYD88 0 0 710 753 1 2
NOD2 ADORA3 0 0 107 150 1 1
NOD2 TNFRSF4 0 0 150 237 1 1
NOD2 EGFR 0 0 198 198 1 2
NOD2 CFLAR 0 0 235 291 1 2
NOD2 PSTPIP1 0 0 556 609 1 1
NOD2 ECM1 0 0 371 371 1 1
NOD2 LAMP1 0 0 202 213 1 2
NOD2 TSLP 0 0 391 390 1 1
NOD2 SARM1 0 0 234 234 1 1
NOD2 ESX1 0 0 394 436 1 1
NOD2 FADD 0 0 294 294 1 2
NOD2 DOK3 0 0 0 175 1 1
NOD2 CAMP 0 0 459 514 1 2
NOD2 TRAF1 0 0 306 413 1 1
NOD2 CARD9 0 600 986 994 1 1
NOD2 RBL1 189 0 0 189 1 1
NOD2 MUC5B 0 0 203 263 1 1
NOD2 LMNA 192 0 81 225 1 2
NOD2 GZMH 0 0 0 151 1 1
NOD2 IRAK1 0 600 632 852 1 1
NOD2 PSTPIP2 0 0 257 308 1 1
NOD2 CSF3 0 0 325 325 1 1
NOD2 NFKBIZ 0 0 232 277 1 1
NOD2 CD200R1 0 0 140 220 1 1
NOD2 CRADD 0 0 397 396 1 1
NOD2 LCP2 0 0 59 326 1 1
NOD2 ZBP1 0 0 230 290 1 1
NOD2 LIPN 0 0 0 258 1 1
NOD2 APBB1IP 0 0 0 151 1 1
NOD2 MAP3K7 675 600 488 927 1 2
NOD2 SELPLG 0 0 90 230 1 1
NOD2 LPP 0 0 112 162 1 1
NOD2 NLRP4 0 0 510 248 1 1
NOD2 SULT1A1 0 0 414 414 1 1
NOD2 CD40LG 0 0 323 353 1 1
NOD2 PTGS1 0 0 107 154 1 1
NOD2 RPL14 0 0 0 216 1 1
NOD2 DEFB128 0 0 113 307 1 1
NOD2 NOTCH1 0 0 171 196 1 2
NOD2 ENTPD1 0 0 95 202 1 1
NOD2 CXCR4 0 0 194 242 1 2
NOD2 TRAF4 270 0 938 954 1 1
NOD2 GIMAP8 0 0 0 214 1 1
NOD2 MTMR3 0 0 214 214 1 2
NOD2 SAA1 0 0 180 186 1 1
NOD2 CD163 0 0 175 261 1 1
NOD2 XPNPEP1 0 0 260 275 1 1
NOD2 DDX21 0 0 176 188 1 1
NOD2 GIMAP6 0 0 0 181 1 1
NOD2 POTEF 0 0 135 169 1 1
NOD2 RPL13A 192 0 71 217 1 1
NOD2 TRIM59 0 0 66 279 1 1
NOD2 MYO9B 0 0 235 272 1 1
NOD2 NLRP1 270 800 988 916 1 1
NOD2 MTOR 0 0 257 256 1 2
NOD2 SULT1A2 0 0 410 410 1 1
NOD2 SPINK5 0 0 167 167 1 1
NOD2 IL6 0 0 681 690 1 2
NOD2 LYZ 0 0 205 311 1 1
NOD2 MPO 0 0 358 396 1 2
NOD2 SUMO4 0 0 180 180 1 1
NOD2 NLRC3 0 0 654 355 1 1
NOD2 IL3RA 0 0 123 193 1 1
NOD2 PIK3C3 0 0 294 294 1 2
NOD2 BTLA 0 0 56 172 1 1
NOD2 DOK2 0 0 74 218 1 1
NOD2 PLEK 0 0 74 375 1 1
NOD2 OCLN 0 0 320 319 1 1
NOD2 SECTM1 0 0 0 175 1 1
NOD2 TNFRSF1A 0 0 519 519 1 1
NOD2 GZMB 0 0 182 280 1 1
NOD2 DEFB125 0 0 109 346 1 1
NOD2 DOCK7 312 0 67 338 1 1
NOD2 DEFB1 0 0 452 452 1 1
NOD2 RNASE1 0 0 0 156 1 1
NOD2 STAT1 0 0 438 448 1 2
NOD2 RAB5A 0 0 125 159 1 2
NOD2 IL1B 0 0 736 783 1 2
NOD2 NKX6-2 0 0 0 207 1 1
NOD2 HIF1A 0 0 170 169 1 2
NOD2 CYP27B1 0 0 234 240 1 1
NOD2 OAS1 0 0 160 227 1 1
NOD2 TRIM27 270 0 346 548 1 1
NOD2 TRAF5 0 0 341 360 1 1
NOD2 HCLS1 0 0 0 229 1 1
NOD2 PRKCB 0 0 81 209 1 2
NOD2 OTUD3 0 0 137 190 1 1
NOD2 IL6R 0 0 213 263 1 1
NOD2 NCR1 0 0 161 179 1 1
NOD2 MAPK13 0 650 123 684 1 1
NOD2 KCNQ1 0 0 0 181 1 1
NOD2 CXCL8 0 0 653 681 1 2
NOD2 ENSG00000268500 0 0 0 332 1 1
NOD2 RNF11 0 0 112 178 1 1
NOD2 FCRL3 0 0 125 156 1 1
NOD2 LURAP1L 192 0 0 207 1 1
NOD2 GIMAP5 0 0 0 163 1 1
NOD2 CTNNB1 0 0 244 243 1 2
NOD2 HRAS 0 0 136 159 1 2
NOD2 FCGR3A 0 0 252 386 1 1
NOD2 MAP1LC3A 0 0 162 180 1 2
NOD2 MS4A4A 0 0 0 175 1 1
NOD2 B7RP1 0 0 242 241 1 1
NOD2 ERAP1 0 0 294 309 1 1
NOD2 IKBKE 0 0 181 302 1 1
NOD2 MVB12B 0 0 0 155 1 1
NOD2 SAMSN1 0 0 0 196 1 1
NOD2 TNFRSF1B 0 0 243 330 1 1
NOD2 F5 0 0 62 160 1 1
NOD2 ERBB2IP 298 800 983 997 1 1
NOD2 LACC1 0 0 603 603 1 1
NOD2 MYOM2 0 0 160 159 1 1
NOD2 C3AR1 0 0 91 241 1 1
NOD2 CXCR2 0 0 282 326 1 1
NOD2 ARHGAP4 0 0 0 175 1 1
NOD2 TAB3 0 600 334 722 1 1
NOD2 STAT4 0 0 321 359 1 1
NOD2 DPEP2 0 0 64 213 1 1
NOD2 TLR10 0 0 467 532 1 1
NOD2 CLEC7A 0 0 651 696 1 1
NOD2 ZAP70 0 0 134 185 1 1
NOD2 P4HA2 0 0 396 396 1 1
NOD2 RAN 0 0 0 242 1 2
NOD2 PIK3R4 0 0 180 209 1 2
NOD2 TRIM25 0 0 294 330 1 1
NOD2 P2RY8 0 0 0 176 1 1
NOD2 PRR16 192 0 0 192 1 1
NOD2 CCL4L1 0 0 193 211 1 1
NOD2 AOC3 0 0 145 165 1 1
NOD2 ENSG00000026036 0 0 207 207 1 1
NOD2 RELA 270 0 370 520 1 2
NOD2 BCL2L1 0 0 193 193 1 2
NOD2 ASGR2 0 0 108 161 1 1
NOD2 NFKB1 0 0 365 393 1 2
NOD2 GAPDH 0 0 395 410 1 2
NOD2 ATG14 0 0 267 267 1 2
NOD2 TNFRSF25 0 0 241 247 1 1
NOD2 SH2B3 0 0 412 412 1 1
NOD2 APTX 0 0 0 203 1 1
NOD2 MUC3A 0 0 275 275 1 1
NOD2 TLR4 0 0 922 927 1 2
NOD2 NOS2 0 0 260 263 1 2
NOD2 CX3CL1 0 0 180 209 1 1
NOD2 CD1A 0 0 112 161 1 1
NOD2 MAP2K7 0 900 113 907 1 1
NOD2 GAPT 0 0 0 181 1 1
NOD2 SCYL1 192 0 0 192 1 1
NOD2 TNFSF15 0 0 678 678 1 1
NOD2 ALPI 192 0 0 197 1 1
NOD2 GABARAPL2 0 0 272 287 1 2
NOD2 CD14 0 0 113 349 1 1
NOD2 CD83 0 0 233 270 1 1
NOD2 PGLYRP2 0 0 395 445 1 1
NOD2 GGCT 0 0 74 259 1 1
NOD2 C1orf106 0 0 413 412 1 1
NOD2 HAMP 0 0 150 173 1 1
NOD2 OAS2 0 0 977 980 1 1
NOD2 HLA-DPB1 0 0 112 245 1 1
NOD2 LRSAM1 0 0 181 182 1 2
NOD2 TNP1 0 0 245 244 1 1
NOD2 SLC22A4 0 0 619 628 1 1
NOD2 KCNJ11 0 0 400 400 1 1
NOD2 ARHGAP30 0 0 0 282 1 1
NOD2 KLHDC7B 0 0 0 175 1 1
NOD2 HCAR2 0 0 211 389 1 1
NOD2 TTC7A 0 0 310 330 1 1
NOD2 CCL13 192 0 89 261 1 1
NOD2 GSDMD 0 0 287 312 1 2
NOD2 MUC17 0 0 291 290 1 1
NOD2 CREB1 0 0 155 161 1 2
NOD2 HCST 0 0 57 226 1 1
NOD2 PLCG2 0 0 207 259 1 1
NOD2 HAL 0 0 0 165 1 1
NOD2 CCL5 0 0 458 508 1 2
NOD2 DHX9 0 0 146 224 1 1
NOD2 HLA-DQA2 0 0 232 268 1 1
NOD2 BIRC2 270 900 578 966 1 1
NOD2 IFNG 0 0 422 596 1 2
NOD2 GZMM 0 0 214 252 1 1
NOD2 IL2RB 0 0 100 214 1 1
NOD2 HSPD1 0 0 181 203 1 1
NOD2 LGALS9 0 0 87 246 1 1
NOD2 TNFSF13 0 0 0 151 1 1
NOD2 ANXA5 0 0 167 167 1 2
NOD2 CXCL13 0 0 211 229 1 1
NOD2 C5AR1 0 0 190 267 1 1
NOD2 IL4R 0 0 236 301 1 1
NOD2 MAPKBP1 0 0 224 224 1 1
NOD2 ODF3B 0 0 0 214 1 1
NOD2 GSDMA 0 0 144 150 1 1
NOD2 CLEC4D 0 0 321 443 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0043531 Molecular Function ADP binding enables ISS
GO:0005524 Molecular Function ATP binding enables IEA
GO:0050700 Molecular Function CARD domain binding enables IPI
GO:0030544 Molecular Function Hsp70 protein binding enables IPI
GO:0051879 Molecular Function Hsp90 protein binding enables IDA
GO:0003779 Molecular Function actin binding enables IDA
GO:0019899 Molecular Function enzyme binding enables IPI
GO:0032500 Molecular Function muramyl dipeptide binding enables IDA
GO:0038187 Molecular Function pattern recognition receptor activity enables IDA
GO:0042834 Molecular Function peptidoglycan binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0019901 Molecular Function protein kinase binding enables IPI
GO:0044877 Molecular Function protein-containing complex binding enables IPI
GO:0043130 Molecular Function ubiquitin binding enables IDA
GO:0070371 Biological Process ERK1 and ERK2 cascade involved_in IEA
GO:0007254 Biological Process JNK cascade involved_in IEA
GO:0002250 Biological Process adaptive immune response involved_in IEA
GO:0002815 Biological Process biosynthetic process of antibacterial peptides active against Gram-positive bacteria involved_in IEA
GO:0007249 Biological Process canonical NF-kappaB signal transduction involved_in IEA
GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IMP
GO:0071225 Biological Process cellular response to muramyl dipeptide involved_in IDA
GO:0071225 Biological Process cellular response to muramyl dipeptide involved_in IMP
GO:0071407 Biological Process cellular response to organic cyclic compound involved_in IEA
GO:0071224 Biological Process cellular response to peptidoglycan involved_in IEA
GO:0006952 Biological Process defense response involved_in TAS
GO:0042742 Biological Process defense response to bacterium involved_in IBA
GO:0042742 Biological Process defense response to bacterium involved_in IDA
GO:0016045 Biological Process detection of bacterium involved_in IDA
GO:0009595 Biological Process detection of biotic stimulus involved_in TAS
GO:0032498 Biological Process detection of muramyl dipeptide acts_upstream_of_or_within IDA
GO:0032498 Biological Process detection of muramyl dipeptide involved_in IDA
GO:0051649 Biological Process establishment of localization in cell involved_in IEA
GO:0048874 Biological Process host-mediated regulation of intestinal microbiota composition involved_in ISS
GO:0045087 Biological Process innate immune response involved_in IDA
GO:0045087 Biological Process innate immune response involved_in NAS
GO:0002227 Biological Process innate immune response in mucosa involved_in IEA
GO:0036335 Biological Process intestinal stem cell homeostasis involved_in ISS
GO:0035556 Biological Process intracellular signal transduction involved_in IBA
GO:0035556 Biological Process intracellular signal transduction involved_in IDA
GO:0030277 Biological Process maintenance of gastrointestinal epithelium involved_in IMP
GO:0002710 Biological Process negative regulation of T cell mediated immunity involved_in IEA
GO:0002862 Biological Process negative regulation of inflammatory response to antigenic stimulus involved_in IEA
GO:0032695 Biological Process negative regulation of interleukin-12 production involved_in IEA
GO:0032701 Biological Process negative regulation of interleukin-18 production involved_in IEA
GO:0032703 Biological Process negative regulation of interleukin-2 production involved_in IEA
GO:2000110 Biological Process negative regulation of macrophage apoptotic process involved_in ISS
GO:0010936 Biological Process negative regulation of macrophage cytokine production involved_in IEA
GO:0034136 Biological Process negative regulation of toll-like receptor 2 signaling pathway involved_in IEA
GO:0032720 Biological Process negative regulation of tumor necrosis factor production involved_in IEA
GO:0032689 Biological Process negative regulation of type II interferon production involved_in IEA
GO:0038061 Biological Process non-canonical NF-kappaB signal transduction involved_in IEA
GO:0070431 Biological Process nucleotide-binding oligomerization domain containing 2 signaling pathway acts_upstream_of_or_within IDA
GO:0070431 Biological Process nucleotide-binding oligomerization domain containing 2 signaling pathway involved_in IDA
GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in IDA
GO:0006909 Biological Process phagocytosis involved_in IEA
GO:0050871 Biological Process positive regulation of B cell activation involved_in IDA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in ISS
GO:0046330 Biological Process positive regulation of JNK cascade acts_upstream_of_or_within IDA
GO:0043410 Biological Process positive regulation of MAPK cascade involved_in ISS
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity acts_upstream_of_or_within IDA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IMP
GO:0045747 Biological Process positive regulation of Notch signaling pathway involved_in ISS
GO:0006965 Biological Process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria involved_in IEA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction acts_upstream_of_or_within IDA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IMP
GO:0002720 Biological Process positive regulation of cytokine production involved in immune response involved_in IMP
GO:1900017 Biological Process positive regulation of cytokine production involved in inflammatory response involved_in IDA
GO:0002606 Biological Process positive regulation of dendritic cell antigen processing and presentation involved_in ISS
GO:0002732 Biological Process positive regulation of dendritic cell cytokine production involved_in IEA
GO:0050679 Biological Process positive regulation of epithelial cell proliferation involved_in ISS
GO:0046645 Biological Process positive regulation of gamma-delta T cell activation involved_in ISS
GO:0002925 Biological Process positive regulation of humoral immune response mediated by circulating immunoglobulin involved_in IEA
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IDA
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IMP
GO:0032733 Biological Process positive regulation of interleukin-10 production acts_upstream_of ISS
GO:0032735 Biological Process positive regulation of interleukin-12 production involved_in IEA
GO:0032740 Biological Process positive regulation of interleukin-17 production involved_in IMP
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in IDA
GO:0032757 Biological Process positive regulation of interleukin-8 production involved_in IMP
GO:0060907 Biological Process positive regulation of macrophage cytokine production involved_in IEA
GO:1901526 Biological Process positive regulation of mitophagy involved_in ISS
GO:0071639 Biological Process positive regulation of monocyte chemotactic protein-1 production involved_in IEA
GO:0051770 Biological Process positive regulation of nitric-oxide synthase biosynthetic process involved_in ISS
GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IMP
GO:0050731 Biological Process positive regulation of peptidyl-tyrosine phosphorylation involved_in IEA
GO:0050766 Biological Process positive regulation of phagocytosis involved_in IEA
GO:1902523 Biological Process positive regulation of protein K63-linked ubiquitination involved_in IMP
GO:0032874 Biological Process positive regulation of stress-activated MAPK cascade acts_upstream_of_or_within IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0032760 Biological Process positive regulation of tumor necrosis factor production acts_upstream_of_or_within IDA
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IMP
GO:0002830 Biological Process positive regulation of type 2 immune response involved_in IMP
GO:1904417 Biological Process positive regulation of xenophagy involved_in IEA
GO:0032098 Biological Process regulation of appetite involved_in ISS
GO:0050727 Biological Process regulation of inflammatory response involved_in IC
GO:0090022 Biological Process regulation of neutrophil chemotaxis involved_in IEA
GO:0034976 Biological Process response to endoplasmic reticulum stress involved_in IEA
GO:0043330 Biological Process response to exogenous dsRNA involved_in IEA
GO:0032495 Biological Process response to muramyl dipeptide involved_in IBA
GO:0032495 Biological Process response to muramyl dipeptide involved_in IDA
GO:0032495 Biological Process response to muramyl dipeptide involved_in IMP
GO:0007584 Biological Process response to nutrient involved_in IEA
GO:0001659 Biological Process temperature homeostasis involved_in ISS
GO:0034134 Biological Process toll-like receptor 2 signaling pathway involved_in IEA
GO:0098792 Biological Process xenophagy involved_in IEA
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0016323 Cellular Component basolateral plasma membrane located_in IDA
GO:0009986 Cellular Component cell surface located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005737 Cellular Component cytoplasm located_in TAS
GO:0005856 Cellular Component cytoskeleton located_in IDA
GO:0005829 Cellular Component cytosol is_active_in IBA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0019897 Cellular Component extrinsic component of plasma membrane is_active_in IDA
GO:0005739 Cellular Component mitochondrion located_in IEA
GO:0045335 Cellular Component phagocytic vesicle located_in IDA
GO:0005886 Cellular Component plasma membrane is_active_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IMP
GO:0032991 Cellular Component protein-containing complex part_of IDA
GO:0031982 Cellular Component vesicle located_in IDA
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Reactome R-HSA-166058
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade Reactome R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade Reactome R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade Reactome R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade Reactome R-HSA-168188
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
NOD1/2 Signaling Pathway Reactome R-HSA-168638
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
Toll-like Receptor Cascades Reactome R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade Reactome R-HSA-181438
Metabolism of proteins Reactome R-HSA-392499
TAK1-dependent IKK and NF-kappa-B activation Reactome R-HSA-445989
Interleukin-1 family signaling Reactome R-HSA-446652
Interleukin-17 signaling Reactome R-HSA-448424
Signaling by Interleukins Reactome R-HSA-449147
MAP kinase activation Reactome R-HSA-450294
activated TAK1 mediates p38 MAPK activation Reactome R-HSA-450302
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Reactome R-HSA-450321
Infectious disease Reactome R-HSA-5663205
Deubiquitination Reactome R-HSA-5688426
Ovarian tumor domain proteases Reactome R-HSA-5689896
Post-translational protein modification Reactome R-HSA-597592
Interleukin-1 signaling Reactome R-HSA-9020702
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-2 Infection Reactome R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
SARS-CoV-2-host interactions Reactome R-HSA-9705683
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
MyD88 cascade initiated on plasma membrane Reactome R-HSA-975871
Viral Infection Pathways Reactome R-HSA-9824446
Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
Inflammatory bowel disease signaling (WP5198) WikiPathways WP5198_r123858
Burn wound healing (WP5055) WikiPathways WP5055_r122621
Acute viral myocarditis (WP4298) WikiPathways WP4298_r123508
Ulcerative colitis signaling (WP5174) WikiPathways WP5174_r121476
Non-genomic actions of 1,25 dihydroxyvitamin D3 (WP4341) WikiPathways WP4341_r122900
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_163434 1 miscRNA transcript variant 4 NC_000016 Reference
XR_007064895 1 miscRNA transcript variant X11 NC_000016 Reference
XR_007064894 1 miscRNA transcript variant X8 NC_000016 Reference
NM_001370466 1 mRNA transcript variant 3 NC_000016 Reference
XM_006721242 5 mRNA transcript variant X1 NC_000016 Reference
XM_047434453 1 mRNA transcript variant X3 NC_000016 Reference
XM_017023536 2 mRNA transcript variant X5 NC_000016 Reference
XM_017023537 2 mRNA transcript variant X6 NC_000016 Reference
XM_047434457 1 mRNA transcript variant X14 NC_000016 Reference
XM_047434456 1 mRNA transcript variant X13 NC_000016 Reference
XM_047434455 1 mRNA transcript variant X12 NC_000016 Reference
XM_011523260 4 mRNA transcript variant X10 NC_000016 Reference
XM_006721243 5 mRNA transcript variant X9 NC_000016 Reference
XM_011523261 3 mRNA transcript variant X7 NC_000016 Reference
NM_022162 3 mRNA transcript variant 1 NC_000016 Reference
NM_001293557 2 mRNA transcript variant 2 NC_000016 Reference
XM_047434452 1 mRNA transcript variant X2 NC_000016 Reference
XM_047434454 1 mRNA transcript variant X4 NC_000016 Reference